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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
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                <person name="Feng X."/>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461186">
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    <feature type="non-terminal residue" evidence="1">
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07381.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="7479" checksum="994DE9613189E7CC" modified="2015-12-09" version="1" fragment="single">FVYTGEVERLLREYRQNQELVRNIGAHYYQIIYPVQLRHHEKMGISTREVNTQKGASVSQGLSS</sequence>
</entry>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
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                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
    <sequence length="217" mass="23553" checksum="30EAB7039446237C" modified="2015-12-09" version="1">MKVTSNPIILMGGPFKGDPLKGLSVCPIAFRPVAKTEIPCLKFPPPPLNSRRKCSNEICRVTCMNGYTFPDGSTVSEIRCMAGAWEPTIPNCIPECNLPCFNGGVCGAPNTCLCPTAYKGSQCQYSNCDQECQNGGICVAKNFCQCRDNFYGNYCEIKNECLAPPNLPMNSRRLCSTLSCIVTCKNGYKFPDGSTDAGVHCVEGAWQPTSIPYCILN</sequence>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">RR48_04196</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBK5"/>
    <dbReference type="InParanoid" id="A0A0N0PBK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="7399" checksum="E6578DB346DB51CE" modified="2015-12-09" version="1">MQRLENEVGSEVTPRLGYHGKTKYKYAFHEPWNPLDRLTLLAQAEKDENPELQQSADANNNQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCU3</accession>
    <name>A0A0N0PCU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 568</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCU3"/>
    <dbReference type="InParanoid" id="A0A0N0PCU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="271" mass="30723" checksum="AC5BF70A440E08A5" modified="2015-12-09" version="1">MDKCAICLKPAVQLFETGKDGVYACFKCQPLVPEVTIGDHPSEATEPKSSKTIEVSIDPDGLYCDICEKSFQKSTQLQSHMRNHRAERRFVCTYCNKAFSQSNNLRAHLRIHTNERPYKCSECGKAFTQVTNLNNHVRLHTGERPYVCPEEGCGKAYAQVTNLNQHRKRHLSGPPPKSAYDCPVCGESFQQRNHMHTHRARRAASANTSPTHPDEGPPKGSKLVCADTGYIYVIVSRDIYDPEENSMYDEVKITKQERQYSPKLKVQSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDK7</accession>
    <name>A0A0N0PDK7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_01988</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDK7"/>
    <dbReference type="FunCoup" id="A0A0N0PDK7">
        <property type="interactions" value="1307"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDK7"/>
    <dbReference type="InParanoid" id="A0A0N0PDK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ17500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="605" mass="66280" checksum="204A9F85DDDE54FF" modified="2015-12-09" version="1">MGDSSSTPSLSPTEAEPSSPNLFEAESPPRAPRRARRARRLAGSPGTPPGAPPDALALGPASEDSLVSTNYDTEVTRPDLPPTIAPYDLATLDDNSDSVRPQSSRSDHVTPNLTTEESNSLMSLPDSKQDDLEEPPAKVRKLSSPKLNDDTDGETCPICLDTWGNSGEHRLVALKCGHLFGAQCVERWLKAQPSRERTCPTCKSKAALKDIRFIYAKRLVAADSSQITALQKQVDSLQTEKSRVELELQNCKIAHRACIMQLEVLRSSLMKPQVAKEQPVRKTWRFALEKNLEISKDGGCRVMTYNCRTYELYVSQKSVNYLFPGYGIRKVSCVDNKAGQFVHLHPKPIRDLTYSQPRDLLLSAGLDGAARVVERGVPGLAVHCGLPLWSCSWDHLRTNEFYVGGVGGVVHQYDVRNPAHYIQRLTAPGDMSPVVSLRSTEYGLLSCQLNSCWLWVANMRQWEPRALPLEGPFMSLSYDEESHRALVSCRPGGTERARLALCRLRASAPGGEVALEPEQSFPGSGRATLMSRAAWVRAPGALWAAAHSEGEAALRLHGLEGARSVSLPAAEPALDVCALQLNGDTVLAALSEWRLRLYKAITTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEJ4</accession>
    <name>A0A0N0PEJ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEJ4"/>
    <dbReference type="InParanoid" id="A0A0N0PEJ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857520" evidence="1">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="152" mass="17422" checksum="2B1806348CD40B5F" modified="2015-12-09" version="1">MKANKLVIQAFAVILLLQLVDSKSTFDIPNLRSDPLKELSEDIKWLIPVRVKRSAIVYNRCPIGYKRLPPPITCMRCDFCPLSSEVVENGVWLALPGVRIKPNRVSDLSTQISDQTGWSARLIGTKREQESHVDRIPNRLYYKLKTDRLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEN5</accession>
    <name>A0A0N0PEN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEN5"/>
    <dbReference type="InParanoid" id="A0A0N0PEN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="419" mass="48294" checksum="FF1559D5B98646CB" modified="2015-12-09" version="1">MTYTLCQVCLKGRDNVFPLSGKDIEAYNQICKENTLTVQNNINNISLSSTRTYYIGPDFMHLDTNIKAEDNKIVYITEDEDDVPLVLFCESSMDAAEFENGTVSDNDTNMLEEKSNTELNLKNDPAKNGIKVKKQKKVLKEGFSSRMVQETSEYTVIKLTKEQVLEEMKERAKSEKYLRAPYKCESCVKGFNFEDVLQSHMEKHLQKQGQYRCELCSQYCPSSVSLRGHMKSHTTRYRCKICGYIRLSRQHVLEHHTIVHTHAAAAYSCGRCVFTTNKRTVMQRHVRVHNSTAAHECHKCGKMYKSLESLRVHTMRHDNKKKFQCDQCNLSFVYPTQLHKHVQSVHIRRDYYCVECDIKFKSMFLTSDAHQGSLVADLDRAMCLTTALTAENLLEFVKLEVRLSGLPSNSFRLTANQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6C9</accession>
    <name>A0A0N1I6C9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6C9"/>
    <dbReference type="FunCoup" id="A0A0N1I6C9">
        <property type="interactions" value="1192"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I6C9"/>
    <dbReference type="KEGG" id="pmac:106719313"/>
    <dbReference type="InParanoid" id="A0A0N1I6C9"/>
    <dbReference type="OMA" id="IPGCADS"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21430" checksum="F3AAAA3FD534B8FA" modified="2015-12-09" version="1">MATTGYEHDADGCKFIPASQRPDGTWRKPRRIREGYVPQEEVPLYESKGKQFKARQNTGLPVGLTPEIVAQAQKKKGQGGTIQPIPGMIINVEKKKKKKKSGVEEAADKLSKCEIIEPKFSTPTPSSNNSTPSSDPAKRLKNLRKKLREIEMLEEKIKSGMLKTPDKDQKEKLSKKNDIVMEIEKLEIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6M4</accession>
    <name>A0A0N1I6M4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Larval/pupal rigid cuticle protein 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6M4"/>
    <dbReference type="STRING" id="76193.A0A0N1I6M4"/>
    <dbReference type="InParanoid" id="A0A0N1I6M4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873773" evidence="4">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="14409" checksum="885CD9D6AC5BDCF9" modified="2015-12-09" version="1">MLNRCPPVMSIVFLFALVAVCAADYSQFSYGVADPYTGDYKSQIESRAGDRVRGQYSLLDADGTRRTVDYAAGAEGFNANVRKDPALIPAASLAYAAPAYPYGYGYPYGYNNAAFGYGAYGYAAPYAFRRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I724</accession>
    <name>A0A0N1I724_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FLYWCH-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I724"/>
    <dbReference type="STRING" id="76193.A0A0N1I724"/>
    <dbReference type="InParanoid" id="A0A0N1I724"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="189" mass="21641" checksum="CF874F657645C866" modified="2015-12-09" version="1">MTNGMPKLRWRCSTHCDRGCFAAVYTINNVLVSVKSEHNHPPAAPRNVQITFSKNRKGGLLLELNGYTYRRHTNRLTNGMPKLRWRCSTHCHRGCIAAVYTINNALVSVKSEHNHLPAVRRKILEFIQSKRGKRLLLYEGYSYYATSGGPTIRWRCSTNSYCGCRATVHTYDDVILYTRGHHGHPPRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8G4</accession>
    <name>A0A0N1I8G4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460773">
        <property type="protein sequence ID" value="KPJ12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8G4"/>
    <dbReference type="FunCoup" id="A0A0N1I8G4">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8G4"/>
    <dbReference type="KEGG" id="pmac:106713654"/>
    <dbReference type="InParanoid" id="A0A0N1I8G4"/>
    <dbReference type="OrthoDB" id="25157at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="566" mass="64418" checksum="7D95FF2996A6B19B" modified="2015-12-09" version="1">MASKDREEPAMLAYESFLKKDYVSAFQHLNELEGLVTNTNLIKRVQQNQAVVEFYGSDLKDIEKFKCTMSLLIGLTFPDVEMKELNLPFTLYNYAVLLYHSRHYYQCTVVLEKLLMTKNIKDVKLYQQIVLLLMEATLCRRTYDKTLEVAKTYGEPIKSNNEIVPLFERLISRAQVFVGQKIKLKPDCIENVFIIAQQQYLNGDLKESANTLGLYKSLKFNYDVKTQGEDIWAAINNNLGVIYLSIKKPFLAAKYFQHAVKEHFKAMESEDRERLIDCKDRPIYVYNLGLALLAANNAEGAFECLVEAARHYPNNPRIWLRLAECCVKKCCNEEAQQFTVKKLGSGPHTRILLAKEKPEKYSTSGESFAIPSLSLEFAALCLKNAISLLPNQEAPSDITAPLFQAPPGPPINWKQCCELKNSILVLQSYVYLNLQDPQSASITANELLSQPDVSNSHKAWAHIYAAEALINLDKITEAVEHLHPPMIHELVSVLPYQMRDLIAVSVWAKAAVCHILRGDLVTARKILLQINSPRVLPLQMYLEICTGNIENCHNILRKLRFNNLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBZ5</accession>
    <name>A0A0N1IBZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Extracellular domains-containing protein CG31004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IBZ5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBZ5"/>
    <dbReference type="InParanoid" id="A0A0N1IBZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873838" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="12">
        <location>
            <begin position="254"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="641"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="805"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1330"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1524"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1330"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1524"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1562"/>
            <end position="1582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1590" mass="181746" checksum="16555140942E772D" modified="2015-12-09" version="1">MGVKIKIALVLLVALSVSGQDLVVNEENETISDVDTKLDEAIENVEVSVDKETAPVEVISDTNDLQVRNGKYQMLDDTVEGAVSDLTDIAIDTNNGQNERQILMPSTTAPTNNDFAHIDGRVLPSTTYQNNGQPYVITPQRLAQVRSNFMYWFYDQGGNENIGDYQRDIHTSTPQIHKNFNFQLPFFGFRFNYTRLSMNGYIYFSDPPDHYTYPLSFPVRDWPAVNDPSFIGIFFSKCRIGSQRPEDPDQRRPGVYFRMDRDLQTRTDQLGVEMRERITWDIREGVIGSDTFFPKHAITMTWKNMSFAGGIDNSLFVTNTFQMVLATDEVFTYAIFNYLEINWSSHTEAGGDTTTGEGGVPAYIGFNAGNGTQSYEYKPYSQASVLRDLTGRGWANGFPGRHIFRIDEKILMGTCNKDIDGANLPLMFAPESGNMLGGTIVNITGPCFNPNDRITCRFDTESVVGAVVDVNRAICVQPRFWHNGYARFEIAINNEPYKWKGKFFVETPATAAEKIFFPDNAIHERSPREIRITWDRFNLTSNLNVQLQISLWGYKEITIRPQLEYIDMIEVGVANTGEYIINPENFRNRENIMHNDMQFGFIQINLTTPEVFKGVPISPILWSRPIPLGWYFDKQWERLHGQRWPMSMCNNWLRTDRFLKNFASQIWICPCTLEHALLDKGRFMPDLGCDKDTNPTCRYHWGGVHCVRSGAPSAEGSGQQCCYDKNGFLMLSYDQMWGSRPHRSHDFGFTPYNEANKVPSLSHWFHDMIPFYQCCMWQEEQAVGCETFRFERRPSQDCVAYQSPGVAGIFGDPHIIKFDDLQYTFNGKGEYVLVRVDHPHLKLDVQGRFEQVPKNIYGPVNATHLTSVVAASNNSVPIEVRLRPQHAQWRYRLDVFADNKRIYFDRPALRVQYFPGVTVYQPMYILNQSEIVIMFSSGAGIEVVENKGFMTARVYLPWNYMNQTRGLFGNWSLDLNDDFMRPDGTLATVDVNNFQSAHRDFAQHWQLTDREQRDIGVAMFVREYGRTAAYYNDNQFIPNFIREPADFLPTNRSHDVDRAIEICQDSYQCRYDYGMTLNRDMAEFTKNYQSSLTNIKEQNARRVISCGILETPRFGRKSNFFFTPGTRVNFECNQDFILIGDKRRVCEDNGRWNLPDYGYTECLRNQEYSQRALFLTWGIIVAVILPLGLLICLLWFWCCYKPRSEGKETFSFQNIPRSKSASRLNLRSSSMGNITDTMKSSTLPDTPTEEKQKANLVRSAPPPPTDGESSGLGYTDSNKSDSGKSDKSTLPKKRRAYDKTYRTNEPLPNAPDVEFPEKLWDLSEEDLLSITSPSDSESNRESTLTRPAKDIEYVSKPRQTGRNALPSDSGYSTKDGSEDPYAPKFEDQYSPIPSHYSPTYSEIYSPPISPTSDVSPRNTYNNPGLPEAPKSAPPTEIKTFTMPPQRGKSVETLIDPPAAEAPTFSSRQEYSARTLGATWGIISAVMVPIVILLICVGWRILKRRKEDDKDENDYLNVRTRAIDPDDSFKVNSDDDSIPYKKDTTEDTPEPTEAVKVADDNEQPTYPYGQPYQEQPQQSQPRQWTGETEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID80</accession>
    <name>A0A0N1ID80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460813">
        <property type="protein sequence ID" value="KPJ12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID80"/>
    <dbReference type="FunCoup" id="A0A0N1ID80">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ID80"/>
    <dbReference type="InParanoid" id="A0A0N1ID80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="964"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="964"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="660"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="706"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="748"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113302" checksum="2C5E1E04AE042DBD" modified="2015-12-09" version="1">MEVVGSEIGQKMRSAIKAKLTELGCYVDDELPDYVMVMVANKRTRAQMDEDLQLFLGDNTELFVNWLHQVLKKLQEVQVTTPLKVVETEKVKERSKSKERKPKEKKEKEKTKKSDGGKKAKKKEKEKTHKKKEDKKVHKEKKKSKRHELIRPNIPPLLMNMEKESEPSITDVFAGQILKNHGITLDHKQDVTQIDASVLKEKRPIVPIIDPASIPSQSEPTTEDAHKKASAREEQIKEVHDIEAKISGLKKKLADQLDTMSDDEDFLNIRTEAEELLNDFAEDVFQEISQTAPVATPPLASRKSPTPKTPTPIIHTPKDPPKDLAKVLPINVPNEVTKDLSRDKPKEPVQILPHIELNLPKRPIRERLGVRGTTKESTENKEKDKNKATLPPSPERLTPERQPEAKPEQHAKKYSGSTPEQPRRSSISEESPVEKTEQNKRPISKVSVLENQRQPRVSCASVVRVRPRPRVSAPASNLLMKAVADAHKSLLNAPPKIEPEQRKLQRALVLPMRRCIETQKIVIQVPRDAQPDTNNDVVSTNMENDGEEKNKNKPSINITINRDNDDVVTPVHITKVINNMDYVPARTASRRDDTLIIETKNKQKSNTKKHRDTQFIVTMDGFQPNAFLAKKLMMEGLLDDDDELAKTVIPKPAKSVLITKENEDEIKEKENNETVDKEAENKEENRMKQESPIANECASKLSESSEIIKNEPRDDEQKKTLDDTGDKSNNQKKRLSDASEESDTQVIIKKEPQQTGEKRKSVDVRSDDTSDKIVTPPVKKRKASPIVFNIEKKEKETERVRERTQSASSDGHVTITTSSSSHKFDSVPPLSVAERKLLWCRAFPLCRYGSACAFAHPRCKFAAGCTRRGCVYSHSPPTSPPAIVSVAERKLLWCRAFPLCRYGSACAFAHPRCKFAAGCTRRGCVYSHSPPTSPPAIASHVVPAANYKTISSGGAISICKYYPSCVNPACHFYHPKPCRYGKACTNKLECNFYHNDSPSAKWKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFF1</accession>
    <name>A0A0N1IFF1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFF1"/>
    <dbReference type="InParanoid" id="A0A0N1IFF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8562" checksum="02F03734E7C1426A" modified="2015-12-09" version="1">MLVRGCAGGELRHSLAERTKALAARYHALCSPAREESRSVDRSRTRHRKSQTRWYVKVSGDLGLNHLRRTVGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG45</accession>
    <name>A0A0N1IG45_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein mL62</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase ICT1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG45"/>
    <dbReference type="FunCoup" id="A0A0N1IG45">
        <property type="interactions" value="1265"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IG45"/>
    <dbReference type="InParanoid" id="A0A0N1IG45"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000046">
        <property type="entry name" value="Peptidyl-tRNA hydrolase ICT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="21568" checksum="1CB890CF40389108" modified="2015-12-09" version="1">MASIAFYSTLTKRTMAYKSAISLETLYPNSSLKLTTPSFTPDPKEKFSGFIPMEKLDITYSASSGPGGQNVNKVHTKVDLRFKLNEADWLHPDIKEKLLELHGKKLSKEGYLIIRSDTTRSQQLNLADCLQKLRKLIREAAVTQREPAPETQERIRQRHLKAARLRVAQKREESHRRELKRPPTVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG97</accession>
    <name>A0A0N1IG97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_05620</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG97"/>
    <dbReference type="FunCoup" id="A0A0N1IG97">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IG97"/>
    <dbReference type="InParanoid" id="A0A0N1IG97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="475"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="557"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="559"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="617"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ18441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="98691" checksum="989F6485BB8DA14B" modified="2015-12-09" version="1">MDTRDKKRVKVYVFKVEGCVGAAMDAARSPRGSPCAVSGEGTLEAVGVDEQFTFAIQFEVTAKNSLKVLIRPLGGGDVGAGVGSGVGARGGAEGEEEEEERGSSPLGPGGPHRCTQCRGAYPSRAQLERHETLHAPSTQTCKICHKSFQNVYRLQRHMLSHDESALLRKYKCNDCDKAFKFKHHLKEHLRIHSGEKPFECANCGKKFSHSGSYSSHTTSKKCLVMNLKMGRIKPNNPALNPNRSPARKRASASALVASHLNNNLLPNGGSFLHMLPKYNDATAFFASMSAQENFPRAPLPQPALNPFYLPGGVPLSPAAGIAPYSFPSTLSQLFERIASTQYHQRKIENVIDPKLSSPLAANPEDMIEEITEEDDKRSEGSAELVMDIEDEESVAIKRENESAENEYRPRSRDSICDSKNILDNSEHDLTTSPRIRKTENIFTERMKSGSPADGTFHEPPLSPGPTVKHEIVDDFVCYKCSLSFKDKNDLVEHERLVCGNLFRKHEGLAAQVAETVALNRLEAELQASTRGAGASDDDDTTTTREDRDDKMSIHDTDRKIRVRTALSEEQQQVLKEYYAVNSRPNREEFKKIAQQIGLDNRVVQVWFQNNRARVRRMTQPVAHSDQPLDLSTKKSSPSLASSPSPSSPGSAPATPGTPGTPGTCALSDCEEAVNLSQKSSRSTTPLRVQPGLVAPAPAPGYPHSNCSSSSFSDFMVSPSPTEIVLGHKRIYPKKMSVNPIIPMGTLLQYNDMVRVPAPSPGYERPERADRPAWDEAPLSADFDDDAALLKKKMKTELKEGEGQFVCNQCDKTFVKQSSLARHKYEHSGQRPYKCEECPKAFKHKHHLTEHKRLHTGEKPFQCCKCLKKFSHSGSYSQHMNHRFAICKPYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHH0</accession>
    <name>A0A0N1IHH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHH0"/>
    <dbReference type="InParanoid" id="A0A0N1IHH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9366" checksum="F93ADD6682069A5D" modified="2015-12-09" version="1">MRGGVRACGRVGACGACGGVRGVCDVGDVGAREARAKLCQYSHGPFATPGAAGRRDALVLGNPLRERTILFTLAPIIGDYASLFVFRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II85</accession>
    <name>A0A0N1II85_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01048243">
        <property type="protein sequence ID" value="KPJ21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II85"/>
    <dbReference type="STRING" id="76193.A0A0N1II85"/>
    <dbReference type="InParanoid" id="A0A0N1II85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11371" checksum="EAD387DF151F1DE7" modified="2015-12-09" version="1" fragment="single">NYDTYPVQYEQAVYRKPLREHEKPQDLRNVPGVPGVDYPIYHQVPDTRFSCAHVPVHPGMYANVETGCQVKRNNKLYYSFISHMLMCSMSLPRTLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIE0</accession>
    <name>A0A0N1IIE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIE0"/>
    <dbReference type="InParanoid" id="A0A0N1IIE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="6753" checksum="E796511546024017" modified="2015-12-09" version="1">MAARALFQPLFRGTRHIMRLMDVQSAVVFCDVSLHNKVAIRSTGVSMYRRVDVQDTLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1III9</accession>
    <name>A0A0N1III9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease snake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459802">
        <property type="protein sequence ID" value="KPJ19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1III9"/>
    <dbReference type="InParanoid" id="A0A0N1III9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="197" mass="22183" checksum="EF3A5677D7929D83" modified="2015-12-09" version="1">MWVFKCGGVLISEKFVLTAAHCSRMTSGDTTVTNITPQIVRFGIVNILGVDKNGVPPQDVPISRVIVHDKYHAPKRYYDIALIELIKNVEFTRSIHPACLWTKENEISGKGIVAGWGVVDTEEAFRTEYRPMKLRLSATLNEVETKIHNCRRLLVLTASASLSICRRLYGHQSAVVSTEIGTVCTNYYFKDLYQPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INL7</accession>
    <name>A0A0N1INL7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460971">
        <property type="protein sequence ID" value="KPJ10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INL7"/>
    <dbReference type="FunCoup" id="A0A0N1INL7">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INL7"/>
    <dbReference type="KEGG" id="pmac:106716090"/>
    <dbReference type="InParanoid" id="A0A0N1INL7"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.40:FF:000008">
        <property type="entry name" value="Oligopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000059">
        <property type="entry name" value="Oligopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="260"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="722" mass="83640" checksum="6F7A4F0C8CCE91D2" modified="2015-12-09" version="1">MASFILRRNIVSRHFKKPFYQNKRNAGYVVLIPEIGEDAEKNTLLLDNGLPEFNDVTIEKCIASISKQSMEYESGVKQVEQSAAECKNAFVEIFQPLEKLDSQLELTWGVTKTLYLGNSSLMPTKSYLQIHERAHKARSSKFTSIPIFKAAVNEKNRLKDLTDEEQRLLDKYILEGKLNGLDVKGVKRERLNSILTAIQKERHIFREKVNFATKAFKSTINDEEVVKEFPESLAKSMSLNNDASKGPWVVTLQPHIYEPFMQYCPDRVQRWNAWQGFVQRCSGYGNKELETSTILENIRSLRQEQATILGFDTYVDMSMETKMAGSIENVNNILDSLLESARPVQDVELEALQQFANERGLNSKLEHWDIPYWQRKQKWSLYNFDEDKIREYFPLPRVVNSLFNLCSTLFKIQIVERSNVQTWHKDVKFYDVFDESSNSPIAGFYFDPYARQNEKIRIYDDAGWHVSIRNKCAVTSTQPLSALIFNFQAPVEGKQSLLSFKEVTVLFQRFGHSLRHLLTKANYSEVAGLSNVEWDAAEVCGHVMTHWVYDPHTIHAISGHYNTEEPLPNEIVQNLHNVRRHMSGYELCKELYLSRLDLDLHSTKTFWRDLVRQMWPKYNVLPFDKYDSHPLSFTKIVSEEWGAAYYCHLWSKMIAADIFSAFDEARQSDEDILAVGRRYRDTFLAAGGACHPSEVFRRFRGRDPSPHALLKNLGLPKKIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP62</accession>
    <name>A0A0N1IP62_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460557">
        <property type="protein sequence ID" value="KPJ13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="680" mass="73190" checksum="C4DA1F9C15481191" modified="2015-12-09" version="1">MILQPASLDTVTLRQGARALGFEVLPSFCGHHQLAHIRFGSPAHASGAVHDGDEIVQVLHHHARHTSDTSHTPLHPYTPTPSLKYLEKIPQKFSPKVEDIYGSLVRHITKHDIRLVSTERRALPPINGEADAPQSPPAPAPGPAHMPVATPPSSASRALFTSSKTRSLKKKNSMLASQEARGERARGGGAGRRGGRRGGRRRVAAREGAHRSAAPLGAPPSAAGAQPALRLPLARRKYTALRTGREGAAQRSDGCPPVCPQCSRADCMIYLEGFTVCAAGEVKSRAHAFKVYHTGTAFYFACDSRDAMLAWIQLIHRATLLPSLLPHPTTTTTTATAGTEIFKQFSETDYSDTDSDTESSERRHDLRERERDRERERDKDKSKFGSLKKLTHRAQRSESQESVALTPGPGPGLGPGPALGPALGPAPAAASLDRKYLRFFSRHRAKDEHKPRKLGFDISAYLLSAGVMRHYELAPVTSTQLPQEYVKCLLIHIVIPPPPVTQCACPQELRAQLGRVVPDVTYGELRDPKRDPKRDLRQDPNKRVAHGHVHSGARPAPDSSWVSGGGEEAGSGAAGGAAGGAGDAAGGAAGGAASGPGVSRLRLMFGGARQVNDDYDERDTSAPHKVMLYTGEETCALQESGRGTYPHLQCPPTFQPESYSLAHAAARRPRTHRPAHAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPI6</accession>
    <name>A0A0N1IPI6_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">Cuticlin-1</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">RR48_02274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460324">
        <property type="protein sequence ID" value="KPJ15846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IPI6"/>
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        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
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        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="123"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="522" mass="57412" checksum="4FCAC01AD7063D71" modified="2015-12-09" version="1" fragment="single">STDQMAMESAERDTPSHAYNGPPPPVPPQHNRRQNPPHLQPHHALGMPRIPNHHQIHSKPFALGPPVNHLKNDIGSGFRGPPPQQTPPADSQTAASDKVFSGAGDVWPAPAPDMPKIVSLDVKCEKNAMRVFLSFDKPFFGIVFSKGHYSNHQCVHLPPNLGRASASFEIGAHACGTAGSGDPRYRGDVAAAGTYFENVIVIQYDPQVQEVWDQARKLRCTWHDQYEKAVTFRPFPVDMLDVVRADFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDDAKFDMLVRDCVAHDGQRAPIQLVDRRGCVTRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYRCPEQCSDGGHNLIAQHVEYGPPQIDSYPVGAEIRRDERRVRRQRRATSPEKEVGVNRVIRVVSAGDLNLDSTEENAAPKIVPTPGLVCMTTPGFAATLGTLLATLICSCAVSAILFFKLRPITSLKKKTAAIATLARPHPPAGPHIISKSRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPJ2</accession>
    <name>A0A0N1IPJ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460301">
        <property type="protein sequence ID" value="KPJ16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPJ2"/>
    <dbReference type="InParanoid" id="A0A0N1IPJ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7569" checksum="AAE540611346D115" modified="2015-12-09" version="1">MEKHDALDLWHEHAPVEVVECGETSRAFRQCGRSAPPRARTLAAAATIRRALHYTPYKNKQSFYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPN5</accession>
    <name>A0A0N1IPN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-1,4-mannosyltransferase egh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPN5"/>
    <dbReference type="FunCoup" id="A0A0N1IPN5">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPN5"/>
    <dbReference type="InParanoid" id="A0A0N1IPN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000175">
        <property type="entry name" value="Beta-1,4-mannosyltransferase bre-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="359" mass="41207" checksum="FE12279AE04D3111" modified="2015-12-09" version="1">MNTCIDVGMENFMIEVVTDKVISLPKHRRVREVVVPSEYKTKTGALFKSRALQYCLEDDVNILADTDWIVHLDEETLLTENSVRGILNFVFDGQHQFGQGLITYANEQIVNWLTTLADSFRVADDMGKLRFQFYLFHKPLFSWKGSYVVTQVGAEKKISFDNGLDGSVAEDCYFAMKAYMEGYTFNFIEGEMWEKSPFTLWDFMQQRKRWIQGILLVVHSKEIPFINKVFLGISCYSWVTLPLSTSNMLLAALCPIPCPQFLDLICGFIGAVNIYMYIFGVIKSFPIYRFGPLKFFLPSLGAVRCRESIASEVRQVPWQLGNGEEDSDKIMSDNEEEGLAIDPKLGYRVRFPSHIIRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ02</accession>
    <name>A0A0N1IQ02_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIP18 family protein CG30152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460047">
        <property type="protein sequence ID" value="KPJ17992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ02"/>
    <dbReference type="FunCoup" id="A0A0N1IQ02">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ02"/>
    <dbReference type="KEGG" id="pmac:106721721"/>
    <dbReference type="InParanoid" id="A0A0N1IQ02"/>
    <dbReference type="OMA" id="HELGYRN"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="19167" checksum="1930780F801E674F" modified="2015-12-09" version="1">MLSFFSKLSLNNAQNSPVELAKPAYMDKSATLQELGYKDDDELRETIYDFLRTIRDPEKPSTLEDLKVVYEEGIFVKEPTADKVPVLRVEYNPTVPHCSLATLIGLCIRIKILRSLHHPVKLDVFIKKGAHTTEDEINKQINDKERIAAAMENPNLRNLVENCIAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ23</accession>
    <name>A0A0N1IQ23_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ23"/>
    <dbReference type="STRING" id="76193.A0A0N1IQ23"/>
    <dbReference type="InParanoid" id="A0A0N1IQ23"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1184" mass="136731" checksum="F19BD4104837A26A" modified="2015-12-09" version="1">METTEQSGPCSNNQSIDASSNAPAATKPATTEIKPILSKGVENAKKRLRAFSIQKKTPIAPIIVPKPSSTGHTTVLIGKLSGAKPSTPKVDDEQKKLQRPPKPGSNKRPLTDPAKVDEIIKEAKKARDEGRKYKFDYQKLLPDYDNPFQRKKEEEKNKIVDFRDKDFDREKKRSDRYDNRRHSDYRREERDRYKYKDKEKGREKEKEDAKKDEKETNVNLNDYLVCDSWSLDNEEKASSPRVEDKTKNIIKHQTDTKYAKAITEQVRDSVLKKQDKLKEFTRDSPIRPIKMEKLQPVIDSFKFEIDPNDDEILDIFDIESGKEKYGLKSKDLSIYSPTDLKSEDYDQDISKDTTMDGNDDTFLESIINEIKQEDMSDDMSQDKGLVEYDSPIKEETHVQESDPRLSITPELDDKMKYQQSQRSDYSDGYRSSESGYKTSDTTESGYKSMDSFRLSIEKDLEESMEVKMSKSTVNSLETWNTTETRTEPKLWYTENPKLCNCVKDRGVVYEELNMCKMNLVDRVYGCDQIPDAPASKSRNWYPRPHLCLTETHTVPVSNEWEGDDISQTEVCTQDSDRRRSNTPLRSEEVLLDREYQRFMKAVWPEVETRNETPRSTTPVKEDVRKKKKDVEVEKEIEAKKKKEEGSSVKKMKQLSSEGWSQESDIEEEIEKSKKIKIDKEKLRKRKRSLSSLSSESEPDAKKRKKILKKKALKKTKSKSAKKRRIGKKILKKLKEKEKKKKKQSKIERIDESEDDDSGRKNVKKIKKKILQKKKKNLKRKKKEESTSSSSSSSSESSTDESQKKAKKKAESKKKKEKKRKRKTSTSDSAQSEELFDVNILNNIKTERLTDDEKTKTLINFSPRRQQKPREIINVKELQNDFVGNNIHIKKEVTEEYPLSPKVPESQKNATEEEKDQIVPNDKNENVPKITEVIDEEVKEQIEIKESQVNETPSPVKIPETSPNLIQQNIPPVETVSNIEVIPTISPIPQRCQIKPVMDESNMSLCSSQESVCSVKTYEKDDSHLRPSSQNSNYSFNDVISASQSGLYTKQIESVVECEENHETYQQDNYEMYEHLAMAYQSDVASQQASPPSVGGEQRIETVVRVRSRGEIKCDWRPGLAPPREHPPPDRPSRWGSTLKGTTRRRLGQAPNWVTGAIKQRENLVLHLAARNSILTLRRRMGEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHW4</accession>
    <name>A0A0N1PHW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460622">
        <property type="protein sequence ID" value="KPJ13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHW4"/>
    <dbReference type="STRING" id="76193.A0A0N1PHW4"/>
    <dbReference type="InParanoid" id="A0A0N1PHW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="34916" checksum="2E63C4C5C7DC6069" modified="2015-12-09" version="1">MKLSDKRNEFPPPQAAGNKATNNGIIKFPDEKGTVHVFNSTAKPNSKWLFNIGKFTNKYYLYTRANPQYEELIMDDISSITDSNFNSSNPTVVIVHGWTGNRDSNINIALRGAFTMIGDYNVIVLDWGKVAGKDYITSVEAVPRVGRYLGKFLSFLTSVTNVSISSLHLVGHSLGAHVVGNAGKELGGQVGRITGLDPAGPLWSLNSKRLSETDAIYVEALHTNAGFFGILEAVGRTDFYANGGFDQPGCLTDICSHERAWKVFASSLMFDNLVGYQCASLLQFTLDMCYGATLNFGNDELTKSGSGVYRLKTKSDFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIC9</accession>
    <name>A0A0N1PIC9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein OSCP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIC9"/>
    <dbReference type="STRING" id="76193.A0A0N1PIC9"/>
    <dbReference type="KEGG" id="pmac:106710223"/>
    <dbReference type="InParanoid" id="A0A0N1PIC9"/>
    <dbReference type="OrthoDB" id="2157380at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019332">
        <property type="entry name" value="OSCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439">
        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="303" mass="35022" checksum="3598E8BD634F1007" modified="2015-12-09" version="1">MSHFATPFIVINLGCEMIYVIDQRLKSQNIPMDKSGRVLTDIVTVLLHPKLQQELFLPQPVAAHSVIKQLLQDISAASIMKLDEYSMNKLWDLMTMILKWQISITNNHSIFDITRRHLKGVATLMPDNFSKSIFDDVLKQIQVLQEKMSDDAYKCLYNTILLWFSEYHTKISVLLRLGLQNKDGTFNSSTIINPKIAQNLGENIYKYDNKKDSLEEYDKHTSDNNEINCLLAHIETTKNSEKQSIQIKLPLEMEANSRRILNINKDYFEKIQTNVIERGNDLSFVADIPKSPQEDLLKMLNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIG4</accession>
    <name>A0A0N1PIG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">THAP domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_01911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIG4"/>
    <dbReference type="KEGG" id="pmac:106710508"/>
    <dbReference type="InParanoid" id="A0A0N1PIG4"/>
    <dbReference type="OMA" id="TEDCYHA"/>
    <dbReference type="OrthoDB" id="6496718at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ15350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="29445" checksum="673D009B20744EA8" modified="2015-12-09" version="1">MSSCAILWCGKNSRFSCTKTDEVTFHRFPKDSTIKKKWIEATKRDNWYPSNFSVICSRHFTEDCYHAKKPRRRLLDNAIPTLNLPVITFDSLINELESDQHLKASSHARRASAQEPISIMLPLQERDSPEPVTEAQIDYEELYKEITSYNVNRLCDRIIELKESVDRKDLNVRRLREQVRYFKRQIAIMEKTIKDLDEKCNINEENENFIVKITNPENGDVLYKYDITQDTKKTKKRNRKVKPKKDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ58</accession>
    <name>A0A0N1PJ58_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ459933">
        <property type="protein sequence ID" value="KPJ19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ58"/>
    <dbReference type="InParanoid" id="A0A0N1PJ58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001965">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000494">
        <property type="entry name" value="serine/threonine-protein kinase WNK2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056865">
        <property type="entry name" value="CCTL2_WNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24889">
        <property type="entry name" value="CCTL2_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="178"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="897"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1253"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1340"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1581"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2227"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1260"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1340"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1599"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1627"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2241"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2500" mass="274897" checksum="74C31D15DC6CF198" modified="2015-12-09" version="1">MASNVSVRNTKQRKDNLITRKQDKSPEKTIRGTRGAYRGIPSTSKRDEETDTGSSERLDRSKKFISQNKSSYGLGKRPEFLKNRNVHLASSRYGQMTSGLHGHGHQISQPAHHLDSTVLPTKEKTVHGKEKTFKVVMGGEVGVMKAPVLGPRPYNALAIIHTQQSNTFDMLNTLTTSVASQPVVGVGVGGFRRRSSGQGALASCDPELDDSGNKLVARLEDDAFISEQDLEENIQIATATEKGLPHADDTGGEQPQEQQNVFLSYCVYHGLDTQTGVAVAWCELLEKKLNKTERLRFREEADMLKKLQHPNIVRFYNYWEGTVAKKKNIVLITELMLSGTLKAYLRRFKKINPKVLKSWCRQILKGLNFLHSRTPPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNRSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATGEYPYSECSGPAQIYKKVCTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATGEYPYSECSGPAQIYKKVVSGVKPQSLDKVNIPEVKDIIESCIKPNKTDRPKVKDLLNHEFFGEDIGLRLEIVGRDLVTSSDITKIQFRLKIIDPKKRSYTHKENEAIQFEFDMEQDDCEEVANEMAKAGLIMEEDARIVYKLLKSQLISLNRERSEKKAQMLFNQELINEQNRQQLLLEQVKMFHNQQQASPVDQVKAGLLNGVGSQPTLAAVQLDQQSQFLQTQQQLLQQQYQQISNEETAMKILQHNLIQARISPSLTSLEQNIKQQQALMEHNLLNQQMLDQNVPAQLMEQQAQLEPVSSQQQLHQNNILNTQFGLNEITNQNQALQQHIIQQQQNIMRHQAAVIHQKQMEEQLTAQETAIAGPQPNLVTGQVLDPSLQNLQNILAQIIQRPDTLQSRKESESEQQQAMQQQQQTQQTPALSQQPTTESVDVPAPSIQQEQEALQQTMNLLGSQMQQATQNLGYQQNQQHFIQHNILSAAVDPGILAQQQQVAHAQQQMVQAQQQLNLQKQMLAQQQLVFQQHMLSQQQLHLPGQTLSPQHFRNTLFQQQQYLAQQERQLQTQQNIIDQQNLALLAQKQQLMGQQQQKVEEMLRAQRPVYQRQGSEQSQISTTDVHDQQQPLVQDQYQQKPPLQPQMSVDQMQQYQNQYIDMQMQKKEDHYIPQMHPLQGQSLPHNILAQNFSTVQQSERQISSHEGTPVQNYSVNPLQMYQQQSQPVQTMQNVSYQTDSTIPSSVAGAVQQNISHVQDSNQMHMQSMQQPPVQQPVQQSVQQTVQPSVQQSVQQPVQQSVQNTIQTSMQPSMQQSVQPSVQQNVQPSIQQSVQQTAQQTAQSSVQQSVQQPVQPSVQQSSQPTTQTSVQSSAQIQESIPHQLSISEPSDNGHINGGQKEQFLTPMTEFPSGSTHPDGIKPPELSSVEEKLGEAQQEAPISTAVPSPITSEKKSRGSKKRSREKDKLPKLTVLEVNDSATVVECQLESKSKTVTFKFDVTDVNPEEIASNLVSNNLLPEWQSVTFTELIRDIVQQLLSDPAATPVLSPAHHAALRLNMDKTDYDSETTEREENTASQDSIALAELADDDPVPTAPTPTPADTAPTPTPTPTPASAPAPAPAVPAHLPAEISSRKISTASSIGSNQSDGGSIPPDRSGSSESQNGEKKTQKPTRKISRFLVSPVVDRGEEVVEEKTEPERPPEPKLYSEVAKEPRKDAQYSVASQMQPPHTVTEQKLEVKQDIPISAPIAQSVVPPITAPIVNNIQPTIPPALPFQTPMINPNLLSGTLQTNLTNLSTPLQIATDTPLLGLSQVGTPIGVGADLGLGIGLGPVGPTLADPVGLSRLPFAQPALAPTPSLTDALPNAENIQRMLLKQNIMNQQQNLTGPNLLGLLNQQQYPQPDLALHNNLLTNAQPACGTIAGARLPGHYTPQKYYQPMLACAATANDFIAQQQALQGSVCPLGAPTLGGGFPLGLGLGTPMLQHQLAAHNLALNQNLMGQNLGQNLGLATQNLGVGGQNLMGGQKFGVGGPALSLVGAGQLHRAAHAHHTLARRAVDLDGAAQQQALQGSVCPLGAPTLGGGFPLGLGLGTPMLQHQLAAHNLALNQNLMGQNLGQNLGLATQNLGVGGQNLMGGQKFGVGGPALSLVGAGQLHRAAHAHHAHHTLARRAVDLDGAGMTNVNSTGSSQPSTPNKSQSYEYMLSLQQKLSSIANSGPVSPQSPLEYSPMLSPTQRAMHAMPTHKTGEGSEAPGSEAGEGPEVGGAVGVVGGVAAHASRLAHLDHELSKISLHYKHAPNKDVFMEHGAEEHEIMSDNVNDGAGSAYEGAKEKPYLDKTAKRPMLVDVYNKFEECRCFIYLKLIEDTDPKQAAEEISEDKERSFLIVDPARDMTCTVLARTLDLERDSAFDRFIERTYSQHEHTPEEKSESVSVTEELNKWRGVEVEGQTWREGAEVSGAGLCGAGAGPRPARAQVGALLADVLVDDVLTDRAWCRQVVLLSLRTAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJL8</accession>
    <name>A0A0N1PJL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-sulfoglucosamine sulfohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJL8"/>
    <dbReference type="FunCoup" id="A0A0N1PJL8">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJL8"/>
    <dbReference type="InParanoid" id="A0A0N1PJL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="115"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="7">
        <location>
            <begin position="520"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="597" mass="67370" checksum="46703EE0B6264A80" modified="2015-12-09" version="1">MRCRGLVKVPSTSNKYKIFLRLLIAADRVQFARLLIEIKVARSISIPEAPVAVEGSEATVPALSAAPSCQLNTLPPLRGRHVNSRLSHNMARAPAVFYVLLCLLITERVLSNKARNVLILLADDGGFELGAYGNKICQTPNIDALARRGLLFNNAFNSVSSCSTSRAALLTGTPSHQSGMYGLHHGVHHFNAFDNLTSLPNLLRQNGVYTGIIGKKHVGPDDVFRFDYEQTERNNHIDQVGRNITHIKLLARDFLANANRDNKSFFLYVGFHDPHRCGHSEPQYGAFCERFGSGEPGMGTIPDWAPWYYQWDEVQLPYHVQDTEAARRDIAAQYTTMSRLDQGVGLILKELEAAGHKEDTLVIYTSDNGIPFPGGRTNLHEAGVRAPLLVASPEPGARRNQASYAMASQLDLMPTVLDWFGISTERAEDNEVTHGDEPKSLLPILIKEPAYSEAEAVFASQTHHEVTMYYPMRAVRTRRYKLLHNLHHAMPFPIDQDLYVSPTFQDILNRTRSKRPLPWYKTLRQYYYRPQWELYDLRRDPAELNNLHGKPSLTEVEAELRARLQSWQRRTRDPWRCAPAGVLDHDQCFALDNGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKR1</accession>
    <name>A0A194QKR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Myosin-VI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_14426</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QKR1">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QKR1"/>
    <dbReference type="InParanoid" id="A0A194QKR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01382">
        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000018">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1317"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1379"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1409"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="57"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="863"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="863"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KPJ05984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1566" mass="180070" checksum="C62E5B2E094A5BA9" modified="2016-10-05" version="1">MTLEQQLVWVREGSEGFVLARLHELLGEEADVVPLDSKHARRVANFDDILPAGDPDKEVDDNCELMFLNEATLLNNIICRYKKKKIYTYVANILLAVNPYEDIPDLYSSATIKKYQGRSLGELPPHVFAIADKAFRDMKSFKQSQSIIVSGESGAGKTESTKYILKYLCDLWAKGAGPVEQKILDANPILEAFGNAKTTRNNNSSRFGKFMEVHFSAKYQVVGGHISHYLLEKSRICTQSAEERNYHVFYLLCAGAPQELRAALKITKPDDYQYLKNGCTQYFTSAGSEKKISASQKSKQQAAKGGLRDPILDDVEDFQRLHQALSRVGLTEEEKRSVYSVVAAVLHLGNVEFEEDGGARGGCSVAQHSEPALAAAAHLLGVDAAELRMALVSRLMQSSRGGLKGTAIMVPLKPYEAMNARDALAKAVYSKLFDYIVHRINASIPFQASAYYIGVLDIAGFEYFQMNSFEQFCINYCNEKLQQFFNERILKNEQDLYKREGLNVPEIRFVDNQDCIDLIESKNHGIFHLLDEESKLPKPEFGHFTHSVHKQLGGNATSSRLQVPRSSRLKAHRILRDDEGFLLRHFAGAVCYNTNQFIEKNNDALHASLEFLVQESSCSLVQQLFLTSDNNNAKGKLNFISVGAKFQAQLSQLMDKLKENAIVHSFGLSDKDYKFGVTRLFFRPGKYSEFDTIMRSDPDNLKAIVDSVLAWLVKSRWRRSIFAALSVIKLKNKILYRRECLLLLQKTIRGYLVRRQHRPRYQGIAKIKAIEDSLKKMESVTAQLNKEKETAKKNIENLRNSIRNACALIKSNEKISRTEIDQLYNKLSKDAESQMAALQKAMTDQKNREEQERLRKIEAEMRAAEEAKMKEQERIQQEEEHRRLKAEMESRRKAEEAARLQQEQRDRAAAAQLQRQLEQAAQADLENRDRLEQERRDHEMAMRLAEETNGHVEGSPPQLRSFPTMDTMNGENKLNRSERVRMQQAMAGKQKYDLSKWKYSELRDTINTSCDIELLEACRHEFHRRLKVYHAWKAKNARKTTMHEQERAPQSIMDAAKAPRVSGREVLGARHRYFRIPFVRPGGGERRGWWYAHFDGRYVARQMELHPDKTPVLLQAGIDDMQMCELSLEETGLTRKRGAEILEHEFEREWARHNGPPYRALDRISAFKCAFTGSYVVHWLGGPTIIDREIKPNKETIDIYCYSGCNKNLFVLWQTVKFNLKIKNDEFNQYIGENPEDVYKDYNENSYGWAVVNPFQKKSYKSISIDLFTPTCMAIDTKHRHSIELHIQRVDMWRVLLMALGLVLIFSSKALSGNPVFFYVCGVLVGVSASFLLLVYYFSKLLSRKTLTYGILIGGWTVGVYLIRQAWENVQSILMSYQVYMFYYTLIVTFVSFVVCYRIGPPKNQRSKNLVMWTLQVIGAIMIFFSSQYREASTMVCVLALCIKYFPQTWLYRVQAYWRRKFPPQRRLLTSEEYYEEGARETKRALDNLRQYCSSPDCKQWSVIMKISDAKRFASFVEGNSHLSDDEVMDYESYAFSLERDKPVANSTRAYDISDDDSSTDDEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLR2</accession>
    <name>A0A194QLR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLR2"/>
    <dbReference type="STRING" id="76193.A0A194QLR2"/>
    <dbReference type="KEGG" id="pmac:106719978"/>
    <dbReference type="InParanoid" id="A0A194QLR2"/>
    <dbReference type="OrthoDB" id="6616165at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25818" checksum="50D6C86FC66229E2" modified="2016-10-05" version="1">MTFDTERFITEIENRPAIWDTSSDEYSNRHLKKKSWEEVVQIFKEKDGMTKQEKKYMGDVLQKKWKSIRGCFMREIARQKAVRSGNGVGPRKSEYIYFKQLKFLKKVMVTRQSTQPSEIEEEHSQNDLDTDQSRPQQQHLNKGINSESGNDPLQEFLYKPIEQRDSYDFAEQDEDKMFLLSLVSTLKKVPEHKKIATKIRMMSLLEEATQTTSHTYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMJ8</accession>
    <name>A0A194QMJ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMJ8"/>
    <dbReference type="FunCoup" id="A0A194QMJ8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMJ8"/>
    <dbReference type="InParanoid" id="A0A194QMJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09501">
        <property type="entry name" value="SAM_SARM1-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09502">
        <property type="entry name" value="SAM_SARM1-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000056">
        <property type="entry name" value="Ectoderm-expressed 4, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000043">
        <property type="entry name" value="Sterile alpha and TIR motif-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000012">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="856"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1164"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ06180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1192" mass="131275" checksum="E425B80365885E6D" modified="2016-10-05" version="1">MENLKKSSLVSRQNQTLNTQVTSSSSQQMVSSTTSSSAATSQRLQSSSQRLQHMTASEMKASSMKSDLTELKSSISEMKNLSSCSALNFGQRLRSSMENIVDQDDGHLADIRDLDEIGDYSDMGDIGDMGGDAPLVTFPESDTPPPVSDKACMLAGNNVPVAVGGGGNGAPNELKYSAARVTSASSTRVVADGYSASRSAANSARLRRLQHGDLQYAERSAAGASHRLLQAEGLTAEQNDAYLQKGAPKDATSRVQDDRYSTTPGRPTQGDDRETLSALASALSLLATDSWGEQHGTFLEHGAHHSVDHESAQARRIPASGENRRATAREHTRAARGSGIAVLRTRSDTRIADFKFRSGMSGGGSVPWPVHRRVLSRYPAVPLGPSEQRSLKAGEVSAQEANNMSASSSRLQTEAFSAEKKAMASAQARQTVTSSGMFSHKEHSSVAHSNMTISSKNLSTKSTLLSSQMSQLLNGAIKPGDEDLTNLTFDDLDKLNANSNQKDVDLAIQKYSSRMNAFINSIKNNQMDIKNASVHFNKLNEMMRRAWAVPTYGHELGYSLCNTLRTSGGLDILMENCLETNNPELQFSSAKLLEQCLTTENRAHVVENGLEKVVNVACVCSKYANSVEHSRIRTGILEHLFKHSEGTCSDVIKLGGLDAVLFECRKNDIETLRHCATALANLSLYGGAENQEAMIKRKVPMWLFPLAFHTDDNVKYYACLAIAVLVANKEIEAAVLKSGTLDLVEPFVTSHNPSEFAKSNLSHAHGQSKNWLQKLVPVLSSKREEARNLAAFHFCMEAGIKKQQGNTEIFREIGAIESLKKVASCPNAVASKYAAQALRLIGEEVPHKLSQQVPLWSIEDVKEWVKQIGFSEYANNFQESRVDGDLLLQISEDNLKEDIGLLNGIKRKRFTRELQQLKKMADYSSRDTGSLNEFLQTIGPEYTIYTYSMLNAGVDKESMRGLSDEQLENECHIVNSIHRLRILNAIRVYESTLPSKGEENMEKNLDVFVSYRRSNGSQLASLLKVHLQLRGFTVFIDVERLEAGKFDNNLLQSIRQAKNFLLVLTPNALERCKHDTEQKDWVHREIVAALQSKCNIVPIIDNFEWPEPEELPEDMRAVCHFNGVRWIHDYQDACVEKLESFLRGKSNLANRLEGGLRGRGDVATPGTAAIGRGPPSYQRMASCESRASDKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNR0</accession>
    <name>A0A194QNR0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNR0"/>
    <dbReference type="STRING" id="76193.A0A194QNR0"/>
    <dbReference type="KEGG" id="pmac:106719158"/>
    <dbReference type="InParanoid" id="A0A194QNR0"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264518" description="Lipase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="47247" checksum="E8230D5356FEF4DD" modified="2016-10-05" version="1">MSGRILLLLVVGVTIVSAESPQSDYIDELVRTERYSQRFSNDVKEDAKLDVPELIIKYKYPLEVHEVTTPDGYILQMHRIPHGRDKNNVPGTKRPVVFLMHGLLCSSADWIISGPGSAFGYILVEEGFDVWMGNARGNYYSRNHVELNPDNTDFWDFSWDEIGNIDLPIMIDYALAVTGNEKIHYVGHSQGSTAFLVLCSLRPEYNDKIISMHSFSPVAFMAHNESPVLNAIAPFANSIKILASLIGIGEILPNTLLLTWAGQIFCKDHAITQEICSNILFAVGGWNDAHLNTTMIPVIFGHTPAGSSVKQFAHYGQSIASKEFRRYDHGIVKNIRLYGRRSPPKYNLSNIVVPIFFYYSDNDPLSQSKDVYRLYEELGSESKVLLPLPSFGHLDYLWGIDVKPLLYDTVIQLMGVVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNT4</accession>
    <name>A0A194QNT4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNT4"/>
    <dbReference type="KEGG" id="pmac:106719667"/>
    <dbReference type="InParanoid" id="A0A194QNT4"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443721" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="87"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="294" mass="33573" checksum="57EA13924E27D732" modified="2016-10-05" version="1">MLRAVVVLCVVGLAAASPVLVRTDEEVQAFRDFLESTKSDDASQFIARSRASPSDNAEENSGKYQGDIVLDDVTIESMVKEYAMGRNAYVYPGTKWPENTVVWEYAEDQFDDIHKAAIEDGIKHIENSTCIKFRYRQPEDTNYVSLTGLPNGCYAHVGYWEERGVHTMNLALNTPGVGCFRHGTIVHEFMHIIGFFHMQSTHDRDDYVHIATENIIDGMEHNFDIYTSELVNNLDIEYDYVSCLHYGPRAFSANGEDTIIPLREHEGVMGQRVYITDKDWLRINRHYNCQGAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ69</accession>
    <name>A0A194QQ69_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ69"/>
    <dbReference type="FunCoup" id="A0A194QQ69">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQ69"/>
    <dbReference type="InParanoid" id="A0A194QQ69"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16541">
        <property type="entry name" value="RING-HC_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000133">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057987">
        <property type="entry name" value="TPR_RNF123/RKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25576">
        <property type="entry name" value="TPR_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132967" checksum="14FBF1E33D32C7C8" modified="2016-10-05" version="1">MQKHDAVDDRAGRIGPKIVVFDASTGTGRLVLVGDERVSVQGLSSFATIRATACVYSGRWMYEAQLGTKGIMQIGWCTAGCTFSMDTGVGDTVNSYAYDGGRVRRWNVATSPYGQAWLPGDVIGSCLDLDKGTLEFYRNGVSMGVAFDNVAHGTGVAYFPAVSLAMQEHLYANFGHVPFVFPVEGFSPLQAPPTKECARATLLFKSLDAIIDELIHLSSFKTVDKKSSKAKSETSKAAEEEIAVRIDSSNSVYSPLGSPTNVLEAQGNEVKRMSRKAFLMSLARLVVIELGVCLKMSYVVIGELLTRFRGYLGLRSRSVNLDPQTAEFYSNIKAKDYEGLSEKILTQPHPKLCTLLDLLWTFLDESALCDIFEHCIVRECLLFDSVSPVKFDNFLNVKCPDESVLRTVIQKPWWQRPMSVKGETDPIIADNELNPATEDDIAVEARYKDDCAKITEAIRPLENIQLEFVLILFDNSDGSNVVPSTRKIFLEKFRRYIMDNCILDMRLFNVSRNSPAISWCCHARLLTAVLKLWNTENPLGNLTGPPHLPPKSFIDGELDFYNVDRLGGVLPFLVRTLRQDLVDVLGEDNPFIQSFEPNYNRAGGIDAGVSEMAAGSPALATLPQVISSMARFMHAAMPPMPNRTTGETALALKGTRSMMPGAGAIDVRSAYLRLLDGLLALYHGAGIKHAEKLCELRDSQLDLADCLHDIEQRISTVSTELQDGVGSKMELSESDKIQKQLMERMLKELERSKSVYEEKLMSGALQMAWVIGAIWTKQRQQELAIHFAGTLHSLRLSSDPDYAHHIEVASKEILPGKSSLLGNSSYASLQLEYTSSSDQSPQSQTSRVPTPRQGSQVQINSVTTHEGPRGFAESLFAFVPEYHVDAMLELCNTLRLYMHPTISINEIVEWEDMMVSCAAFLCAEFADQRIVLASTRESLVQTLAFGDREPTVNNMGAKVDAGLMSQCFGPCPSEVIQGRIRDYLAANPKDAASFLNSLLSQLNWAFSEFITMMQEILMAVISRVCVRGGGGAGFARLVARGLPDTDRVHYYVALAPVAGCLIRLLEPELSADHLIKVSKAIVSEPLFRIDGLEFMLGKSEENQFSFYNYPDDVTTEELTALEDVVSRLRVARDAVIKVSSPGSSGTQSELLCTICYARPADTAFVPCGHHSCRPCIMQHLLNSKQCFFCKADIESVREIEATNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQD2</accession>
    <name>A0A194QQD2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger MYND domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQD2"/>
    <dbReference type="FunCoup" id="A0A194QQD2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQD2"/>
    <dbReference type="InParanoid" id="A0A194QQD2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="49419" checksum="71B7EF14ADD6E641" modified="2016-10-05" version="1">MEPTEIENIGNSAWIDWHTRLQKLNQQAVLEASSMMEEATKETLISHGKLPVLVHEAICIQVWRLKIYPQMMKLEPAPASTFGIYMVLYHEAAAVGLLETVLFHEDGVQCISDVIIDLLQYATEQLTSLIALLNDGYLKPLSGQEMDSETVIEELERQKRDLQFDISMRCISIVRYLAEHMEAAGSGVSIATNLYKTNDVPSILCHLLQLEPWKKVNDKGDLQVFNFGRWSKPSVDDLSQIHRSEAQLWLCLRQLLLEPRLRHFYVIDEVRRTAFCRLQSKMTEEKIDQIPPLGELKTFLCQMAMGDYSSLHNRGNGVKAPGCTVIELVPQIKNAYLRQVHKRKKTLAANQLKNCFVDGSDESRRMAKKLLESYTSDAALALDSGGAKCAKCGDKANKKCSRCKSEWYCGRECQVQQWAKHKDICDQFAKLHVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR44</accession>
    <name>A0A194QR44_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR44"/>
    <dbReference type="FunCoup" id="A0A194QR44">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR44"/>
    <dbReference type="KEGG" id="pmac:106720241"/>
    <dbReference type="InParanoid" id="A0A194QR44"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000002">
        <property type="entry name" value="Frataxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ06001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="20439" checksum="FCD3FFE37405B882" modified="2016-10-05" version="1">MIRNFFRTSRWLVLRQINNFTPIVLNQCVPLNNCKTSSCLPNRTFLRNSSNSSQTSELVDPVVYEEICNETLESLCDYFEEIVDQSSNLKGADVTYSDGVLTVALGPEYGTYVINRQSPNKQIWLSSPVSGPKRYDLILKDGGYWMYKHDGVTLHKLLQDEISKIVVTKVDFGSCSHAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSK8</accession>
    <name>A0A194QSK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-methyldopa hypersensitive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSK8"/>
    <dbReference type="SMR" id="A0A194QSK8"/>
    <dbReference type="STRING" id="76193.A0A194QSK8"/>
    <dbReference type="InParanoid" id="A0A194QSK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="501" mass="56665" checksum="467E2060B1E1DB87" modified="2016-10-05" version="1">MDSKQFREFGKAAIDILADYYDHIRDRNVLPSVEPGQLLRQMSEDAPEKPCDWQDVLKDFTEMILPGTTHWHHPQFHAYYPTGISYASIVGNLLSDGLGVIGFNWIASPACTELEVVTMNWLGKLLGLPEEFLNCSSGPGGGIIQGSASESTLVGLLAAKDKMIRRLIKENPDLDPDDIRNKLVAYTSDQCNSSVEKAGVLGSMKMRLLKSDAYGKLRGDTLKKAFEDDVAEGLIPCYVVANLGTTGTCAFDPLYELGPICKENNVWLHVDAAYAGSAFICPEYREFMRGVEYADSFDMNAHKWLLVNFDCSAMWVRDGYDLINAFDVQRIYLDDVKTSLKIPDYRHWQMPLGRRFRSLKLWSVMKTYGAEGLRSHIRNHISLAQHFAKLVKSDERFVVEPEPSMGLVCFRLKDGENLTKKMLENLTAKKKVFMVAASYRGRYIIRWVICSLFTTKEDVEFSWKNIKHEADIICLNNKSVKSKISNIESIESVSISEEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTD0</accession>
    <name>A0A194QTD0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTD0"/>
    <dbReference type="STRING" id="76193.A0A194QTD0"/>
    <dbReference type="InParanoid" id="A0A194QTD0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="493" mass="55937" checksum="5F517289984D66A1" modified="2016-10-05" version="1">MSLIKLPMAWYQLNIIFMAPPQQFWCAKPPAFEKYTDEEWRKISVPVIMEYPCLIFDPDILLIAPKMDRHIIPLVACQKFVYDKTFFKRTLTSDFGLVCTKRWYINMSQCVMMTGIVVGGLVFGSIADKYGRKKPLMLAIVIQATGSYLVSFAPYYWTFLVVWFILAFGCGGIAIISFVICMEVVSGRWRTYIPVVYQLPFGLGNVVLALLSYWLRDWRKIEFALATVSLIYLLYWFWLPESPRWLLAVGKYDEAVEVFKKIVVENKRDVGDIRAIVALLPKKKKNDKLHLQFSDLMKSKNMRRKTIILSLIWFFTGLSYFTFSQYLGLIGSSIFLLVSMSGIISIPGGLLCLFILAKLGRKTTLNLFQILATVCFFAIYIFPKEDAKKAGIRLFFAGLGFAAIAGTVPALYLYTGELFPTVGRNVGVGGVTTFARIASMIAPLLVHLDVYIPGLPLLLVIFISAGQIFLVFPLPETRNKPIPDSLEEAEQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTD7</accession>
    <name>A0A194QTD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTD7"/>
    <dbReference type="STRING" id="76193.A0A194QTD7"/>
    <dbReference type="InParanoid" id="A0A194QTD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="17149" checksum="B6D6EA973369EEB1" modified="2016-10-05" version="1">MSDEESVDIKQELLDLLTNVQPNLQDVIKRSFTNVILQQNKNGEQIKPDVLEDTSYFAKNTQVNLTRLELLRTPTFHLQTVSLNLKSMALSLKCSLGETKSQDLPLTAAVSLPLYALLRHRLQRHLALVLRQATSVSDLLYSNPSMLEVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU06</accession>
    <name>A0A194QU06_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU06"/>
    <dbReference type="InParanoid" id="A0A194QU06"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="13229" checksum="6D71AFD7C8185B38" modified="2016-10-05" version="1">MRPLLVLHILKQCFVAFIEKHAPSFVMIAGDRVRKASACRDFEGVIERTGGERRGRITPQATRCRTATNLAAARAPPTYSRRGCARAPPPPPPPPPTPPAGTSSPLDSLSTSVPFSARTRANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU56</accession>
    <name>A0A194QU56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU56"/>
    <dbReference type="KEGG" id="pmac:106717484"/>
    <dbReference type="InParanoid" id="A0A194QU56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="25555" checksum="1891931E0F01B911" modified="2016-10-05" version="1">MDFSFYFGDKYKDLLTKQDPNMQTFSSLFSPQHDLPLDEPCPCSNLRQLKDPFATHPSEILNKILMSNDLFSFNKELTSTLCCDSHESIREDGVFFEFSPKHNQMLASTIPTNAMFSPLTKVLENLLGKRNIIPMDSIKPPALDIFLMPKKKSAIDGESDSILKKKPAIHAVGDNDINENIKMTPQFTNKSSVKKDLAKKKPDEDRKFDADPKLDHTSTEKSIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU86</accession>
    <name>A0A194QU86_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">RR48_12303</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">Ya'a_city_454_Pm</strain>
            <tissue evidence="36">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU86"/>
    <dbReference type="KEGG" id="pmac:106717792"/>
    <dbReference type="InParanoid" id="A0A194QU86"/>
    <dbReference type="OMA" id="DKVMGMT"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="35"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KPJ08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="355" mass="39169" checksum="68983F8E54F5271E" modified="2016-10-05" version="1">MYNNVNFLSIARRFYSGHVGKTEARKYVLTKHFQGEPKKSDFEIVQEELPELKDGEILTEAEYLSVDPYMRAYMIGYKLPTVMIGGQVAKITASRNDKYPVGGYVAGYFGWRTHTICNPNIPAKGALVPMYLLPDISPYPVSLALGVLGMPGNTAYFGLQEICKPKAGETIAITGAAGAVGSHVGQIGKILGCRVIGFAGSDAKCEYLEKELGFDRAFNYKTVNIQKALREGAPDRIDCYFDNVGGEISSAIMNYMNKNGRVAVCGSVSSYNDSALPKVTIVQPSIVFKELKVEGFLVNRWIDRWNDGINANLAWLREGKLKYEEKVYHGFDNMVEALVGMLRGENLGKAVVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUC0</accession>
    <name>A0A194QUC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUC0"/>
    <dbReference type="FunCoup" id="A0A194QUC0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUC0"/>
    <dbReference type="KEGG" id="pmac:106717198"/>
    <dbReference type="InParanoid" id="A0A194QUC0"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="17187" checksum="EB0F9F1DE4A69A42" modified="2016-10-05" version="1">MSEEEVTWTGERKNKDLRTFPSCSSFDLLDPHDPILSRLATQMFKRNNDYLQGEIATGQEHYDLLEEINRMVITKYANLQSLAINVNRSLNESNGKYEIEVKPLLEQIEDIDIELSALEATAFRLDSYTKQLLGRFIELLGIDTHSTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUD0</accession>
    <name>A0A194QUD0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_15213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUD0"/>
    <dbReference type="FunCoup" id="A0A194QUD0">
        <property type="interactions" value="1607"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUD0"/>
    <dbReference type="KEGG" id="pmac:106717121"/>
    <dbReference type="InParanoid" id="A0A194QUD0"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="328" mass="38529" checksum="4438239B61030098" modified="2016-10-05" version="1">MAKEITPLQLFTSYKKWVVNNPGIVTDLETITTWSSYFIAGKINKSPIVSELVYTLSKLLSLFNDRVIRDAYDGDFQHYGFRDQVKLWLTIVHYCEVFIELTVKNKWGNRGKWVATTLIQTFKCCSALILLYRFKELPIQHPPIPALQRKKFTEERESDDSANSYFTLKRSGRVLRRVDGAPPIALRDWQRVKIKDNKTTNIEIKDLVHAELLYILRPMVHLAAMRAFGTTTWKQWLVALGLDLASFKLYNRHMKELTYEQRIEISRRKLGFILYLLRSPMYNGYSKNVIENVLTSMSNKIPAMSFVCDPIIRYLSHWQDIYFYMWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVN2</accession>
    <name>A0A194QVN2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVN2"/>
    <dbReference type="FunCoup" id="A0A194QVN2">
        <property type="interactions" value="1293"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVN2"/>
    <dbReference type="InParanoid" id="A0A194QVN2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="215" mass="24403" checksum="A121C4BB9EA6C550" modified="2016-10-05" version="1">MRRMASIRKYIDIGANLTDEMYQGVYHASKKHEPDLDRVLERSWANGMYKMIITGGSSIDSKKAIDLSYTDLDILKQNKDDIVGGVVHSFDGPQDSLEKILELGMYIGINGCSLRTKENLEVVRKIPQDRLMIETDCPWCEVKPTHPGYTHVVTKFPAVKKEKYSIDSGNQVKGRNEPVNIVQVLEILAAVRKENIDELAEAIFNNTNKLFFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY2</accession>
    <name>A0A194QVY2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stomatin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVY2"/>
    <dbReference type="FunCoup" id="A0A194QVY2">
        <property type="interactions" value="1971"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVY2"/>
    <dbReference type="KEGG" id="pmac:106716604"/>
    <dbReference type="InParanoid" id="A0A194QVY2"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="398" mass="44483" checksum="62E1336ACE8758E3" modified="2016-10-05" version="1">MFTRSKFVLSRALPLKNVFKLEHQNEANFLYSIATRHRSTTPINTLIMFVPQQEAWIVERMGKFHRLLEPGLNLLWPIVDKIKYVQSLKEIAIDVPKQSAITSDNVTLGIDGVLYLRIIDPYLASYGVEDPEFAITQLAQTTMRSELGKISLDKVFRERESLNVSIVDAINKASEAWGITCLRYEIRDIKLPTRVHEAMQMQVEAERKKRAAILESEGVRAADINVAEGKRQARILASEAEKQEQINKASGEAQAMIAVADARARGLKLLAGALAQQDSKYAASLTLAEQYVAAFNKLARTNNTLILPANAGDVSSLVAQAMSIYSTISAQNKHQNQPSIEIYDNPIHSLTEKGTTLAGQPVVDDSLAEYFSDDEEREKALQLQKEKKQSQQNIEKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX54</accession>
    <name>A0A194QX54_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX54"/>
    <dbReference type="FunCoup" id="A0A194QX54">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QX54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000015">
        <property type="entry name" value="Nudix hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="251" mass="28868" checksum="E90B1CC14C1891FF" modified="2016-10-05" version="1">MTYAFIIVVSVAVTLKLLFLSFSLYVTLNDREPQTEKDSKIKNENTTCMVSKWKQVSQEGFNFHHSGESFVTLFKWLPKDSTSNLPPICHTSIGVGGLVFNDNNQILVVMEQLYDYPHWKLPGGYVEKGEDIKDTAVREVKEETGIDAVFQSMVTLRHTHKMMFGNSDIYIVVSLKATSDVITKSDDEIKDCKWMDIEEFLEHPHVHEFNRFILKQALDLKERKLKLSLKKSKVTISKFSREITSLIVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXN3</accession>
    <name>A0A194QXN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein CG32809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXN3"/>
    <dbReference type="InParanoid" id="A0A194QXN3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="374" mass="42738" checksum="8DD892FC54F558E1" modified="2016-10-05" version="1">MCQIIVCTSCICKVLMDSEWVRNVVSCIWYYLSCKPCRQTPDVEAAEGTTANLNNDNNFDSEIEMVTYNVTETEVTPPDEEEEEEEEFVERNILVHFTLPSTLPVILETASNEDSNSVDGGLSDGEAGRVPPRGRPSRREDPRRHTLAGNHLYLHPHHPNQINSLELERNAPVTTAKNMPEYATVTKYRDVNQKMLDPRMRKHPLQRNYPPTNNALLFEDDPGVMSEVETASTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRNETKRALLPNEITSIDTVKALFVRSFPKQLTMQYMESPMVKIYIHDSSKDMFYELEDVRAVLRSISCALYGVQWENCISIYRVLGIAVRDVPVYGIRFESYLCVKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXT7</accession>
    <name>A0A194QXT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium-activated potassium channel slowpoke</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXT7"/>
    <dbReference type="STRING" id="76193.A0A194QXT7"/>
    <dbReference type="InParanoid" id="A0A194QXT7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12680" checksum="C8E271795750AE6F" modified="2016-10-05" version="1">MASSEEEVTTASSSPEDDCLSVRKWWCFLLSSIITFITGLFIVGVWRCCAYACCRKEPELSPNDPKQKEQKAARQGKQEFEGTFMTEAKDWAGELISGQTTTGRILVRLIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXT9</accession>
    <name>A0A194QXT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXT9"/>
    <dbReference type="InParanoid" id="A0A194QXT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="19841" checksum="6CD110F223C08F3F" modified="2016-10-05" version="1">MSLSSRNDQKSVKSSAYDNLEEGIKFLIRSKHDGRRCDSDEKMKKQYLIESLRMHIPKKKIKLLLRDEKSGTTEAPVTPRNKNFLAELVEAELKYALEKKSSALYDRPVVEQMGRNDFLVINPGDMDPFVTVIPNDIYYNHEKTCVNWLEDCSYQGMRARLWQKLKSHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZR6</accession>
    <name>A0A194QZR6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMRFamide-related neuropeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZR6"/>
    <dbReference type="FunCoup" id="A0A194QZR6">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106715210"/>
    <dbReference type="InParanoid" id="A0A194QZR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264767" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="8077" checksum="A151B75EA74D200F" modified="2016-10-05" version="1">MRAVVVFCFIALIICLITLIEGNYRKPPFNGSIFGKRGNTENDATERAMSALCEIASETCQTWFSQISENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0S6</accession>
    <name>A0A194R0S6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0S6"/>
    <dbReference type="InParanoid" id="A0A194R0S6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264805" description="Cuticular protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="20416" checksum="7379898D24A5C333" modified="2016-10-05" version="1">MARLAVVALAFGLFVCIHAAPGYGGGSSGGGFGGGGGGGGGGFGGGGGFGGGSGGGGGFGGGKGGGGGLGGGLGGGNGGGHGGGLGGGNGGGLGGGSGGGLGGGNGGGHGGGLGGGKGGGLGGGHGGGLGGGNGGEKSGGYEKSGYEIEDGDYEDKSNEKDASISGETRSCDESVHIRKIPQTYENENNYRNRNHKFGYSASSSAAASADASAKAHEHGHKDSIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0U1</accession>
    <name>A0A194R0U1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epidermal retinol dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0U1"/>
    <dbReference type="STRING" id="76193.A0A194R0U1"/>
    <dbReference type="InParanoid" id="A0A194R0U1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="198" mass="22147" checksum="113C0CC2C2154A4C" modified="2016-10-05" version="1">MWVVVNTNYAILQAVYGFFNPPPLKSLKTETALIIGSGRGVGRQIAIQLSELGAVVLCVDKNVTNNEDTVKLIRSRGGKAYIYECDIIRKENFAVQGLAESLMEHLRINKTDGVYVTLTHIYPFIVDENSDLRLRISSYFGTITPEKAAKSILDSVRRNYPEASVPKHLLYLGHILRILPRKATVLIRDLLDTGVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0X5</accession>
    <name>A0A194R0X5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacylase-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0X5"/>
    <dbReference type="STRING" id="76193.A0A194R0X5"/>
    <dbReference type="InParanoid" id="A0A194R0X5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="13518" checksum="7FB47EDFA799A4B7" modified="2016-10-05" version="1">MKCEQYACRPEVRLLQDYVGINTSPGRNLRSAVDLLKRLGDTQNIKVTVYEAKPNYPVVIFKWPGLDPKLRSILLLSHMDVVPACYEDGWTYPPFSGEINDQCEIVGRGTQDMKSITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R101</accession>
    <name>A0A194R101_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endocuticle structural glycoprotein SgAbd-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_15021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R101"/>
    <dbReference type="STRING" id="76193.A0A194R101"/>
    <dbReference type="InParanoid" id="A0A194R101"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="413" mass="45643" checksum="002F56A80F258215" modified="2016-10-05" version="1">MLISSVNKDVHGWTNFNETKSRNLRDTESLLSVTCEHKSNAPACVGDYQGTRPVASLKMIFLLTSLLFYTPANSQVVPNRPVTQAPGVVNVSPTSMNPGFNRNPWQTGYNPYYSSPGAAVPIVSYTDNRGIDGSYSYSYASADGKEVQETGFVKDAYIDNAGNPQGTQVKEGGFAYTSPEGIPIKVNYVADEYGFRPAGIKIPADGSVVPSLMNGTKDAIPFYNKYSPFNNRYNNNYGPYNNYRPYDPRYPNAPGNYPVYNPYRQVALLVIMGTVSADVGIIQPFPPQPVYQQQQLYTTEPIPIIRQEHVQNPDGSYKWSYETGNGISAEELGYIKNLGVPEQEAQTAQGQYQYTAPDGQVIQLKYIADENGFQPQGAHIPTPPPIPQDIQKALDYLATLPPQNPDTRNFGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1S8</accession>
    <name>A0A194R1S8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 11"/>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1S8"/>
    <dbReference type="STRING" id="76193.A0A194R1S8"/>
    <dbReference type="KEGG" id="pmac:106716697"/>
    <dbReference type="InParanoid" id="A0A194R1S8"/>
    <dbReference type="OMA" id="CISNGEA"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="228" mass="25450" checksum="01A772F812B324D0" modified="2016-10-05" version="1">MSAALAMESNPETMNKYLKRLGVSDKWRMVDVISLDEDALHWVPRPVLALTLLFPLSKTYEDLRNKQEEDLLSKGHQAPKDVFHLRQVLSNVCGTIALVHSVANNTNQIELEEGILKTYLKNAKGLDAAAKGALLENSAAMMEAYKDIVAASSNEEVTAPDTVNHHFVTFVHKDGTLYELDGRKSFPIEHGSTNEDRFLEDAAKIVRSFIAREPDNICFNVMALVPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2V7</accession>
    <name>A0A194R2V7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2V7"/>
    <dbReference type="FunCoup" id="A0A194R2V7">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2V7"/>
    <dbReference type="KEGG" id="pmac:106714109"/>
    <dbReference type="InParanoid" id="A0A194R2V7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264873" evidence="12">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="52"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="29851" checksum="59942610A9615B25" modified="2016-10-05" version="1">MKLSLVALSCLLLAAANAYEPIELNYHENVGIPKAEAIRQAELAADFDGSRIVGGSTVSNLGEWPFLAGLVITLTTGQTSVCGSSLLSATKLVTAAHCWRTGNAQARQFTVVLGSLRLFSGGTRVNTNRVEMHSSYNMNSLANDIAMITINRVNLNNNINTIALASGNNNYAGTWARAAGFGLTRDGGSISNNQALSHARVQVITNDVCRRTFGNTIQSSTLCISGANGISTCSGDSGGPLTTDNRNTLIGVTSFGSARGCQRNLPAGFARVSSFNSWIRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3J8</accession>
    <name>A0A194R3J8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3J8"/>
    <dbReference type="InParanoid" id="A0A194R3J8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="365" mass="39541" checksum="E68289BCA0CFB1E7" modified="2016-10-05" version="1">MSGYLEVKYPFKSNLGLNPFKSWKKQWCILRPSATCGGGSLAVYCSEAGAPAGTVDLPSGCIVKRAKSRTRPHAFAVFSVEEPCKPRVLLAATSHHDAQHWMDKIRNLLNTENLIDEGPVKDSFSVTVLSTELSKKCGLSGADCSVTVGAAGLLVAKPRRLATLLPWPHLAELRPDPDDKNICVLTLDSGFSQGSGVMKLSSPLAGELAAAVRSALRRRALPRAAKLSRSEGDLRSRREVEAEEARRSSWYSGPSEVSLDDTDLIMCKESRPFPAGSLSLRARALLHLAPYEHTDSNYDRRSLVSVASGVYEEIAEEPGGGGGAARAMAARRALDCEEPTYESVAECLYATVCQAQPERRRPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R408</accession>
    <name>A0A194R408_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R408"/>
    <dbReference type="FunCoup" id="A0A194R408">
        <property type="interactions" value="2536"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R408"/>
    <dbReference type="InParanoid" id="A0A194R408"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="841" mass="95124" checksum="3EEAB8E311972F76" modified="2016-10-05" version="1">MADDDFSKLLQQAEQLTTEIEGNEELPRVERSLGQVLEASHELYSRVIQSGANDIQAHLLFGSKGIDLQQISQKLETLSSKRTFEPLQPIADSDVESFLKNERENAILSLIDEVNKNSLQTTEDQKWEHMLSEWNKEKTNLMNAMIGPSQNWLDLKKTPEPPSIADAPKKFGHSMLDSIEAAYARQIQQYNKLIFQGSKPRTALHQKFAQVAEKLNETKVREMWEIIKIMTNIPAIVRDEDPLKARGNPAIQQCLIAQGKKYLEKRYKQYMSDVVRANPAAAMRGGEPGTYPLVRGFVGLRLQGQGSQGLADGVVDDRPLWPMIYYCLRSGDANAALHCLRKAGRDHEEFISALEEHIRNPERALSDKLQTAINFQYRIQVRNSTDPYKRAVYCVIGCCDVSDEHSEVARTADDYLWLKLSIIKSRPNNEPVAFTYSDLQKLILEEYGETHYHAYEKPLVYFQVLMLTGQFEPALEFLSRIPRYQVHGVHMALALHDVYMLGTPRNVQAPLLSVDTDDPNPLRRLNLARLLLLYVRKFELSDPSDALHYYFFLRNLKDPSGKNLFMCCCTDLALESRDYELLFGKMDPVTGLCSPGLLDEFNNPHIDSKVIALNVAEQLVNKGLFEDAITVIALNVAEQLVNKGLFEDAITVYDIAGNIEKVLELFCVLLAQVVNSGGGAGGLRERLSLLADHVSQRLRYADTTALPAALLEAYVKLCKLMTFFDQFHSDNFEGALETLRECELVPLNAGELESRVSAARSARGELLRSLPAVLRALCHILLAQRQRLRNAHAHNIPMHTNKQVEWLREQAEVLNTFAGNIAYRMPGDTYSQLAQMQILMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R471</accession>
    <name>A0A194R471_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf-GAP with dual PH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R471"/>
    <dbReference type="STRING" id="76193.A0A194R471"/>
    <dbReference type="InParanoid" id="A0A194R471"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="97"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="201"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="354"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="487" mass="56729" checksum="6C30C48BFF647F84" modified="2016-10-05" version="1">MVGARRVVGSLYRECFGRQVEVEVSLAPSPVRSRDRSSRSKRAFDFRAATYASSVKTSADRELGPFESLIHNNNHPPRQSSGSINMTFNVWKHLTTAIKNPDWASYNLGIFICMRCASIHRSMGAHISKVKHLELDRWEDSQVQRMKEVGNTAAKNKYEERVPPCYRRPTKNDPQVLIEQWIRAKYEREEFCHPERQNYLSGYMEGFLMKRGKEDSRYQRRKFVLNENEDTLKYHHPCEDCGRATSCIGRFFDRLHLKNFARWRYHVKENKEPKGVLRLSELNVAFAPAKIGHMNSMQLTFMKDGSTRHIYVYHEDPEVINYWYMAIRCAKLHLLQVAFPSTPQSDLVLRLPKDFAREGWLWKTGPRSSDVHRRRWFTLDNRKLMYHDEPLDAYPKGEIFIGHESNGYCIKVSNTGNGCKEARFPFHVVTPERTYSLAATTHEDRACWLAVIQQTIKRPLTPQDSTIEATLVRKRTSSNSISIFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5X2</accession>
    <name>A0A194R5X2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264945" evidence="3">
        <location>
            <begin position="25"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="446" mass="50972" checksum="9CF264FDD12CDA6B" modified="2016-10-05" version="1">MNISDGAMLKAAVAALACLSVARASPSEPHQMRLYAQNSYNTQDLNSVLTSIEERLRLLDTINTAQVKQARRLDVIQDKLDRVETTLTLRLERAQLAAERLEHRLHMLQTTVQASIKESSEKIERSQIKIAEIAQNLTNHINSHAHLLEKVSGAYAETWHRGIVLEALMRDGLALVNVTRRELADGLRALARRQRDARLSSADLEAAFSRRLHDNSYRIDLKMQELLDEQKRFVDSCQRVQLDDPTHVADVLDKLIDSLINKTAATFHELQNIQVTMRNHDNKIMKLLNNGRQTQIQDSNCRRLETLFRNATHSTMKENELQQLTEKFVGLTNRADAALQRLERQLGFDNNEPTPPTSEVKEEADRLLLHLNAIRNEEISDEDDWEDSDQFNNLFDAGGGNDMMNEDKIILKNPLETSIAARRPHRRHLRKDPYDRGPSLKPKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R679</accession>
    <name>A0A194R679_PAPMA</name>
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        <submittedName>
            <fullName evidence="6">Endocuticle structural glycoprotein SgAbd-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R679"/>
    <dbReference type="STRING" id="76193.A0A194R679"/>
    <dbReference type="InParanoid" id="A0A194R679"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264946" evidence="5">
        <location>
            <begin position="19"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
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            <end position="304"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="593" mass="61265" checksum="E75F5C0F163A7F47" modified="2016-10-05" version="1">MIFKIVLLSLVASSYVLAAPTAVVPLEKQQPTVIPIISQSEELDPNGTYKFSYETGNGIKREEVSYDKIIPKAAGRKASSSEEGGESDESGDSDEIHVQRGSYSYTAPDGTIITLSYIADENGFQPIGSHLPRAPTPVPISSASNEKTGRALKTPDNSESASVQSRSGKASEDKLNSPESVSTASSPQQQKQPKDSEKSGDNPVVSDSASLATQQLELQPKPAETTVSSEPEQKIETTENAAAPQAETKSGSNEASTPSQSNDKATATETRSQPVSEPMSEKSDENLKTGASTGQSDSLETVETTPEAVAPKSDMTENQATTAAQSNEKSSVTEAISETTPEAISTQSEEQLAVSTTVLNEPENNDATTETTVSESGSESETIDATDSPQSSEKSDVTEAAPVTATAVAESAQTDSQPLEASTTSQSNTEERAASTETSTGSEAELTSGTTEASDQTVPQADVTEDGSGAEPKTNEYNSQTEETLLESSTQASSNEQTTVSSESVETTSGSSDEKTTEPSSGKTTIAVAVASDTTVKAESSVVPTKVTAVDEATTANADVTTIAAADTAQVVSEPAANAAPTSQEVSASASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R682</accession>
    <name>A0A194R682_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="76193.A0A194R682"/>
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    <dbReference type="Proteomes" id="UP000053240">
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    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20338">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
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        <property type="entry name" value="IBR_dom"/>
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        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="41712" checksum="EA5F68397DBBF019" modified="2016-10-05" version="1">MVRLAWCSHRCCESCLRQYLAIEISEARMPVNCPVCHENMHPQDVRRIVDNQTLYDKYEEFSVRRALAADPDTRWCPAPDCSFAVVATGCASCPKLTCQAPGCGASFCYHCKAAWHPTQTCDAARRSRHPPPRQPAPQQADMEHGEVKPCPRCSVLIVKVEDGSCNHMVCCVCGAEFCWLCMKEVSDLHYLSPSGCTFWGKKPWSRKKKLLWQLGTLAGAPLGIAVVAGRCRCVAPGAAPPPRRRSPTRRSATSHPTRTPPPDDSSPASVGDASLSAGSQQAEARAPSLAALAGSLGGHEAHSPSPAAHRLEVTADVAAADTASAASAASWPDDLPSTSSRSARLRSLFLYGAPAPPAPPDLEAGTCAPPPAPHDPPTAPHTPPAALLATDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6U6</accession>
    <name>A0A194R6U6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transforming growth factor-beta-induced protein ig-h3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6U6"/>
    <dbReference type="FunCoup" id="A0A194R6U6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6U6"/>
    <dbReference type="InParanoid" id="A0A194R6U6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="761"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="914"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116753" checksum="D8A71B8CAD263045" modified="2016-10-05" version="1">MSLLVCISRSSERARAERMHFRIENDFERSRQPQADHPGFNEHQTRFGINSPLQNFQQQPLLTSPPPQTIQFQKSIFQQPQHQQSQQHNPLSQNQQAYVQQFGNIVPSQGIPSNIPIGNTHSLQFGQSPNGNPNLNNFQQQNLRQISQQNILPQSIPTLASFQSGLPLGQNVPVFNTNPNIQGNGLNIAQQRPTQPAFLPTPSSSPNQPIFGQPNPITIQTAPNLAPQNFNFENSQLPFQSQLNQAPLFSNGQTTSQLQNYYEQQSKENLEKLKELQERQRIIQKHQEFVEKQQQKEQQKVEKLHEEFLTKQATKTVPTLATTESYDNFFNQNQERHRPLLPHETDLFRKALELYEKEHPTTTTSTTTTSTTTTTTARPPPRYRSRTTSRPRSPPQDRNKQKLYNEIKNLLEESETKGFDENLRAKSVELLQKPDILKQLKVALAENPEDFNEKNFTSREISLNGQKFEVIRTSNPNLIPRGAITADSSNIAKTIAATQDTETQNPISFDDLTKGVLPPGANYELIKQSDNGKLEEVSNIQNSIQGKKKVTFVFLEEQDDGSYKVKGVKANGQQTEEGPEVESIINKIKKGEIQLPGPTKISNAAFTSTTTPPPIPTTEYTEEPSRSPSSYSSFITTSNYGTSGHTNPVVHTTQAPVTYRDTEAPIRTTQHTTQSYPSLPPRTTTERFPVRSSTPRYILNRSNNQDLTPRASFSSSTIINTTPAYRTTTDPLVVIGSSATPPTVEEAKSFPTYNTNPSNINPGLVEILKENGLFATAKYLRQSGLDTILNETGPYTIFAPTDKAFRTLLVQLGGPDRAEEKFRDNPRLLSGLLLHHVIPGAFDIASLQDEMTGVSLAGTQLRVNQYDMHDVEWNEVRVTTINGARVLDDKKDINIPQGIAHAVDRVMFPLPVGDLVQTLQADRDRRFTIFLKAVQASGFADTLSESKTYTVFAPTDTAFGRLTPSELSRFAEKGAARALVARHVLPGTLYSAGMRYYQLRNSMEDAKPLTLQKNSGRIKVNNAQVITHNIPATNGVIHAIDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7B4</accession>
    <name>A0A194R7B4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DnaJ-like subfamily A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_08067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7B4"/>
    <dbReference type="FunCoup" id="A0A194R7B4">
        <property type="interactions" value="1425"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7B4"/>
    <dbReference type="KEGG" id="pmac:106714373"/>
    <dbReference type="InParanoid" id="A0A194R7B4"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000016">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily A, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="12">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="404" mass="44738" checksum="8922051BCFE945B8" modified="2016-10-05" version="1">MADSKLYDILGVSRNASESEIKRNYHKLAKEFHPDKNPAAGDRFKEISFAYEVLSDPAKRKTYDKFGLKGLQEGGQGGGLSTDDLLGHIFGDMFGMGGGSRGRGRARGEDTIHPLKVTLEDMYVGKTAKLQLSKNVICGPCKGVGGKPGAVVSCRDCHGQGIKVTYQQIAPNMTRQYQSRCPTCLGHGETISDKDKCPKCKGKKVLNEIKILEVHVEKGMKEGQKIFFRGEGDQQPDVQPGDVIIILQQKPHDVFQRTGDDLIMKHDITLTEALCGFQFVVQHLDGRELLIRHPPGVVIKPGDLKGIQGEGMPQYKNPFEKGNLYVKFNIVFPENNFGTEEQLQKIESILPPRPAFVMPTGEDVEEVNMMEYTASERSRGREEAYASDDEETMHGGPGMQCAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R872</accession>
    <name>A0A194R872_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_06431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R872"/>
    <dbReference type="FunCoup" id="A0A194R872">
        <property type="interactions" value="1917"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R872"/>
    <dbReference type="KEGG" id="pmac:106714076"/>
    <dbReference type="InParanoid" id="A0A194R872"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000992">
        <property type="term" value="F:RNA polymerase III cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="34492" checksum="348F4759A770768C" modified="2016-10-05" version="1">MDQMLPSPYNIPGIDTPLHQPEEDQQILPNAMQQQQQIQQQQQQQQQHSLASLGSSPLVGFGASLLGTPQRSMHTYAPTASYATPQQMMQPQTPQNMMSPLITSGSLVGQQILGQASPAPMTPMTPHSADPGILPQLQNIVSTVNLNCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEDSRLAARKYARIIQKLGFTAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHGQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYEAFDNIYPILKSFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAM0</accession>
    <name>A0A194RAM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Four and a half LIM domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAM0"/>
    <dbReference type="STRING" id="76193.A0A194RAM0"/>
    <dbReference type="InParanoid" id="A0A194RAM0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09417">
        <property type="entry name" value="LIM2_LIMPETin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09421">
        <property type="entry name" value="LIM3_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000081">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25076">
        <property type="entry name" value="LIM_FHL2-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21757" checksum="3733FE251B5CC693" modified="2016-10-05" version="1">MADVDVQVQYTTTERKTRKVKKTSKRRESKDGEVTVTELEQTNTTNTNDDGGEYTKAMNKDWHSGHFCCWQCDESLTGQRYVLRDDHPYCIKCYESVFANGCEECNKIIGIDSKDLSYKDKHWHEACFLCAKCRVSLVDKQFGSKLEKIYCGNCYDAQFASRCDGCGEVFRAGEYLSLRKQTIVVLSGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBL6</accession>
    <name>A0A194RBL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBL6"/>
    <dbReference type="InParanoid" id="A0A194RBL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="77" mass="8481" checksum="70D195686C650C0F" modified="2016-10-05" version="1">MRLVIIGRILVYVSESAESARARRCAAAARLLAAESRALRYLDDVVALLNGNVAAARRAQAWPFALGRREPARNYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBV1</accession>
    <name>A0A194RBV1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBV1"/>
    <dbReference type="InParanoid" id="A0A194RBV1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="181" mass="20701" checksum="7B23C74E2F26E652" modified="2016-10-05" version="1">MFICFSKKLLPPLVRLVRKIQLNAESDLELEGLIPEESDANMDLLSIEQDQNQIIDEKQNYWKPEDLAIEESSDSSETSSSIVTNLSMEKMQKFDKEIETSDSSEDEYMPQIKQPLKEEYRSTAVVEPANTWSNAAYNVFQNIGGAVVNMIYTSQDERRRTRVSSIDSSDGFEMIDKNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCI0</accession>
    <name>A0A194RCI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Survival of motor neuron-related-splicing factor 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Survival motor neuron domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Tudor domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_09334</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in spliceosome assembly.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMN family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCI0"/>
    <dbReference type="FunCoup" id="A0A194RCI0">
        <property type="interactions" value="1568"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCI0"/>
    <dbReference type="InParanoid" id="A0A194RCI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1046"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="21">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="22">
        <location>
            <begin position="687"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="330"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="745"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="368"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="447"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ15307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121008" checksum="59E5600F9B0433A9" modified="2016-10-05" version="1">MSLMESLKELGWHLTQEGIDTISENGEIQDVNIISRKALDYDLREIGEGAFPEDFTKDPTKLEKPIVVQIQKIRNVSAPKANEESCSAPRMLKLTLHDGKTICTGLETSHISSLSINTPPGTKLLLNNEGLEVCHGIIWLSPSVITILGGKVAHMIEKWELNRSLAKHTRGGIGAEGGPPPWIPFGQRLEALTLDKQFKSLQEANKQDNAEFEAQRKGAIAEAQRLSGVKKVFGGGTKPLLDANVQKIVDAGFSEEQAENALKYTKNNVDRALRILQKRDNSENRSKDKDKKETEPPKRKPRHREQTDDDIVPVKPSGMVSLFDFLEDKLPNIPDKDKNNQKNNSSDDRGDRNYTKERNSAKSNSRSHRYDGPNRHKSEGRGHYSNDNHHRDDRKYQNQNEKPPRFQKKLDERNKHQQHQHHHQSHHQQQHHQQQQQQQQQHHHHQQQQQHQQQPHHQQQQQQKQQQQQQQQQQQLHQQHQHQQQQDVNVNLNLQYNNSYPNPNNPYDHSRFNDRNMNDNKIQLSQNFRNNSNVMDSLTEATANLNILSNPSRPSEDMPRNYPTHPDQMYLKQQFMPNQNMQDMTAYRRANDMQKYPDQQYQRRQHQQSNGYMEPQQNLQNPMYANMNYMGGAQSGYNGRQYGYGGRPQEYNTMRPAGPFLPGSLLGFQNAAVNEQARAMLGVTDINWKVGDRCLALYWEDNNFYEAEVTGISANTVVVKFCAYGNHEEVAVAGTYLGAACSPLAGRRGTPRRSGRASPPPPPPPPPPPPPQADRALAHTHCTEVAVAGTYLGAACSPRAGRRGTPRRSGRASPPPPPPHPPPPPPPADRAPAHTYCTECAGMGIGAMDSCGRCMKVSLIAINILIFISGGVALGVGTWVWVSRSFSTTLMSNNMFIASVGVVLVSGAAMMLLAVLGCCGAAKEVKCMLLTYYILMFIIFVVALVGGILQFVFREKVHSTLDREMFAAIPYYGVKHEYTRAWDDTQTFLQCCGVRSHNDWNDNVPDSCCKEVYPGKRLDCKSSPNPTTMYTDGCLEKTISFLRENAVSVGVTAIVTTIVMLLALIFSCALFVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD44</accession>
    <name>A0A194RD44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptor Mth2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD44"/>
    <dbReference type="STRING" id="76193.A0A194RD44"/>
    <dbReference type="InParanoid" id="A0A194RD44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="29325" checksum="D792174586461036" modified="2016-10-05" version="1">MAAFGWLNVMCFDIWWTFGSVRTVQPLRKSSSERRRFIWYSMYAWSIAVVLTLTMFLLDRYPISIILDANIGNGACWFGSLQNVQSDWPHYIYFVIPIGIITGTNFILWILTARHCARVKSEVHRLQAGSVGDRAKRRFRVDRAKYVLTGKLWVVMGAGWVSELLSTIVTQPPWLWTIVDLFNELQGVFIFLILVVKPKLYYLIRKRLGLEKPDSQKKGTSSSARTSSTFLSRTISSDERANLRTNQHNNHKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDX3</accession>
    <name>A0A194RDX3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein detached</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09409</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDX3"/>
    <dbReference type="STRING" id="76193.A0A194RDX3"/>
    <dbReference type="InParanoid" id="A0A194RDX3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008586">
        <property type="term" value="P:imaginal disc-derived wing vein morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007474">
        <property type="term" value="P:imaginal disc-derived wing vein specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000001">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="439"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="732"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="647"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="651"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ15480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="837" mass="94616" checksum="CC5DBAE9030819C9" modified="2016-10-05" version="1">MFLWMCKKCLCQWGLTRVRAFTTSLEELAARVQAAEAARASWRAPGDARDARAQLDAVSRARAQLPPLRRLADELRAQAQHLARDNVQLPDHLRARLDDLNARVTALSAGGEERARQLAGVARDGGAGAAQGFLAGSVRPPWERAVTPANVPYYINHELETTHWDHPKMIELMTSLADLNEVRFSAYRTALKLRAVQKALCMHMLQLGGALDAFDAHGLRAQNDRLIDIPDMITVLTSLYEVIAAENPSLVNVPLCLDLSVNWLLNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLIADPSCRADQRKLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCFEQASAGGREGGREGGKAATLDRKTVGEKDKEKEKEREKEKEDKEKSVERDAEGQLQHIEAFHFLQWLQKEPQSMVWLPVLHRLAAAEAARHQAKCNICKDYPIVGFRYRCLKCFNFDMCQKCFFSGRKAKNHKLTHPMQEYCTAVMHMLQLGGALDAFDAHGLRAQNDRLIDIPDMITVLTSLYEVIAAENPSLVNVPLCLDLSVNWLLNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLIADPSCRADQRKLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCFEQASAGGREGGREGGKAATLDRKTVGEKDKEKEKEREKEKEDKEKSVERDAEGQLQHIEAFHFLQWLQKEPQSMVWLPVLHRLAAAEAARHQAKCNICKDYPIVGFRYRCLKCFNFDMCQKCFFSGRKAKNHKLTHPMQEYCTATTSGEDVRDFTRALRNKFKSARYFKKHPRVGYLPVQTVLEGTHCRHTHNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE97</accession>
    <name>A0A194RE97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-aspartate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE97"/>
    <dbReference type="FunCoup" id="A0A194RE97">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RE97"/>
    <dbReference type="KEGG" id="pmac:106711732"/>
    <dbReference type="InParanoid" id="A0A194RE97"/>
    <dbReference type="OMA" id="PGMREPK"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF17">
        <property type="entry name" value="RE49860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="37430" checksum="98FB63220BB130B6" modified="2016-10-05" version="1">MTDGPNIAVLGAGVVGMTVAKLLQDENRKFNITIIADSFKENTTSAVAAGIFRPGTSFCGPTAEITKKWINNSWYYWQDILKSSEAPQAGLMSFSSYIFSKERYTVTRNHLIEDLVPIYRAVDKNELKICGEGWKYGSYFSTIKIGCERYLPWVERQFLDKGGKIITSTVESFTSLPEKYDLVFNCTGLGAKLLCNDHHLVPIRGQVIKVKAPWLKTAIYGDYDTYIIPGFDGIATLGGVRQYDSYNMKICKYDSAAILERCCEMLPALKKAEIVAHKVGLRPHRVPVRVEPETVNGVKVVHCYGHGGYGVTCAPGTAMDAVRMGLDLLKTNVKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REP0</accession>
    <name>A0A194REP0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REP0"/>
    <dbReference type="InParanoid" id="A0A194REP0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="19576" checksum="D7EFF06971A53F87" modified="2016-10-05" version="1">MSGSGLTQTDDVDERKTNYKETETIIIVSVFGGAWLLLLLLVVVLFVQVASLRKRLADMQTTGRLRVQKLKMNPDKNYAFNNPSLVPDEELSRRGYSMYVGAEDDVESGRPAERQTGGQFVEELTRELDHRQQRRANAPPFLLHSIEDSKNRAFSNPVASRGKQSDTNPNFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF91</accession>
    <name>A0A194RF91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF91"/>
    <dbReference type="FunCoup" id="A0A194RF91">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF91"/>
    <dbReference type="InParanoid" id="A0A194RF91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265155" evidence="3">
        <location>
            <begin position="18"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="767" mass="85380" checksum="27A2A5EDC100AF73" modified="2016-10-05" version="1">MLLKLFIVLSIVSRTYLTSTDEEVIVETVNSDEENIVDNVNNENIVPIDVIRTLPRNNNYEIPVISTHFNRREERSQFNNPIIELIANVIGTQSGSKPTDFFAFLQDQYPLPGEYKSDMNNENIVPIDVLTLPRNNNYEIPVINTHFNRREERSQFNNPIIDLIANVIGTQSGSKPTDFFAFLQDQYPLPGGLQSPLPQYDFVIVGAGSAGCTLASRLTENRNVTVLLIETGKPEMLLTDVPAIAPYFQATPYVWHYYMEPQPGVCLGMENGRCFWPRGNAVGGSSVINYMIYTRGRPEEWDRIAAAGNYGWSHNEVLEYYKKSERAKLDGYEKNPYRNRDGVLPVEFVPIKTKLLKAFLEAGRILGHPTVDYNAPEKIGFGKVQVTMSMGRRFSAAKTFLHTHKKRPNLHILPETRATKILIDPQTKTAYGVEYVRNNVLHRVTVRKEVILSAGPIASPQLLMLSGVGSKDHLKSVGINVIKDLPVGKSLYDHICFPGLIFTVNQTNISFLESQASDVNTVVQWLKNGDSAVSSPGGVEGIGYIKTPISDDPELVPDIELISIGGSIVSDGGPGGSKAVRKGMRITDNVFNNAFGPIDNTNTWSAFPMLLKPKSVGYLELKDSNPFSHPKMYGNYLTDPRDVATFIAAIRHVQELTATEPFQKYGTKLYPANYPTCSSLQFDSDEYWECAVRTLTATLHHQIATTRMGPQSDPLAVVDPELRVHGLKRLRVVDTGIIPVPISAHTNAPGIMIGEKAADMIKQTWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGT7</accession>
    <name>A0A194RGT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome-releasing factor 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGT7"/>
    <dbReference type="FunCoup" id="A0A194RGT7">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGT7"/>
    <dbReference type="InParanoid" id="A0A194RGT7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="740" mass="82403" checksum="03478C3CD1D5A0FF" modified="2016-10-05" version="1">MRSYCIFNYYKKFFKNVPTRKYSSNFEYETKIEKIRNIGILAHIDAGKTTTTERMLYYSGTIRSMGEVHHGNTVTDYMEQERQRGITITSAAVSFPWHGTQINLIDTPGHIDFTMEVEQSLAVLDGAVIVLDASAGVEAQTLTVWRQASGYRVPRILYLNKMDRSDADVNSCIRSVREKLQATPLMIHAPVTKEGKLIGLIDLVTCEEVIWTQGRGQNYVRRKLAEKQDGKNWEKIMNSHRQLIDTLSSLDDQLADIIIQQDSLDNIEIPQINDAIRRCTLKMSGFPILCGSSYKNIGVQTLMDSIVSYLPSPLECNRIYKSFGSELAARAFKVQHDDQRGVLTFLRLYSGEIEKGQKIYNLAREKSEQTGSLYVALADEYRPVDKVTAGNIAVVSSLKTTMTGDLVTSTHTSAKRARSQLARWLQESGAEDLMLPSALQRLKTLDTQPSTEELAEVLLGIGTTVPEPVFLCSIEPPSAAYQSALETALAELQREDPSLRVSTDDETGQLVLAGMGELHLEIIKERIIREYKIDVELGELQIAYREQLLGEAKSTLDVDRKIGSVRQVVKVTMSAKTVKGISQDKILKLDKSGESAANLSHVHPRTLSALQQGVRAALQHGPKLGCPYTNPLGHMPHLLHPCAKREHYCQRVSPSRIACKRSAAATAQAFCPLLLAACALPESLSRRRLLAASPGCLRRAPGRHRHNHRLHRPLCDHIIAIHYRKMLSGGKTGLCGGLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGX0</accession>
    <name>A0A194RGX0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Juvenile hormone esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGX0"/>
    <dbReference type="InParanoid" id="A0A194RGX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265174" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="32"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="579"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120219" checksum="6136EB53168E67AB" modified="2016-10-05" version="1">MRAYNVYRLAVAVFLHVGAVIAEPVGCEVRARLESGWVCGLRRWAENNTVYASFRGVPYAKQPLGELRFKELQPAEPWDYLDASEEGPICPQQDVFYGKMMTSHKMEEACIYANIHVPIEALPQSSLRRPLRHLKPPYEAGLSEEDDPQQPGLPILVFVHGGGFAFGSGNSDVYGPEYLVSKGVIVITFNYRLNVFGFLSLNTPSIPGNNALRDVITLLRWVRANARSFGGDPEQVTLGGQSAGAAIAHLVSFAPDTDGLFNRLILMSGTAMPAFYTLSPAFAQNIANMFLTHLNITTTDPELAHSQLIKLPLDKIMNANSMLIDYFGLTTFVPVLEKKLPGVNPVILEDPITLMNKGVGRNMEMFIGFTSAECESFRPRFEQIDMVTRINENPLLVLSPNIIFNAPASDLLNIAKEVEQKYFNGEPTMDNYIHSCSDTFYNYPAMKIAQMKQAMGGAPVFLYQFSYEGKANVIKTAFGINYKGVGHVEDMTYVFKVNSIMEKYITFPSGSKDDLMRKRMTAFVSNFVKCGYPNCIGNEVAAWRPVDRYLRYQEIENTYYKSTDPTDAQIEILISMTHQNVITTAQGLLRGVSKDGYISYIGIPYASSNGTGRFKRAGIAPFWSGIREANDPHCTASSSVDKCLQLDVYIPTTPNEQPWPVLVWVKGGNGFYHPGQLVRRGIILVTVRHRMGPLGFLCTNEEQIPGNAGVKDVVLALRWVKDNIVAFSGNPDNVVLAGESFGAAIVETIMLSRMSQGLFHGAVMQSGTVLSPWAFNYDPKSRVKALMTAYDSKEFPETLLETSAEDLVEKSKDLDMPYFPFGICVEKSFKKEERLLDELPYDLLSDGKVIDVPLIIGYNNNEGYIFANMLKIANVIRRITTDMTFLLPMELEDMGARELNHTRDRIKNIYFKNGNFSLASVIEYHSDAYFINHIHRSARLHSSSSHYPVYYYQFSYSGDIGVEPENGIDKVGAAHSDELAFLFSENGRTLSGDDGKVQDKLVTLWTNFVKHLNPTPDKSDSTRWESLDYQTPRLLNIGMDMEMMDYPRTAAMDMWDEVYEKYYTRERNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH62</accession>
    <name>A0A194RH62_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_14019</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH62"/>
    <dbReference type="FunCoup" id="A0A194RH62">
        <property type="interactions" value="1613"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH62"/>
    <dbReference type="KEGG" id="pmac:106708662"/>
    <dbReference type="InParanoid" id="A0A194RH62"/>
    <dbReference type="OrthoDB" id="624114at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="22">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="436"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ17163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="694" mass="79549" checksum="38971AE6FCEB3DD1" modified="2016-10-05" version="1">MTSQCYEKEPLKPSSKVEAAVETIKKGIEEKEKLPKKEEVKKKSLKQRIMDEITHYYHGFRLLFIEIRISTSLLFQILKGKSLTRREHRLMVTTVGDLFRMVPFIVFIIVPFLEFALPLFIKFFPNMLPSTFESRSQKEAKLKQHLKVKLEMAKFFQETLDQMAPQASNRHSELAKEFSNFFNRIRTSGDVATSEEIMKFSKLFEDEITLDSLQRPHLVALCKVLNVSTIGTSAMLRFNLKMKLRSLAADDKMIAKEGVDSLNFSELQQACRARGMRAYGVSEERLRKELRNWLDLSLNEKVPPSLLLLSRALMVPEHVPTTYKLKATISALPEQVVTQTKAAIGEKEGKVDFKAKAEAIKLEEQKIKEDMKEFLEAEREKQLLEAKKKQKEDLVDKAPIIELDTEQVMVDPAPVIAVDVPKQKEKSEEGLSGKDLEVIEDALEKLAEQKKSLLLEKESIQVLKTELLDYNEDVKEMNEIVKSKQADIKLTKGARRLYRAVNNMISKLDAALVELENKEKALKTTLEQTKTEPQKAKEQLIQIDELMHSIKSLQKVPDEAKLKLIQDVLGRLDDDFDGQLKIDDVLKMLEIIGNENVNLSEKQINELIELLDKEEILEIESKIQKALDKAASAAKEQDKSTESDGKSLFDIIREAQKRREMKKAVEKFGEQRAMPKSEDIVTKAEESSKRPEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHN5</accession>
    <name>A0A194RHN5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHN5"/>
    <dbReference type="InParanoid" id="A0A194RHN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="148"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="440" mass="48920" checksum="DE269E1E17C4783B" modified="2016-10-05" version="1">MSTATVFLFLLDNLPGFQNSLNLTLATLLDKEDLSLEFSLIHKCNPTVAQSVLNDIKNNVEEEKVSHENVSDIVKHDDFKEAFDELSPEALYNIGTVFDNTMEDSENIESYETKNYNKTSKIKSDYPKYYKDQEGDDFDIDNDIDSDIFESKVKLPDSVPSMVAMFETLSNVTAQTCGGTLLSPRWVITTATCLDLLSGNGSKSHNSSKSEYTIVTGANNPLKDGTIHHVTDMILFPKETLKTNASTIDNFDRTKRAGVHLGNVTLALLRITPPARIQTLTISHVPSKGEEDVQLYGWILVKEASGKEVMKATSLSAKTMRSEECGANLSDVYHESMLCLNPRRKTQKDIENKIKQASGPVLAARNNKPMLLAVAQFELPSPQAPLFAHPLSAHATWINAIAWVPLVKFTHDVTFEESVEGRRRSGHRAERGQSAQSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIS8</accession>
    <name>A0A194RIS8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIS8"/>
    <dbReference type="InParanoid" id="A0A194RIS8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13992" checksum="7FF3B3450ABA39C5" modified="2016-10-05" version="1">MSMGSGRFAISANSARMIEQAEDDTNKEPDYAKPLTLEVPILHMAIIDNRATNRFDTRAQHERGDAGDSINITDTLLSVASVNNDDFESIMKLARDDVTTEDIRSIETNNRYLWKVLEEDDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ46</accession>
    <name>A0A194RJ46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ46"/>
    <dbReference type="KEGG" id="pmac:106709880"/>
    <dbReference type="InParanoid" id="A0A194RJ46"/>
    <dbReference type="OrthoDB" id="8014143at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="19878" checksum="8AAB15A3407571DF" modified="2016-10-05" version="1">MGQEQSYVAHRGAQVRRYADKINDPVRSKSDSRSNCDEYKRYKTRRSPDSNSDSSNESSGYRSGSSAYDFRSDRSSKSEYYCTSLYKNDHYKDVNKELYKPVKITKEKRYKVQLFEVNDEEIKSARLKGYLTDAEKAKLKAGPTPKKAGIRNYTPKILSEDEQRLKIEGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJN5</accession>
    <name>A0A194RJN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJN5"/>
    <dbReference type="STRING" id="76193.A0A194RJN5"/>
    <dbReference type="InParanoid" id="A0A194RJN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF26">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="150"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="257"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="979" mass="110042" checksum="5DF160CADEBE4B63" modified="2016-10-05" version="1">MVSGALFKSVKSSLSLVQCAKTSVSRVRTFTSVLNDQQREIQELAKQFSDEQLKPNARKLDLEARFPFDQIKRLTDMGFMGMAVEEAYGGRELDYLSVAVAVEELSRGCASTGMIMSLHNFLYANLVNEKGTPQQKEIFLCDFTRGSIGCFALSEPDAGSDVASIKTTATFDGDHVILNGKKSWVSSAIEGSALIVFATVDPELRHKGLACFLVPMDAEGVFRGKKQPLMSVRAVTACDVTFEEVRIPKTYMVGQVGEGFKIAMEQLDQARIGIAAHAVGIAQAALDTAIDYAKEREAFGKKLTRLSSVKDRLTEMSIMTETARLLTYRAATQVSTKNSSMAKYVAGKNAIAVADHCVQILGGRGLATTHNAERHYSEIPDIDGTHLVFNILCSELDRIQNVADLDKIQWPENPNGLKISAAFEGLGLNTLGRLPPNAQVESLRFSNNAIKTYWPDPFNDVPNLKRLSFSQNELMEITPDLFTNIEHLEELDLSYNKLTDFNVLDFKFLHNLKRLNLQSNLIKKMPTEVLSPMILLEDLDLSKNGIYDLLLQKSESEPFKVVKRLSLSGNRIRSVTKESFPLNNSIELLDLSNNVIEIVEENAFLTCVNLRELNLGQNNITFTFALPPSLQIAILKINTLYHWPTFPGGITYIDLSYNRLSDMYNENQVEFDNLEILNIGGNQIKDINIENKLPKLYSLDISYNLIKEIPKCLNSQILPKLEELRLDGNPIEDIYFKNILSLKNLYLNDMHKLVIVKDKAFSNVIGRGDETTNERNCFYLYMSSCGSLSEIQEGAFDATSLCMIDISKNNLTRLSKDLLDWRSLNEGADLQYNPWECSCPLQWVLDDLLPILYKSNSRLLTELRCGSPRGYEGLRLVHWYNWTEPAMCSDMMMRAGPHGTYILQPSTDSGPKFNYLIIILVACITVALLIAIALFVYLMRNRRRHRLRQAALKRKRQTAADIKNSNGLQKEKFGSFNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJU9</accession>
    <name>A0A194RJU9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_08231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJU9"/>
    <dbReference type="FunCoup" id="A0A194RJU9">
        <property type="interactions" value="1306"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJU9"/>
    <dbReference type="KEGG" id="pmac:106709617"/>
    <dbReference type="InParanoid" id="A0A194RJU9"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000012">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="112"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="507"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="627" mass="72836" checksum="D89377D7FD658989" modified="2016-10-05" version="1">MITRRWFHPSLNGVDAEKLLMDVGQDGFFLARPSMSNKGDFTLSVRRGNEVTHIKIQNNGEFLDLYGGEKFATLSELVQHYMDNQGQLREKNGNIIRLKIPLNCADPTTERWYHGQLTAKEAERMMLENGKNGSFLVRESQRQPGDFVLSVRTRDRVTHVIIRRKNNKYDVGGGEQFDDLVSLIEHYRNYPMVETTGEVLRLIQPFNATRIQARHLQTRVKQLQKENEGPIESMAYKQGFWEEFETLQMMENLQLFDRMEGSKPENIRKNRYKNIIPFDHTRVILRDIPPDAPPGADYINANYIRCESTDSDSNGSFETHFSREAYSKHKDKTSPHHTSVIITEEKPKETIKSQENGIRKIIPSFVLRPNPNYVNTTIPKSGLATENGAAEHVYNKLYIATQGCLSTTIYQFWSMIWQEDVRIIIMTTKEIERGKVKCERYWPDLNKTEVFKKYTIFNESESSTPDYTLRRFIVTKKDESDKKRTIYHFHFTAWPDHGVPSEPGRVLNILLDVNHRLQQIMTGPDAPLQAVVCVHCSAGIGRTGTFIVIDMILDQVRKEGYDCEIDIHRTVQMVRDQRSGMVQNEAQYKFIYMAVLEFIETERQRFFTCPETKKDSPRLRSQPVPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK80</accession>
    <name>A0A194RK80_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nuclease HARBI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK80"/>
    <dbReference type="FunCoup" id="A0A194RK80">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RK80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="109"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="39886" checksum="D86DADD867EAACCB" modified="2016-10-05" version="1">MNSSEFEYLQNLIGAKIGKRDTTFRKSVSVTERLAVTLRFLATGSSYKSLGNVFKLSDQVISIIVPEVCEALNEVLKEYIQIPTTPQEWLHVANSFEEKWNFPNCLGSIDGKHVAIQKPIDSGSEYYNYKGFYSVVLLAIVDAEYNFLYVNIGCQGRISDGGVFANTKFRNKINDNSLKIPSDSSLPGRNKPLPYVFVTDDAFPLQKHLLKPFPGPQDSNSKERIFSYRLSRARRTVENAFGILSARFRVLRTTILLDPEKTTTLIMTCVLLHNFIRKTESSMIYAPSQYYDGDDIVTGTRIDGQWRLEQQQLTPLEACESLTDDGKEIRKEFAEYFSNEGFLDWASKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL77</accession>
    <name>A0A194RL77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RL77">
        <property type="interactions" value="1942"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL77"/>
    <dbReference type="KEGG" id="pmac:106709082"/>
    <dbReference type="InParanoid" id="A0A194RL77"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058540">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24546">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="694"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 third Ig-like" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1370" mass="153090" checksum="F147FECBAB6946BD" modified="2016-10-05" version="1">MAKSAQEFIQSSFSPIVAVLCSSKVNNLVSKNNLTFSELLQPFASMEWEGQFREPGGSICTVKNWKLIIRDVNWKPLQPTEARRQLNNAVLHNFDDKTSTFEFDGRKFDVPKLTPWFDAWRETYLEVQFPSDHEFTKHFLSCIIVATTLDDNIVDTYNQLNQQYAQLQNVAPPKLPKWFNNGVLKTYLLLHDVSTVSKEKADATFETVKQAFGASNCFMLTINSKSLSDPKLLTDYWAQYITRSTESYSEMSSPMNVTTFEPQAALPQTTIVTPEDKPNIMITSTQEGVHPLTATENDVYDNANSLQTYSFSGSSESVNVAGKGVDYSNEVHGAALNTNDIEAIKKFLHEYASKALLPYLEKQISHLSEVVANRKGVSRSLLSATKRWFATGKPGNTTGNNTVIYSSDCPELQLRRLGDLWFLCGQWQRAFDAYHTAKREFYADSAWLCYAGALEMAAISAFMAGEANRKTHSYMEESIVTYLNTCRMVQYAVRATLLSALCLINSGLHGEAAKQLIRMTSEDSDLRSAMLLEQASLCFLSGPGTKAMCRKYAFHMVLAGHRFSKAGQKKHAYRCYHQAYQVYTGSGWRLATDHVQFALGRLAGALKQAVAPRWLAAPLAPASPQPPPQQAAFLREYMLAHQQWIESSEEFGGKLPVVPVPLVVRGETRVSCAGPAPLAAAGRVAAAAPPATPHAARVWHRLEEMLIHAAQGAPPMIFKPTVDLYTEDTDANPIVPQGEPIQVTITLTNPLKIPLLLKDLELLWQFIPNAENTNVPKDILDNEPFVASGRTLDSNVISRQKIQVSLLEGECNKRLTFSLTPLQVGRLHIKGLAYKLTNTGEDGKENNNSIVITGKLELSSAGNDADKRLQIIVIPQAPCLQMTFSEISPDVISGELRTIDVEFRNVGPVEMKNLYVAVSHPDCLSLVTEEPSDDFSILYEEKYQEPPVYQDERAARAGRRASAARRHTRLVSSVLGAAAGVRARLLLRPRRRAPALRLLAYYETALPQRPHRLLRHEMRLQPMEAVEIQVTPRRSLNKSEEEMVENMSLAVEVKNVCKENNEEIAIEVLEVSMISQQWTLTDLIAAPNMDAALIPRERVHYVFKAKRIFEESDKSNVEYSHIKVSTKRSQEIEADVKSLPYSRFLMDCLPSIDDLTDSNYSETETKRDGLIQSMLVVRWKAHDKVKSRTAVGQHCLWINCFSKALSQEKEVSSELPIQLDDLENFNEPKDKSDTNNIVLFRLEHSNYVNHNFMQRKLCMIPIVINIVNCYGVPVSVFIDMTKQQNRESTSKLGWAGALSSGPDAESKSLGVNVTLQKFETRRVHVRALCAAPGTYVLGSAFTLTTRCGLGTQATAHFSNNTSLLVVRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM64</accession>
    <name>A0A194RM64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Congested-like trachea protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM64"/>
    <dbReference type="FunCoup" id="A0A194RM64">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM64"/>
    <dbReference type="KEGG" id="pmac:106721027"/>
    <dbReference type="InParanoid" id="A0A194RM64"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000051">
        <property type="entry name" value="Mitochondrial carnitine/acylcarnitine carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="298" mass="32343" checksum="5A95AB7B4492CCB1" modified="2016-10-05" version="1">MSEKSSPIKYFLSGGFGGVCTVLSGHPMDTIKVRLQTMPLPKPGETVLYKGTWDCFKKTVQLEGFRGLYKGMSAPLTGVAPIFAISFFGFGLGKKLIKSDEDQVLTKTELFAAGAFSGVFTTSIMAPGERIKCLLQIQQGANAPQKYKGMVDCARQLYAEGGIRSIYKGSVATILRDVPASGMYFMTYEWIKEVLVPEDASNKLKMVATIVAGGCAGIANWLVGMPADVLKSRLQTAPEGTYPNGMRDVFKQLMEREGPLALYKGVTPVMIRAFPANAACFVGFELAINFLDWVAPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM68</accession>
    <name>A0A194RM68_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc carboxypeptidase A 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_13932</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM68"/>
    <dbReference type="FunCoup" id="A0A194RM68">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM68"/>
    <dbReference type="KEGG" id="pmac:106708633"/>
    <dbReference type="InParanoid" id="A0A194RM68"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265304" evidence="16">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="121"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="53120" checksum="6820F81B5AD66AA8" modified="2016-10-05" version="1">MFLKIFTVLLIIVTFVNTSKVTFNGHRVYKVIPNNDNEKEVIINTQKQGIGELWLDQFDVRDGVRITVAPEKNQQFLDTMNKNDIEYKEVIADLQQVIDDQLKSASRSDRSTSFLSFDWDRYHTLDEIYNWLDQLQVNYPNIVTTVVMGRSVENREIKGIKINYNPNRNTTLIGMIEGTLHAREWIVPATATWIIKEFLTSTDPEMKALAKNIEWHIFPVVNPDGYVYTFTTHRMWRKNRSTRNFTSCASTGVDDDMSNGVDLNRNFDFAWMEVGASDNPCTNTFAGPFALSEPEARAVADYVLTLNNQGRLIYYFGLHSYTQLIVVPYSHITAEESAKLINYADMYEIAVRGAEKLKERFGTEYRVGVSADIMYPMSGTSFDWVKNVTDVPVSFLIELRDLGEYGFLLPASQIIPNNLEIMDALLEIDRTTRRLGYYYSGTNNLISSLTLIVFSIFVKLFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMF5</accession>
    <name>A0A194RMF5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRISC and BRCA1-A complex member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMF5"/>
    <dbReference type="STRING" id="76193.A0A194RMF5"/>
    <dbReference type="KEGG" id="pmac:106720687"/>
    <dbReference type="InParanoid" id="A0A194RMF5"/>
    <dbReference type="OMA" id="RPQHQWP"/>
    <dbReference type="OrthoDB" id="547311at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="32487" checksum="DA38FFFD43E22D2E" modified="2016-10-05" version="1">MDSPDILPSCSNSNVTDSNDAGNVRPHKSREDFAELRDQTIENFQKPNLPNVNVPEKIIICLDLCYDNENSLYRLGDGTTFTPVKMLKRVLEFFIHSKHAINKQTKFALVMLKEEPCWLQGFTNNPKDILSVVDYLSPEESTSETFDFQKLFQILKHEIQVPEYSQGDCILPPPYVVRMIVLYGRSNCVPQIPQDDPYFIHLKKQFYFYIDILLAHEEDCGMYKCEEVYDALQDLDNGYSYVYEVSRNATKIHDCIAKLLAHPLQRPLQKNTDYSFGCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMS7</accession>
    <name>A0A194RMS7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon regulatory factor 2-binding protein 2-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMS7"/>
    <dbReference type="STRING" id="76193.A0A194RMS7"/>
    <dbReference type="InParanoid" id="A0A194RMS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16511">
        <property type="entry name" value="vRING-HC_IRF2BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="182" mass="19862" checksum="EF7E3CE1A35AD2BE" modified="2016-10-05" version="1">MGLWGAQRVVCAEFRTDRSAPRPAADDRCATALLASLATFTLNVHYASRAERLRCPLDANGWFGAGSNGGRRSSGSRHVSSTTSVSSSEAADADPPAPLLKCTLCQERLEDTHFVQCPSQPHHKFCFPCSRDSIKRQQGSEVYCPSGEKCPLANSTVPWAFMQGEIATILGEEFKPKKERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN42</accession>
    <name>A0A194RN42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin-C4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN42"/>
    <dbReference type="FunCoup" id="A0A194RN42">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RN42"/>
    <dbReference type="InParanoid" id="A0A194RN42"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8101" checksum="7EEAA67255ECBC34" modified="2016-10-05" version="1">MASSAEIKQFIKDAVSKDKVVVFSKSYCPYCTLAKDVFAKVKQPITVIELNERDDGSVIQENLAELTGFRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPU4</accession>
    <name>A0A194RPU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="9">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tetradecamer that assembles into a two heptameric rings with a central cavity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="9"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPU4"/>
    <dbReference type="FunCoup" id="A0A194RPU4">
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPU4"/>
    <dbReference type="KEGG" id="pmac:106721544"/>
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    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endopeptidase Clp complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATPase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="27211" checksum="A11A76A8BA4B9EBB" modified="2016-10-05" version="1">MALNYVRHMFKVISTNSQRVHSNIRYISSTNPVRLGMIPIVVEQTGRGERAYDIYSRLLRERIICLMGPINDDISSLVVAQLLFLQSESSKKPVHLYINSPGGNVTAGLGIYDTMQYITPPVATWCVGQACSMASLLLAAGAPGMRHALPNSRIMIHQPSGGVRGQATDIQIQAEEILKLKAQINALYVRHTGLELEKVQTSMERDHFMSPPEAKAFGLIDNVLEHPPSHAMENEAVAATSGSNPAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQD6</accession>
    <name>A0A194RQD6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositide phosphatase SAC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQD6"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A194RQD6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="187"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="627"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1188" mass="134234" checksum="2CE17E79B49A6BEB" modified="2016-10-05" version="1">MELFRSELYYIFVRNESSLWWNRVTGAFSVRSAWDLSDIEDIECLGITEGIIGKVEHSTIYEPRLMIIKESVPVGQIYFHHTIYKIKSICFLNMGVANQEMDLCPCTKHNSSSSMQSSNKTANKKMGSRLFENSAFLNKTVGAVKNVSNTIKTTTQHAATQVKQTVKKQRDPKLAERFEKRLTDELHKIFDDAESFYYSRTLDITNSLQRQYEIEKILESEECEGKTVTDITRWWKHVDDRFFWNKHMLKDIIALDSPQCDEWILPVIQGYVHLAQIAVDADSNPLNVESLASGNTCDDTFTLGLISRRSRYQAGTRYNRRGIEPGGKVANYVETEQIVSIICTDSIHRASFLQVRGSVPIFWSQPEYKFRPPPRLDRGEEETHAAFKKHFEEELKIYKQVCIVNLVEQQGRERVIWEAYGNHVLKFNSPDVIYATFDFHEYCVVIIIIAISSLYVSSEGLGAYPKLGTAIAKYVLELQLCRLGLGTPGCGLPAALRHAFLTMWADNGDVVSRQYAGTKALKGDYTRTGERKFTGMMKDGVASANRFLIRHFNDAMTQCAIDIALGQPIDESTIDELDLWHDVKTASMMVLENLEPSKPRFGMMPSYFGHPMRSELASAQEQTEPDTAAMAQHVKSLIDDCKKLLVDTEPVLGSWGLIDADPHTGDPHETEMDSVMVLTSDAYYVTDYDETSDRLLSVQRVPLSDVTLLELGTLDTNPTIFGVGRKSSTEPVVCIRINYKYNGEPGYFHMFRSTSLRFFNNMAVVINTRDEMIESLHSICESVMVARDVAKLPPVPFHDGVKLEKRKSKIHGASSGGARSALYLDVSRLPSLTRNVSETQLVADIRSVERRQASSLTDAVLEQIIRIVSVRTECRYIPQVNGQVHDAEHTVRSKALNNMTEQFSKLNKLSHSLNAKARPSLQLKFDQGASRTKKIFTIGQNKNDKKKGSLSDGLSSDYSSDDENRTNIFEPTLDNFENTQHYIGKKSTDEKNETENDCELIQNPLYSSKIEPNEVTEIVQDVPETIERLPVKTPNIPKRNPFDIDTTKTPEIQIEGFVKPTPPNTLLLSQKLSHSSSDINYEDDQTSQEVYVRSNSQHEITLNIAQSHSESALRQLKNIASPMSSATREMVLSPLSKLAKGVQTLGANLDPRKIKASGSVKQISEQQYEEHKKLQEKWHGCNTRLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRM0</accession>
    <name>A0A194RRM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CWF19-like protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRM0"/>
    <dbReference type="FunCoup" id="A0A194RRM0">
        <property type="interactions" value="1691"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRM0"/>
    <dbReference type="KEGG" id="pmac:106710869"/>
    <dbReference type="InParanoid" id="A0A194RRM0"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="376"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="507"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="606" mass="70171" checksum="B73CF1E48066B0B0" modified="2016-10-05" version="1">MKEKREKKKKHKKDKLKQKKSKKKAYESDSSSNSTQSDEWVEKDTGSSKNRDEWMSMTGMLKTYTKDDVKVSREDDKKHIDSYNPSTSSRELNPYWKHGGSGLPQSHESFCKSKQFMKPSDDDDYYTKPLSNQGKQMTRTKHEHRDDRNVGERKHYNWQKTEKREEKQNYKSKHDYDTKTNESLNDKRSSASLKGPTETSEKVSDSLYLSDEKMNKLAAKIVKAEIMGDTKLVNQLKVKLEAAREYRKQNPGVCKDDDSGIMLMTTTPSGNSRPLSKADSSHAGDPRSKGGKRKAETHSANQRVKYFGNDDKYNLSQMFEEEKYGTNYDQDAELAAIAAKHRNPNDDLEDIFVDEISKNRNVAKDNEKERQQAINQSMKLERSLEGCEYCIDSKNMLKHLIVSYGSKVYVALPAKKSLVKGHCIITTLQHNTCVTSLDEDIWEEILNYRKMITQFFNSQNKDVVFFETATRLHRYPHLVINCVPLPRDVGDMASIYFKKALLECEAEWSMNKKVVDLKGKNIRKGVPKGLPYFWIDFGMDPGFAHVIEDQQLFPKTFAEEIIGGMLDLNHNLWKNPQREYGNLQRQKVLEFVKEWKPFETSMKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRM2</accession>
    <name>A0A194RRM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lozenge</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRM2"/>
    <dbReference type="STRING" id="76193.A0A194RRM2"/>
    <dbReference type="InParanoid" id="A0A194RRM2"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000004">
        <property type="entry name" value="runt-related transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="439" mass="49017" checksum="4FF96B3DB2FA28F6" modified="2016-10-05" version="1">MHLPYESRGRRRREMAELEPWWLQSIVDDTLVEHPDLVRTGSPDYMCSMLPQHWRSNKTLPGGFKVVALGEVVDGTLVTVRAGNDENITAELRNNTAVMKNRVAKFNDLRFVGRSGRGKSFSLTITVSTSPPQVATYQKAIKVTVDGPREPRSKTSTNVSTHRTIDFHRQFISCPPLPLREEYKNPTSRSLRTLSHEEREYKTNATIPSGEGSGNILGASEWNTGYPSTASVYPTYGSVPLQPPYYKPDPPIHIPTVLPVMPLCHTDYSGFQTGSTSYKSSPSLPGPAITDLNQPPLTNHTPAPMSAQPRCEPNYYNSWPTNTYNYNNYQYNNINNNPTCLQSHTPYISPNPQMILPNLYSTVNQNQIHVHLHSSTDKHNIEQYIPSEIKISDIDGGISITTELQGAGETSGLVQTCEASDDVKHGLYGASNQEVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RTD3</accession>
    <name>A0A194RTD3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">furin</fullName>
            <ecNumber evidence="14">3.4.21.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_11003</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.</text>
            <dbReference type="EC" id="3.4.21.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.75" evidence="14"/>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RTD3"/>
    <dbReference type="STRING" id="76193.A0A194RTD3"/>
    <dbReference type="InParanoid" id="A0A194RTD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF3">
        <property type="entry name" value="FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 16 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="465"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="613"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="770"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ19376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="939" mass="102240" checksum="27C2122A4A25EFEE" modified="2016-10-05" version="1">MRLEWSQWRSGPRWQITLFYVKAVRIFESSVEMIFDNHFHFHHNSVSRRSLRPAVEHHGRLENDVRVHWAKQQRALSRKKRDFQILYNNNTTVETVTSDPYPSVGTKREAGRRELQRARVKGRLRSLDPRFLLNDPKWLHMWYLNRGGGLDMNVIPAWQEGITGRGVVVTILDDGLETDHPDLIANYDPMASYDVNSHDSDPQPRYDMIDSNRHGTRCAGEVAATANNSLCAVGVAFGASVGGVRMLDGDVTDAVEARSLSLNPQHVDIYSASWGPDDDGKTVDGPGELATRAFIEGVTKGRNGKGSIFVWASGNGGREHDNCNCDGYTNSIWTLSISSATERGEVPWYSEMCSSTLATTYSSGAINEKQVVTTDLHHSCTVTHTGTSASAPLAAGICALALQANRDLTWRDMQHIVVRTARPERLSLDGNWRVNGVGRNVSHSFGYGLLDAAGMVRLARSWRTVPPQRRCELAAPRPQRPVPPKSSVVLQLDVSACPGVNYLEHVQARVSLSAARRGDLRIALTSPAGTRVTLLAPRAHDSSRAGFNSWPFMSVHMWGEAPLGVWQLEVSNEGRYMGRATLQEWSLTLYGTSSPAAKNDPIPFRPIITRNKSNATRPVVVQPRKNNRGKTVSSAPTYTVGLVKRKKNKNSKNTKGSQKMKQSHPATRSPIESTTPRVTSTPPNLSLNLQGNLADPLADARGRKMSNLFEQYPKIQRIYPAPLQANGTQCMRAIPLHIRCLQSLSMSATACPGPLTQWELIFYGTETPAQEYDASPETNSLGTNGGGGGGGSAGADGQSGAGAGAGKNPWGGASLPDSEEVRQNGIDDDLALVWHDSHAIREEGLLGSSGSSEASGGGISGCATRAPQLPHRCLGLCLLLALLWAAKAFLAADIQSGDRLCTRDALTASVRSTTGYDRIQPVHAARPPRAPCLVPQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAY9</accession>
    <name>A0A0N0PAY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Thyrotropin-releasing hormone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAY9"/>
    <dbReference type="STRING" id="76193.A0A0N0PAY9"/>
    <dbReference type="InParanoid" id="A0A0N0PAY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="76"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="478"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="838" mass="95496" checksum="CB8BA635B26F098F" modified="2015-12-09" version="1">MNCLVDILSPLRLAHYGPLSRNSVRTETITQPTATLLPAIVKAGLQLEKYEVTEMHYVATSVGLAVPFVELTVAHASVLTILAISFERYYAICEPLRAGYVCTKTRATLICALAWFFAALFTSPILAIAEHHTVTRQDGTVSSQCLTQAVTYWQITFFIMVIILLYVLPLLILIVLYSIIAKNLITAASKVVLNKTVDPYNTRARKQVILMLGTVVLCFFLCLMPYRVLIMWIIVTPSELSDTVSPEKWYNLLYFSRIMLYINSAINPILYNLMSSKFRIGFCKICICHKHFSERTQNRRVQRTATNGSTTSSSLSRTTNSLKKFFSHRSSIEKSDESESKDNKDERKHGFYRMFTSRRFIRQQSAPICPSPKVKKITRMRSEGNMLEVDAFEVDRKTSRAYPKDVAPKFIGHSNVSAKNRTDIEMDSSNRSQGSLRRSVLINSAKGKSFEGDSKNPILGVATFTYEKYDDGTEVPVCLTQADTFWSALFFILIIAIFFIIPLGVLLVLYSVIAKNLMENPVIISQHSKNSNNAGNVLRYRKQVILMLGTVVLSFFVCLLPFKALTLWIIVFPPETIMSLGIDGYYILLYFCRVMLYLNSAINPILYNLMSSKFRDGFVKLLKINKLMRCGRNLRENMQRRDTFNTTTSTGFSSSQNTSESFWRRYSNRASSQKYFLNRSSTKTKEVKEIFDTKVQQVKVGEIINVENTRRNSMTMISAMNELNDNLGEIIKFEDRKRNSLKFIKTVNGIVENGRDVQVDVHENHVNDEPEETSEVNTANNKQIQILNLDVKTNSVYSVTLDVSDTNEGRNRFVCVPSQDKENKNIFVYDFKSNESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBZ1</accession>
    <name>A0A0N0PBZ1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_01797</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="EMBL" id="KQ460731">
        <property type="protein sequence ID" value="KPJ12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBZ1"/>
    <dbReference type="FunCoup" id="A0A0N0PBZ1">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBZ1"/>
    <dbReference type="KEGG" id="pmac:106713385"/>
    <dbReference type="InParanoid" id="A0A0N0PBZ1"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857453" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="465" mass="52944" checksum="C735A2FB19548C85" modified="2015-12-09" version="1">MQNVTYILVFLLGTATAYKNVTKEFVVPLDHFGFQRNETFKIRYIESDEYWNRGNGPIFFYTGNEGQIEEFAKHTGFMWEIAREFEAKIVFAEHRYYGKSMPFGDKSLDNEHIGYLTSAQALADYAQLVNFLQGGKSLKPKYPVIAFGGSYGGMLAAYFRMKYPHLVTGAIAASAPVHMFSDMVPCEVFHRIVTSSFNVASKVCRDNIRQSWNVLRTFVANKTNADWLKKQWNLCVAVNDSKGDVQDLVDYLQTMYETLAMVNYPFATDFLLPLPANPVRSVCQYLSQKLTGQKLLEGIGKVLQVYSNYNGKGDCVDYKNTDYGNLNASGWDYQACTEMVMPMCTNGVDDMFEPRPWNYTQFSEDCHKKYKVYPRPDAAWLEYGGDRLQAASNIIFSNGLLDPWAGGGLLSSISDTIKAVVMIDTAHHLDLMPKNPNDPESVKMARQEHKRNIEQWIRNFRLNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDQ9</accession>
    <name>A0A0N0PDQ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="3">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_01920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="3"/>
    <dbReference type="EMBL" id="KQ460240">
        <property type="protein sequence ID" value="KPJ16389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDQ9"/>
    <dbReference type="FunCoup" id="A0A0N0PDQ9">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDQ9"/>
    <dbReference type="KEGG" id="pmac:106709365"/>
    <dbReference type="InParanoid" id="A0A0N0PDQ9"/>
    <dbReference type="OrthoDB" id="422368at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857253" description="GDP-fucose protein O-fucosyltransferase 2" evidence="13">
        <location>
            <begin position="25"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="407" mass="47572" checksum="3B2A2A434353B400" modified="2015-12-09" version="1">MNLYNKFLLVILHFVIITLLFVAAKDDNGFCDKSGKHCKPGSGEKFLMYDVNPPEGFNLRRDVYMRFAIMLNETQKMGKKLNWRLVLPPWYRLYHWKSGAQNKPLPWHKFFDVNSLKTYVPVIELQEVISNSITPLKIDRLYVLQNYENAFEDGVFHDKWTITDNCKYDGYFWGYNNITVKETVCVNFQGKISKLWELISMHPKDKYVMFSHGEIPLHISYGTKTYWDCRKSMKFNTGLVKTAKNFILQFLDCKIEKCTTYLSVHWRRRDFAYSRGKDVPTLQGTAKQIDQIVKDNVPDIKTIFIATDASETEVKTLENDLKELGYKVHFYIPSKKELDMYKDGGVAIIDQIICSHAAFFVGTYDSTFTFRIQEEREILGFPSSTTFNRLCPDKGKCEKPSKWTIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDU6</accession>
    <name>A0A0N0PDU6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460047">
        <property type="protein sequence ID" value="KPJ18005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDU6"/>
    <dbReference type="FunCoup" id="A0A0N0PDU6">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDU6"/>
    <dbReference type="InParanoid" id="A0A0N0PDU6"/>
    <dbReference type="OMA" id="VWWGIFI"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
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        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="36012" checksum="0F069D39CE01C901" modified="2015-12-09" version="1">MEPLIDRNNFAISAMVTVAMQILFFTIASLFQSDKVTDFTGGANFIIIALLTFFLGQGGSHLKNYDSRQLMVTAFVCVWGARLSIYLIYRIYHIGRDKQFEDRKSNTLRFAVFYTFQAVWVYVVSLPVIIMNSPHHSFPKAPKTMTTLDSAGAGIFVIGLLIETYADLQKFAFRQEAANQGRWCNDGLWRLSRHPNYFGEVVLWWGLFIISLNVIEGIEYIAVLSPLFTTTIILFLSGIPLLERSADEKYRDNPDYLYYKSSTSPLIPIPPAIYVEVPKFLKCVLCCEFPIYDSTGDDFPAPTIATETTSISMVQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE75</accession>
    <name>A0A0N0PE75_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ecdysteroid UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE75"/>
    <dbReference type="STRING" id="76193.A0A0N0PE75"/>
    <dbReference type="InParanoid" id="A0A0N0PE75"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857404" evidence="4">
        <location>
            <begin position="21"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="43924" checksum="E065AB47A5AE10E6" modified="2015-12-09" version="1">MLHFSLCLLLLVGSILNIESSRILAVYPCPSISHQIVFRPLTLELLKLGHELTVVTTDPMFSKENAPANLTEINVHDTTYGVIRKIISNAVTGSKTDLLNQALVVKELIYDATEAILQTNDVQNMLKNEKRYDLIFIEALFTPMLGLSHKFKAPTILVSSFGPFIGSYEIIGAPTKALLYHNMYSQRLHNLTLIEKISELYNYVRIQYIFNYSDEKLNELLKRLFGSDTPTLSKLKDYVDMLFVNTHHVWEGNYPVPPTVIHMGGLHQKPQKPLPEDLQQYLDSSENGVIYFSFGTNVNISNLPQEKIMIFKKVLSELPYNVLWKIEDDNLPGKSKNIKTFKWLPQADLLRPASDPARARHLVDRIRPTSRRREALAGAGCQLIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEL3</accession>
    <name>A0A0N0PEL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicular acetylcholine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEL3"/>
    <dbReference type="FunCoup" id="A0A0N0PEL3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEL3"/>
    <dbReference type="KEGG" id="pmac:106709856"/>
    <dbReference type="InParanoid" id="A0A0N0PEL3"/>
    <dbReference type="OMA" id="TRTPEVW"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005277">
        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17383">
        <property type="entry name" value="MFS_SLC18A3_VAChT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000109">
        <property type="entry name" value="Putative vesicular acetylcholine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF13">
        <property type="entry name" value="VESICULAR ACETYLCHOLINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ20169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="599" mass="66157" checksum="84ABB810BCF91FE8" modified="2015-12-09" version="1">MAEGPQTIWQRIDNSTIPMINLEVREVREILWEKIKEPTSQRKIILVIVSIALLLDNMLYMVIVPIIPDYLRYIGAWGEAGMDHVVTLPPIKEGNRTIIPTQIIPASHEGQDSATGILFASKAIVQLMINPFSGALIDRIGYDIPMMIGLIIMFLSTSIFACGRSYGMLFFARSLQGVGSAFADTSGLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALISLMDGFMLLLVMKPLKTQMKEANEPKPNGTPIWKLLMDPYIAVCAGALMMSNVALAFLEPTISLWMEDNLTKENWKIGMIWLPAFFPHVLGVIITVKMARKYPQQQWLMAAGGLALEGLCCFIIPFATSYKMLMIPICGICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSFAYAVGPIIAGEVVEMIGFTALNLFIAFSNLLYAPVLMYLRHIYDFKPFENEANILMSDPPDKEYQTYSMQDQKPVNGEFKNHLEYSNMSGQIEPVQESNVDISTAGEHYQGYQNYGQGYEQQQGPPQHTTAPRQLPAQPQPSPSNPFRAASVPAQPAQQAPAAPAPGPVRNPFRQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFF2</accession>
    <name>A0A0N0PFF2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hexosaminidase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01027828">
        <property type="protein sequence ID" value="KPJ21171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFF2"/>
    <dbReference type="STRING" id="76193.A0A0N0PFF2"/>
    <dbReference type="InParanoid" id="A0A0N0PFF2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="10001" checksum="DC5AF68E14B7042A" modified="2015-12-09" version="1">MDGIVHFDLKGAPLKIDYLASVFKSIKSWGATGILLEWEDTFPYDSNLKDIGSQRSSSGCGGDGLYSVDDVQTIFRLAKENSLEVVSIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFG5</accession>
    <name>A0A0N0PFG5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01030657">
        <property type="protein sequence ID" value="KPJ21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFG5"/>
    <dbReference type="InParanoid" id="A0A0N0PFG5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7902" checksum="8B4B978CCAB5B243" modified="2015-12-09" version="1">MNKGSNGQPHRECDNELDGFMAPTLLMIGDARALRKDNSEDNLFVYKKKVYDKTRKNEEKDKIIMLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFX1</accession>
    <name>A0A0N0PFX1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Condensin complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040204">
        <property type="protein sequence ID" value="KPJ21352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFX1"/>
    <dbReference type="STRING" id="76193.A0A0N0PFX1"/>
    <dbReference type="InParanoid" id="A0A0N0PFX1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="7">
        <location>
            <begin position="364"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="682" mass="75942" checksum="8B4E0465EA6015C8" modified="2015-12-09" version="1">MSIAKCTRNVPFVLERLCDVDEAVRRAAFLYISAMNVTQLRVRQRVLTLKVGLTERSVRVRRVVEEILIPAWLSSFEGNIVHLLKAIRLDNALDAKDSQYVAGKLLESLFKRLPISELLEWLPTDKTLRLIPAEKLNKETAWYWRHLAEHLQSIDDDETLQTVLPDLVVLTGYIRAIVESPCPSESEDPVGFSTRQYVLQELGLMLRVYDVSDPSGRSSLQDLIADVLTGDYGPLNPEVLRAFVMALELVVPDVSARMEAVNTMISALRDPEEVEVSPAPLPPAMECTEVKLQRARLRVSLNVAMEAQEEAVREQNYALAAECKAKVEDIQKKLEDLNIQPAPPPPPVLTTIKESKSDGATLNKCLVILNAALDTPQLTTLTPILRMIFKELEVEIFKNIEIQINALETVALYAMLDKEFAKEYKSFFFAKLIDTSNEPLVTTALRCVMDLLCVHGVTVINLLKIFIKNIKPFEMYIPDCFSESISESVLCLSPTHSTVIKVLLQLMDSSCATFRLIIVEGFCRLIHLGHLESPSILSRLLLLWFNPATADEDMLRQIIGVFFQTYPISVDGAQEQIQKATLPTLRALANAPSSSPIAEIDQEAVVRFIVSLTRVNHELIDSQGGMAVTLCGALSRCPSRPEAPLACRVLALLSPPRDAQVAADLANTLRDLIKVTEVLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I977</accession>
    <name>A0A0N1I977_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I977"/>
    <dbReference type="STRING" id="76193.A0A0N1I977"/>
    <dbReference type="InParanoid" id="A0A0N1I977"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="31334" checksum="5EBF2EC15BCAF122" modified="2015-12-09" version="1">MSIKKPCYIWDPLLISQCDRLPAVPDRASVVNDLITAYELNNNLQVIRSIPASYNDLKKFHSELYLDHLKSFHELEEDYMTNDKDEEYGIGNGVEDAYKLSKSVFTLSFHKYEPGFYPGSGNIDDIGSLAGKGGYNHPNAARLWTKLTAVVAGVNLDDNIPEHDHWPKYGPDYILSIQPSLTKDLNTEQYINECISKIKYNLKLLDTKTAIYLPLKRKQDREEDIQNDSQHNFVHKQDLREGNLKKETRLNPVKAQVVPEKDNKAVDVYDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAL9</accession>
    <name>A0A0N1IAL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAL9"/>
    <dbReference type="InParanoid" id="A0A0N1IAL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="186" mass="21064" checksum="04FF4B3DAEA1B408" modified="2015-12-09" version="1">MVMYVQGITIILKCFSMHKQDPFYLVFVMHVRKRRNMIMFQKGTIRIVGLPIFVEAKKRPRPRATLLTMHDRLSGYITRLSENDAVLLTNNSKSTTLNFSRSGVQTRPVRQPCAAHSSFYTNPGQLHASRVPTIVEVGPVSLGVAQRSYNSYKTVIEVTNELQSWIVHLIVMGQCINDSSGVARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICV8</accession>
    <name>A0A0N1ICV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptides capa receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICV8"/>
    <dbReference type="InParanoid" id="A0A0N1ICV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF107">
        <property type="entry name" value="NEUROPEPTIDES CAPA RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="11776" checksum="C5D5FE69650BFAA2" modified="2015-12-09" version="1">MAEVFLRPNETEEHFYERCTNASIFDCSEAEMLWCMMGPRRLPLSRIVPLSAVLLLIFLSGVVGNAAVCVVIVRHPAMHTDTNYYLFSLALSDLLLLLFGNFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID29</accession>
    <name>A0A0N1ID29_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="2"/>
    <dbReference type="EMBL" id="LADJ01056848">
        <property type="protein sequence ID" value="KPJ21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID29"/>
    <dbReference type="STRING" id="76193.A0A0N1ID29"/>
    <dbReference type="InParanoid" id="A0A0N1ID29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="208" mass="23323" checksum="5700F2E5DA3B6688" modified="2015-12-09" version="1">MCQVLRSASSWSCGFLEPDTVEQSVHEAYVDTITRAQHYVYIENQFFITLSRTNLNVRNQIGEALFNRIMRAVRGRETFRVFVVLPLLPGFEGEVGAPSGTSLHAVTHWNYQSICRSREAILTRLYEAGVSDPAQYITFHGLRTHAALGGEPVTELVYVHSKLLLADDRTLICGSANINDRSMIGTRDSEIAVLLQVRQLCCVTLSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEU6</accession>
    <name>A0A0N1IEU6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S-adenosylmethionine mitochondrial carrier protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460864">
        <property type="protein sequence ID" value="KPJ11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEU6"/>
    <dbReference type="FunCoup" id="A0A0N1IEU6">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IEU6"/>
    <dbReference type="InParanoid" id="A0A0N1IEU6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="288"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="383" mass="41922" checksum="09737AE73ED0A388" modified="2015-12-09" version="1">MTGSSEDKPKSANFYVASLVGGALAGISVDLTLYPLDTLKTRLQSEQGFQKAGGFRGVYKGLSTVATTSMPTTALFFVSYEATKNVIQPLVLPQYAPLVHMFAASVGELQLVVACNPIRAKFQTMFYICAKFHQEPLSRSGDTFKQTSVNLNIGIYNISLSTVATTSMPTTALFFVSYEATKNVIQPLVLPQYAPLVHMFAASVGELLACVIRVPTEIAKQRKQTYVGLKKISAISILMKAYKADGFKNGLYRGFFSTVARDIPFSLIELPIWELLKTIVKDRNDGVITGFQSALCGSIAGGFTAAVTTPLDLAKTRIMLAEDYAETRKLRIRPVLTSIYMESGLRGLYAGFLPRMMAFTLGGFVYFGVYDDSKRLVENLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFR7</accession>
    <name>A0A0N1IFR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460203">
        <property type="protein sequence ID" value="KPJ17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFR7"/>
    <dbReference type="InParanoid" id="A0A0N1IFR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="396" mass="46663" checksum="9B016118CF99EC9F" modified="2015-12-09" version="1">MVDPNECPAAINVTSTYNSSKSFSGILGRLQENYHCGVCNQIFDIKKSKEHFASKYHEDKLLFAVNKVSDIMYDLDIYKENKDCYQFNANSIKDINNINNDFDGFYDASKPENDFESTDESISDIEEIANPFSYASMAKKPQITPKFIEIDIDGEKMNVRFDSWHMIKNGYHCAICNIIVEYDIIEIHLIDKNHVKLLNEIKTMSPTTQLIKDIENNKKENHINAEEINKKLEIVNKNKKIEINKENNLKDIPKVIEIEKKESIIIEKDENIIENEKKDSIIMNNDKKSIETIVDDENYDIIEDILLNIEEIVFLKRKNVFAKVTLMSYNTLIPTGDRNKYCVLCSMDLHFDILKKHTESRQHIDNMRKYKYLEKYDKHLLRQKERYKKWYQTNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGV0</accession>
    <name>A0A0N1IGV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/hydrogen exchanger 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_04688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGV0"/>
    <dbReference type="STRING" id="76193.A0A0N1IGV0"/>
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    <sequence length="602" mass="66915" checksum="9FB8F3FE3E073C88" modified="2015-12-09" version="1">MFSLGGIAGFCANRYPSFKPYVEICYTDIDVILLVFLPVLVFSTSYAVDSHSFWKSFPQILLVGTLGTLLTSLMLAFMAYYLIESSWNFSTAVLFGVVCAPIYPTEVVKRLKEMSRGKYISVLLLGEGLIGDATAMIEFTAVFGYLAMAISEASQIALLLLRYAGGGILLGIVTGRIIAALLSMTYNDLLCAVTVTLAGAYLTYYVGEKFFYVSGLLGTVIAGVIVSRRKSTVAGDVEQVVAHFWNILSHAANTLVFTMVGVVIFEKVSYVMSVRQVSLIFVTYSTVYCSRLMVYSAMTPILRHIGYGISWQHSMACVWGGLRGPLSLCLALIVLQTPGVADAGEIFIIQTAGLVLLSLLINAITMGKVLKILGLAEISLAKKANMTNCVKRIMLTRDRCISMLKMDKFLADANWDLVQAGTTIKHPYQIQMSKRDDDYEDDTYMGYHYTTCPDCEREIPNYSVTSIANQRVLKAMKISYWRQYEHGKISKDGVRTLVQAVEVAADCDDGRVNLDLLGTLWKPKAHAVWLRRKLVKMMTPEAATVQMPHNRWRQLAYRMVSSVWFDGFIYVMILCNTPVILCEVALRSPSRSVVYVIKSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGZ3</accession>
    <name>A0A0N1IGZ3_PAPMA</name>
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        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
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    </reference>
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            <topology evidence="1 6">Multi-pass membrane protein</topology>
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        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <sequence length="2859" mass="320261" checksum="BE37A6710EFF5F5F" modified="2015-12-09" version="1">MGSQTLEILRQGVWASLTGGWFYDPHQNLFCNTVHLYIWLFLLCLPFSVYLYFPPASVGWIIYCALVALLFTCLKLLNHGLHHMYDTKECIVVQPTGDPANPYAGTAQEEGMEMMRLGVALGSALENDNESATSLEYHKPNNSTIDLKVDVHRKNSSESSMEDSAMSLKPPEAVATTKSDLCVTQTTETPGPSKARANNRIRCAHKRDHRTKTRRTHANRIDELIVEEASRNQMYVNNHPVHVLSEDGTFAKVSRRYHECPHRRCAKSRDFFKEWLYLDTRENGDPYNQHIVRQLSSDSRDNSEPSVGPPSPKKRTAHRRRYNNYPDESCSKSAMALATQPSNMRRNSNSTMSTIQLPLLNSTAQLVSHMRRHSNNADTGFFASVELGEYMMVKAEPPACEAEKNKGKSPGVRRIKSAALEIGCPPPSVSNLSPHPNSAETIGGQVLKNPKNAVIPPPSKSLTRGPHLNLYPKNESGEGCSYPYLTYGSEIVYPIAEISDEMQTSQKETDLDSSGDSYSDYEDEKQFRGFDWDAEQSPAVRSSDSDYENNGSRSPLLDRAADVRIVRSKHHGDGKKPCCDRHSNTKHNAECPNDKMKHVRLKKLSKNEHFESKRPEKQAACECKYNPNGDYFDKASASSKDLLIEKSSLESNDNPEQEQKPEDKKVTEKKLWDHDISNSSSSSENNIDKLRVDDKYDKNAAPETEESQLTCDSKSADERSVYSLDWLFEETSESTLVCCKEGAACAVQEDSQKCPGALGESSSNVPRNLGAIPKQIKNLARSRASSQKENKKRDSRKEREDSQNEDRILLDAVEAQAALVQGLECLFAATNANTVVMPAPSREDRSRSHRQSIRGERESSNKTRKRSIEEVAQTSTNTLLPTSMPLLAAFLNSRVDFIPCCANENAPAELVQYSEEGQRLRPLMDRNHRNRVRKIKRSTRQRNNPALQNSSEKKDKPPSTDNPNSSTNVHFATSFDDTSDGAIHKFMDEYGNWMSYTFDKNGAGRTQAQPATGPDKEDNAKSNNRAKPTEIPDNSQETNGEGSCGSLESDAGNSESISKTKRGDSIDSSNQGSNNPLLSSNNNVSTVVPINTNPTNKRFYVFDGGTGSDQPRSPVAYVTDSLLEQIEAERQSRMGLPSMHINFLMSQQRANQQAQQQQPDTTSANAPSLMPSIGEETVDLNIRNKFSKLMDEIKKANQPKPKSYYKFKLSKCLEIKITMDRLKLLALFDRNLTFRETFVSIMLAISVAVLGSMVLNLGFYKDIYAFWFCFIMAGSQYSLLKSVQPDSASPVHGFNKMVVFSRPVYFCICTAILCGVHNQLEQITVPADENFRSRRSIDEIKPLTVYGFEFNERDFLYVIQEIISKFLLFFPLAFSLGLFPQVNTFLMYLLEQIDMHVFGGNATSSLSAALYCVVRSLAAVGVLYGFAYSGLIEGKKSQHQKHNILFSIFCGLLVPIAYHLSRSASDYTLIWNLIKKHLLPPELYVIQNPDCNPELEKTEPNTLSEDKKNDSESNISKQNSIGSSASKINFSSETNIAKSQKRSQASSVSSLKMDPKGDMNSTNSLKLDPPTETEDKSRDTNTNNSTSNKQDMPDKTDEDMEDPLPKKLQATVNARLKNDVIVCTFLGLCVFGLHCTTVFTTLRPQLNTVLWIIAGSLGWALHYVTPQLRKQQPWLCLAGPVLRQHEHAQFEVTEPARLMIFEKIFVYLCFLERNVLYPAVVIAATAQDAPAIADKYGDTLGALIICVCALKCLRNAYSEPESQYLIVVFAVLVFQLDLASREVSETFLVDYFLMAIIFNKVYEFLLKVQFVVTYIAPWQITWGSAFHAFAQPFSVPHAAMLFLQAALSALLSSPLTPALGSAIFMTSYVRPVKFWERDYNTKRVDQSNTRLSSQLERNLGADDNNLNSIFYEHLTRSLQHYLCGDLMLGRWGQVQQGDCFVLASDYLNCLVHIVEVGNGLVSFQLRGLEFRGTYCQQREVEAISEGPEESSEGVCARWWCGGRVLAPGACWALRWLAWQLAAARYVLEGYSVSDNSAVSMLQVFDFRKVLLTYYVKSIIYYTIQSSKLEEWLASPTIAEALKPMTERSFVDLDPIFNVNLDEDYDFRASGITRSRFCAVYQEWVVVCSARRGAAWRRRAGARDSPLVTLCFALSLLGRRALAAAQHLSASSSVEFFLYGLHALFKGDFRITCARDEWVFTDMALLQTVLAPAVRMALKLHQDHFMFPEEYCSASALYAAISSHAQRLVICHEAAPAWRYNVLRGAPHLLALRHVMDEGNDDYKIIMLNKRFLGFRVIKLNRECVRGLWAGQQQELVYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADSSPQLRALLGGPVSVAGIRRRLADLWTRVRRRCGEGCSSGGACDAVSAEAGTARPPPPPPPAPSLQLSRNSLAGTRGSLASAGKPTSSTLASLAGLLRDHSHDRTQEDASYGSQDSTEARRRSEERGGRRERNMRARSQPGNRNRGRAERAPSARLLCDTRTTLGDVQAHEGSNSWECSWREPPRRAASAKCGHMVPWTLCAAVTWCRGHFVLRSHGAVDTLCCGHMVPWTLCAAVTWCRGHFVLRSHGAVDTLCCGHMVPWTLCAAVTWCRGHFVLRSHGAVDTLCCGHMVPWTLCAAVTWCRGHFVLRYFLNEGTSKDLSKLSKEIRHERESYRELTGRYIEKSEAIPLKETHYSDLSNKESILKKEGKKDSKPKEIKTKIKRSDSGRSELKMNVSVGSKVLIVEPLGVYDCINLGRRIDVQWPSEAQRERGGRNFWGSWVPMAGMDGLVVHKWTPNHRDPKLRSHVDKTILLVQIDDKFVPIAENCVQDLGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHH6</accession>
    <name>A0A0N1IHH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tudor domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460544">
        <property type="protein sequence ID" value="KPJ14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IHH6">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IHH6"/>
    <dbReference type="InParanoid" id="A0A0N1IHH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="490"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="907"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1591" mass="181408" checksum="A2E135CB7A61D7D9" modified="2015-12-09" version="1">MEIQANDAKLMVTNKLKLRQLFPVNIYMLGELSLELLETKDEVYNNNDDDCFLNLTAIIQATETCQGQCLECTKPTTRMCKQCATVLCEVCFNKSHKNFVIFRNHVLQNIEPELSLNNCKVHTEKTLDYYCKDCSKPICMDCLVIGGEKSCKNHNLVSTQEVNEKLLEDLAEICPKVDETYRRLTKTAVDIGHILYNIGNDTGSSELSQIEKEVEQSFSKLSFIVQALKDEAVNKIVQLRTAEKESLENAKKSLAESIKSAKCVLNSVKKSLNVEKIKQANMSLLLEDAKKVVNSPWYLSQNKAEINVVVNEEVCDLLGNFIHLDGETDGTFKLLTTDEIDPNVEIPPPPVAPVFPPELPKDVRVKKNQNKPNIEKNNSKSQTLYTKAPTYHSKSASISSLNSLNSDSSYKSSSNNRDDGLYKPVHQVSPYQENQQPKPLCAGSQELVYISHIVTPHNFYVQRVIHMSMLEELIKEFRNAISLPKPSVNSIAEGKSYLVFNKMDNLWQRCRVNSIDKKDSNKHLYHVFCFDFGSTEVVTIDKLRLLPPARAQTPFPFAINCSLVNCSPLAGAWSSDDALLIQNITDKDYYYHHHHHMPTAGYKPSHSMRSSPFRNNFPPSILSRRSRRAIQFPSGLLPWPSFVDFPSPPGIPDMVCVVNLEKYDVPDANTSDVRVTWARAIVTELPGRGRVRLALPDCGATLVAHWSALRRIEAKFTTLRALATECHLAGVTPLNKKWSPNSVALLHTFRGRPLDLHVDDNRNLCLGVTLYDKTEPEEVVCVNTEMVKYKFAVTIGTFMFNKENILQDCVVTNKLPVDHEKSPQTSKNKTNKIKVLKKTEELPKCTVKKEQLEAKDKGPLRLEAKVLYYQSPSLIYLSLVHQQKTFNTLFENIQKHYSKKKTQGKNNWKVGDKCCTVCRQSQTWRRATILDLQDEDAKVFYSDFACVETVPVATLRELTQEFAAIGYAAMKCHLSGVASADGEDWPSLTKEYLKELLDAYKRVFITKMGNFKDMSMPIEMWVYHTIQGSALEPNTSEWRCLNKKIIEQGLAIPDKSQQDETPNDNADKSDDNMLSFLNVKGSIEEWLQLEPMPTKPLVVQSGSDRSNSSTPECEINFSDDKAKKANTVFISDWMPPEPPQNKEFVGVPTYVDNDGIIYLHEVSQQETLEMIQKALDVRFKNPDPKAKYASWSVGEPCIAMYYLDDKFYRGRILEVNKEASTCLVHYIDYGNDETCNFSNLRKSIALYQLPTQAIKCILNRIEPADKFWDRQTLDYMHKSIVEKKCYIKITGNPIDGIYPIELTYNKLLFNDHLVEFEMAKYSDGSKAVIRRFAPVDNQQIELDESATIETDSAPDYIIEEDDIESANDSYCMESLQGKDWNLLIQEEKEKQMLSGKFLTFKKNTIDDFICNITVINDFKCFELFILHDEAIIKEYEEMFEKLQEYANDMPPLNGIYENKACVAIFNEDGQWYRATILQYSNDTNQIKVKYVDYGNIELVTLAEVREINKEFINLPPLTITATLHDVQVNPAIETSVIAEEYKNTFLDKGPFHVKVINNENDIPSVELRNEKSELVYKDLIENNTFLRSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHU0</accession>
    <name>A0A0N1IHU0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01015782">
        <property type="protein sequence ID" value="KPJ21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHU0"/>
    <dbReference type="InParanoid" id="A0A0N1IHU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="60" mass="6652" checksum="8C07845014FF5DF8" modified="2015-12-09" version="1">MGCKLSQLAASEFTNDPLARPPPTADPRSPLSAKQQYCMLASWKGIFRQIEKTGIILFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJQ5</accession>
    <name>A0A0N1IJQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034028">
        <property type="protein sequence ID" value="KPJ21260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJQ5"/>
    <dbReference type="InParanoid" id="A0A0N1IJQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="299" mass="33412" checksum="664C5B78A5D23BE6" modified="2015-12-09" version="1">MFNSAVHLVKLFILYSKIEARDFELDALNLSTNDDEGFAAIKTNKKLEMVEKGKRNCNKPLRYCDTEDESTPMQKNSGTNNIRMPPATYVSHKDQQPPPTFKTPIASHHSTSENQVKSSHSTYKSMTSFDNTDENNTDNDLVGIPPASFSQDPDSFWKDGAQSPRLNNDTDSIDIPFRIIRDHSRQSSIKQPSPPPIQPLAELKDDDQMSLPGSDTHGHGCCRKVLSELKSLKALISTIYLTISDKNNNANNDTVRETVDFGLPIQTRSQLAAFENKIQNVVASTQYVSFFIANLTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKU4</accession>
    <name>A0A0N1IKU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LADJ01028268">
        <property type="protein sequence ID" value="KPJ21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKU4"/>
    <dbReference type="STRING" id="76193.A0A0N1IKU4"/>
    <dbReference type="InParanoid" id="A0A0N1IKU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="201" mass="22856" checksum="0B9B1AB2B4E316EF" modified="2015-12-09" version="1">MAEDESLLHEYLPVLGYRLSLRPSVSMLLGEDNPVIAEGRAFGVQTLSGTGGLRVGAEFLNKHLKYTTFYYSNPTWENHHLVFMNSGFTQPRSYRYWNPETRAIDFDGLIADLKGAPENSVIILHACAHNPTGIDPTHEQWEKIADVMEERKLFPFFDSAYQGFASGDLDRDAWAVRYFVKRGFELVCAQSYAKNFGLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INE2</accession>
    <name>A0A0N1INE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM49A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INE2"/>
    <dbReference type="STRING" id="76193.A0A0N1INE2"/>
    <dbReference type="InParanoid" id="A0A0N1INE2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="107" mass="12387" checksum="CE8D9B1EA5B8DBAF" modified="2015-12-09" version="1">MGKLLSLLARDESNCCSSPRYDIFLDFENAAPTDTERDVFEEVQRVLLDSERILEEIQCYKGAGKEIREAIADPSRITQERAWRAVKPLVDKLLRCYQHSIELQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPK1</accession>
    <name>A0A0N1IPK1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPK1"/>
    <dbReference type="STRING" id="76193.A0A0N1IPK1"/>
    <dbReference type="InParanoid" id="A0A0N1IPK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="17875" checksum="E7891E9805F621D5" modified="2015-12-09" version="1">MYTTWYSRGESGMHHHQMGQLYHHGPPMIKTEAGVNSDCMMAVDYAPPIKWKPMVKLKQSNNMHHVLDDVIQDAIIYNVASVIGIDYGSHSGCIRDDDFVTVTSRGGCLTSALFLHIADRAMQIVTLLINVNRRPRFALPLFPHLAFKTPPHSRIYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ35</accession>
    <name>A0A0N1IQ35_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ35"/>
    <dbReference type="InParanoid" id="A0A0N1IQ35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="366" mass="41114" checksum="20221F931CFC0F7F" modified="2015-12-09" version="1">MDERLPRSDNSVSVIGRFSVVFSEEKRTSVEDGHVYMMPIDRQSETCLSETSRDLQCRFTYRGIPLTQCLRYTGINKYLSHLQRVPLIELAWVVVSICYNVVAILTAVFISGFSGCMILVVPIYVSEICQESIRGTMTSGVMVFYGLGMLASYLMGGYLSYEGMIYVCLSMSVLGFLFLVLLKESPIHLMRKGLEKLAWVVVSICYNVVAILTAVFISGFSGCMILVVPIYVSEICQESIRGTMTSGVMVFYGLGMLASYLMGGYLSYDGMIYVCLSMSILGFLLLVLLKESPIHLMRKGLEKDAAKVIAYYRGVKVTSKTVEEEIQMIRRAMNPDFDDLTPEVEKLQPELKGKPKMSTWKFFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ98</accession>
    <name>A0A0N1IQ98_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ98"/>
    <dbReference type="STRING" id="76193.A0A0N1IQ98"/>
    <dbReference type="InParanoid" id="A0A0N1IQ98"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="86" mass="9574" checksum="5F70EF3860F17A1F" modified="2015-12-09" version="1">MGASERRRDRRLQHRTIRVVNAFRQGLDSRGSLADAALAEALRKQTALAKRFSHASSVDCEPRDALAPHDIDVERLSSHSHTETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG79</accession>
    <name>A0A0N1PG79_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_00872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460842">
        <property type="protein sequence ID" value="KPJ12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG79"/>
    <dbReference type="FunCoup" id="A0A0N1PG79">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PG79"/>
    <dbReference type="KEGG" id="pmac:106710608"/>
    <dbReference type="KEGG" id="pmac:106714032"/>
    <dbReference type="InParanoid" id="A0A0N1PG79"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="13307" checksum="ACE672314317567F" modified="2015-12-09" version="1">MSLNVVPKDIRGLRACLVCSLIKTFEQFEYYGCDNCDEFLRMKSNKDNVYDCTSNNFDGMIAVMSPEDSWVCKWQRISRFCPGVYAISVSGRLPAGVIREMKSRGIAYRPRDTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGH3</accession>
    <name>A0A0N1PGH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_02068</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
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                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
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                <person name="Chen Y."/>
                <person name="Ding Y."/>
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                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Feng X."/>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
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                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
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                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
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                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460127">
        <property type="protein sequence ID" value="KPJ17581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIR3"/>
    <dbReference type="STRING" id="76193.A0A0N1PIR3"/>
    <dbReference type="InParanoid" id="A0A0N1PIR3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF10">
        <property type="entry name" value="SERINE PROTEASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="22917" checksum="032CAFE449D78C46" modified="2015-12-09" version="1">MPPSVMSTCEPIARNLTAERTGRKAWDKCLEYQNKLIYPCRESNTPSGGMIRLNLCNRKPDSLIIGGEDAYEGEFPHMVLLGYANGTSEKNWGCGGVLVSERFILTAGHCIYSKEFYAPNSRGMRHMKQGYNGTTQICFGDWHKKKDSCNGDSGGPVQIKHPQIYCMYSVIGITSWGRECGHPGQPAIYTRVAAYIPWIESIVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ47</accession>
    <name>A0A0N1PJ47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein CIP2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ47"/>
    <dbReference type="FunCoup" id="A0A0N1PJ47">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ47"/>
    <dbReference type="KEGG" id="pmac:106721205"/>
    <dbReference type="InParanoid" id="A0A0N1PJ47"/>
    <dbReference type="OrthoDB" id="73401at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042510">
        <property type="entry name" value="CIP2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161:SF2">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="665"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="842" mass="93302" checksum="F90CF5A755BAF7B9" modified="2015-12-09" version="1">MEVDGVENWNSGNGNAADAAKFANLKAFVNAAREFEATHSENAINLMTRYLGLIASSCDLSIFSPGRSEVCAFFSSLWRVMSDGRGPHWAGVAVLARAALEPSARHALTHTYKFMPILARLLCNVISNDKKVKLLSVMQDISYGIKISWQESYLSGLMKQLTDWILQPMTEPQHRTIGHKSLTVLVNVCYANLPAIYALMRTVDTKEFVVHLINLKDGGYGGVEVCRLLLCLSGATRGAAATRQADVHSYLCCTMRTFRNAIIDRDATQLLHAYTFINDLCSDPNLRNYVLTYPNFNGPLQDAIKDTEGVCVTAADDTAEPETAVSCLQNILKFLTVLVSLELYSVRAQHGALAALCMKASRLCLPNALELFAAIVTQYRDEGRLPPSLLAVINEGLPALLVPPALEPGKVGLQWLVVVGALCECCETQQSVLKEVTPDSFEDTLYSVLHHTSQSGTIGVESGQHAVVVACRTALVLAPLDQRWEAALCRLLAHHQVRKLLCAGLSSNNTQRRKQVLQLVKHHYFPVDQMNQVFGEGATSLSCMSEGVSCVSGGVSGGVSVGVSREEGEAAWAQRLSPAQEHAIDALVDKLNDALRNDKMCDVATSSVMELYGYKMSCLEQRLHSHTVALQGATEHMASLQHALALLQATNSSQQDVLYTTQMQNEKHKKSIEDLHKQLEDAETTLRGFRAKLAAERLDKEHVKDNIKKECKAEIAKMEAEMRRREKEAEERLQQADVEYKALQKKLEQQCHKNSELANVLSKFEERVRQRERRLEDAAAAETALRKDLEHRDTVIKQLEKSVVEREARLCQVTAQLEEMRRVQEMVAKLMAKTAHTNNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJA3</accession>
    <name>A0A0N1PJA3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01067126">
        <property type="protein sequence ID" value="KPJ21696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJA3"/>
    <dbReference type="STRING" id="76193.A0A0N1PJA3"/>
    <dbReference type="InParanoid" id="A0A0N1PJA3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="17173" checksum="653A2160B92E4874" modified="2015-12-09" version="1">MSIGVGSNSFKRSQHPRSLNPQDRSNSAPNVCINMVQRPITLAEHQRKNNQSNNSPQSNKYLTSGRHNKEDKDKGTDQQSHSTQVRLYQKVANEQTATWIRRNSEATVAHRHPQVQMRCLPLINGEGDAQKENISRSYASSPPPNPLPLPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJW0</accession>
    <name>A0A0N1PJW0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LADJ01024253">
        <property type="protein sequence ID" value="KPJ21128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJW0"/>
    <dbReference type="STRING" id="76193.A0A0N1PJW0"/>
    <dbReference type="InParanoid" id="A0A0N1PJW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="383" mass="43980" checksum="458005EFD0970BA2" modified="2015-12-09" version="1">MKDQVALLRWVKKNIASFGGNPDDITIMGSSAGSSAVDLLMLSPMTKGLFSKVIPESGSNMAVFSAQGNPVENAKAYAKLINFTGNEDDVYALEEFYKTVPEEVLHSFDVFGQKDSTFFFSPCVERDVGQEMFLDDAPVNILKAGKQHKLPMLYGFDEMEGLFRVPWFDHWKDSMNTKFSDFLPGDLHFDSESEKEEVAERIKRFYFGNRPISEETIFRYIDYFTDVMFAYSTLRSVRLQVESGNNNIYLYQFDFVDDSTPLIPYTEIRGADHCAQTFMVIDGWWPNLTEDEVSKDTKKMKKIMRKIWATFITTGKPVSENSDLPQWPPTRANGGPHMCIDKSLKLRGPLIQQRVLFWDEIYDKYYKIPTPPPSPPPRQKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM20</accession>
    <name>A0A194QM20_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM20"/>
    <dbReference type="InParanoid" id="A0A194QM20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="624" mass="71212" checksum="2ABC35D513E792B7" modified="2016-10-05" version="1" fragment="single">EEGDFDPHQHRKIEKPTTYSETMIHMLKGSIGAGILAMPSAVKRLGIIVSIIGLILIGCLATYCILLLIEAQYELCKRWRRGYIAYPKSMMLAVRDGPPSLRWAAMSLYYFVEVVLISWQLGICVIFFVFVAENFKQICDFHGYEASLRLHLCFVLVPTILLNLVKDLKLMTPLSSLSNIVTIFGLILVFFYLIEDDVVLDDEKLRLKRFDDIPIFIGTALFALEAVGVILALEYNMEEPKRFVGMLGLYSIGMITIITLYLIVGVFGYLKYGEEIKATITLNLPQEQKKAQAAKLIFALAIFLTFPLQNFVAYNMVWRRAKKRLPESKHFVTDYCLRVALVIIPWLLAVAVPHLGPFISLFGAFCLSLLGIIFPGLMDLCLWYPNNYGVLHYKYVRDVFIMIPKISFKQSSKKKCPTKIVFPLVRERLLASTLSRNDLGDALSDTFVQESVQPKAYFSSKPPSEPVQVIIEPRIMNDLDYKFNSSTSYESRCELNVTSSLSTLAERPASRNSLAVVDRILSSLLSTLPLVDSPSEVSTYRFVSQYYDNKLFSGQFPWGIVANISTRKKKVLSKKRWMGSMRALRESHLRLMMRQIRQLRQIERLDRSLKRVCSVRVHCDNDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMC0</accession>
    <name>A0A194QMC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMC0"/>
    <dbReference type="InParanoid" id="A0A194QMC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="10923" checksum="4D66056526DE54D4" modified="2016-10-05" version="1">MSKFETLSPKYSASDSADAGVALGAHAHTSGPSVLNYLYFSVRMGCSSVGVASADTTRCGACGRWGGSSHQRVSRSVACARAPLHDSGLDEHILVQNQASNIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMJ2</accession>
    <name>A0A194QMJ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMJ2"/>
    <dbReference type="STRING" id="76193.A0A194QMJ2"/>
    <dbReference type="InParanoid" id="A0A194QMJ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="469" mass="54068" checksum="74F3AB56883BFC97" modified="2016-10-05" version="1">MIRSSLASFNSSRPKWVYPTVEIPIRRQIWFMFAALAIVVVQSKRLDPGPQTFIEKTPAVQNPQKRYVTKEVVVYLTPSQIKAIQEGKGFVSAEPADQAEPAEEIEPETEEQQPEQDELFELSPEELEQSQPAEEEENQAEPAAPVEEPTSEQIEDDPELAWIFRQDDKNFVPSPEDPYAYLRYYPETETQTEQAQPESEEEAEEETEEAQPETQQEQQQRFRLVPFESATERPAPSTTKAPQEEPIRERWLRLLELNRAQLRKQLGSQQTTTTTTTEQPRPDGETTLSRFRFSARYNDQKQAIENEERRKVQLERQRANIRAEGRGNRAPFIIRKDGTIARQRQSGLIKRVKVPTPVLVPIPEPFEVKVPHPFPVPLEIFRPLANQSGKQKKGEAKKTAAAARIENERPRPTTTRRPTTTTTTTTTERPSAQERRIASDNRKEVTVEVPTRQRGQPERITIIRHIWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN75</accession>
    <name>A0A194QN75_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase non-receptor type 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN75"/>
    <dbReference type="STRING" id="76193.A0A194QN75"/>
    <dbReference type="InParanoid" id="A0A194QN75"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="278" mass="30271" checksum="623E7B44865AD12D" modified="2016-10-05" version="1">MGSNISQHSSKGLKGRRARSSGDLCNGDSKSQTESSVCGSVVGEVMGWNRSLPNHLDGNRHLADYSRVNNNYGELGTYNRCQKGGRGLRYRVSKSGSDAEPVWKLQDSQFDQGYGSERSPEEEYVAPLPLAPLAAAASLEEYEAELRNLYPFITEDNTFTVVVEKDGRGLGMSVCGGAGLVRIRRLYPPQPAWRTGRLAPRDLLLAANGVPLAGLSTYEALEVLRTAATRVELRVCRPPSDALESLTPPDPPTPPVRTPHPPHLPPLDPLNCHPLHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNK4</accession>
    <name>A0A194QNK4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNK4"/>
    <dbReference type="FunCoup" id="A0A194QNK4">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNK4"/>
    <dbReference type="InParanoid" id="A0A194QNK4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264510" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19618" checksum="353DC0DE7BD0A10E" modified="2016-10-05" version="1">MSKLYCVFLFLGLAVSLRHVRALSQEEIAAIKTGLRPLIAECGKEFGVDEADFKKAKESGKLESLDPCLFACIGKKMGMINDKGEFDVEKSSETVKKFVKNEDELKKILEVIEKCASVNDEAVSDDKGCDRAVLLHKCMEPYRDQIYSTILKAKWILMKFCTDAEHSLEEHIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPL9</accession>
    <name>A0A194QPL9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPL9"/>
    <dbReference type="STRING" id="76193.A0A194QPL9"/>
    <dbReference type="InParanoid" id="A0A194QPL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="34339" checksum="FB7D0F831ACF34B0" modified="2016-10-05" version="1">MISLFQDGSPLRSYFIEDDVFILDRGFRDSINLLEECGYRPCMPDSLLEGEHQLTTEQANQSRCVTLCRWVVEAVNGHLKRDFKLLRQDYFHRALPHMMQNFQIAAALLNRFGVRFQDSVYANEILEVIRERRNLTNNLANMVQQTNMNRRTTQFQSITADRNNLLYFPRLDYSELILFALGTYQIRQARSYYGEHIRFQGGYRIEVSSGEHDSAGYNLRGNGVTTLIRGRIKSRHISRKQYYVYILIENDVPGRTAIVEYCCSCLVGRRTLGCCAHVTLIWYLRWARHKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ96</accession>
    <name>A0A194QQ96_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ96"/>
    <dbReference type="FunCoup" id="A0A194QQ96">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQ96"/>
    <dbReference type="KEGG" id="pmac:106718794"/>
    <dbReference type="InParanoid" id="A0A194QQ96"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="9872" checksum="85608B7090BE7FF2" modified="2016-10-05" version="1">MGERYNIHSQLEHLQSKYIGTGHADTTKYEWLTNQHRDSCCSYMGHPDLLSYFAIVENESKARVKFNLMEKMLQPCGPPPEKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQR5</accession>
    <name>A0A194QQR5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongin 15 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SIII p15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_11245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (CUL2 or CUL5), a catalytic subunit (RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1, ZYG11B or RAB40C. Interacts with TMF1. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQR5"/>
    <dbReference type="FunCoup" id="A0A194QQR5">
        <property type="interactions" value="1347"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQR5"/>
    <dbReference type="InParanoid" id="A0A194QQR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000016">
        <property type="entry name" value="Transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="16">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ07689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="167" mass="18156" checksum="417FD930477F1246" modified="2016-10-05" version="1">MIARRAIVGSVVALARHDGRKHFCHIDDIMSESTVATGGSTVNVEEQRSLGTAAGSVGDEKVYGGCEGPDAMYVKLVSSDGHEFIVKREHALTSGTIKAMLSGPGQFAENEANEVNFREIPSHVLQKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR13</accession>
    <name>A0A194QR13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane alanyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR13"/>
    <dbReference type="STRING" id="76193.A0A194QR13"/>
    <dbReference type="KEGG" id="pmac:106720408"/>
    <dbReference type="InParanoid" id="A0A194QR13"/>
    <dbReference type="OrthoDB" id="5852408at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="4">
        <location>
            <begin position="361"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="5">
        <location>
            <begin position="617"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ05971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="992" mass="114010" checksum="A91885181521EF1B" modified="2016-10-05" version="1">MARNKRQWKFVIFVTTVLLKVCVISLPIQQNLNYNTNTDEIDATFETTLKPKVHFENLIDVNDSIINEDNEKKLNATNSRNDTTRNVAPSPLRNNVRPGQEVRQHTIQITVDGETFTGRSLMEIQLEHNSREDAIIFHFQDLVITRVMTAILTESNLAQTPFRVRNNRLEINPRLSASSFIVVIEYTGRLNRNGLGLYAGSYDDNTYLAMNLHPTYARRVFPCIDEPNQSSTIRFTFNNIEYDNLVVNSMLEDNSQTQFRPLQGPPHLWGMVAHNLNNAYFPTPNVVLNGRPQVINQEAQASIAINHYYHALNEWTNKPYLEIILNQNERMNIIALPDTDRDWYALSTVCIWEPYVFMEINHSVKQRQLALTRIAEMMSKQWFGYVIHPENWRFQWVTSGLSTYAGYEVLKDFQDGPLDTDNALLDVNTLFVTEVIQESLLRDAYINTQALEPNEDIFDEQDIRHNVNGLLKYKAPAIMRMLRLVLGGANDDFIQLAARALLNSRSLQTVNSLNFYDAINSEWLFGGADIIDNIQDFLEAWVQTTGYPTIHVGLRQGGVLITQERFAFSPVAQRNYEIPITYTTSVDPNFGDDNIHPINVIDGTTTLDMDIDEEEGWIIFNIQAQGYYRVNYDPDLWDNLIEALEDPERRKQIHPLNRAALLDDALNLARASKIDYEIALRIALTMEHETEYAVWKAFVRNMNFLRKRLTAMVEEDEDLDQDIYLRMVRRAIVAFENEIGFEPERVTEPAMVSLTRGLVMDHACRSNYDPCIAVAVDLFYDPNNNEVVNPDIPRDLRPAVYCTMVREGDEDVRTALYERLEIEPSYYERIVILESLACSQDAGFIRTFLEETVANNSPYSAEESVRIFKAVAESSYQNARLALSFISLRTNEIRSRYGGADKLEEIILTLADNMANADLSTDFINWTGSRNNNLDDSEDFAERVATHVDENVDWDNAQLEYVYEWIDENDATTMFVSAILITLSLVITIFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRY2</accession>
    <name>A0A194QRY2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRY2"/>
    <dbReference type="InParanoid" id="A0A194QRY2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="377" mass="41064" checksum="FB1616CB51AD03B0" modified="2016-10-05" version="1">MTKVGQCFFNLIFSRFVAKWRVQCATCRRCPRERRMPRGMGRILIEEDSEMNFTAFSAVGGAGTHFITTGGQLPVAKLQQNISNNGGTMSQVVGVMGGVSLPDGMQYVRTLDGGATLQTPQLITVPIALPGAKPVPVNFTSNTAESSQGAEGSEGVSWRVLDNTELIKYLNSLPPQEAEALPSSLQQYLRLNVKRDWPEDGSATSEEKQVLDADGVLRVKKKKKYKKKPPKPARPKPGQVVIAKASDGTAVYCCPECQMAYPAKEQLEMHLIVHKIERRFICGICGAGKDHLRKHARSHESRRARDGHAAEDKPAILAQSASHDDNMPGITIHVPTSSNSQMPIQISIPQHVVSSLQAQNAPIDAHSQLDALLADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSC0</accession>
    <name>A0A194QSC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSC0"/>
    <dbReference type="InParanoid" id="A0A194QSC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="111" mass="11457" checksum="3AA8279508E27828" modified="2016-10-05" version="1">MANSTRNEVQTVRNLKDNPIKDLLFHGDPTGNAGETHIIVKRQSDRYRYPPRPLPILFGGGGIGGVVVGRGYGARGAPGRGFGARSVGGRGFGARGLGGRGIGGFGGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSM9</accession>
    <name>A0A194QSM9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSM9"/>
    <dbReference type="FunCoup" id="A0A194QSM9">
        <property type="interactions" value="1740"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSM9"/>
    <dbReference type="InParanoid" id="A0A194QSM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="2">
        <location>
            <begin position="367"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120678" checksum="6C16508399AC6E9C" modified="2016-10-05" version="1">MVNPPRAINVIVQQLHSALSSKKRSDGQVNSLIDEFNNLPFTKNECEYFAIHRNIEPLTKLICEEIIPCNEILTSKTSNLLHKLFNKTNHEFSEELWETVTMWRIESLHLCSGNILTDVVFHMHESLPKRTYLLAKHAESLIGSEGLIIKILKDHISNQENCNVDNVKTSVLLVRIISYLTMHLFQNPKKYTVNINKEVIAGTLMELLMNGVPKECEFFYNMALEPALQTLSHLFYHNPDINFSLSDAISIARHFILYGLSIRNTKPEKLTPIEHADVIEPVKISPNAGKKQKLRKPRNNAIENLKKETSDPNVMKDVDQFSSDSVYEPINKKFLDPPQFVEYTDTSTDFSFDMKYRSDVIDFKAIIRQCAAKLFLVIIKVKGKREIFPYWYKFMPNNSEPQHWFNTENGKKSLIFCALTDSSPKGRTSALGVVLTLLSGSRPYLAQAETSTRVNASVVPFPVTLGYMLTCIHIGLINILTREKSESVAIMALKCTAALAQATPYHKLQPGLIDGLIRCTKKFINQKDINIQLGSLVAIGSMISVDPKVDEILRVLKDDEPDVKPENPKTACANEAECDDFEESYPDEDVAVTIERQAHLLKEKYEKSLQLTSWVIVVCFKNFGIVFHNNQIMNRSLPPVPIILETLQVLSAIAFHYLGELLRPHLVMMTELLSDMLRINQPDLTLQCAKTISVIADGMQKLERTEYALSIKESLCVWEKLLHPLCGVLQSRENPNAKAVVCDCIANIGEKCFKEMLRPQQMLCCALLMGSCCDSHPAVRAAAVRALAMAVMYRTLREYIRLRYREVPELDRISDNLLVRLMEASVVSAIDNDKVKMSAMRAIGNLLRILTRENLAYNPTLKPLFETGINRLLGCANHVASMKVRWNACYALGNVLKNEYLFICFQGWQAQVLPALCNLAQTSKNIKVRITAAVALRSCARRWQVGALLPPLWRSLLEALDSAAHLDDFSEYKHKDNLAEQLCVTIAHICCLLEPSDLADILDPLTYHGETAKTMFAEVYHKLLPEDISCFKILQAAKYVNMDLVPQNEIQARALNILKNIFLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSZ8</accession>
    <name>A0A194QSZ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transducin beta-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSZ8"/>
    <dbReference type="STRING" id="76193.A0A194QSZ8"/>
    <dbReference type="InParanoid" id="A0A194QSZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042410">
        <property type="entry name" value="WBSCR13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44321:SF1">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="372" mass="41536" checksum="A99C83BC2C10C48E" modified="2016-10-05" version="1">MVASFNMFEEFINNNARYEHVYITIDVVLKCLMTMHCSHGSVILWDVRNLNQKEHKTLRVNIPFDYASRVAWSPDSKAFIVHTARENNIIVYKIEKKKDGAIGAATPVITFDKVHEENIVGFGISSNGKFMMSCSSKTDMVIWDLKGQQLDRLDTYLMSTHSAKISPCGRFVVATGFSPDVKVMEVCFTKTGEFKQVTKAFELTGHSSGVYDVAFDVDTSHIATISKDGTWKLYHTKIEYSRGESPHVLETGKYTQCAASPNIALSPNAEVLAVAVDSAVEFYDTYTGQLYDTVDNIYSGIINYMCFDASGKYLFVCGDKVVRVLHNVCGYFTTIASCTRLLSQKQTSATTERLNNTIQSCKETLASFGKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTJ7</accession>
    <name>A0A194QTJ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="10">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTJ7"/>
    <dbReference type="FunCoup" id="A0A194QTJ7">
        <property type="interactions" value="2288"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTJ7"/>
    <dbReference type="InParanoid" id="A0A194QTJ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001060">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ08848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="605" mass="69499" checksum="30301DA53EB8C5E4" modified="2016-10-05" version="1">MAKKKGDEKVNQTPQSDNEEQNFDEEPDFDDPEGFVDDIPDEELLADLLEKKPKESDGYENVVVVDGCPQVGPERLEKLQSVINKIFGKFGKIVSDYYPTSENGMTTGYIFLEYDNPQNAAEAVKATNNCKLDKQHTFLVNLFTDFKKYSEIPKEWEPPAPQPFKVQSDLQWYLMDPDAYDQFLVGIGTGVALQVWQNALPEPVLLQERPNWTETYAVWSPLGTYLATFHWRGVALWAGPKNWTETYAVWSPLGTYLATFHWRGVALWAGPKFSQFQKFFHPEARFISFSPCENYIVTFSPSSDRGDDKKLIIWDIRTGQEKRSFPPPDEYVTWPIFRWSKDDKFFARLGADVLSVYETPGFGLLDKKSVKIPGIRDFSWSPTDNVLAYWVAEDKDVPARVTLLELPNRNEIRSKNLFSVADCKIHWQKSGDYLCVKVDRYSKVKKDKNDIKYSGMYYNFEIFHMREKEIPVDSVEIKEPIQAFAWEPVGSKFAIIHGDPANICISFYQVNTGQAPTLLKKFENKPFNHLFWSPLGQFIVLANFGLTGGALEFLDTNDFTIMNVSDHYQSDVYTNVDTDGLDTDQANTVEEVVEFFVKEEQTVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV07</accession>
    <name>A0A194QV07_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain-containing adapter protein with coiled-coil</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV07"/>
    <dbReference type="FunCoup" id="A0A194QV07">
        <property type="interactions" value="2382"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV07"/>
    <dbReference type="InParanoid" id="A0A194QV07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="518" mass="57874" checksum="149A4AD8C6CAB6EA" modified="2016-10-05" version="1">MHARKPQRISDGYFEKHQTHPYQKYNSKIERTNSDYIPETRYASLRSPNGNVFTHGHGHGGHTGHSAHSAHHHYSHVPDQRPHTIPRNSYMQKDSEKERDRDYKSSRNKYTDSVRSPKEKRSKECDREKNNHERCESEKKSRTSSMNCSVSRSSKYDKRSAPVPSVPTGSEWSEHISSSGKKYYYNSISEVSQWEKPREWDSRRTTSKDSTYSARSNRDREKRSRSRSGRRESEQSRSKRSNNASDRYWSGRDDDSHPHERQRPKHSHDAKDGQPQDMDISPDRSTPLSEGSYARDPPRSDNAVPPVVVLDNSNQPTGSLLAAALPRIVATPVSMGSGVSAATGTGGATGMAGGATSLAGAACTDTGGCTPHRDAGPPTPTHSENTDPHAPPLHLDAALPRKMECLGSYSSVVGGPLQHAVPMLTPSLMNYVRADLTAHVAAWPADILEKQANKFTEEAYQLGCLQCTRVSAELKCARSLVRHTEIQATLQEQKVMYLRQQITRLEELKSQNSFMSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV26</accession>
    <name>A0A194QV26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV26"/>
    <dbReference type="InParanoid" id="A0A194QV26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="26521" checksum="F53E28BFC7240C4E" modified="2016-10-05" version="1">MTAVKKALAMRQLDSMFGSLTLEGEGRHSPLVSSTIEHDPHCDVHGRCSTPYRSSLYLHSRESGFYRECISPTNGLIIRRRDSLGISRSPARELEHPSTFPSILRRDRHSPSQTPPRRDTPSPTQRFSSKRHSMGSFPNLSRCNVVNYNRRDSVTSASVRDMKRDYVGSTNSLSRKSSIETKKSSSDSLDNWHITWDTDRHSSIASLAHDEKFPTGLKKPLDMIPKDLRLMVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW53</accession>
    <name>A0A194QW53_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_15336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 10"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW53"/>
    <dbReference type="FunCoup" id="A0A194QW53">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW53"/>
    <dbReference type="InParanoid" id="A0A194QW53"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ09195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="16697" checksum="70F510BB50202B92" modified="2016-10-05" version="1">MCVGEKRKLTIPSSLGYGERGAGNVIPPHATLYFEVELIHIGDSPPTTNVFKEIDADKDNMLSREEVSIELAFQAMDSDGDKELSREEVSEYLKKQMVPADGAEMSEDIKQMLESHDKLVEEIFQHEDKDKNGFISHEEFSGPKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWT1</accession>
    <name>A0A194QWT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWT1"/>
    <dbReference type="STRING" id="76193.A0A194QWT1"/>
    <dbReference type="InParanoid" id="A0A194QWT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="23796" checksum="E508E09B4D61F417" modified="2016-10-05" version="1">MGGIKSTRNRRAFMRTCINVEDAREILTLCAVVAVSQAGLLPAAVHYSPASAVSSQSIVRHDQPAHATKLVATAPVAKLAVAAPAVYHAAPAVYHAAPSVYHSAPAVYHAAPAPAVYHSAPAVYHAAPVAKVLAQPEEVAYPKYDFTYSVADAHSGDNKSQQESRDGDVVKGSYSFHEADGSIRTVEYSADDHSGFNAVVHNTAPTSAPAVIKTPVYTAHAPAYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZI9</accession>
    <name>A0A194QZI9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZI9"/>
    <dbReference type="FunCoup" id="A0A194QZI9">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZI9"/>
    <dbReference type="KEGG" id="pmac:106716974"/>
    <dbReference type="InParanoid" id="A0A194QZI9"/>
    <dbReference type="OMA" id="CQMDIEQ"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="232" mass="26539" checksum="1CB8F2124007862A" modified="2016-10-05" version="1">MFIVGLTGGLATGKSTVLSIFRDNHVAVIDADEVARKVLEPGTKAWKELRNYFGDEVLYPDGKVNRLKLGEIIFDDIEKRRKLNAITHPRIQKAMMSMAMMYFFSGHKYIVMEVPLLFETGKMLAFMHKIITVVCEDHQQLERLCKRNDFSQVVARKRISCQMPLEQKVARSHFVIDNSGSIENTVKQTESIIKVLQRSKFTWYFRVILLIGFLSVAFGVGHIISNLINNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZU2</accession>
    <name>A0A194QZU2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA exonuclease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZU2"/>
    <dbReference type="FunCoup" id="A0A194QZU2">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZU2"/>
    <dbReference type="KEGG" id="pmac:106715494"/>
    <dbReference type="InParanoid" id="A0A194QZU2"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="893"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119083" checksum="CBF85C9769A3DA3D" modified="2016-10-05" version="1">MLPSTGYFKGLNCPFFDSGLCERPYCHFRHVKKEPQNNDGIESDTILQKLVSAAVQKVLQQTESSGSISPTGTATTNEASKANVVQPVPCKATYNPTPIAELNKINNVDSENNEDVNEQRKRHIPVPYTPRKPANMAIKRPVEVNGSFKPFIYIPPPTTYTPGSTENSQLDPYTPKGTVESKETYLPGKETELQEYTPKDNPISTKRSYVPSDKNTHKTKILEYKPTKVTSKPDVAKVTYQPTPRSLAPCFSSDEEDEPDEKKRKLSSDLNGLDDLGPEFDILDQILDEEKCENNPKTNIEGHSTKTKSNKENSEKKDIKNKDEKSEKDRNKSNNSKSDSKEKSKTHDKQSKSKISSKDSERKSSHKSSSKDKDKADKKHSSKSSKHKSSSSKSSEHHSKNSKYDKEDSKKKESSHKQKSHKSSKHHKEKHKEKKEEPEDNNFDSHDNNEELLEMSESDEESITLECKKIFEEYVPVEKPKIVEETVNKDDDNETEEYIPSKKRISRTIDKNIKITPKPQVKPNFKINAAQAMADRMAKIREFHASKTPSNKNEVIQKPPEIQKNNVFTPPSGGNTKIRIAHVPYASTLVNAKKGISHTPDNNKSSPSTSFTSIQTVKKGTQRVAHMPNEKFIDRPGVLEPLASKIPANIRSIYLNMMIDECLKIYLSATDAYARAQHEELATSKKCSTIPIYKNSSVLTVSRLRKEVQECNGVKKSGSDCTALQKIPRPMSGTTSSAGSWSIENKNRTNVIDKNYFSGAKLYNNIQKWILTEEQLQSNGFPRPHSTGERGRAIIYGQKKQNPPKGYIRTCCRCKKDYTVNKKGFPAVKEDCIYHPNNKYRVRGEARYQCCSQDTTSDGCCIASCHVYEYVDYENLKGYIRTMPPETESDDYGVYSLDCEMCYTTHGLDLTRVTVINSACKVVYETLVKPFYPIIDYNTRYSGITEEQMMGVTTTLLEVQATLLSMFNSKTILIGHSLESDFKALKLIHDTVIDTSVLFPHKMGPPYKRALKNLSSEHLKKIIQNSVDGHDSAEDATVCMELLIYKLKEDLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R033</accession>
    <name>A0A194R033_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein KIAA1407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R033"/>
    <dbReference type="FunCoup" id="A0A194R033">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R033"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="670" mass="79815" checksum="68B10ECC92BB6951" modified="2016-10-05" version="1">MKKIDSCKPNLRKEISKYEELDNDIFDFSSDNSEDLIVKHDVNFKPQIKPQKRSNVSNKMKQRKDNIDINDINKKRKTSQDNTLEHNYLPNDIKCVNTDLDFNYNIKTQSVDDNKIPASKINEHRTDLESLLIMMAIDSNVDYKERDDSFQRNILEVETNNDNNQISSTIGKENGKISEVLCIIPFRTEAQNRHNFLGKKYLKKWKIYTDTRRQIKEREIAINKFFDKLTEKKNSTKQSTESVNKTKLHVRDYNTYQHRYKVQQNIIALQKMKLNEQNKIIEQLKYNKIVESSKQSLETMRDEICKTYYQIDRQLKPKIKCLTNELKIREIEEPALVLHCLKVPQFIQRMEKRAREREEKHAMIRERRRQMEEERIRLKQQTELAKAEMDKEEKLKRMKELKEKRKKEKIENIRKKQHAERMRALTVMADIHYEKKLMAKYGINPLRKLMTIKLDNMEKAKSHYLFQIKKNVFLHWMWYTEDMWLERNYMAEDFYRKKILRKTFNSFKQNHRDYKLKLQVAEDYYDLYVSQLVLRLQLAASADDLVWIQSGIGPGQGLDHSSHRIYTCASVNNSLRAHACPTPFLPYPPAPNLSSIDRAFAAIRRLENVIRIFARVKRCSIGFLLSHTGLLRYGRVGERRLCVVEDEVNITIMSKVSDMVKAIVTKQRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0E1</accession>
    <name>A0A194R0E1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0E1"/>
    <dbReference type="FunCoup" id="A0A194R0E1">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0E1"/>
    <dbReference type="InParanoid" id="A0A194R0E1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="245" mass="26336" checksum="EAA8DB805B62299A" modified="2016-10-05" version="1" fragment="single">RSLRISGSGCEEALSSGSSSECEDAHTHAHVQQEFPIEILPNLYLGNSTNSEDCDALARHNIKYVLNVTPDLPNTFEAEGCGINYLKIPIADHWSQNLAVHFPQAIRFIEEAMSARCGVLVHCVAGVSRSVTVTLAYLMQRHRLCLRDAFELVRSRKTDIAPNFHFMRQLHCFERDLGLHEHSASLSKVLQELGVREAGAGAGAVSGGGAVGAGAGACGCAPPAGISPDSGIEFDRWSAARDTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0K6</accession>
    <name>A0A194R0K6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0K6"/>
    <dbReference type="STRING" id="76193.A0A194R0K6"/>
    <dbReference type="KEGG" id="pmac:106716926"/>
    <dbReference type="InParanoid" id="A0A194R0K6"/>
    <dbReference type="OMA" id="YEILVVP"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
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            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
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                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
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</entry>
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            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">Ya'a_city_454_Pm</strain>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="2316" mass="260300" checksum="DC0B9E515E128DCC" modified="2016-10-05" version="1">MGDTGGVTSVTSKMKSRVEEEDESEEEVWDSEDDDETIARIQRAHYAQAAAMNPRRRAPPRPRPMSHKRKLEAVKNFHDFTKKLKKDTGISIRSLVGNNILELSDFSSEDSKSESDGLSEEEFVVNPNAVQELEEENESYIDPVTGDIVECKKTVQRPVSPDNISHHSDVQQNEEPKTLSISDIINEGGIDLSKNVEIAEVETSELCPDKCPEDLLDMKQDEASQDFEESNNVTEIHNEEVKPQDKLNEEAGPVKDEKKPETEEEKKLNNLNAINVRRNIREVMDEKNLDASTLTAQRQESERLARVQEQQRIIREVQRQIAMNRQNKIHQKTLSLLQGGSSILKKSGPGQKLNLPNTVTVKMPSGEIKRTIKHGQVELTKVQKPTTSAIFSQKLGKLDQKPEKKEVVEIVDSSSGEETSSSSSDSDDCIMLSDSEVPPSPEAEEDPANSGLHVNDTYNIPDEQGRVLINIGHPESEEDIFLAPQIARIIKPHQIGGVRFLFDNIIESVERFSNSTGFGCILAHSMGLGKTLQIVSFCDIFLRHTTSKTVLCIMPINTLQNWMVLNIMIVYIIPIYVLNDSHKTLQMRAKVVKDWTATGGVLMIGYELYRLLSMKKDKKPRKKKKAELKAEAEKEKEAQRNDKNEVNEEMQGSESNMSKPSEESRGEKEEGETLNKTDQEIKDKEEKKEDSPADEDKKLLDGYPLQNNLLEYWCMVDFVRPNYLGSKTEFCNMFERPIQNGQCIDSTPQDIRLMRYRAHVLHSLLVGFVQRRSHAVLQSTLPQKEEYVLLVRMTPLQRKLYDKFMNEVVRTTSVPNPLKAFAICCKIWNHPDVLYNFLRKRNEVNMAIEEDLDLEEIGGVTKAGRQTRSRGNPKKAAKPRGSKKPAATIPPNTTGSGNVQDAGTFGNTPFPPNGPYPGPPGLPGQPGMPDSYRSGRPEAPYPPYQEYHNSGQGYYPPNQGYNQEFNSNYYQQPQPPYGNNYPNQYPQNNSDCSQGYNQNYWNNSNYYGNPGYYNNPQYPNSQPQPEFAGNPPPNFNNSQPYPSNFNTMDPNNQPYPNNQIPQYPGNQDNFTNQHRPPFQGPLNQTTPGYPTFDSSASAPTNYPSSQPPQNYSNAPYQPPSFPGNSTSYGSNIPPPYNQYNNPNSNYPAYGNNPTPNQSQSNSLPNQTAVKTEMNVDSNYQTTERKPEPSYPQNNVPFENSYNFHQQNPLYPNQSETGTSGSYPCQYPPFSSNLETKPPLDSAGSPVTSWPITDTIKTEIDKLKLEDKLEMKSESDGEVKIEDLDTKKIVKDETKRDSSKLAASPKNQFVEGPTKDGALSKETTKSDKSESDEAAKKAKQKGKGKDSKKAEKPKAKGRPNAKGRKDRKSSKDKNNEESESEESEKEEKMNKEEELAMVKKAEEMTYDWAAELLKDYVPGIIENSAKMELFFYLLNESIKVGDRLLLFSQSLFTLNLIEDFLEKNYIPGTVSLWQRNVSYYRLDGSTHALEREKLINEFNSNPNIYLFLVSTRAGSLGINLVGANRVIVFDASWNPCHDTQAVCRVYRYGQQKPCFVYRFVMDWCLEKKIYDRQINKQGMADRVVDECNPDAVLSMKEITNLCFDNDEKESEIKDLSEHAEKYVDLLMQGILTKHGTLLSKEPFQHESLLVDRKEKKLSSAEKRLAQRGYELEKKAALAPKPTGAYRAVRTADGTVVQRPVASVRPMQHARWIPADVWRRQGMTAQEMTLPLDVVIPTNSAEKTNIVLKAGQRVMVLKSPKGIYMQLESGKIIAIKTSLKGLQKGSEVKEGTPIGKKVLSNRAAVNIPGSLKNNSAITITSKTGLRPGMQRVMSRPSMLGPNKMRPVLPGQKIAEIRSRLGDMKSYTAMRPKMPMNHARLLRPNLPGSVSITRIPKQIKKPTNIASNESKKMELESDEDPQVLDSDEEEDSPNDSKEQETSEQTNKKEEAERKEDNTECQKSDAPQEAEKDTITEKDQKSNDSEPMVLTTDEKLPPEDALENKSMNETPREIPDAPNNHMNLAHNEMHEPTPIEKKINLLKNYRHQRPFGRPQTESSLTQLERTASTLNNEGIPDFRRNLDDITQSYSPVTDDKTNNKSRKKKSPTKIETNPEPRNIETPVNIERPPIPSSNMSHSVSSLLGSSTQKPRVDPMLGNHLPKPRMSDSIAQNLSLSGPRPNPLGISHDNQISPLRDYTMGQSLDHSKHMAMGPALGNIGLMGGPPVTPNIDVRKVPGSLGDPLSSPMPTGALKPVQPYPTHNPPPEVPYGQYPGYGMGYGAYPNPAYYAGYGGAYYPPYPPTTTPSVPPPDNYLPSNQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1K6</accession>
    <name>A0A194R1K6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferin 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1K6"/>
    <dbReference type="STRING" id="76193.A0A194R1K6"/>
    <dbReference type="InParanoid" id="A0A194R1K6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="466"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="558" mass="62648" checksum="3DFDEF71FAAC3AD8" modified="2016-10-05" version="1">MTIIWVLKMKYQKHASDAIFWYLNELGSRVVANTGIPSDRHHMGKLILQSLKDAPEFIMQIDGATGETDTFQDALEKSVECANAFRTIGLKADDVIVVMAPNFNNLSISIYAAFYLGIIVAGVDSTLGIMELEETFKLRLPKVIFCEKEREEDVAEALRNIKMDVKIVTYNKSEKNISFVEFIEKYGSGTTVDEFKPADLDPVEQLCLLVPTSGTTGTTKCAALTHTNLMIGAPYIWILSTNFPTPIERAILVSPVQWLSATFSIILSPIMRFTRIQTSLPLTTEHTYFLINKYKPSYMMLSPTLMTTLVNPEERDKCDFTSFKVIILAGSAVTQTLIESLKNVTINAEVYIGYGLSEVVSFALNPVSVYPGSIGRPLTHFQYRLVDPNTEEDICEPNVTGELWLKGPSSFKGYYNNPQATAEIYTVDGWIKSGDLLYRDENWNFFYVERLKMLLKYRNHHISPTEVESVIIKHPGVQDVAVTGIPDDECGDLAVACVVPQHNTTITAQEIKDLVKESLADTKQLRGGVIFMKQLPLTSTTKVNRAMLKKIVREMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2P6</accession>
    <name>A0A194R2P6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-processing factor 40-like A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2P6"/>
    <dbReference type="FunCoup" id="A0A194R2P6">
        <property type="interactions" value="2206"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2P6"/>
    <dbReference type="InParanoid" id="A0A194R2P6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="433"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="861" mass="97569" checksum="551FEC402BFF5F28" modified="2016-10-05" version="1">MVSVVSTIIIIFYLSTKREPPTAGTSSPGLISAAPLLPPPMLSGIPPPIPPAVALPPVPGMSTNMPALQPPMGFPPIIPPFTMPPPGFPPFKADLGAPAPDVTPLANQSSPWSEHKAPDGRTYYYNSVTKQSLWEKPDDLKTPAEYTTDAGRVYYHNIETKESSWIIPTELQEIKDKIAAEEAAQAALNADIPPGEVPLPMSPATMQPSSGSSALDEAMAKTLAAIDPNLANSIPIPEEIKPEEIVAPPQVNGTENTEPTQELPYKDKKEAIEAFKELLRERNVPSNATWEQCVKIISKDPRYITFKKLLGKDYRRRHFALNSAPKKNVPSNATWEQCVKIISKDPRYITFKKLNEKKQAFNAYKTQKLKDEREEQRENLEEFLLSCDRVTSLTKYYKCEEMFGNLEIWRCVPDSDRRDIYADCIYTIAKREKEEAKALKKRNMKMLAQVLENMNEITYCSTWSEAQVLLLENSAFKNDVSLLGMDKEDALIVFEQHIRNLEAEYLQEKEQVKKRNKRQQRKNRDNFLALLDNLHEEGKLTSMSLWVELYPVISADIRFSAMLGKSFSQYSTTIVNVILGRYQITSSTKKVIKEILKEKAFEVKPDTTFEEFATIVCEDSKSASLDAGNVKLTYNSLLEKAEARNKEKIKEESKAQKKIESAFKWALSDANVDHLLPWSEVKEKLDLTAPEFTAVPDEEDRIRIYKDFQHEQEDSCMHYHHPKSRKAKRSKKKKRSRSGSLSGSASGRSPSPTGSAGTWSSDERKHKKPKKKHRKHSPQPLAFSSKTFKQKSPTPEEGGISEEEVSRHKSKKAKRSAPSSGDEHEATHKPKKKKDKKEKKEKYINTHLNSQRIQLLSYWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R335</accession>
    <name>A0A194R335_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R335"/>
    <dbReference type="InParanoid" id="A0A194R335"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="416" mass="47667" checksum="CCA62DDA474B893F" modified="2016-10-05" version="1">MTFVNSEWTEEGRVLDIRLYDGAIKVIRQHRQETKVYVDHAKKLYNLCLPIGHKTRLSEKKRRNKTRVSCGSSYGSLLDDIASCLAKGNKRQSLRRTGKKKKNKRTQKISVKQMQLIGGSFNPEAISEQSREEYTGIEMYRKLLFFFLCGRTLTAPQQGIETIADVKPTIFDYPAEVYNLPAHYPDGDSLINVGRSYSSLYDMTTENIDLETTDYNEELTDGYDKITESIARVYESKENTAEIYSNIGLFANNYLPGQRRLEIKKEGNVADVTYSEISNTTDFKTINSTKEKSSKIEGINTEVKPTAVDKKLSDKSKTDEVVTNFSDSKNILDNNQSFGSTVNIKNIANIVEDVPNYETSKPSYFSNGRKGYLNENFIKKGRRKFRTNCRCEKIWNCPKLQITLPRCPDEYFMCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R404</accession>
    <name>A0A194R404_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R404"/>
    <dbReference type="STRING" id="76193.A0A194R404"/>
    <dbReference type="KEGG" id="pmac:106713767"/>
    <dbReference type="InParanoid" id="A0A194R404"/>
    <dbReference type="OMA" id="MERANMD"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9483" checksum="D37BD5F607F353CC" modified="2016-10-05" version="1">MAENNPDSIPSDVENTYTTPANDPKNMQEVTQYVQTLLQTMQDKFQSMSDQIINRIDEMGTRVDELEKNITDLMTQAGVENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4S7</accession>
    <name>A0A194R4S7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4S7"/>
    <dbReference type="InParanoid" id="A0A194R4S7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264913" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="59843" checksum="4EC946E191FE323F" modified="2016-10-05" version="1">MWSIQRILFFVIASIVIAECKTINNARHEVRKFPGNFRFGAATASYQVEGAWDEDGKSENIWDHITHTNPCVVKDCSNGDIADDSYHQYKRDVEMMRELGLDFYRFSLSWTRILPTSFPDKINEAGVQYYNNLIDEMLKYNIKPMVTLYHWDLPQKLQEMGGWTNPNIIDWYSDYARVAFELFGDRVKDWITINEPLQVCYHGYGDNSLAPLLNIKGVADYMCAKNLLLAHAKAYHIYDKEFRPTQGGSIFISLSAQWHDTEHEEFADAAKDANEFTWEIYANPIFSDTGDFPEVMKKRVAAKSIEQGLYRSRLPEFTAEEIDYIRGSSDYFGLNHYSTKYVYRNESVFGYYESPSFYDDMELVTYTKNEWKIGESQFTKFVPWGFYKLLTEIKEAFGNPPVVITENGFATYGGLDDEDRVTYYKHYINSMLDAIEDGSDVRGYTAWSLMDNYEWLQGYTERFGLYEVDYESAERTRTPRKSAFVYKQILRTRELDMHYEPDTDVMTIDKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5J5</accession>
    <name>A0A194R5J5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4758 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5J5"/>
    <dbReference type="FunCoup" id="A0A194R5J5">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5J5"/>
    <dbReference type="KEGG" id="pmac:106713542"/>
    <dbReference type="InParanoid" id="A0A194R5J5"/>
    <dbReference type="OrthoDB" id="6430068at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031866">
        <property type="entry name" value="DUF4758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072">
        <property type="entry name" value="RE48511P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072:SF3">
        <property type="entry name" value="RE48511P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15950">
        <property type="entry name" value="DUF4758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264925" description="DUF4758 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4758" evidence="3">
        <location>
            <begin position="193"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111816" checksum="BA28903DE0953E03" modified="2016-10-05" version="1">MEFRFFALLAFSACLYNNIHAEGPFYNGADKIAPSQAPNGNFITQTVYGFLDFTTTIGNTVMIFSPHSAPPPEPPKTEKPVQENIIETKPPPPSITDVKPEAIKPSKTSDKDKTNKASIPVIASSAISVISSPPKNEINVPKSVIKEQKQIITKVEVVAGPSKIVESISPKQPAKSNKQASQPSKKPKNQPVKSVTNIVSSKVEVKQSPQPSVKINSIVEIKSSQSDEEPAILVTNNNIGEPEYDFLSRQPSEFVEETYKVINLRPSKSIGHKPKNLKNRVHAPTPPPDDDEHPIGLVTTLGGTIVKDGATTIHETSVIGTYISGKYAQVLNSNSKILSPGHRAKIAPSPTHRILKTVAPGIGKNQRHHLEPTPSISNEETATSKTPRRQTNNGSSFKNRQRSQNNDNDNREAPSQNKKFKNRNTSQSQRTQSTRFGRPANTPQLATVSVYSETPAPSFSNRRKSNRNSGHKTTVTPASNNDSSKRGFKPRIQPTAVDQGASASTSIYKFKLNRSPGTGRWQYKTSPKPKVTIRKTGDDEQPTTPNTNPLLDDIQSNDISPQSRSDNDLDLSSSQSGPGTLLENDTEDNSLEKPLPVETIKVEISTPADFRDVYYEIATLKSPYTFQVGRVKNTRVITVTTTIEKRIDPTISFNGQNSPNEPLTENILATASPYGKDHYLLDSSIATLPAITLSSDMETPPLETVTETFSTTQNMLKTHILPVVNDANLTSSLTFVQTYQVTRFVTATKTLPPMDFFQFIPSKTLKEFNSRLDEAGSELHLELDFGDSNEDEEGVNRRVLPAELDLANIGSDFDITDVDKYRDNHLRLKKAHGQNKSNQVTESPNPAVALTPEQAQQLALLRLLNPAAAAQIPNVVTTSKPILKYETVYESHVIPLFNGKSTILSTISRPVATVTKTEYEIGTSSLPALPLQPIQPINPLYPQQQFSLTSTPVVVNTEVVATDSQILKLTFGAKTVYTTLFTTKVVPTMVTSYVTSSIPVQPSAGFPGYYPAPFAPFPYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6X3</accession>
    <name>A0A194R6X3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_10747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6X3"/>
    <dbReference type="FunCoup" id="A0A194R6X3">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6X3"/>
    <dbReference type="InParanoid" id="A0A194R6X3"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264960" description="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="17188" checksum="BB36B217C1C0F4C3" modified="2016-10-05" version="1">MVVLMQVYSRVFLVCGVLLTTQGAPSSPGLPLCVLAWSITEIVRYGYYALNLINSVPQSLLFLRYSTFLILYPLGITGELLCMYHALDEIASEKLFTILMPNTWNFVFNYYYFLIFYMLLYIPLFPVLFGHMLKQRNKMLSKDIKKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R774</accession>
    <name>A0A194R774_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_10857</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R774"/>
    <dbReference type="FunCoup" id="A0A194R774">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R774"/>
    <dbReference type="KEGG" id="pmac:106712329"/>
    <dbReference type="InParanoid" id="A0A194R774"/>
    <dbReference type="OMA" id="WFPCFRE"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF35">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-0944">Nitration</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="13">
        <location>
            <begin position="68"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="356" mass="39994" checksum="33CE6EB9BFA2B86D" modified="2016-10-05" version="1">MEHFGLSHILFEPDKYSPDTLDLLKDEEAREYWLNTCEKLVEKYVNFALTNNDDPTVEIRALKFKTCYVEAIKELRVNPLAHGQLTIRLLLDINETCLRSQGFFDLWKQQKKYENDTALASLRARLNEIDALPTERQRWTEICRGVLAGNMFDWGAQAVADILDCGLYGALQKIQNRPWLCDGLDKWLEKLEKTVHHCAAVFVDNSGVDIVLGILPFIRALLLRGTSVILCANEWPALNDITNLELEEVLRHASLICPVLSSAMASGDLVVRSSGQRGPCLDLRTISVGLCAEMKVRGVDLIILEGMGRALHTNFNARLAVDSLKLAVVKNAWLAQRLGGPLFSVIFIYEDKPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8A9</accession>
    <name>A0A194R8A9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8A9"/>
    <dbReference type="InParanoid" id="A0A194R8A9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="12"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="243"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="508" mass="57931" checksum="DBB858C1642C9C7F" modified="2016-10-05" version="1">MVRGADHCVQTLAVMDVYVHGGAYQIGYGEFAVAKNLIREKEMIIVNFNYRLGPHGFLCLGTPDVPGNAGMKDQVALLRWVKKNIASFGGNPDDVTIIGCSAGSSAVDLLMLSPMTKGLFSKVIPESGSNMAVFSVQGNPVENAKAYAKLINFTGNEDDVYALEEFYKTVPKEVLHSVDVFGQKDSTFFFSPCVERDVGQEMFLDDAPVNILKAGKQHKLPMLYGFAEMEGLFRVPWFDHWTFFFSPCVERDVGQEMFLDDAPVNILKAGKQHKLPMLYGFAEMEGLFRIPWFDFWKDSMNAKFSDFLPGDLHFDSESEKEEVAERIKRFYFGNRQISEETIFRYIDYFTDVMFAYSTLRSVRLQVESGNNNIYLYRFDFVDDSAPLIPYTEIRGADHNAQTYAVIDGVWPNLNEDELSIDMKKMKKIMRKIWATFITTGKPVSENLDLPQWPPTRANGGPHMCIDKSLKLRGPLIQQRVLFWDEIYDKYYKIPTPPPSPPPRHKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R985</accession>
    <name>A0A194R985_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R985"/>
    <dbReference type="InParanoid" id="A0A194R985"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="15806" checksum="FDBAF2DCE5063895" modified="2016-10-05" version="1">MMASKHTDAETADARKPPPAPRHKKPFPRPKPHFQSREFPQPKVQSKTETPLTNDPLWLDSLVREGDHGLTAVEAVKDTPADAAGYVELVEREYDAIASCDKQFAKTVPLSAYAYYHHILWWYKIALLSSVTCKSCFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAV9</accession>
    <name>A0A194RAV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein toll</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAV9"/>
    <dbReference type="STRING" id="76193.A0A194RAV9"/>
    <dbReference type="KEGG" id="pmac:106711537"/>
    <dbReference type="InParanoid" id="A0A194RAV9"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000418">
        <property type="entry name" value="protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265044" evidence="6">
        <location>
            <begin position="30"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1280" mass="146325" checksum="49103E6C671F7DFE" modified="2016-10-05" version="1">MSLQQVSPRNGLFGHVLFWFVIGLNFADQSSLPLKYEAPDDCQWWLRGPNDAHEVSLTCKLRTINSEFDTTNFSVIPSEHTTSLRIECNEEMMYKSSLDDRSFSHLVKLRELVLDNCKIGRWPPGVLSGLRDLRNLTIRTKNTEWAAMSLEIASESFTAIRQLEKLDLSFNNIWSFPENLFCPLTNLVYLNVSANRLQDVSDLGFRERAIHQALISEQDEPSPSASSLSRASCSLDIEVLDASSNHFVLMPENGFMALRRLKELHIHDNEISMVADKALAGLKQLQIIDLSNNKIVALPQDLFKDCRPGIKEIYLQNNSISVLSPSLFANLDQLLALDLSNNHLTSTWINENTFTGLIRMVLLNLSNNRLTKLDPKIFKDLYTLQILNIQHNMLESIAADTFAPMNNLHTLILSFNKINHIDAYALNGLYVLSLLSIDNNHLEELHPEAFRNTSSLQDLNLNGNRLKRVPTALKNMRLLRTLDLGENQLTSLEEHSFVGLHNVYGLRLIGNKIENISKEVFSDLPTLQILNLARNKIKHIDTNAFETLSNLQAIRLDANHLKDIQGLFVNIPSLLWLNVSDNQIEWFDYSVIPTALQWLDLHSNNIKELGNNYRLDKELRLQTLDASFNKMTKIFTYSVPSSVELLFLNDNQITQVEAQTFVGKTNLTRVDLYANQITSMDLNALRLTPVDPGRPLPEFYIGGNPFQCDCTMEWLQRINKLDHLRQHPRVMDLESIYCKLLYNRERTYIPLIEAESSQFLCTYKTHCFTLCHCCDFDACDCEMTCPSNCTCYHDQPWSANIVDCSAAGYAEIPNSIPMDATELYLDGNNFGGLTSHAFIGRKNLKILYANNSNIDALYNNTFSGLKRLTVLHLEKNNIKELLGFELSPLENLRELHLQDNKIHYIDNRTFMELRHLEVLRLEGNKIYSFAVWQFTMNPYLVEISLSRNAWSCDCQYLHKFRNWFKNNLGKVEDADKITCIFDNVTNTIGPLMADFNSTICTSHVGGSSSIIENQVINDYLPLLLISLCVFVLSSALICGLFYWRRELRVWVYYHCGFRMCYKSTAFDEEADKDRLFDAYISYSVKDEAFVAQMLAPGLESTDPSFRLCLHYRDFNASAYVADTIIEAVESSKRTIIVLSKNFINNEWCRFEFKTALHEVLKERRRRLIIILLGELPNRDIDPELRLCLKANTCIEWGDRQFWQKLRFAMPDLRKCQYHRSTVNIYASVSPVGAGRAPAPPPPPPPGKLPPLLGEALAVPAGVHAREAHAHRLPPHAQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBS4</accession>
    <name>A0A194RBS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBS4"/>
    <dbReference type="InParanoid" id="A0A194RBS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03155">
        <property type="entry name" value="CD151_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="377" mass="42080" checksum="83117B7BB4D44725" modified="2016-10-05" version="1">MAEEKKKKDSSALLSKKKKVKPRKSRDADCLSVNFLKCVLHIFNVIFMFAGIGVLIVGAWTVTSRHRFVPLLPTPTYPAIAYLLVIAGGMGVPLCALGCCGLKTENRTSLLCYTYFLLFTFILELGAGGLAYYYEVAVEFELKAELNNTFIANYALDVVVTDAVDLMQSEFKCCGASRYSDWRRSAWHQHDPRLLVPDSCCKTVTSRCGMRDHPSNIYHNRQKQAKPAANRKVFDKSASSGDLTKFQNLGPRRLKPPERSRTKRSSRRTPCPLHHKKQLPISTISDNCKALLPNLDGLQRVQSKTKELAGTAIVESARPLDIPIQTKDQANNSTLQEPPNTKIQPVNNNINVNLGDLNVNSFGRSKNNNYGNFSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC46</accession>
    <name>A0A194RC46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorting nexin-29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194RC46">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC46"/>
    <dbReference type="InParanoid" id="A0A194RC46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
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        <property type="entry name" value="PX_dom_sf"/>
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        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194:SF3">
        <property type="entry name" value="SORTING NEXIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194">
        <property type="entry name" value="SORTING NEXIN-29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="438"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="579" mass="66083" checksum="24ECDB6D5F5D0036" modified="2016-10-05" version="1">MSTYFRKHTSHKVLNEQNNFSCLCHLHLIPSQQSHSNTLWSYCCLHLTKHEKERFKILSNINTPLGYFRAFIRAALNERSLERYLQSWISHGLLSEYYEEDAMVRTREANLLPDIAAGLSTILFALSIDKAVLNDSQQITQTTKPEHVIPLPTPIKASGNVNRKPIRQVITFEEQNDRKKINKIIDPVAQTSTLWNSAPPTCLNSPDPVIVPQLTSTSEPTSSEYKSGLRHFFPDSVKGIDSPSQILTRLSECAKEIFSSSSSIDRNNVSRDDNVSDLSVNCLKIYESDSEEVAGSIDGSTSCLELCFTEDEGGSDEKRVSSILDHREKEFLDLQIKFNQFELISKEKVQKLEKTVGDLSKENERLKDQLKRYMSAVETGIALKNGSEHDEEISSYEKKLVQVAEMHAELMEFNQHLQKRLQDLESASGIEILDYPESNVKVFMPSAFLVGKRTHSYHVYQIFIKVGLEEWNVYHRYAKFHELHTQLKKCHPDIANYKFPPKKTLRKRDANLVEKRRLALQAYLRHVLLVLPELRECTSRAQLITLLPFFGTSSSVKENGVNTSLDQHSSDSISTYDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD83</accession>
    <name>A0A194RD83_PAPMA</name>
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        <submittedName>
            <fullName evidence="4">Centrosomal protein of 120 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD83"/>
    <dbReference type="STRING" id="76193.A0A194RD83"/>
    <dbReference type="InParanoid" id="A0A194RD83"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022136">
        <property type="entry name" value="DUF3668"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12416">
        <property type="entry name" value="DUF3668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3668" evidence="3">
        <location>
            <begin position="160"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="835" mass="95849" checksum="38D1D02CEF515965" modified="2016-10-05" version="1">MDELRGPNIQIVLHVKEGIGFGFLRIPFIVSGSLNGYMLETDPVVPTHAPAFDAELVWEADKRRFRSLRVQNVPIKVEVFTTSTQGRKDKIGYILLSLLGAQPCPSNKFVDRNELRMFHSNEVAYPLSHTPNSAQTGGPVMLTLNEYLNESKKVVSSFDLQPQLICEEGLIQIGLGDQLYVLSFVIGSVENLDMLLPNDINKEAIDCCITYSIFTNNIMTDRVGVTSLSTGSSAQFNQRTSLRLRTHLSALGRYFAECPHLVVKVCVADRDVGICSLDLRKLIPTEDVKRFVSEFCNSEGRLAIHERCYLLRCDDTPLSVRRPYMDVEISLKFISDKAKVQKPNILSARSITQLERGRTESNYDTKLDYRSGSCTQIDRDVGGVSYTNKSAGNTARYKTANGDNILQTSEITELLRKMCESLSQSQEKSQQRPFTTDMQVQCEPEIDIHDDKPERNGDNKRDEQENGDHKQLNCEDAKEKESKNYSEKDVVKQVLPAVEREAIMQKFIDELEDWKERQQELYKCQLGRKEEYHLELLSREWEKRREELEEKLRGGVERCRALAADLSRATEDFRLRGYRNTERERKLLEAKKALEAHYTAKYQELREASQKMEDDMHHQLKLKDMKIEELELKMHTLEKNIEVLKNNMRNMEKDSESRHSGLTKDQTASLIQELRCLEEKLDSAVQSKAFFKEQWGRAVRELHLTKMSSRRHMLSQLRREKSRLNQVGLDTIDDFEMNKGDELNGSDIKKLKDDFYADLLANTPPLESHSAISLPGPDGLDMFMEMKNAPKNSINDKLNELISQRDQLIQQDNPDEAMLKQLNNEIRSILINCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDB7</accession>
    <name>A0A194RDB7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Steroid receptor seven-up, isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDB7"/>
    <dbReference type="STRING" id="76193.A0A194RDB7"/>
    <dbReference type="InParanoid" id="A0A194RDB7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="26067" checksum="D7F30CFFFCEAC020" modified="2016-10-05" version="1">MRLYSNFDEVRLHCIRVYKTSWWQHIPVTLTTAVLRRVLQRVGGSLVRLHIDHNWSALNDRTAHIVGKFCPNLEELKISTRPPPSAPRAGGQWARGASVGGGGRGVPVEVAGPSLPAPGPPGQWRRGEAWPDPGSVATQPRPLTHGCAPAVSRAVTPTGTITHGALVYGGVGGPGLCPRGPDLPPLELGFRGPWREDELLPSTPASQAASTQSGSSAADKGQNVECVVCGDKSSGKHYGQFTCEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDZ1</accession>
    <name>A0A194RDZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDZ1"/>
    <dbReference type="FunCoup" id="A0A194RDZ1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDZ1"/>
    <dbReference type="InParanoid" id="A0A194RDZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08404">
        <property type="entry name" value="C2B_Synaptotagmin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000039">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="167"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="280"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="46079" checksum="E636AB3E37DC4D1C" modified="2016-10-05" version="1">MKILMPHDGPDIAPIESSGEWHSPVFWAVVVCAAGLLAAMLAALACWVARRRATLAHKLGGKRGPDKALVFQPPRRATAVRSPGSATHYLRKSPSPTAAATPATSPPQPQPQPQPQPQLPTTKELSPGGLSPQTPTAPEPLPLSKELADAAATEKVKPTEPENNDGRLGDLHFKLRYEKEKSALVVSVVSCQGLPGREPAGPDPYVKLQLLPDKQHKVKTRVVRKTRCPVYDEDFTFYGLAPHQLAAITLHFVVLSFDSGEAMALCREIQPRSLKMRSVGRGEVLVSLCWQPAAARLTVVLLKARNLPKMDVTGLADPYVKMYLLYNGQRIAKKKTHVKKRTLNPVFNESFVFEVPAAPSASLDHVSLELLVLDWDRVTKNEVIGRLELGAAGTGSARHHWREVQAAPRRQIADWHKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE13</accession>
    <name>A0A194RE13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE13"/>
    <dbReference type="STRING" id="76193.A0A194RE13"/>
    <dbReference type="InParanoid" id="A0A194RE13"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="27236" checksum="1472AC64489438BA" modified="2016-10-05" version="1">MSNSQDKSSNGLGSDPLQRLASFKPPRDLSLGGVKPNKKVFTPNLNVTRSRNKGVPLANSRDHKKNDKDKRDRIDKELEEQKIKSVVGGDDGLDEEVEDFKQSFEIDAPIKLPIDDGWLYSQPKPTVKIKQEVVVKTEPTEYADCPILLFIILQPSDGGEESCVLSGLQEGRIGRLQVRRSGRVTLLLGDTVFEVCPGTKAAFHQEAVSVSVEDAARSARLVSLGPLQHKLTLLPDWQTMFTDMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REH6</accession>
    <name>A0A194REH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oocyte zinc finger protein XlCOF28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REH6"/>
    <dbReference type="FunCoup" id="A0A194REH6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194REH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="770" mass="88654" checksum="D32AF1BF05F0ABE7" modified="2016-10-05" version="1">MRSVSSHLLEDKMDDAVTHYINSHQSTEAVHVDANSLALNVQDDGGGRVVTVMQPLSFSTSQMCRQVSVNDQVSEGQWSEELMDPESRLAAIVAHLSRPSNHQTHHKISAVRNDVDTSVILDAPMRLYNGPPLDSTMLTEQDRQVLDIAASASPVQNKHQSKKSLPHKKRISKKLKRNTGNSTPQQEQIVVIHCNPQVSQEEILPDNFVGGVPHPDHLAPEPHHIAHDMRPILLCQLCGEFYGEDQVKFYHHLRQHYEPHGTIIIENPVPDLSIDKMTNTCIVDNVQTLPDSLVELSLENTVPKSIYQPIDKHILYTTSDKTLSCHNKVQYTMAGEKELPQDNNKADLYDTFGKLDLYNCPKCDKSFKKQKQCEEHVKDAHLNPKPPRGNQPRPHAPVNIVITDQQQNRQPNQGGRYPIQGYNTDKPWSDLKYHKASIHSDQKNFKCEFCDKEFARRYSLNVHRRIHTGERNYKCDYCNKTFRASSYRLSHMRTHTGSKPYKCPQCEKCFRVAYDLRRHMLIHEKVRLRVDEMKPKSKDSKDKKSKPEEPKPKAQEVKPTKKSAPNRLPILKSMLDKKQPTKTTKKTQTKKGAPNVTVAPNKDVAMKMNDKYTNNVEVFDTRQVEYNKYKDVFEYRGNEVLQGYKKDYSEEMVYKESDRLTEERELAVLRPMFRNTPPIEELEKNNMRSENTDGNFQVFTHIEKNTDGNFHVYTHADKSKNYIIPTSASQSDMKLDREMIREVRNDGLSSDNMDNVFLERLSAFYNITAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF04</accession>
    <name>A0A194RF04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF04"/>
    <dbReference type="InParanoid" id="A0A194RF04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="82" mass="10016" checksum="C3CD821BDE357139" modified="2016-10-05" version="1">MYICKSKLEKHIGTWWDSNPGLQFKWKDERLMLQGKVERTRLRGKSPMRWIDEIKEVVAVSMHKCALKAEIREEWRRFLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF54</accession>
    <name>A0A194RF54_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitric oxide synthase-interacting protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF54"/>
    <dbReference type="FunCoup" id="A0A194RF54">
        <property type="interactions" value="1506"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF54"/>
    <dbReference type="KEGG" id="pmac:106709587"/>
    <dbReference type="InParanoid" id="A0A194RF54"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000251">
        <property type="entry name" value="Nitric oxide synthase-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000601">
        <property type="entry name" value="Nitric oxide synthase-interacting protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="32404" checksum="40DB9347302654BC" modified="2016-10-05" version="1">MTRHARNCTAGAVYTYHEKKKDAAASGYGTQSERVGKDSLKSFDCCSLTLQPCRNPVVTKDGYLFDKEAILEYIIAKKTEYTRKLKQYEKQLKKDEAEKKELADAEKEANLIKFMSREKNISNSSSSSQPSSSSSVSNLANGKHKELPSFWVPSQLPDAKLSKIQKPDPTVYCPISGKPLKMKDLIEVNWTLVKDPDDKKSLIAKENRYMCPVTHDILSNAVPCAIIRTTGHVVTMECVDKIIKKDWLHPLTGDKLKEKDIIPLQRGGTGYALTNQNLEGKNERPVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGB9</accession>
    <name>A0A194RGB9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Osiris 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGB9"/>
    <dbReference type="FunCoup" id="A0A194RGB9">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106709016"/>
    <dbReference type="InParanoid" id="A0A194RGB9"/>
    <dbReference type="OMA" id="DWGSAWG"/>
    <dbReference type="OrthoDB" id="7303967at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF15">
        <property type="entry name" value="OSIRIS 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28077" checksum="C1621D5977EE139E" modified="2016-10-05" version="1">MSSTFRIALVSLICAVVVAGRVHGPRRSRRMDAEDYIQNEVDSGRADESSWWQSPEFSMLQKVYDDCSAHKHLTTCLKGKALTALTRAVEQENVQLADGLTLVKQSDAPPAIAEPRFFPGMSAEEKLDTMLRRKFEQLLNTHSVSLDLSTEGRGRGKKVLPYMMLGVLTTVSIVGGMALKTLAVIAGKALIASKVALTIAGIIALRKLFGQEGPAAETTFQVHADGHHRRNLYVVRPVKESALDPYLYKGEQPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH24</accession>
    <name>A0A194RH24_PAPMA</name>
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        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RH24"/>
    <dbReference type="InParanoid" id="A0A194RH24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="430" mass="48901" checksum="367A5EFDEC8C9959" modified="2016-10-05" version="1" fragment="single">NTTNICAEWEYDDPNSFVAEYNLANQEWKRTLVGSMHSLGIMAGLLIVGPLSDRFGRKKVLVVTGTLGGVFGVAKSFSPWYWFYCVLEFLEAAIGDCCSPCYILMTEIVSGNQRIIFTLMCILGHPFGTFMTALVAWLFPFWKTYLRILYAPCLLYVLYIFFLDESPRWLLIKKKKAKAASILEKAVRRNNLLLEKNVLENIACEDCVKTDFLNVLKTTFQSKLLRKRFFVCLVWWTTSTFVNYGMSINAVTLYGNKYVNFALLGIVEALGMFMMTFIMIRFRRKYPLMSCFFAAAILCISQPFVPKNLSWLSILLYMIGKLMTSLYFGITYLYTSELYPTLTRNSMHALCSSLGRIGAIIAPQTPLLMEYWSGFPPLIFGLVSTFAGLLTITVPDISNQALPDTVRQAEELGVPDVQMSPHITKDHTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH70</accession>
    <name>A0A194RH70_PAPMA</name>
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        <submittedName>
            <fullName evidence="3">Post-GPI attachment to proteins factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH70"/>
    <dbReference type="FunCoup" id="A0A194RH70">
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    <dbReference type="STRING" id="76193.A0A194RH70"/>
    <dbReference type="KEGG" id="pmac:106710597"/>
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    <dbReference type="OrthoDB" id="68581at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF17">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="279" mass="32173" checksum="7511528DCE99334B" modified="2016-10-05" version="1">MENDAQSQLPQNSNLDHSNEKINVNRTIKILEYKGLLWTCALREICLIALWLPLGALIFCYVTASIFQSDDIHETHCRVYNVVPSISAITGISPQRYVWRICIAYHLGPRLLIGSLYYNYHKERTSHITEEKVRNQAIKLGDACYWLNLLELFALTGVTYVSNRENYFVHEKIFIVFMVASLLHMLCRARVGSIGSEAVEPVRTNKLVWILFYLAIAATIGLIIFFLRHRLLCRPLAFTWFSICEYILATTNMAFHAIVVRDLPLHQIQVVCPDRQKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH94</accession>
    <name>A0A194RH94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-catulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH94"/>
    <dbReference type="STRING" id="76193.A0A194RH94"/>
    <dbReference type="InParanoid" id="A0A194RH94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10269" checksum="78F4DBFEDA1555BC" modified="2016-10-05" version="1">MDTLSDDDEYARREPQISSLVATRGEAAGGAAVQRVGAAVCCAVERFVAVGETIADDNPDVRHSMVLACKEARAAGKDVNSEYHRFCSRLTPAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHQ2</accession>
    <name>A0A194RHQ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein krueppel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHQ2"/>
    <dbReference type="STRING" id="76193.A0A194RHQ2"/>
    <dbReference type="InParanoid" id="A0A194RHQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002373">
        <property type="entry name" value="Protein krueppel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="278" mass="30735" checksum="19656F020DF4313B" modified="2016-10-05" version="1">MRQESLPMLAERLLASRAAALVAGLPAELYSGALLAAWPPSPPAPLLPPPELDRTRKRRRTPKLDDSAATAPPSPPSSGSSPGAADPPRDKLFTCKVCSRSFGYKHVLQNHERTHTGEKPFECGECHKRFTRDHHLKTHLRLHTGEKPYSCPHCPRHFVQVANLRRHLRVHTGERPYACARCPARFSDSNQLKAHALVHEGDAPFACRCGARFRRRQAAALHRCAGTGCEADAPSPPAAASADWRWDDWPEQTEPEDLSLPRRPATPDSPTDLRVHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHT4</accession>
    <name>A0A194RHT4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein Meis1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHT4"/>
    <dbReference type="STRING" id="76193.A0A194RHT4"/>
    <dbReference type="InParanoid" id="A0A194RHT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIS N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="21699" checksum="9862CD33064743BA" modified="2016-10-05" version="1">MYHEHRLAHAHLPPVHYAPPAAAAHAAHAAHALPGEPLVHKRDKDAIYGHPLFPLLALIFEKCELATCTPRDPGVAGGDVCSSESFNEDIAVFSKQVYLHKYTTLSLTYFIGNNLDENSGSGCIVNVQSSRGPAAFPATRCVSAERVGSVSRSIGASQSVSTSWCWPVGAGQSVSASQGAVSFLFSDRSSDCNQLGNCLIGPLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI11</accession>
    <name>A0A194RI11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Esterase FE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI11"/>
    <dbReference type="KEGG" id="pmac:106708631"/>
    <dbReference type="InParanoid" id="A0A194RI11"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="588" mass="67675" checksum="D831E6888D570602" modified="2016-10-05" version="1">MWWLVFLFFGCVYAEGDFRTVELEQGFIRGEKYWDGDYYEFYGVPYATAPKGRDKYKGPLPVEPWKGVFDAKIRNTVCYQTYYTGEEDEETILSGDEDCLVINLLVPKVATEKNLVPVMVYIHSGAFSGGNGNMAKFQYLVRHDIIVISFNYRLGALGFACLGNEVIPGNAGLKDQVAALKWINKNVIKFGGDPTKVTLAGFSVGAAMAELLTFTKSTEGLIDKLILESGSVLSPFTINRDPISTATNIAISMGYNGTGDLDDLTEFYLNATPEVLVSKSLNFFLPNSTFGFSPCIENFHEGIEPFLTESPTDILKNGENQKLPVLTGFANMEGISRLIQFGKWRTAMTENFSEFLPVDLKFSDEKLKEEIAKEIKQHYFKGEEVNLENIQSYVNYFSDSMFKYSIMKSAKHHAATSNKPTYLYEFAYVGNMNIKHNYMDRIHGASHRDQTAYLLDFFTWSNTYKDLDTRDRMTLMWSDFVKYGDPTAYESSLINFKWRPFTNKKAIYLQIDKVLTMKRNLFQEEYNFWDKIYEKYYWNPEPPKKVEIKKDEKKILQTENENIQAKKKNKDDNNEKDKRKRKRKTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI39</accession>
    <name>A0A194RI39_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI39"/>
    <dbReference type="FunCoup" id="A0A194RI39">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RI39"/>
    <dbReference type="KEGG" id="pmac:106708740"/>
    <dbReference type="InParanoid" id="A0A194RI39"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="20218" checksum="B34AF9BEC2BEE118" modified="2016-10-05" version="1">MALSTFLRAPVCTNQAFSKQIMRLATFSATNGSSLTAPTLPSVVPLKNIVGKSDIAPITNSVRSFRTSAVRMSDEKPHDHSKLWVIEKGVSALLVPLIPLGLLVPNKLFDSILAILITAHSFWGLEAIAVDYVRASIFGPVIPKIAIGLVYLLSIATLGGLFYVISHDVGIANTVRQLWSVKSNSHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RID6</accession>
    <name>A0A194RID6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bilin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RID6"/>
    <dbReference type="InParanoid" id="A0A194RID6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF62">
        <property type="entry name" value="LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012701029" evidence="2">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="14665" checksum="E756115BF29417F8" modified="2016-10-05" version="1">MHCYILFSLIAVVSASSNVIYEGPCPHVKPQQNFDFASYQGTWYEIARYPNAGEEGARGKCTIAEYLIHGYGTGRVKNSHVIDGVRSFIEGDLTLVGPARIRLTYTFDGLSKDSYLTVLNTDYTNYAIGYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIT7</accession>
    <name>A0A194RIT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIT7"/>
    <dbReference type="STRING" id="76193.A0A194RIT7"/>
    <dbReference type="KEGG" id="pmac:106709896"/>
    <dbReference type="InParanoid" id="A0A194RIT7"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265228" evidence="3">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="330" mass="35622" checksum="F0AEBDCDFE166601" modified="2016-10-05" version="1">MWPLLAVFAAALALALAVGFYQKKTNAVCSSRRRLDGRTALVTGGTAGMGLRIARDLAARGARVIIACPYPREGAAAERALRERTGSKDVVYKHLDLGSLQSVRKFAADVLESEERLDLLINNAGVGIVGDFLTKDGLNFIMQVNYFGHFLLTLLLMPLLRRSGCAADPSRVVNTTSVLRHIGRIDLDKINATGYWFKVQIYGNSKLALVVWARELSARLRGAGVPVVINSVDPGAVGTAIFDCIGSVKGMFVTLLFRSLFKTPWQGAQTALHASLDERAGEVSGEVFKNCRAVGGGGACGPETARRLWQCSAQLVRLDDNELARCLADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ69</accession>
    <name>A0A194RJ69_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ69"/>
    <dbReference type="STRING" id="76193.A0A194RJ69"/>
    <dbReference type="InParanoid" id="A0A194RJ69"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="755" mass="80899" checksum="D174EA0894650BDE" modified="2016-10-05" version="1">MEGEETQEGSAEEPEEVVVDPATVHELATRGDDDTLAILLKRYPQLALATDTSGSTALHAAARGGRAGCAALLLRAGADASAADADGWSPLRAAAWAGHSEVVEVLLEHGCDVDCVDADNRTALRAGRTALGAAASAGHARTVRLLLFWGACVDNMDAEGRTVLSTAAAQGNVEVVRQLLDRGLDEHHRDNSGWTPLHYAAFEGHVEVCEALLEAGAKVNEADNDGKGALMLAAQEGHTRLVALLLDDWAAPVDQHAHDGKTALRLAALEGHFETVAALQERGADVDALDADRRSTLYVLALDNRLAMARQLLACGASVHCSDSEGRTPLHVSAWQGHTEMVNLLITVGGARVDGRDRCARTALHAAAWRGRTAALKALLRHGASPSAVCTQGATPLGIAAQEGHEECVLWLLQHGADPMQADHCGRTPAKVAWRAGHANICRLLERWAAPSAPAVPIATAAPPVPALEELPRPRPAGSPDYKRRSVHSSNSTKSSSNLTGGSARSHEQPEQDMSTHDKTNRANLSLSFAQQVARCGRSRREKERDEPIPEHHAVEKDAKLRSYIANERDAELQGYARARGRGRDRRREERHGCDRDTSPLYASPPRSPLSDVCSPTAPTPAPPRPTRSTALSRIRQRYLTCLLLITNITLSGSQPASLSGVQPVVTDTHFNRDTHMRIILGRDNKTPGDRQDSKNKRNGIVTNPAMRLVNNVRNGLDNAAANIRRTGVALAASASSANPAVKTNAFQWRKETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJP1</accession>
    <name>A0A194RJP1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">39S ribosomal protein L12, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJP1"/>
    <dbReference type="FunCoup" id="A0A194RJP1">
        <property type="interactions" value="1383"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJP1"/>
    <dbReference type="KEGG" id="pmac:106708013"/>
    <dbReference type="InParanoid" id="A0A194RJP1"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="19849" checksum="8FF086B2BA968B21" modified="2016-10-05" version="1">MNTVRIIKNISFRQWRTFSRSSVIRQDVSEAIKPLTIPPPEGVDKPVSPKIEKIVADITNLNLLEVSELSQVLKKRLNLPDAPAMPIGGFAMAAPAAQEEEEAAPKAVKTNFTVKMTKFDDKQKVALIKEVKSLLEGFNLVQAKKFVESVPTVVKADISKDEAEKLKEALTKVGAVIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJP5</accession>
    <name>A0A194RJP5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJP5"/>
    <dbReference type="FunCoup" id="A0A194RJP5">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJP5"/>
    <dbReference type="KEGG" id="pmac:106707996"/>
    <dbReference type="InParanoid" id="A0A194RJP5"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="187"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="33662" checksum="74468FE651753BF9" modified="2016-10-05" version="1">MATGVSTRCLLTLSKRGFSSKADKNVAFLGLGNMGGYMAANLVKKGFNVRGYDPSKDALTAAAKNGISGANSIAAAVDGVDVVVSILPSNKVVLDAYLGKDGVVKHATKGALLIDSSTVDPNVPKQIFPVATENGVNFIDAPVSGGVMGAQNATLAFMAGGRKDDFTRSLPMLQAMGAKHFHCGEVGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLDPQVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFVFQLLKEEAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJQ9</accession>
    <name>A0A194RJQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Serine protease easter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_11911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJQ9"/>
    <dbReference type="FunCoup" id="A0A194RJQ9">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJQ9"/>
    <dbReference type="InParanoid" id="A0A194RJQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000078">
        <property type="entry name" value="Serine protease H137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265265" evidence="12">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="93"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="403"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="663" mass="73516" checksum="B007C377A9AEF088" modified="2016-10-05" version="1">MRSHPTVLFCVLFAALTNALKQCNDCVKITNCASAIQLIRTDRSAAAIQQLQNALCGFEGVQKLNIISLSEIENHRNIRLLPTECGDVDGNRIVGGTSAGLYEFPWLALISYRDNEGKLNFKCGGTVINARYVLTAAHCIKNQQIVGVRIGDYDISQPEDCVGEDEIRECESKFQDIAVSHKIHHRGYVTQPYILNDIGLLRLARPVDFSYRNSGSICLPITKDLREKDLVGERGVVAGWGMTDIQTKSNILLKVELPIFSESSCNMLYKSTSRQLGPGRMTNTFCAGEIGHDSCKGDSGGPLMLESYYDEQCDDCVKITDCAPAIQLIRTDKSAAAIQKLKNALCGYEGVQKVCCSDFFTSRSLNDENESKINTLTSGDEIENHRNIRLLPTECGDVDGNRIVGGTSSGLYEFPWLALISYIHGRTLQFKCGGSVITARYVLTAAHCIEKKQIVGVRIGDYDISKPEDCVGEDEIRECESKFQDIAVTHKISHPNYVIVPISLNDIGLLRLATPVDFSYRNSGTICLPIMRDLRERDIALESATVAGWGATENQRQSNILLKVQVPIYPETTCKSFYKRAMQSRIFKPNMKMNTICAGDEGRDSCKGDSGGPLMIEAPYNGTYKFVQFGIVSYGFEQCGLSKPGIYTDVRKYMKWILDTIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK09</accession>
    <name>A0A194RK09_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK09"/>
    <dbReference type="SMR" id="A0A194RK09"/>
    <dbReference type="FunCoup" id="A0A194RK09">
        <property type="interactions" value="1170"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RK09"/>
    <dbReference type="KEGG" id="pmac:106707999"/>
    <dbReference type="InParanoid" id="A0A194RK09"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="15172" checksum="C4A875E4E82113F8" modified="2016-10-05" version="1">MSEGTATIRTRKFMTNRLLARKQMVCDVLHPGKPTVSKTEIREKLAKMYKVTPDVVFVFGFKTNFGGGKSTGFALIYDTLDLAKKFEPKHRLARHGLYEKKRPTRKQRKERKNRMKKVRGTKKSKVGAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLC4</accession>
    <name>A0A194RLC4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLC4"/>
    <dbReference type="InParanoid" id="A0A194RLC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019326">
        <property type="entry name" value="NDNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055271">
        <property type="entry name" value="NDNF_Fn(III)_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619">
        <property type="entry name" value="NEURON-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619:SF3">
        <property type="entry name" value="PROTEIN NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10179">
        <property type="entry name" value="NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="141"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="461"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="571" mass="63846" checksum="CA66D5A1EFD3C0FD" modified="2016-10-05" version="1">MESLFMASNNTPIDVGVGRPQRARDAPLTRLRSRIDRHWLPIDNQTLYKLDRGESKSLELNTSLIPESRVFITISPCSSSFHWGLYKGSAEDNEGNLSLLEEYEGMDMKTLSVIIRPQEKYILQLSASSGGTVAVSVRGESTRRVRLRLRVRSRRRLSANWDPSPIDPQSTTYCVVASHRKNYTSLCAAQSDVRASRSENKASRFNSEENRSNPEMDSSNQRDRSSNATHHSTSVEADNKVELDIDGLNIYEGNFKNIYRRKKFGRSTKVSSEDPLIACVGDRTHHVIENLDPSITYYVSIFSVSRDRRAGSLLATGTVRPRTSAAKRLRENVPLRNEIKGKTVYYFKAGVGVGGGIWVAISSCGGAVDVEVLVKGKRLYMAKSIEPHSKFFVAAPMLTSSIQETSDEGSVQFDSSSEESKLRYIIRIVPSKWNRDETINVELVTSTTRWGISSPELFDEGGIVRELRPRRSCKSVDIAFLPAIHNATGAIRYCIVARESPSRENICVYTRKTKAQCVNHMQRTPARVIIKKVTGLKPGRKYAIQVSASNKGSSVPYNILYVDTNASCKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM09</accession>
    <name>A0A194RM09_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_13877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM09"/>
    <dbReference type="STRING" id="76193.A0A194RM09"/>
    <dbReference type="InParanoid" id="A0A194RM09"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000025">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="599" mass="67657" checksum="3C3A66E14F2B07B5" modified="2016-10-05" version="1">MIITFLLYCLRRLWVNTLYTGTNQKHADCETCGLGLAECVGHYGYIELALPVFHVGYFSSIITILQTICKDCAKVMLPEKLKKSFRRKFNNPELSYLHKKTLRAAVIKKAKTCNKCPYCESLNGIVKKSPTGILKIIHDKYRNKKSTDPIVLNVLKDFSEAKELNKEVAAMINSGLIIELTPLEVLNLFRRIPDEDIPLLGMNVKACRPEDLILTRLPVPPLCIRPSVISDIKAGTNEDDLTMKQSEILLINDVIGRHIASGGKSELLQEDWDYLQLHVALYINSEMSGIPMSMQPKKPGRGLVQRLKGKQGRFRGNLSGKRVDFSSRTVISPDPNLQIQEVGVPVHVAKVLTYPERVFPANIQWLRQLVCNGPDIHPGANYVQQRGLRHKKYLKYGNREKIAHELKCGDIVERHLVDGDVVLFNRQPSLHKLSIMCHRARVQPQRTFRFNECVCTPYNADFDGDEMNMHLPQTEEARAEALILMGNKSNLVTPRNGELLIAATQDFITGGYLITQRDTFLTKAEAQQLASCLLAGPDSTMRIDMPPPAILKPRVLWTGKQIFSLIMKPNKQCEVKANLEVKGKNYTSKRDMCVQDSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN16</accession>
    <name>A0A194RN16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN16"/>
    <dbReference type="InParanoid" id="A0A194RN16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="14353" checksum="834B72325F149851" modified="2016-10-05" version="1">MKQSANGNAALLPSAMAIYNDNEWPKQFWFSVGCVAEHYEQHASGLKLSPVQWRWCRERVGAAVLRALCERTGAPPSPAPGTAAPPPPRLANSISQSPVTRRADRTSVTPPHANIQPCGEVKLSNVIPFRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNJ0</accession>
    <name>A0A194RNJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin pyrophosphokinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNJ0"/>
    <dbReference type="FunCoup" id="A0A194RNJ0">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNJ0"/>
    <dbReference type="InParanoid" id="A0A194RNJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase catalytic" evidence="5">
        <location>
            <begin position="57"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="6">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="256" mass="29367" checksum="8A15FE0E16946E13" modified="2016-10-05" version="1">MSTNGILCKRSSCECPQNFMKTQWDITQVMGCNGKNLVEYGVLVLNRPIIQKPDFMKTFWNNASVRITVDGGTCQWDKFLKLLPEEEQQSIQLPDLVTGDFDSITDEILQKYKKKGCKIIHTPDQDHTDFTKALMELNKYCTEHKTEIKHAVAIAQASGRIDQILGNVQTLYLSKHKQLLPSTKVYIMSDDAVSWLLFPGEHIIFIPEDTRKHKRSWCSLVPMGEICDSVTTSGLKWNLGTFIFLFFYQHPIVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNN4</accession>
    <name>A0A194RNN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNN4"/>
    <dbReference type="FunCoup" id="A0A194RNN4">
        <property type="interactions" value="1410"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNN4"/>
    <dbReference type="KEGG" id="pmac:106717822"/>
    <dbReference type="InParanoid" id="A0A194RNN4"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000109">
        <property type="entry name" value="WD repeat domain 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="686"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="889" mass="100045" checksum="BDE24773484C7591" modified="2016-10-05" version="1">MSSKPSSQIFAGSRVLGYVSTHVPFVARFIKRRGETLLCTSVGKWFHTYGCDKFRLLSISGEHPGPITCMSGDNFHVYTASENDIYAWRRGCELKHVYKGHQAPIHKILPFGIHLISIDKNNVLKIFDIKEETEFLELGFDEKDFKISTICHPPTYLNKILLGSQQGKLQIWNVRTSKLVYTFDGWKSPVTVTEPAPAVDVVAIALANGKIILHNLRYNEKVMEFVHDWGKVSCLSFRLDGIPVMVTGSTKGHIVMWNLEEKKVMSQIQSAHSSRVAGLQCLASEPLMVTNSQDNSLKMWIFDMPDGGARLLKIREGLSRPPNLVRHCEPTGENLLAAGRDSSLHIMNTVTETFNKSMGRASHNRKASKKKKRIEVDYLVLPPITKLSSCMQRDKQWDSIASLHDGMYMATTWSYNRICMGEHKLKPPEMDKGVQATCLTVTHCGNFVVIGYSNGQVHKFNMQSGIYRGFYGKEKKAAHKGAIRGVETDLCNQRVFTVGADDKIKFWYFKLATSPFHIMKLEESVNSTKYHRESGLLALANEDFTITLIDVDTMKVVRKFDGHIGKINDIDFDCQSRWLVSSSMDCTICTWDIPSAQLVDIFYVEQPCTSLSMSPTGDYLATTHVGELGVFLWANKLLYERIFLKGIDRSAVDIPKLKLPNSTVEKPEIEDIGIIDLGEPEYKSPEQISRELITLSDQPTSRWLNLLNLDIVKMRNKPKTAITVPKSAPFFLPTIPSLELEFDLEKDKENGDRKLLIPESLSTLSPFAKRLVSCNNPEEYGPCVDKLKTLSPAAIEAEIISMGVDAGGSIEVMEHFLSMVGCMLKTNRDFELAQSYLSLFLKTHTKAISQSKVLLNVLESVEEAATETWSRLQAHLMYNICVVKALKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP94</accession>
    <name>A0A194RP94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP94"/>
    <dbReference type="STRING" id="76193.A0A194RP94"/>
    <dbReference type="InParanoid" id="A0A194RP94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265348" evidence="7">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="196" mass="21215" checksum="092C73C52336E6B8" modified="2016-10-05" version="1">MSADRVSLSWTALLGAILLLLLADRADLEPVLHRVEWSTLLFFAALFVLMEALSRLGLISFVGGMLQQVVLQAQGRARLALAILLILWVSGMISAFVDNIPLTTMMVRVVVAIGSNPAVDLPLPPLIWALLFGACLGGNGTLIGASANVVCAGVAEQHGYRFSFLQFFRVGFPVMIGHLLVASLYLLLCHCVFTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRJ5</accession>
    <name>A0A194RRJ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_07484</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRJ5"/>
    <dbReference type="FunCoup" id="A0A194RRJ5">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRJ5"/>
    <dbReference type="InParanoid" id="A0A194RRJ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="17">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ20019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="579" mass="63726" checksum="66D25B22213DB6A5" modified="2016-10-05" version="1">MTTAWSMGPGTYEVPLSLFAKNRERLAKKLKNDQIVVLQGGDSINHYDTDVEYVFRQESYFTWICGVREPGCYFALDVSTKKGHLFVPRLPDEYEVWMGKLLTCQQFKEIYGIEEVHYVDELQEILKQLNPEVLLTLSGPNTDSGLTAKEAVFEGIDEFKVDNETLFPIIAELRVIKTPEEIEVMRYICKTSSDAHKKVMLYAKPGRMEYQCESVFLDHCYRIGGCRHVSYTCICGSGDNAAVLHYGHAAAPNCKMLQDGDMCLFDMGGNYAGYAADITCSFPANGKFTEDQKLIYEAVLAARDAVFREARPGVKWPDMHLVANRAMLEHLKQGGLLKGDVEDMIAAGVNGVLQPHGLGHLLGLDVHDVGGYLSGCPERPAGPLARLRTARVLLPGMVLTVEPGCYFIPKQVLGCALAEDCVVNSALWRLFDMGGNYAGYAADITCSFPANGKFTEDQKLIYEAVLAARDAVFREARPGVKWPDMHLVANRAMLEHLKQGGLLEGDVEDMIAAGVNGVLQPHGLGHLLGLDVHDVGGYLSGCPERPAGPLARLRTARVLLPGMVLTVEPGCYFIPKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSI1</accession>
    <name>A0A194RSI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Contactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSI1"/>
    <dbReference type="STRING" id="76193.A0A194RSI1"/>
    <dbReference type="InParanoid" id="A0A194RSI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001529">
        <property type="entry name" value="Cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="218"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="327"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="431"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="534"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="669" mass="75079" checksum="3830496BDEAA65CE" modified="2016-10-05" version="1">MYQCEAKNQLKAKYSTGQLRVLSLKPSFKKKPLESETYGSEGGNVTLRCNPEAAPKPTFTWKKDNIVIGAGGKRFITETGNLIIRQLSRDDEGVYTCVAKNQYGSDESRGRLIVLRTPRFLERLPPRITTQVGEVIFLHCNAEIDPILDTAYLWNHNGMRLKDESDMYADRRIKIDGGELTIFDVSLSDVGDYECVVKSAIGRISSHTQLRIEGPPGPPGGLQIMNIGRSSITLEWTDSNSNGRPVTSYVLTGRTQWNSSWTVISDNIGNIIEVDRYNGRKRAIINTALTPGSVYEFRVQAVNALGVGKPSAPSPQFSTLPDKPYQAPANVGGGGGKIGDLTITWTPLPPHLQNGPGIHYKIFWRRNGTEVEFQSLLLKEYGNVGMHVVHVSLNYFYTPYNVKVQALNSLGAGPESEVATIYSAEDMPQVAPQQVYSRSFNSTALNVTWDPIDQSRDRLRGKLIGHRLKYWKQENKEEECIYYLSRTTRNWALIVGLQPDTYYYVKVMAFNSAGEGPESERFLERTFRKAPQKPPASVNVWAVNPSTVRVVWRYVQPTDEEEPLIGYKVRVWEIDQDMSTANDTLVEVEQKLEAYVTNLTPGKSYNLRVLAYSNGGDGRMSSPPITFQMGDYHSDAYGYYVRDAALQHKSIPITALLLLLFIIHICNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAR2</accession>
    <name>A0A0N0PAR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAR2"/>
    <dbReference type="FunCoup" id="A0A0N0PAR2">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAR2"/>
    <dbReference type="KEGG" id="pmac:106718837"/>
    <dbReference type="InParanoid" id="A0A0N0PAR2"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857311" description="alpha-glucosidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="581" mass="66761" checksum="52EF7A572D5523DF" modified="2015-12-09" version="1">MRAIIFLPLFIILSSGNVIKQNDEKELEWWKTTIFYQIYPRSFADSDNDGIGDLNGITSKLEHVKEIGAGAIWLSPIFQSPMYDFGYDIADFYAIHDEYGTMEDFEALLAKADELGLKVILDLVPNHASNESMWFQEALKGNEKYYNYFVWEDGVIDENGNMQPPNNWRSQFRGSAWEYREEVGKYYLHQFVVGQPDLNYRNPDVVEEIKNVIRFWLNKGVAGFRVDAVNCLFEVDKDLYGGKYPDEPLSGRRDVDPGSYDYLAHIYTKDQNETYYMVYDWRDVFEEISAQDGLERVMMTEAYATIQDVVRYYGEGERKGPQMPFNFNLITDVDASSSAADMKHTVDKFLTYKPVDKVSNWVVGNHDNSRMASRYGSSLVDGINMIVLLLPGVAVTYMGEEIGMIDGEVSWEDTVDPSGCNTNDPINYYKSSRDPERTPFHWNAEKNAGFSTAEKTWLPVAQGYETLNVEVQKAAEKSHLKIYQALADLRRDDVFRLGRYDSLALNKDVFVFRRWYKGENYLVLLNMRDKDYTLDLTYFENIHGNVTVVLSSIQSPKDEGDTYPAFAVPVVGFEGLVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB62</accession>
    <name>A0A0N0PB62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461033">
        <property type="protein sequence ID" value="KPJ09965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB62"/>
    <dbReference type="InParanoid" id="A0A0N0PB62"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF102">
        <property type="entry name" value="ZINC FINGER PROTEIN 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="17730" checksum="BA05B49EEE49CD49" modified="2015-12-09" version="1">MENASAAATTACERRCPHEQCGYVATTTSQLIRHRRSHGEIIKTHSCALCPFSSDQASHMRRHARCHAGHKPYACPHCDFLCASLENLRKHVLRSGRHKGLYLYECPHCKYQTNMAAELRTHYVSTHTQKYDVKTALEAVKKHLMKTTSGHKDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBA7</accession>
    <name>A0A0N0PBA7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="KQ460971">
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        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_FYVE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
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        <location>
            <begin position="247"/>
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        </location>
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            <end position="1688"/>
        </location>
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            <begin position="45"/>
            <end position="56"/>
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            <begin position="1385"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ10135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1688" mass="187448" checksum="B47814AA649CF9FC" modified="2015-12-09" version="1">MEKYDISQLTEFPRFESEPNQSGVTTFFNKLWKLPLFSPNETAEETEKASVERKQSDSQADSSNKQSFDDTKTESGSYAVEFEGRSLPNVLQRISSLIALGSGGGTRYADTELARYWMPDDISRECYECAARFGALRRRHHCRVCGQIFCSRCCSQRVPGQIFGCAGGLRVCTYCCNVVLSYLRENDAAGDISPDLRTLQENLQVKFPDNKAADKSGDNFMFARQQEERPEPRADTTESLHDLIRQLAFSLPMQQHRFRLVRYNSVWRGCDVMQWVVDNTSNKTRAQAGAVCQALLSAGHLESVTEPPQFADYALYRPAQHVTQRDTQQADNNNDNGEECGRLVESVSSYCLDLNLGDSSARLTKATKTTESKSSPSSEEDHPILDQSEGGEAATLCRSVEQSGAEHLALLLRQCLARASLAPSWLHVLYPLSRRTTELSILMYRGMPQQISNPTVLLLDCSIAYQRVEGKLTSLEPLLMQEQEYLVRCAARITALRPRVVLVRGGAARGVQDALRAAGVALAAGVRQRALRRAARCARADLVASVDARIATPRLGTAKEFYVKNFSGKTLMVLEGCAEPHLGCCILLRGGSLAELVRVKRVVKFMLLAFYNWKFEKAFLADIEAVLPEPGMSFGDEEAECASETDTNREYERQEKESLFNEPKEEEKPIDIKSEDMANVIDDMEDSNIELFTSNKNDTKSITSEILHDKEVKHIKEDQDSNEEVTKTTGGDKNLSCGVPIRDFSDPLRATLSMDDEVFLPKEEAELKADSHSERWCTDDAVLSMSPNIVIPAPRLPLLVPTPNTPQTPHTPRPKRRPPPRPQHTHVLLKEPHPFIKMAISSPAEDPRLRAALAHYRATGARLANTTHKPECPQYKPSILKPPEIEVEGEGEGEAKGGSGATDPLAPEQHQRLSLLLYSCSDKSANVPDFCVNPCGMSPIQTINTQTPRDRGGGEGEGEAKGGSGATDPLAPEQHQRLSLLLYSCSDKSANVPDFCVNPWIVTMEMYGRHDISLGAFLERHCFDGDHRCPSANCQVPMNRHLRRFVHGEACITITCNTIGHSNVDKTKEDHSREVRVWTRCEKCGATSRGRRLSRAALSLSLAQYMRLRLSATRYVRRALCPHPLHAHAHAFVARLTTACFRYNKISMYDIQLPPDVISINYDTKRMRDNLIAHLNELVLKGHETFSVAAGEGDEKEREYAAFRHHMDLIHLALTSASLHEHVTLTSVVRNLWNVSDNIVTGERMLRDAQDKWSSPLTKNKLQTELNQEDKDVDESSVETAANDSSEIISKDIDKEYNIGTEEDEEKGDKKTVKQILSQLLSSNQQANQNGIILSSGVVPVVVRAGDVGSVIAATLASLTYQKTLRAQRYSTQNEQEDGESNVTGKEKNDGDKTKSSAAKSNEHIEVLLKDGLACRVYFALQFHGLRHAVLAAPGAPGPGAPAPGAPAPPHTCSCHTKEKDGKTVCEVEEGFIRSLAQCVPWAARGGKSGSTFCKTEDDRYVLKEMTKPEWQQFLEFAPHYFSYVNSCRLNKQPSLLARILGVFSVGGSGSGVLVMENVWYGASGLRFDLKGTARPRLPPTSTTPTATPHTSHNAQTVLVDLNLLHLRWERQLYVPAQLCGALWAALGRDTAFLASSGVMDYSLLLGLQEHTLVLGVIGRLYPSPHYLLVTGKRDTYRHIKRRYFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCS2</accession>
    <name>A0A0N0PCS2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium-binding protein p22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_03028</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PCS2"/>
    <dbReference type="InParanoid" id="A0A0N0PCS2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ13932.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8693" checksum="AC4CD55C2BED1A11" modified="2015-12-09" version="1">MYDLDNDGKISRDELLAILHMMVGVNISEEQLTSIAERTIIEADTNNDQMISFEEFCHALERTDVEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">RR48_01401</name>
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        <name type="scientific">Papilio machaon</name>
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            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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            <taxon>Papilionoidea</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="56"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14731" checksum="EB89DDE786837BB0" modified="2015-12-09" version="1">MPSYIAVPADQIAFVDLTAMRSRRLPRQTLEPPLPQALYQENYQPIPIQRYQQQPYGLVPPQPEAPARLLQIQPQEKDSAPAPIAQPSQYAERPPDFGEYVDFGAHTGDNGAFGWYADYPVNNQEESGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD97</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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            </authorList>
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    </dbReference>
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            <dbReference type="EMBL" id="KPJ15991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10331" checksum="C06DD6590A64C849" modified="2015-12-09" version="1">MQVLGLLLPTQGHKNYALMTRLASSAGSADFCFANIFAITTVEVFTCNPRQGAVLYPTALGPSAELSHQHLPTYWKWFTLRQYSGTVALVNRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDA7</accession>
    <name>A0A0N0PDA7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spectrin alpha chain</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Papilio</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113124" checksum="631966CC0F2D01AA" modified="2015-12-09" version="1">MPLHIYRTPKTNFIFDPREGEIRLEQKLPMSWHAFNRTPDFSEIAEYRAVRDFLDDWITSNRTIWSYYYEIRPYMDLNNVVPPFAGMAMMTGQGTLVTFDKQVLTITETGTFLLAKDYRQNNFTVLMQSNAHGQYDLVVLTNKHLIYVDLYREQVSLGPDTPLSLPAVVEDFIVHRQTDLLIVEGQSGLEIQCNLLFRTCKLQVSGWHYASLGGLLGTYNNEQYDERQLPDGTLRADVTQLAAAWRLRPAHSHAGPALRPRPQDNDTQCDKFFRNKVSPLHPCFSVIDAQPLYAECVRGVDACALASAYLELCSQQHVPTHIPDHCVQCTTSQGDVVEEGSFVQLEHPPNSTDVVFVIQAQYCNRNLRKAKNIDLFIEAFDSKLQGNGFSDNRYAVVVYGGSGVYREPRALYVDNQLFADAVDVPRHFDAFYIDKVDSVRNESSCRADAFAALRFASALPLRAAVPRAVILLPCDRCDAAVMSVHMNTQADALVSSGQFDSAGIGSRRAAINERFERVRNLAAHRRARLHEANTLHQFFRDIADEESWIKEKKLLVASDDYGRDLTGVQNLLKKHKRLEAELASHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALALAWAELQALAEERGAKLQQSLAYQQFLAKVDEEEAWISEKQQLVVVSECGDSMAAVQGLLKKHEALEAELAARGDRVRELTADGETLLAAGNLHADALSHRLHALQAKLEKLSALAARRKAALVDNSAYLQLLWKADVVESWIADKETHVRSDEFGRDLSTVQTLLTKQDTFDAGLAAFEHEGIQNITQLKEQLVAGGHEQAAAISKRHGDVLARWQRLLADSAARKQRLLQLQDQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAQSDFAALAALDEQIKSFNVGANPYTWFTMEALEETWRNLRKIIAERDVELSKEAQRQEENDKLRKEFAKHANAFHQWLTETRYRLLGWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDM4</accession>
    <name>A0A0N0PDM4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S6 kinase alpha-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N0PDM4">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDM4"/>
    <dbReference type="InParanoid" id="A0A0N0PDM4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000551">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="244"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="655"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="758"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1312"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1200"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1324"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1347" mass="150922" checksum="CB25328FA6D9A235" modified="2015-12-09" version="1">MATAEMSLPDKKPEHESGYYEGSDQEGSMECGCPSPVSSRNSSHSTKLKRRHSAHKHKKAPQKKLRNEHVNGCMGNGHAGNSVEIVDCSSLPSVKDVNNAVETVPEAGPSSKRSSSVELIGGTVPAPARDSVDWNLVYASKIRKRSKVNLNGASKVDISHFDLLKVLGTGDVILTSVSLKVDISHFDLLKVLGTGANYVKLDIVPGQYGVVGVRARTSSARVRRPPKLARSGARSLPARPYIASDLMSTWYFATYGKVFLVRKRCGVDEGKLYAMKVLKKASIVQKLKTAEHTRTERQVLEAVRACPFLVTLHYAFQTDAKLHLILDYVAGGELFTHLYQREHFHENEVRIYIAEIILALEQLHKLGIIYRDIKLENILLDAEGHIVLTDFGLSKEFCGGESRAYSFCGTIEYMAPEVVRSGSQGHDIERAARASVLLRCRVRNEVAMPILLLVKDPRRRLGGGEGDAEELKRHPFFQDLDWGAVSRREVPAPFVPALSHAADTCNFADEFTRMPPTDSPAQAPRHHDKLFLGYSYVAPSILFSENIISDQIWMQATGQKHDKLKGWVAKAVDWWSVGVLTYELLTGASPFTVEGERNTQQEITKRIVRCSYPVPNEVSPQVQDFIKKLLVKDPRRRLGGGEGDAEELKRHPFFQDLDWGAVSRREVPAPFVPALSHAADTCNFADEFTRMPPTDSPAQAPRHHDKLFLGYSYVAPSILFSENIISDQIWMQATGQKHDKLKGWVAKDSPFFQKYAVDLSTPLLGDGSYSVCRKCIHRQTGKDYAVKIISSQKKDVKQEIELLKACQGCPYIITLHEVFHDSAFTYIVMELASGGELSGHFGAAGVGEQVARRLLTQLALATRHMHARRTVHRDLKPENILLTSSRLHEARVKVVDFGFARRLPDHEDRPRMMTPCFSLPYAAPEVVSCARSSTAPGYGPACDLWSLGVIFYCMLCGKAPFQPVSNKEPVTAFMDRIRTGSFTMDGAVWEDISSDSKRLVRGLLCAESARLSLAELLTALGCSEDSAAFKLADMTKADLYKRRRSKNKQRKSSSDTEGAIEEDDTQETSLLLTINNLKSRMNKNSIEHDVELIRANTQDTPLTEQDPPTYDADEVPTVKPVEKTYAKSRSKLDDYIYIESSQGLDETEVAFPKGSRIKKKESQSPPTKRRRIETRQSKKLNGDAQKPPTPKRGRGRPKKNQPEKRVLRSKSVEKKTRATNESIENDKNTKVTRKRKREETKPVLREKGQNGHSSRTSEETKTRKIVRAKRELPQINIEDNVRMTRSRRRRMEISLSPSQVKSVIPAFSFESDRRVDSVESVNTKGKRKTQSKGKKTPVRTTRATTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE81</accession>
    <name>A0A0N0PE81_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459927">
        <property type="protein sequence ID" value="KPJ19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE81"/>
    <dbReference type="InParanoid" id="A0A0N0PE81"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="14979" checksum="CC4DBF8146454301" modified="2015-12-09" version="1">MRLAFPMCRTFILRAQIAEPTPIKAHIFFYEFRRNVYKRSFIEFHYKLCDFLDQDPYIGKVAAALGVACPIQARRYTLANISINLVDFPNIFPFEKGRINFCFNSTATGESIGEGALYLSFKNEPQNKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEF4</accession>
    <name>A0A0N0PEF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEF4"/>
    <dbReference type="InParanoid" id="A0A0N0PEF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002695">
        <property type="entry name" value="ABC multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="172" mass="18699" checksum="F7394657905583F5" modified="2015-12-09" version="1">MFKLFDRTIAENIAYGDNTRVVAMDEIVKAAKEANVHSFVAALPTGYETRIGARASQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTHSEKVVQEALDRASEGRTCLIIAHRLATIKNADLICVIDKGVVAEMGNHAELMARKGIYARLYELQCGFIEEVDETGESGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEU8</accession>
    <name>A0A0N0PEU8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Perilipin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEU8"/>
    <dbReference type="STRING" id="76193.A0A0N0PEU8"/>
    <dbReference type="InParanoid" id="A0A0N0PEU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47538">
        <property type="entry name" value="PERILIPIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47538:SF1">
        <property type="entry name" value="PERILIPIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="992" mass="102086" checksum="8E38E9BE87F496BA" modified="2015-12-09" version="1">MPVLRRRVPVQSRHTPGTSAECGCTEPLEALSEASVRKRLLCSSVRRRMQSRSQLKRRKRPLMWSRNKPRRLGEMIDGAQQTASQAADAGAFRSIGEKTASLFERKKKDAEQIAAEKAQEAAHVVEEQVKKAGEMIGGAQQNASQAADAGAFRSIGEKTASLFERKKKDAEQIAAEKAQEAAHVVEEQVKKAGEMIGGAQQNASQAADAASNTKNAAIDALDKELSKVSLAAGEAVDAANKAVADGKKVIDTTKDTLATTVDNTKKGAESAYNTTKDTVSSTVEGTKSLAQSAIDTSKSYVGSAKDTVANVAQSTVDTAQKSAYSAFETGKSYATTAKDSVANTVGSTVDTTQKAAQSVLETGKTYATSAKDTVANTVSSAADTTQKTAMSAFETGKLYATSAKDKVSTALSSTVDTAQKTTQSGLDTGKSYATSAQDKVSNALNATVDTTQKTAQSALDTGKAYAATAKDTVAGSVNTTVEGTKSAVHSAVDTSKSYLDSAKESSQISAQNTLDASKSYVTSMFDVGKAYLDTAKDTVQNTIQSTVDTTKNAAQNVVETGKTCVDTTKDTVASTVDTTKKAATAAVDTGFSYIGAAKDTVVNTVTSTVDATKNVAASAIDKSVGFVGAAKDTVVNTVGSTVDATKNFAASAAEKSAAIVGGAKDTVLDTVDTTKNVAASAVDKGVGFVGSAKDSVVNTVASTVDTTKNAAASAVDKGVKTYELLKLLTHTVLDTVDTTKNVAASAVDKGVGFVGSAKDTVVNTVGSTIDATKNVAASAVDKGAAFVGSAKDTVSSSVSNTVDTTKGVASAVVDKGSSFFAGAKEFVQTKIGATEKDEVPTEWNDLDEDTADTINTTVDTAKKAGEEAKAQAVKAAEEAKEKARLAAEAAKKEATRASNAVVEETKKAAEKAATDASNAVHSTVDNTLKRVEDAADQGLKNASNVLDAKIKNADKYLGEKQAALVTNISSAANEAEQGAAGLFSKGLATFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFP2</accession>
    <name>A0A0N0PFP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050090">
        <property type="protein sequence ID" value="KPJ21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFP2"/>
    <dbReference type="InParanoid" id="A0A0N0PFP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="19043" checksum="5E68ACDA7333A117" modified="2015-12-09" version="1">MSNEVGTNVFYLTKTLSMLCVDLVKNRPVTCPDDADDSFKKNCLLFYCENYNSLASAVWCRQPSDPKFYDLVFNKETWCRIIDPQMEYQLPLVESWQKHIMHQFAGVELEDSSCLLSSTSTTRTRTYLRTLSENPEEFDVGMPQDDQVWHTSYRIILLTKRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9T2</accession>
    <name>A0A0N1I9T2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin AQPAn.G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460495">
        <property type="protein sequence ID" value="KPJ14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9T2"/>
    <dbReference type="FunCoup" id="A0A0N1I9T2">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I9T2"/>
    <dbReference type="InParanoid" id="A0A0N1I9T2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF291">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="20972" checksum="81B7BD9F3A0600B7" modified="2015-12-09" version="1">MSNLFCRVFEKVRQYFGAQIESIPMSFVLGFYVSLVVKRWWEQYKLLPWPDTLALFISAGIPGALAVPDNVVGGFGMTLPGPGVKDGQALLVEALITFVLVLVVQGVCDGRRTDLKGSAPLAIGLSITACHAACIPFSGSSMNPARSFGPALVMGDWTSHWVYWVGPIVGGVGAGLVYKFIFWIGKSGESGSYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA76</accession>
    <name>A0A0N1IA76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional repressor p66-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460417">
        <property type="protein sequence ID" value="KPJ14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA76"/>
    <dbReference type="FunCoup" id="A0A0N1IA76">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IA76"/>
    <dbReference type="InParanoid" id="A0A0N1IA76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional repressor p66 coiled-coil MBD2-interaction" evidence="8">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="431"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="646" mass="67791" checksum="26B5D7154DC8DCBC" modified="2015-12-09" version="1">MDVDDSAVDLSVRSLPPELSELRALTASGLTITPAQPPPHGASGKRVLRPRSETRSYAESPDIVLLPAAPPHRKPNLPAPAPFTDVSSKLNASVNESITPSVPVAAPESPREPRDDEDSEDDENDPPLPIAGHTELSSAEIWERERRLRALREKLRSEETRLVLLRKLRQSQQTTGIPPAKDTTTGTALAGSGCVVPPGVTVTPAPPPAHQQNKNSSSGGASITPSVTITPAPPPATQHAQPKASSRSSDDSQTPAQRQAAAKLALRKQLEKTLLQIPPPKPPPPEMNFIPSPSNTDFVYLVGLEHVVDYLTNEERMPRSSVPAVCAQCGCDFTAVWRWERAPAPAARRQDPTFSCAPAARRLCELCVSGNVKRALKAEHTARLKTAFVRALQQEQEIERRLAAPAPSPPPAPPPAHAPAPAHAHAHNTHAAHSSHTSHSSHRTPQMSVSRSSSRTPAPAAAAAPAQQPAAKTSQPSNSSRSANSSETLSRHHSERAREQDVPAKKGKGSSSSTASQGSSSSKQHQQLAAAAAAQMAFEQHSAAAMQALQHQLLRGLSGAAGGGGMSAAAAAAMMQFSPLLYTYQLAMAQASALAGKGGGGGAVGGVGGAGGAAAVAEMQRVAEAQRQYLLDMIPGQHGRNPWTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBM6</accession>
    <name>A0A0N1IBM6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBM6"/>
    <dbReference type="InParanoid" id="A0A0N1IBM6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144122" checksum="A130BA80163CDDEB" modified="2015-12-09" version="1">MKECKKAVLASLLKPLLAAKLEKKEGHCSKCGAGPPPPPPPTLVLMPAGPPPGCLPPPPPPPMVLPLPPPALPSLPPIVLSAPPPLPQQLCLPQPPMILPAPPSPFIFSAPPPPIMLPPPPPAPMFLPPPPAPLCLPPPAPAPLVISLVPPAPPPCSCCPPPPPGLPMTAFMVPPPVPVTLEPKPIELPKCNRVNFMKQFSSYGMMVIFSCNTFLLDQENNNRFYGILYIPSSQNYSKELRPKHFSQWYKWVIVNEIPQFVYNARYDADVVLLRNEKVENIANLNATATVLSQTFYDDVYIHPRDGVATNVWAYWNPTGIQITHGRERILRRLDLKQYPLRIATPLGQYSEDWYNGTFKDYLLDVSMPEHDSGVRCAYAASLLLIEALNAKDVLYPTELWSTEIHNSSMLLMLSYGSADLGGGVLRILPNRITRLDYALPIWPFRVGFTYLSERESSSNMFVVPFTAAVWWTCFGFVLLMTLAQRVTAMKPVEKEGAFMAVLATYLQQDASAVPEGASGRWTFVVVSVFSMLIHAYYTSAIVSDLMSTGRSGPDSLRALADSKYAIASEDYDYMRYLMFDVETNWDELEYLKSKKLTSRFYVDMERGVDLIRRGYTAYHTEYNQLYPYLKTFTDDQLCKLQYVDTIPESVTWVTTTKRGQWLEYLRSKGGWVTEVGLAKRLVSNLRLQPPPCRAALLAERVNKESKPCNSFFALLPKPKSTNSESQSSESTNGNEYTASYDSQYYSPAYLPVMPPSPQVIYVSPSPPPFAYPPPLPPYPAPPTIPTPYYPPQESPPEYPVPVTHYGSPSHAYIPIQYPPPVPPRVPYTPSYPYPTPPYPSSPYPGYPEPAPVTYSHWPYNSYPQPHFAAPEYPQPPIQPPTYQSPPQPPSSYPAPHPQYPRYSELIPISPQYSTLIYADIDIDEHENITEIYPKEVNSQEIKEDWADTIFVPDIDLFPTSSTASMAQVVNSDKSPEDQLEEIKEMATSITNAIQSEMANLLTYALSITNNTEDSNRKKRSIDTPMDSTKLVWRLLKHIKSNNEYQNIAIEKMMSAQEIADKYGIEFTPDTEILSELAIAANEQARELTSILKDACDLKNCTQDTLANTSSECLQNRIHENYTCPIHSFKLSDNDTESNMTSLSIEDIPTNEEYNHVHYVDPYTYNNYNSLYETQIPAPPVSQKQTFYDAVSFNPMEYYGPYCSIDPLSNIPFDDYLEPEPEIVGEEFEETISSKIYVDHEVEPGAATVNHVMTYTIAEKTHYRTPQIENLPQQMQYYFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICN3</accession>
    <name>A0A0N1ICN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01033797">
        <property type="protein sequence ID" value="KPJ21255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICN3"/>
    <dbReference type="STRING" id="76193.A0A0N1ICN3"/>
    <dbReference type="InParanoid" id="A0A0N1ICN3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="86" mass="9932" checksum="CC99186B2F94965E" modified="2015-12-09" version="1" fragment="single">ENEIKILEKRCMEKDREKEEILIEKGGTINRLASELEAAQSRLVSGESARLKEKVLQLTTERNTAREQVKELGKDRVNNLFSTILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICT6</accession>
    <name>A0A0N1ICT6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ459757">
        <property type="protein sequence ID" value="KPJ20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICT6"/>
    <dbReference type="FunCoup" id="A0A0N1ICT6">
        <property type="interactions" value="2069"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICT6"/>
    <dbReference type="InParanoid" id="A0A0N1ICT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="212"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="422"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="635" mass="70488" checksum="69CB1A18DABEC37C" modified="2015-12-09" version="1">MSKEKANIAPPVKRYRRDEKSSESEEEIDNYVPYVPVKERKKQKLLKLGRLGQVAAEAAAETKSSSDNDLDDEASQEEWGRRYNVSLLDQHSELKRLAEARALSAAERQAREEQHILESVAQSKALMGVAELAKGIQYEDPIKTSWRPPRSILDRPPEKNDLIRQQLRILVEGEDVPPPIRTFQHMKFPKGILRGLEEKGIKKPTPIQVQGIPAVLSGRDMIGIAFTGSGKTLSLGVVLYVMVCGALPFDGSTLSDLRNVVLSGKFRIPYFMSQGQCNIAQSSSAHYKSPLNGSKLTLKCEHLIRHMLVVDPEKRLSLRGVARHRWLAAHQPGPGPGVPVYISLSYQVRLNVCRYLCMDEADRMIDMGFEEDVRTIFSYFAGQRQTLLFSATMPRKIQNFARSALVKPVTVNVGRAGAASLNVRQELEPVKAEARTVHLLQCLQKTPPPVLVFAERKQDVDAIHEYLLLKGVEAVAIHGGKDQEERSRAVEAFRRGEKDVLVATDVASKGLDFANIQHVINYDMPEDIENYVHRIGRTGRAGGEGVATTLLGRAADDSVLRDLVHLLREAGQKVPSFLLDMIGEPDVPIADGQGCSYCGGLGHRITECPKLEAVQNKQASNIGRRDYLANTAADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDP4</accession>
    <name>A0A0N1IDP4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-independent phospholipase A2-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460689">
        <property type="protein sequence ID" value="KPJ12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDP4"/>
    <dbReference type="STRING" id="76193.A0A0N1IDP4"/>
    <dbReference type="InParanoid" id="A0A0N1IDP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="35833" checksum="81609FA1A4B6535E" modified="2015-12-09" version="1">MVEAIRGIIAIEILRHLEKLTGSGVGNLDTANQMYHTLSKKMFGNTSIIGGTSRLVWTHSYYDTEAWEKMLRENLRDCTLTECNRYNTPKMALVSCVVSPGSRLAPFLFRTYECGFRVRSVFGGTARAAVWHAVRASAAAPTYFDEFKLDGAVHQDGGIMVNNPTGVGLHEAKLLFGANSVKKGTVISVGTGRALNKHSDYQLMSKGMNKEASSTSWKDKFNKILDSATDTEGVHLILNDLLPPGSYFRFNPPLMEECAMDEINPEKLNNLITDTNAYIRRNQHKFEQAAYMLMRKRSISQKMADYIYHKSQIMGIVQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEU7</accession>
    <name>A0A0N1IEU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposable element Tc3 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01062172">
        <property type="protein sequence ID" value="KPJ21635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEU7"/>
    <dbReference type="InParanoid" id="A0A0N1IEU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="15447" checksum="859B18B05E6D3D16" modified="2015-12-09" version="1">MLRHFFFLQLSEFQGYNSATWFQQDGATCHTSNESLADLKEKFAGKLVSRRGDIPWPPRSPDLTPLDFFLWGYMKSRVYSNNPTSIAQLKANIHGEMAAIPRAMCERVFGNLKTRFEKCLQRDGAHLDDVIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF57</accession>
    <name>A0A0N1IF57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras-related protein Rab-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_04343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF57"/>
    <dbReference type="FunCoup" id="A0A0N1IF57">
        <property type="interactions" value="1375"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IF57"/>
    <dbReference type="InParanoid" id="A0A0N1IF57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="31197" checksum="D086AEA7D8BFD8C0" modified="2015-12-09" version="1">MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQEAFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLVFMETSAKTAANVEEAFINTAKEIYEKIQEGVFDINNEVTSAVHFHFFDLESRREVKKEEGEAFAREHGLVFMETSAKTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHSTGGGAGSAGGAGAGAAGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF77</accession>
    <name>A0A0N1IF77_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF77"/>
    <dbReference type="InParanoid" id="A0A0N1IF77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="378" mass="44232" checksum="DC231FAB458F15D1" modified="2015-12-09" version="1">MCVSFNQLMAFYIAPQCYVARDRGVSGQFYECIAWTLISLNKVFIECKEKSNAILAAKWAMNYALRTDSNFRLLCMCYGNMISLCTQERDCGKWQESGEYRTGLGGNAHDEQHHGSQNASAARALDPEAVARRNQAETWYYYYAMVILLDTGHSVESYKSCERFYLKKGDAILRSKTSEAAWNFFVCMWLVTIRVGIWEKSIMWEDKIKQLVTKKYENHEFCAMILVRLIEGLLISMVQEIDNRNVRKIQMYAKLVKSLFRDLNSACKQARMYQPRYYLLLAYYNCISDKKSRAFRKLSMATQLCKQHHNTALLIWIDHTRNHWNGTLKPILVNYWTEHINVDHQMGYRELDTTKGEQIIPYTLPLPKDMPNYNNFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH10</accession>
    <name>A0A0N1IH10_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH10"/>
    <dbReference type="STRING" id="76193.A0A0N1IH10"/>
    <dbReference type="InParanoid" id="A0A0N1IH10"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="4">
        <location>
            <begin position="497"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="69564" checksum="D3288DEB355C7807" modified="2015-12-09" version="1">MDPQELVPLEAGLANRPRPTRQFSQLPSRACYQGPIRLCRLLVLMIVLPCMFIFIPLYMRYKVFSGQMYPMSMTDMRLIDSKISPTWCQRQVVKSNATFNAFVVPGPPSLSDELVPVSMTRELELEDDMKEYWGFYLLKGSSVTVSTCVRKQMIKGYKHLKECAYIGDNSSEELDELLEAYNLGLLSNTTLLEKVQELKKVDGKANDPGTMKRHKAGVSFHDPMQRGNMTSSDPVPSVDVTDHDPKELREILERLHAIRQAAKDEQLKYYRPPSHLMALTELHRHRDTNVDRDTRQWLSFKDIDGNVSDQEVAKNKSLEKTLHSNNTAEVKETPDIKSTTEQYEITTKINNSIETTNTIVVTEKYESPTNIKMDTENEKNQLNTDTDVSSKEIFEDVLKQLQALGDRGKKVLYKLHKTMGVDYQEKGLTPDGYAEHHSQVNETTAFDMSNSEFWSSFSSSEEALLECQGLLLNLPLTPHARCSPGDDHPEAARANALTYRVPANGYYFFVFNSENEVQRNFIRARFELQKTRYDVARTTLRECTNTTDRCDLTLDIFSAQKVVLEVPLRNNDSLWNEQFVIVSECEPRTAVYLACVIAVPILILVFAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHN8</accession>
    <name>A0A0N1IHN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable multidrug resistance-associated protein lethal(2)03659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01003249">
        <property type="protein sequence ID" value="KPJ20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHN8"/>
    <dbReference type="STRING" id="76193.A0A0N1IHN8"/>
    <dbReference type="InParanoid" id="A0A0N1IHN8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="28985" checksum="E34371A04D5E3BD6" modified="2015-12-09" version="1">MSIHSVSSVDNLTAAGMPEGGREAAELRSAGAVSGAVYAAYLRAAGHPLLVALTLAVTTLAQLLGSSSDWWTSYWVTLEEGLPPGLLNALSENATGSTLQLTDNETNPLLDNAQFPNSTLDRYDCIYIYTAMVLSLVAVSLLRSFMFFSMAMSASTRLHNNMFAAITRAPMRFFIPQYSVVTRRHSKRRHANDSIGLSLIGIVVVVATVNWWLLVPTLAIGVIFYGLRIIYLSSSRSIKRLEGVSKSSSLFANALHILLSMVPLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIG7</accession>
    <name>A0A0N1IIG7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIG7"/>
    <dbReference type="KEGG" id="pmac:106714833"/>
    <dbReference type="InParanoid" id="A0A0N1IIG7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="51062" checksum="BFA04892D6F51BD7" modified="2015-12-09" version="1">MPIVNIPAISYGTTIGWMSPNTLLLQSKDSPTEVPLTDIEISWMASLPYLLCVPANYLVAYIGDRYGRKLSIIFMSTMCAACWILKLSSYNIWAFLVARCFAGIVMAASCVNCPVYTKEVCDSNIRGALGCMLALFFTTGSLFAYIIGDIFSYRTVLWICLSLPLFHLITFTLMPESPSYLVKIGKEEEAAKALSWLRRRSKNHYTIQNELEAIKKEQKNDIDGDKFLLKAILKDKILFKAFQIALMAALAREVCGAVPVLNFAGGIFSMASEGTGLILSPNQQAMMLGVVQLTGSLLASSVVEKVGRKVLMAGTCLISGLSMFGLASWFLARDYSYFAPAWIPVFTLCLCILCDASGLQPISVVITGEIFSFKYRGSVLATTMAIASLADFLQLLYFKPMASSIGVHYAFYFFSFMCISSALYTIIVVPETKGRDLEAIYDDLRGKKRKEKNKDIATISNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKR8</accession>
    <name>A0A0N1IKR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-dependent kinase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01022890">
        <property type="protein sequence ID" value="KPJ21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKR8"/>
    <dbReference type="FunCoup" id="A0A0N1IKR8">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IKR8"/>
    <dbReference type="InParanoid" id="A0A0N1IKR8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000646">
        <property type="entry name" value="Cyclin dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="22663" checksum="0D189B0D4E33A9BA" modified="2015-12-09" version="1" fragment="single">RAKDKLNGNIVALKKVRMDVEKDGLPLSGLREIQVLMACRHENIVQLKEVLVGRSLESIFLSMEYCEQDLASLLDNMSSPFTESQVKCLMLQVLKGLKYLHSNFIVHRDLKVSNLLLTDKGSDFGLARWLGAPARSATPRVVTLWYRAPELLLQSPKQTPALDMWAAGCILGELLANKPLLPGRTEIEQLELIVDLLGKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP47</accession>
    <name>A0A0N1IP47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP47"/>
    <dbReference type="FunCoup" id="A0A0N1IP47">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP47"/>
    <dbReference type="InParanoid" id="A0A0N1IP47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="42"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="381" mass="41242" checksum="EA0E9E66BEB849F9" modified="2015-12-09" version="1" fragment="single">RLREVLEDRLQEIKKAKTWKHERVLTSPQDTKVKVKGAEGQFLNFCANNYLGLSNHPEVVEAAREGLKNYGAGLSSVRFICGTQTIHKELEERLSKFHGREDTILYGSCFDANAGLFESMLTQEDAVFSDALNHASIIDGIRLCKAQKFRYPHRDLNELEHLLAHSEARLKLIVTDGVFSMDGTVAPIKGLRSLADKYRALLAVDDSHATGFFGDTGRGTEEYCGVVGAADIICSTLGKAVSGAAGGYTTGPRELITLLRNVSRPYLFSNAPPPPVVAAALKRLRENTREFRAGLQAAGLTVAGDDHPICPVMVGEAPLAVDLATGMLERGIYVVAFSYPVVPKGGARVRVQISAAHAPQDIKQAVDAFADVARSVGIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPY8</accession>
    <name>A0A0N1IPY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPY8"/>
    <dbReference type="InParanoid" id="A0A0N1IPY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="53" mass="5689" checksum="BD946D489BA84AED" modified="2015-12-09" version="1">MEELKKDVESAKVLSAHKTFLENVTDLGILKKKAMSIGASEEAATNLVVNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ90</accession>
    <name>A0A0N1IQ90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459910">
        <property type="protein sequence ID" value="KPJ19339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ90"/>
    <dbReference type="FunCoup" id="A0A0N1IQ90">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ90"/>
    <dbReference type="InParanoid" id="A0A0N1IQ90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="455" mass="48891" checksum="E4566966E9B23705" modified="2015-12-09" version="1">MEPPTDEGDKDGGALEAKMSLLNGITVIVGSIIGSGIFVSPTGVLKHTGSVNASLLVWIASGIFSMIGAYCYAELGTMIKLSGADYAYIMETFGPFAAFIRLWIELLLTFVNCWSVRAATRVQDWFTYAKLLALFIIIAAGVYQLCRGKVEHFTFEGTTSDVTSIALSFYSGLFAYNGWNYLNFIIEELKDPVKNLPRAIAISVALVTIVYTFTNVAFYTTLSPNEVLGSAAVAVTFAERLFGWFALCIPLFVAASTFGAVNGVLLTSSRLFYAGAAQGQMPSALTMVSARATPAHAVLAVALLSLLYLTVSDIYALINYVGFATWLSIGAAVLCLPVLRYTRPDLERPIRVNLFFPVIYIICTILVVAVPAVASPAETGVGCLMILTAVPVYLLLLAPRTRIKALGSLTGSSTRLMQKLTLSVRPKIKYHLLATLASANASTSTLCSVAFGRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQT8</accession>
    <name>A0A0N1IQT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-coumarate--CoA ligase-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01038043">
        <property type="protein sequence ID" value="KPJ21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQT8"/>
    <dbReference type="STRING" id="76193.A0A0N1IQT8"/>
    <dbReference type="InParanoid" id="A0A0N1IQT8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="8779" checksum="D90CEEFF44127DC5" modified="2015-12-09" version="1">MDVCLKVAPAELEALLLQHPGVAECGVVGKPDEAAGELPTAFVVRLPGSDVTETDIVQYVAGKVQFFTFITNQYLYKLCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGK6</accession>
    <name>A0A0N1PGK6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Out at first protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGK6"/>
    <dbReference type="InParanoid" id="A0A0N1PGK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026315">
        <property type="entry name" value="Oaf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053897">
        <property type="entry name" value="Oaf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053894">
        <property type="entry name" value="OAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423">
        <property type="entry name" value="OUT AT FIRST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423:SF2">
        <property type="entry name" value="OUT AT FIRST PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22873">
        <property type="entry name" value="OAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14941">
        <property type="entry name" value="OAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Out at first protein BRICHOS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Out at first C-terminal" evidence="3">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="26325" checksum="65C0A1CC7D9971A3" modified="2015-12-09" version="1">MQENITANVSEDTVILDFLRLDGVYVSQLVDFTNEVEAMKVVIPAEEELGQSGYQTLCFLTHAAQADFIAPDAMAKLRQKNPGTVRVAEEDKGWRQTTTTAWAGRAAWLLSPAAARHCSPARDHVYLRTADLSRWAPRPGMSQLSYSAEVTPFPANALSPDTSDGKPGVSPCVAENDSAKECICHIEVCVNWYPCGLKYCKGKPQGGMSYRCGIKTCHRCYRYHYYVPRRDACLSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI59</accession>
    <name>A0A0N1PI59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI59"/>
    <dbReference type="FunCoup" id="A0A0N1PI59">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PI59"/>
    <dbReference type="InParanoid" id="A0A0N1PI59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18292">
        <property type="entry name" value="BTB_POZ_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056184">
        <property type="entry name" value="TRAF_BTBD17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23651">
        <property type="entry name" value="TRAF_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="454" mass="51486" checksum="11FDEC66BCBC1BFF" modified="2015-12-09" version="1">MSSHSRDLASCASNSEISDENINNNDDLEVDNSKCVLLKIATLYAEQLMSDLILDVGGVAYPVHRLILCASSEVFQVMLMNREWSECKKTRIVLQENPVAASVFPQFLKYFYTGQIKISHKTVLPVLSLADKYNISDLMTLCLEYMGQHVAQAAQRGQLIAWMQYTMACGHNKVAKACQNFFKWNLEWNWLDSELDELEGETLAQLLQQNDLVVHNEMSVYNLTMYRDGLLVGQYERVWEVQQTAGGRALFTPRLYTEDTWGSVLAVDNFHSLPCYHMRTFIFSTRPALADIAHTDRMMEWTVDLYPKGVWFRKSMLIAWSGTYDVPEAVLRTVRIAITCLSVTAPDPYRPEPDVRVKMVLTVKENIMMLHISVKKFNDMCEVNSHLTVVDFDLVTPNLGRCPKCVESNASTEPSHLMGPNKDQLRVQVVILPLTDYCYVSPAEVAAGSDRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI65</accession>
    <name>A0A0N1PI65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01014112">
        <property type="protein sequence ID" value="KPJ21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI65"/>
    <dbReference type="STRING" id="76193.A0A0N1PI65"/>
    <dbReference type="InParanoid" id="A0A0N1PI65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="95" mass="10573" checksum="6A80F5D13B03224F" modified="2015-12-09" version="1">MAKKSKVQKKKASSVTEQKVVQETNKVGYSNICLLVTSIIALLVGLACFQFYVNVIAVPNLPAIDLNEWWGTNTTKPKDTSIRPFRVLYIDSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ37</accession>
    <name>A0A0N1PJ37_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ37"/>
    <dbReference type="FunCoup" id="A0A0N1PJ37">
        <property type="interactions" value="1319"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ37"/>
    <dbReference type="KEGG" id="pmac:106711276"/>
    <dbReference type="InParanoid" id="A0A0N1PJ37"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="582" mass="67107" checksum="C1B83A184A2170DB" modified="2015-12-09" version="1">MEEIIDKFNVLTAKPVKYLSVQDDVKGDVKNLIKTLYGFTKSEEEDIKQKNKALPHLLVDDFDEEQIWQQVELQNSQCWDQLVWEVANCVSNKTDLTFPVTIAEQNVSTDTDELKSQSKSKATKKSKAKKATKKQKDVKKKSKTKESIVDDDFFKLKDMEKFLLKEERDDGKKKDSDEESIDFFDDIDDGSGDVEGNEKDIKYSDFFDGDENDDGEDDNIDNDDNYDNGEKNDEELLDEMDENESEIEEKDLSKSGEKKVRFADQPESSSSDDESETEDKTNEINKSKNKLDTEEKKSEFEKRQQRLQQQISRLEEKTLKEAPWQLKGEVDASKRPQNSLLEEVVDFDLTTRPPPIITEQTTITLEEIIQRRVKDKAWDDVEKKEKPVDDQLVFRKPVVLDHSKSKLSLAQVYEAEYLKQKHGEPDNNEENEPQEHKELREAMDKLFSKLDALCNYHYTPKPPQAEVKIVGNTPAISMEEVAPVATSDAALLAPEEVKKKRKGDLVSKDERTQTDKKRERRKKKKLQRLKGDVTKVTDNRNTKKGVEANDKSIKTSKAFFQQLNDDSTSVIKLKAKRKNKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJX3</accession>
    <name>A0A0N1PJX3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJX3"/>
    <dbReference type="InParanoid" id="A0A0N1PJX3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="12716" checksum="61314DCF866CB4C6" modified="2015-12-09" version="1">MIRAQRHCGWRTRGSACGARGGDAVCGGAALSSAPLCPRPATRSASVLRSRCSSHNRALRVSVLSAQCSGCVDVSEARCVRTSRVSCARCAGEGSMSPLALLLPLLAAALLAANQIEDIPHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKE6</accession>
    <name>A0A0N1PKE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01045441">
        <property type="protein sequence ID" value="KPJ21436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKE6"/>
    <dbReference type="STRING" id="76193.A0A0N1PKE6"/>
    <dbReference type="InParanoid" id="A0A0N1PKE6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10936" checksum="18D20EF749FFF9FC" modified="2015-12-09" version="1">MCDVISIVKTPTQEFEYVQVGANASSKKWMQQYRQCASYFNKLAKDDLLRFLNDTCFSSDAVKRVPAGTRNLMLMQAVDYCQQEQENDYKFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLA1</accession>
    <name>A0A194QLA1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLA1"/>
    <dbReference type="FunCoup" id="A0A194QLA1">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLA1"/>
    <dbReference type="KEGG" id="pmac:106719892"/>
    <dbReference type="InParanoid" id="A0A194QLA1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF535">
        <property type="entry name" value="GH08870P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="468" mass="51199" checksum="85C3AAE088EB2E31" modified="2016-10-05" version="1">MSEERVKMRKQLGLLEGVAIILGIIFGSGIFISPKEVLEKTGSVWGALTVWGVCGVLATLGAMSYAELGTTLAQSGGDYHYINEAFGPLPAFLYLWDANLIFVPSTNAIMALTFANNILEPIFPNCSIDPWSKKLIAAVTICFLTFINAYDVKFTTRVQNIFMFTKISALIVIIIGGIVWMARGKVEHFQDGWAGTKTSVSDWSVAFYSGIFSYSGWNYLNFMTEELREPFVNLPRAIYISLPMVTGIYLLANLSYLAVLGPVGVRATDAIAVDFAIASLGWLRWCMPALVAIAVLGGLSVHVMTSSRMCFAGARNGHMPELLAHINVACMSPLPSLIFLMLISLIMLIPDSLTSLITYCTVVESFFTTLSCSAVLWLRYKKPHLPRPIKVALWMPSVFVCASAALLVVPAWSEPAAVAAGALITLTGVPAYLLLVRHPPQRLQTISTKFTHTCQKLFLSAVEDDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLM1</accession>
    <name>A0A194QLM1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLM1"/>
    <dbReference type="InParanoid" id="A0A194QLM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46949" checksum="F1E4FCBFF1559723" modified="2016-10-05" version="1">MNLAPGQAHWHKLLSVRSIERSGHYIADAFERLGRLRKSITQIALENEVLERENGKVLHLIGEPDFRDVRLRWEYGSEEQRQLLAFQVHYCELQAWGQYRCRTKVVENHESEKAGRSRVGDISTTTPSGRRGRAYSAHISGLRMATTYSFEVRPVRRDARDLADPQSIGSKIIIVPTKGFSARATQCLPHASEVEVSTGPYFGGRIAVEAADGGPERCALQGNPRSAQDAYILRIHHRECGSEVNDTTVATYVIVQENLPILTHSTRRFLVLCTYKPETLTVRAGINLPKADPGDVLHQTKPIGSVEPYDNQDMDYNDLQPARLEARKEESQQSAFGEVLLVMFLVVAAFGGIALLIWKMVPQTDKDNVSITTMSSMRSSIFGRRNRDRFSDRSSVYSITLSEKEGTKKSNEGDNTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM07</accession>
    <name>A0A194QM07_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FDX-ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM07"/>
    <dbReference type="FunCoup" id="A0A194QM07">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QM07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264469" description="FDX-ACB domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="3">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="27628" checksum="7AAE03F968BCDCB0" modified="2016-10-05" version="1">MAQFLFQVLYSFMIVTIVLGNSLGELQKSYADLVMECAKEFPITPEDIAQLQNKQLPEKEPVKCLLACTYKKAGMNYLLLIGYLGIEVVNEAEVSDGTKGCDRAALMFRCSIDKADESLNDAEVKAAFTKTVLQCTKEFPVDMKELLQLQALKVPKKQQTKCLLACAYKKIKTFNDKGMYVLDEGYKFAELSKNGDEQRLINGRKLAEMCSVVNDMEVTDGDKGCDRAAFFFKCFTENGQKLGFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QME5</accession>
    <name>A0A194QME5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QME5"/>
    <dbReference type="KEGG" id="pmac:106719617"/>
    <dbReference type="InParanoid" id="A0A194QME5"/>
    <dbReference type="OrthoDB" id="6998938at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264478" description="Apolipoprotein D" evidence="1">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22758" checksum="D13C6411E01D28A2" modified="2016-10-05" version="1">MAHILRLSILVIVYLYIVAAKSYDKQPNCQEFSKNVTFKDSEAIGIWHLLHFKTEKTKGSGESHCVQFTNVGEQEKKDLQERIGQYVENMNWDKLLIKMQIPCSSVKSNKTRDYYLEKLEGDGSYRTLQMPSPTAKLDLAQFHRYPMRLKLVEGQYLAMMDCHEKFVFLLGKQPPTADLDDRIKKMIDAYWPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMY9</accession>
    <name>A0A194QMY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear hormone receptor FTZ-F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMY9"/>
    <dbReference type="STRING" id="76193.A0A194QMY9"/>
    <dbReference type="InParanoid" id="A0A194QMY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ06335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="26806" checksum="2B3D4463959D6E80" modified="2016-10-05" version="1">MDQQSGLMSLNMSAFDLSPGPDGSGSGGGPSSASQQYVPQGAAYQCAPDQQPFGYANLDTSYLFPTGTGEPGAYLPAAATVCDQTDTKDVIEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERACHIDKTQRKRCPFCRFQKCLDVGMKLEGESYKLYGIYIHKLLCRFVYLHRYQNHNSFGNVGRMQARLQSAAEMALHHAAAASAEKLKVWLRIETAVCNPPATFQQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN80</accession>
    <name>A0A194QN80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN80"/>
    <dbReference type="FunCoup" id="A0A194QN80">
        <property type="interactions" value="1886"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QN80"/>
    <dbReference type="InParanoid" id="A0A194QN80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="24970" checksum="5777873B4D99BE82" modified="2016-10-05" version="1">MHAQLRELNRGKQRKTRKIVEKRFAKMKKIISPSDPRIKAKDRAEPKKKKAIDPHEMKIREVPQTSSALFFQYNTQLGPPYHILIDTNFINFSIKNKLDIIQNMMDCLYAKCIPYITDCVLGELEKLGRKYRVALRIIKDPRFERIACLHKGTYADDCIVQRVTQHKCYIVATNDKDLKRRIRKIPGVPIMYVAEHKFTIERMPDAYGAPKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNM3</accession>
    <name>A0A194QNM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Short spindle protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QNM3">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNM3"/>
    <dbReference type="InParanoid" id="A0A194QNM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000002">
        <property type="entry name" value="Patronin, isoform M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="184"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="10">
        <location>
            <begin position="1479"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="970"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1264"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="810"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1419"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1620" mass="179955" checksum="87B530A2C81CFDD1" modified="2016-10-05" version="1">MVAMVASASGYGTLRRFLSAPDCQGVDVGEVAITSSVAVSSKQRASIKWLLSKAFNNRVPENLQEPFYRDHEDQEHLKPPIVGGLANAELYCLALANMYSDPNYHSLSHWNILQTLARKGVPVPDPADCALTETVLIQTNPLKMSAHMCVMEALMVLYAREVVTGDRVAAAVQRFGFSQQSAITGHEDGLLTWINAACAALNNAEDESSSKVPPLRSLQEACDGAALAALISFYCPEALPRSAVRVGRMSSIHDCLHNLMLVRDFCRDRLPHDVFHMMPEDVAYMRGSMRQNLVAMLADLFNLLEVHPVKSVKYPGIARADSNAHGVRHKRCLPPPPPTPIPDLRADAHAHAHAANTPLPVSRSPSASGVRGRAAGRSACSTPERRSMSPQREEFVVHRGRAITTLSALVRREEENAYSPYPGVGVAGVAAGRPSSRGPRESFAGRRSRRSSISDDSQLTVENFGGSQDRLHFAGRNPEKELATVTSAAAMTHQRKISAPAGPIDYNPPLRSSRQDIRGSIQFFHEDYQNGQEERNKMERQHSQPQTTEQYHPIRRQLSSDTITVNQTHGMSYKGGGDGYYLNDRDSTDGDGSKTSFADLNKIRSNGDQQGLVKMKGEGEPERRKTTTFSTPPPNTTTWQQHFMQQEHQPNGDEVLDEATSPSGGQAMAAQLNNIRLKLEEKRRRIEQEKLRMEVAVTRRSQQLGQQAFLQAVTRLATHSVTYYTNSMFYAAHVRCVRAQSTGVRTRVRGWLSACACAPYASCLLRWRCTGVLQGKGARTPADDDGKDEHHNRQDMVVEPPGQSAENVALEQYQQSIAKMNSSLQDIQSDIARLASQQSQLQQQQQQQHQQQQQQQLQQQQQQLQQQQQQQLQQQQQHLQQQLQLHQQQAKQLFQQPPPQSPYQQQFQQNIPQLHSQFSSAHNVSRANTTPGFGSTPHIARDLYTFEPDDQPQFYLHDTPAHPPRRTWAQHAQHAQHAHHENTELRGWQPPPERTWHPQGFVLHDRTNQPFPVHYNNDRYQNGTENIRETQNHLSYTVINPSHYVSQSPPPAASPQRRSNTPQRQGSLPEVSRRPEPVSLQQLQAPAPAPAPVPVQPPDDMEPQNISFIGNAEDDALRQGINRLNISSGTRTYRIPSPTRPSLNRTSFQHMEQEESEQNEKGFYISFDNEQPKRPKPPLRAKTSYQIVSRRQRADEARARAEAAAAARRAREEAAQEQKLARKEEQARRREAILQQYKLKKAIEEAEREGKVLDKSEFMETLKGGHSQAGVGGAGGGTRLRGKAARARPKTIHVDSGALHAAEGMLAKQPSATNLSAGGTMRRDYYRGSQDSLAERAGLYRESPVEDRGGVSPGSASSGALGRRGSCKTSRERVNDEAQSARGRSKYSTYQSNFKAGRKSSSLMNLCDNVGGFPDSGLGRATPPRRAASPALRARGAGSPASGPGSLPAPPTAIGRRRAPPDDASDVSSTHSSIMDYSGPKLYKQPTTKSNRGIMLNAVEYCVFPGAVNAEAKRRVLEEVARSESKHFLVLFRDAGCQFRALYSYCPDTELVAKLYGTGPKHVNDRMFDKFFKYNSGSKCFSQVHTKHLTVTIDAFTIHNSLWQGKKVQLPSKKDMALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPJ2</accession>
    <name>A0A194QPJ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPJ2"/>
    <dbReference type="FunCoup" id="A0A194QPJ2">
        <property type="interactions" value="1796"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPJ2"/>
    <dbReference type="KEGG" id="pmac:106718952"/>
    <dbReference type="InParanoid" id="A0A194QPJ2"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000030">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="374" mass="41758" checksum="1D02B420EA488ED6" modified="2016-10-05" version="1">MSQTLTFGDSCAPITCHAWNKDRTQIAFSPNNNEVHIYQKEGNEWKQTNNLVEHDLRVMGIDWAPNTNRIVTCSVDRNAYVWTQGDDGKWTTTLVLLRINRAATCVKWSPMENKFAVGSGARLISICYFEKENNWWVSKHIKKPIRSTVTTLDWHPNNMLLVAGSADFKVRVFSAYIKDIEDQPGPNVWGSKLPLGQLLAEFPNSPSGGGWVHSVSFSADGNKVAWVGHDSSISIADATQGKSMIKIKTEYLPFLGCNWISNNSLLVAGHSCIPLLYCHDGNELRFVAKLDNTQRKESGGLSAMKKFQSLDRQARIETSDTYLDSIHQNAITCISLYKGTKANAKKFSTSGLDGQLVIWDLDSLERSIEGLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQZ1</accession>
    <name>A0A194QQZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase TRIM37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQZ1"/>
    <dbReference type="STRING" id="76193.A0A194QQZ1"/>
    <dbReference type="InParanoid" id="A0A194QQZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19779">
        <property type="entry name" value="Bbox2_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03773">
        <property type="entry name" value="MATH_TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16619">
        <property type="entry name" value="mRING-HC-C4C4_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037299">
        <property type="entry name" value="TRIM37_MATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
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        <source>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    <sequence length="1125" mass="121798" checksum="D9B316934CC84ABC" modified="2016-10-05" version="1">MASRGDKGNGNGEEQIVETLAEVFRCFICMEKLVDAHLCPHCSKLCCYACVRRWLTEQRSQCPHCRAALHLHELVNCRWVEEVTQQIETMQQSNSASQRESFRDSGDGPAILPAERTADGAAKYWNGDHEQVDAAWAKWIDDLVKVAGVSWMRVAQDISSWRSLGEAQQCPTHQEKLTVYCWTCRRCICHQCALWGGTHSGHTFKPLEEVYEQHVTQIRDEVSQLRRRLMELISLVQDVERNVESVRAAKDERVREIRNAVELMISRLDSALKAKLLTLMGQKNSLTQETEQLEHLLQEIEHQLHSSTRSELIAKSGELSKMIHQVRKKPMASFVTAPVPADFHRQNYVHTLQIKDYHGVAFFEFAEIVPSYDSSTFPLSNFTQLQHAAAPVYSAPLHVNGLCWRLKVYPDGNGVVRGNYLSVFLELSAGLPETSKYEYRVEMLHQVSRDPSKNIVREFASDFEVGECWGYNRFFRLDLLASEGYLNPEADTLILRFQVRPPTFYQRCRDQQWYINQLVTLQNQHILQINDLKERLSLEMSRNSIAATRAPNTSIPSQGNNDDNPAQNNSVDGSALNDSLLYGNQWKFNTSQSIINGQRLTSPAGILNTSLFLDDTTRNNDVSSQSGYGFGDYAPLERRLHSHTHAHAQHALDAYNLPSTSRSASSLAAGSGTAVGGAGGGGADSMALVSLHTLLSAARPPARLPRHDKLRAPAQPGTPALPAKDTALTAVASSPVTVATSSPALCASMSSPELNSAGAKSEAALEPPPDAAESPNATQSPHVASETSSDTGELMFTELESLTEDINPNNVDENSNEENDVDEETMSDGSSGSGSCEWCALGDSPGRGRGGRGVACGRAAYRRVRSRPKPYAPRCTPGENDVEGACGVSPEAGADALSRLLCAVHGRAVTPAGSDGSNPPPAPSAPAPADPQLSTAAHTDMLLLNLMRINGLTPKHSKHGPKRSWATSVQSAEPGHSGGSRSQRRGSSAAGAVSSGAGAGARPRARQTRAPPLSPGQLRRTHVPLPNGRACSGAGTAGSPEARARLKRYTTTGAPSPPSATRTTLSLESGGAECEEPPPVQPWSPAATRDTPAPHAPHAPHAPHAPHAPHAPHAPHAPHAPPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR26</accession>
    <name>A0A194QR26_PAPMA</name>
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        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264565" description="Lipoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20442" checksum="938544F2D03360D5" modified="2016-10-05" version="1">MFRVILLSLFLYSFGTCYPRFFETKHFKVGIEYDRSLPMSGGSDRYRHRNNYDPFFVTVTASAKKGYVMSYLEVSATTDALAEVTFELIRGKTGSRNMVFQLVSNHSDFLAYSYMAYGIREEEYKKVTNIVSLPIQNHSFATSFNCYYSFDNFNVPLEIPGLSPAALEDGNKEALVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRZ0</accession>
    <name>A0A194QRZ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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    <dbReference type="KEGG" id="pmac:106718759"/>
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    <dbReference type="OrthoDB" id="1915375at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35455">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16029">
        <property type="entry name" value="DUF4787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264580" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="114" mass="13421" checksum="3F7600749ED6EC9E" modified="2016-10-05" version="1">MLRMALLWIIYINFELYKSYACEPSAVPFTFKEYPYKDTPKNEMTFREFETACEQSSACSHMNGLARTRCIRECVSPSCYRELYLNDPLEEGEIDVRLNSFKGCFIQRSGRTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSD3</accession>
    <name>A0A194QSD3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium channel protein Nach</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_12186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSD3"/>
    <dbReference type="FunCoup" id="A0A194QSD3">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106717707"/>
    <dbReference type="InParanoid" id="A0A194QSD3"/>
    <dbReference type="OrthoDB" id="8062007at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF253">
        <property type="entry name" value="PICKPOCKET 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="575" mass="66544" checksum="10EC23A0DBCB4809" modified="2016-10-05" version="1">MQSNSHPSPFASTYRRDKRRLAKQTDLEILKESVKTVGRDYCAESSISGLKHLVNDNTSFLERVIWIITMISALICSVSLVYLTFRKYYRAPLVTTQMPAGVSVSKIIFPAVGICSNNRISKRAITELARKLVKEERNKMYDEEGMLSLLVGLGMLYNIDPMDDEVVKPMQLHRALGVYDVNELMRNLTPRCEDLLLRCAWNDEPKNCSKLFDFRLTMNGYCCTFNYLRRSDGMFKDTTEISRSIDMYKYGNKSSFDFDQGLKILMRLNGSDDFYYNRPLQGAQLQFSDAYDFPDAPSGSFSMQIISPNVQMTVLVTASFTEASRDIQHVPVKLRQCLFYDESQYLSFYTHSDCMLKCRMSFLLANCNCTPFNMPKMLNTRTCDMRDVPCLRIYNAQSITVRPNVYQIPFELEMNIVDGGINCPMCYPTCSKTAYNYDFTNVRIYPDYLNSVPDNDRVDWLRGANFTGTSIVHVKYGREVADCYGQNVIMKWFDLISNIGSTCGFVTGFSFVSAMEFVYFFTVKLWREIKKRRREKNMAALGSSRHDTIKRYPSLYWNELVGPSRWKYDSKMFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSJ7</accession>
    <name>A0A194QSJ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-AMP-activated protein kinase subunit gamma-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSJ7"/>
    <dbReference type="STRING" id="76193.A0A194QSJ7"/>
    <dbReference type="KEGG" id="pmac:106719823"/>
    <dbReference type="InParanoid" id="A0A194QSJ7"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="450"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="524"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="686" mass="78238" checksum="0980ADC007E32DEE" modified="2016-10-05" version="1">MDPILENESATPESPSKHEKNKHKHRKKRHQSETQKDGQTVVGEKKKFVVTTLSSSDEKETTPERLPNANVHTIHFGTRGVESQRPHVRTIFKDKPVESSRPSSAERDSNQKEYETFHGTSSSPRSSIFDIFRLRRKSDSKKHQAVIQNVKASTSKSTDTDDSSKEEKPVDPKDSHKKYYHTVTGASSRKFSPITRVMDIFRNKPHTEHNQSPADAAKKKNSKQIRRSSIETTSPTYHKNSYASLEPAQAKQLFREVRGLPKYDPYLSIVQISIGGRDKTRLLLNFFKYHKCYEILPKSAKVIIFDTQFSVKKTFLTLVSHGIRSAPLWDANKKMLVGMITVTDFIRILLHLDSENLSMEDLERHTLHNWKKILRPTRKPLCAVGPDQSLHEAINLLTKNRVHRLLMIDPFTGDVLYILSHKRILRFLFVYLNEFPELTFFQKRLLDLKIGTYDEILSVTENTTIKEAFKLLLEKDVSALAILDDNGTLIDVYAKYEVLNLVSEKLYLNLSLTIGEVRNKKKDWEEKLQKCRSSITLYEALEVIVRTESHRLLLVNKDDKLIGIVSLSDILLYLNRIIPTEKKVSSLQEIFRPLEENKLPESLKESENEVISIEVPNLAAKIVPEANEATTKSNIAIDGISTDVTSANVLETDVEGSNNKTIHNSISRTPSESLPLADNINNNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSR5</accession>
    <name>A0A194QSR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase ULK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSR5"/>
    <dbReference type="FunCoup" id="A0A194QSR5">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSR5"/>
    <dbReference type="InParanoid" id="A0A194QSR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000493">
        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="589" mass="63608" checksum="BEB60F14032D2510" modified="2016-10-05" version="1">MNPSKQDAVFILSESIANISYLEIYRSIVDAGDISTYCNGGDLADYLQANRLLSEGTIRLFLRQLAEAMRAIHAKGIVHRDLKPQNILLTHNVAPPRTPHPAEITLKIADFGFARFLEEGNMAVTLCGSPMYMAPEVIMSLKYDAKADLWSLGTIVYQCLTGKAPFQATTPHELKAFYENSVDLQPKMPAGTSPELCNLLIGLLRRNPRERMPFEMFFNHPFLQRPRTASATSLDMDLPDILECVMEGQVDINCYLEESWDSQGIQHLHYCFGRMGRSRRAVRYGRYGGGGVGEVVWGVEAARFPAPRSPLPAPQPVTHTLTKAPVSSAESSDTTWAGEDDFVVVEATESGSAECSGHSTHSSGSEAAPRPRSLALTPASPGAPAAPSASDTPSSPTSPASSSPPDHPAPLRNPMTVASKVPRSQPIDVLRSNNNRNTTNIGSLSPPSVPFTMGTPPSTRRRSASGSSPPPSLWQVSPTNASPLRRSGSSPPVSLALKASGEAASPKRGALPDALLRGLKLHQPEPPVYIPNLQEDTILAEEHSKVFSQLNFVLMLAELLSDLAVSCGAPIAALMDTSDGEHIYLFHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSS5</accession>
    <name>A0A194QSS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSS5"/>
    <dbReference type="InParanoid" id="A0A194QSS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="16248" checksum="093AA83591F2A2C5" modified="2016-10-05" version="1">MAVVAFNLYQLGLAVISKDDNELEAKFSNFDKLENIFGDGKKDLVRLTVKIYYLTYAVIGVLLFLFASLFTCGAYKVNNCLVTTFFVYSFFHLFFTIGLIVWEAITAGWIQLGLILLSDFEVLKFPPFYALKSKHDGSVKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT13</accession>
    <name>A0A194QT13_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_12212</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT13"/>
    <dbReference type="STRING" id="76193.A0A194QT13"/>
    <dbReference type="KEGG" id="pmac:106717945"/>
    <dbReference type="InParanoid" id="A0A194QT13"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="58994" checksum="577EE04AAF8E25B6" modified="2016-10-05" version="1">MDIITQNKILSYILDEWKILLFLVAIYLLYYYGTYNYDYFEKKGISYIKPTIFVGSLWMRVTKQISYQNYQLYVYNYFKGKPFGGIFLGRRPTLFLIDPDLIKAVTTRDFEYFVDRNSLETNEPRFLKRTLLNLKGSQWKAVRSSITPSFSSSRLKNMIPLIQQSSDQMVKFLQQYDKSDVEMKDLVGHLTLEVIGACAFGIKTDALTDENAHFVKLAKQFGDITTKRKIFLLIFIMFMPNLMKYFNLSFLNTEAIEELVKVLKVTKAERRKAESKKRDFLQQIIEAADKEREEVEKTGGVIQLDEDTIDGQSFLFLIAGYETSSTLLSFGIHILAVNPDLQNKLREHILQVTEGKEITYDLLTELDYLEGFLLETLRLHPPLSRVDRVCVKDYILPGTNVKLEAGQVVAIPVYGVHMDPDIYPEPSEFRPERFMGEERKNRPSHLYLAFGAGPRNCIGMRFAMISAKIAMVSLLKNFKFSPCAKTENPVTIDMDSVLLKPAAGLWVKIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTH2</accession>
    <name>A0A194QTH2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTH2"/>
    <dbReference type="InParanoid" id="A0A194QTH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="53" mass="6188" checksum="0166DA5754BCE207" modified="2016-10-05" version="1">MQAALMLRAKSRERRKQRLKRGIKAELPSNVATKTIAPFPRYPPTSWVCHSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTZ0</accession>
    <name>A0A194QTZ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nostrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_15139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTZ0"/>
    <dbReference type="FunCoup" id="A0A194QTZ0">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QTZ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11823">
        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035656">
        <property type="entry name" value="Nostrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="115"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="676"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="737" mass="82929" checksum="B071323502F5553A" modified="2016-10-05" version="1">MPLNITGIKLTILVGGGKGKRTKIRSPAPHSSDETRHCFHFTPIFSVVVVFHRTFSSSSKENSNIGNATASNKGEKDGSASAMNRENVSTKIAAGMDRWQNTFEEMIHLRSSNNQAFKDNYWAQNGFDELRRYVKQGSDFSKELAAILQERVEAENYYSKCLAKLGTKLTKACKESVGSCAEAWKHVAIEMEKRSEIHRNYSSAMSEELVKPMKHFIESQLKLRKKIEGNVDKTTRTLTDWRTAEAKSKRQSHAAARENEKLQDATLDISRMSRSSSVGHIPHSILSAARAERLTNNTSERDAAKLQVKKRKTEDAVKKTEVDYYNVCVQAERARLEWETSVVKGAGMLESLEEERLAQLKISADCYLRLTAAVPSQLAEATNALVGPIKNANANVDMRVVRGVRSSPAGASEQLLPDFYCEHTTLAMNRERRKQALLKILQLVKQDIDRERKSKQGLEKLSMAIKQTPTFGGDDSQQNVADKLFHMRSMLTYLEAVRYKISASLSELDSRSPVQHPLATHIQIVRDKQGLQQSILKVPPWLQKDYQDEVNRNLQPNYTALLKSVNGGEERERRDSIMSRASSKLRIEHLSFRKNTEIKSAPTTPVCPEPPKPMKVPEFQAPPPPESPLDWSERGAGDGLSNQHDSDFDEFSSQSGSSTDLNELEKNGNNDETAQKYIGRCRALYTYEARMDDELTLAPGDVINIYDKQDDVWWTGDLNGNYGIFPSSYVEEITTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV76</accession>
    <name>A0A194QV76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV76"/>
    <dbReference type="STRING" id="76193.A0A194QV76"/>
    <dbReference type="InParanoid" id="A0A194QV76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19678" checksum="BCC220CE7F61B0D4" modified="2016-10-05" version="1" fragment="single">PPEIVYLPRCIEIRDSKLHWRSLDGDKLPANAIIGGFQNDPIYIARAKHRGSLCPGKYIHSQRCAYIAWGFSEHRKDKFEILCGLNVRWVKCKGKNIPENAFIGGTSEVNNEPLYIGRAKYGSDLICGKVHLLYGTCYLPYNGSELEYKSYEILVIPDIPSRSIQDSQHCCVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVZ2</accession>
    <name>A0A194QVZ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proton-coupled folate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVZ2"/>
    <dbReference type="InParanoid" id="A0A194QVZ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="554" mass="61476" checksum="5F7C3641524FAC59" modified="2016-10-05" version="1">MTLRVEVPGDKIVTVESCKCNKNYCTDVAKNESKFTRRLKEIIKNTWDTRNKITVEPYVICYVLPSVLAGLAVQNLCLEKSCLVNLKYDERTCTSIMQGRTHNYTEQEKSVQTMVAGMTAWSFPLQTALPGLMTLFVGAWSDRTGNRKAFMVLPIVGKLVSVFGLMLSLAFFLQVGLNETALIEGLPPALAGGRVAMTMAVYSYITDVTSDSERTYRLGIITAILTLTRPIGLALSGIMTKRFGYYGVFTIACVFYLSGFVYIVLRLKEKPKKSIDNDNSNTIFSLFSIKDLSATINVAFKRREGSRRLQIILIMLAYMFIVGPVLASEHIIIFYDCILLASRVKIADAHGLGSLTNRCVIWNKGEAQMTYWFTRYKFKFTEVDYSLFLTYSVLVGSVGSFITLYLFSKKWEIEDSAIGVFACLSRVAASVVYALAPTRTVYFLGPVLDMFSSAGATSLRSIATKLVDADEVGKTSSLISISEALVPVIYTPVYSKVYLSTLSTFAGAFYLISAALAVPAIGIFLTLFSLRRKEIKESSTASTNKSKENEVTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW87</accession>
    <name>A0A194QW87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 18a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW87"/>
    <dbReference type="FunCoup" id="A0A194QW87">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW87"/>
    <dbReference type="KEGG" id="pmac:106718533"/>
    <dbReference type="InParanoid" id="A0A194QW87"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000070">
        <property type="entry name" value="cytochrome P450 18a1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF413">
        <property type="entry name" value="CYTOCHROME P450 18A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="538" mass="61423" checksum="0964E4770655EE06" modified="2016-10-05" version="1">MLSIFTNSRILWGLWQLVCYSSTRATLPLVLGVVLVYLTAWLLVLIRETRKLPPGPWAPPIVGYLPFLGVRHKTFLSLARNYGPLFSARLGNQLIVVLCDYKLIREAFRREEFTGRPSTPLMHTLDGLGIINSEGRLWKNQRRFLHEKLREFGMSYMGNGKKIMESRIKSEVYELITNLQLTEGAPVDANPLLALGVSNVICGITMSVRFSHGDLRFERLNHLIEEGMRLFGEIHYGEYIPLYNYLPGKALAQEKVARNREEMFAFYQTLINEHRNTLDLDNARDLIDVYLIEIEKAKNEGREGELFEGRDHELQIKQILSDLFSAGMETIKSSLLWMIVFMLRNPEVKRRVQEELDSVIGSDRIITAEDMPDLVYTESTILETLRMSSIVPLATTHSPTKDVYLNGYRIPAGSQVVPLINCVHMDPTLWEEPKKFNPSRFIDEAGRIKRPEFFMPFGVGRRMCLGDVLARMEMFMFFATIMHQFDIQMEAGAAPPSLEGTVGATISPQSFSVRFLPRLINAANLTPDHPHLRHVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXZ9</accession>
    <name>A0A194QXZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dynein intermediate chain 2, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXZ9"/>
    <dbReference type="FunCoup" id="A0A194QXZ9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXZ9"/>
    <dbReference type="InParanoid" id="A0A194QXZ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="562" mass="63171" checksum="F116A5FFF7236B77" modified="2016-10-05" version="1">MDINYQYSKKRGDFGRQPLFCEQGPQLCDSIAPDLAERRRYILRNPVHQFTQNTPSFSQHTINTIRAEYTNSGANHAEGGWPKDVNVTDPEATQRYRRKIEKDDNYIHCVMALSPGMEHYVLQNNAIDMYRSYYAEMAEAPPLERSSVRIVNICRETTHPPRRVRAICWHPDGGHQLAASYTYIDWDRRPLAPVHSLLWDTTSPQEPLLSVAAAGDAIMDMAYAPRAPHMLAAALLSGRVGVWDPRAGSAPVVLCPPHIAHRDMARRLLFIHSKSGQEFFSSGPDGVCKWWDMRNLNEVTDELIIDMVKSPTEPQNMATAFGASALEYEATIPSRFMVGTENGLIIGGNRKGKTAYEKLPARFDAHLGPVWSLERNPGFLKNFLSVGDWTARVWSEDCRESAILWTPPARHRYTAGAWSPTRLSLMLLVQFNGVLTCWDLLRRQQRPVLSAQLCPEPLLSIRMHETGTLAACGSQLGNIYVVEMSHNLAQTDKNDKALLTAMFERESKRERILESRLRELRLKQRQPAAGGASALALTTPAADLAAVTAQYAQTVRRELANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY85</accession>
    <name>A0A194QY85_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY85"/>
    <dbReference type="InParanoid" id="A0A194QY85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045839" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="10507" checksum="C96DB05738C29B2F" modified="2016-10-05" version="1">MKYFAVFALLAVASAAVLPPSVVVNAQSPLVQIILKINVPTNVPGSPVVVETVPPAPTPVQVVEEAEVPEPVIVVDQPVVAEPVIVAPVLPAPVVVLPDILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYE4</accession>
    <name>A0A194QYE4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYE4"/>
    <dbReference type="STRING" id="76193.A0A194QYE4"/>
    <dbReference type="KEGG" id="pmac:106715912"/>
    <dbReference type="InParanoid" id="A0A194QYE4"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="17221" checksum="1C0BB1949F0B6CDE" modified="2016-10-05" version="1">MTSSIIRIAARITKCRPITACSRHHQYSTENKARYYTKKHEWVAVNGDIGTVGISQYAQEALGEVVFVQLPDVGKEVSAGEECGALESVKAASEIFSPISGTVTEKNDKAESTPSLINKSCYEDGWLFRLKLVGTEELKKLMDQTAYDKYLQESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYG6</accession>
    <name>A0A194QYG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cysteine proteinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYG6"/>
    <dbReference type="FunCoup" id="A0A194QYG6">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYG6"/>
    <dbReference type="InParanoid" id="A0A194QYG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.170">
        <property type="entry name" value="Cysteine proteinases. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018602871" evidence="7">
        <location>
            <begin position="17"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="531" mass="60161" checksum="53C84887EBE4C1A2" modified="2016-10-05" version="1">MLLKSLLFLFVGTALGYVDKQSPPQWSNVYTVKGLLVIPYAELHEPFYAWLDHKPGVAPVTTEKELNKETCLQVNGTEDQNVSIQSVLPDMTDFKFVGTETMQDADTSKWRMVQTIGDKVNKYTMWVKYKKSLRGDPLPIPVRYEMKGFNSLLGSHYDHYYLDYRDYNVEDIDPNVFDVDRNMKCTSFPGPGSRHFATFNPMKEFVHPVHNAHVDNEFDRFKTKHNKKYASEIEHVKRLNIFRQNLRYIHSNNRARRGFTLAVNHLADWAEDELAALRGRRYSGPSPLGLQFPYGVSELEEMSVKLPPEFDWRLFGAVTPVKDQSVCGSCWSFGTVGAVEGALFLHNGGHLVRLSQQTLIDCSWGYGNNGCDGGEDFRAYQWIMKHGLPTEEDYGDYLGQIDELDHAVLAVGYGVLNGQKYWLVKNSWSNLWGNDGYVLMSSRDNNCGKQNLYPSIHSASLRPLLGIGHPQRSPRGSVLCNPHPGYSRNLDQIILREACPRCADLYVAAIPVLCGPIGRPFCGQYGRPIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYJ3</accession>
    <name>A0A194QYJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYJ3"/>
    <dbReference type="InParanoid" id="A0A194QYJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF71">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="38641" checksum="1AC9D1C342FF9AC2" modified="2016-10-05" version="1">MTWLPKIGEGPLWKNRMVLEQERCLSSWWANILYINNYIKTDEICMFQSWYLSVDTQLFFVAPIFIYSLWRWRRIGSVFLALATFISLAIPSYITYRDQLDPTLLFYAKEFTDFATNFYFKEAYIKTHMKMTPYFMGLITGYILHRIQSENYKMSRLVKIFGWLTSIVLGTVAVFSVSVFYQEWYKYNKIEAAAYVSLHKLAWSIANGWLIIACCTGNGGILNKLLTWKVFVPISRLTFCAYLVNGIVELYYVSQLRHPLHVTFFTMVANSIAHLVLTFNLAVILCVIFESPIHGIERILLRIFARPALSDNARRDISAESSRNTSQSKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ47</accession>
    <name>A0A194QZ47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 29</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein intersex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ47"/>
    <dbReference type="FunCoup" id="A0A194QZ47">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ47"/>
    <dbReference type="InParanoid" id="A0A194QZ47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021018">
        <property type="entry name" value="Mediator_Med29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11568">
        <property type="entry name" value="Med29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="19873" checksum="8525F6273DD9BC3E" modified="2016-10-05" version="1">MNTGGGQPNVGMQMPVAGPIMQQPSPQQMQPAMSQQTQQDKMDNISKVKTLMGSLRESLTMSLKTGAQILHQNHCIDSNPQKSLDNPVPRFDKNLEEFFSICDQMELHLRTAMTCIQQAQSAAHYLPLTVNTSRLDSGPPTQDTQLTYPQYLNTVRLQISYAKDIHDTLVAAAQNISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZI0</accession>
    <name>A0A194QZI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_15142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZI0"/>
    <dbReference type="FunCoup" id="A0A194QZI0">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZI0"/>
    <dbReference type="KEGG" id="pmac:106717122"/>
    <dbReference type="InParanoid" id="A0A194QZI0"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="223" mass="25038" checksum="B8A7AA20ED108D75" modified="2016-10-05" version="1">MLHLGDVFPNFTADTTQGEINFYEWLDQSWGILFSHPSDFTPVCTTELARVVTLVPEFKKRNVKVIGLSCDTIESHNDWCKDIQCYAGCNENEPFPYPIIDDKARNLAVKLGMVDKDELDSSGIPLTARAVYIIDPKKKFRLSILYPATTGRNFDEILRVLDSLQLTDKAKVATPVDWKLGDDCMVLPTVPEENIDTLFPQGVTVVPLPSGKKYLKKTPCPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R060</accession>
    <name>A0A194R060_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R060"/>
    <dbReference type="InParanoid" id="A0A194R060"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF17">
        <property type="entry name" value="OTOANCORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15107" checksum="3EDF59590CD2B61D" modified="2016-10-05" version="1">MIQHFGLDYNLSDEQLSAIADRVRKDFASKEPEDYTVYDLKALRNILCGFNASDIRKIHPSAYKEASYEIGQLKCKTDVMKAFASLAIHKKAYGPAENWTDSTIKIIGEVKKYLPKNIITGKNLYEQIINTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0A5</accession>
    <name>A0A194R0A5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pancreatic lipase-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0A5"/>
    <dbReference type="InParanoid" id="A0A194R0A5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="34421" checksum="31F1E9F612DB1CC0" modified="2016-10-05" version="1">MADSEDGPETPRVLLLRLLHTAIANEQRSGSANRYFVYTRGNFNDPREIIVNDLTTITESGVELIRDTVIIVHGHKSTAFNSLNPTVKNAYLQNFDVNVIVVDWSTVARLDYKLSVANVPGVGTAVGDLISLLLDANRVDLRRIHIVGFNLGAHVAGFAGKRLQGQVARITGLDPSGKQWNMNSGRLSASDAQYVEVIHTDSEGLFANGLRDAIGDVDFYPNGGSKQPGCGLSSSCSHNRAWELFAATLRVDNELSGNSCSTFSQLSWNRCNGDPLAMGDHQFSKPGSGIYRIDMLILIIKERRLKKHLNQNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0L3</accession>
    <name>A0A194R0L3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger matrin-type protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0L3"/>
    <dbReference type="FunCoup" id="A0A194R0L3">
        <property type="interactions" value="1118"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0L3"/>
    <dbReference type="InParanoid" id="A0A194R0L3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000282">
        <property type="entry name" value="Zinc finger, matrin-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="260" mass="30752" checksum="54AE8ED5ABDFC3F3" modified="2016-10-05" version="1">MSMRPDDHRRKWDKDEFERIATERLKAELEEEEERDKKKAPPVKRELLKQRDYKVDLDSKLGKSVVITKNTPTSQSGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMKIERSTLDQVKARFSLNKRKLEEKKRDYELDTRLREAAEEEARLKELRRERRRDKKRKIQETEDPDDTPAQSELAQIMGFSGFGEYQVTAAEDENWMGDTLQETRVKRQLEDFDSDDATPDDQEPGFWDRVVKVALRLFNKFIEWLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0L4</accession>
    <name>A0A194R0L4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0L4"/>
    <dbReference type="InParanoid" id="A0A194R0L4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="714" mass="82350" checksum="E78693A3B7051DFB" modified="2016-10-05" version="1">MVPNGNVSGVNIHNGSNLRNTHQMYLNNQHNVQNDQNTYRPLDLSSFARNNNNHEPILRQQQQNIKIPSYNPSLLPHRPPLNKVPNQIPNVHVLLPNKRVDNFYNSGNQFAVTLPKNYYVQNNLKREVNRYRNRPENFKVTPVQPVVEHKDVERTTTGLLENKNGKILVPATVQPVSRVPHIDVNKELLNKLTPQLNNIQRSVINDALDRQKPTINHQNVFSQGNIQPQRTLQNPRNNLQTNHYPQNKRFTVIHDNGYVEYFDNLETILRKYPHPQRTLQNPRNNLQKNHYPQNKRFTVIHDNGYVEYFDNLDTILRKYPHVRITDNILKLIPNRNHNIPQSKPLTHNSDSNAKIKNNLPLEQHPNLFNKNVPPQTMLHTSKRTQNPKIETPKEYPKNIQKKDTSLMNKSNDNFGTLQTSTSLPIKVDNKKSEKLQSSNKPMKLQDNKEMNFIKNITTAENIVKIQSTDVSNKNNKTTTLKNRIPSDGNKQKPPIDVILNSEQKISHQENKTNTSPVISNNKYEHSENVTKLQEDLHLNKSKEVKTPIVIQNKTENKTVNTYESKPEIINKSSLNNDTVDKINGTQSNCTKQNEVKNKLKAQRVDEINQKDKGEKDVDYDEDLLSLVKPVMWFSTTDPEFWKKLVSVDENPNFIYIINVQSQPKIEKDRKTMIHANGTIVEEITETIWDAGDDEPPKITKTIKVTPANAVSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R138</accession>
    <name>A0A194R138_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spliceosome-associated protein CWC27 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_10145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R138">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R138"/>
    <dbReference type="InParanoid" id="A0A194R138"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22288">
        <property type="entry name" value="CWC27_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
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    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
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        <property type="entry name" value="Pan_app"/>
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        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
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        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
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        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
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        <property type="entry name" value="PAN_1"/>
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    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
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    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="15">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
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    <feature type="domain" description="Apple" evidence="16">
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            <begin position="517"/>
            <end position="600"/>
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    <sequence length="2781" mass="314271" checksum="79FB82230F98E665" modified="2016-10-05" version="1">MSNIYIQEPPALGKVLLKTSVGEIDVELWTKEAPKACRNFLQLCMEGYYNGTIFHRVVPGFIVQGGDPNGDGTGGESIYGEPFKDEFHSRLRFNRRGLVAMANAGKDDNGSQFFFTLGATPELQNKHTIFGKVTGETIYNMLKLAEGLIGPDERPEHPHKITSTTVLINPFTDIVPRVTAVKIEEPPKKKKKERIGVKLTCTNFFTELELEEESMKEEMSNKDLEKKKEETVVAVNNIRDKLSSKKRGKSPENESNKRRKEDDNDKESSAEEEYYLGKERDMERLKERDRIRNEIRQLKKEMKDTKEDNIKAEDLKEEKKPEKSIEDNEMYKQFVEEQEKYKKIKEKIPKKGAARSRRTKFTRKTTRKKPWVKNLYENRDYPDNYTDRKFLEELRKNLFVEKVTLKQAVQGSFRVVLRLCLCVMYAVLEDFTLQLLAKFKNKLHAIKEKNQTENETIKEDDENFNTPDWMGHTLRFEDKGAVLAKDASNKGDDWFDIYDPRNPLNKRKREKSDRKNCFERISIGEHLPRDAIYRNISELTTKECEQICKQDKQCQSYDYGVGAKGNATCNLSTISEKDIKDKSVLGRHPDYDVYVRRFQCEQSPPTPIQAEFDDPDGLLHRPTFKPASDPKKPLSDEVLDDLGSYSNSDTSKKPAYNNERPDDYDNLKPDYDSPPSYGLHKPQDVPYPTENPQINMSNTRPDPYDVLQFQDQYGRPRPQGTWRPEEMYGHRPDDFGPDPYRPEIPQYQYIIRPNRKPHQSSRPENDDGYGNKPDYNGKPDSYGQNIPSTSLDRPYKPNKPSNTYPSRPNDKPNYSYNSQYASNYGSQYHDNSIYLEIYDPPRTYKPPSKPNRPGYGINQGDYEYGHLGYGYDTFTSQNSYSHLQNSQSQYYGSGILNQDNSYRPDPEYSLKPTKPYDIQDVGYGSQSSSNQNSGGYGLLSTSKPKPNKKPSYGGYGTQGATDSYGSSGYGSGGSGYYSNSQSFVGSENYESNSQSHYSSSHIQNEKPQNSNHGYGGDSQSNQAPYGGSSQASNKKPYKGQGYGSNNQNYGADQASYGFNNNEYGGGQTTNRPYGSGQGYGSNSQSHYGSNQGSYGDKYGSHHEYGSSNHNKPGYSDGSSNDKPYSSSLGYGSSSHSNQGAYGETSHSSNIPYGGSQGYDSSSSSYGSSKPQGSNSVYGNNNKKPSGVSTSYGDGYESSSGYNSNHASYGGTQYEISQGYGGQNTYDGNSNSYGGTHHSNKPYGGSTSSRPYGPNEGYNDRPVYGSNTEGNGNYGGQTHSSGYNARPSHKPDRPSSSHSYTSQHNSQYQSQNSFESSSSYNRPIDDGGYRKPGNQSSYGNGYDRDRLNVKPVYEYEIDRPGEASGYGKPNGDVITTRPVAVGDYTGKPNYGRDPGGEISYKDRWMDEWMDVCLKVSPIASTILSAVKNTDSACVSLPTYSHVESMAWSTLPMLREHWLDPAFRGKGLCELMTKPIEAFDLRRDFVEDKDYDFYELDRNSLEPNCPDTLRGPGLLHSGFLSNKRPGHDVDRWKDRIDWYDRSSQSEYERHYNERRRVVNSNRRYQNEVFVPYQIGVSRSDEDSETGRQYGGAYGGHNYYKDKTDYRKSFNHWQISDEAHRSNYYGVKSHSLNSDFNYNSLRKDSGWENSGYGYGAWKRGRWNNSWNGYDYGESDHYKYNKPPVYYELDRMDGLPAKDCSSRRRPGMSLGTGAIRRSLFARNVVECEAACFGEKEFKCVSYSYRYSNGRGSDNCFLSERPYRGLDMSADSDSDVYAMPQDQGCATVSRTPWVESECFWHVRSESAVAGSAARASLTVTGLGACEAECIRAHAFFCRGFSFRFDSPKIGDDLENCILTSSPPTSLEIGHGLRTTAGHELYARGNYGRGCEPALYDDVQHKDTECFLKYDNAAKLKGTAVRGLARVKDEQECGRACTDAPFTCLSFSFTKKAPQGRDNCLLSEIRLFDLQRGVDYEPSTDDWLFAFDLFNERCWRKVHGKQEYDTPSFELPHPIAPSEYPPSGPTGHDHSGPSGPSYPSASGPSGPDFKPGYPTGPEPPINKPGHSAPSGPGHKPSYSPGYVPDTAPSGPSGPDYKPYIPSSPGYIEPYAPTFKPAYPPPTYKPVIPLPPRKPLPIPPSGSDYRPAYPPSPPSGPGYKPIYRPIEPNRPPLPPKPEHRPGSSRPGYEGDREENGGLLMSWRQYTVSGFPCRRGTTCAQNHIAGHWACEPEGGEIGSWDYCCAPTHRCGYSEGFKKPWCYVGPTHEQWRPCSEKYYPYFKHKVPHPSQGQREPSPSQVSGQWRDRSGNIPQSEERPGPYLADADRSYWDNLYKNGPRAYYDKHGNPLPGYTRVPTEERPRIKYHHNQPQPGNGTWVPVPDLGGFDNRVVPEPLGAPRYWPVAYLHKGPPPNMTYFRYNETDHTSYDRSQSRESEDGIALPTERSINEFKRVDVIRPKGTDIEGRKIKDEPTDNKTDVDENILEFENDTTTTTSTTTTSTTTTTTTTTTTPKSNSYKSNNDSEVINNLTDTNTTEIQISKPDNVDTNEEFDNIKGIDGKLGDFSKSIEVFELEDRSKCDKETDFKTLEAEERQIEAIGRLVASRRGGKLILEKRSQKDLESKNIAVDKDLLEFNFGNKFPTTERRGIIQRVSKDEIDKERFTNDKSLEVSETTFVRPPRILSTTENIRKAIVNGKVFYDATIREQRDLITNATRKAKSLKLDEARGPSVISTNLNTKRKTIQPRNVNPIRKVRRVFRKRYNPEEVRKRLLEREKYLKSSDNKPKVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1B7</accession>
    <name>A0A194R1B7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyadenylate-binding protein-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KPJ11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pmac:106714792"/>
    <dbReference type="InParanoid" id="A0A194R1B7"/>
    <dbReference type="OMA" id="HFCLESE"/>
    <dbReference type="OrthoDB" id="8171816at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="419" mass="46823" checksum="E87A38CE7D956D31" modified="2016-10-05" version="1">MNNGDVGGSRGRGRGWQQNDNQPRELRRPKTVVEVEPSKSKLSADAKEWYPPNYVPQPATYTDPSPYRPQRFSVQSRLRQAQDVNPYSYEEMSYALEEFENVDLRENLGNLITVMCEITFEPGKFDTLCGPLVDSFVSTLHDVNYTRPLVEAIVNQSIAESNFRYNGARLCSMYDSVSPPEESKFRSCLLERCAAEENKIISGVETSEENMRGFAMFLAEIYTQLEDSQGGRLKSLGESLCKVLLHLLDTDKEINIKAVCQLLKLSGIALDADCPTGMHAAFERLRRRSSLACVRGVVALRAARWGLTEPDREPQPPQDSAPPSAQGAHAYDTRRRQPNNIFNGDMEGGANNEGGYLADGHTLTAEECAFLQSNLPSKAAAIEEDILDELENDAWETGMDAEMQAGFLEFLKMSNQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1P2</accession>
    <name>A0A194R1P2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Post-GPI attachment to proteins factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1P2"/>
    <dbReference type="FunCoup" id="A0A194R1P2">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1P2"/>
    <dbReference type="InParanoid" id="A0A194R1P2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="25079" checksum="088146AF9A0FA933" modified="2016-10-05" version="1">MYKDFDRANNTHCNVPNIFPSISASIGNYEPQRTIWKTAIYIHAPIRFFIIYLRWKYYREIILDTFGVIVNVAVSLNVIENFSLVGLTYWTSSLNYPLHEVCFKTFIGTSIFYMLITSIMVTQYRRKSHMTRLERNSVKLKWRAFSINVVSFTIAAYFFLRHNRLCEPYVYSMFGFSEYIVVFSNIAFHMTTVYDLERRYIYLGTRGITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1P7</accession>
    <name>A0A194R1P7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1P7"/>
    <dbReference type="InParanoid" id="A0A194R1P7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443736" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="238"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="471"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="775" mass="90107" checksum="F27F8B22ED768DC6" modified="2016-10-05" version="1">MFFFWLPIFLLTLHSFYVECVIPNLSVNELDKKLIQRKRQDTLDMCRIFNEETARLEQYNSVKKFKTNEDHSKQHIRTKRNVDSLNPTVKVEDIRRVEGIVDKLYDDMDGNGKVTYRQRRFDTTTTDKTELEFFQTFQTFKKFKTNEDHSKQHIRTKRNVDSLNPTVKVEDIRRVEGIVDKLYDDMDGNGKVTYRQRRFDTTTTDKPLLNKTARRFNFAPAELLGPSSKQDGPTHHDEAEKMPWHKKWKQGIVPYFIDPNTYDSQLSDTIIKAFDYFEKASCIRLQRLRERPTDKLSLQNVEWLYITNPYGIKQCVHSNERKANSGVQMVVFGYDCLSLGEIVHEVMHILGYSHEHTRPDRDQYITIMWDNIKPGYKKYFTTRADDPLLTLSYDYASVLHYPARAFSRNGQATVVTNVKLFNIKIGQRDGLSETDIEKIGMVYGHECVERNRQYLLKTCPSVVKVSGESKTATQDEIEKYFEDRLWPYGIINYKMRDKLEFSAEERENIKAVIRHIEKETCIQFRELQDNDEPKQTTAANQNNVDTGSNNTSPIMYSFRPTPEISDNEIKYNDETATKTIITKADDIGDLTSASTKPSDVVNETSTLPTSRRHAANLLILSRSSEPGCHCPSPGRPNGNKDLKINADCFNSVNELLHLFVHVLGLDHQHNMHDRDSFIHIVWSNLTEEIEEEMQQKLPPAAAAGFPYDYLSVMHYPWLHIKNGVTSIMYPIWNDGWSMGHWQGLSATDVRKLNLIYAAQCSQRKEFENESDDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2I5</accession>
    <name>A0A194R2I5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BORA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2I5"/>
    <dbReference type="STRING" id="76193.A0A194R2I5"/>
    <dbReference type="KEGG" id="pmac:106714824"/>
    <dbReference type="InParanoid" id="A0A194R2I5"/>
    <dbReference type="OrthoDB" id="10020858at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023252">
        <property type="entry name" value="Aurora_borealis_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728:SF2">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15280">
        <property type="entry name" value="BORA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02038">
        <property type="entry name" value="AURORABORA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="686" mass="76872" checksum="A1F279D977C89DE7" modified="2016-10-05" version="1">MNTKNDGSNRDCKFTPPTKPKKVRNPFDKALIERLHKPICSPGMCKIYKKKNNGCFKWDIDQASTLVPADIVACSSQFEPSPDPMLEKIAEEASDRFFSQELVVPSPLETSKKVKPLLKKTPNTSVLENSLNTYVTKKDVSVQTVLSLPKNLPHEVEEILQNFCTFTQDQNVSGDYVITANDSFRRQLFFEEHSDTEHYDSEVTDDEVHHDTRPPSSYETHSPIVISPDLSQDLVTKGLKRTFGTPLNKGNVRNNKACLRNKALDVVDFGEPCFSPIEFRTPKRMDQESATSSSLASASISPVNKPSSDEEKNAFTSPESDTMATCLDCIIPEPERQKQYPCFCKISTNKLSLKRSASLKDSPTKARRGSNLSMEKRSLSMSSLNRSRSVQKLDFSMDMSIDGSIHNCSQEESESGQNQGAQEAWSIVEDSSIKNLVKLELFKEQSCDIQSSTKLDSAKLHILEETPIKGKSKHSVLSHEISKIRSCITTSPSHMSLDNSLDSSENSLSLEDKKIDFNNVDLKFLTDLSQLNYNNKNVTTVGESSCSFKRIDSGFNENTFYANASSYYESAIKPSELTVTETSKNINHSALKEISNVTWMRVDSGFKDETSTDSTQFYTSNENSNLKFTGFRFTEAKLEDKENVDSFVNAMNKNVLSMSDIFTEDMKLNCNSSSTPSKNKSRRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3H6</accession>
    <name>A0A194R3H6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3H6"/>
    <dbReference type="InParanoid" id="A0A194R3H6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264892" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="511" mass="59799" checksum="E898BC880C7BD8F0" modified="2016-10-05" version="1">MADVQFLLLVSATIFIVDGKIINHVRHEVRKFPDDFLFGTATASYQVEGAWNEDGKSESIWDHITHENPCVTKDCLNGDIADDSYHQYKRDVEMMRELGLDYYRFSLSWPRILPTSFPDKINEAGVQYYNNLIDEMLKYNIKPMVTLYHWDLPQKLQEMGGWTNPNIIDWYSDYARVVFELFGDRVKDWITINEPHPVCNFGYGDKTMAPLLNIKGVADYMCAKNLLLAHAKAYHIYDKEFRPTQGGKIFIALSAQWYDAEHEEFSVAAQEANDFLWAIYSHPIFSKTGDFPKSVKETVAAKSAQQGFPRSRLPEFTQEEIDYIRGTSDYFGLNHYFTKYVYRNESVVNYYESPSFEDDYGVIMYTYDDWKIGESDFTKFVPWGFYKLLTKIRQDYDNPPVIITENGFATLGGLNDDDRITYYKHYMNAMLDAMEDGSDVQGYTAWSLMDNFEWLQGYTQRFGLYEVDYESPERTRTPRKSAFVYKQILRTRELDMHYEPDTNVMTIDEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4D9</accession>
    <name>A0A194R4D9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Achaete-scute complex protein T5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194R4D9">
        <property type="interactions" value="8"/>
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    <dbReference type="STRING" id="76193.A0A194R4D9"/>
    <dbReference type="KEGG" id="pmac:106713537"/>
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    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="BHLH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="401" mass="45603" checksum="42591C38CA4C30C1" modified="2016-10-05" version="1">MSSIGVVVFRNSPLGKAQVLQESVNNTVNISNNDANPNIGEIIIVRKKHKITSPNTVSVSSIVRATDSANSNLAKRPRFRENLLEDSSKSPTPLAVARRNARERNRVRQVNDGFAALRRHIPDEVAAAFENANSNRGPNKKLSKVETLRMAVEYIRNLESLLNIGHDKENMSRPSMESFPSPASSSPRENSQERSYFSLNSPAIDDDDIDEDDLDGSLQLQQQSYMEMPSSETFHLVATPHLYDEEECVGQPLTPSSDLLGHEEGNAPMIDGHFPFPNSAEQFSVIPEQNYCSETEIALHDRDFEVKYAQSIHQQMQPDFENETELPLEAINPDLILSQNQYKFKEEDHAFLENQPYNEIELKKELPEIQVTPEDREQFEETLKWWQEKTRQSRPLSKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R695</accession>
    <name>A0A194R695_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R695"/>
    <dbReference type="STRING" id="76193.A0A194R695"/>
    <dbReference type="InParanoid" id="A0A194R695"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="901" mass="100467" checksum="247E1A6BCE6579FF" modified="2016-10-05" version="1">MAQYYQIVGQGPSLTLEDLQRYCPNICLDGIIVNQEDQQFGQQQVVVQQADTSSDIIVSEGVQPQLVVGDGLPYQQQYIIRHEPQQPTRTEFQPQQQQNQQQQQQQQQQQALHRHQVYYTSDLPVDAQVVLQQAQQIIDASLMQQSSPQHPQHLLSFQQLVSPGHVLSQPTVIHPAQQPPPQPPPQAATQQLGPPQNGTPTRQPAPRLLNQALNNTPGLTLVRTPVRTVRPRRPPARPALASPAGAQVARHLNPQLQQAQNSPAGVGRGVSAASPAGGRGGRAARPPASPRVMPPLAQHRPPRPRTPLSQTPHQLAQHIIGQQVHQQQIQQQINQLKLTPQQQQIILNQQNAGISQATRIITPQGTIVTQGLQTQMSQHNVVQNQSNGPLPQQSTMNGPTQRASPHPQIQQQVKKVAVQPNNANEMDDLEESITAAIVQKHPINENISSPQQFHTPPPQNRQNHTSTSVPQHQLTFSPQHFLNSQPQQQTFEQTQLQHSTTLSHLLMDTDNAEEERQVLTFANGQRITLAEYKRLHQPARSQQQLIPQQQSETGRQTLVRSKEQPRPVQRVLPMQNQQQPMHSDTSESVSSGPSEQAAEPQSAKMLIFLQNGEQRLITFTLPKESCTLQEVLEQVNVPFSEDTHIQCMQNTSSEIDYFVSVGATTRIEEMLENHPMLVGDMSSRTSPSTLPQPQNSAMSTPEKSQCPDNVSSNSPESPERRSPPPRYVDGMLAVCKSCGYTGFDFSRCQRCKRVFTEEPKSVPTKKLEQKKKEPEKSLLDKQNSCSSDGIKLNLLKTTVKALNNKTEKKPTRVRKPKAKPDPEPVILTLSSDEEDSNSSMLSSQHEISINIKEPTLSEIEGSSENSFGMDHMDVRILTTAINRNYQRQNGENHIDTKYHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7I2</accession>
    <name>A0A194R7I2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple C2 and transmembrane domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7I2"/>
    <dbReference type="InParanoid" id="A0A194R7I2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="183"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="575" mass="66683" checksum="98BCD1BC5537F69D" modified="2016-10-05" version="1">MDPLAPTALAVSSDFMDRIGSGLTLLRDHGKKVQKYLWKSKKLEVTKKSLKTQVNIVLVDARDLPDEISSNTNGLYCKFRLGNESHKSKQVTKSKPEWRERFNIYMYEDSNLEVKVWHKGKQKTFVGRCVIDLSQLERERTHELWQELEYGYGSIHMLVTLGGSERCVSTDNLTLANGVTHQPTITEEKYTWYRLENNWNEVGQLSVTVHGARGLSSLGLNGNIDAYCVLEVDNARVQTHAVRNSSDPTWNKNFIFNINDVTSTLDITIYDESIIQSMKGETLGKISIPLLRINNNEKKWYALKDRSKKHSAKGNCPRILLEMSLEWNPIKASLRVLSPKPTKYVEKPPKFSIPLIYNNLKFIKVVFDYIYLGNVYFKNTFEWENREKSALALGAWLLFWYFFRMWMMPLLLIVPFLPYWAMYRGNNCSQLLPILTDEDTSEEDSEIQKDDKTISTRLYELQDLTFTIKNGIDYIVSIIERLKNLINFSVPYLSYLAIIGLIVASIAFYLIPVNYLFMALGIYKFTRKAMNPNRVPNNDILDFISRVPDNEILKQWRELKVTESSISRSDSMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8D7</accession>
    <name>A0A194R8D7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein trachealess</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A194R8D7">
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    <dbReference type="InParanoid" id="A0A194R8D7"/>
    <dbReference type="Proteomes" id="UP000053240">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Neuronal PAS domain protein 3 isoform 1"/>
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    </dbReference>
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        <property type="entry name" value="Trachealess, isoform D"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF26">
        <property type="entry name" value="PROTEIN TRACHEALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="704" mass="77045" checksum="AD2644B0C0C8487B" modified="2016-10-05" version="1">MRSESTNPKEIKNKLYTSNDRRAKKSLDGFALSVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYVHQNDHAEIAEQLGLSLAGRGGGAGLNSPASGSEEGSQHGTNNPDVSSQMSLAASGVLFRGMDRAFCVRMKSTLTKRGCHFKSSGYRVVLMLCRLRPQYTFSHSRKSPPALLGMVALAIALPPPSVHEIRLESDMFVTRINFDFRIAHCEPSRVSELLGYTAEELTGKNLYALCHGEDANKLRKCHVDLMNKGQVLTHYYRIMNKLGGYTWMQTCATVVCSSKNAEEQNIICVNYVISGREYPNTVMDCCQLEESVQGVKREETTGDPENGPPDADTPGAPPPPTRHTTERNEAPTNSESASTVPPTSDVTHLTRLSDTQPLPLHTNTERTSPMPARRMKKRKHTTDCEEETERDEERRKSNSNPGTAISPADMSKTNLAIPEGGSDATSVRDLENAMSKHLPSVALDGKEISHRPTDFSTDALLKQQQQKSTIQWIGTQNHHLNHLNRQIPGNHTPNPASALLRQLYANRESVIRSNFLGDGRGGGYYSSDGQSGPLPTPPGSEGSGYGEQIGHKSTEIGSLAYTSYGDYHSAMTPPGSVSPRDKQQYAISYDNSAYSDALRHSYLGEAPLPLKPQAYSAVPGALDYASPLDQSQFFHPPSSFHLYHPQAHSAHPSHPHQSADKTAPPNTNWYSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9C8</accession>
    <name>A0A194R9C8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide FF receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_06987</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9C8"/>
    <dbReference type="STRING" id="76193.A0A194R9C8"/>
    <dbReference type="InParanoid" id="A0A194R9C8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF41">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="22274" checksum="7CC3DC9665C1A597" modified="2016-10-05" version="1">MAPLRVPTDFFTDDVTDFLNYSTQHPGIESPRHHLRHRNHSRDHSRNHNVVDMLSNSIMEVINTKFIPDNSVLPDMEPLSTHMDGQERHPLKMNITMNRSDFGVISEELLYRHSGAMTAVYCVAYLLVFVVGLVGNCFVIAVVYRSPRMRTVTNFFIVNLAVADILVIVFCLPATLMSNIFVREYSSCLKIDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB70</accession>
    <name>A0A194RB70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB70"/>
    <dbReference type="InParanoid" id="A0A194RB70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8472" checksum="D3CCCFA26EBE6CF9" modified="2016-10-05" version="1">MSLHTIWILRPFTERHFVHEQSQKRQDTTVAHDERHATALHFSSLRPLPLPAVSIAPEISWQPLLPLLSYAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBD2</accession>
    <name>A0A194RBD2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein CG6153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBD2"/>
    <dbReference type="FunCoup" id="A0A194RBD2">
        <property type="interactions" value="1937"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBD2"/>
    <dbReference type="InParanoid" id="A0A194RBD2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="28335" checksum="B54E4A52D408B8B6" modified="2016-10-05" version="1">MPHSHCNHGSHDHDHGNPEEIGLQYNLYQKIDKENVQCLNESVDGSGKTVFKPWERRLDTSELSVLNPTVQREFLKMFFAIGPLTNMPIEIINQQLKCWFQYVESDADEELLFNIPFTGNVKLKGIIIRSEDSDLHPSKLRLFKNKPNMTFDEASMEPDQVFELQKDSQGILEYTPKIVTFSSMSHLTMHFPTNFGAETTKIYYIGLKGEWTPGHKHGVTICTYESRPMLDDHKLKHLDSVGRPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC90</accession>
    <name>A0A194RC90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC90"/>
    <dbReference type="FunCoup" id="A0A194RC90">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC90"/>
    <dbReference type="InParanoid" id="A0A194RC90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF39">
        <property type="entry name" value="GH10366P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="694" mass="74293" checksum="37EEBD5B3D55CCF3" modified="2016-10-05" version="1">MDIGNYYSSPVQKMHGKFKVLLIIIVIFCGISIETAQASPNLTKYNTSRSNEYVMQRNETPTSELFHWEDYSVLATMLLVSCGIGVFYGFCGEKQTSGDDFLLGGSAMGTFPMALSLAASFITAIELLGNPAEMYMAGAQFWMICVSFVLVVPIASQLYLPVFMRLRLTSCYEYLEIRFCKSMRVYASSLYMLQMVLYTAVAVYAPALALSDVTGLNTYLAVSLVYVVCIFYASQGGMKAVIMTDSFQSAVLLGSLATVLIMGAGKVGGLDAVWDYARATDRLHFFDMNPDPTVRHSFWSVVVGGTMYWLSMFCANQASVQKYLSVERIAQARVALWVSACGLVAVYSVNFVTGAVLAAHYADCDPIKAGVINASDRLLPLYVVRELGTSRGVPGFFVAGIFAASLGTVASALNSLAAIACQDLFSGLLGITLPENKGATIAKWVCLACGALSFGLVFVVERLGPVLQLAVSFNGMAGGVSLGLFSLGMLFPWTNAKGAVAGGVFGLVVVVAAGGGAQLAQLPAPRLPASTAACPAAENHGESVFWLFRVSYLWYSGLGCAATLLAGLVTSVLTGVTDLAHVPIDLISPPVISFLNSLPTKLKKALRVPTRFGSERRRSSSVRPPSVADDKDTRRRRRLSELAGGVFYSDTPLTRGLDNPALGLDPEKPPPDDCVHHTFTLDPTASHCPQTSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD96</accession>
    <name>A0A194RD96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
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            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="220"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="310"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="414"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="513" mass="56554" checksum="BA907415597F596C" modified="2016-10-05" version="1">MPLPIEEDPIINADIRDDVTSSNRNLVEVDREETTGWIKSRTVLGIMGFLGFANVYAMRVNLSVAIVAMVNSTTVQNNSTLDVCLAPTPSNTTIPPKPGEFNWDAGQQSIILGSFFYGYVLTQIPGGRIAEIFGGKLVYGIGVLLTAIFTILSPIAAKVDFKFFIVVRVLEGLGEGVTYPAMHAMLARWIPPLERSKFAAYVYAGSNIGTVISLPISGWLCTLDYAGGWPLCFYLFGGLGVLWFIAWMFLIYDTPQNHPRICPKEVEYITNSIGVQEDKPSMSIPWCKFLTCLPLWAILIAQCGQSWLFYTQLTELPTYMNNILHFDIVSNARLSALPYLTSWIAGIIISIFADWLLAKGWISRQTSMKLWNTVAAFVPAFGLLGIAWAGCDRTAVMLLLSITSAFGGAVYAGNQMNHIDLSPQFAGTMYGITNAASNICGFMAPYVIGQIISSDQQTLGQWREVFYLAAAIDLAANLFYLFFASTEEQDWSRPDNDDMTASAPVESIMYPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDA9</accession>
    <name>A0A194RDA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cubilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDA9"/>
    <dbReference type="STRING" id="76193.A0A194RDA9"/>
    <dbReference type="InParanoid" id="A0A194RDA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="47"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="184"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="299"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="45061" checksum="BB1EB3B02F1C25BF" modified="2016-10-05" version="1">MCGYVNSSTTINSSGNEVLLQLVTDISAAYTGFQVEIIFSYSESAGCGGQIDLNPTSSHTLKSPLIGNSFVYENYLDCTWNIKAPHDYVVNVEFISFHVSSCYNVNQTALGISTCNCDFVEFRDGINPNSIIIGTYCGHTLPPQIHSTYEYMSVRLATDGELASSESSRSYRGFEIEFITSGFCGRNYTDSQGRIKSRYPTPEDSTDCYTLITAPEHHTVALYFLFITPEYDNENVYLDIFDGNSTTSPLLVRFAKEAVRYSAVFSTGKSLLLHNHGGDNKRMLTFDSNYVATDKGRGCGGKLNNVVGRVMSPLYPEVYRQKSTCEWELETPHGTRVMVHFEVFDLGVVCDQNYLQLVNRDGNTISTFCSETPADYTSVDNYVKIIFTTTLNNGGTGWVADFVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDM1</accession>
    <name>A0A194RDM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDM1"/>
    <dbReference type="FunCoup" id="A0A194RDM1">
        <property type="interactions" value="1687"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDM1"/>
    <dbReference type="KEGG" id="pmac:106709881"/>
    <dbReference type="InParanoid" id="A0A194RDM1"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="371" mass="41404" checksum="3D5FF8FF491645A6" modified="2016-10-05" version="1">MAALRVFSRNIPYLRQQFSALLGNTSPSVKFICVVVIIGYVLSYSESVVNVLSVTPGFLLPPSFQLWSTFTFWFLEIHLWEVIIDIVTVGLCGKLIEPLWGQMEMMKFFFLTNIGVAFLTTFYYLVIYAWTQDTSLLFDIHVHGLAGYLAAVSVAVKQIMPDHLLIKTPLGKLTNRSLPLLILIAAIILWAVGALEGTYPCMWGSGTILSWVYLRFWQRHSSGTRGDMADNFSFDNFFPTVVQPVVRAVLGPPARCLARLGLCPSPPRRVTLALSPRGVTISMPGVEPHDMERRRQIALKALSERLSKTSEQTRQKNLSTKVNMDAVRKMQASHVIPQFPAETTEQKPPSVPETTLVDISAEPSTPTTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE07</accession>
    <name>A0A194RE07_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proclotting enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE07"/>
    <dbReference type="InParanoid" id="A0A194RE07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Clip" evidence="5">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="396" mass="43949" checksum="6EEC864D6C2BF72E" modified="2016-10-05" version="1">MAESPTMQVLPRNPYWYQNSMPRKRSPDSMQRQYYGPSQYNQQLTYYNNNQQYNQNPNQIQQTYPHYDSRSSVDLIHSETRDGIPNDGRLLSDSAFSRISETLGAINTVGHYLVDIVNENERNESNPNLQQLPQALYTLSKNVLGRNVTDKIAPIVKKALPKVLPDAPITKIATGDVSQENDAKYCTTPEGEAGVCEDLSNCPQLLLNLINLRESLCFKDLFVPGVCCPRDAVIPSITSAEKPVVATTSKPTYLLPVSSQKPVTKPTTTKRPSAVLVLTTKKPKPPTTTRPSTTTVAPVTTPRPVSTTSFYTELPPSIANYSNIVDASECGQREDEGGRIVGGTEAKSGAWPWMAAIYLHGNKRREFWCGGTLVDRRHVLTAAHCTRDSKQRPCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE38</accession>
    <name>A0A194RE38_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE38"/>
    <dbReference type="KEGG" id="pmac:106709740"/>
    <dbReference type="InParanoid" id="A0A194RE38"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="3"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="539" mass="61433" checksum="9B293F7ADE80FE94" modified="2016-10-05" version="1">MVQVKVREGILEGEVVENELGGHFYSFKGIPYAEPPLGELRFKPPQPKKSWDGVREAKKFGSICYQVNILAMKSTPTGSEDCLYLNVYSSDINPSKPLPVMFYIHGGGFLSGSGNDDMCGPEFLVRHEVVFVTFNYRLEVLGFLCLDTEDIPGNAGMKDQVAALRWVNENIANFGGDPNNITIFGHSAGACGVSYHLISPMTKGLFQKAIIMSGSLNSSWGQIFEPRERGLALARRLGCNSKNDKELYEFFKKQPVESLVNIQIPISFNEKGKELFEFNLGIVSEKYCGENERFIYGDVIAKLRNGIHEGIDLVMGYTKDEGLINLRTDLQKILAYANEYTESFVPTPIANNCTMKEQFEVGRKIKYFYFNDDTITMKNLNELIKFISLSTFTYPMFQLARSCSRTNRVYFYKFTGKSERNLMAQVCNVKKILGDEIPVCHGDELYYIFPMKRTKLKICNKSKSFKIIDNVTKLWTNFAKFGNPTVHDSFDFEWSPYNSVEQAYLEINENLTMGTEPDKAEVDFWENIYRKYLPSSIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REU3</accession>
    <name>A0A194REU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REU3"/>
    <dbReference type="STRING" id="76193.A0A194REU3"/>
    <dbReference type="InParanoid" id="A0A194REU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="13675" checksum="61B3DDB98B4A49C7" modified="2016-10-05" version="1">MRPGPAPAPRLASSAFDVTPKFIGGQLITSFLAIEGDGVGSNTGSPKYAQIPQMNEAISAPPQQVPLMYCGMVSPQPSFCNVSDMSASASGDDYEYTGGSGDGYQRSAKRSYHGSSSGGTASTPSYHPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFX9</accession>
    <name>A0A194RFX9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor RBM22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RNA-binding motif protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_08098</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFX9"/>
    <dbReference type="FunCoup" id="A0A194RFX9">
        <property type="interactions" value="2005"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFX9"/>
    <dbReference type="KEGG" id="pmac:106709191"/>
    <dbReference type="InParanoid" id="A0A194RFX9"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12224">
        <property type="entry name" value="RRM_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000476">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057674">
        <property type="entry name" value="Znf-CCCH_RBM22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25584">
        <property type="entry name" value="zf-CCCH_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="44791" checksum="55F8B1C872542399" modified="2016-10-05" version="1">MAMSKSTNTYNRQNWEDSDFPILCQTCLGDNPYIRMTKEKYGKECKICCRPFTVFRWCPGSRMRFKKTEICQTCSKLKNVCQTCLLDLEYGLPIQVRDAALKIQDDLPRNEVNKEYYIQNLDSQMSKFDPTQPSNSALKSKGASDLLLRLARTAPYYKRNRPHVCSFWVKGECRRGEECPYRHEKPTDPDDPLADQNIKDRYYGVNDPVAEKLMRRAAAMPALPPPEDRTVTTLYIGNLPDNVTEDELRGHFYQYGEIRCLTLVPRAQCAFVQYTTRSAAEHAAEKTFNRLVIGGKRLTIKWGKSQGRQGVNEKSDMPALEPVPGLPGALPPPPPAFLHPFPPQMPPPPNRPNDFFNLQHYAGPGWGWAPPPGLHYPSQDPARLGAHAHANAPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ03</accession>
    <name>A0A194RJ03_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone H2A type 1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_09967</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ03"/>
    <dbReference type="FunCoup" id="A0A194RJ03">
        <property type="interactions" value="1606"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJ03"/>
    <dbReference type="InParanoid" id="A0A194RJ03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="14">
        <location>
            <begin position="383"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="738"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="815" mass="93141" checksum="81F48F550BBC3DEF" modified="2016-10-05" version="1">MSGRSAERIKKRAKSKSRSARAGVNFPVGRIHRILRKGNYAKRIGCGSAVYLSAALEYLAAEILELAGKAASDNGKSRILPRHILLAVKNDDELNKMLEGVTISQGGVIPRIHQQGWRGHRGRGRGRGGRGSWPRNEKFHDQQTPYGNQNRGFRGGRGNFGKNKMPSRETPGKRLSEEEIGVTEYMSDHKGFNGIIKCRYSDFQVSEINESGEIAKLTDMSPPVPPMEETIEEDEDLLLSKYNLEILPMETWDRINTLIVNPPTDKNVEVDVTGMSKEERTKIHDSVKKAFGPSLVSSTVTIGDKKIVRFEKFKKGVRRDNRVKWVWPGEYVHFVLHKENCDTMEAAMRLAERLQLKFRIALRNVTASDEVIDEACERLRKRGFINYYGLQRFGTRVDMPTYEIGRKLLQSNFREAVNSILQDRESSRSMGRATAGEARLQRALNNNPRDLVGALDQGRIQEVTDNNYVQEATEHKEENKQKNKEQEKNVPKPNIPVKVLTEEDIASGRYSIFDIVMPIPGHNVEYPPNMKEYYKELVEKDNLKLDMIHKNKAYSLSGAYRHIAVRPEELEWLTVRYHEPFCDLQLSDLQELNGHTDTGIVEDGKGAPIQQCTQTVLGITSTFRLSSVWLWYFTERVQFLQLMLLLASTVLAYSLSGAYRHIAVRPEKLEWFTVRYHEPFCDLQLSDLQELNGHTDTGIVEDGKFKACLLTITLPASSYATMALRELLKVDTSNDNQAQQNNYFKSKTEDKHETEENKEEGERESDSKQDKKDDDSSQHNENDENNDNKGEKRKIEDETEVDVKKKKEDNVDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL62</accession>
    <name>A0A194RL62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FUN14 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL62"/>
    <dbReference type="FunCoup" id="A0A194RL62">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL62"/>
    <dbReference type="KEGG" id="pmac:106709013"/>
    <dbReference type="InParanoid" id="A0A194RL62"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="19166" checksum="47E1F65D89EA79F9" modified="2016-10-05" version="1">MAKPKTEDASEEAKKIVDDAKNFIEKAIGDIGKTSATKQLILGTASGWITGFITMKIGKFAAVGIGGGVILLHIASQKGYIDINWDKINKKVDKISDKIEKEATGKSPDWFEKVERFVDRKIDKAEDLLKKKEKKAKKWFNNFTGDDHYKATETHIFLTSFVAGMAIGLLCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMI2</accession>
    <name>A0A194RMI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protease serine 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMI2"/>
    <dbReference type="FunCoup" id="A0A194RMI2">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMI2"/>
    <dbReference type="InParanoid" id="A0A194RMI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="279" mass="30655" checksum="6D9CAFFDD225E4EC" modified="2016-10-05" version="1">MLKRSQSVADIECGVQSARRGRIVGGTESLPGEIPWAASVWRQGTHQCGATVINDRWLLTAGHCICSVFDEFYKSKQLTVVVGYTDISYNDVNQPLSRIIPHPEYRCNRKSNDVALLKTVRQMIWNSDLRPACLPQASSSDFSGTPAVVAGWGFTNEDRGIGSRPNVLQKTDVFVVTNDECNNWYESQGSKIKIISTQMCAGHEQGGRDSCWADSGGPLIVRGNKGHSMVVGVVSTGSGCARAKMPGIYTRVSRYTDWIVENVNNDNARSVFSLFSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMU7</accession>
    <name>A0A194RMU7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin conjugation factor E4 B</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase E4 B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin fusion degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_10599</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RMU7">
        <property type="interactions" value="2499"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMU7"/>
    <dbReference type="InParanoid" id="A0A194RMU7"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000060">
        <property type="entry name" value="ubiquitin conjugation factor E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1231"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="855"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="855"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1304" mass="147451" checksum="2C1347D54943F585" modified="2016-10-05" version="1">MSELSQEEIRRRRLARLGALGATPSSPAPGSPPATPGASLTNTDTVNVQQPSSRLSPSPRGSTESNTSSDSATINRENNFADGVSNSEVPDQNKIPSDSLIVTEKTENNLLDEMPDTKMTDLSQTRQYNSFDSMGDDTLLSCGSVRVGSLPQSTVSGSEGASTREDSTSRSISPPQFVEPPPVRPRTCVASPSCSRRSLSMEVDDVSERNSQSEQSQQEPMDIEEDPSQSPARKIHRTRTVSCTELSEEQLRVIVSKILQISWSEEIVGGMFVPIVAAMLLDNPKLSLEELASEALIDIITQLEDGADPLNQKLIAIAETTKRLMEDCGDDTLTSGPLGSESDNQKGGSTVNLVLPKTIPTQGLAVSYLLRFYNNINLYEREHPKKSSEPPLSDLLQTLRTLIVNHLVLVLRGKFNLEKCRKSPLLPYILIGSTPIGLIPEILLATYLEESFEEVFVPLLLGIREEMRRSVSPLNGRGHGQALRALRSLCELRAGPRHALRPICALIVRLPSLCPPSVTTAPGREIARASFLGPFFAVSLFAEENPRLAERLFATGSSDRSLAFALQRELEASRNTLHTICHNILLCPEAREPFLNYFAELLQRNEHRIRYRNDDRSLAASRNTLHTICHNILLCPEAREPFLNYFAELLQRNEHRIRYRNDDRSLAGDGFMLNVCSVLQLLSIRIKLERVNPFYTFQPNTWIDIHDDTRLYYTSQEAQDWLDALNKDPNHKWPEAKFQTVCWFLTLHMHHVALIPALHTHQRRIRAFRDLQKVIEELMAAEPQWRNTYAALRNRELLRRWRRQIKRLQRSKQCAETALLDSDLMRRSLQFYSSVCVLLTQQLEAARTADRAAANLESPDAGSGSESAAPSAEGGAPRAPHGPSAGSLADAFRATPEWYVEDIADFMLFAVQYVPQIVADYIEEPVVTWLLTAVCNSRLLKNPYLVAKIVEVLFVINLSIPLKLKNVYERFMDHPMSQTSLPSALMRFYTDIETTGQSTEFYDKFTIRFHISIILKGMWDRPIHKQAIVKESRSGRQFVKFINMLMNDTTFLLDECLTYLKRIHEAQEGGPSTEVRARALAQDERQCRSYLTLARETVDMLEYLTVDIKEPFLRPELVDRLASMLNFNLQQLCGPKCKNLKVRRPEKYGWEPRRLLSQLVDIYLHLDSPHFHAALAADERSFRKELFEEAAVRLAKSCIKTPNEIERFKALADNAYQIAVSNQQKSDEYADAPEEYRDPLMDTLMTDPVVLPSGKVMDRSVILRHLLNSATDPFNRQPLTEDQLRPASELKEKIIQWQREKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMV6</accession>
    <name>A0A194RMV6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_08517</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the hemolin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMV6"/>
    <dbReference type="InParanoid" id="A0A194RMV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF56">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="194"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="285"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="441"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="541"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="660"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="754"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="851"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1101"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1199"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1298"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1395"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1503"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1009"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1719" mass="185465" checksum="BBD0B11349C7F1AE" modified="2016-10-05" version="1">MQIGIFMCKERPEGLMPQRGSSPRCQYPFVTPVANGIMMDVAWEVRVHATAGVAGGAALLTCVPTPAVRAHVLHTAWYKDGLALAPMASDTGQSNVLNVPNMFWSGARVQICRRPPDEKRIGLIIAAICQLYHWLPAGRYVVGGSRGDVLVVRDARPDDTSAYTCEAQHALTGEKRRSPPAMLVVSHSTGSMAPRMLTISEDETVTQGGDIRLVCCAIGSPPPTYSWFRHLNGRLSPVSASVRVSVAQQVLVIRRAQPADAGVWTCRAHNQFGEQRRDATLRVRSRLVVTVHPQLQVANSGSSVVFNCTVEGGGGEARVRWLHDGVPVGGAERTLRVHGVARAHRGMYQCFAERDLDSAQAAAELRLGGRIDNKSIAKSSWKASATIGSYKSVMEKPKQNPINVRKCRHRHINKATGAVWEADTARRRAMYGSPFVTDTAPELHYTFIEQALHPGPALALHCAASGAPPPRFTWLLDGQPIEELNTPQRSISQFMRPNGDVVSYLNITSVRAADGGRYTCRAHNSRGAAEHSTRLNVYGPPSIRSIGPLPVVAGVNATVYCPGFPIRLMEVHHASLRLFSALMSRSTPQAFCVAISEIRWQRGGDGAGGELGGGRATGAGGALRLWPAEPADAGLYSCRVTAPSGHYAQKDVQIFVRNPPKIAGFSFPADLVEGSSVQVLCGITSGDKPVYFSWLKDGQHIPSNLQVQEKSLDEFSFLIFSHVTSQHSGEYTCVASNTAAEVNHTARLAVKVAPSWVFEPQDASVLLGTQIIVHCSTKGYPEPQIAWLKAQGGGEFRPLSQLEPAPLLVLRNGSLSAAEAARAHEGRYMCRADNGVGRGLSKVITVSVNEPAHFEFSSRNMSVRRTAGAALVCAARGDPPIQLHWTHNTQRLDLSTYRVSVSEKRSESGASSTLSIAHAERRDSGVYRCRAENAYGRDELLIYLAVQEFPEAPRSLRVVWRAARAARLAWRRGYDGNARLRAHRLQYRVVGATQHGTLLGTQLGTQLGTQLGSQLAGPRPQQADWTDAPTREIPPDLVQQRQESTEGEREAEGDAVLEFSVEGLRPATAYALRIAAVNDIGDSDYSDPVIVHTLEEEPSEPPHNIEIQADAPGELLVKWQAPPQESWNGELLGYAVWWRGDNASHALTVPGWRSARARLGALRPHARYELRVQAYNAVGAGPLSAPLGAATLEDVPESGPQGLRCEALSAQSLRLWWEPPPPPERGGLLLGYEITYQAVNLEGELQGMPETRRAGSAEAVVSAARAGNYSLQVRARTAAGAGPPAHTYCATLDDVPGPPADIKAVANSESSVIVSWLAPAQSNGRIHHYTVYNRPQRTGQQAQTAVLPAAGAREHQAEVRGLQEHQLYEFWVTAATAAGEGEMSAIVVRKPTSRPPVKLWSFPRRITAAEGSRVVVTCGAVGGTAQRVWARRRSPPPATDPRLIIDSYRLIIPRFGCAPWIRTVLSIYIFPELDVSLSDNYTCIVRGGGGEERGTWEVSARSPPPRPRLRLAGAAPHSLLLAWDPPPALEHVHSYTLEHTRVGGVGTVESAGEGEGAWRSVWVAGSARAHALRRLTCGARYRVRLSALGPGGSSPPSAELIASTSGGPSKAALEKHLFTSNSSCVRLNLLTWDSNGCPITHFVISIKGFEESRWRTESVSLEGCARGVHAVCALAPGAWHVLRVAAAGAAGSTTATYYFATLTLAGGQLTSPPISLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNG0</accession>
    <name>A0A194RNG0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lachesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNG0"/>
    <dbReference type="STRING" id="76193.A0A194RNG0"/>
    <dbReference type="KEGG" id="pmac:106720610"/>
    <dbReference type="InParanoid" id="A0A194RNG0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF3">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265323" evidence="1">
        <location>
            <begin position="25"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="195"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="303"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="446" mass="49282" checksum="5A4A687BCBFA4715" modified="2016-10-05" version="1">MCASATAALLLGILAFLPSRGTEADTTLTILKETREAGSHPTINQLYQMLYRGPDSHNQTKLLANSNFSNLDIIPTLKPHNQLEYSSPSDKQVKCCYNASFPSQFTANKHTEGVHEVNITKNHKKFRKRRVLNVTRTEEFIGYGYYAEATAVPMINTPPVMERRRKIGEVGSNAPLLNYIFDTYSNTHQHRNEKPGNGNSIYAAAAPEMEALVGSTAHLDCKVDALHDKLVSWVRRKNDEEPMELLTTGTQLYTADKRYSARFIPPDIWRLEVREVRPTDAAHYDCQLSAHPPRTARVTLLVPEVSVRIVDGAGASVTEQVCELGSTVALRCEVRGLRMEGGPSLLWYRREYLLNDDTTRGGISVRTEFGANGANSVLRVARVRADDAGRYSCSVARAPPPAPPPATVMLHVIKGESLAELHQGKGTSLIPGIVIFTLALCAILYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNM1</accession>
    <name>A0A194RNM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNM1"/>
    <dbReference type="STRING" id="76193.A0A194RNM1"/>
    <dbReference type="InParanoid" id="A0A194RNM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="977" mass="106640" checksum="498143DA8C62EBAC" modified="2016-10-05" version="1">MLRSETCEEFNSFNASCSTNIDNCDYKNCDNNQSRSTVSENLECDSLDNSFNSDNSIKVKVTVKLQDEVCDNKTCEIQSEPPVVLPSPEPKSDKSKSAGEEKIDLFKGIERTLSELLKKELLEEQGEEKTHGARPARDVTEGSAGAPVLAPVCRSRSPGADGSARFTSRVMITHDRVSVVTSDTTRLMRDITVHHTNSQNVLEHDASATTSQNDTNERVSDDESAQPSGGVTVVSNADTLSAVVCLEEGLADDDSWVEDVSHDEDATTTSDSDSGDEASLPTRGEDFAYCRRSLDFTLHTIVEESCEESEAENNTKKSRPISATELEKYFFFGLGDGRNVREDDDQVSETSSVCSEGGESIVDSEQPKRSNDNDELVSSRLEKYFLSGFMGFNQERRDSDGSGSVGSDSEGKQSPEQRRKRLVRARGTPRSHSSSLDNLLTGDEPSQDAQEVSDGSSTETEDRHESLERLDMPGEAKRKKQSKKTRGSPADERRQSMEFSEEARDDTRSVSEGEDGRSTPRPEFPPLGSELSESKKQTSRDSGFVGSCDDLLRNGDSSAEFTRSHEPKTELEEIVEEMRPDLDERVERPPSSRPPPSPLTRKDSFNNWSSDEETNLMMTKMRQFFKQMINSGNVRTSTPASTNSESSRPPKPPQLLYFETELTRLMKTVPGIRDEEVREIVEYLSSEDTWSDSYDSSDYAGSDLEGTSANRSALRKQISDSCREIIDEFDRGNDAGSLERDAVGAYQKLAATLGRAGEGSPPLFGKVMRHIGGRLVALMHEVSGGASPSTDDDSASEPGALARSRSHDILEATASRGSVASDCERFSWRGSFESALLAADSRGTLGGPSCESRRSPAGADLAAQKSHSRSCGAIAGSEDRLWRGRRRASAPDAESEEEERAGSLPRLPSITGTNTVPAGPVKSARYRAPGFRSATRAASAPGLHLPRRRRPAPTPHQPTPAAPASAPSLQGKSLTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNR9</accession>
    <name>A0A194RNR9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNR9"/>
    <dbReference type="STRING" id="76193.A0A194RNR9"/>
    <dbReference type="InParanoid" id="A0A194RNR9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="525" mass="58796" checksum="FEB1736A49CDDEED" modified="2016-10-05" version="1">MADSLISEEIWQSVRELVGRLRVRQQFRGLGGELMRQACCRCIARLSQAAAPCHHHPDIIDEWLDLIEECLGHEVQVIREKAIQALPVVFEQYLSHDSSRQKRAELMQKYCHQLASTSANGLLLRMGYSRAIGALPKFVLSEHLPLVIRSLIECTRVTEATQKWAESRRDAVIGLTEVCHTQGIVDGVEKYVEEIIDALLACLSEYTIDMRGDIGAWVREASMTGLLSLCRACAVEAPQLNSARAVCAAVRGAAQQAVEKIDRTRAHAGRIFTAFIYNDPIISNIPHHEALKRIFPYDEVELRGGGEEAESGEHAVVSENSNVVLWLFPGHTMPRFVQLLQYPEYRYSVLKGLVVSAGELTESLVKHTTQSLYSYLHTLHDDLPTLRSVCDTIVQVFADNLHVKRITGPMFNFLDRLLSSGAISPILDDPESTFAADVLKYLQLELRGGKNIYKLLDSINVLCQLIQVGGTVCSKALGQLVIYLCYADRYVRRCAAARLYEALTLYGDTCTAPQHNLDQVQYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPD0</accession>
    <name>A0A194RPD0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPD0"/>
    <dbReference type="STRING" id="76193.A0A194RPD0"/>
    <dbReference type="KEGG" id="pmac:106718151"/>
    <dbReference type="InParanoid" id="A0A194RPD0"/>
    <dbReference type="OMA" id="HAINLLM"/>
    <dbReference type="OrthoDB" id="10016665at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14326">
        <property type="entry name" value="UBA_UBL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047878">
        <property type="entry name" value="UBL7_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF25">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="381" mass="41039" checksum="886DE31A7D8079D5" modified="2016-10-05" version="1">MEPSENQSYVFLGVKVKPGPIERYKLDNFTLENKVINLKAEAEKRVREPSSSLEAIHHGKILRDDATLQDCGIKYGEMVHVVKKKIPVKSPPAPTFSDAELQQLNTSLRTLGCTPNAPGWTRAMQLLNDEATLAEVVDQLPSLNEDCVALSILHEVELLAALGANVETMRRGADAHPDLPAALRHLTRLVRSRNTASNENVPTSGFAYSLEALSEDEDVEEEETEEGSGERNTITREQLTAALQAATEAAFSTNTSNARESRENLIRILDAAADSRGTARSASTTEASTPSGSGAPPIITTEMFNEAMTEAMSRAGEQSTAAPETSFATSSQNQGNYATQISHMHEMGLMDDALNIRALVICSGDVNAAINLVFSGAIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPN1</accession>
    <name>A0A194RPN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 25 member 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPN1"/>
    <dbReference type="InParanoid" id="A0A194RPN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YEATS_AF-9_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <end position="355"/>
        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="1026"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ19364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1100" mass="125496" checksum="6CD75EBC352BD0B2" modified="2016-10-05" version="1">MAGFGDYTGYNRPFGFDPNRESNDLYDTRYQQIYGYHTPMTEEFQGPPLVMDDIPEEENNTFVTTAISVASLVTENLLSHPFIVLRRQCQVNRGLKSYHIVPYTLLPVVVKLHRRQELTTLWKGIGSTCIVKGLNLAVEDLISKGTNWPNGKKTDSEEVVIFLKTPIIISSLYVPAEGLGAYPNLGGVLGHSQPRWPSAGWLTSHISLNFFSDMCSLLLRKITIKALRFQQRHRHELSDSYNSNFPKNTQNPLIEDINLKANIFSFITMEIIFYPIETIIHRLHIQGTRTIIDNLDTGTSVTPILTGYEGFMDCYNTTISKEGVSGLYKGFGALVLQLAAHLAIIKLTTIVVTEVCKMSTIKVCFEIGHTASLKSKKSPEGFTHDWEVFVRGTEGADISHFVEKVVFHLHETFPKPRRVVKEPPFSISESGYAGFIFPIEIYLKNKDEPKKITFSYDFTLQRTGSLKDRFIFQNPNDDFKKKLLKGGGIVTTNNAFYTNPDQENRSRDSFTEEKQQLVSKPKLSSENVKKHKSKEYKEEIPHKTSSFETLFGAPIQKPPKVSPDPKKVEKNAIAIKSQKKEKDRSSSDKKSKHEHKEPKSEKVKMKDEKDKIKAEKLKNHKDAERNKDKPSKRPNERPPSPDLVKKRCVSPVRRPQSPSQRSNSASSIKEEYKSKHLSENFESKKPKNEVESRPVEVKVEKEGKEKKKKEKKSHDRDKERKEKKEHKKESHKVKDSPKESPKELLKVKEVIKEKEQTRDTSHSREKPQKPEKIINKFSIERLRKTPPPEAEEHVENRKSKEKGDSERKHKHKKKDKKRDESKEKHKESSKEKKSKHEKVVKEPPTEKPEIIERRETPNLKERSIPEPASPISIDTASQCSSKSGLVKASHISTEDVNSSHSDSEVSLIADDDDDKVKIENPSPVVKHDPSPEPEPEPEPEAEPELEPVVEPPPVQQKEKSKKHKDRSKREEKRRKRKAAEEEEIESRKMAKTNELGVSNNDTEHGESSGSVSAETKVQDNGVSSSLGEDAEPGDLSPDYMVQLRGLQQRIMMIKNNEDLERVVNLIAETGRYEVTTQTFDFDLCMLDRSTVQQLIQLVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR74</accession>
    <name>A0A194RR74_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN2/TERF1-interacting telomerase inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RR74"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="584" mass="68416" checksum="9A157DB925BD764B" modified="2016-10-05" version="1">MSMLAGPRRKQKVINLRAKNNEWSNDTNKFGQRMLEKMGWTSGKGLGANENGIVEHVVARYKNDEKGLGFEDKNDQWTKHEDDFNSLLANLSNATDDGPKLHSGVSLEDKSKKSKTRIHYHKFTRGKDLAQYSEKDLANIFGKKSFKQEDVTESPLEEKTITTEQVFTEKGSMEDYFKNKMAVIKSKNKTSHIKQVQPELDWEDEPRCGFQGFLGTADQKDIVENNNLLENNLDDRREFTNHLVNDEKVENFEDHPKIKKKKKKKRKDIEEVIEFCDMTEDEPPIEKLKKKQKVYAKNSGQESDDETRKGCKKQKQDKNEMEELDDKLEAVIPKKINLASEEYVFIKNHVRELKNPQNKSEIQDENKDEVTEQKVLKIKKRKRKRSSSESSERISKCCEINKDDLEELRTLYNKCKKVITNIENKYGHLLNLFSEPQTTSSYLENIEDKEECTCEQNKKIIFDDEGKEILKDVEFDRHICVKNHERNHRNILPDVHVEYEHETSQKDAIELPDDLNELENILKNPATENKLRRRVIYKIRSLRFDYIREIRFNRQMLVEKLKSNPDELLTFTGSNLSSLSGYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRL5</accession>
    <name>A0A194RRL5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRL5"/>
    <dbReference type="FunCoup" id="A0A194RRL5">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRL5"/>
    <dbReference type="InParanoid" id="A0A194RRL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11238">
        <property type="entry name" value="Sema_2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000369">
        <property type="entry name" value="semaphorin-2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF90">
        <property type="entry name" value="SEMAPHORIN 2B, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="26"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="715" mass="81437" checksum="6FDFF4A4925DE0C4" modified="2016-10-05" version="1">MYLTSRFQNACKIFVKISSTKISTYFLTLPIQKLTLRYKNGGFNFLSFVTDHVREFTCGPLYYRTFFMDSKRDALYVGAMDRLFRLNMNNISSSHCDRDSINLEPSNVAQCVSKGKSEHFDCRNHVRVIQPMGDGSRLYVCGTNAHSPKDWVLYSNLTHLPRHEYVPGIGMGIAKCPYDPADNSTALWVERGNPGSLPALYSGTNAEFTKADTVIFRTDLHNLTTGRREFSYKRTLKYDSKWLDKPNFVGSFDVGEYVLFFFRETAVEYINCGKAVYSRVARVCKRDTGGKNILNQNWATYLKARLNCSIPGEFPFYFNEIQSIYKVPGDDSRFYGVFTTASTGLMGSAICTFTIGDIQKAFEGKFKEQATSSSAWLPVISSRVPEPRPGTCVNDTSSLPDTVLNFIRSHPLMDSAVSHENEKPIYYKRDLFFTRLVVDKVRVDMLGHQLEYTVYYAGTNEGKIHKIVQWTRNGDNQSALLDIFDVTPGEPIQAMALSRAHGSLYAASDRRVLQLRLALCARRYDACVRCARDPYCGWDRDASVCREYVPGLIQDVANETADICDSSISRKSVSATWGQSLHLGSFVKMPEVLQPRAITWYHYSKDKGRHPITFNKPEKYIETSEHGLLIISVNEGDAGRYDCWLGGSLLCSYNITVDTHRCSPPEKSNEYQKIYSNWCHEFEKYKTAMKTWERKQEQCARQNDSNQNTHPNEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBG6</accession>
    <name>A0A0N0PBG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461002">
        <property type="protein sequence ID" value="KPJ10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBG6"/>
    <dbReference type="InParanoid" id="A0A0N0PBG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="12969" checksum="902A4BB900C34E20" modified="2015-12-09" version="1">MRRNPRRQCRVAECELARPTTSRPALVCATTGDWIPVAPPALMTSSGAAIVGPPLPATSSTTPMRSGRPPPARLESSGVTPPPTAPATGGVVRRMRWHLLNESVMRAYFGATEGGTNLTMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBV6</accession>
    <name>A0A0N0PBV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lon protease-like, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBV6"/>
    <dbReference type="STRING" id="76193.A0A0N0PBV6"/>
    <dbReference type="InParanoid" id="A0A0N0PBV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="7">
        <location>
            <begin position="208"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="41281" checksum="3BD21819C1ECA5D6" modified="2015-12-09" version="1">MTDVAEIKGHRRTYVGAMPGKLVQCLKKTGTENPLVLIDEVDKIGKGVHGDPSSALLELLDPEQNANFLDHYLDVPVDLSRVLFICTANVVEHIPEPLRDRMELIDMSGYVAEEKMAIAQQYLVPTARKNCGLSEQQLNLQPEALALLIKSYCRESGVRNLQKHIEKICRKVAYKLVQGEVEHVVVDEAALPALVGKPTFKHDRMYDLTPPGVIMGLAWTAMGGSTLYIETALRSTHQEEKPLGSLELTGHLGDVMKESARIALTVARNFLAQRHPDNNFLNTSHLHLHVPEGATPKDGPSAGCTITTALLSLALGRPARPQLAMTGEISLTGRILPVGGVKEKIIAVLKTKHRIRTGLDWLLLVKTGYNRFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD65</accession>
    <name>A0A0N0PD65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD65"/>
    <dbReference type="InParanoid" id="A0A0N0PD65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="250" mass="29419" checksum="5A72EC678D8886B1" modified="2015-12-09" version="1">MKSIQYRDPLSPVPPTNIKHIKSKNYRELGGLPRYIEKSSSKNRSQTLRLNSASGYLYMNARNDFTLDPEDFREMVAKRREQLRRGVMMYEMRCNEEQYLNPYRNSLSTRMETSPHSSSLYSMNIRSDNRSNDPLVDDYDSEKSSYARKKLMKNIARNTSNKRVENYFYDDAVLHFDDEYAFDGSILFAKRRKSIEPNWDEFACVMPKNPAYEDQISNDGSCGYYLPDDDQQYFVNDTLTFNMPPHRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDF9</accession>
    <name>A0A0N0PDF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460240">
        <property type="protein sequence ID" value="KPJ16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDF9"/>
    <dbReference type="STRING" id="76193.A0A0N0PDF9"/>
    <dbReference type="InParanoid" id="A0A0N0PDF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="724" mass="83315" checksum="0F4D8855B6AC9190" modified="2015-12-09" version="1">MEKTVPVYKVDINTNEFVESQEFNEDNYLEMSNSFSTDNQTIIENNNKETTDIDRQEVDKKDLPNIKEIETNTDKIDSNSEVPEEGEYHSFHDEMDFEEAVYDSPVKKLVEKDIRDYSVPINFFCSDYGRNEVPTYQSPRKCDVQRILEPILEESKSINSDESNNFSCIEQVKIDLNVPKLDKKEETEDIDSNKCLQQEIYEISDKNEAKIKPENLTEENIFRMPNKVIAKDAKIKMQVTDSVRLSYSSIASSEGLSFDSTIEFEKLEIISDIIGIIINRIDFDNIYPNINEVNNNNNDLEITNINKNEISINEQQTFETFSIMDIVKEIERNESFNSTNDSNMQSESHRIVEAIIYYIYDRSFYIASQKNKRKQVKRVITVVDNEDILYTTSPLFLFIEDITAKINLESDCSSNKGDVCDKDINETNKFEPKVVYNKEEFNDNGMKKDSINVLDNKKTTEENIKVPSHIQYNSMVTNNDSIQVRCNDTILENKEIDNPSSIIDNIEVISDKTYVIKQEEEEVEDPLNDTFILDTENEMNTAFLANEFSRSSSPRRWNSVFDLCTESPIKNTGDLSGSDLSLLYERNNTLLGSPFVKQAPVIAMSQTQNRGGLKYWISFDDSLNDVQERCCSKTKKFPDNKMPSFYSLDFNKDGKGEHTVNGDHSDAHQSTFSHSSKEGSPSKEISTEDSPKKDKKKKKGLRTPSFLKKKKEKKKEKSSTPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDG3</accession>
    <name>A0A0N0PDG3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDG3"/>
    <dbReference type="STRING" id="76193.A0A0N0PDG3"/>
    <dbReference type="InParanoid" id="A0A0N0PDG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF65">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2, 6-BISPHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="633" mass="72408" checksum="4428EF6383F5A163" modified="2015-12-09" version="1">MSHEVVVLPLPLPRSLPYLAFAELRAPRRNPSRLHSSSTVHVVNCELSFTQRKHNTEPDIIKSLLMALLCIRGDWYLYIWLIYCKIYSAVVWLVGNHCRGADKRSVITAKAGQSSTGLHRVRTRRKRSQHHRVKHVVALVRRPSLRRIVMAPGASTAHTMMEDKEKALHGALASVSMRSRRISQFAPLLIALVGLPARGKSQLAHRLSRHLNWNGESTKVFDCSEYRRKHMALYGSHDIFRADNQQGSAIRRQSAREAVQDAVLWLKEGNSVAIFDGTNITREQRRELDEYCQTDMGFRILFIECVCEDQELLERNIIEILHYSADYKSMSEEEAVDDLRKKLEHYMRQYEPIDGNLETISFVRVENMGETVTAHKVIGQKESGILGYLSGMRALPQTLYFTRHGESEYNVVGRIGGDAALSARGQLYARALAEHVNALAGREPLAVWTSELRRTKQTAADIRAPKYPLRALNELDAGICEGLTYEEMQERFPQEFAWRDQDKLRYRYPWGESYIDIMTRLRPVLAALEDDHNVVVVGHQAVLRCMLGYFLDAKLDELPYMNVPLHTIVKLTSYGYKYKVEMIKLPIDCVDTHRKQPKNCSINRSTAEALVTVPSHYDTLPSNLWQNSTEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDI4</accession>
    <name>A0A0N0PDI4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chymotrypsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDI4"/>
    <dbReference type="STRING" id="76193.A0A0N0PDI4"/>
    <dbReference type="InParanoid" id="A0A0N0PDI4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857501" evidence="6">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="31573" checksum="1AE42700C12B4F75" modified="2015-12-09" version="1">MVFKFEVILLVLFVSIFGATSYEYGTSDLFIHAESRGRILGGVPADEGAIPYIAAVAVGSTVRSLLCAGSLFTTKHILTVAHCINALYRNGSLVNSLSITVGTNSWNSGGQTYNISGNITHPDFDPILVINDIGFLIVSTDVDLSKSVQLTILSYENIGAGVETTVAGWGRVNRTTPVSSELLELEMTTVEGQQCAKEVKANAAKFRMRVPPVEPRLMLCAYHSVNHGVCNGDSGSPLVEVSTGKQIGLVSWGMPCALGTPDMFTRVSAYQTWIQQTMTISNNTGAVNETKATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDU9</accession>
    <name>A0A0N0PDU9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDU9"/>
    <dbReference type="FunCoup" id="A0A0N0PDU9">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDU9"/>
    <dbReference type="InParanoid" id="A0A0N0PDU9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="11178" checksum="5DCF48CFEF69838B" modified="2015-12-09" version="1">MSSSTQADQANSAFIRRVYSEPPREIKDIKDFLLKARRKDAKSVKIKKNTENVKFKVRCSRFLYTLVITDKEKAEKLKQSLPPGINSLVYIIMEIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDV1</accession>
    <name>A0A0N0PDV1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02797</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
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        <ligand>
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    <sequence length="408" mass="46797" checksum="C3FEB1BD3420F4CF" modified="2015-12-09" version="1">MELSTLILPQNICRTCLAESDSSTFMSVQDLIEHEMNKIKLIDILIFLNCVENNDEENWPQGMCSSCVCTALLSYNFKINCLKANITLSQLFTVQASTSSLQRSDMDSIDINVVYQDHEYDTPLFTNHPVLDFENVSVNKELTPLPPVTEITSTEHPPRKEGDKKYSCTLCPKSFTRIYGLRYHMAKHRGILRFLCPKCGKRFHTANGLRQHLLSHKEIPQFKCGFCNKTYRSRQSLKGHFRVAHSSNQKSFVCVTCDKKFSAKSSLMKHIKIHNGIKDYPCPDCPKTYTRASYLRVHSLVHTGQERPRPFKCKFNECGRSFPTKQSLKVHIAHTHSSERPYKCDICSKGFPTSSGLKVHKESHSNVDTSCEICGKKFINKRVLQKHMKVHYVNDDLILETVVDFFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0N0PEE0_PAPMA</name>
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        </submittedName>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Ya'a_city_454_Pm</strain>
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            <end position="49"/>
        </location>
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            <begin position="1"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="446" mass="49254" checksum="FBD93F095279A0FB" modified="2015-12-09" version="1">MVAFPSVLNPALLSPNSTDITADRNQASWIASINGISGIVGFFILSPIFQSFGRKAVNITLNVVMFVGWITLATASNVTMLFIARAIQGLTVGGVFIAAVTLSEYSTPRRRGYFMTLKKISIGLGSLTCHTLALICTWRQIAGICIIPISLAILFILFWPESPSYLAMKGRFDECEKAFIWLNGNSLESKMELKELINAQTEQHELKKKTENLSQIKKFFRQLNNREMLKACFIVALVTLCIDACGRYFLLAYLTQILEEITGSNTVAMYGSIVSDLLLISALAVSCLVIRLFDRRTLLFGLGSVTIMLMFIISIAVFTKSNYGFLSTVTWLIPCLILLHSFIASVGIVPVAFTISSEVFPLEHRGLCSCISGVAFTIFYAATLKLTPLMIEHTGVSGTYTIYALIVTFCLAILFVILPETKDKTLQQIENEMKGKSDTNSRLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PET3</accession>
    <name>A0A0N0PET3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459805">
        <property type="protein sequence ID" value="KPJ19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PET3"/>
    <dbReference type="FunCoup" id="A0A0N0PET3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PET3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="109"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="339" mass="39397" checksum="33DBACD714FBFDB0" modified="2015-12-09" version="1">MQKTTFDNLLQKLSQELKHQDTFMRESISPAERLAVTLRYLATGDTFTDLYYSYRIGIKTISCIVREVCHYIWLELYKEYMKMPSKEDWLHIASKFQESSNFPLCLGAVDGKHIRLIKPIDSGSMFLNYKHFFSIVLMAVVDSDYNFIFVDVGAYGKECDSSVFKETPFWKNLTNNGLNLPDATRLPGIDYDLPYVFVADEAFALHYHLLRPFGGHQLDQLKRTFNYRLTRARRFVECAFGILSNKWRIFHRPMNVSIDLAVDIVKTCCVLQNFIHKQENFQFHNASENESTLDSESELIQLPITNAVRGSLAANEVRNRFAQYFVSNEGRLSYQNNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFV5</accession>
    <name>A0A0N0PFV5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01066805">
        <property type="protein sequence ID" value="KPJ21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFV5"/>
    <dbReference type="STRING" id="76193.A0A0N0PFV5"/>
    <dbReference type="InParanoid" id="A0A0N0PFV5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="12970" checksum="21DB35E088489933" modified="2015-12-09" version="1">MGDIKEKGEQATKSKRDIIIPRRQASIVIPERVPVYITPDNTTCIECGCFPKDTYVKNKKLLPCLKSPLTLYELSAKVVDNLPLPDAFTWSVEDVADWISDILLAPLGGSTPIPASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I4N6</accession>
    <name>A0A0N1I4N6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen permease regulator 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I4N6"/>
    <dbReference type="FunCoup" id="A0A0N1I4N6">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I4N6"/>
    <dbReference type="KEGG" id="pmac:106719307"/>
    <dbReference type="InParanoid" id="A0A0N1I4N6"/>
    <dbReference type="OMA" id="IVMHKPD"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="400" mass="45515" checksum="4EA0E1A744B8F7DD" modified="2015-12-09" version="1">MDANAKYYEGCGQEGPIRCIFLCEFHHTAGPKITCQVPENYISKDIFDTVSHYIIPKVQLQRCTLTVTLLGSKILGFPVRIDNKKYARNAFYFNLCFVCDAWARTVHLEPLVKKLTEYLLSMELETEWLSKQSMSGDAKDLGCLMKQVMQDINCRRMCTLTVGTTTTHLTVVRVNSDPAPVKDHQVPVFLYSRQSFVADQWDLTTNQILPYIDGFNHVSKIAALTDVEVSLVRACVQNLVYYGVITLVPIFQYCAVYSVTPKLRQLTRCAGLQRQCIEFCARSPRQLPKVNDLFVMYAGMSHGSTVRDLCRRLRPQDLAINERKLVLFGVLEGLIRRVYKYPITLNNVDTASVRSDHNQNLVRTYNGLVCLDELCCHGGLSVTQLEEQLERDSNVVFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5M4</accession>
    <name>A0A0N1I5M4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD and RING finger domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I5M4">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1I5M4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16635">
        <property type="entry name" value="mRING-HC-C3HC3D_PHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15536">
        <property type="entry name" value="PHD_PHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057031">
        <property type="entry name" value="SFR19-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7Q8</accession>
    <name>A0A0N1I7Q8_PAPMA</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Ya'a_city_454_Pm</strain>
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    <sequence length="66" mass="7585" checksum="EBB77DB52EF66AE3" modified="2015-12-09" version="1">MFVAAAESAALWRCKSCGKEVSNRWHHFHSHTAQRSICPYCPATYSRIDTLRAHLRLKHAALLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9E2</accession>
    <name>A0A0N1I9E2_PAPMA</name>
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        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
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            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9E2"/>
    <dbReference type="STRING" id="76193.A0A0N1I9E2"/>
    <dbReference type="InParanoid" id="A0A0N1I9E2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="409" mass="44614" checksum="640F6B7E5BFF784A" modified="2015-12-09" version="1">MEACINEPCSSGDEQRSAGVRVVVLNLPEDEGEGLGFRLTRTLWDPYPWVREVTAGARADLAGLRAGDCLLQADGRDLLGMPVGQVAGLIRGDGTGGGVTLLVWNCGVDPNDDPELLWSCGGGSRGEKSRRALAGVLKALSCCVCAATATKALTCARSHLYCEPCWSRLERCALCRENLPSKDSPYSRNLVAEQVFEAIATEYEIKDTNRRTSKCVSAYTSPERSPNISPTTSRRGQYQLSMMNRSKRNIQSNDKFPSDPNIHRTLSNKHSTLPTIPTKSVDYLSAGNIGNVNCNCHNRLNSDGSQQQINMPQILVEDTEVDNNNCTINCNKTIQHKLVTKLRQACSMADLQNTPVSTCSLSKSLNNVSLGNQCCSNGGHSNSLENFKSNCIAACGKKYLIIFVYFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9G5</accession>
    <name>A0A0N1I9G5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ13988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9G5"/>
    <dbReference type="InParanoid" id="A0A0N1I9G5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="12273" checksum="C03CD13274C256D9" modified="2015-12-09" version="1">MGAKFPFSMENIPRQKRFGCFSLKIGSVFSALVIIIYSVMAIAQCLAILNVLPSNLSQDESEVIASYGVVIFITIIHVTTFVITSLMLVGVLRVRDKYVTFYRTIFHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9K0</accession>
    <name>A0A0N1I9K0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9K0"/>
    <dbReference type="InParanoid" id="A0A0N1I9K0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="17370" checksum="49449CAA9B4B54DB" modified="2015-12-09" version="1">MYALRTAERRRSRSAAALRSLSAAAPSRGDVAVSSHSEMAQRSGGRDAARPRECRHRAGARSERAPNVSQPPTADGIAATKIIRRVSATTGHEATRYSRPGRTQRVGGGVHGAPRPWPRPGSGPSAERRNTLRSHSEPSEKHCRTILTTLHIDRDDSIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9K3</accession>
    <name>A0A0N1I9K3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_02676</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9K3"/>
    <dbReference type="STRING" id="76193.A0A0N1I9K3"/>
    <dbReference type="KEGG" id="pmac:106711888"/>
    <dbReference type="InParanoid" id="A0A0N1I9K3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="511" mass="58255" checksum="05CA04FC39CBA13E" modified="2015-12-09" version="1">MLALALIVVGVVALYLYGTRTFKYWEKRGIKHDKPIPFFGNRWSIYSRTKSITQLAVELYWKYPKERLVGFYRTTVPELVIRDPKLVKQILVTDFSFFNRRGLNTHKSVVEPLLKNLFFVDGDVWKLLRQRITPAFTSGKLKAMFPLIVERAERLQNNAIKVPPTGGVLDAREIMARYTTDFIGAVGFGLDSDSLSDENSAFRKLGIKIFQFDVNQIVRQMLKEMFPETLKHVNVLNKIESDVFGIVRSIMQKRNYKPCGRNDFIDLLLECRNKGKMVGESIELTKPDGTPEQISIELSEALMVAQVFVFFAAGFETSASSTSYTLHELAHHPDVQRKAQEDIDRVLAKYDNKLCYDAINEMNYLRCAFKEGLRMFPSLGYLMRKCAHKYTFPDMDLTIDEGVTIVIPVQALHNDPQYFEDPEDFRPERFLTDFINPLTKDIYLPFGEGPRACIGERLGLMQSLAGLAAVLSRYTVEPAPNTPHPPTVDPTSNVVQSVIGGVPLLFRPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAN9</accession>
    <name>A0A0N1IAN9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="3">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_02352</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="3"/>
    <dbReference type="EMBL" id="KQ460301">
        <property type="protein sequence ID" value="KPJ16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAN9"/>
    <dbReference type="FunCoup" id="A0A0N1IAN9">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IAN9"/>
    <dbReference type="InParanoid" id="A0A0N1IAN9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140681">
        <property type="term" value="F:histone H3K36me2/H3K36me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000048">
        <property type="entry name" value="Lysine-specific demethylase 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JmjN" evidence="16">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="148"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="758"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="871" mass="99182" checksum="B94ABA5887B0787D" modified="2015-12-09" version="1">MSVTSDDVSGGSGSGISIQVFRPTWDEFKDFNKYVQYMESKGAHKAGLAKVIPPPEWVPRKNGYDLDDLNITIPSPICQVVTGKQGLFQQINIQKKSMTVKQFAVMANSAKYCTPRHTNYDDLERKYWKNVTYVAPIYGADVNGSITDPEVKEWNINHLGTILDFVNSDYGIEIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYAIPPEHGKRFERIASGFFPTSAKTCQAFLRHKMTLISPQILKQYAVPVNKVTQKAGEIMITFPYGYHAGFNHGFNCAESTNFAAPRWVEYGKRALQCTCSNDMVKISMDTFVKRFQPDRYELWLKGEDVGCHPEQPEKMVPAPHPSGQDILCNKNNTELPESFIEAEIEGLKKKKRHPLHLKRAMASKSISEGAIAVSILGHDVMDDDEMTMAEGDLDMMTSMKRQMMPLSPNDTQLDALEDIWLKGDEMEPSEAQQPDVGYMDSDKDSDYEDPSVKRITKPRKKRKESIKKEPKEKVKEGDEETITKSKKTPPVNRTQKRKINTKKLSEEQLQDMAAVISNWESPPHEDESTKTTKTEPVSNPILKSLLNKDSSSPSKDKKEPKKRKSSLKDTEQVEKQKHEKAKKEKKKEDIVKKETSTDNKTEKKPRKPRTPKKKVIVEYNNAPETFIPSQTATRALDLDTKEAKDTKEIKKTDRDSSVASSSKSPVLPKPSLPTEIYSGLCVGAKPRQTTISPINKNPTAFQGEFHKFMVTAKLKPEPLPLPTMRIPKKKPPKTKYTEPTRTVPTPVLTEPPIPKCQYNDDIFVNRPLDFRMNSIPPGPQNVPTRAEPIVQPQFRDEYSAQHTLLQNVQPNYGDNSNYYRSPYQTPWFGYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG64</accession>
    <name>A0A0N1IG64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette sub-family A member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG64"/>
    <dbReference type="InParanoid" id="A0A0N1IG64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="PANTHER" id="PTHR19229:SF241">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="37"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="37328" checksum="261AB1A1F7D8C735" modified="2015-12-09" version="1">MSERMEDLRQILISFLDMEEKKGQVHEVSVGEVAACVRLGKVYPTLAGHRLALRDLTLAIPSGQCTALLGQNGAGKSTTFSMLTGEVRPSSGHICLRNIRARPTDLCKGFISYCPQSDAIDPLLTVRETLKFYCRLRGIQEQDEVIRRTIETFDLTKYRDVRSGLLSGGNKRKLCTAIAFMGRTPLVLLDEPTSGMDPGSRTCVTRGVQRACSSGRGVLLATHALDDARRLAARVALLQAGTLRALAPLHQCLRSISLRQLDGKEVHTRVSEVFRLTAELHAACDIEDFTVNQSSLDQMFLQFAGSSRSRGTELEEQESDPAPPTTAPPTLNCDVSDITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGB7</accession>
    <name>A0A0N1IGB7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Src substrate cortactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460869">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cortical actin cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hs1_Cortactin"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="115"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="30141" checksum="250E86FAD191D8FD" modified="2015-12-09" version="1">MTCEIRPIVKYGFGGKFGVESDRVDKSAHRFDEVGKVGTNYTKQKPDIGGAKPSSIRAKFENMAKEKEQEALQSVQKIRQERQMMDKELTQKEKDKVVVDKEDEPQIQMQKEEPKIIIPKQIQRETTTEAVKQIEEKIETEKRELKEIQNQEEVKLTNLPDVTLVGEGTEHKEEKEESRQPTIVVSPVGWEGGEGGEGEGEGGEEEEDGYTARALYDYQAGAPDEISFDPDDLITNIVMIDEGWWQGLCKGAYGLFPANYVQLQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGC4</accession>
    <name>A0A0N1IGC4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhophilin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460864">
        <property type="protein sequence ID" value="KPJ11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGC4"/>
    <dbReference type="FunCoup" id="A0A0N1IGC4">
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IGC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06712">
        <property type="entry name" value="PDZ_rhophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
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    </dbReference>
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        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="594"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="747" mass="84937" checksum="1A9AB0380CC8A798" modified="2015-12-09" version="1">MPMIPLGLKETKEVDFREPFKDFILEHYSEDAAAYEDAISDFMDMRQGNSLYVHTIKFTGVPSCQRTVAFEKACVLFNMAGIYTQIGAKQERTTCSGLDGAVDALLRAAGALRYIHENFTNAPSVDLAADTLLVLGTLMTAQARECLFEKLQLQAREARGEALPADLDMCLDLAQESAQLAHVYKQLYDKMQTEGVFNYVPYSWVSLVHVKTEYEMKGFNSLLGSHYDHYYLDYRDYNVEDIDPNVFDVDRNMKCTSFPGPGSRHFATFNPMKEFVHPVHNAHVDNEFDRFKTKHNKKYASEIEHVKRLNIFRQNLRYIHSNNRARRGFTLAVNHLADWAEDELSALRGRRYSGPSPLGSNNSVSEVEPIALGRAHLAEALALYEEALRLQRMCRELRGKEALSRCVTAQRERAARARGGREEPDFADIIDAPAILPASKFELALTPPDFAQHRVEDLFKSLGPIAVFSAKRHWSAPRLIQLQKNTEKRREARRDRRNGKEEDKLRRRPSDKRDHSEDNSTYYNQIRDEKILDEKRVTKQNGVYINSYNNNNYDYHHKVIEYDRYEYEMEKESKLKNGRERERKELRRVASEYNMANNKDDEGFGFTVRGDAPVVIAAVEPNSLADIGGMREGDFIISIGETDVKWSSHGEVVRLIQQAGPALTLRLATPMDTCHKPRVRGNEVGGQRGSQQGSVSGASSASSGSTATSGRTPRSHSPRSPRRAPSWNPFRRAAATLSHNHINLTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGS5</accession>
    <name>A0A0N1IGS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGS5"/>
    <dbReference type="FunCoup" id="A0A0N1IGS5">
        <property type="interactions" value="1372"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGS5"/>
    <dbReference type="InParanoid" id="A0A0N1IGS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="433" mass="49360" checksum="88E68221D8B76151" modified="2015-12-09" version="1">MNSNINTMYGSAICKACLSIDRKLTAITDAENLKIYCNLLEEVQEERKKALESDSFKKMLYRCYDCVLGFNHRFKLDNHMKKHQPEYGPEVCDICKIRCKQASALSAHKKRHQVKWRCSACGGAWSRASVAADHVSRAHHAANPTHQCSLCTQHFPTLNKLRLHMKQHSERVKCDQCDKTFVDRSAMRNHLFIHIGDKEFSCPHCDKKFLFKRAMEVHRATHDPDARIYCHSCDLSFKNEMSYKQHMLYSLKHVDPARLKYACELCDKRFVKAKRLEEHHIAVHLKATPVKCTAPGCNFACSSRPVLRTHTRMLHRNVRARRDHVCHLCGKTYTSKAALQGHLRAHSGERPLRCARCPAAFGYPAALYNHTRLVHLGHASGKSKTNEVSQTVTTATDATLAPLTAEHPDTKSMWNSLTPTVEILQQPIETLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGU0</accession>
    <name>A0A0N1IGU0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459887">
        <property type="protein sequence ID" value="KPJ19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGU0"/>
    <dbReference type="STRING" id="76193.A0A0N1IGU0"/>
    <dbReference type="InParanoid" id="A0A0N1IGU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="439" mass="48423" checksum="CEF5DA2BEFC8D71F" modified="2015-12-09" version="1">MPLEEAVKLFGGAEISEVRAISEKEEVIVEGGPVSGPEHPLVDLLSSFRSSLNAMDHEGTTISQGFIQEEKSRSLLWKIEKERAYASENCPSCAKSLSVQVTFETATLQTEKIPAARLRLEALAREVQESYCHHQHTALMTYYQIEDLVYMTIQSGMGEIREALSLLLQAMRLSDGASEVYSASLQRWVVALAAKLLYTRDLRHLIFLIHHLFRQNRSVRWASRVLRVQVTDVCSAARAIALLELILARPGLETAVECTEELVEGWEEVGRSGEGSAVGEGLLRERDALALLRALPLRQLLAKMALFNRSDIESTEEHEWGDGSGGHGVLKAACGARALLAVLQRAVHAHAHYARLQRELTELCACALQLDIESTEEHEWGDGSGGHGVLKAACGARALLAVLQRAVHAHAHYARLQRELTELCACALQLVAALHLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHJ4</accession>
    <name>A0A0N1IHJ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHJ4"/>
    <dbReference type="STRING" id="76193.A0A0N1IHJ4"/>
    <dbReference type="InParanoid" id="A0A0N1IHJ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="309" mass="34392" checksum="AA854E3CC9D515FC" modified="2015-12-09" version="1">MGRPYCPQNGRLMGPQNETQWPNQCRSGGQQSPINIMTRNTVVDTYGAHIRGPLVFRGFGNVNLRATNTGRTLKWMVEEDGPAPVLSGGPLRGNYTFVQFHLHWFSEHAIDGMKYPMEIHLLHVKTGLTVAEALKRPDGLAVIAVLCRVFADDEDNDYSLHELADMVPSLQNRTTAGSELPITLDLYRLMSAQRQAYFTYHGSLTTPDCQEVVTWIVQEQPIIISDSQYKLFRQVDVGGVDNYRSLQPTNRIVYRSAGSSLYNPSPIGMLGALLSITSLLKSTVGSGICFITNLKRKFFTDSSNTCKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJP8</accession>
    <name>A0A0N1IJP8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase</fullName>
            <ecNumber evidence="2">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ459850">
        <property type="protein sequence ID" value="KPJ19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJP8"/>
    <dbReference type="STRING" id="76193.A0A0N1IJP8"/>
    <dbReference type="InParanoid" id="A0A0N1IJP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="9907" checksum="788B1E93FF8A78F0" modified="2015-12-09" version="1">MEKHGIGTDATHAEHIETIKNRSYVALADAVHFVPGLLGMGLVEGYDAMGLNMARPHLRAQLEADLKAISEGTKQPDIVLAEQSNRSKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJW8</accession>
    <name>A0A0N1IJW8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01451</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ459762">
        <property type="protein sequence ID" value="KPJ20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJW8"/>
    <dbReference type="FunCoup" id="A0A0N1IJW8">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IJW8"/>
    <dbReference type="InParanoid" id="A0A0N1IJW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="458" mass="52879" checksum="05C85F77026CFD07" modified="2015-12-09" version="1">MESALRKKNIALVMHKIYQDYPKEKLVGVYRMTTPCVLVRDLEVIKHIMIKDFDMFEDRGIEFSKEGYGANLFHSDGETWRALRNRFTPIFTSRKLKNMLYLMTDRGDKFVQGVEKIIKEQPEQAVLKHIQLYTIATISACAFGIDIDKLGKTLDSLYKLDEMALNTNFFSELDMMFPGILKHMTYTIYPALAREIFDGLIKNVITERNGKPSNRNDFIDLILALKEKGEIEASKTNTEEKIKPLELTESVMAAQAFIFFLGGYETSSTTMTFMMYQLALNPEIQNKMIEEIDEVLERCNGEVTYETLNELTYMEKVFDETLRMYPIVDPLQRNAKNDYKVPGTDVVIKKGQTVLVSPRSVHYDDQYYPNPHKFDPERFSPEAVGERHSCAYIPFGIGPRNCIGMRFAKVQSRVCLLKFFSKFRVEATNKTPKVIEYDPRRSTVSPLGGIPLNIIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INR3</accession>
    <name>A0A0N1INR3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein giant-lens</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INR3"/>
    <dbReference type="FunCoup" id="A0A0N1INR3">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1INR3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021633">
        <property type="entry name" value="Argos"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11581">
        <property type="entry name" value="Argos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874065" evidence="1">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="277" mass="31525" checksum="AD32B0311526295F" modified="2015-12-09" version="1">MRVLATLLMATVLGVVRGVIRTPLEAFRPSGEIHLKRPDKLPLLPHRRTAMQAKSGLKILYQIGTSEEDLPECRARQVCSKADLYDATQPWIERKCRCLGHKPCSSELSADDNHTLSDKTTLYKTCEPIKRLPKCRYFKDAAWTIYSFPDTNATQQIVNCHCPKASMTYLLKKLSYTTASGELGNQYQFACSPLSRLRCSRKEPCKLFSVRRRHEQIDEVNASTICQCPRDHTCPRHHTEPGVLPGVTYAAEDIRTYHGYCMPEPTLDTYRFVGDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP61</accession>
    <name>A0A0N1IP61_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich protein 2-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460731">
        <property type="protein sequence ID" value="KPJ12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP61"/>
    <dbReference type="STRING" id="76193.A0A0N1IP61"/>
    <dbReference type="InParanoid" id="A0A0N1IP61"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="15601" checksum="1BC0ECED6B48B46F" modified="2015-12-09" version="1">MEVEVNNAVEFPDSDQKPSTFCKYCLNPENKQDNPGLRCEICNGFVHLTCLRRPGTPGDFACDVFFEFVCVECSDNKEEVFERKRFQWVNVLLLTLHHLSIQSYGISNNGFFHYKTHICSFIDRNWVLLFGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP98</accession>
    <name>A0A0N1IP98_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP98"/>
    <dbReference type="InParanoid" id="A0A0N1IP98"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="20877" checksum="1F30FA2FA4E5BED4" modified="2015-12-09" version="1">MIPTRSGKKFLLMINGYTYSQINYSAHWLCSSKALGCPARVKKSAKGDIFKVNTVHTHPPPKYIYVQFIPTEKGKYILVLRGFTYSQVGGRFFYCSSKHMGCKARVRLMGGKLLPSGDEHNHAPPSHARCGNGAFVQLRPPNSPHPVLPSPVSSPRAALLALHALNFPRIMPKTDLWLRLPADAKKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPL3</accession>
    <name>A0A0N1IPL3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPL3"/>
    <dbReference type="FunCoup" id="A0A0N1IPL3">
        <property type="interactions" value="1282"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPL3"/>
    <dbReference type="ESTHER" id="papma-a0a0n1ipl3">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106711094"/>
    <dbReference type="InParanoid" id="A0A0N1IPL3"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="58"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="313" mass="34641" checksum="08439A7047E5B0C7" modified="2015-12-09" version="1">MFLNKLCHKNILQQIKIPALSQIAISRPSSSTDSSISETVDLAYASYESTSDESCSRPPLIILHGLLGSKNNWNSMSKAIHRTTGRKVISIDARNHGDSRHSSQHTYIHMAHDVMKLLKKLDLSKVSVLGHSMGGRTAMVLSLLCSDLVSSLVVVDISPVKTSPQIYSMVSLFDAMSGVSIRSGIAMSKARKLADEQLKAIIPDINLRNFLITNLVQTNTGSYSWRVNLPALKDNFQSHISCFPNNLKGLQYCGPSLFIGGSLSDYIGKYDLPEIQEYFPLAELTFIEGAGHWVHSQKPEKFLEVVCKFLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPV2</accession>
    <name>A0A0N1IPV2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPV2"/>
    <dbReference type="STRING" id="76193.A0A0N1IPV2"/>
    <dbReference type="InParanoid" id="A0A0N1IPV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="700" mass="78450" checksum="CAD5CCC4C968FB0F" modified="2015-12-09" version="1">MFVSQDKNVKKKFQKPNILRRKTKTPLPRPQATSECFESPDGKSLVSSSLVDKSFNAHEGPNKVAKQIVIKHREKPNQLFNKSTQKLISASLISEDNSSTAVVKKENDSDITFTIITTQENNNEGNFVQTGVNVDSFLVGGASKQNGLRFVNTELQIESVDKYDNTKWCLDLVQDLPTEIKEHCDGSQKKNVLLEQKLDVTPTMVPLSVVSSVQRNNIITLQGEVVPIMTNVLNSTFDLNKSKAKFKCEVADCDKEFSNKQKLKKHQNSHKVGSTRPPRQTNVECPVKIFRSGVEEPCGQMFTSREDVLKHLNENHTLEQANYICTECGRRFFWACALRAHRQAHGRARRGVLACAWPGCGRVFRQPCRLREHTRAHTGDKPYPCKFPNCGWSFRTASKLVRHARRHTGERRHACSACGRAFLRREHLREHHARHQPPLARHPHTCTHHGCEQSFNNMSSLYTHMKKVHKKEETSALNTSTEPVFENTFTISMLKNDPIYESVPNIEISLLKNDPIYESVPNIEVSGNLKLEQVTDSNEVETKMEVLTEDMEGTGEEMLGEGGILGETDEEVEGECQSARTHCTWPLQSRAPCDYHCGDAYVLDEDVQVEQSESAESNIYTIRSDLFLHGNALNEDSEGGMGVGVGVGEGVGAGGVSALGDDLGLLDSHPTIDLMQEELLYTDAVDESSFRVFLLSEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ40</accession>
    <name>A0A0N1IQ40_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">YY1-associated factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ40"/>
    <dbReference type="FunCoup" id="A0A0N1IQ40">
        <property type="interactions" value="1497"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ40"/>
    <dbReference type="KEGG" id="pmac:106721089"/>
    <dbReference type="InParanoid" id="A0A0N1IQ40"/>
    <dbReference type="OMA" id="TADHHSQ"/>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000009">
        <property type="entry name" value="YY1 associated factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF4">
        <property type="entry name" value="GEO03726P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="14707" checksum="01089CEEF5A6ED31" modified="2015-12-09" version="1">MDKKNAIRRAKRPSKALEENYWDCSVCTYRNNAEAFKCSMCDVRKGTSTRKPRINPALVAAQAAGSSQKRPRSTSLKKKRRHPPRLSNVDRSSAQTREVTVSGVTVVITEYKPKKSVSSSSSDVESSNDTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQF2</accession>
    <name>A0A0N1IQF2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQF2"/>
    <dbReference type="KEGG" id="pmac:106707964"/>
    <dbReference type="InParanoid" id="A0A0N1IQF2"/>
    <dbReference type="OrthoDB" id="6627399at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF9">
        <property type="entry name" value="OSIRIS 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874223" description="Osiris 16" evidence="2">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29625" checksum="BE2713F38B00660F" modified="2015-12-09" version="1">MFKSLLTTTAFVLCAYRINCSIHGSTSNEIQIEKTNTSERSGRSLNKECNNSLNAKCIKIHVLSFLENLSSKDELTLLPGLSIVKENYTSNTSPEEMAAELSRQFPGKPEEKLNRFLIYRLQDYLDGHSLRYKLLDPKTSQEALEMANGDGESVGRKGGGGGLGGGGKGGGGGALLAAALMMKGALGAAALGALALLAGKALMTALMSLLLSALVGLKGGGGHKSTTYEIITKPEVSHHHSHSHEEHHEHEHGHHGGYRRAYDADYNSYMPYDNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQM9</accession>
    <name>A0A0N1IQM9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing regulator female-lethal(2)D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01008123">
        <property type="protein sequence ID" value="KPJ20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQM9"/>
    <dbReference type="STRING" id="76193.A0A0N1IQM9"/>
    <dbReference type="InParanoid" id="A0A0N1IQM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14677" checksum="1000A6359636884D" modified="2015-12-09" version="1">MAKCRLLHQENEDLGRMTSSGRIAKLEGDLALQKSFSEEVKKSQSELDEFLQELDEDVEGMQSTVLFLQRELRATHTTVNGNRPSSPPDKRTYSGSECSDTPVGKRRRASVLSLDYNEEEEPLTVTNGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGE3</accession>
    <name>A0A0N1PGE3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N1PGE3"/>
    <dbReference type="KEGG" id="pmac:106711214"/>
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    <dbReference type="OrthoDB" id="8038273at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26703" checksum="4BCAA809A05FC9E0" modified="2015-12-09" version="1">MPKEFKYDVVLLIESVRDRPCLWDKSLENYKDRVERRAAWEEIFSILDESYEEMSPEMKRITGELILNKWTNIRDTFVKTLKTRMGKPKKKYLLHEHLKFLTKITPEEHSSLDLYNPDVPISYFKLEKEEKVKPSYSRKRNKQLEECEMILPKKSSVFDASNDLDFVGVDESNDPRVMNEDEAFFASLLPTVVKYNEDERLEFRMEVLAVMKNIKDKRKCSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGM3</accession>
    <name>A0A0N1PGM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460784">
        <property type="protein sequence ID" value="KPJ12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGM3"/>
    <dbReference type="FunCoup" id="A0A0N1PGM3">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGM3"/>
    <dbReference type="KEGG" id="pmac:106713872"/>
    <dbReference type="InParanoid" id="A0A0N1PGM3"/>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="31888" checksum="9545795AC3E1F5ED" modified="2015-12-09" version="1">MKAIHAMKRFCGTSMFYFNTCCHQRLSKLQVRHSVTVGTLKLKKIVPDLVNIRNLGLGPTSKDFEEPTQISGPLTKVHATELVLHLNDEERKVLFNALQEYESNRIKEEFEDKLAGQRWRSKLGRPSKVPTLGDVDPTGTYCPVPEDWLKKKYAATVPKPTTKELLHLSLANSIPFIGFGFLDNFIMIIAGDSIESSMSAYITLSTMAAAALGNTFSDVIGIGSSYYVERGAALIGLGAPALSPVQLDMPVSRRFANMGRVLGITLGCFLGMTPLLFKDDEKKTDAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHZ0</accession>
    <name>A0A0N1PHZ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase PRDM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1PHZ0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <position position="58"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <position position="61"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ14005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="470" mass="54643" checksum="39E5A20CB8F9ED26" modified="2015-12-09" version="1">MVDISVVCRTCMKNDGDLVNLFVPMKMEHNCEMLYVDALMKASTCQVTKEDGLPQNICKDCANILQILITFRANALKTEDNLKKLIFFGNTLKEELKDEDENNTYEKIEICENAILPKIEKTEEDFYVCPTCGKQYTHHKNYLNHMVTHETENTEVKLETDFDSIDGILDDTDLSETIYKCEECNKIFNKERTLISHRRKHENYLTNKKTFQCDYCNKIFTMKSLLKRHLKLHSTNRPFPCTQCSKSYTRQDQLIEHIKRHDKVKAHVCSYCNKGFAQLCTLKEHLRVHTKEAPYLCSECGKSFTNNSNLRQHMKRHSGIKPFSCAFCPKTFSTKGVIPLTPRFNCKDHLKRHQRIHTGEKPYRCRYCERAFSQSNDVIKHMRMHVGQDIYQCSVCHMKFRLMRDLKHHYPIHYINSSNAPTVPVGNGMVAPIMVLKTDTDVQNVTQTDIMITVNDGLSNGIIINTQQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHZ9</accession>
    <name>A0A0N1PHZ9_PAPMA</name>
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        <submittedName>
            <fullName evidence="4">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">RR48_03926</name>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460635">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="152"/>
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            <end position="213"/>
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            <end position="330"/>
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            <end position="381"/>
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            <end position="416"/>
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            <end position="452"/>
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            <end position="523"/>
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            <begin position="147"/>
            <end position="519"/>
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            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
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            <begin position="536"/>
            <end position="547"/>
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    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="562" mass="62717" checksum="EA58135F5A6C7F1C" modified="2015-12-09" version="1" fragment="single">RYSANWVDNFNHTRLHRGLCLKRSCAEHSPPPLSRPSTHEELQAWFSSCVNATMQRGYNLRAHLYQLDYCKTSAARSGGPLSASEKGFAAALAAVLALAVVSTTLDLALSDDAKKSAGWALSWSLRQSWRTLTAPPPTPADCDLRIFDGLRVFCMFCVIIEHVCWLSTLSYLADTRFTEQTRRATDVMLMTNSTLVVQIFFIMSSFLLAHKLLQDRSHLPPIRTFIQTMFNRIISWWQRLGHGPQWDPLVGAEAQICRNKWWTHLLYLNNVIYPDDKCLIQTWYLAADTQLYALALAMTLLLRNRRGTTVVLATLLLIATGVTFALAYIWHLVPTFIVHRPELVRAIYHGDASFNVLYQSPLGNAAGALCGLLLAHAHHALRRAGLQPQNCQVFRWVSVCAAPVALWWAALSPLLVPAGPPPRAAAAALAALERPVFALLVIVALLGAINGVKSPWRTWLSGRGWAICARLSFGALLLHMPLNKALLASRLTPIQLDRQNAIFEWFGVAAISYAAALPLALLVEIPVQRLHRELTKSQHKAKQERPPQHVQLTQKPEKTDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI17</accession>
    <name>A0A0N1PI17_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460501">
        <property type="protein sequence ID" value="KPJ14165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI17"/>
    <dbReference type="InParanoid" id="A0A0N1PI17"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="57484" checksum="84E5B46F565BC0DD" modified="2015-12-09" version="1">MFVSCLLDLRELRSTDRRQRKTSLEISRAKSQHRLWTPEPSLVALEVGHHGDIVGQTPHNLSPTQGTLFIMNFVFVFVFLGAVRAQQPSSPSSLSEQSKQYLDRLNKLLGPVPTRKGPVLFPPSPPDPPANTAATSKPDAESVNTFQQNYFARLTHYKPVTLATLTPETLAPRIGSVDDYVYDQAPYTDIEKKSIGNNFDSNYHQFETRTALPPIYHAIAQNAQLTTQRPYPVYDYQSKIHVNENNYNGDISEEGKNTENEKDKSYAFSYKVKDQKTGDDFSHSQQSSGSATNGEYRVKLPDGRTQVVSYTADENGYKADVRYDTDNPNSIEYNFDSRNNKDYNYNAPIYTKINDYQTPSKLDYKDVSKEYYNDFSAEYNNYEPHQSKFAIQFDGNKNDALKDLNQYLTSTIKPNYLELEDVLSKALPNVQPTFNYYPKENTENIVLIGNRNTFKSNPSDLSFINSTPRNYLVSTIATLRDRVTSKPILSDSFIKRINKYLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI48</accession>
    <name>A0A0N1PI48_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI48"/>
    <dbReference type="STRING" id="76193.A0A0N1PI48"/>
    <dbReference type="InParanoid" id="A0A0N1PI48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="57"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="524" mass="62139" checksum="7AF408C84458DF93" modified="2015-12-09" version="1">MAAVHIGVFYILLHAWSQHKHKTVIYRHRGVNLSKVIVHIDLKGSPPKLEYLTSLLPLLKDIGANGLLMEYEDMFPYKGDIGNLSSKYCYKENELKKFIKFAWKSGFEIMPLVQTFGHMEHALKLQEFKHLREIPMYPDSICPSKMESMALIKNMLQQVIQFHTSVVPLRHIHVGCDEVYHMNKCAQCRSRRQKEIDIYMSHLQSVTDIVKLYSPNVTVLFWDDMLRGVDSNYWSTMKSMNDVEPVCWDYATMLHVSHRNLYNYHKKFNNIWIASAYKGAEGVTATLPDLYSRFMNHLEWLRFIFDYKFGGERKSYNFKGIILTGWSRYSHMEPLCELLPASIPSLVMNLLLIKHFQKETSKDVHSIPAAEVFHIYVRDDFKKYFHCEYAELNEFDTHACQYRESKLYSSLEYFIYQNEDIIRKINDNKKGLHSIEYYNKIDHLNMNSIKSNIIWVNESLQDFIATESKVTKAMLEYHNSFVVAEYVHYKFYNEKKKLKSLLKILKDYYKSHTWHRKSYKNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PID0</accession>
    <name>A0A0N1PID0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative threonine-rich GPI-anchored glycoprotein PJ4664.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PID0"/>
    <dbReference type="InParanoid" id="A0A0N1PID0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879845" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1409" mass="154403" checksum="733B57E05AB705BF" modified="2015-12-09" version="1">MATALVVLLTVAVAAASPAPSMLLLDSTTLAEDVTYEVTATTLIPENDTVVEISTIVADDDIGSASVSQAGLAGQAGQTGDGEWRCPRGCDCAALAEGTSYNCSLPSGVLAFDEYGDGITFKCQSGVFRCAEVPLAASAGRRPGRGALQAALGSVTLRGCELPAEPVTCALTRRGARTTAKLIVQAPRTPLDPVHLRGLENLEMLRITDLERRVRPGETLHYDTPCSASTPSLPILCPSRAEGTPRTMTTQRAVTCGRSSEGARTELPLRALGAVPRLRQLTVNEAQLELKTPLPALPLLALELAADALTALPPRAFRALPSLRRLGLWANALADLPEDTFEGLEELRELSLSQNRLTRLPATLLQRTPRLERLDLYANHLRTLPAALLANLHHLVQVYTSLHLSAPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSPDEVAGDAAAAHAAPRAPRPLRQPPAHSACSPARQPAPSRAGIHLSTPLCTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHFSTLLYTSLHLSTLLYTSLHLSTPLYTSIHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSTPLYTSLHLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIG1</accession>
    <name>A0A0N1PIG1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIG1"/>
    <dbReference type="FunCoup" id="A0A0N1PIG1">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIG1"/>
    <dbReference type="KEGG" id="pmac:106716078"/>
    <dbReference type="InParanoid" id="A0A0N1PIG1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="274"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="544" mass="62381" checksum="8C9294470E5B0CEC" modified="2015-12-09" version="1">MVKRCESSEEGRCGVQADVIVLGRSLPGIVTAHKLKMRFGDSLDVVVIDLPRPPKGVSKIDMVTFYDDDDNADEIDNNATQQNLDSYSRRFLLMYAKEFKISIPDEVLNPLNVPHTHNKVFEHTNGSTVPCNNNFHDFEYLTVLEKFELNQYQRLIDEHMINLFCVSKTPSASERKQLLYFDRTTMERHICGALLFPTSREIMRSIVRLVCGVSPSSVSVLFYLHQCYRNDGCRDYIDGNNMKLREKLLGYYRKLLAHKLQESVADITLQANSIKNIRTYSHEQVILETRDEDTYVCRLLAMALRPDELHDIDVEPLLLSPRHADIVHFMLPGRLKKFKIRYETDFWRRDGFSGEILSIRGPIVWAIERPMLSATGSKKRLACLVGFLKAVKYELHKHDSKAEVIEQLVKLFGNDAAHPVNYRESDIEDLFVPRCGDYVALKKWTEEENVRFVEWGTLDMYRDGDISGALEAGHSAYLRVSSQLRPQGATYEEVSAVDIRTNVYGNFFTRVTSKVNFVSGLSLVAYTAAIYVGIRLIKSYMNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKS0</accession>
    <name>A0A194QKS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKS0"/>
    <dbReference type="InParanoid" id="A0A194QKS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8922" checksum="592B3AEC8B9EA5AF" modified="2016-10-05" version="1">MKDSAPRCEDVADKLVRLFGWRQTYPVEKLQRNLLPKNSEGIWWVFEPWHCGRTKPFPVYSDARQFMPARPTDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLU4</accession>
    <name>A0A194QLU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLU4"/>
    <dbReference type="FunCoup" id="A0A194QLU4">
        <property type="interactions" value="1701"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLU4"/>
    <dbReference type="KEGG" id="pmac:106719834"/>
    <dbReference type="InParanoid" id="A0A194QLU4"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007430">
        <property type="term" value="P:terminal branching, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="39510" checksum="1FFD63EAFFE71CE6" modified="2016-10-05" version="1">MKGCIFNIDAGYLEGLCRGFKCGILKQSDYLNLVQCETLEDLKLHLQGTDYGTFLANEPSPLAVSTIDDKLREKLVIEFQHLRNHSVEPLSTFLDFITYSYMIDNIILLITGTLHQRPISELIPKCHPLGSFEQMEAIHVAATPAELYNAVLVDTPLAPFFVDCISEQDLDEMNIEIIRNTLYKAYLEAFYEFCKQIGGSTADVMCEILAFEADRRAIIITINSFGTELSKDDRAKLYPRCGKLNPDGLAALARADDYEQVKAVAEYYAEYAALFEGAGSNVGDKTLEDKFFEHEVSLNVHAFLQQFHFGVFYSYLKLKEQECRNIVWISECVAQKHRAKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM43</accession>
    <name>A0A194QM43_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deltamethrin resistance protein prag01 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM43"/>
    <dbReference type="InParanoid" id="A0A194QM43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031973">
        <property type="entry name" value="Deltameth_res_prag01"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16020">
        <property type="entry name" value="Deltameth_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264475" description="Deltamethrin resistance protein prag01 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Deltamethrin resistance protein prag01" evidence="3">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="17711" checksum="FE4A940AF2297CBC" modified="2016-10-05" version="1">MLTYRWTRSNALSQLMLVLYISVNSSHCKSNYVNYSFSFIFLNEVKKMRSKILSFQRQFIGVFSKRKYCNSVDMRRDAHMNELPVPCIPWEPWYTEKQRWYTRFLTLSIAWWLFSFGMAIYTDSIYLNWGPPGQPGPPSDMVDECVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMC2</accession>
    <name>A0A194QMC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMC2"/>
    <dbReference type="InParanoid" id="A0A194QMC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10465" checksum="B2D354FD1183AB96" modified="2016-10-05" version="1">MWKAIINRKRKYSDVLPCDQESSYAALAAMQGGNSSTLPPSLDALRASNNIPNGRACDTVPISPYKCNKPRETGPNGSRESAAAKKNNWSRSETDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNS0</accession>
    <name>A0A194QNS0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNS0"/>
    <dbReference type="FunCoup" id="A0A194QNS0">
        <property type="interactions" value="1731"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNS0"/>
    <dbReference type="KEGG" id="pmac:106719146"/>
    <dbReference type="InParanoid" id="A0A194QNS0"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24033" checksum="24C852ED494FF04F" modified="2016-10-05" version="1">MEPNPVIIAATAKQTASLIFLHGLGDTGHGWASTIAAIRGPHIKVICPTASTMPVTLNAGFRMPSWFDLRTLDATAPEDEEGILRATDLIHGMIEDEIKSGIPITRILLGGFSQGGALALHAALTYPETLAGVMSLSCWLPRHAHFPGAVKAPTILPIFQAHGDCDPVVPFKWGQMTASFLKTFMKNIEFNTYQGLTHSTSEEELKDMKVFIERMLPASAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ25</accession>
    <name>A0A194QQ25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RING finger protein C548.05c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ25"/>
    <dbReference type="FunCoup" id="A0A194QQ25">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQ25"/>
    <dbReference type="InParanoid" id="A0A194QQ25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="15657" checksum="1A47B6DAE6D51A33" modified="2016-10-05" version="1">MTDHDEDVVDLTISFTLADHCNLANEVIVIDTDDSFEASNVRAKKSNKPKKSLRVRKSSANTTTSPNEKCVANMKRKSNQIGSCPICWEELGKNPLVSTKCGHVFCLKCLERSLKVEKRCPNCRIILKGASAYHRLYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQA9</accession>
    <name>A0A194QQA9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQA9"/>
    <dbReference type="FunCoup" id="A0A194QQA9">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQA9"/>
    <dbReference type="KEGG" id="pmac:106718701"/>
    <dbReference type="InParanoid" id="A0A194QQA9"/>
    <dbReference type="OrthoDB" id="5567844at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="107" mass="12022" checksum="D062254004C36BBC" modified="2016-10-05" version="1">MTSASSSSARSLFAESKQRLAERVQVNMNNISSLARQIQRGSKSNELSKAARDMAAVEHVMENSEENLKKMQLIGIHIGYQFENIQKSAEMIVEINEQVASIRRPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQB0</accession>
    <name>A0A194QQB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQB0"/>
    <dbReference type="FunCoup" id="A0A194QQB0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QQB0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="224" mass="23588" checksum="1368200AAD7B20F9" modified="2016-10-05" version="1">MRTNGYKGRGRQKKVRMDGVKKIASFHINTLRQTQQASVTSTMFKFVVLSALVCAAVAEPGVFLAPSTYTAAIPAPVTSTYVQQSSAIYPAAVPSIYSGLSYPHFIKKREAQFYNGYIANGAYVAPAALATPYASTLVAPAGLAAAYSPAVLPYAAPAHFIKKRSASASPQLLAAPLTSTYVASAPLASSYISSAPLAATYSAPIYSSAAYYPTFSTGFPFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRJ4</accession>
    <name>A0A194QRJ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">28 kDa heat-and acid-stable phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRJ4"/>
    <dbReference type="FunCoup" id="A0A194QRJ4">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRJ4"/>
    <dbReference type="KEGG" id="pmac:106718158"/>
    <dbReference type="InParanoid" id="A0A194QRJ4"/>
    <dbReference type="OMA" id="IDMESPR"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="19547" checksum="E6D056EB5BC32AF2" modified="2016-10-05" version="1">MPRGKYTNHKGRNRKFTSPEELEEQRKQEELKQKWRKEHGPSSSEEESEDNKSGSGSSDESDSDDDQPAKAKGVSGLIEVENPNRVVKKNKKLNNLDNLGDGEKPQLSRREREEIERQRAAAAYQKAHAEGKTDQARADLARLAIIRQQREEAAKRREAEKKAKDEATKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRN1</accession>
    <name>A0A194QRN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein yellow</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRN1"/>
    <dbReference type="InParanoid" id="A0A194QRN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF13">
        <property type="entry name" value="DOPAMINECHROME TAUTOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="953" mass="108749" checksum="4593C0A9264F4F18" modified="2016-10-05" version="1">MAVSHQWFLQWSSPSVVFADISRQYENVQSNWNNHHHYGRVAYNPLDAQAAIRNSYREKQIQQQRVANNIIKYDRHRSLNVTVAIILPESDKHLIGAQCLVCVRNYLLQSIQTMYRSRPAALTLWLAMLGLARPQSVPADTDTPPFSTLYKWKTIDFEFPSVQHRRSALISRAYIPSNVLPLGLEVWGSRVWVTLPSWRRGVPATLATVSRGGGVTSPALKPYPDWNYHRAFSDDVNCFGLTSVFRVSADQCGKLWVLDSGQIDSQDSPKQICPPSVVVFNMQTDSMIAKYPIPEEYVLQDSLFSNIIVDSRQEDCSDLHLYIADTWRFGLLVFRHSDQKFWRFSHHLFYPDPLASNYTLHGLNFQWADGIFGLSLSPINNVEERTMYFHSMSSYREFSVTTDVLRQPARVNDSANAFKIVGESRGLFGQSSASAIDRNGVMFYGLVSRDSIGCWDSQKPYNKKTMGVVAMNTETLVFPNDIKIDQEQQQSVWVISNRLPMFQDGSLSDDDYNYRIMYVDTTQAVQGTICDPQLQLPPYSPLMRLVCLILCIGLAAAYRDHTQNKALNTLYRWKQIDFAYPSEQDKQRAIANGRFNQTNVIPLGIERWRNRIFISTPAWKRGVPVTLSTLPTSAGDASPPLTPYPSWEWHNAGNCTGFTSVFRMSVDHCGVMWVLDSGQVEAFETPRQLCPPTLYAIDLDTDTVIGKYPIPQKFVLQNSLITNLVVDSRDAQCRDLHVYIADAWRFGLIVFRNADAAFWRFSHYTFYPEPLLSNYTLHGLNYQWSDGLFGMSLGKVHLGDRPLYYHAMSSSLEFVVSTSVLRDPSRVNNAVDEFKLLGESRGPGGQVSAAAIDRNGVMFFNLISQDSIGCWNTYTEFGSRNWDIVATNFDTLVFPNDLRIDHEVPQFAWIISNRLPMYQFNLIDPNEYNYRVLYLDPVEAVENTVCQPRLYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRY4</accession>
    <name>A0A194QRY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRY4"/>
    <dbReference type="InParanoid" id="A0A194QRY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="26651" checksum="9F8B9650CE74699E" modified="2016-10-05" version="1">MDTDTPKTTLTHFEEWDDTLWVLKLNDVGLNLTILRSANESEEEYFDDEIGPLIHRHPLAYLSYKRRQNTKRVKKDDPKKSYPADHAFKDEPTNTHDTKYDGINNEVKYRVIQMINKFVLSFQKQPDSNLPETMDAYITPSLNLSISMTTDCCQARPFTALTVNYQRMVWQFFIQPPSPLPEWFYNEHSNINLGKNGMYVTIPDAIKEEFYEKLLHLLEKLFNYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTD5</accession>
    <name>A0A194QTD5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Suppressor of cytokine signaling 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTD5"/>
    <dbReference type="STRING" id="76193.A0A194QTD5"/>
    <dbReference type="InParanoid" id="A0A194QTD5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09923">
        <property type="entry name" value="SH2_SOCS_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF16">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="30081" checksum="852FA44E5E85EBC8" modified="2016-10-05" version="1">MTLTARLSPQNACVEVGVPLNSWSSGVACCPNCRHELRVSLTPCSGKTHNQPQTPVTPPFTIHPPYLPQSPLYTTPASPFIPSPYNDELRRLADTLRALRLSGWYYGNLDWQGARSLLKDASVGAFVIRDSGDRNFIFSLSVQTERGPTSVRLHFEEGFFRLDCDRPLARYMPRFRCVVELVQHYARVGERGAAGTVWVDREGCTHSPVLLKTPLRKNPPSLLHTARLAVHKALSNPLRPKIWCAPKHRLLPLPSTLIDYLGEYPYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTM9</accession>
    <name>A0A194QTM9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTM9"/>
    <dbReference type="InParanoid" id="A0A194QTM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="10586" checksum="416AC15D43434B13" modified="2016-10-05" version="1">MHRIIECTISGLGMLRRWVRLCSSAGPPRTPLSRFRVDDRTMQPWRTARLLALFSVEIDKFRFYDGYIALSMLYNFNKELLEWRTWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU83</accession>
    <name>A0A194QU83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Laminin subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_15224</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09083.1"/>
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            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ09083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="3701" mass="407844" checksum="7E6531E8685B2165" modified="2016-10-05" version="1">MERSVALLLLYISVARAEILTPPYFNLAFGKKITATATCGDEGSELYCKLAGANADHDEHVIQGQVCDICDANNEAKKHPPEYAVDSMETWWQSPPLSRGMKYNEVNLTIDLGQEFHVAYVFVQMGNSPRPGLWVLEKSTDYGKTFKPWQYFSDSPQDCERFFGKESLQPITRDDSVICSTEYSKIVPLEGGEIPISLLNYRPSSNKYFDSPVLQEWTRATNVRLRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADNCDPADPQSNTNILVCRCQHNTCGPQCAACCPGFEQKKWRISQNWNRFACEPCNCHNHTTECVYDPEIDEKRLSLDIHGNYEGGGVCKNCQHNTEGINCNKCQPTYFRPYGKKWDEIDVCQPCNCDLHYSTGNCEEETGRCECRREFNPPNCDSCAYGYFDYPNCKPCTCNLNGTEGDNCTPTDGLCPCKYNYAGKSCEICQDGFYSPECKNCECNSVGSVSHVCDKETGNCTCKSKYSGRTCNQCEAGYFNYPTCKHCNCDTSGTEASICDDVSGQCICKDGFGGARCDQCLSGYYMEVKGRERLCVPCNCSPTGSTSTSCSADGKCNCLSNFGGKQCDQCSPGYYKYPECLPCNCDVSGSIGSTCDDNGLCHCKPNFDGAKCDKCKEQFYNYPACEECNCDPRGVIASFAGCGSVPAGELCQCKDRVQGRICNDCKALFWNLQEYNPLGCEECSCYLAGTLGGLGACDTRSGQCTCKMNVDGSQCDQCQSGFYNLQNNNLFGCTECDCDIGGSIDNNCDKSTGQCRCHSRVDGRRCDRPIRAHYFPTLHQFQYEVEEGLTQSGPVRYRDSEEVFPGYSWKGYVVFSVLQNEVINVVHIGKSSLYRMVLKYANPLRDLVTTSIIITPESVVDTQQMFNVYLRPTEQPQLVTVTLEKGNAPAPFVMNAGNWTVTIKTTREVMIDYFVLIPEAYYEATVLTKLVDKPCAIGERNLCRHFAYPSLNGFPTANITTLITPVTEYVNNPEKQGEIGLSILIIINENLLQQQREYNLGPADIPLLISDQSELQYDMNIEPSGPYILVIEYVTPVNNTGSGAQIDVTISNVTDDYSPKGIITIRFQSGDGPEMGAIVNLNDCPYTTPCRQVVADDLSKIITVNVMDPNNVVYLEGDTDTLVGIKSIVAIPEAIWHLDYITPRPFCLRRNGKCSPGVFAAAVDSKKVEMEAGTGGGHYTRPTILDNSTSVVYLDPTSEPIKLESKVPTPGDYVFVVHYFQPNNPESNAEITVTIDNQKYEASLPIEHCPSNSGCRALITLANGNTQFSVNENFTLNFKGNTSKGVWLDYVLVIEKPDYMDTAIKEANTLDYTREFIENCAMNHYYINPNETGFCRDAMFSITAEYNSGALSCLCDFMGSTELECNTFGGQCPCKPNVIGRTCSACKTGFYGFPNCKPCNCPLTAICDDNGQCICPKNVEGDNCDRCRPFTFNFDVQRGCDDCNCNPLGVVGNQLQCEADSGNCDCKDNVIGRTCDHCVPGHYAFPDCLECTCNLYGTTEDVCDQNTAQCYCKKHVRGQACDTCKDEYFNLQPDNPDGCTKCYCFGKTTRCTSSYLTWAEISGMSDWYLVNVEVNRTLNIFPYTIAPTILNETVIGAELVSSDDEDQKLVYFGAPEYYLGQRLTSYGGYLTYNVFYTTRDDGFAVIEADVIIGGANGYIVHNSVEQPPSVVNWRHSVRISEDEFTNLDGSAVTRDQFMNILVNVTSIYIRATYWHQPVTTRLMGVSLDVAVEDFADGRQASSVEDCQCPKAYRGLSCEQCAEGYYRLSSGPHAGFCVPCQCNGHSNECDVNTGICLECTDYTMGDHCEQCIPGYHGDATVGTPHDCLICACPMPYPSNNFAIGCELSGNGSLISCDCKPGYAGARCEYCAAGYYGIPENIGDYCKPCNCSGNINPEDPSSCDSITGDCLKCVNNTAGAACNLCAPGFFGDAIFSKNCTACVCDEFGMERCDPTTGTCVCRPGVIGDKCDRCAPDHWGLNSGQGCTPCSCALASESSQCDDNTGQCRCAKGVTGKQCDQCAAGYWNYTKYGCDHCNCNTGYSLGFMCNATGQCECLPGVIGEKCDRCPERWVLIPHEGCLECDSCTDALIFSVEDLSYMLSNESVEFKDKADSFFTTQRLNYISNQTEQLKPRVTELRNVDLGEVTTAVKALETSSKNLLRSAEFAATDSENQIGRAATLAADADKILASVRDNGQRAKDIVTHVSDLATGLELSQQPKVDSALTEAQQIKSDILAKDLKPKEELAISAINNVDNQIERMNIFVQPVIEQTKRFQILVNKTKDLKGKLDEMLQYTNIAQKTADEAELLNDKNRESKFGNKVLSVTKLNSAAMKDLIDAALDINNATFFNALSGGIVNISSKRLEDLNNGNNEIEEMLELLKNDFPNLTNLTDVALHHAEGLRNRADSLRALAERENNNTRTQHAYSAASAYSSIVQEISDAKKAGDEAESSILNATKINNILQESVTPAKNKSMTLSETALSAQQTVEQKLRPNLTRAGEALKDAWKILGDADDENNAIQLSLPTSTSTSLEAETQKASKVMETVNFTSNIMSQLGKDLASSKEWAQSLPKVADDAQKMTSNIENLVNNIKDMDPKISSQYRVVKMKQESLEQRRKEADERLKKLRELVEQARTVANRVQFGVTFDRWSTLQPRLPDTVDEMSTSTHVSTYFRTKEKNGFILYLGNPKDTMLRRTKSDDFMVIGIQNGYPYVVMDIGDSAGKDPTKIGSDKFVADNKWYQVIVDRVGRNVKLSIRESLGNGTEYIHSKDATLPGQHTIFNLDRQKSKLYVGGVPSDAQLQGVSFPAFEGQIEELMIGDTPVGLWNFISADNLKGARQRDKLITSQSGPQEYRFNGRSHVTMPGRGYLVPQKNHVLLFFRTYAPDGLIYLVGEGSHFFSLQMQDGRIYLQVSLGNPDDLTIIGTTKAYNDGKWHRLDAGRYLTTCSLKVDGEVLKTVSTSETKEIPDLDTMNFGGNNKGIIQVTSKGFDGCIRQISIDGVNIDLSENIESVGIAYGCQFASLVSLSGDSSYLRYVNLTTENLQLTLKFKTSKADGLIFVYLSRTQTTTMSDSISLSLIGGKLVLMSQREQLDTGLGTYNDSQWHVVTVTHNDQALRLVVDDFDYFSTDTAPAPLHILDGVLFVGGVQPGYVVGGKVGSKAPFQGCIADATINGRMLNLLEPFSNNSVIFGRCGTTTTTGGVPPDRLIWAAPAPVDVLPTPTSLPPLATPAPDVVTVKVNPEENEIVTMTPTAPPTTTRAPFKMTTTTVRPSTTTRRPPPQPEAGCALAYDTHYGFGDPSEGYRFGTRNDSRIEYSKLPGRQREGFDFTITFRTFDQHGGLIFYAEADKAPGQFLALYMKDAKLHFTFNCGGETAFVQSTQTYNGTEWHTVTLVRKEGHGKLTVDSERIGEASVTCISPAILTPPFYYGGLGNLSSGIRQNLMDFYQPFKGCLKGLMMNGQYVTDIMYRVNSLRCTDNIEPGVYFGPSNNVHSNYLKLLENFKVGFEISISMEVKPRNSTGLLLSVHGKRDFMILELLENEVIANVENGKGPFHASYKLGNKFTLCDGNWHKIHAVKSRHVVSVGVDGHFSDAGLGQSGSTDTRSALYIGGHERPISKVRGVRSRRGFTGCIRNIVIRETPVQIPLTAAGRNTHVGVCPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW25</accession>
    <name>A0A194QW25_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_13372</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW25"/>
    <dbReference type="FunCoup" id="A0A194QW25">
        <property type="interactions" value="1716"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW25"/>
    <dbReference type="KEGG" id="pmac:106716596"/>
    <dbReference type="InParanoid" id="A0A194QW25"/>
    <dbReference type="OMA" id="AYHYGSE"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14119">
        <property type="entry name" value="STKc_LKB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000235">
        <property type="entry name" value="serine/threonine-protein kinase STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039154">
        <property type="entry name" value="LKB1_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="94"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="446" mass="50771" checksum="63AA2C9BE64D3B3D" modified="2016-10-05" version="1">MDPRMCRQISSSESLPDAENVEVEESNIIMPQESDDNFLLDGSPEPHSVTWLDDDQIDDLDINLDQNNLFFHRVDSADIIYRNKKKKCKMVGKYVMGDVLGEGSYGKVKEMLDSESLCRRAVKILKKRKLRRIPNGEQNVQKEIQLLRILRHKNVIELVDVMYNDEKQKMYLVMEFCVGVLQDMLESSPGKKFPQRQAHDYFTQLLDGLEYLHGQGVVHKDIKPGNLLLTLNQTLKITDFGVAEALDMFSPEDTCYTGQGSPAFQPPEIANGAETFSGTKVDIWSSGVTLYNMTTGRYPFEGDNVFRLLEAIGRAEPAPPPRCLGPALHSLLTHMLSRDPDLRPDVHQIRRHAWIQATPALEAGERLVNPRSRRSDEHHNSTVIPYLVERHYASAQEYFTERDLRHELGDNGSRTMSTAELSDGESTQCKRRWHSSCGRLPSCRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW64</accession>
    <name>A0A194QW64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW64"/>
    <dbReference type="FunCoup" id="A0A194QW64">
        <property type="interactions" value="1193"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW64"/>
    <dbReference type="InParanoid" id="A0A194QW64"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="30398" checksum="4E76A07262C449DC" modified="2016-10-05" version="1">MACNPRNPRPATIFNNAHGQISVYGDDVEVDYRGYEVTVENFIRLLTGRVHHDTPRSKRLLTDEGSNILIYLTGHGGDGFLKFQDSEEVTSQEVADALEQMYQKKRYNEIFFIIDTCQASSMYEKFYSPNILATASSLVGEDSLSHHVDYLIGVYIIDRYTYFVLEFLENVHPDSKNTMSEFLAVCPRSACLSTVGVRKDLFNRDPSKVPITDFFGSVRPVVITRKPIEILDIPKRKKQVPVENKTQIVEKMSYLPQFPMHLVQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXB9</accession>
    <name>A0A194QXB9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXB9"/>
    <dbReference type="FunCoup" id="A0A194QXB9">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXB9"/>
    <dbReference type="InParanoid" id="A0A194QXB9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07595">
        <property type="entry name" value="BAR_RhoGAP_Rich-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="252"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="807"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="98228" checksum="05DB0171A041435F" modified="2016-10-05" version="1">MKKQFYRVKQLADQTFSRSGKGEALTDELQTADRKVEHLRNALHLISKRLATCAGNTQGQDPAAREKRLKKLPEYLLGLSMCEASNFDDDDSIMKYILYECGKTEKFLANEIAEHELKVEQLVCAPLAAISDQDLPAIMKAKKQLSRLISEKESATSKYHNLERQKEENPAKLNAAREELEEAGTRVEAARDALAADMFALVAKEAQLAHTLLQYVKLQRAYHESALHSLQDTVPELERFINDSSVKPVFGYPLEEHLRVTGRTIAFPLELCVCALHELALNEEGLFRIAGGLSKVRRMKLSLDAGLFSVPLPRDYRDMHVVASVLKSYLRELPEPLLTYRLYETFISASRQPAEQARLNAVWDAIHLLPPHNYQNLRYLIKFLSALTQNQSTNKMTPSNLAIVIAPNLLWAANESTLDMYITSAVNCVVELLIKHADWFFQDEINFFVTFTKEDLLPDQCEYGFSPNFVHGYNQTAALGQDQSNGDYSSMSKSMFDYNHQPSHHKEPDGPGRHSRSNSHDTSLILLDNDIKKAQSNSSLSDQSSPPHGSPKPTMRRKNKAPVPPNFTPDKSKQKAEAQTQVVDATKEQHPAKVDNEKPAKPPRPVISETGKVITGVQTINRSTYRQSKAFKDEAAKSGSRENLTDVRRQSLELEKDKLDSLKPIENRDKESTLVVKNVTATTGVVGRMKVIGDASSGPASLGAECKGGPTRIQITAKPTGQPPPRPVAAPRTILPTGAGAGEAEVGDNGGGGRRGGAVPERPATLRPQSFRARTSADNADIAPTVLERTHIYTVDKQHPTVIQVGGAHVDPAPEEPARNTVQRTHSSGGKDAELEEPKSLGASRQLSQSEGSITETPLSPRARPPRPMVPAPPPPVAPPLSPPHHESTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ20</accession>
    <name>A0A194QZ20_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Histone acetyltransferase</fullName>
            <ecNumber evidence="20">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_07901</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54020"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13758"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:138019"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54021"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM (via its Tudor-knot domain); possibly regulating the activity of ATM. Interacts with NELFD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="20"/>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ20"/>
    <dbReference type="FunCoup" id="A0A194QZ20">
        <property type="interactions" value="1389"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ20"/>
    <dbReference type="InParanoid" id="A0A194QZ20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005705">
        <property type="term" value="C:polytene chromosome interband"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061920">
        <property type="term" value="F:protein propionyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000039">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="22">
        <location>
            <begin position="157"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="442" mass="51589" checksum="F52DEE9374D3A8F0" modified="2016-10-05" version="1">MAKGDKEFEKPIVKDELPNPECRNTDNEESESVQEQQPLDIGEHYLVRRSDESWHPAEIIQTRYNAGESCFEYYVHYVGYDRRLDEWVSRHRVMSDRFDVCEQSNNINSDHLLTDKSGRKITRNQKRKHDEINHVQKTYEEMDPTTAALEKEHEAITKVKYIDRIQIGKYEIDTWYFSPYPDEYGKQSKLWICEFCLTYMKMEKTFRYHLGQCPAKQPQGSEIYRKGTIAIFEADGKEHKTYCQNLCLLAKLFLDHKTLYFDIEQFLFYILCEVDKYGAHLVGYFSKEKDSPEGNNVACILTLPPYQRQGYGKFLIAFSYELSRLEQVVGSPEKPLSDLGKLSYRSYWSYVLLEVLSVSRGTLSIKDLSQMTGISQTDIITTLQCMNMVKYWKGQHVICVTPKIVAEQLASPHFKKPRLCVDRSALRWSPPNKQGNSAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0U0</accession>
    <name>A0A194R0U0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0U0"/>
    <dbReference type="FunCoup" id="A0A194R0U0">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0U0"/>
    <dbReference type="InParanoid" id="A0A194R0U0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="9">
        <location>
            <begin position="399"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="638" mass="70379" checksum="BE2FE51E516A60CB" modified="2016-10-05" version="1">MHWYGGSIAEAVALSKQRNAIFVVFVEGDNEQSAEMSSTIDNVAVEKRLSDPENFLAIKLKSGSINYTHFAQIYQFVPVPSLFFINRNGTPLEVVCAGVEAQNLATRIDRIIEEHNQFVPVPSLFFINRNGTPLEVVCAGVEAQNLATRIDRIIEEHNKDKKGTVQPSTSGQNLKQQTANLIQAEAGNPGNESVPATPPTCTTSNEAKTATPSTSRSSIDVEPETSSGPAAKVPKTEFHEVTRSGQEYEVVCDGDVCVRKPKEKLEEPGPSTKDTPANKPAMSAASSDEKVERAKELIEAVKKEKLEKEKELEKQKELERRAVGQGVTELKKWQAEQELKQLQEERKREKMENNLARQRILEQIAQDRAERRARDMPPPQTPQPPQTSQPSPPPSTVGDGGSRARVQFKMADGNAHTAHFDVDTTLLELRRYVSTNLHLRQSEFSLWTAFPRQELTEEGSTLRQLRLAPSAALLVLPRRVPDTVATPTTFSNIIWRTFGRPFKKMAAALIPLVFQMGAAATWAVVAALVGIKTLGVTLIILKLLLIAGAVKIGALFGQKGHHSSGWEPPPHTPQKEIHLHIHNGQHGHSGPDEHIPFSSWSRDGTQSSSDTKPMNVVYEPYVAGPQTISTPYGNYVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0X9</accession>
    <name>A0A194R0X9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chorion class A protein Ld2/Ld41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chorion protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0X9"/>
    <dbReference type="KEGG" id="pmac:106715159"/>
    <dbReference type="InParanoid" id="A0A194R0X9"/>
    <dbReference type="OrthoDB" id="6930117at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264812" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="14478" checksum="F2DD3406EB9EFD58" modified="2016-10-05" version="1">MSPFAFLLLCIQACLIQNVYSECLGAGLGLGYAGGLAGECGLGYGPGLATEFGYGPGLGLGYGAGLGLGYGLAGPAAIAGPAAIAGPAYGGTGIGDIAVAGEMGVAGTTVVAGQVPILGAVRFGGDVPAGGVVSIAGNCAGGCGCNGAYNGAYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R129</accession>
    <name>A0A194R129_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette sub-family G member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R129"/>
    <dbReference type="FunCoup" id="A0A194R129">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R129"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF61">
        <property type="entry name" value="SD03967P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="554" mass="61458" checksum="C6F42986B4DE8F21" modified="2016-10-05" version="1">MGPSGAGKTTLLNILAGYSTKGAKGEIKVNGAPTCASHSTSRGGARYIRQHDDLRVHLTVYESMALAAALKLADFTAHERKEKVYEILALLGLSGAARTLCRDLSGGQKRRLAVSLELISDPSLLFLDEPTTGLDSSASASLITLLNGLARGGRTLIATIHQPSALLFEKIDSVYCLANGRTLYSGPRQHLLPALSSAGLRCPAYHNPADFLMEVASGEYEVDLVKVAKTVTYYKPEPIAEASLEESAHMSLNKELKQKPLQSNAKYQRSYSKNIYRPSGNFRQTWILLYRNYLMTTRNYSLFMYRVAAHVVIALIFGYLYFGVGSEASSVLGNYVYLYGSMLLVVYTGKMSVTLSFPLEMDILKGEYFNRWYNLGPYIFSILAVELPFQMISCVSYVVLSYWLTDNPLEPTRATLFLATIVATSLCAQAWGYFIGSTTPTKIAVFIGPVLACLFSVFGFCLALSDTPYPFRWLHHISYFRAGFHVAVHSVYGFNRTKIHCAKEYCHYITPSKFLVEMDMAHVDVGGNMALVLSTTVLMHLLTCGALWYRLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1K1</accession>
    <name>A0A194R1K1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuole membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1K1"/>
    <dbReference type="FunCoup" id="A0A194R1K1">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1K1"/>
    <dbReference type="InParanoid" id="A0A194R1K1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="495" mass="54669" checksum="D7FCE9FFD359B3B3" modified="2016-10-05" version="1">MTKAASTRRVRNQASSLTVPRQNSLPDNGRAKQNTTCEMLAAMNKEQLRAECRKRGQRSSGNKNELLARLGYYKLAAAVQQNDTDQRPRNGLHNHPKDIKNKAIQMDTDSLVLWRRPVTTLEYFFRELLILISTGLQRLLAYKLLALVIVLSIAATVTSYYVGGLTNHMFRLLAYKLLALVIVLSIAATVTSYYVGGPHQPYVQLVVAKMAWWGWWVVLGVCSSVGLGTGLHTFLLYLGPHIARVTLAAYECGSLDFPEPPYPNDIICPGEIAGEVSVWSIMSKVRIESMLWGVGTALGELPPYFMARAARLSGGSLAEVTDIADDNTRSGRAKVMVQKLVQRVGFAGILACASIPNPLFDLAGLTCGHFLVPFWTFFGATVLGKAVIKMHIQKMFVIIAFNEALVGQALGWVSKIPYLGPKLEAPLLEFLRNQKSKLHKRDPSAPLPENQGSLVSSLLEKLVLTMVLYFVVSIVNALAQNYSKRIGKRKGKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1R0</accession>
    <name>A0A194R1R0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Disks large 1 tumor suppressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1R0"/>
    <dbReference type="FunCoup" id="A0A194R1R0">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1R0"/>
    <dbReference type="InParanoid" id="A0A194R1R0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11861">
        <property type="entry name" value="SH3_DLG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000004">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="297"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="377"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="557"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="744" mass="82264" checksum="FB4A2FBD47EA6C4B" modified="2016-10-05" version="1">MTERRKKKTHNGFLRKVSSLFNLDTVSEPPVLAHVPTPEMKQINGIEGGGTDRTVGEDGFLYMTVALSRAGGAGLGFSIAGGSDNPHVAEDPLIYVTKLIPGGAAAASQLQINDAILQVNDTNVENVTHAEAVDALKKAGNTVRLKIRRRTAEDTLTVPSITNKEQAVEIELVKGGSGLGFSIAGGVGNQHIPGDNGIYVTKIMAGGAAHRDGRLRVGDKLLMVKNTSKGDVNLDNVTHEEAVSALKASGERVQLVLVPGPRHGQPSPRTSRANTPSSTANSLRREDVTDSSEEPRVVELEKGPQGLGFNIVGGEDGHGIYVSFLLAGGPAEKSGELRRGDRLLAVNDIDITHATHEQAAKALKGTGQNVKLTVVYRPQEYNKALFDYDPVRDDGLPSRGLPFRYGDILHVTNASDDEWWQARRLDTTEADAIGIIPSKRRWERKQRARDRQVKFQGQGTPVSTSQSTLERKKKTLSFSRKFPFMKSREDGKSEDGSDQEPFMLCYTQEDTNADGEILYRVELPMMEEITLIYLEDESQDENVLSYETVQQLTISYTRPVIILGPLKDRINDDLISEFPDKFGSCLKILHRDYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSVESIMEMNKRMTEDQAKKTYERALKMEQEFAEYFTAVVTGDTPEEIYAKVKAVITAESGPTVWVPRREPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1S0</accession>
    <name>A0A194R1S0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1S0"/>
    <dbReference type="FunCoup" id="A0A194R1S0">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1S0"/>
    <dbReference type="KEGG" id="pmac:106714849"/>
    <dbReference type="InParanoid" id="A0A194R1S0"/>
    <dbReference type="OMA" id="HWAVRDK"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000049">
        <property type="entry name" value="DnaJ homolog subfamily C member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="19129" checksum="400AFFFF65FD3276" modified="2016-10-05" version="1">MTGVDEILNYQRNPDDDYYALLGCDENSSVEQITAEYKVLALQHHPDKNDGDKDAEAKFQQLKEAKETLCDPSKRALYDKWRQSGVAMGYKQWLSMKDHVQQSMHWSKPNTKDRMLEGELGHSSGPSSLGPTNAAARRASEGGAALWGRWGPGNQEPPSEVISKFRNYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R228</accession>
    <name>A0A194R228_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein Gfi-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R228"/>
    <dbReference type="STRING" id="76193.A0A194R228"/>
    <dbReference type="KEGG" id="pmac:106714175"/>
    <dbReference type="InParanoid" id="A0A194R228"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF138">
        <property type="entry name" value="IP01201P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15418" checksum="44465B9A7C6F7683" modified="2016-10-05" version="1">MPNAYNKTGQMTHCNLCSPGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFACELCGRAFQRKVDLRRHRETQHADLRAPQHLPHTDVHGMHAQDMHAVEHRIDLRPPHPELRPPHPDFRSHLSSAVPPLQALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R340</accession>
    <name>A0A194R340_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R340"/>
    <dbReference type="STRING" id="76193.A0A194R340"/>
    <dbReference type="InParanoid" id="A0A194R340"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12534" checksum="7783DA527464C371" modified="2016-10-05" version="1">MTEEKLLHEEVHTNWEEAQRLGVSGDLADELRPFLPPGVDVTFIGSRPRTKEVLQRRMYQADIQKWLSEEDDSEDLPPSTTVTSSEDPLAPPLIQQPDGDNHQIRPGYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3G4</accession>
    <name>A0A194R3G4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat, SAM and U-box domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3G4"/>
    <dbReference type="STRING" id="76193.A0A194R3G4"/>
    <dbReference type="InParanoid" id="A0A194R3G4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="5">
        <location>
            <begin position="908"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="996" mass="104700" checksum="6CF8A9CCBD385DFB" modified="2016-10-05" version="1">MTAQVRSRSRDGIFMTCDIGGRPRQRHAVPAPSLDNRRKPPSVATSLVQFNFQKAPEDSNSFTQRTMHEESVDPHVVHSLRAHRGEVACADVSGALLATGGGEGALQLWRWRRGAGWLEAAGAPRAHRFGVTAARWASSGALLASAGVDGAAGIWTRELKRRRVLAAPGATAARALCWAGTRLLVGHDDGALCVWASRRGTLLVRLKPCEGALHALAALPPAGLLLVACTTGTLKFFDLGDVYARDEVGHDPPALLWEDGAHDLGALCAASSTCGRAAASGGHDARVRLWRAAAAVGERRVRAGGVLSGHAAAVTALAWVCGTRLLVSASLDSTARLWACTTLTCLRVLHAHTRYLTCIAVSPDFRYLLTGSNDRTVRTWSMGAFGLDDDVTPSCSLLSHFGLGDLKGIEPMFEDELVEGSGAGEGAGEGAGEGAGEGAGEDAGEGAGEGAGCGAEGAPPERLWVSEETHVGAINSIVIIKDVLVTACSDGGVRVYRWSARRGELVCERTLLAHRFPAAAVDLADLGAAGTLVLSAGLDGRALLWDLQSGSELLSVSAGGAGGATGAAGAGGGVRGARLSPHRPPLLLLGMDDGALAVWTVQQSNTEPIHVYEPFAEAATCCAWSGEGRICAAGGAGGELRVLGPPPAAATLHAQRDAHDLGVLSLDFAPLQNKDESKYIMASAGRDTLVKIWEIRFEMRYGAAHVNVRLVHRVEAHGGSVECARWAAAGGAQLATCGADGWARVWRLAPGGDVRLVAAVPTGGAGAAVGAMAAAMLGPTLLAVGSLTGELAVWRVPAPLADVDEDDEPEPRMWGPTGVARWLRDYVTRVPEDSVSEQGSGATSGEARLSGARLLQEPLPDLMPELLRLLRRLPSEEANLDNERLLKRLEEEIEWLRREAPAPELEACAPHTLRCPLTHALFREPVRAADGFTYERANILDYFFVNEAAVSPLTGRRLRSAHLSPNLVLRQQLRDFLCKSTAPDASGSDLSRPAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R400</accession>
    <name>A0A194R400_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_11505</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R400"/>
    <dbReference type="InParanoid" id="A0A194R400"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264907" description="Cytosolic beta-glucosidase" evidence="19">
        <location>
            <begin position="26"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="515" mass="60266" checksum="CF0B141BCE36C646" modified="2016-10-05" version="1">MRAVEMCSHTRLLLFVILNVVLVDSKYQNRRSTRKFPVVFRFGTATAAYQVEGGWNEDGKTESIWDYLTHTNPRAIRDGSNGDTAANSYYLYKRDVEMMRELGLDYYRFSLSWPRILPTAFPDKINEAGVEYYNNLIDEMLKYNIEPVVTIYHWDLPQKLQKMGGWSNPYIIDWYSDFARVCFKLFGHKVKKWITINEPAQICDFGYGRDLLAPMLQIPGVADYICARNLLLAHAKAYHIYDKEFRPKQNGAIFISLSAQFYSYEFDKYKEAALEANDFNWAIYSYPIFSKTGDFPPSMKKRVARKSAEQGFFRTRLPELNPEEIAFIKGTSDYFGLNHYFSYYVYRNDSVNGTFESPSTDDDLGVATYFGDRWQIGESNATMFVPKGFYYLLTKIRNDYNNPPVFVTENGFSTRGGLRDDDRVTYYRYYISAMLDAIAEGSDIRAYTAWSMMDNFEWTAGYTERFGLYEVDFSSPNRTRTPRKSAFIYKQIVRTRELDWYYEPESYVMTIDKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4G6</accession>
    <name>A0A194R4G6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein winged eye</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R4G6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052429">
        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048924">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056841">
        <property type="entry name" value="TNRC18_BAHCC1-like_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21744">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24912">
        <property type="entry name" value="SH3_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1330" mass="146480" checksum="E6D07DD4A0CBA3D5" modified="2016-10-05" version="1">MESMMVGGMGMGVSSVGSVGGGVGAVGGYQLVREPTSGALLLLPAPPDLPHTVVWGGVPYPPAPLLLPPAPHAPHHLQLLHAPGELLASTATLQHTHTHSTRLVTLAPAPAPQPHPAHSVDKRKPIMQPLITPHALIKIEPEPPQEKPPPTFAPEPVQQPILTHLYYQPEFSEQACRSQATSPAAPPTPPPDAAEGPAHKDASNQTDHVDDYEDSPNHADEDEREIACVGVAHFPEESSALQLQDHGHQLQPPPIDSAEESSSEALANSTVVGAVEKAIDAIERDDSMDNSSSGGSHDLVIDTSGSSPVPAVQPAGPLVDVSGLELLSNSIEQFERTTPGISMPTLDQTPLTIDTRPTTKLNIMIKTSPKSPPRTDAEPHRRFEFPAAEPIAGERTKPSLDGLDILCALAEQRFMEEVEESPPPVLQLPTRPFIKTEPLLSPPPLERSLELIKKDKHNRHRDDSSSERRRKRSRDREERLRHKLEKMRRHKREKDREGGKGSGGELEASLRRVTACPCGSMTCTHSSTVPSAKALVNAMEKDMRERLQELQRQCDEKRAQLNALTPPLPALSTPPTPSTPALSPNSDRGSSKKRKVGRPRKVSSPDSTETIVAKKPKSKSSLVGYLLAKGKLKGGILCSRGEPSRDENRTSKVRPKLKAEPILKVYSEEEEVDGSLNRSASSSMESLNEVRQKNREKVDRLVRKHSRDDLPEIELAIRRVSASSESDKERRRAKKRRKSLKSKERPSESSKEESAQAPAVSRCTLTEDKLDSSPRVLTAMGGLFYAGKLSAVQAPDVYAITLDGERGNKPHILSREETLRDAILEVSPRSVSELGSGTRVCAYWSQQYRCLYPGTVALASPDPRHDHLVPVEFDDGDSGRIALEDIRFLEPNYPIVEYENTLFTLGKRRRNTSVTEDKKAVVPSTSTEVKTEPGPPSQTVTEDKAEEEDRHRDRKKLKKHRKEKLKRLHSSEEDPNSTEYVKKKKKKHKCCEEHCKHRRHHKKHHRKHKKRHHSSCKEHSSSSGDDHHKRKSSTDYVDSIKSNEDSGDSNDRLSTLIAVEKSPDEKMKTVIKKAVLSKKTLVKNAILDFSNLGRITLKKDDDVKDNLKDSGIGLEVDVPSTSMDAPKKKTKKRTVSSTSTDSGAACGGGGGGGGGAGVSKMAAFLPGGALWRWLGPAYRRTARPRHRKLFYRAIQRGEETLHVGEAAVFLSTGRADRPYIGRIVALWEARGAMAVRVEWFYHPEETVGCRGPLKYPGGLFESPHTDENDVQTISHKCEVVPLAQYQARMAAEARAADDNNDLYYLAGRYEPTQRALSMQPDVPFADDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4K0</accession>
    <name>A0A194R4K0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4K0"/>
    <dbReference type="FunCoup" id="A0A194R4K0">
        <property type="interactions" value="1971"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4K0"/>
    <dbReference type="InParanoid" id="A0A194R4K0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="6">
        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="326" mass="37418" checksum="6C6226C4E03CC06B" modified="2016-10-05" version="1">MTDALNHLVVDGNEVLELKLVRTVKDIEDDEASFGPEMCHQVFGENENIFGYTDLNIKLYYSAGSLQTYLGIDYTNKIEPSKSDGMKADDVEGALRKVLAPGYVTNLDRFISLLGKDRNFVPHGQLEHAFPLESLLAPGYVTNLDRFISLLGKDRNFVPHGQLEHAFPLESRDGGDKRLFEVYYSETSTPGFLAYHQRLQTFLLWYVDAASFIDVDDDQWTFFTVFEKYWTSDGEVRYATAGYATVYRYYAYPRHTRPRVSQSVYSHFISQPEVVDITVEDPSPEFQRIRDYVDAKNCESLSAFQPAKLLQGYVIHYFSSFDEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5N6</accession>
    <name>A0A194R5N6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transport and Golgi organization protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5N6"/>
    <dbReference type="FunCoup" id="A0A194R5N6">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5N6"/>
    <dbReference type="InParanoid" id="A0A194R5N6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035459">
        <property type="term" value="P:vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051500">
        <property type="entry name" value="cTAGE_MIA/OTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158:SF33">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264942" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="669"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1267" mass="142050" checksum="5A54AEB0BF2CA5A8" modified="2016-10-05" version="1">MIVFQFYVFMLLVSLFQCRLPDKVICANEKCSVPISKAKTLLTYNSGDPDLISFRANSEALVYMKSAGSNPDLWYAKINGKTGFVSSRFLRETKIIERNPTFLVPIEKNVKENVQPDKVQLPHEVFEGTTIFTTEATSNQEESITEQPESVTTESSIPLLSAVETQNIDSENNDDSVQSETDSTISESVNTATATVVDNNPVTDNVASDILKIQENLISNNDNKIIENLIHPNVEVNSNSIENVLLNSNTQENNAQGVDESEKIITETIDNVTIEAEKNLESADISKEIPKTITSTQESEVPSFATPSNNANIEQVEQNNPNLSSETLNSISENFSSQEQDARSSENINLDTNTEIPVESTNIPDTLPSKEVSEGIVQNIIPSTNTENVENNSPKAEENNVPLDTQIESIQKPSEPEIPYNIDNKFNNLPQQDILNNLQNSQPFLSSNTIPAATIEAIHTETTTEVDNNATPPIIQTRDETTTETTNIPDIDEVISSSSTSSEDSDGTTMSDSNTSQTESLSQQITIEDLYAMSTESPEVNEDSTQSIISDMYSTVASLWPTTTETPPHYESLFNPENPQPEVEKEFSIMKYIVSTYNNVMGTNEQTKAIFASAGETCFTDEYCDGESFSQKHRLLTFLLTTAGAVLLFTLGYYYIENKRQDGKLIGTINSLQRDLLFSTKECEILKEELATTKNKLTGIEDNSFGMDDMVKSLKEEINELNAQNDRLRNSLDDNEKLLRVSENTAGELQNTLGEVENTLSELLAERDHAEEQIAELNGKIQAFEEELISVSRERDNFQLKFVSAETSLEEYKKQKKQFEEINKKLSEANNTIELQKHEIEALKDVIKELKSGTPSDVDAATLIDHTEIKAKLSKALEERQTYLSKYEIEHKERVRLAEELKTTQESYSTSSQQAAEALTRLEVLGKYFQERESELMKELNAKESLWLSKQGESASTVEKIELLQQELQRFKEKCDALTLELAEAESTRRTAVSEMEARVHAAWLEARAARRDADAARDDATALRRKLASLSTADGAASPHAQVSSPLDGVDSGVIPPPLPPLAFLPPLLPPLPRPPPLGRLPSPHPPRYNDRRYSPESRYSPESRYSPESRYSPGTVRYSPDTRYSPRSRRSPYSPRRRRSRDRYTEGRGSRARNGPADTETEYNSDSPTRQPRAPRQPRRRTRYSSRSGTMHLVLLKVVKEQLSVHLSHSIYTESYHLATLTFRHSLDDRTQRRSTTLTVPHDSRVHLDSLDDVPDTPADRVQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R616</accession>
    <name>A0A194R616_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inactive hydroxysteroid dehydrogenase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R616"/>
    <dbReference type="FunCoup" id="A0A194R616">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R616"/>
    <dbReference type="InParanoid" id="A0A194R616"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264939" evidence="6">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="365" mass="40956" checksum="0245D6CFEA23FF8D" modified="2016-10-05" version="1">MLETLVYMFLCTLTLLSLLELIRNCRSKSREDEVPKEKKEMWKAPLKLVKQTLSKTKMADSPSTPETKQNSSINILVTSHLMPFFLPTEVQSLTKKFGSWAAVTGSTDGVGREYARELARRGLNIVLISRNHDKLRNVAAEIEKESAVKTKIIVADFSKGAEVYRHIEEELKDIPLGILVNNVGCQYEYPTQLCELPAEKAWELINVNVGAVTMLSRLALAGMAARGRGALVNVSSGSELQPLPLMAVYAATKVYVRSLTLAIREEYASRGIYVQHLSPLFIATKMNAFSPRLSRGGLLVPDAHTYARHAVAALGRVHDTTGYWLHGIQYFFIKVAPEWLRIKIGMYMNQDFRNEHFESVRSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6T8</accession>
    <name>A0A194R6T8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal acetylcholine receptor subunit alpha-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6T8"/>
    <dbReference type="KEGG" id="pmac:106712467"/>
    <dbReference type="InParanoid" id="A0A194R6T8"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264958" evidence="6">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="424" mass="48123" checksum="9FDB9A7DCF001D5B" modified="2016-10-05" version="1">MLSLCIRLVFLLHFYSICCYADDTCPSERDQPLHDEAKLHKDLLCAYNVDNRPVTDHKKTVTVKLRVVLKYISFDSLEETFTLHSWMALTWKDEYLKWTPSNYGGIKEIQIESHEIWTPRLALFNADASLYQSDNIYTTCLLDNDGAVTCVPPVAHSGICRTSLRRWPYDTQNCTLFFGSWMHTGEQVNFTFYNNSPIVMDDYQNGPGWRLTNVLNERMPGKYSCCPNSTYPMLKYTFMLKREAAGPAAIVVVPSIAIVILTLTSLVLDIRDNTRLFMICFSLFGHFIFLTEIGYDIPKHSADTPIILLFVRDSMIVTLAGVVVTLVLMSVRRRVVPPPAWLAAANRLVTSGPGKYVVFTEFDPCDTTEVKTLSDDGNGSNLNEEKSRTATEWILFANLLNSVVFIVALIVYLVLIISYIPRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7R1</accession>
    <name>A0A194R7R1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7R1"/>
    <dbReference type="InParanoid" id="A0A194R7R1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="25741" checksum="8CF8FA1F2C8BF7CC" modified="2016-10-05" version="1">MPTTKEVRTGSLLFPEKIIGGVIEMVHSHKSKPTTQAPYTQPPAYPQQYPQQYPQYQQWNGQANGQGNYQNPGYSQYQSQYQGQTQNYAPQNGYQGYQNGGSYSSPSSQTYPVNQGFSNSQGQNQNHYQSNYQQPTGNYQQTQHFQSQQGTGQYQGQSGYYGQNGGQSTQISQTPSVGQSGFGGQGFQASGGSQVSGSSPGPTCVCQAWTKPQHDELKDGLEPQKMEKNQQSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8B2</accession>
    <name>A0A194R8B2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basic juvenile hormone-suppressible protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8B2"/>
    <dbReference type="FunCoup" id="A0A194R8B2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8B2"/>
    <dbReference type="KEGG" id="pmac:106712117"/>
    <dbReference type="InParanoid" id="A0A194R8B2"/>
    <dbReference type="OrthoDB" id="6371642at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264985" evidence="3">
        <location>
            <begin position="18"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="158"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="749" mass="88744" checksum="36CBD7F8CF8A46AD" modified="2016-10-05" version="1">MKSIALLVLGLAAMASAHIDLDVHLSVTMDIKQKQMFILKLLNHVIEPVMYEDIKEIGMNFKIEENVNLYTRTDVVKNFVNWVKMGMLPRGEIFTIHVDRQLKEVVSMFHLLYYAKDFNTFIKTACWMRLYMNEGMFVYALTVAVRHREDCKGIILPPPYEIYPYYFVRADVIQKAYLLKMKRGLLDAKLCDFYGITKTDKGVYVIDENIFDKRVYLSDEDTLRYFTEDIDLNTYYYYFHVDYPFWMKDNVIDKLKMRRWELNLYVWQQILARYYLERLSNGLGEITTLTWNKPIRKGYWPWMLLHNGVQLPLRPNNYVLVGDKDINVVRLVENYEMIIKDAIIKGYIDINGIRLDLVKYEDVETLGKIVFGKIDKVEVDKFHIDAYRYLLIIMKSVMGLNTFNSDKYFVTPTVLDIYQTALRDPIFYQLQKRVCDLLILFKKRLPCYTKEELFFPGVKIDNIVVDKLVTYFDDYLMDMTNAVTLTGDELKKTTSDMVFLVRKRRLNHQPFTITLDIQSDKTVDCVVRLFLGPKEDHWGRLIDLDQNRVNFVELDSFLYKLNTGKNTIVRNSMDMHNLVRDRIMTRDLWKKIDTMTDMRDLLMKDLRNYHTGFPTRLLLPKGRIGGMNFLLYAIVTPLKLVDNVDINILDTNRRDLVVDFRSTVLLDKMPLGFPFDRTIDVAKFFTPNMKFVNVVIFHKKQVCDMKTRWDRWVLKNYNMIDRTIVGVDDYMTDVDINKKVDKDVNLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R996</accession>
    <name>A0A194R996_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-dependent dopamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R996"/>
    <dbReference type="FunCoup" id="A0A194R996">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R996"/>
    <dbReference type="InParanoid" id="A0A194R996"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF323">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER BEDRAGGLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110950" checksum="015D81C2DE97E321" modified="2016-10-05" version="1">MEAVDMDAGRYELRESLPGSSVDSDASSSLLGSNDVSEHSDKTSDDEEDLREDLQKTIPECYKSDSNFALHSTKNITNDEEFQATALCQFMDILNDLDEVLDKSLLACLDDTQNFDSDEEDIICKLKDCIADHEQQLDDSPSESSMDNTQVVIRQSTQSLEPASEDIELVQNLFEQPQCTSLRRSKSYSELPQNHRDTQQLERANTMNDNLRNSMRRLDPIVLPALNTESVCEPLTLPVILFLEHHVNMRPTSAPLQLQVTAANLSTSSGSSGPIIVGRRALLMNRALSLPSPGDSDITSAGWNGPNGRSIARSTSSTSSSSGESLAGIAAMNQNGAGTSDERNEETDEPPFGVWPHRMSSMLACLSCTIGIFNISRFSVFSVHYGACFILQFFILSLFTGIPLFTLHLCLGHVLQSGPIDMWRISPIFKGVGVSLLLTQAVIGMYSIISLSWIFVYFRDSFITSDDKYKWALPLGFSFDDVNLKNSTFKIQETIPQYFHGEVLQRGTGSNNHFGTIKYQVALYLAVVWMIVFVALSKGLRSYGKSWAAAAQETFLTWGLLGACVMQLTSHRSRGRGHSTALRQSGCVIACTFSVLLLAACLANTCVRILKNNGYVFLPSSFETVKSSEFLWATSEPLPGSVSTPVRYMGQYGSLVGVSVWRSGNTAKLYSGWQPLQLATQIVPATLAVVPASVLSPAWAVIFFFILLMFGVAQQLAIWHCVITGVMAINKDALRVWETTITFFSCVFGFAMGLLLSTDAGIRVVHLMDYVWVGSWWQCAVQVALSAGVFAVRGRPYSADAVAAALYRPATPLAAPLAALLAFTWSVLLPVLLCAICIMDFRIGQQRQLYSWRKPIGYFPIWARQVAVMMQQGALLTVPIVAFIQTWRYMNKGPPDILERIQNLYRPRMGGASESPPPSAAAPPPRAPPDPPPKYTPPPSYSTATGARLINTLRRSFRTLRRITSGRTDAPTDDAAQIPITVSESVDRRPPTPKLHTHPHPFHHSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9E4</accession>
    <name>A0A194R9E4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metaxin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9E4"/>
    <dbReference type="FunCoup" id="A0A194R9E4">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9E4"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrion organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03212">
        <property type="entry name" value="GST_C_Metaxin1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="407" mass="46639" checksum="352F9FEBFC43FA93" modified="2016-10-05" version="1">MSNIQLDIWRGEWGLASIDLECLKVLTYMKFIGVPVKVHEANNPYFAPKGRLPVMRDGRHVLTTFEEVVDHLKSLHYSTDVHLNTNQAAEASAFTQYLREKLYPAYEYAWWVDEKNYTELTRPAYAKALRIPFNFYYPGKYQNVAKEMIDALYGEHSDLKEIEKTIYQEAEKCLATLSDRLGESEYFFGNRPSSFDAIVFAYLAPLVKAPFPNSTLSNHVKSIPNLTRFVARINQKNFRQVTDEYNLQNSKKQSTGTQADRAAANFPNQYNTIRSQYVTQVTMCRLFLLVIPTHKPHASTPTSKPELKTVAVADIGRDYIIIIISKKKVAVPWKYNLQNSKKQSTGTQADRAAANFPNQTRNKILAAIFAAFAMTGYAFASGMFQELKDFEHSRDYSEMFENEEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAE7</accession>
    <name>A0A194RAE7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAE7"/>
    <dbReference type="FunCoup" id="A0A194RAE7">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAE7"/>
    <dbReference type="KEGG" id="pmac:106711733"/>
    <dbReference type="InParanoid" id="A0A194RAE7"/>
    <dbReference type="OMA" id="GLMFFTR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="22785" checksum="D2E440E5B497AA30" modified="2016-10-05" version="1">MANLKSDLDDYLLQNESRRSYKFGLPSFSRPSFLSRSNDDSPTSTSSTSTWFDNVQKEYFTLSRTQRFMGFGICMCFGLLCFILSFLYIPILLLQARKFALLFTLGSLFFIFSFSFLYGPWSHFKSLFSKERALTTSLYGSTLIATLYCALHLQSTPLTIICAVGQVLALLWMMVGYVPGGSSGMRFFGSMFKSSVSNTLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCW8</accession>
    <name>A0A194RCW8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-protein kinase ATM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCW8"/>
    <dbReference type="STRING" id="76193.A0A194RCW8"/>
    <dbReference type="InParanoid" id="A0A194RCW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Telomere-length maintenance and DNA damage repair" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="399" mass="45975" checksum="1D2F852C2567722D" modified="2016-10-05" version="1">MSLETTVKEICGNLCSNKATERKRSVETLKDYLTRNAVPDLLSDNTRKKAGFSWNDLFDIITDYLLKEAEKYESSKTFHTVTYPLCVSILHLCVAGSNKGRAYIKCDKIMDAALFVLRNKYLTNAIGDAYLSLLQKYVLPCDNYVSLITPSTWEDLLDIIVAGCLDKLYLENRLSVCEFIEKNLPLIFEFYEQNMDVKKKSQVFNLLHTSIAIHHPLGRIKNEESAQAHNWEEWNICLQSIMDLITLEISYIQKSHRHSNTLLTCANFNQVSAIMFFLTFKMSTHNIDVNCDGERAAKRPRTTVSINQTFKDLIGEFKQNHIPWISITEVYVKHFGCSLSTIDYEILLKTLQEFVSTNKINEIWCIFESLTCQVLRNLKALKDGAFIEHVNSLWMICVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD87</accession>
    <name>A0A194RD87_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF6</name>
        <name evidence="7" type="ORF">RR48_09363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD87"/>
    <dbReference type="FunCoup" id="A0A194RD87">
        <property type="interactions" value="1299"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD87"/>
    <dbReference type="GeneID" id="106710340"/>
    <dbReference type="KEGG" id="pmac:106710340"/>
    <dbReference type="CTD" id="3692"/>
    <dbReference type="InParanoid" id="A0A194RD87"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="245" mass="26383" checksum="988B58CF9EEBA156" modified="2016-10-05" version="1">MAVRVQFENNNEVGVFSKLTNSYCMVAIGGSENFYSVFEAELSEAIPVVHVSIAGCRIIGRMTVANKNGLLVPSSTTDTELQHIRNSLPDSVKVQRVEERLSALGNVIACNDYVALVHPDLDRDTEEILADTLDVEVFRQTVAGNVLVGSYIALSNRGGLVHPKTTIQDQDELSSLLQVPLVAGTVNRGSEVVAAGMVVNDWCAFCGMDTTSTEISVIESVFKLNDAKPTAITSTMRASLIDSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDT5</accession>
    <name>A0A194RDT5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDT5"/>
    <dbReference type="InParanoid" id="A0A194RDT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="10749" checksum="1E2F61891280638E" modified="2016-10-05" version="1">MAQCFGNVPHHVRNGCSGFVSGLLDAIFFLALVVLNAKRVSLDYGKARRQLIPLCPIRKQGLSALYHRIEECRVGPQDADRTARPSAPTYTAEPSTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REE5</accession>
    <name>A0A194REE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbonyl reductase [NADPH] 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REE5"/>
    <dbReference type="STRING" id="76193.A0A194REE5"/>
    <dbReference type="KEGG" id="pmac:106710022"/>
    <dbReference type="InParanoid" id="A0A194REE5"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="304" mass="34518" checksum="AE8EBC3DC1861DEB" modified="2016-10-05" version="1">MSANNENNMSDKVAVVTGSNKGLGYIIVRDLCRRGVGVVYLTARDERRGLDAVEALKKEGLNPVFHQLDVTDKESVKRFAQHLKEKHGGIDILINNAAVITNDFNKTTFEDSVNVLNANYFSILTIQEYIFPVLKDNARVLNISSDAGHISNLENPYWIKRLTSEDLKLEDINDFVNWFLDSVKNGTLKEDDFVETGILAYRISKVALSALTRVQQKQVGRGISINSLHPGFIKTNMTKNSGFLELDDAGIAPVYFVLDADQSLKGKYLWFDKTEKEWTDHKLKIHSRMDIFMEHLKMNNKDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFG4</accession>
    <name>A0A194RFG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trifunctional purine biosynthetic protein adenosine-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_08154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="76193.A0A194RFG4"/>
    <dbReference type="InParanoid" id="A0A194RFG4"/>
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        <property type="reaction ID" value="UER00126"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:adenine biosynthetic process"/>
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        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formyl_transf_N"/>
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    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
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        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_N_sf"/>
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        <property type="entry name" value="PurM_cligase"/>
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    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="10">
        <location>
            <begin position="317"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="8">
        <location>
            <begin position="486"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="736" mass="79476" checksum="6B638364B1D83CB1" modified="2016-10-05" version="1">MVLIVEPGHVEELLAMVEDPIDVIGVVEAMGKEGGHQVVVEKFQQAMEPLRAPYSGTPPLQKALSYKDSGVDIEAGDSLVSLIKPLARRVVAGIADGCRQANAALIGGETAEMPGMYPPGVYDIAGFALGVVERSHILPKINDITELLAMVEDSIDVIGVVEAMGKEGGHQVVVEKFQQAMEPLRAPYSGTPPLQKALSYKDSGVDIEAGDSLVSLIKPLARSTTRSGVIGGLGGFGGCFQLKAIEHEYKDPVLVVAADGVGTKLQVAQRANRHDTIGLDLVAMCLNDILCNGARPLTFLDYFACGALDVNVARRVVGDIIIGLPSNGVHSNGFSLIHKLMKKAGLTLEDKAPFSKEGLTLGEELIKPTRIYVESVLPALQRGAVKAVAHVTGGGLLDNLPRVIPDSVRARLNAHWWHVHPVFAWIADTGSVKDEEMLRTFNCGIGMVLIVSPEDQADERQWLRGFVDNFASALDFTRRMPLLNNKRVAVLVSGNGSNLQALVEASREPAHCMYADVALVISNKPDAYALKRAEAAGIPALVMNITRSFGAMVIGSIQARPAGGARVLVDNFASALDFTRRMPLLNNKRVFNHKEYSSREEFDRAVSGALETHRIDLVCLAGYMRILSAEFVEKWKGRLVNIHPSLLPRHPGLHAARQCLAAGDADSGCTVHFVDAGVDTGPIITQERVPVLKDDTEESLTERIHQAEHRAYPRALRLLATGRVRLSSEGEVLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGG6</accession>
    <name>A0A194RGG6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_08130</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RGG6">
        <property type="interactions" value="1420"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGG6"/>
    <dbReference type="KEGG" id="pmac:106709218"/>
    <dbReference type="InParanoid" id="A0A194RGG6"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="281"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1336"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1344"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1381"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1393"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ16539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1655" mass="187045" checksum="83C55EC881859C33" modified="2016-10-05" version="1">MGLNTTFSSTVPELASFDLDSVQFLMFSDEDIKKLSVLKITNPISFDSLGNATKGGLYDAALGPVRDRNDFCGTCSNTMLHCTGHFGHIELPLVVVNPLFIKTIYILFRISCLKCFKIQMDDKMKSILKLQLELIEAGHVTAALDLENVVGDVKSYNSETSPDKPNKLIRRCQKLLKTKDPINKTFQSKNSDKLRTKVINNFFKAINITKTCMYCRNKLIKVTTSDNKIMYNMTSDDTKGIKILMPDEIKRYCSAITQNDEDLLSYCIPVLKNSNCKPSSDIFFMHSVPVLPPSVRPCNVLRGELLEHPQTNIYKSILNSSFKARAILQVLSSSDQQKAIDGLETNPRQAYESVMGKSPPEKLHTIWQDLQKQVNYLLSCEDQTISQGLKQIIEKKTGVIRMNMMGKRVNFAARSVITPDPNVDIDEIGIPAAFATKLTYPVPVTEWNVDELRKMVINGPNKHPGAEKIEIKNGRVIRIPPDSIEKRKSLAKRLLTPDEYKTAGLKIVHRHLVNGDALILNRQPSLHKPSMMAHRARILKGEKTLRLHYANCKSYNADFDGDEMNAHFPQNEIARSEAYNIMSVIHQYLVPKDGTPLSGLIQDHVISGVKMSIRGAFFTKADYQQLVFQALSKHKGEIKLLPPTILKPVMLWSGKQILSTIIINIIPKGKPYITLTGKAKISAKAWQKENPRPWNAGGTPFNDSNTMSEAEVIIRKGELLSGVLDKTHYGATPYGLVHCMYELYGGVYSSALLSAFSKVFTFYLQWLGFTLGVRDILVTDEANKKRDELICLVRQIGRVAAAKATDLPVDVDEDTLKETIGEMLTKDPKFRPNLDRQYKSALDSYTNKINTVCLTEGLLEKFPYNNLQLMVQSGAKGSTVNTMQISCLLGQIELEGKRPPLMISGRSLPSFLPYDLSPRAGGFIDGRFMTGIQPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLAVSYDYTVRDSDGSVIQVAYGEDGLDVLKCQFLKKDQFEFLDINSNAVVSKSTINKLKEGESTKDIVKSQKSLKKWKKKHGDPFEKVRISPFTQFSILARKDIVLDEKPTDETRDPFYWELEKKWRSMSEEEKQEYERKKCPDPVISQYSPQYKFGVINEQLDGLIQNYLKNRQETDNKETTGKDKFVDIMNAKYLASMAAPGEPVGLLAAQSIGEPSTQMTLNTFHFAGRGDMNVTLGIPRLREILMTASAKLKTPNMDIPFRQNLPNLNKKAERLRQKLNRVTVADVLEKIDVECEIVTNPERQLKTILRFTFLPHSQYKTQYAVKPPQIIKHMKKFFPEMFIIIRKQAKATCGVVWVTEKEKKRRKANDDDEEGEDIVPEEKETIGKDMNDDSSDEEGPNDDDDNTEVRIRSKRAEEQEYEDPESEEEEKSDDEAIPDENQTILIDDEALEVSQNEVNPDDSRVMSEVIGSIQNATNYTYDTKSHMWCELTVLFPISFLRVDLSQALREAATKSVIHEVKNIKRAITNKEKDVLYLKTEGINILQMFKYNNILDINKLYSNDIHAIANTYGIEAANKVIIKEIQNVFNVYGITVDPRHLSLVADYMTYNGIFEPMSRKGMESSTSPLQQMSFESSLIFLKEAVLNSKTDNIRSASSCLMMGQLCKSGTGAFSLQHSAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGP3</accession>
    <name>A0A194RGP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein lark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGP3"/>
    <dbReference type="STRING" id="76193.A0A194RGP3"/>
    <dbReference type="InParanoid" id="A0A194RGP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12343">
        <property type="entry name" value="RRM1_2_CoAA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="288" mass="31594" checksum="AE9CB979A1C6F9F1" modified="2016-10-05" version="1">MVPQTKVFVGSLPQGSKPEDLRKLFERFGVVTECDIMNRCGFVHMQTEEQAAAAIRSLNNTTFNGGVITVERGRIKERGQRGGGARGGMRGGMRGSMDRRSGGPMRGGPPTRDAPYMRDARPMGPMRGGDMRGPPMGGGMPMRNGMGAPPYDRSMERPMGYDDRGYNGYGGEDRRGFALMDGRGRDQYGAPPMYDDRRGYAAEDMTGMYAEDRRAGMYGDERDMIDRRAPMRPGPMPAAYERPPPRAAPIPAADMFSRRSPPPMRGAGGVAGGYDRDPYAQQYPPMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK43</accession>
    <name>A0A194RK43_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK43"/>
    <dbReference type="InParanoid" id="A0A194RK43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115398" checksum="93724EB5EEDC4160" modified="2016-10-05" version="1">MKVHGMRAYIEPTPVPKMPAGLVELMEGLSREVLKNNPSEVYKFCAQHMRNLLVLRDGKPPKKYLTLEQKINKANNIINRRAEERRRNFDKNMQINVDQDNIEQSRGNDIEIATIVINADNLNTSKECSESREENQYISEHIIEKEDRNLESDTNIIDNGHNTTNESVVKKDNTDFKTNLSNDNGNGNNPIFETSTDPLDISHIVKQGNNIAVVNDDKINIAQTEMTIHDKSDKQLSINSEDNCNNTVQKLDVKVDNEVNPDHVDTNIKIDEMPNVVCELRTHEINVKEEKENKLDDDSEDTSRKETELNNTNDTHDASKQNCNDSGENIEENIVVTTRDSLKDDIKDINFQVKYIDMVDISTHNDKDDGTNEAIETNPETEAVNNNLEKEDMLNKKTIEGTESVSQNEAEKVENVCEINNYNYTEETDTKTIFIEAGDKVAENENQKKDIETTNELINKTLDCKSDDTILKGALVSEHKIDEMSNCKTVDAEINNDERKDHCDSNKFIKDENDSDNIILIEKETQKEDNKNHANSNHDSSQLSIKDSDDLQSKNINEPETNKLNSSKTMDLETAAITIQKVFRHFLFRSKTSSFEESTNVKFNMFGREPDAKDESDFPIHNQNKDRRVMGISRMDTVLQTVNEEKSLSLSTDDSSTISSAATVIQAHIRGFLCRNRLNRNKITSSASLNTSKESSPVSSEADPDLVKNKTVLNIHIVPEGDQFVSRDESILTSMELSLDGSPPTSANLHPLGYDKSERRKQLKREDAIQSISPPSNNSRLSEEQDSVKEVIVNEVEIGKTEEVDFEKPMNCDPVSDQQEQIKNVLNSNDKIEGINSVAAVESADSPITISNNDPLLKNKSLKKHSIEEKFKENNGFEEDKTEIEKNMAINIPEDSQRNSFIYNKESNDTGDSVKDENGAEDFIKEVLDGKEKTQQKLESERNVDSQKNVATTHDDVLKNNAEDKAVTEISSDELDVVTPFTPTEEKLNDSDKPKLLHSGEFHDVVLPTKVSRNETSVVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLP1</accession>
    <name>A0A194RLP1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13757</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLP1"/>
    <dbReference type="FunCoup" id="A0A194RLP1">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLP1"/>
    <dbReference type="InParanoid" id="A0A194RLP1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012008">
        <property type="entry name" value="Ser/Thr-Pase_EF-hand_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000912">
        <property type="entry name" value="PPEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="760" mass="86603" checksum="7A947F1DD690BE0A" modified="2016-10-05" version="1">MAPKEKENLMYFFASVACSYRTVSVDRIATIPKTRQKTPRCTRKRKDKKYVKDKSPTMFSLSEGCGCVSFRGGRRTRSMGDDSSSCRSSEIEQEVPKKLGKKVLNGECTMKALAPFLKFWKKDDVSMTKAERTMKAAILIQQWYRRYLARMEVRRRYTWTIFQSIEYAGEQDQVKLYNFFNALLSHMRDTSGRPSSERTSRTASVLEQVFSEESDEGGGVDETAPPKAARGPDIDFPLQRKDIDLLIEAFRKKKHRLHPKHVAQILKEATQMLKRLPNINVATTSISSQITICGDLHGKLDDLLVIFHKASTNGLPSPENPYIFNGDFVDRGKKSLEVLLLLLACMLAFPGGVYLNRGNHEDLIMNSRYGFIREVHQKYRHNAERLLKLIEGVYRWLPLGTIINNRVFVVHGGISDTTDLDMVRSLDRDKYVSLLRPPVAEGGAPGAEQVDKVEWKQVFDILWSDPQSTGGCVANALRGAGTYFGPDVTVSFLRKNKLSFIVRSHECKPGGYEILHNGNVITIFSASNYYELGSNKGAYLKLCGNSLERQFVQYTAAVSRTRRLTFRQRVGLVESSAMRELHSHIVMARRSLEATFRSMDLDQSGFISVSDWCYAMEETTHLGLPWRMLKDKLVRTDPETRLVRYMDTFDLNANRGGRKADTQTVVETLYKNKRSLEAIFKILDKDNSGYITLEEFSEACQLLGKYMPNPMTQEQLVDICRLMDINKDGLVDLNEFLESFRLAEKSLHEEENELAELQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMF2</accession>
    <name>A0A194RMF2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting nexin-27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMF2"/>
    <dbReference type="FunCoup" id="A0A194RMF2">
        <property type="interactions" value="1252"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMF2"/>
    <dbReference type="InParanoid" id="A0A194RMF2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000210">
        <property type="entry name" value="Putative Sorting nexin-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="95"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="486" mass="54185" checksum="ACAE5A0F044EFD9E" modified="2016-10-05" version="1">MLQRGVSGQFHYCFYYCPSTGFEIYDVETPKSISDTGNGVNVEGATHKQVVDLIKSGGDCLSLTVISVTQKEAERLEPGDESAPVGVIGGATNSRAAVYQKYDYTDKRSLPVSIPDYRVVMERNTGRSFVAFNVHMAGRHLCSRRYREFAALHHQLRKEFLGFNFPKLPGKWPFTLSEQQLDARRRGLEQYLEKVCAVRVIAESEWVQEFLTEGEESCASPVELKVLLPDRSVVAVSVARSANADHVYRAVCDKIALDNQLRPYFYLFEIVEYNFERKLQGNECPHSLYVQNYSTASASCVCVRKWLFCPRRDAALVRAHPAAAAFLFWQAVEDVNRGVISAGNRLYQLKALQEVRRAGDYLALARTLPGYGDVVFPPATTDCRATPALVLAIGWSGLKLSAWSEGSEGAGQGAGQGTGQTEVVQVSWREVREWRADDAAAAARISYRRPGSEHTTAIALYTPYYQFLCNCMDRIAEEASWSDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMK8</accession>
    <name>A0A194RMK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuroligin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMK8"/>
    <dbReference type="FunCoup" id="A0A194RMK8">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMK8"/>
    <dbReference type="InParanoid" id="A0A194RMK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000171">
        <property type="entry name" value="Neuroligin-4, Y-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="5"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="872"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="911" mass="101539" checksum="5619938A6C2712A6" modified="2016-10-05" version="1">MLRTRVIGTRYGKLQGVILPMDQHKYLKPVEAYLGVPYATPPTGSNRFAPTRAPAPWDDVKTVDQMGPVCPQRLPDISNETQALERMPKGRLEYLRRLLPRLKNQSEDCLYMNIYTPVQVGPTLQAKFPVVIFIHGESFEWNSGNVYDGAVLASYAGLVVITINYRLGILGFLNANPIPHVKARVANYGLMDQIAALHWVQQNIALFGGDAGNVTMLGHGSGAACINFLMISPTVMPGLFHRSILLSGSALSSWALVEDPVGYSIQLAKQSNCTLPDDIVKDHELIVDCLREVPLNELMSAEINTPSYLTAFGPSVDGVVVKTDYAKELLTFFIPNDLQGFTSVSGVNNFKADKRAGDRIFGIRGGQNKYDLLFGVVTSEALWKFSAQDIQNGFEGERRDRIIRTYVRNAYTYHLSEIFFTIVNEYTDWERTVQHPINTRDAAVLALSDAQYVAPLVQTGDFLSSTESGPSTFFYVFDYQTKDGDYPQRMGSVHGEELPYLFGAPLVEGLGHFPKDYTKSEVALSEAFILYIANFARTGNPNELQRQESILPISRERNKFKSIVWDEYDTLHQKYLEIGMKPRMKNHYRAHQLSVWLRLIPEIHRAGMKDVVAKHNLFRNHNDPEMYDGLVRADPLTRPNYYDPTLELYRKSYNVTLDVPSTTMDTYVTTCISVMSARPGSAVTQNQAPNSSQDASNVEVAGYTAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLQVKALQQQQKRNHNSTFDSVSSKHPHYFVGHSQSSSTIVDIDHQDKNAIIALTNRVPHFTNSNCPNVCHTGMQMTSLGQKSSPPTNRGQCTTLPRKVGFSYQQNQICNPSNCMTLPKNATFMSATNLPDVQAQTGQTQSPGNGSVLPSSPPSQHFSQKSRVPQAAMSEMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMQ7</accession>
    <name>A0A194RMQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMQ7"/>
    <dbReference type="InParanoid" id="A0A194RMQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265313" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="14237" checksum="32E448580D150675" modified="2016-10-05" version="1">MKTIYIISVIALLVVVPTTHGHLDELFIGLGNVLREIKQNIGLTLMGSNRYRNNGYPYNSYNDINMLQQENQYLKQKYEAMVHRDRRLDAEQIHVHNNNYMVMNPNNYDPDRTAAGLDLRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMR1</accession>
    <name>A0A194RMR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative glutamate receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_12629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMR1"/>
    <dbReference type="FunCoup" id="A0A194RMR1">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMR1"/>
    <dbReference type="InParanoid" id="A0A194RMR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF35">
        <property type="entry name" value="IONOTROPIC RECEPTOR 68A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="689" mass="79120" checksum="FB08C6ACA244866E" modified="2016-10-05" version="1">MNFGTAIIANVHADLDNILRDVKKHKELEHIIVDLVNSVAVREDLACVAVLCDPVYLNIFEGALFDKLYTVPFVFIVVAEHEDLLSPNFSTLEAMRQARKDGCGAYIITLANGLQAARLLTFGDRYRLLDTRAKYIMLHDIRLFKSNLHYLWKRIVNVVFLRYHNAQRNKTWFDLSTVPFPNTIKDVLITRRIEIWRNGKFHYSKDLFADKTKNLNGETLNVVYLEHVPSVVNTKSNDTKEVGGVEIEMLNTIASKMNFKLKLYQSADAEQNKWGQKLPNGSYSGLLGEMVTGQADIAVGNLQYTTLYHEIIDLSIPYTSQCWTFLTPEAMSDNSWKTLILPFKLYMWIAVLMVLLVTGSIFYGLAKYYIHLMDFRGETAKDISTEKMKQKPTSDTRPGGLYLFGEITNSILYTYGMLLVVSLPKLPSGWSIRILTGWYWLYCILLVVSYKASMTAILANPTPRVTIDTLKELVDSKITCGGWGQETKQFFLESLDDFGQKIGQRFEIINDPDAAVKRVVRGDFAYYDNKNFLKYLRVKRKNTKIDINMTNSSSTNDTGMGNTRMERNLHIMSDCMVNIPVSIGFHKNSPLKPLADVYLRRIVEVGLFEKWSNDAMYRIKTLDTNDEEIKALMNLKKLHGAFIALAIGYFISLVMFICELMHWHFIIKKDPLFDKYAIDLYYINKNKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMV2</accession>
    <name>A0A194RMV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein msta, isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMV2"/>
    <dbReference type="STRING" id="76193.A0A194RMV2"/>
    <dbReference type="InParanoid" id="A0A194RMV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF7">
        <property type="entry name" value="RE12806P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="494" mass="55753" checksum="942F232969C44EC6" modified="2016-10-05" version="1">MDAKHYNVLRDDKYGRYLVTSKELDGGELIFTDQPFAVGPKAGKYNTPPLCLGCYCPVENTLCSRCGWPVCGAQCERDPQHIAECEIFSMAKVRFQPVADWTSSAPQLDCITPLRLLLAKEKDPERWRQELEMMEVHTESRQQRPTWSMDQVNIVDFLVDHCKLGDRFSKETVQKACGILEVNAVEIPSRGGFSIRAVYPRLAIAAHSCVPNIVHTILQDNYKVEIRAAIPIKKGEPLYLCYTHALSPTIVRREYLLESKFFNCDCPRCSDPTELGTHLSTIKCNKCDNGVILSTNPLDNDAQWICTEKTCGFKTSGGAMRKMLAVVQAEVDQLDLLEPGPQAIEQREATINKYKSVFHPRHSILLSIKYALAQLYGRVEGYSIDELPDLMLERKAEYCRMVLKTLDVITPGDSRMRGMMLYELHAPLMYLARNEYSIGLITKDKLKERLQEPLQCLADAARILSREDPQSPEGITGQIAAQCLEQLKASLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ23</accession>
    <name>A0A194RQ23_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ23"/>
    <dbReference type="KEGG" id="pmac:106721677"/>
    <dbReference type="InParanoid" id="A0A194RQ23"/>
    <dbReference type="OrthoDB" id="7882129at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010629">
        <property type="entry name" value="Ins_allergen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163:SF0">
        <property type="entry name" value="GH08205P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163">
        <property type="entry name" value="PROTEIN G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06757">
        <property type="entry name" value="Ins_allergen_rp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265370" evidence="1">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="209" mass="24622" checksum="1A47185A444CF6FB" modified="2016-10-05" version="1">MKVAIVFLSVLALSLSAPQVRKVFHEHAEDFLDLIEEESGHEIMHLVEHYLEFEEFTKSLDYLSSPNFRNLVYEMESLPEFKAVIDFLEKDNIDVTYYVERLNEMIDYLQNDKRIRHTLSGKDMTAFINDCIAIFPKDKLTALYDEKIVEDEEFRVAMENLNSEEWDQVWNALWESEAFIEEANILLENGIDLKVLLREVKAVFGQFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQD2</accession>
    <name>A0A194RQD2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_07538</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQD2"/>
    <dbReference type="FunCoup" id="A0A194RQD2">
        <property type="interactions" value="1419"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQD2"/>
    <dbReference type="KEGG" id="pmac:106711110"/>
    <dbReference type="InParanoid" id="A0A194RQD2"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ20073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="43272" checksum="3054FBE3F48E5C67" modified="2016-10-05" version="1">MFKKVAVGISGGVDSAVAALLLKRLGYHVEGVFMRNWDHNYEAGFCSDEKDFEDASFVCRKLDIPLHKVYFIKEYWNEVFTVLLKEYETGLTPNPDILCNRYIKFDSFFEHCRNNLEIDAIATGHYANTSFGPHLEFYKENEGVRLLQPRDKHKDQTFFLSQVKQYALRKCMFPLANLLKTTVRDIARDEGLIQVANKRDSTGICFIGKRRFQDFIEDYIETKKGLFIDFDTGQPVGEHSGIHKWTVGQKCCLANYKHSYFVFKKDLNTNNIYVVAGTEHSALWNNLCFTTEPHWIHSEPEELQHNSVLHCYFRFQHTKPLVKCRVTKNSEGLTIFLDKRLRALTEGQFGVLYKNDECLGSAKIKNVCHNIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR62</accession>
    <name>A0A194RR62_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR62"/>
    <dbReference type="FunCoup" id="A0A194RR62">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RR62"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Reelin" evidence="12">
        <location>
            <begin position="265"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="13">
        <location>
            <begin position="457"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="11">
        <location>
            <begin position="925"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120258" checksum="AE3BC3EF384E7903" modified="2016-10-05" version="1">MSVYLTRIAVTAIRNITNKSSTLSNVVEFSPAKLFLNNKNDVFHLSRQLIVRNFATDTIQPVVALENASLPLKKKTVHKKAVLEDLTKKEGHYLTFAYATANSYDLKALKEALVQQKLYEPGKLKAHEVGDVVIANPVYTIGTEPREIIFFKEGAVVFWNCTELEASNVLDFVKRYEIESYPKDVVEREREVMTYVYQPNVKKCHLQESCFILVPDRDNSLEKYSFRHTGTKCRTQGSPDTVGIARAAKAGGICVFRLIFSCSIRMMLLLVVGLLASARGTPAPPTATCDRAPPHAQPADRYYKLSIAGDPDLYLPGELYTVSLHGVDSGEGPTPFTAFTIWAEVYKQQNENDSKDVNDTVNTTNQSLGAFQAYDAQTKLYEDCKPAIGNATAHSKTEIQVIWTAPTTTVDGCIRLCARALLAKPKNGVEERPWSVLARKLCPAPAAAVSGNRQTPIVEPCCACDEAKYEVTFEGLWSRNTHPRDFPPEVARAHFGDVIGASHTAQYRVWQEGRAASAGLRRLADDGATTALEKELKEESDHIRTIIKARGISWQQVSSGGIPSTFAVFRVDAKHHLMSLAAKLAPSPDWIVGVSALELCNANCTWTRSATLPLYPYDAGTDSGLSYTARRQPTSPPAPVRALRPDWPRDPRSPFYNQAGEMRPFARLRLSRLRLYEKSCEPTEPIGEPIPEAGGGSCATQAWGQWGPCSTTCGPGRAARQRHYIWPARALTDGCRATLTEYRHCHGPRAHCRLVSEYEAEPAESHGPCAVSAWSEWSPCEGCGVRARTRHYVVPRARKRCHVGYRARTVLSQAIPCAAGPCNKPTGKFVNATNFDWFFVDNPSGECEVSGWGEWSPCSARCGRGRRVRSRLYEPASLNTTAEDPEVERLVQERLEQCQFTLTQQEALCDGDGDCHHDGKPQDICSLPVSVGPCRGYEERWFYDKARGSCEPFGFTGCGGNANNFRTRDMCQRHCQLTLNATVKAQAVNIETILTKKLKPTPSREDNEVMVNDSPALDSDDCVTGPWLGWSDCVGDCDYAIKLNYRLIVQTGSGMGRPCQKLIKSRTCRPGNCRRLFTFTNNTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSM2</accession>
    <name>A0A194RSM2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_06084</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSM2"/>
    <dbReference type="FunCoup" id="A0A194RSM2">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSM2"/>
    <dbReference type="KEGG" id="pmac:106721476"/>
    <dbReference type="InParanoid" id="A0A194RSM2"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ20345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9931" checksum="FF45FAF1535C3467" modified="2016-10-05" version="1">MTEKFVPVVKAEEAEEEELVDPQQQLRDICSQKPDAQNLWAKYQECNDRVNSRSKTTETCEEELIDYIHVLDKCVNKDLFKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RU33</accession>
    <name>A0A194RU33_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RU33"/>
    <dbReference type="FunCoup" id="A0A194RU33">
        <property type="interactions" value="1328"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RU33"/>
    <dbReference type="InParanoid" id="A0A194RU33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19854">
        <property type="entry name" value="DSRM_DHX9_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19855">
        <property type="entry name" value="DSRM_DHX9_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000026">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044445">
        <property type="entry name" value="DHX9_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044446">
        <property type="entry name" value="DHX9_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="375"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="680" mass="76578" checksum="3C088672264FD9BD" modified="2016-10-05" version="1">MDIKSFLFTWCARRNLTPEFNIRATGPKHRQRFLCEVRVDGYTYVGAGNSITKKEAQKNASRDFINYLVRSEVLNEIEVPVDANVINQTPETTGIIANIKPDQSQNQKPVFQEGMDPQSMGQAYHAVGGPSETYTYMDRLQQQKNVAEAEDLDVNASLHGNWTMENAKSKLHQYMQMNKINADYAYKAVGPDHTRSFCCEMTIYVRDLGRNVTGRETASNKQTASKSCALSIVRQLYHLGVIEAFSGTLKKDRSGEGIMKPYPVAISPQLEQEIEETLQDLGIEPMDVESVKSESTQEGESKVVTLLQLDRAKAMREARPVPGGVVSWSPPQQNWNVWTACNIDEGPLATSSLEDISNDLEKHHRSMCQNSQLYQVCQFILDDYIASGQGAWANVCVTQPRRISAVSVSERVANERCEELGNSVGYSVRFESILPRPYGSIMFCTVGVLLRKLESGLRGVSHVLVDEVHERDADTDFALILLRDMAHTYPDLRIILMSATVDVTLFTNYFGNCPVIEIPGRTYPVQQYFLEDCIELTQFIPPPDIRKRKVSGKRVNKEEDDDEDEGLGDDPEEDLNRNCVLGNNYTQHTKDTISKMSEKDLSFELIEALLLYIKNLDGDGAVLIFLTGWNIIFALAKHLMRSSIFGDTSKYLILPLHSQIPREDQKKVFITPPPGITKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAV8</accession>
    <name>A0A0N0PAV8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine synthase reductase</fullName>
            <ecNumber evidence="5">1.16.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.16.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAV8"/>
    <dbReference type="STRING" id="76193.A0A0N0PAV8"/>
    <dbReference type="InParanoid" id="A0A0N0PAV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="369"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="783" mass="88669" checksum="EF2155BB87AC307E" modified="2015-12-09" version="1">MSNLHCNSDVMCSVAVDKLILVYCQNEDEEFGRTEAGEEEWHMDFMPTGYLPDSVYRELAWYAILQIQPLHHSSKHKVAAQLIWQHTLGRPHVIMESPPQSTQSEGKVSRQILAEEAAKWSREQRAAQEVLMENIKTGGNGLTVRTVISAHQKTIYIIQNSNFYKCPEGSEPDLDAYRLQANMHERKCTFGKPSIPVPVDPCIEAEIAPIEYSFHEGWMFCLGNGDRENNYFQNGTLDCGNKTKVSVEEFLRMCAIDSNIVITFEYFGDEPRKDMMHNATLCTTWDPCRLSYLYRLEPPPIELTPAFPTSTPNPCDTTVCPECLEGVTEDQGVPIEVTFLYRVLGGQVYDTSKETVYNSTEPSLPFAASCIINAGINNWRRLTADNEDCKAVYEVTFNVMGSNLNFRPGDTIGVIPTNRDGEVSCIIDHLELSDVVDCCYNININSGQKGAKIPAHVPIKSTLRHVLTHCIDLRGVVKKLFLLALSRYTKDEAEKKVIEYLCSKEGSSAYTNYILNKKLCILDLFEIFKTCKPPVEVILEHLPRLLPRPYSIVNSSSMNPNEIKICFSVMKIGYNRKGLVTGWLESLINESLEDMMGNITITDKKEMVTDKKVSIYLRKNINQFSFPDNISRPMILIGPGTGVAPYIGFLEEQLKGKERDLLNIIWLFFGCRNPNLDYIYKDELQGFKDAGVLTKLITAFSRFNDCEDKYIQDAIVSNGEEVAKLLKNGALVYICGDVNKMATQVKESFVKCLVKFSGFTQEEAEKFVCDMQKEKTYLIDSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAW1</accession>
    <name>A0A0N0PAW1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAW1"/>
    <dbReference type="InParanoid" id="A0A0N0PAW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="3"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="46771" checksum="41ABB17E3DFFEBA9" modified="2015-12-09" version="1">MVQVRISDGILEGEVTDNKYGGKIYCFRGIPYAQPPLGDLRFKAPQPVKPWNGVRDAKKLGNECYQYNVVFSKVAKQGSEDCLYVNVFSPNLKPTKPLPVMVFIHGGGFTGGSGSDEFYGPNYLIRHDVIIVTLNYRLEILGFLCLDTEDVPGNAGMKDQVAALRWVQKNISNFGGDPNNVTIFGESAGGGSVSLHLLSPMSKGLFKRAIPQSGIATAHWATGFMVKERSLQLARELGCNSKDEKEIYEFFKALPVEALVNKHITVTYAETNKEVFIVPFSIVVEKQFGNNERFMVGEPIEVLRNYGIHEGVDVMEGYTEDDGVLFLGCDKDVYKMISQANKYPEFLVPKTMSIYCPLIDQMEVGKMIKKFYFKDEDVSMDNLYNLQKYFGTESFKYPTILFQKIRSLFNKQRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB65</accession>
    <name>A0A0N0PB65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylcholine receptor subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB65"/>
    <dbReference type="InParanoid" id="A0A0N0PB65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="11583" checksum="16D98A079F7504DB" modified="2015-12-09" version="1">MRAARGWQAAVSAAPRPIARLPRALRNDGRAAAGCELMGTLAWWLTGWCLARAVAAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLRVCIKLKLSQLIDVVSPQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB84</accession>
    <name>A0A0N0PB84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB84"/>
    <dbReference type="InParanoid" id="A0A0N0PB84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="32240" checksum="360C7B5221C4907E" modified="2015-12-09" version="1">MPPADVLASQRAREQECERELRLLRELHTPDDDKCPSEEVHSNSSELEELGLVEAEDAPTKHVSVNMSNLIAQLLAHLPEGNSQFLKVYLEVLQQDSPAVIQYVNKEMLCVIETGLAEACGWVQGAAVCCVTWLCMLCLVGEAGLRGWRALHALLQHTTAQQVLEVSHAVCSAVRAPRLLLRLSDALRGPGGPARLADHLVHYALTQCESEGPEAGSWRSLTHVQLAGRSAAAGRPPPRLAAPRHRDHKDALKAGPSLPQQQQQQRQRCTSQVEASPARPVLSHLFPGRDEALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBZ3</accession>
    <name>A0A0N0PBZ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBZ3"/>
    <dbReference type="InParanoid" id="A0A0N0PBZ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="21502" checksum="8237AC1DE5D9881A" modified="2015-12-09" version="1">MTTKSYSKHKEYKEISSRGTVPYTDEQFDMMKSELLPKGSKLDSLGRGTGTREYHYEYKEEKLPGGKYDRKDYHTVEEYTIPARSLPKSAESSSYYYEKEEREIPAITTGTRTYNYETSGTSPVYSKVNSKVTKEMSQNVEELDSLLDDLQKDQERQLYKRSVHTDRLGEESRFLSRWKQCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCH5</accession>
    <name>A0A0N0PCH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease Dicer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460555">
        <property type="protein sequence ID" value="KPJ14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCH5"/>
    <dbReference type="STRING" id="76193.A0A0N0PCH5"/>
    <dbReference type="InParanoid" id="A0A0N0PCH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="53397" checksum="CAA277660974BAFF" modified="2015-12-09" version="1">MPQRVYERLMEEAMKSPLNAEPDMETCCSRFTAAEGGARLAAVANNKNIIITEHCTFVATRLLHEDAYKIRGLLSEGRQRSIFLTRSSRIAYVAYELGILTDLAIAKSANYEDVTDWKVHLEEKEVIVCTSRILKCILEDGYLNMLNINVLVIDSCHLISTDDDLKYVMRLYKECTETNRPRLLSLTYPIFTSINYDNDAIKDEEINRENKSDLKQIENNESIHNLDKTVLVNEIIDTKDIEDEKDKKGIDTITDKDGNKSNDFEESDSSKVIDKSTDEIDNSNENTIDEIIKSELKDEKIPISDITENVLDIESATDSTDRTIACMNTDKNLENIIKDKLISKEKDKKEISLGVYENVDDFEMYEKLGWKIEELEKDLNCEMDLAEDIDGGKRLSTAVSKPKEVIIEYSKQISVDNLPEVYKDLDLFMRKTIQDGIDFINEHSLIVLDEHLFGWLSEILQHVTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCP8</accession>
    <name>A0A0N0PCP8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCP8"/>
    <dbReference type="FunCoup" id="A0A0N0PCP8">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCP8"/>
    <dbReference type="InParanoid" id="A0A0N0PCP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="556" mass="64015" checksum="0A7D30C62C4B81D7" modified="2015-12-09" version="1">MLNVYRVVLQAMRGWCARWSGGGRGRLRWLAALLCWVALAAVALPRLQAPPAPRPAPPAPPARLLLQSEAAASTPAVITPALPATDTRVLTEDELRADAERRLPSLPLAYWHKHKDDKNKYYKKKDCAPFPSIYDLEFHNTYWQTLRASQGVFHLYGAYMDARNTSRIGPAVRVLAVHDRIKPTLATHCQLWFEEREAPVVVRNLEYKYVWNSKWGNYRDHVLQPYLLACVLPAEVRHLVPASVSIVENPCDRATNNLRVHYDRPTPPTPRKEFAVCVKGLDFLHEDLSVRLVEWIELVRILGADKIFFYELQVHPNITKVLDYYRAQGAVEVTPITLPGGQPNLPGLQHMYLKKKTTHKRQMELIPYNDCLYRHMYEYRWLALLDIDEVIVPLEDEDWSGLMRRVLPLAVPAAGKPARSSYHASNLYFLDSLRHEHGWEEGVPRYMHMLQHVYRTRNFTKPGQYVKAFHETERVLALHNHFPLACLGGACSSYALETRHARLQHYRADCVTALSKSCGELRAQPVRDTALWRWRGPLQERAERALRDLAFLPPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD98</accession>
    <name>A0A0N0PD98_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460419">
        <property type="protein sequence ID" value="KPJ14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD98"/>
    <dbReference type="FunCoup" id="A0A0N0PD98">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD98"/>
    <dbReference type="KEGG" id="pmac:106711025"/>
    <dbReference type="InParanoid" id="A0A0N0PD98"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="189" mass="21443" checksum="C0CBAA92980299E6" modified="2015-12-09" version="1">MLYDDFKPIVDLLLNNWTALQLAVEHGMGAPGGIKTAQLMSVYIARYCVENIVDREDLTELLEDLMDEEFDTACHDNSTKEIATLLLLYLELLKEGRHDELRARIEALPKCQIWLSVPMHSSVPPQCHGNPDDDSTSSSEDHNHDDCNDRTQNMNGGEASSSRQNNDTVEPMDEDQDPGWMVVRSRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDE9</accession>
    <name>A0A0N0PDE9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Solute carrier family 12 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_05550</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDE9"/>
    <dbReference type="FunCoup" id="A0A0N0PDE9">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDE9"/>
    <dbReference type="InParanoid" id="A0A0N0PDE9"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000037">
        <property type="entry name" value="Uncharacterized protein, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="100"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="378"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="672"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="801"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="1040"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="944"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="991"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ16471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122349" checksum="70E53FC6DCD493D5" modified="2015-12-09" version="1">MSSEKEKMATNEKKSPSNKSNCASPGKKGDTDEHGLPKDKDKAYDTNLYLYHEEMEDRPRAATFLSSLADYSNTIPTASAADPDAAKPAPPARMGTLIGVYLPCIQNIFGVILFIRLTWVVGTAGAIQGFLIVLTCCCTTMLTAISMSAIATNGVVPAGGSYFMIGRSLGPECGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWMSIFGDFTKDPDAMYNNFRVYGTGLLLIMGMVVFVGVKFVNKFATIALACVILSISAVYAGIFVNFNGNTKLQMCVLGKRLLKDINIDNCTKDVGGELHQLFCPNNLCDPYYAAHNVNIVQGIKGLASGVFFDNLQDSFLQLGQYIAYGKEPEDIEQMERPTYNQVYADLTTTFTILIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSCVLLFAGTVDNLLLRDKFGQSIGGKLVVANMAWPNQWVILVGSFLSTLGAGLQSLTGAPRLLQAIAKDEIIPFLAPFAVSSSRGEPTRALLLTMLICQCGILLGNVDILAPLLSMFFLMCYGFVNLACALQTLLKTPNWRPRFKYYHWSLSLAGLTLCISIMFMTSWFYALIAMGMAGLIYKYIEYRGAEKEWGDGLRGLALSAARYSLLRLEEGPPHTKNWRPQVLVLAKLNDDLNPKYRKMLAFASQLKAGKGLTVCVSVLGGDFPRRAGESLTARQNLRKAMDAEKVKGFVDVLVSHNIADGLSHFVQTSGLGGLKPNTVILGWPYGWRQSEDKRTWEVFLDTVRAVTAARMVMLVPKGINFFPDSTEKVAGNIDIWWIVHDGGMLMLLPFLLKQHRTWKNCKMRIFTVALMEDNSIQMKKDLKMFLYQLRLEAEVEVVEMTDSDISAYTYERTLMMEQRNQMLRELRLNKKETLGMMQNLVDYHEPNAEEKLPLVQAIVDHHHADVKTASKVRFAEPGSGEPGPEDAPSPPLTDNDEKDKDDKDEFRSSLLHIIDSMWDSPDEQSQCEGAPSPPLDADRNKEGGANGDVLNSKPNLPNITPDEGTVRKMHTAVKLNEVIVSRSHDAQLVILNLPGPPRDTELEMESNYMEFLEVLTEGLEKVLMVRGGGREVITIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDP1</accession>
    <name>A0A0N0PDP1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460130">
        <property type="protein sequence ID" value="KPJ17517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDP1"/>
    <dbReference type="InParanoid" id="A0A0N0PDP1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="16007" checksum="2E168C3407573707" modified="2015-12-09" version="1">MEGSGDNPPSSSYKRLRVMDRGGDPKMDLDVGGGGERNDSYLTFLKPNYKRLYTENSVNTEFKVFVEEPIKTDWATRAPLIFNHIFSNEIKGVTAIQQVNANKIAVIFKKQYNTANNFINNSSFLNEYEMKAFIPAAQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDW4</accession>
    <name>A0A0N0PDW4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_03852</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDW4"/>
    <dbReference type="FunCoup" id="A0A0N0PDW4">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDW4"/>
    <dbReference type="InParanoid" id="A0A0N0PDW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09934">
        <property type="entry name" value="SH2_Tec_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11768">
        <property type="entry name" value="SH3_Tec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000190">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="241"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="457" mass="51447" checksum="C3EC796833493B7F" modified="2015-12-09" version="1">MLQTKVDDTMVTKKKSKIPCLSLSSFLPALEAVTAAVTMPGGGAPPPGTPSSKPKEKQKTKVVVALYPFKAIENGDLSLEKGAEYEVVDDSQEHWWKVKDEHGSVGYIPSNYVKEKETIGLQKYEWYVGEMSRQHAESLLKQEDKEGCFVVRNSSTKGMYTLSLYTKVIHPQTKHYHIKQKESGEYYLSDKHCCASIPDLINYHKHNSGGLCSRLKTTPCDRPPATAGLSHDKWEIDPNELVLHEELGAGQFGVVRRGKLFGTRDAAVKMMKEGTMSEDDFIEEAKVMTKLQHDNLVQLYGVCSKRRPIYIVTEYMCNGSLFNYLRRAAPDQLGPALLLDMCLQVCKGMAYLERHNYIHRDLAARNCLVGEANVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYMRFSSKSDIWAFGVLMWEVFTCGKVPYGRMKNNDVVDMVQKGQVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDY3</accession>
    <name>A0A0N0PDY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDY3"/>
    <dbReference type="STRING" id="76193.A0A0N0PDY3"/>
    <dbReference type="InParanoid" id="A0A0N0PDY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14916" checksum="6E57F5E23E228868" modified="2015-12-09" version="1">MCKCVFADRTVNRLSYLDPGRQQVTESFAPVKCYEKPSAKMESSTIQKMSYQPVCAPAPQRPPWACKGQYQKPCQRLESTTVYKSSFLPPGEDCSEYMDPCAYGDCKPCECMCPAECIATDPCACTFPKAECCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEQ4</accession>
    <name>A0A0N0PEQ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEQ4"/>
    <dbReference type="InParanoid" id="A0A0N0PEQ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="95" mass="10418" checksum="F1B04B2179D17321" modified="2015-12-09" version="1">MIHNNAPYANNKYVVEECGPHGGGALGLGPAPRTGAAPPASPGTASAKTFCTKHYITYNFQCPTKIQTFLATVTLCTVWRIDKRKHFLKSYRHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PES4</accession>
    <name>A0A0N0PES4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCNA-associated factor histone-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459837">
        <property type="protein sequence ID" value="KPJ19759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PES4"/>
    <dbReference type="STRING" id="76193.A0A0N0PES4"/>
    <dbReference type="InParanoid" id="A0A0N0PES4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031444">
        <property type="entry name" value="PCNA-AF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15715">
        <property type="entry name" value="PAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA-associated factor histone-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21841" checksum="E30151AC08A993DA" modified="2015-12-09" version="1">MARGFEQLTVSLNTCEFICGSDRSSRSHSGGNPVCPRETPIWQRPITNFIVTNKAESDEKEQETPRSSKLNNSTTKIIEKDIEINSKNDTESDEEEIVKSKPKRNKILSDDEEEIPKNRELEESLVLEPLTGENSHKIDEYYQTNNKGKGKGKKSKENNNTDDVKRNLKRDLEDITFGEETEHSNKKAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I527</accession>
    <name>A0A0N1I527_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I527"/>
    <dbReference type="InParanoid" id="A0A0N1I527"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="157" mass="17503" checksum="B276F8DAD7F75F20" modified="2015-12-09" version="1">MERREELHRHCSVAKQTILTTHPSGLQTRVSVELANFDALCLHSECKAKKPIWDSPFLNRRGILGGVSGHSTPVLGRRSDAVNEGRLSQQCTPVMRRREVASPGGSPLPTRRDMDDEECCEVDNSVISGWLKFRDNKRGAEERARGRDEGRSAPQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8L3</accession>
    <name>A0A0N1I8L3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_04815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KPJ15598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="pmac:106710216"/>
    <dbReference type="InParanoid" id="A0A0N1I8L3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="383"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="736" mass="84114" checksum="D360F7EB309A25F7" modified="2015-12-09" version="1">MAFLERRRFTFFDVHNNVDGGKIAECLQDTSVSATTNGHNHIIICDVTGMAHIISRSWEILSFKAYELTITLAQQLPHDPYLVTIGDDDPGINPFIKVWDWSRSDRDPTCTRVSRAVPSHLRATPATALAVHNKNLFAVGFQDGSVSLFRGDISRQRSGKMNTLPDSGTSPITGLAFKGADKLFVVSRSATLVYRLGEERCVTLDAMGAAPQCSVLTDRQCFTVAATDAIYCYTAEVRGPCYALAGEKVLINWFRNYLIIVTNEIPTKTAPSTSTTVTKSHHLTILDIQNKFIVFSKTFDGIEAVLTEWGSFYILTKNKEMIFLEEKDLQSKLTLLFKKNLYDVAIRIASSQHYDVEGLMEIYKQYGDHLYSKGDLKSAIEQYVKTIGWLETSYVIRKYLESRHLESLVQYLEELHKKGFATEDHTTLLLTCYVKIDQHDQQGKLKEFINSKDKTIDFDVDVAIKVVRQVSVDDALSLASNHKRHDWYLKIVLEDKKEYKTALDYIADLEFDDADMYMKKYGHKLIQHEPKESTKLLKLLCTDYKPRNKPLVDEDSLSGVHREPDRALPDEYIHMFLNNSEDLIEFLEHMVSCADLKCSSLVYNTLIEHYIHVWAKAEPDDKSQKALKVYNVLKDPEANYDRDQMLIICQMFNFKIGILHLYEEKKLWRATLALHMRSGTPDVALEVCRRRGAACPQLWRDLLHASPPPPPRCLPEPLQVLGQLTHCHTTQYTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9D1</accession>
    <name>A0A0N1I9D1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460141">
        <property type="protein sequence ID" value="KPJ17484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A0N1I9D1">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I9D1"/>
    <dbReference type="KEGG" id="pmac:106708192"/>
    <dbReference type="InParanoid" id="A0A0N1I9D1"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.620:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="117" mass="13744" checksum="C875E61E84F14624" modified="2015-12-09" version="1">MASQTQGIQQLLAAEKRAAEKVSEARKRKAKRLKQAKEEAQDEVEKYRQERERQFKEFEAKHMGTREGVAAKIDAETRVKIEEMNKMVQTQKEDVITDILNLVYDIKPELHVNYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAI1</accession>
    <name>A0A0N1IAI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MOXD1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAI1"/>
    <dbReference type="InParanoid" id="A0A0N1IAI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="4">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="508" mass="57430" checksum="3597801466370635" modified="2015-12-09" version="1">MNKENCDANTGLKSWTIYLSQVLDSSGIRIHYTPRLRAHDAALLGAGIGVSALHVIPPKQRHYRTVGICGSECTKTMIPDDGITIVSVLLHAHGTAKKISLKHIRGNNELPKVSEENSYDVRYQQSRIVPGGRKFLKGDTLITECTYDSTGRDKPILGGYSATQEMCLSFVLYYPRTPLAGCYSMTPAKEFFETFGVREFYGVDMTQVENTFLSSSYVEYPNLPSDQGKESEEGGMHGDDQGVGFMKELVIKEPLEFGNKTFMAHLNEMPWSEPLSINEEMCLSFVLYYPRTPLAGCYSMTPAKEFFETFGVREFYGVDMTQVENTFLSSSYVEYPNLPSDQGKESEEGGMQGDDQGVGFMKELVIKEPLEFGNKTFMAHLNEMPWSEPLLTEQIEKTLYRGMHMTFCKKNDDSWGAPVQIQTYPNFTELTNNDTSEKSCNYKSVRLPSVTKTNAAIKLSLSLSAILFTSIKWLIARYKMFRQYNSPLEKITQNPLREKERLFEAVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBR5</accession>
    <name>A0A0N1IBR5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBR5"/>
    <dbReference type="FunCoup" id="A0A0N1IBR5">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBR5"/>
    <dbReference type="KEGG" id="pmac:106721272"/>
    <dbReference type="InParanoid" id="A0A0N1IBR5"/>
    <dbReference type="OMA" id="AKEYYDD"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ18423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="37353" checksum="0FB2DFA884C665AC" modified="2015-12-09" version="1">MGAHVSRNDFEWVHTEEPHASRRKIILEKYPEIKKLYGYDPLFKWVVTAMVLMQLLMLPLVKYMSWPVLLLVAYCFGGVINHSLMLAIHEIAHNLAFGHNRPLHNRLFGFFANLPIGVPVSISFKKYHLEHHRYQGDEVIDVDLPTLLEAKLFCTTGGKLVWLFLQPFFYALRPLVVRPKPPTPLEMINLVIQLFFDAVVVELFGLRALWYLLLGSFMAMGIHPVAGHFVSEHYMFRKGFETYSYYGPLNWITFNVGYHNEHHDFPAVPGRRLPEVKRIASEFYDDLPHHTSWSSVLYDFVMDPDIGPYARIKRKHFGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDV6</accession>
    <name>A0A0N1IDV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDV6"/>
    <dbReference type="InParanoid" id="A0A0N1IDV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873890" evidence="2">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="10613" checksum="273E369A51B9DD5F" modified="2015-12-09" version="1">MSPSWFLLSVALLLVAQYATGNLIRGKSDDGVFSSKDVPVPRDDVEGNELSIPVEPPADPQENTTKKCGEIVYLPLGLLYIFLSRLHEAVCLGLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFU5</accession>
    <name>A0A0N1IFU5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Envelope fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460969">
        <property type="protein sequence ID" value="KPJ10207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFU5"/>
    <dbReference type="InParanoid" id="A0A0N1IFU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42544" checksum="231D698E19997E60" modified="2015-12-09" version="1">MSRHNTILIELANNQHKINETLHLILDQNAYRDSSLIKYAKFAQLLDIISENIDDLLAELLRIENTLAFIRASSAHHSMLDITTLKSMLDKLKRVYNKGQILDLELREYYDIIRTGSYYADDRIVIIFKFPIVSLDIYNLYRLSVVPNKHNQALIPSYPYIATSEKYHVYIEAECPKLITWYLYEKDVGTQMRAEGDCIKKLITVQVLENSCRFHNISLTKEAMEKLDDQHFVVCFPHPTRVELFCGKTDYTSLQGSYLTTIPINCYLRTKEFTITNDNDEIKGQPLKIMKIPYDIKDQVAHVKHINLNSINLQGLHDIQEQLTFENPIQLNSLNSDTILYHTTIPFYTLACSAAMIFSPSPTVITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG03</accession>
    <name>A0A0N1IG03_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG03"/>
    <dbReference type="STRING" id="76193.A0A0N1IG03"/>
    <dbReference type="InParanoid" id="A0A0N1IG03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="433" mass="47994" checksum="69C73D0E086F9B17" modified="2015-12-09" version="1">MPENEGGVFFNLQTLLNQDYRGVNIAVYALATASLAFSIHKIRPVSKFSKASKVPDHFIKNHETLKGVYTGVQHSPVRLLINHRAPIYLPLWHSSKPPIPVKLWGVDIVSGNAVNWLECVAKGQKVTLKPMGRDKEDLVSTVLLHLPQAGTKSMETLDIGQKLVELGFAQASVPQPIKKKSLESQLAPAIISAESCAKKYRNGVWSDKLPPIPFYVTYWRKGSQMTINALIITANKFVQFLTFALKKNLMTKILFNETAVTEAQISLEHEILLHPRYFGPQLLDTVKQKLYTEVEGTCTGKYGFVIAVTTIDSIGAGLIQPGQGFVVYPVKYKAIVFRPFKGEVLDAIVTQVNKVGMFAQIGPLSCFISHHSIPADMEFCPNVNPPCYKSKQEDNVIQEEDVIRLKIVGTRVDASGIFAIGTLMDDYLGLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG36</accession>
    <name>A0A0N1IG36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG36"/>
    <dbReference type="KEGG" id="pmac:106721396"/>
    <dbReference type="InParanoid" id="A0A0N1IG36"/>
    <dbReference type="OMA" id="LADFTNH"/>
    <dbReference type="OrthoDB" id="7315582at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="190" mass="21244" checksum="A1FC5EFE0CA5F649" modified="2015-12-09" version="1">MTRVRGSWRRWGAGALLLAAAVALFPRVSQHWRISADFPLVSSHHLAHYLADFTNHPKLDPEIGAWSVEEEEGNYTWWRYTVRYECGARCAGRVRVQHAAGAASAASVRHGTAAEHDLRVLDSRCTHLPLLPWPWFCEETEFEMRIEQVGSGARLLENARGACSVPLALAGRCNMRERRASTLAALRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGT7</accession>
    <name>A0A0N1IGT7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGT7"/>
    <dbReference type="FunCoup" id="A0A0N1IGT7">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGT7"/>
    <dbReference type="KEGG" id="pmac:106710513"/>
    <dbReference type="InParanoid" id="A0A0N1IGT7"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000257">
        <property type="entry name" value="39S ribosomal protein L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="21161" checksum="6A47BD48D32600BA" modified="2015-12-09" version="1">MSNSNLFLKSGFVRAPLQNGVGRYVCQLQRIVLKFCKSHGGSRGLRDYIEQDLVDFASNNPSVVVYLKPRRHRSPVVVAEYLNGDRVWMSMHNKTHSEITKWIEVLRTQQGDVSATRLRKYQYTDYPSVQGPWTPFTYKDPKLNVAELPDPEFGANNRLPMSATEQLKIMFEKKQLEIKPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH31</accession>
    <name>A0A0N1IH31_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand calcium-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH31"/>
    <dbReference type="STRING" id="76193.A0A0N1IH31"/>
    <dbReference type="InParanoid" id="A0A0N1IH31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF0">
        <property type="entry name" value="GH12158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="85184" checksum="514D63B2E90C5E3B" modified="2015-12-09" version="1">MQVMRQAIETNSKNVNVDLILRLADVWKTCNKIRAASFRVGLNLWDWYRPLDPDGNCLLSESKFVSILAGPLRPVVGLSDAEISQLADYFRAQDGRVHYHQLCQIIHGEDASDRSRTSADCILEACPPPPEPRCHTLDMWQTRRLCCLLATIAARDLPLRPYFQDYELVAKNDGRITFAHFARILHFVGVILSPEDFNLIVRRFIKDSYTIDYVEFLKAVEAVKKEGIQGLGPAYQHPGAVLDTTLPKLSRPEVEAGRPGSLLGTEVFHPALQPPRPPRALLDVMLRVQEFVLQRRIRVSEHFRDFDALNSGRIMPQQFRRALDAMGLGSVISEQEAACIVRHYLDPNDKERVCWRTFEDDCDQVFTVKELEKHPEVDPGAMAAVIAELPASGSAAEKHQLTDEDLDQAEAVLLRIRAACKERSIDLRPIFGDYDKLRCGHVSRSVVRSALSRGGVLPAPAHMRALEARYLDDCGFNFIALLNDFSKEDDSAEKLVDDENDMLQLEERPVESATVARALPAVGTPHAAHDPAQTDIVQILAKIKGRMVREGLRPRDYLRQFDKHNELVIPRPDFYRGMASAGFVLTPLEMDTVMDVFCAPTQRRYIDYDRFCRTVGEALAQEGLERAPLLQPVPHAPPPPTNNFLNFEERSIVSKALDKLSKHHDQVSNIFEIFKDADREQCGSVPPVAVQRALSRRGVLALLSARELQLICKCFSYRRGCGDEADMSIIPFGVQVDYRALCTALELVHATTRAQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH79</accession>
    <name>A0A0N1IH79_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460254">
        <property type="protein sequence ID" value="KPJ16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH79"/>
    <dbReference type="STRING" id="76193.A0A0N1IH79"/>
    <dbReference type="InParanoid" id="A0A0N1IH79"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="78" mass="9225" checksum="3BD1D8BA864A2BC9" modified="2015-12-09" version="1">MQESRLRWSCKEEEEVCNLALHLSLTGRRSRGKLKTRWKDVVLKDMSECQVLDEDGEDRAKWKKLIRKADSTTIWDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHR2</accession>
    <name>A0A0N1IHR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHR2"/>
    <dbReference type="InParanoid" id="A0A0N1IHR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="19759" checksum="E342256AC7D46512" modified="2015-12-09" version="1">MAKMDCRGSFGHTKWRSVISAYPSGFTGAMTRQKRRSRRNAQGAPAKAARLVLGRVPVGVMLPPRYATLPLPAPYAAPPAHPAHRPRQTHSITPRDSLTRSLERIHRKRRADRDRPSDADLKRTYTGLDRAYAEQFIAVRDESRHAAERLDSLASTDTSDTAHDRDTHRDPHRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ING2</accession>
    <name>A0A0N1ING2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ING2"/>
    <dbReference type="InParanoid" id="A0A0N1ING2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9184" checksum="D2F32F1A2876B273" modified="2015-12-09" version="1">MKFVTIYMCENECTLNCTKQKLVLITPLCTLPAEVAHATMHAIGLQHKKHESFLQNEVKALMFNKDCKKRNRKMKAFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQK8</accession>
    <name>A0A0N1IQK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_01068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01029118">
        <property type="protein sequence ID" value="KPJ21198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQK8"/>
    <dbReference type="FunCoup" id="A0A0N1IQK8">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQK8"/>
    <dbReference type="InParanoid" id="A0A0N1IQK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="13">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ21198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="34530" checksum="317897745C2213B8" modified="2015-12-09" version="1">MSSSRSKTSFIDKPLSKGKGEISLALYALLFSEIVQYCQNRSHSIHELQTKLSDIGQDVGTRLLDLYFVRERNSKREIKLLNMLLFVKSTLWKVLFGKEADKLEHANDDERTYYIIEKDALVNKFISVPKDKGSLNCATFNAGIIEAVLTKSGFEYYRNPQATRETFAEDRWFKTGDIFYRDEHYNYYYVERIKLLLKYRNHQISPLEVESVIRQHPAVQDVAVTGIPDAECGELPVACVVVRTGHTVTAQEIKDLVKDNLTDTKQLRGGVIFLNEIPMTATTKIHRRKLKELVITMEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGI8</accession>
    <name>A0A0N1PGI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,5-anhydro-D-fructose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGI8"/>
    <dbReference type="InParanoid" id="A0A0N1PGI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="1484"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1768" mass="201700" checksum="7D531604DE75D9D6" modified="2015-12-09" version="1">MSEKNIESNVPGEHNIREVNDEELKEKESLINEDKAQTSTSFIDKQNESLTEGNTSEIATADDFTLSPVITVTKKEATFTKGDLKLQKVTVTEDISHTSTSNVGEEKFNRRLTYEIHTSGKQPKNTNDGAKEEKTADPDRLKTKIPISRLRQAVNKVKNDLKEKKRLEKEKDIASSSRKSSIPRLKDSKTPPPRDTYIKRKEEILTAKADEEFDRIFQELNPTEDTSLEFINTDIENVNQIENSFEEIIHAYEENKITQANDTGKIKQSRIPLLKRKSEHEIEVTKIKEKQSLIKSNSVDTKIQTSFNQDITEKRIASEQTKTYTHSNVTTEIYTVQKESNEVMNNTTNTVVFQNQTSLPKTDTQNQINSNEIKETIKVAIPNFDIQTSEGIKSNESIEKTTIDNETEDLTQDITITKNLNFDKETVSMIYKIDFTENNFDSLDMTQLNESMKRDQIDVKNDNNESNNVNITKEISHTESMSKSKQTESSSKSTKTIERTNYDENIELDIQSVSEIKANQTTDNNSLSKVTLAQSSETKENIKTNSESIKQVSLETNKTTETKTTNVSSKTSTFYVEETNSNHIIGETSKQSIKTNKSSEIKQELFLDNKKNEFGTNQSIAREVSLEGSKIINHLTSESSVTLRTGEESESTKPELLQNSDIQSESVKTSVRQVTLEGHTVALKTDVIKSGAIYMKSERNDKEKLGKLDKTENFEYDNVSSSKNKSIILDTEKLSIESSIQSLKTNESSNEKQNKNDKTSFETENLHANEEISIENLKNKRNKSTKLEELSRRYENIEFDVNSKKTSVETNKSIENKTTTYNSNEKSTDTNENIQTLEKIGHTKDQSLNKDDINDSTKSVLVSANENKAKGTVTTTLNNTQHSTISSSKYLNSESNKLTVASTKMTASNTSLNNTDTSINTRDVTKSLTNLNTQNTEDINKIYSEVLTKMNAQNKQSFGITKEINNVNSKHDKHENNIPDIDTALEEEIPILRGKVNRVIRRISSIDNMKPVDKSSNDLPKKKSVLSKIQMFERGEIDETYPKTRIPKLDSKTSRIPNTLRQTSTELRRPKIVKEIFKETNESKREITENTSKQNQVEKTAHNEFIKDESYISGDTKLNDDRSSKYTETDAKLLRTNYKQVKDVIKEINNKVTEDNSTRNKNNTVEETSDISTLSVQKSFDTKTEISINDNENKSQIQNEDFEIINKDESSKYTKIYTNNKSDKSLNINKYGSINTNIEDLTIKKFNKTNEDVFNFTPKENNSNNISNISNDITTSRHIDVTNEDSNYVPNEVKKELNTNKYINNENFIYTENKAKSLEYIRHNSTRKSYERLQSDYKDGRRDFDMRRTTSVAELEIGEVVKGRVLTEMIMRINSMEIISQGKKEIHREQPRKSSVSEKIALFEGKLPPIKTEKRKETYRMKNEKEVNVEMTEEEYTKKILQLKNVKNNYKNVDPEYLELRDCSEMPVIALGTALLDKRLIRYVVEAAIDMGYRAIDTAYIYGNEKEIGEAINNKINDGTVKREDLYIISKLWSTYHRKDLVEKACRQSLDNMGLKYFDLYLIHNPMSLLEGSDPLPKIANVLQYSEHDYMDAWRGIEDLIIKGLVRRGGVSNFNSEQVHRVMEKGRIKPVVNQVECHPYLSQERLGGFCDAYGMRLSCYGVLGSKGTPAEHKSDLPPVIDDPLVLVMAAGLGVTPGQMLIAYQLHNNRSVVIKATSAARLYENLKAQFISLEPSHLTALKSLNKNKRTYYLKGLGETHKNYPFNIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGP7</accession>
    <name>A0A0N1PGP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461186">
        <property type="protein sequence ID" value="KPJ07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGP7"/>
    <dbReference type="STRING" id="76193.A0A0N1PGP7"/>
    <dbReference type="InParanoid" id="A0A0N1PGP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="66591" checksum="2A5723A44532766C" modified="2015-12-09" version="1">MSAAIKQYVAQVTPRDPASAPACCPVRLTEQIARLRLVSCNLRGHDVNKLIEVNGTSLFSCSSEDELQRALAAARPARLVLLRDQRPTHPPHSSQPTNTFTHSEAAALRSELGALRAAAEQAERAKEGLRADNTRLTHRISYLEDQVAELLARHAQLHPVSSSDSCITVNKTKKNVTNINITTEPQQPSRPSPKSEVQVFQKGPDITAIVAKLPGLDAAEVDLPVLRPRSNASGASSRAAVSPRASPVPQRRAHSSHGAEPRAGRVRHSISHHCIHASVDYGAETDAAIRMIERNQRHMEKQRIKNERFNKSQTEDRFRSDSDLDAKDSHSTSRSCEPRHYEIKKAADRIEESIKKTNWAERKTLSIIEQLKKSQRLRKMKKNDSSEDIQLESDRHYTYHRIDGKVLENAHKSSRRSSKVHCRSAKSSEFESECSDYPNGEMYSSSPRLDYGSESCSTRTSHYKRGEERREEGRSRPTPPRKPLRLSLHKARSAHSILNGSESETPSRPPSEACTGDGGPDSPHKRPVKRTYAADRWAREKIRDPARATPRPQRKLLHGLSACEAPAADDLYPQSMHAPAPGSAPPRPNGLVHTGKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGR5</accession>
    <name>A0A0N1PGR5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGR5"/>
    <dbReference type="FunCoup" id="A0A0N1PGR5">
        <property type="interactions" value="1524"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGR5"/>
    <dbReference type="InParanoid" id="A0A0N1PGR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="377"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="681" mass="76838" checksum="18875E30CA0DBBB9" modified="2015-12-09" version="1">MTNATIQEIEGIDDYWGPAFRSVYEGEGGHEAFLQQLDERIKQHDKEIEKLCNFYYQGFIDSIRELLQVRSHAEELHAEISNVDSNVKETTDSLCSRAEELIRARRVELNIAATIEKMELCLPLLTTYSKLKTQVDAKRYYPALKTLEQLEHVLLPRVGPYKWCSQISADIPRLRQAIQDASMADLRDFLENIRKLSPQVGAMALKQTQDMLGRSLENIVKNKKEMMGGLGKDNIGPQCPHELVDFSPLHRCLHIHSVLGAKNDFIQYYRAQRKQQARLVLIPAVGNLHDSIQGMKSYLSAVLGFFILEEHLLTTGAGLVSKDWLLDTWSMSVSKVASTLRTNTSLITDPTLMLSIKHQIMLFINTLKCYGLPPEPLPPVLQEMAEHYTEVLMQRWVGVFRDILDNAAFLPIEVMDQEQYDGVMDTFPYDGDELETQPFPRKFPFSTVVPAVYVQVKEFIYAWLKYSAGLGLGGGRRAAQARHSASLLLSRSFTGCLSALFRRPLPLMQLVQIIVDTQYLEDATSFLYEFISNITGSELVTTQAAGSMFQAARDDAEQQICNNLEKKVDEFLDLENYDWLLVEPTGQASAFVTDMLSYLSGVLTSLEQLPERARVAAVRAATNRIATRLRNLLMDPAVKQISSGALYQLDLDVIQCEQFAAGEPVPGLKEGELLEHFASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH03</accession>
    <name>A0A0N1PH03_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461069">
        <property type="protein sequence ID" value="KPJ09871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH03"/>
    <dbReference type="STRING" id="76193.A0A0N1PH03"/>
    <dbReference type="InParanoid" id="A0A0N1PH03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="615" mass="67379" checksum="1B3478C56B1925C7" modified="2015-12-09" version="1">MASVTCLTNGNISTISGDLPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPLYARRPFTPGAPLRPAPFYARRLFTPDAPLLPTPLYSRRPERSPYPNAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHL5</accession>
    <name>A0A0N1PHL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur protein NUBPL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_02542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ19983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1PHL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="24181" checksum="454C0DA10878FB1A" modified="2015-12-09" version="1">MRKPIHWSTWRERFHPKPFLAALTLLNYQCANMSMGLLVSGENAVVWRGLMVMQALDRLTRHVAWGPLDCLVVDTPPGTGDTHLSLAQNLPIDGAIVVTTPQSAALQVTKRGVNMFEKLKVPIIGLVENMSHAMCSKCGTKNFIFGNETKKTANEMGLDIIESFEVDANMSECINSGKPAIYALPDSIHAEKYRRLANRVFKYISDKDINHAKAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHT6</accession>
    <name>A0A0N1PHT6_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">Melanotransferrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHT6"/>
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        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PHT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSFERRIN_LIKE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879777" evidence="3">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="4">
        <location>
            <begin position="41"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="53303" checksum="AA38F9762D9E4434" modified="2015-12-09" version="1">MAAVYSFVILLLIGFGEAYYYNDNLSQVLLQKEKEKNLELVTWCTTSVLEQEKCEKLAKAVMQDKGLFGDDYREIACKRAFDTEDCMIWVDQGEATLLALDAGEVYIAGRYHSLVPIAQELYGNGEPYQYSVAVVRKGSLPSVQPSTGLHGLRGARACFPGVGALAGWVMPVHILMQEGGLKITDCNNHIKSAVDYFGDSCAPNSLKDIYNPIGDNPDKLCKLCSGGAGIRCTLADPYAGYEGALKCLVDNNSGDIAFVRDTTIQHALLSHKILGGVSEDSFELICRDGSRAPVTSWEKCNWGRIPADAVVTSSAASQEQRKSYQNLLQKMVQLYGEPNPSNKNPNNTFGQQNRDQYGNPFSSTERDSYDTYDPYRRNRFNYDDKQDNDENSFSMFFSQPPYADLIFSDAAVRLKPLAHSKRSAETIAGPALLRAARIVSCDAPQASYYVAPDPEFLSHSYRTYIMGHVLAITLFMVVLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHX9</accession>
    <name>A0A0N1PHX9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PHX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1388" mass="157751" checksum="7E90AFA7424FF94F" modified="2015-12-09" version="1">MAMFRSSPRDVEYRPPNKKSYGTNAETYFCNICFDGWDSETEVEIHRSLAHKREIMNLMKNSRATYCCRLCVKPHLTYEGLIKHIKVNHLLSDENATRIEREIFICDTCSVLFFNKLLMQIHIITFHMGVDKDATFAACPKCYKMQRIKTMWYHFQGHRIQSVSCCKICLEKFKNRDELKEHMKQHKKYLYCEICQYESKNETYFQEHLSTRHKITKSINLKVDKRNWKDYFVPRTFGEYKTSIIMDIPMKGVSLAYLEEHNVRVCILCREICIGEQGMADHMQNHYLEKVNKQYEHICSCGQKFSTIILLKHHILKNKEGHCKMDSKDDENMEELMRLMDAELGEGQSEGTGRGPPLPLPDAAALDWATLVHTATRAMLQICEEHQYPTMDNLESLDNPANEPLQDTWPEPPISETSISTVMSNSPSVSINASVVGGASAVGGASAVGGASAVGGVNAVGGEGRVYCQDAHASPWIPLGYSCPVMCQNIINAIEKLKIIDYKKVLDDDKKQRLKMNNSFMNSIKNNIDTSEERTDNENTKENSYNKLWKQKNRKKILRMKNFNVNEEKNKYLNDHKDISIDNNIVEFPNERYKKAPKQDGDYQPSVNSLTYFEQIQHKNNKIVDISEFHGDHFEIELKRIFENRTCDWFKSKQPYILIKKIIRKCNTEYRRKGYGEDFLRTLTRTMNRFSKVSFEFTEDMVEVVMDSFFSLFDPSEGGQAKQSNKKHQKSDADTKKNPDAPKGRRKGRRSHAKQETQPEESSFLCEPDLSTELLVKDCSYIENYMEVKKDDDTKLDKPKRRNSGRKYRRKKNKISPTKDISPSWIDAEESEDPKNWNNQSPVPKMYDENIGKNVNDLGKEDYKKNRRKDFEKVGLLDKEKSGYLDRAVYHNVIDKLEKVGLKDEMYLAGDFNDEDLENDFFYSSDDMEDYFDDDTTSDSEDSGEECYGSLPPEPRFGNVEYKLQLVEPCERRFQHLVTQLKWRLRSGGGSAVYVVGVRDCGALRGLRARALRASLRALRRMAAALGAAPVAARARRSSLADTQQSVELRIAVLGANEAGKSTLIGVLTQGELDNGRGSARLNMFRHLHEVKSGRTSSLSHEILGFDAQISATAGITRITEEHIALLIALELPFFAVISKCELCPANVRPLVQRLEELLAPEGETTFKKKKPVLITDENMARNCVAPQQSILDSIDKCSDDEDKKDDSCIEQVAVFPVSCVRGAGLNALHAYLLALQPPIPDLQPQQDDETCEFQIDEIFHVGDSSGPVVGGLLARGQLYEGDNLIIGPLENGEFVEISVKSIYRNRVPCGSVRAGQSASLGLDRAPPVLRQGMVLLAVPPGYRAPHERPTFGTCGCRTGGIMSGNSEHGAGETASILFRFARCPEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJE3</accession>
    <name>A0A0N1PJE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Round spermatid basic protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJE3"/>
    <dbReference type="STRING" id="76193.A0A0N1PJE3"/>
    <dbReference type="InParanoid" id="A0A0N1PJE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130471" checksum="DE3216ABCB3A38A5" modified="2015-12-09" version="1">MASNEHLESHVKLSENRSLSEDNCNSSSAGDAGEGVKRRRVTHDYKKLCKLGYDPSMSTESTHASIDSKGKKRKRSKDSQEVCVWGENSKPPKMSKIWPVFDSGGYGDAAMLTLHVVQKSPNIVNPLLFHQDKDHSLLDINQTPFKEDWFGGINALLMQTRLEHTIPRDDVTKRIFSSVSRQLKIINAHFQTSMPRYKYPRVTRSNILLEHTNPRRPATHFSLALRAIKFQPTPRRELPCYGNLELPLKIKPEKGSSSQVFPAICTGIKMDPDKVQSEVIVKVEHDKVKIDRDREKVKEKDRDKDRSHSSRHSSCQQCRRRARVKRCSIGVQCRRERSAPVWGPRAPCVDIKGLKYQRLMRVETHPNGGASVVYLYQHDIDMLSEHQQESLAKEFLKLVFSEDSGGWAQFVCGVVRGAAGRLPCLLQYLAERHPSLTVKAGVLARASDIETTTISRYYQQVQQTYAAGTFRCGPLHQISLVGTVHEEVGGYFPDMLAMLAECPYLKLTMPWGPMAAVEMEPQESNDGPILWIRPGEQLVPTAELGKSPIKKRRTGINELRNLQYLPRWSEAREFLFEDRTRAHADHVGHGLDRITTAAVGMTGINELRNLQYLPRWSEAREFLFEDRTRAHADHVGHGLDRITTAAVGVLKAIHCGDEGDRGRITKDVVAFHAADFNKLVQLLQLDLYEPPISQCVTWLEEAKLNQLRREGVRYSRLPLCSDDVYFLPRNIIHQFRTVSAVTSVEPKKSSATKHKSGVIEMRALSAKYKEKPTLKLTDRKSTEVQTHKHVEDKKEKKSESRHERSDRSEQKTSHRHRDSDKHRSDKSEKSEKVEVKTDKDVKAAEKSETKTTKSEIKTEKVEVSDKTSKQIDKLDVTVPDKVVVKLENRLSDKVDSKCADSLVNKPEKSIEKIDTAIDKSESKDKSNVKLDKTENRLSDKCDKIKSQPDTEKTEKIDKSDKSTEKSESRLSDKSDSKLSEKTDRTSDKPEKSDSRSSEKSDKSDRTSEKSDKVESRLSDKSDKSDSRLSDKSDKLEGKSSDKSESRSLDKEESKSDKIDRSEKLDTKNKSDRESRSSKSEHKRHSSSRSHRSHRDHKDRSHKEHKRDHRSDDRKCSDRHRERDSKVEAKLLSAKLQEIVHRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJR2</accession>
    <name>A0A0N1PJR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_00254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01010022">
        <property type="protein sequence ID" value="KPJ20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJR2"/>
    <dbReference type="STRING" id="76193.A0A0N1PJR2"/>
    <dbReference type="InParanoid" id="A0A0N1PJR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11822" checksum="D2703DA482959BCA" modified="2015-12-09" version="1">MILYPFQEPTLYIVKGMCILDNEGNRILAKYYDKNILTTTKEQKAFEKNLFNKTHRANAEIIMLDGLTCVYKSNVDLFFYVMGSSHENEVFIRIVMSQPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKN8</accession>
    <name>A0A194QKN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKN8"/>
    <dbReference type="InParanoid" id="A0A194QKN8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="12968" checksum="30AA89EB65963760" modified="2016-10-05" version="1">MVYVNLPAVASHGSAAGRAAALSATAAAVAPVTASVSATVTAPAPTTPASATAPAPSTAAFATGGWSAAAATARFLLLGLGQRQSPSRLPEGGPPPPPPRPPPPPPRPPPPPPPRPPRKPPPPPPPLAPPQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKQ6</accession>
    <name>A0A194QKQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKQ6"/>
    <dbReference type="STRING" id="76193.A0A194QKQ6"/>
    <dbReference type="InParanoid" id="A0A194QKQ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF61">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ05979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="856" mass="98127" checksum="0E8C621E1E212556" modified="2016-10-05" version="1">MELVKHTNKPAKNSPVSRARTSSSLSAHTSTSRDIPKCTMGSMFRSEEMVLCQLFVQPEAAYISMYELGEAGIAQFRDLSLLVMFRDLFFRTSSPFESNMINGQSLKKLLNPHVNDFQRRYVSEVRRCSEMERKLRYVRGELPEPPPPPKPSPTLLSPREINILEERIDYVESEIQEITRNAQNLKTDYLSLKELKLLIEKTQTFFQDHSHHRKISASVQVYNNEGVLGHLGFIAGVVATPKVASFERMLWRISHGNIFFKQAQIDEPLKDPVTGHELQKTVFVVFFHGEQIKLRVKKVCNGFQATLYHCPATYKEQQEMLAGIVSRIKDLEIGHELQKTVFVVFFHGEQIKLRVKKVCNGFQATLYHCPATYKEQQEMLAGIVSRIKDLEIVLEQTEQHRRLVLANIARDLSTWLVAVRREQAIYHTLNMFSMDIVKKCLIAECWVPRIDLPILQKALDNGVKASGSPIPSFLHHVTTHETPPTFNRVNKFTSGFQNLIDSYGVASYREVNPALYTIITFPFLFAVMFGDVGHGLIMTAFAAIIIILEKRLAKKKTDNEIWNIFFGGRYIILLMGIFSIYTGLIYNDMFSKSLNIFGSSWKNTYDNETLVRHRMLELDPAIAYTQTPYPFGLDPAWQFAANNIIFLNSFKMKLSIIFGVIHMAFGVTMSVVNFNFFKRNYMIYLQYIPQILFLLLLFWYLCILMFMKWTMYSAVSPDPAYGTYCAPSVLIIFINMMLMKKSESRPPCPQHMYAGQEPLQKTFIAIAFLCVPIMLFGKPVYQMIADKKKKQYQQGVESGDVAEKDPHDGGMGEVLITQAIHTIEYVLGTVSHTASYLRLWALSLAHAHYVLHLCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM50</accession>
    <name>A0A194QM50_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 151B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM50"/>
    <dbReference type="InParanoid" id="A0A194QM50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="635" mass="72285" checksum="90D7EB4FCE310EC4" modified="2016-10-05" version="1">MREINNRPRQQSLGGVLRREGNWKCFLLTLMIAGCLGSVAWCNTAEIDRELIDLNTWKAICYHYVRRKRQVTRYRNGDAYTTTQVYYERVNTHSASTSFAHACCGQRDASRNLVLDSKTPITKRPRQQSLGGVLRREGNWKCFLLTLMIAGCLGSVAWCNTAEIDRELIDLNTWKAICYHYVRRKRQVTRYRNGDAYTTTQVYYERVNTHSASTSFAHACCGQRDASRNLVLDSKTPITKVRFSKGFAFANIEAASEFEDQRSRFFAEHERFDDFMEMREGLDLIGVSSFKEYMVAYREADRCPWYSSQILFWTLSCLLLSWPLRIIIECNTAYVHYTITKIFGTNYELDPSRQLDLDTHLSDTLPPVPAANYAWNLADEQSAVLSSVPRPPRTLPLSHASTVDSLELFAAIRGNCALVPSYSEAMRIDAALREEPTEDTNNPVLIDIESEQRHRPTVKAASFDEPPRRPKVRITSTHSSSNIADSTRSFDIKQNRRSWAGVLTTARSARQILEDFTNNTSPNYQLISEQQVRRNGENTLYYSRELSPTCSRDPFGGRAQTTPTDEPPPYEEALKLPALRRITRSITGTDLAGPRRAFLRDVIANRRSCLDGIGVLAGPRVIRLPQCESGEETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMD8</accession>
    <name>A0A194QMD8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMD8"/>
    <dbReference type="FunCoup" id="A0A194QMD8">
        <property type="interactions" value="1454"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMD8"/>
    <dbReference type="InParanoid" id="A0A194QMD8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="12">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="305" mass="35007" checksum="0699FC0DEA1F129B" modified="2016-10-05" version="1">MKLTERGFVKVVKNKQYFKRYQVKFKRRREGKTDYYARKRLIVQDKNKYNTPKYRLIVRLSNKDVTCQVAYSRIEGDHIVCAAYSHELPQYGIKVGLTNYAAAYCTGLLLARRLLQRLGLDSLYAGATEVTGDEYNVEPVDNGPGAFRCYLDVGLARTTTGARVFGAMKGAVDGGLNVPHSIKRFPGYDAESKKFNAEVHRAHIFGLHVAEYMRNLEQEDEDSFKRQFGKYIKLGVNADAIETNYKKAHEAIRADPSHKKKEAASKDKVKQKRWNKRKLTLAERKNRIKQKKESYIKKLKAQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMH3</accession>
    <name>A0A194QMH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Takeout/JHBP like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMH3"/>
    <dbReference type="InParanoid" id="A0A194QMH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21638" checksum="A59C9A13281CAA4D" modified="2016-10-05" version="1">MEAGHMGMKPVDPALINSVVVAMPEKGVSMLLRNINVTGAKWTKLADRILNPFGTKSSVKFLSDLHVTGELTMSMARLTTPFIASITMDMQDVQSNITYVLTGQSTFNNDDYFIIGPERIAVRNSRMPTFFLQPDTEETRIIELVLQTNQSILDHLANEVVVALMRNVVDNFRLFASRVPIKHYYQYVQTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMK8</accession>
    <name>A0A194QMK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tryptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMK8"/>
    <dbReference type="STRING" id="76193.A0A194QMK8"/>
    <dbReference type="InParanoid" id="A0A194QMK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="46"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ06762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="278" mass="31579" checksum="48A6139AC7B70306" modified="2016-10-05" version="1">MFFEQYTCKLEPFVEVVTTNGTFNFIDILNENKKYQAIQDFCPLKIVGGKAVSSALVPYQVALRKPHYIGMYWDSFCGGSLVTYKYVLTAAHCIVSDKLKLIASDIRVVAGSALSGSMFLAMYFENWRSVEHYYIHMNYHTTFLENDIALLNLQKPFIKSIAVRPIRLHTADLNVSIDVGSKCMISGFGTKENNEPSAELRMVCVPILPTTKCEETYGMAYQRDFYWCVGAKGKDSCQVSRNPEHFVPTYVIRPDEKRKCQEDKSYSITSALNVIWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMR2</accession>
    <name>A0A194QMR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein bric-a-brac 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMR2"/>
    <dbReference type="InParanoid" id="A0A194QMR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF99">
        <property type="entry name" value="BROAD-COMPLEX CORE PROTEIN ISOFORM 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="50357" checksum="E3D02C6229894EAA" modified="2016-10-05" version="1">MEGTELGGDQQFCLRWNNFQANITSQFEALRDDEDFVDVTLACEGHRLEAHKVVLSACSPYFKELFKNNPCAHPIIFMRDCEVSHVRALLQFMYAGQVNIAQAQLSAFLRTADALQIRGLTDCSQHNDKKVNRKSPPSQLRNLLSAKPSHSTSSSKAVNQNVEPNAAEDHEKSASRRSARNSPDVARNNLSEEAPFQISSQMRPNNNEYSEPCTYPTLRVKTDLEAPELNNDENDILMDSGDPEKMEKCGQDFTASDLLEPKMEMMEQEASDEERSGYQQVYYNENNALANPFATLPGNVDLMGGLSTELRDEKAEEESARDIVQLRWLGARVSGADARPHTLKPATSSNANRGRGECGPAVPQCELVLLAAGGAGAGAGAGVRCAQCGRRYSNASNLRQHVRLIHEAQPAVCDTCGRSFKTPLYLRRHTLAQHPACLKPAPPPLPALRPAIHYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNX0</accession>
    <name>A0A194QNX0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNX0"/>
    <dbReference type="STRING" id="76193.A0A194QNX0"/>
    <dbReference type="InParanoid" id="A0A194QNX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="245" mass="27424" checksum="6F4CAE57F6B422D1" modified="2016-10-05" version="1">MYERATRCLSERGGAGVRRKWLAAALACLRLARPEHAFIARPAHAATPTTPTAPTAPTTMLDAQVPNIRSKALQVIGPEELAAELRAEDPESVDPVQQALQRHEPIDFDYLYPNLKNADVETLLAVTKRAISTEQFLPRWFLLRFMLLINLKNDYNFFYGFIIYNKDGNLVHAALHALGPGTPQQPRAAPLALADLLLAELDTHQHLPQYKELHDDLQLLVKEYTAAAVRISENIKLTLQFTSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP04</accession>
    <name>A0A194QP04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP04"/>
    <dbReference type="InParanoid" id="A0A194QP04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="142" mass="16251" checksum="4496E57CF926D4B0" modified="2016-10-05" version="1">MDRMCYWSYYNTRSLGYKYRNTSTNTGDGRLMDSAMAANSIKKFSDLSRAINTKIANEVEKTNLARESIKNKIEMVDSKINSILGLQRTVIALRKDLNAAENSIANILEKVEMLEKRENISYTPSSSSCHSPIRRNSMWEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQL3</accession>
    <name>A0A194QQL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative myosin regulatory light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQL3"/>
    <dbReference type="STRING" id="76193.A0A194QQL3"/>
    <dbReference type="KEGG" id="pmac:106718774"/>
    <dbReference type="InParanoid" id="A0A194QQL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="221" mass="24824" checksum="0F40F18366944CC1" modified="2016-10-05" version="1">MENDNELSPNTARTESTQDEIKKFKENLLQSVSSGNTNSLISNESELLVPPAPRSRSASRAREALCIPANVMAELDENKIFELKEAFLLFDLNGDGYIDDNDLRGTLVSLGETVDEQLIRNMLSEASQPMDFDAFVNLLGYKTLELDSEETLKAALSRWDSENSGYISEERKLVMTWGDRFTEKETDYALDEAPTIDKGGKTMIDYIQFCSQLSGLRKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRS4</accession>
    <name>A0A194QRS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Laccase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRS4"/>
    <dbReference type="STRING" id="76193.A0A194QRS4"/>
    <dbReference type="KEGG" id="pmac:106720364"/>
    <dbReference type="InParanoid" id="A0A194QRS4"/>
    <dbReference type="OMA" id="IFHLHGY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="241"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="466"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="617" mass="68884" checksum="85F92FDD58E48776" modified="2016-10-05" version="1">MEKENVNPDVIVKPNYMLMSLQRILVLFVILAGVIVVVYYTPMPEEYFENCDRECHELDWPMICRVKLVIEVYKTYSKSCNNCADGADCPPMCITADGRERGVLAANRELPAPSFHVCQNDILVVDVVHRAPAHALSIHWRGQPQKETPFMDGAPMLTQCPQPAYTTFQYKFRASAVGTHMYHAHSAADAADGLAGAFIVRQSPRLDPLRKLYDVDATEHTIFVAEWGHSMGPLAGVTPNAPNAESLLINGKGRSSEYSNAPITTFVVENGKRYRFRLMYGGGSKSCPIKFSVDDHVLKIIALDGSSIQPMDVDAITFARGERVDFVLDANKACGVYKIRVVAEKSCQENLEGVAEVVYKTLDSKNLQKTNENVNLPVNRELTTVSSDRCASDKVLCLNEIHSADKIPAKLAAAIDEVIYVPFNYSTRQISAKRVESWGQTDGFRFTYPASPLLTQGSDVSSEAICARGTNDDECVHVKNIPLRSTVELVMFDQGGESDHIFHLHGYNFYVVGIREFNTSIEKHQIKEMHEKGTLFTSTNLIDPVIRDTIVIPKFGVVALRFEADNPGYWMMRDERSAHWTRGLDFVLKVGEQSDFVQAPPDFPKCGSYVGPEYFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRV6</accession>
    <name>A0A194QRV6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRV6"/>
    <dbReference type="FunCoup" id="A0A194QRV6">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRV6"/>
    <dbReference type="KEGG" id="pmac:106718720"/>
    <dbReference type="InParanoid" id="A0A194QRV6"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000051">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 12 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ07715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="31365" checksum="20917A5D2981D218" modified="2016-10-05" version="1">MALLDLCHLNEKINLKPVDSLASFQNDVIGYSQNFMNSAQLATPPFANPVQTLAQFNSKDETGRDIKIEFDHGTTTLGFRYKGGVLLAVDSRATGGQFIGSQTMKKIVEINDYLLGTLAGGAADCVYWDRVLAKQCRLYELRNRERISVAAASKLMSNMVYNYKGMGLSMGMMLAGFDKRGAQLYYVDSEGTRTPGTVFSVGSGSVYAFGVLDSGYKWDLEDKEAQELGRRAIYHATHRDAYSGGIIRVYHISENGWVNISNEDCSDLHYKYQAEKGLSDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS73</accession>
    <name>A0A194QS73_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 15 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS73"/>
    <dbReference type="STRING" id="76193.A0A194QS73"/>
    <dbReference type="InParanoid" id="A0A194QS73"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="636" mass="69569" checksum="2E08E61CCD389D25" modified="2016-10-05" version="1">MPLMGAILADNFIGRYRSTSMIGLALIATGTGGIKPCVAAFGGDQFRLPEDNQRLQSFFSTFYCTVNLGGFMGMVVTPALRRSVMCFGDDACYALGFGFPALLVLVSIIIFIAGKPWYRIKQPRENVTLKFAACAWYACKKRLRHDPNTDGPPLDHWLDYSAEKYGQKLVSDMKVGSRWTFQASRLRSEVFGMTLMPDQLQVMNPAMVLVMIPVCSGGVWPILPDLPPLQKMFIGGMLAAMAFVSAGILQIGIERSTLQVPGHDQTGLVVLNTLGCPVEIAVRGEGIAPVETHGTALTSPLPHRNLGLTATCPYHCAGRIIKQHVVKAELHTVAGMFMPVIVGQNSDDQIRLYFMDPNKFGKSLTGKPKLKVVYVGDTGPNKNVSITVETDKRLNDIYYVSDAPVDHIGESAYMCLQPGKFKWHASSASGELSGSGEGYVRAGGVYVLCLRERLGRLDAAVLHAPNPPNELHLAWIVPQYLLVSIAEIMFAVSGLEFSFTQAPKSMKTITIAAWYVSVAFGNLIVILIAQTKIFESRASEFFVYAAALAIAMLIFWRMAQGYNTRDIEGDASSTESRPLLRHKSRIISVHSLSSTSARAYGVRTQDRQPSMWPPRAAVRLATPSSGDMRVTTLAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSF0</accession>
    <name>A0A194QSF0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSF0"/>
    <dbReference type="STRING" id="76193.A0A194QSF0"/>
    <dbReference type="InParanoid" id="A0A194QSF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="850" mass="95433" checksum="00FDC660C465F176" modified="2016-10-05" version="1">MIYFEGLPYDYEKWHNLGNPEWHPDILRKFFKKSQSLQDEKLLQNPLIRDAYGLHGPQVINTFNSTYRNLTLKVLSSYDEMGFKIREDLQTAQLLGSGIFRATAYNGRRASTATTYLSYIQNRKNFKLFKNALVLKVLIDNNNRAYGVLVKQKGKTIKIFARFEIILSAGTINSPQLLMLSGIGEKNHLEAKRIKCKVDLPGVGKNLQDHLILTIPVFSNEPGYENIEEKYLDVALYAYNRTGSWAQTSIADILAFFAKGKNALIPDFQSHLVIFPKNSTRAKNFFSIYKEPIAQTFANLIEKHSVYIFQFNLLHPYSRGNISLNSNDPFDSPLIYPNYFDDTRDLDAAIEGVQILSGIVDTGFFRNISGFLGRYNWPECNAHKTNSADYWRCIAPQIVTTVYHPVGTCGMGPDPRKCLENSCQWNYLNDTCPKPNTGDVFQDILSTFHLLVTSTCLITDKWEPSADIKDGDTFNFIVVGAGTAGCVLANRLTDVKSWKVLLIEAGGDPPLESYIPPYDQHLFGSEFDWQYKTVPTGKTNCANVGESIDWPRGKMLGGSSAINGMVYFRGIADDFKKWFDLGNNEWCADVVFKYYKKLESLQDQKLLHNPHIKDLYGLNGPQVINTFNRSDEELVKNLLESYNQIGLQKQEDLHLANLLGAGLSRDTAYNGIRASTATTYLSQIQHRENFKLIKNAFVVKILLDSNSKAYGVVVKYRGKEIKVFASEEVIISAGSINSPQLLMLSGIGEKKHLESKDIACKVDLPGVAPEIVTTIYHPVGTCAMGPDPSSAVVDSRLRVHHVKGLRVIDASIMPYITSCNTNGPTIMIGERGSDLIKEDYGIKDLNKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSG7</accession>
    <name>A0A194QSG7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSG7"/>
    <dbReference type="InParanoid" id="A0A194QSG7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264593" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9270" checksum="B3305B7DE5BA6A78" modified="2016-10-05" version="1">MNRYHRPPLLNYLLTYRVLMLFSILSFLCPCCGDANTTQEIPHQDIPLEPDDTSSQANLNNSSDFWRFWRTWKFLKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSN2</accession>
    <name>A0A194QSN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QSN2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSN2"/>
    <dbReference type="KEGG" id="pmac:106720059"/>
    <dbReference type="InParanoid" id="A0A194QSN2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="1318"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="698"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1639" mass="188937" checksum="52E9C0910C87B9BB" modified="2016-10-05" version="1">MMDINCSNGVYELLSELCRKTASSYTSHSRTSQTVLASKMRSLSYEIILKKSTLSIPNSRNEPIVDLLSYCFVAQNNASNVAEYKRSVELKNLINKIYKTDFEDYKEHFQNVLRLLICLQNTRKPDLETAMFQRPFSFGALDDMLPKPPRQAFGSPQPYSYYPSFIFELPYTIKKQAMVPDNEKSYTAYTVESFNSKSFIPEKTNSEVPGLYDIKSFMRPNSLRSYSSTGFESYTDNILNIPKLTAPRDLEIPSTIGSLGSNVKVSFPSSNAACTVEEMYRADKNAVDIWEIATQVDKNVPANIWNIVSKMPLVNERQIIATSTREVALWKKVNKAQLPHLKVINEKQFIRHIKYLIIGIETSSFPFSEESNCFYMKENLVLEGISKERLKGYVSDLLVVGTYYKRLSQFAFNQTVDDNFQSKGLVHEAAREVIRRYLLDFRLLATEVYEDCKDMSEELNCMPTLLDILHHIEPLKYEIETIASIYKMIDSETKSTIPYGAELMSYLFNEISLVTHKTTALTLFNSLFTVCKVYFKFIERFIFEGELDDRFNEFFIKKDNQYVNLRSKRYWDKGFYITLSVAVPDFLRSLAKYILLCGKSLRLLKLCNPSDPLVVLISSDHPTVKCCASFEELERQQQVLDVYRTRCLFVSGEPVTFDQILLKKEAERKAFTEMASLKQAETMEKIVAERKRLAQLIIAEKQHSLRVLEAAMAEAKAAKNKAKQRERKRYELEEALEKATEEVDSKLKDDERNKIMEYYSKLNMEVEKSKLHTEWKIKRLQLDQSRIQLLSTEERNLKREKLELEHKRNGEIMEMSIESLDLKSENTESGQSENNQLEFKTPDSMRSMEINENEISSNTIDNNQNVDNTKKTILNINKTDLDDNCDNKKALDSQGNVLNVDSENNRDRRDFTTSSNIIGGKLDSAIDNKTFMNMREEALKNKQKVMCHEFCQTDDENNEMNLPVIQLTSVDEENNDLSAFSEAKRNKLKVLGTEFGMDEKIKEAIVPKTDAQKEALINKRKVLGVEYNLPLENIHKKEPANVAQEEAVQNRNKILASEYNTRLVKISNQESGRKSKLTLNLKPFVESSDHLAPNTGTITPGDFFPQLDLETPTTGDVPLDSGLTCDIFTPRSDGKDIDSAKVKCDKDYLTSEGFDFSIIVDEETAASEDTTDVAIEETSDISPSKVLDNSIINIKNKYSFYNFIDGSYNFDTFDPFGVKNLQNYTKNYFSNEMNKDVKQSFYTDPAIIMEEVKKKPFHNIFVSNFISGEEKESKISTNNIATLTACLQRSVMLPLTYQLEVVNNSILTHFLVNLDMYEHLRSLKDYFFLMDGEFSRSICHNLFTKLTKTLNPQELLNFATLHNILDKALGSSISHVHKFSENLSFTIAESPLSFQHSSPDVLQCLSLTYSVSWPLNIILSQEALLRYAKVFQFLVKMRRVFWVLSEDFESLKLSAKLSREHSRKLLRSPQYISVQIYRHVMASLIRALDNYIVTTCILTSWTEFENDLKKARTLDDLYECHVVYIKKVLFRCLLNNRSTPVMKLLNDIFTVILKFSRVLKAGEWQQNEFNGSFTHTNFIQLEELYHLFEKLAKYLHKVVTKLMECGYQRHLVELLTMVNLNGYYDPEKSKEDNTNTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSY0</accession>
    <name>A0A194QSY0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSY0"/>
    <dbReference type="InParanoid" id="A0A194QSY0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="8958" checksum="68A1480F82E483F5" modified="2016-10-05" version="1">MGCIFGTLGSAFSVILDALERISTWTVCAILTCCLAVTLITVLLIGIGIGYHYCYIHYVGSGSSKCFPTACDIRHTTNLFQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTI6</accession>
    <name>A0A194QTI6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nori-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TP53-regulating kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">p53-related protein kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_12377</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTI6"/>
    <dbReference type="FunCoup" id="A0A194QTI6">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTI6"/>
    <dbReference type="KEGG" id="pmac:106717858"/>
    <dbReference type="InParanoid" id="A0A194QTI6"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ08624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="27757" checksum="0F73701D5913DF34" modified="2016-10-05" version="1">MCEELKLLKQGAEAKLFICKYLGKPTLIKERFKKNYRHPDLDSTITKERIKNEARSILRCILAEVKTPALYLVDFDRRRIYMEYMETSITVKDFIINVVKNVEENEDILNFIAKVIAESVRKMHDNNIIHGDLTTSNMLLVEKTPTKVKGDAKWLNHENLELVMIDFGLSYIDSSAEDKGVDLYVLERAFISTHNNYPKLFDKFLEYYKSYSKNNVKEILSKFEEVRARGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUI8</accession>
    <name>A0A194QUI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Locomotion-related protein Hikaru genki</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUI8"/>
    <dbReference type="STRING" id="76193.A0A194QUI8"/>
    <dbReference type="KEGG" id="pmac:106717292"/>
    <dbReference type="InParanoid" id="A0A194QUI8"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264642" evidence="7">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="177"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="277"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="336"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="395"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="53561" checksum="90283EC619FA5753" modified="2016-10-05" version="1">MILLVLVFLPLLKCFAEENVTVPQDEYKCSLPDVTSIDDNLDITRFRSDFSKISEVKFPGLIGPLNERLICKIKCIDGNWVGPLCSTTADGRFQPILRECFYRDDYKLLSISFKNSSIEKETYFPHGSIVTSKCKHFGLYKLKGESQVRCENGEWSPKFPECVPTTLVTNFTGDAPPSIQYIIVSGSAVVEPSGELFVYPESTLWLDCIIPRVSGDPDWSWTQALGQHNAAWATDDGEKETHYRLTLTKMSARHSDQYTCTSSGGHTNTVIIKVVSVVCPPINVSSPRIRLFSQGWRLGHSVHFSCQPGYHLNGSAIVNCMGNGHWSALPPTCEETFCPMLRTLGPHLSLVEYNSSYGGRAVFQCSWGYRLVGAPGLECEFDGRWSGDIPHCIPIYCPNPIVPEKGRLLTQASTKNGKYAVGDLLIYGCDEGYHVLGEQSIVCTENGFWSHPPPFCLRPSEIRKADTIYIENTTLVHFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUP4</accession>
    <name>A0A194QUP4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUP4"/>
    <dbReference type="FunCoup" id="A0A194QUP4">
        <property type="interactions" value="1413"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUP4"/>
    <dbReference type="InParanoid" id="A0A194QUP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264645" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="193" mass="21773" checksum="A39AF3A7A4C00111" modified="2016-10-05" version="1">MSKWLVILLLFKYILADPTPIVLWHGMGDTCCVDFSLGSFKIFLEKEIPGVYVLSLQIGNSTIEDFENGYFMHPNKQVQYVCQVLANDPKLADGFNAIGFSQGAQFLRGVVERCGHKLPAIKSLISLGGQHQGVYGLPHCGALQHASCDYVRKMLNYAAYYSMRQTSKWPLKFAKNNEETTVHRQPNLQTHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV29</accession>
    <name>A0A194QV29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV29"/>
    <dbReference type="STRING" id="76193.A0A194QV29"/>
    <dbReference type="InParanoid" id="A0A194QV29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="447" mass="50814" checksum="962360453045CBCA" modified="2016-10-05" version="1">MSYEKMEVVNPAEKEASEVLHSLLSVERRSVDSKEAIIVSIPADQNGGGEYGESAQWHTPVMGQHSVFELSTAQGLQQHTYNGHQEQVLWQGHTIQVENGDGNLQAMQGTYSIEFEPNVDGETGDMDVDTKPKVEKKVAVKRKKKMAESDSDEDVFDNKLEDNPAQVKERLKRGCDCKDNCYRGLNPEAVYRHRLNIAELTKSEHDMYLMGITMASLANPAETSRHKVRRRLRACYVYQGRKVCLEAFLYLENVTHYQLKRIRQHVMTHGVAPRIHGNVGKKPYNTFTLDIYKHATNFLKEYLKQHASSPKDVQPSGEGGKKTSKTVIIQGDSRKHLFEAYKEYGEILEPGVKLMGYSTFRAFMKDQFPQVKFATKKQEMPKDMVPFRSVSQQHCVQPLGVSEDSGQPVEMAQQVIPLAVVQQPQQAYLVTPVSHFQTRVQGAWYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVV3</accession>
    <name>A0A194QVV3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ejaculatory bulb-specific protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVV3"/>
    <dbReference type="KEGG" id="pmac:106716688"/>
    <dbReference type="InParanoid" id="A0A194QVV3"/>
    <dbReference type="OrthoDB" id="7182126at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264674" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="13478" checksum="2337DF9431D6464C" modified="2016-10-05" version="1">MKTILALTVLVGLAATTLAYSTEHDDLDIAAIVADKNELQKFIDCFTEKAPCTKLTQDFKSKLPEVVREACEKCNPIQKQKLKIFLDGLNEKFPEEYNALKKQFDPTGKLFEALNAALAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXD7</accession>
    <name>A0A194QXD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0468 protein C16orf80-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXD7"/>
    <dbReference type="STRING" id="76193.A0A194QXD7"/>
    <dbReference type="InParanoid" id="A0A194QXD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="316" mass="36650" checksum="1F0DDBA7F8F0E9B4" modified="2016-10-05" version="1">MFRDLYQRGMVTIFFSVGSKPLDIWETHIKDGYIRKFLDQDIKSMVYEIRGTNVSTTYIKCPKGNQVLGINMPFMIMIVKNLKKYFTFEVTILDNTGVRRRFRVSNFQSTTQIQPFCTVMPIGLADDWNQIQFNIAEFTRRAYNKQFVEVQNVKINANIRLRRIYFTERLVHPDELPNQYKLFFPIDKKAKKEKMIHPSQTEMPKVNVSKISVREQEARATIAKAPSEHSLEGKKKSKTSLKESVTKAPSEHSVEGETKSRTSVKRSLTKTSSVVEGETKSKENLTETMEDIPDQPIEAFINTLLDQEVFEKLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXP7</accession>
    <name>A0A194QXP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein furry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXP7"/>
    <dbReference type="InParanoid" id="A0A194QXP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="2">
        <location>
            <begin position="419"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="3">
        <location>
            <begin position="693"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="3">
        <location>
            <begin position="785"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1379" mass="147485" checksum="89F87D5FD44584DC" modified="2016-10-05" version="1">MEDIITFLITPAVMRIFNIVQALGSPHTWIVHQHCRQLLLNLLVAVAAHHDHLTVARTLLASRSAQLGLAPSAPSAPSAPSLPLLQHNFTEPDATFDKTTQCGHSPRATARSLSTDPQVTPEGEADKYPSLPVIITGEAEAGETEGEGGLEAGDKGEAELPVADVIKSLVHFLANRPTHMPLWQYEDITAKVWSLRSCQQMATLLRHTLRVFRESLPHALVSERWAQTALQLGLSCPSRHYAGRSLQVFRFIGVAMTGRMVTDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLESNFRPLDYMRDIFKSTPNLNNKDGGQQPNGTPFTAGKRSPGVCVGCASNHTRSTSYSVSAPYCVRKPNAPPNNADKQSHDRSRPCSDSSKGCSNLCRSRSAQSLKLLGDSATQDDKLTILATLFWVGASLLESDYEHEFLLGVRLLARVMARLPLDRPDARDRLDRTQAHAAPALHSLLLKGCTHPNTYEPVVGVLADMIPLLELPVIDPTQSMAFPMTVVALLPYMLLHYEDATELCVRAACHIAQFTAEKSKKLENLGTVMTLYSRRTFSKESFQWTKCVVKYLWDTYSHLSLQMLAFLVEVLEKGAASLQPAVLSILHCMLHYVELNAPAAQSVNADLLRAVSKFIGQDNNNYKEAMKILKLVVTRCSTLVVPPHWDSHASSILDTDLHGKKELPGRTMDFTFDLSQTPVIGRKYLPKSGSQPPTGPSSLSNASSTTPDKGSSTSGSASTVVGPESGGRCAGAGGSVAGAGAGAHSAASPRRSLSLSPADALASGWKRPWMSQSRVRECLVNLLTTCGQRVGLPKSPSVIFSQSSELLERESSMTSSLEEVSGTPGNEPSGGAPPTDHFGVFKDFDFLEYESESIEGESSDNFNWGVRRRLPSEERPAAGSGAGTSALDRSPPPQRARHHHHRLGTRTHPTRRACGRKAGRAEMRTRVEPGPGPGPGAERTSSCCVHAHTLRRLPSEERPAAGSGAGTSALDRSPPPQRARHHHHRLLGHEDSSDEEGVWEEGGARGDADASGAGAGAGGGAHELMLRTRAHSFSSASSGEPDGERGDVTPVPSGGGGGGGVSGGVAASIACVATSAALRDAWRCSVAALLRHAAHLPPVALVHRLHTVLKEVTCKTVSVCGESALGGAGAGELAAVVARLAGEEPPLLWAGPAAADCARVRDAVRFAALEINEHLETYFDRREHALEMLELSRSGEETARSLYKLIFQLLLLLETNNKMVVAVYHAALDNRGVEMSAAVCAVRNALAASAADSWGEIGEVCEGAERGEGGEVSTSSSPAPTHHDDAKLSHLMQRQRNGSHHSSGERVVAELVLHDGESVQGVCGTAASGLLMPTSANSPRAPHHKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY88</accession>
    <name>A0A194QY88_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY88"/>
    <dbReference type="InParanoid" id="A0A194QY88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23095" checksum="0F05B0D4BF259D10" modified="2016-10-05" version="1">MEAIHTKPNYVSKRNAQLYLGNISKEISNDMYKCEISTTEIDKCRLRKERCELQNEYENRYPFSKRGLRNEESELGNESIIRKRVWAVHGDARRAGNSKLKLVHGSRHWTASFGRTISGQVRVTALLGLLLLSLAASSAAPARSRSARSAYHSKSVAYFRNAIWDTKPACRIRLLAVTDGQTVGEEINGLSDEWEAFLPPSSNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZI5</accession>
    <name>A0A194QZI5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <source>
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            <dbReference type="PROSITE" id="PS51151"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ10953.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <sequence length="236" mass="25662" checksum="36F2F6480E21B66B" modified="2016-10-05" version="1">MPELTELDKATASMTEKRKEETASSDSDSDDTIPELEDAGAPGAGGITNPIAGIDIVSKAKQSRGEKKARKIMSKLGLKPVQGVNRVTIRKSKNILFVINSPDVYKNPHSDTYIVFGEAKIEDLSQQATMAAAERFKAPETAASGNDATATGTTVAPIAEEEDEEGVDESGVDEKDVEIVMMQANVSRARAVRALRNNQSDIVNAIMELTISELLPFNLHLLVFTFYDYSVLWRIS</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
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                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
    <sequence length="1976" mass="216339" checksum="864E44F64B4440CA" modified="2016-10-05" version="1">MHSGKLHYVSANPGGGAATLSGASSVYCVLGTPPQWRRYSRLLWRQGPALLLEEVLSAQTVSIIYQLGPHYVGTLQAPLPPGQNQEPLTPLVAEEKVVFGINARAMSQLTLAKIRKVYSKNDNKAIAKQLGMSSHENATPIRVLHNSAGHLMGPARCLGGTVVGYLGVRVFCPKPAAIMIDTVGGCSVLLGLIAMAQDVECLYAGVKALVCVVRSNKAAQAEMDRRKGYQTLAMLLKRKKQLLNSHILHLIFGLVGTVDSQKETSSIPNLTAFQDLICELEVWLGAPGGLIKSLLEHLLELATETAHRAHNLRTMRDLQLVSRLLYIISDASARPAATRHVLIQLLAALLAGQPRPNDLLCLGQFMAYTLPLPSQTEKGLTLVESDCEKECEGEHVILRNKCFNVLHGLLFTARNLVNTIVCEEISRVLGLDWLLSFMQENVHPTTVLWALRILVILCSGQGQPSSIMQRFREGAGNGGWLRHTEGSAAPQQAGVVLASAVRSQAHLHSALLHTAGFTLLTWLILYHLEVPELYYLLFGLMLGQPMRAVCSERAVCVDRVWSAAWGAAAPARQSPAALAARITLCAEPAVALLAAARALVHADPAPPDWLAEHPVAIVQVLFSLYNTLPDFVGIMMTAEVLTALASTLFPPHTSDDIHMPICESGDSSGASTPGSEKEVVIPSGGALTTHPVRAGVMDFLKVIVLDSLSLTVTGKSSPVIDLVLDASPPNSTSQQQVEYQTEVLTTVMENLLNTELFGTESNISNVCYLAARLVDKLWQGQLSRDPHEKVTGGLTRLASRTKVKKEESAKQRAHLPREHALAYMQDHVQLVRQAWCVQLQTAANTSAHTTRYVQAEWAGAWRELTRERGLWGPPRASPLDKWALDSTEGPCRMRKMLRRNHHFYLHYPYRPHLQHPDNKQLKYKVAQSLDSKEYYRVYQQWRTAGNSLGETDCIETSDIDMYKEEITNNRDTSLDVTNEEGSPTDLVSSGVVSRGSNNTSGEGNEDGPDVEDEDEQQSPPPDNQTLLRLLEHHEKISHMFRCARIQGLDTTEGLLLFGREHCYVIDGFTLLKNREIRDLDSCPDDYEPILPSQGIQRSNQRQCSKFLYEDIREVHKRRYLLQPIALEVFSSDGRNYLLAFPRKVRNKVYSRFTALATGMADSAAGSVAGQKRGVAVEQPAGLLASLIGDTSVTQRWLVTCNYNIAYILYSISFPYSSVNGLTDSHVKFVSIFSSIDDPLKKNATIGFINNFGQIPKQLFKKAHPSKKMSQRSSTILDPNNIIPSQGITPPEKLFFHNLENLRPSLQPVKEVKGPVGQILYTDKAILAVEQNKVLMPPAYNKYVAWGFADHSLRIGNYDSERAVFVSEAAAHACGELVACVCPSDKTIVTAGTSTVVTVWQYWARRRRLAVKVCLYGHSEAVTCLAASAAYNLVVSGSRDGHAIVWDVERGSFVRQLLPPHLAGPPPPVSALAIDDLTGDIATCSGSWLHAWSINGQLLGAADGGAGQQLLCAAFSQAREWDPLNVIITGSTDGVVRMFSIDYVAETLEEETQSQDVSIEPITNSMESELKERPAVPAQDSECVTATESEVKSDAEDQVDEAAAIKRVEELVKQMSLSQEPEGNLTKSGSESSLSDACETTSAKESARRHDEKDTCSDNDEPYREKQDVYSDDTARHYDNDKDGDSEAHGVEKEGDTGTHEGNDEDSGIERIDKEEDIGSHEDDRDVDVENVTHRSKLQKQGHVVLRRKSKANPLYRKSGGSIGESSESGSQEAGGSAGGGRDSCEGAGEGLRTSKSDTSLSDSFVMLSAPPSPSPKPARSSHAATSAEVSGEGAGAVRWRRRLVLRGKLTMHTAYERRDNASPAAVTAVAAARSGRGLAVGDARGRIFRWSAPDMSSAAGAKGGPADHWIRDDTAPFCTQCQVRFTALERRHHCRECGAVFCGRCTRYEAPVRRLRALRPVRVCQRCHDNIHGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2T2</accession>
    <name>A0A194R2T2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carnitine/acylcarnitine carrier protein CACL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2T2"/>
    <dbReference type="FunCoup" id="A0A194R2T2">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2T2"/>
    <dbReference type="KEGG" id="pmac:106714072"/>
    <dbReference type="InParanoid" id="A0A194R2T2"/>
    <dbReference type="OMA" id="VYRESGW"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF61">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="85"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="30718" checksum="DEF07C4970A64D71" modified="2016-10-05" version="1">MALDFVAGCIGGSVGIIAGHPLDTLKVHIQSGRGSALECTKALLKGGTLSTVYRGVWAPLGGIAAVNAIVFGAYGNTRRALPNPDSLTTHAAAGASAGLMQSVICAPVELVKTRQQLATAGEGMPKGAWAGARHILRIGGFKALFRGLSITAARDSPAFAIYFTSYEVMTRGNQSALRVFTAGGVAGALSWVLLYPIDVVKSRIQGDTIGRYVGAWDCFLKSIQSEGWRCMGRGLGAVTLRAFVSNGACFSAVVWTERAWQHFTPDTAVKKLVQAAAISDAVLHEPDYICDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2W3</accession>
    <name>A0A194R2W3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD repeat-containing and planar cell polarity effector protein fritz</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat fritz family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2W3"/>
    <dbReference type="FunCoup" id="A0A194R2W3">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2W3"/>
    <dbReference type="InParanoid" id="A0A194R2W3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097541">
        <property type="term" value="C:axonemal basal plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024511">
        <property type="entry name" value="Frtz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667">
        <property type="entry name" value="HOMOLOC-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11768">
        <property type="entry name" value="Frtz"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="743"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113773" checksum="074E9603154F4EAC" modified="2016-10-05" version="1">MFSYNVKFITSEETLYLKSGDFKSYKYETKKRLDETVYDAGKRNYCERRGGYWRIPKSSQLRQLESTLRDRHVVECIWVNDLLATLVFSSGVIAYTSIKPKTLDVTQILFDRYCVGKLSGQTVTGVIFSKTHLLFTHAERTATLFTFGKSIENSSHPCRLSDRDPHVQVLELGGARRAERRVSWCCDGSGIKVLLWSAASAEPAPWSPVLEDLANLHLYQIHGQQVTLIAFHQLENEVLCAELSQKNDNVVHIVEQTACHKNGVTLEWQQYDISNPEERVVHLSALRVCARRVSLPAVVRVARRSHCGHRLLATCIDGSLHIIHQATGLTHSVRAGFIPTDVRWAGELVLAVEEAGRLQCFDRALSLLHHHTKCLDLVSHFRDTRRMQVLATRDMKCGPIILALFAGGPLTLLQITHPRLLTAWIRADRTSNAVSLLRAMDWEEEGVECLRALSELVHGALRNSQQDKIVNNENAAQAALGAFLAPSVPLGTSALRFAPPVHDLARKFFHHLLRRGRIEKALSLAVDLSAWDLFADARWAATRAGVQHLAREAARAAHHYAQLHADGNTDILQLTADTAHAWIRADRTSNAVSLLRAMDWEEEGVECLRALSDLVHGALRNSQQDKIVNNENAAQAALGAFLAPSVPLGTSALRFAPPVHDLARKFFHHLLRRGRIEKALSLAVDLSAWDLFADARWAATRAGVQHLAREAARAAHHYAQLHDDDSECSESCSQCSSRTCSESEEELNGYTRNGKTTPPPLPRLPQPPQPSQPSQPTILPVPITQNEPTSTHSIRPNLHQYLERDNTIWNTELRDDTCIDRKMYEEHFKPIKNLQTVKWQSVDNMLMNYRKPLSNSNTDVQRSHLFDVIPRVQDDKVSHFKHVYQTDLREAIPTTYRYQSNITTNTNGRLYRHDSTWSGKSLEKNKVKFSDTVTVAVVSEPPSSPDTTNELADSLPLCAPHKYLANFAPAPTVPKAPTKPPTAHKLTISKVPTIAKVTTSPSPAQSPAGTTLDYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R480</accession>
    <name>A0A194R480_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA desaturase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_06415</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R480"/>
    <dbReference type="STRING" id="76193.A0A194R480"/>
    <dbReference type="KEGG" id="pmac:106714125"/>
    <dbReference type="InParanoid" id="A0A194R480"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF98">
        <property type="entry name" value="RE43130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="63"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="365" mass="42787" checksum="D7EAE3A32BE0B59B" modified="2016-10-05" version="1">MPPYQGVDNIAEMKRIASDNVQYTKRRDYEWQIVWRNVLAFIYLHVASLYGIYLIVTLKSKILTLLFAVFFGVLSAMGVTAGAHRLWAHNAYKARWPLRLFLAVMQTMAFQNHIYEWVRDHRVHHKFTETDADPHNARRGFFFSHIGWLMVRKHKDVFEKGATVDMSDLEKDPIVMFQKKTYLVVMPLLCFILPAWVPVALWGENPWHSWYVASMFRYTLSLHFTWLVNSAAHIWGNRPYDKYIGATDNKTVAICAFGEGWHNYHHVFPWDYKAAELGHYSTNFSTALIDWAAKYGLAYDLKTVSADMIRKRVTRTGDGSHPYSKETKNIEEEHHHPENPVWGWEDVDMPEEDRKLAEITNKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4D8</accession>
    <name>A0A194R4D8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4D8"/>
    <dbReference type="STRING" id="76193.A0A194R4D8"/>
    <dbReference type="InParanoid" id="A0A194R4D8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="112" mass="13104" checksum="16CB2B932A9B16CB" modified="2016-10-05" version="1">MVFTIRYPLCWIRGITRLNKIRNEFEAASVCAKSPTRCRRISCDGHITRRPMDYVNNLGLQHSLPSRRSRGRPTIRSKNVVLKIMSAYQVSDDVEDRAKWKRLIRKANPTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4T4</accession>
    <name>A0A194R4T4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Liprin-beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4T4"/>
    <dbReference type="FunCoup" id="A0A194R4T4">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4T4"/>
    <dbReference type="InParanoid" id="A0A194R4T4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000007">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="565"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="342"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="881" mass="98160" checksum="8F0705C76DCCE358" modified="2016-10-05" version="1">MRELGRGGSFVAATIAALHNRSAVEKHQAFNSLPAVAKIAIPERRSEDNFFEELSRRTSVASERPRSTASEASGRDSASVQSSEEAPPHESSPMSDREYLTEPLEEEDGRVVADYVHPAMRSYMYSPMGGDSDSPDEATVKCKTWTDGAVAPQRANSSDTESSTTSDDDSEEHEYETGCGDADYHTLTPNSRRDNSTRCDHDFKWMPSGDIMEEEAEAASLGTRPDDYNSASLDRRRRRTGSRSDRSDRDRKSRSSLNSKPPQHPSSVRASPRPRRPRNEETPPDLQRRWNSYEHFRWPEGGWYPPMCWCHGPPAPPPCCMHDRAWPSHPSLPPMPTSRSYKNDAEDRVRRLEADKESLQLQVQVLSEQIAAQTEKMADLERSLNETRQKLDDTEQRLQKEMLSRSSLETQKLELLSKLSEVRLRVVERGVLERSPPPDAAPLPRPAPPRTPPANYGRQIERNTHLYSSLPRSSVLTSEARVAFGKQNNMTACFLLKCSEKEEAVPRGSPSPSLREVRARLGSGGGGGGGGVRLEGDEFARGGLRASAPRRVNTLPRQTRDIREWDCEMTCQWLEGMGLESYVSAARAWLGAAPDSRGVLANASHATIEKELAIKHPMHKKKIILAVTDLMGGHGDPLLSKAGSLDTAWALRWLEDAGVCGARGAAADAALDGRLLHRLTHNELHTHLRVTHALHALSIRRGIQVLRENEFNPETMVRRAAEGEAPAVEGEAPSERAPADLARWSSHRVMQWLKEIDLAEYAPNLRGAGVHGGLMLLEPRFTAELLAALLNIPANKTLLRRHLTQRFNDLLGREVIQQKRNAEQTLGYQPLTATTKYKVPKKSQFSLKRKKSREDLELCELVCPLREDVSGDTASPVSLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R598</accession>
    <name>A0A194R598_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like and fibronectin type-III domain-containing protein C25G4.10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R598">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R598"/>
    <dbReference type="InParanoid" id="A0A194R598"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF155">
        <property type="entry name" value="IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN C25G4.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264926" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="63"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="301"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="534"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="738"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="849"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="951"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1507" mass="163382" checksum="DF320DFFA9985290" modified="2016-10-05" version="1">MRAAVVTTATAACVALLAALVAGDEAKVDSVESASESTGSSQEEGEWVSKEAWMRAPAGGVAVRSGEDALLTCVVLGARGRPVLWKRARDLQLLTAGGVRVTRDDRVRVLHDDSEEPIKGPGIRKGGDVWALVIKSVKPSDAGLYMCELNTEPPVRSFHRLTVISRGLTPPENQNATDTYSANIPTLSSLALAHNYTECCLAANVSASCLGFCSIQTILEGTGQDPELCQPDFPAIVKCMADGRNHVPCCVQERVPDICQDVCRGEFTPVTDNIKTHYSCATYMEKTLACIVEGIELLPSPPEDVEVEPLNEKQLNVSWNPPVENSETVTEYIVNVTTLRSFDAHLIDPSESSIKTNESKTSQSMTYKVQANKTSFVVNDLLPFTMYEVTVTSFNIHGSSLPSYSVRSLTLTPGKMKTTQVAPAPKLPDVRGCCISAGVNHYGCVEKLCDPTKTYEIDVTDLMICAPWAGATFGCLANGMDHTPCCRARGLPEPCLPLCSGNITTLDFNHFKCLRYMSAYTNCLLQGYGVLPGAPSRLHLTNIDTDYAVVHWAPPAALADTVQHYNLHYKALALDDDYIILKKVHSPYILENLESNSDYEIYVDAVNEHGVGDASPRLIFRTQSQVIEEEEISANAYNVTACCERVSLAGVCMPLCSYDAKMSDLRTLAPLCAQEFHKLLRCGAGGRNHEECCARRGVPAHCRGVCASAHAGGVNVCVPYIGNIVQCFEEGTGILPGPPRELHAVVSGEGKLFLEWAPPADGANATSYTVHWQLVGNNSQPYYYNTLQLDNKLNVTEPMARIVDLEPNATYHVFVVAANEHGTSLPSSMLLLNITDKDSEKEVSGIPSPPHSLAVSSHSATWLTLTWQPPQFSLPDEKITYTLFYKSPSQIGVANVTRIETTVPGHTLEKLAPNTQYVVWVTAHAAAGDSLPSETLLAWSDPAYPAYVEPPTVNPVNLVVEGSSMTILCIAMGTPTPTISLYISGRLVRQEVTRHMVTVIHNVTRDMDQISCYADNGYGTPMQASRKINISRRLVRQEVTRHMVTVIHNVTRDMDQISCYADNGYGTPMQASRKINISHVPTIQASGITMAAAGDSVILECRVEALPKPTIAFWRDPNGRTPVIDGPNYTIQLIDDPEDQTKYTMRLIIKKISESDEADYFCHAENAFGKTLRPVSVRLRHPAPHHNVTQCCTQMNVSSACIDACSFHLDMDNIMDRPECLDDFEKLMKCAADGSDHRGCCASWGVPRSCLELCRGGPVARSCALQHARRALACFRDAGARLPGPPRELRAHAAPTPHAVLLSWEPPLKNPQTVYLYRVFWRAYGAKVPEKLDTSETSVVLTGLRDDVKYECVVKAANDVGTSSLSAPIMFTTAGQELGAGAAAAPVSGGAASAVGGAVACVLLAALLLAAGFYYRHRKNLRLKTQGGVAFENPSYLRETNTDTLGNGSLANGNASNGGGAALGVSNSAAWRQETLQQASGAREVEPTLYEELKLGQDGAGFKRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5D8</accession>
    <name>A0A194R5D8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5D8"/>
    <dbReference type="STRING" id="76193.A0A194R5D8"/>
    <dbReference type="InParanoid" id="A0A194R5D8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="112" mass="12851" checksum="D14BB497AA4EDA71" modified="2016-10-05" version="1">MVLKLYKSDASPPVRAVLMTIEAANIPNVEMIDVNVLEGDHLKEEYLKEPLFYKGEKSFKQESLDKIKSGYEFSEKFLTKRWIAGDEFTLADIFFLASIRSSIEVQPIDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R624</accession>
    <name>A0A194R624_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R624"/>
    <dbReference type="FunCoup" id="A0A194R624">
        <property type="interactions" value="1865"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R624"/>
    <dbReference type="KEGG" id="pmac:106714795"/>
    <dbReference type="InParanoid" id="A0A194R624"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="153"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="52121" checksum="A09CCA7F6271A995" modified="2016-10-05" version="1">MAAVKTVEDNKNHVEDEEEEDDVNDTEEIEAKDPSKKKKKKKKKKKTAGTEASVENGPEPRDKVQNDSVEDVAETEEKKKKKKNKNKGKTSGKTQTNPPTIPIAELYPDGNFPEGQIMDHGPAEGIDERTAKDRFTSEEKRALDRMHQDIYQEIRHAAEAHRQTRKYIRDWIKPGMTMIQICEELETTARRLIGEDGLKAGLAFPTGCSRNHCAAHYTPNTGDNTVLEYDDVVKIDFGTHINGRIIDCAFTLHFNPRYDPLVKGVQEATEAGIKASGVDVRLCDVGAAVQEVMESHEVELDGQVYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGETTRMEENEFYAIETFGSTGRGQVHDDMDCSHYMKNFDQQFVPLRLQSSKQLLNLINKNFGTLAFCKRWLERAGASRYAMALKDLCDKGVVDAYPPLCDIKGCYTAQYEHTILLRPTCKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6L4</accession>
    <name>A0A194R6L4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rootletin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6L4"/>
    <dbReference type="STRING" id="76193.A0A194R6L4"/>
    <dbReference type="InParanoid" id="A0A194R6L4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF65">
        <property type="entry name" value="ROOTLETIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="298"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="403"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="455"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="611"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="710" mass="80446" checksum="58FD891911863525" modified="2016-10-05" version="1">MADSVQTFLAPRSRTPINQEGVRLWEQFEHQQIVTDAQTDLNEEKMNTGKIFHDKSTSTNLLNAETELALDKNTNVSDKDISPKDFVLKNWRERQLRAKHERARRRIINSVKEKFRDMQGQTNLDAYKDSYKDYNHKSIPKIVIAEDVEDTSNLNVNRGFESQLILDHVDGSFRVACCGVVGKVVGHARRFQGPGGALAQCRLAARCGRAAVTTGAEGGLRGTRTEVMPLPTREGLTTPRSARAPIGRRPSTLPHQRLKKEKAESPPEMDSPGSAGSDLRRQNEELRARLAGESADHKRRLDAYRRAQQGQAALVSRLQAKVLQYKQRCAELENQMAESTPRSEPSYHQPSKTCIALPAPVASSSSDTRRDERITDLETALRRLDEEKRKCEKLVLLCFCFSVLQYKQRCAELENQMAESTPRSEPSYHQPSKTCIALPAPVASSSSDTRRDERITDLETALRRLDEEKRKCEKLVSQNNLLREQLEESHQLNEALTNDLQKLTNDWEALRDEMAIKEDEWKDEEQAFNDYYSSEHNRLLSLWREVVAVKRFFSDLQTNTERGLYKVKNDFDSVTRDLVGTLSGYAITAYATQDIKPESHQQLPVTPSANVDTLRTELRDVTSQRDTATSELRERDARIQRLLGELQALEERCECAESLCSEANVMRSALEEVARALIHDSESDAPTRMHITSDRSPKRAVPQSANTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R735</accession>
    <name>A0A194R735_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R735"/>
    <dbReference type="InParanoid" id="A0A194R735"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="27167" checksum="EAE5636391096F55" modified="2016-10-05" version="1">MVKDGALNFAAKDSERESGEDIGNNISNVLKEVSKYCNSESNYRPPFFPPPPVTESPYDFDHHHLYQGPDTLLNDDIHPNEYYPYRVDDYVEEHRVPNYGVPYQYDSANISPSRRMQILQQQYGELPIITGTNELVNVVNNNQVAMVRIPESIVMNLVTPDQLSVLYQNNQAFDVPSTDPSVPRLIAMTTRVLSSILKAKKRFHNVIDHGVAGAENVFSGIHEAAGGIAELIGGGAHGLLDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7J0</accession>
    <name>A0A194R7J0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sodium/potassium-transporting ATPase subunit beta-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7J0"/>
    <dbReference type="STRING" id="76193.A0A194R7J0"/>
    <dbReference type="InParanoid" id="A0A194R7J0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="210" mass="23661" checksum="E94C00A5BE9C1FA2" modified="2016-10-05" version="1">MHGDYQVIDKTSLLTYSDHGIGLSATPTGLSNTPLIWYKENDEKSYQKYVKAIDELLSDDIRKRVNRTELGPCGHPPYGYGGKPCIIIRVNKHIGWSVNPIHINSTYYKDVPTHIKKLLENKQKKLFLTCDGFHSYDKEHIGKIEYFPDPPGIDASVFPLDLQGSSPLLAVQISDFTLGMSIAVECKMWYDGPTSSLHFLLYVTPKNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R880</accession>
    <name>A0A194R880_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R880"/>
    <dbReference type="FunCoup" id="A0A194R880">
        <property type="interactions" value="1195"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R880"/>
    <dbReference type="InParanoid" id="A0A194R880"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000001">
        <property type="entry name" value="Exocyst complex component 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="802"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126025" checksum="65C1F7664B42AD89" modified="2016-10-05" version="1">MSTLDEIEEEAKAAAEKMVMNMMQRPGQLEKVEQYKKRITHKKASIEAQLKSAVQGKLDGVSVGLKQLQECLDDVQQISLKMDELEELFKSVPPLVASLQAVREEDSRHSQYVTAMDSLKHIFTVPESVAKTKQWIGEGKLLHAHQCLTDLENSRDDLLYELHRLPNQSSHDKIMLKAYFEDVEMVSNLLEKQIKLILARTLNTVRKEPTVIVTALRIIEREEKKDQMALQQQTQSGFMPPGRPKNWRSKAFEVLECAVAQRIEGTRVDEREDNKLWLIRYLELTRQLILEDLRVVKTLCVPCFPPHYDIVNKYVDMYHTCLSSSLQDLVQNGLEGNEYVTLLSWILNTYPGHELMGSEELNIDVSILPPLLSEESMQKLQEEYLQKMECNYMEWMEKTLESERAEWGGERAPDAEPHTAAFHTHAPVIIFQMIDQNLQVTETISKEITFKALLLSIDQVTRYGNMYREGVIQFKNSHFADRSRVAYFTHHMITIVNNSEQLARLAQQTQARHWPPGRHDPPAEAKFDALLATFQKLRDEAAQFLLEEAFLDLEVHFDDLFTPKWLTSSIPVDTICVTLEDYFQDYNHLREKNFEYVINEAQNLVYKKYITAMLSKKMTFKTVEEAQQGANKIVKEANQIRSFFKRIAPEGVNVDWPFEVIKTLAEVLRCQDIEMVSLDLHGVADKCPDVTAEQLARLLALRGDVPRAHVRDTVTHVLATRQPPRAPSHPSLFKDIKFNDRLLAQFTLPICWWAELRAESCEQGGRGRGARASSRVVSAEASCGGMWRSMWRAGCLLLCLVPVTRQISIAEFSVPHAVQAGEDADLHCKYELAADETDKGLYVKWWWTPLNATSDQMHQLYQRIVGLEPNIIHSTIRLELLENDGIRLLNMTPADSGTYECEVSNIDEARAHQDIIVYSMGSGPQLNFSAAEDGPDEDEEEDVLVTCEASDVAPYPDISITVDGSLLSNVSENVEGPFDGLYDIVANATVTKSTVDGAEVRCELFFKNDNISHPAYVDIETFNSSGDEPTTTEVPETTTATDIVSDTLQNTRLPQAMLQELCRVFLEQSITSPEATDVNATVLSKSIVVYPIFKGVTVDKVFVVVVSFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8T8</accession>
    <name>A0A194R8T8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8T8"/>
    <dbReference type="FunCoup" id="A0A194R8T8">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8T8"/>
    <dbReference type="KEGG" id="pmac:106712303"/>
    <dbReference type="InParanoid" id="A0A194R8T8"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="367" mass="40091" checksum="66878A29ABBEFC24" modified="2016-10-05" version="1">MEKYISIKELEEAAASVLPKAARDYYKSGATDEQTLQENKRAFQRLRIRPKCLVGLTDCNLRTTVLGNEVSMPVGISPTAMQRMAHPDGEIANAKAAEKEGVIFTLSTLATSSIEEVAKAAPRAVKWFQLYIYNDREVTRNLVLRAERAGYKAIALTVDTPVFGLRRADVHNNFSLPQHLRLSNFEGFLSTKIHSSGEGSGLNTYVNNLFDKSLTWDEVKWLRSITNLPIIAKGILRGDDAVKAVKAGCSAILVSNHGARQLDGVPASIEALPEVVEAVKHYNVEVYMDGGVSTGTDVFKALTLGAKAVFVGRPALWGLALGGQAGVERMLKIFRTELEYTFNIAGTSSVADITKDMVVHESAYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R910</accession>
    <name>A0A194R910_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase Lar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R910"/>
    <dbReference type="STRING" id="76193.A0A194R910"/>
    <dbReference type="InParanoid" id="A0A194R910"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="15779" checksum="36D5FE1C71E67D87" modified="2016-10-05" version="1">MFYRHSPETFYPPEITIRPQNLQVRVNGIAAFYCAARGDPIPNIQWRKNGKRVSSMQSRYQVSGMDAAAGPGANGAVLRIEPVRATRDDATYECMAENGVGDAVTAVATLTVFEVLIVLRGDATPRLRANGTRLRNENITKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9F8</accession>
    <name>A0A194R9F8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative G-protein coupled receptor 158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9F8"/>
    <dbReference type="FunCoup" id="A0A194R9F8">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9F8"/>
    <dbReference type="KEGG" id="pmac:106711699"/>
    <dbReference type="InParanoid" id="A0A194R9F8"/>
    <dbReference type="OrthoDB" id="9970547at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265022" evidence="10">
        <location>
            <begin position="23"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="264"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="642"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="801" mass="93165" checksum="D2215DF6D2CE117E" modified="2016-10-05" version="1">MEIVNSLLLAISLCVLLWGVAGQYEWQLRDAVDEIREKIDKVTADNCYITHLDDLYLPENSVSHHPDVKEININPVFPNRTAMLHLHNMAMNRAFFWSYILQSRFIRPAINDTYDPGMMYYFLSSVADVAANPYINASSIYFSPNTSYTSSYRGFFNKTLPRFAPRAFRADDFNDPVHLQKISTLNTFHVLDLGAFEPDSLSKDYSSDYYRTNEWYFKWLPDKVDKRHDTKTTYQVEIRYANNTNETFTFHGPPGNDEIQGPVNWTRPYFDCGRLNKWLVGAVSPVADIYPRHTQFRHIEFPTYTAAVVMEMDFDRIDINQCNVSLGNDRPNRFAGTARCKLETTECEPLHGWGFRRGGYQCRCRPGYRLPSIVRRPYLGELIERATSDQYYNNFDCKEIGWVQKLPVKWEKAHPFIRALYADRYYEYVNASSGADALHTERINIFEVLNFIRGVQPHNCSKYKPTDLFLNGDIAFGAPEQFENQAKMAVRLANFISAFLQVSDPYEVFSGTRVADRPLTEDQMIGETLAIILGDSKIWSAGTYWDRNKFTNRTYFAPFAYKTELNTRKYKLEDLARLNKTEDVYTNKQWFQFLKQRWSTNFDNLEKFFLKMKLRDDELGVHLRQYEKYPTFYRAANIKHGHWTQPYYDCDGPLKQWVVTYASPFFGWDNVKVKLEFKGVVAVTMSLMALDINQCPDKYYVPNAFKGTDKCDRKSSYCVPILGRGFEAGGYKCECLQGYEYPFEDLTTYYDGQIVEAEFQNIISDKETRIDMFKCRLAGAAAIQSSFVIIIAVVALVFKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAD7</accession>
    <name>A0A194RAD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoside diphosphate kinase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAD7"/>
    <dbReference type="FunCoup" id="A0A194RAD7">
        <property type="interactions" value="1637"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAD7"/>
    <dbReference type="InParanoid" id="A0A194RAD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="20216" checksum="67310688CBA31AD3" modified="2016-10-05" version="1">MEKLQLTLAIIKPHAVKNPVAVSYIRNVIRNRFVVVRTRRVILDANKAGDFYQEHEGKFFFNRLVTFMASGNIDLHVIAHKNAIELWRRMLGPTKVYKAQFQEPYSLRGMFGISDTRNVAHGSDSTISAEREIKFFFPDFSFYEWHNNDELRYRKGQIIFNKHLFQHVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAZ7</accession>
    <name>A0A194RAZ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neuroendocrine convertase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_13526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAZ7"/>
    <dbReference type="STRING" id="76193.A0A194RAZ7"/>
    <dbReference type="InParanoid" id="A0A194RAZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265055" evidence="13">
        <location>
            <begin position="21"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="14">
        <location>
            <begin position="568"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="772" mass="86640" checksum="4D28E047B83CD533" modified="2016-10-05" version="1">MSLVIEILLFILLIYGLVLSVTSHYDSWVPGEHSYHSLHNGLETSKDLIEEWTVEVDGGDQVAQLIALQLGYEFGGPVLGFPNTYTFRAYEHYKQRRTPTQHTNALESDSRIKWVEQLFVKSRVKRYPPYDPDREVHRVKRIENPQDTNSSQTGREKRDAFRRTALFNDELWGYQWYLQDTRTNQDLPRLDLNVLPVYQMGINGRGVRVSVLDDGLEYNHTDLRDNYQDTRTNQDLPRLDLNVLPVYQMGINGRGVRVSVLDDGLEYNHTDLRDNYDPEISWDCNDHDPDPYPIQDEQNRNSHGTRCAGEIVMTANNGKCGVGVSFGAKVGGVRMLDGRITDRIEGEAIGKLKLISLVLCCPGTFDRHVEHEMPCADRLAGCQCKNEHSPLTWLVGYAWDKVDIYSASWGPNDDGRTVEGPGRLAVEALKRGVTKGRDGKGCIYVWANGNGGGHSDNCNCDGYSSSIYTISIGSASQQGLFPWYGEICSSTLATAYSSGAYKDQKIATTDINDSCTLKHTGTSAAAPLAAGIIALALQANAGFRFDIRFGFGLLNAASLVKSALNWTTVPDKFICRIETPRLNEADSKITTKKSVNIQIYVENCGVNYIEHVELIVNAEYKRRGALEIYLTSPQGTKVQLLSARPRDTSTAGFVNWPLTSVATWGESPDGVWRATFEDLTNEQNTGKIGPLILVLHGTKDMPTQMRNGPRIYNFGYNNEIPSMFDYFDFDDPSENRVNIDENVLLNIDTDLIIDEIEEELRRNHHSKSFMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCJ9</accession>
    <name>A0A194RCJ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_09354</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCJ9"/>
    <dbReference type="STRING" id="76193.A0A194RCJ9"/>
    <dbReference type="InParanoid" id="A0A194RCJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="265" mass="30546" checksum="095B8B9890A7E375" modified="2016-10-05" version="1">MDNIRKERNEKKIQRNDFVDILLKLEKEKVIEDESILRKDENGVPVKIKLNYNEIHTAAQLFIFFAGGFETSATTMSWTLHQLSYYPDVQRKVQEELDITLQKYNGICYDAIMELSYLKMTIKEAIRTFTPAGYISRECMKKCVIPGTDITIDPGVLINIPAQAIHLDPQNFDNPDEFRPERFTLEEESKRHKYAFLPFGGGPRKCIASRLGLIETMSGLAAILQHFTIYPGPSSKRTFKIKRNAFIIQAVDEDIPILLKPRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD12</accession>
    <name>A0A194RD12_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">Attractin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD12"/>
    <dbReference type="STRING" id="76193.A0A194RD12"/>
    <dbReference type="InParanoid" id="A0A194RD12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin GBD" evidence="4">
        <location>
            <begin position="94"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="339" mass="38289" checksum="4D0C474C65F21282" modified="2016-10-05" version="1">MYARVHEQTAPLCVHPIYRYPLVRKRIHYAELLQEREAQEVREHTCSCNAQAVSCAADTGRCYCSTKGLAGDRCDKCDNTNHYHADVYNKGACYYDLAVDYQFTFNLSKKEDRHLSAINFRNAPVKPDVDADFSITCSAHARMNLTVRTRADPAERTLFSDLNCTNFRYKFAKSEHAFGVEDNVTLTTFFVYVYDFRPPLWIQISFSQYPKLNLQQFFITFSSCFLLLLLVAAALWKIKQKYDIYRRRQRLFVEMEQMASRPFSQVCVELEKGGGGVGVPAPVALEPCRGGRAAVLSLLVRLPTGGTGRAPPLGGLAVASALVTLGHHHAPPAKRPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD37</accession>
    <name>A0A194RD37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD37"/>
    <dbReference type="InParanoid" id="A0A194RD37"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="33" mass="3478" checksum="575E99666EB86505" modified="2016-10-05" version="1">MAVSATAQFPIAAALSAVPPSVGFPWFRPQQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD47</accession>
    <name>A0A194RD47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD47"/>
    <dbReference type="InParanoid" id="A0A194RD47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="45035" checksum="478A7044D5EAD42E" modified="2016-10-05" version="1">MPKRKNEESVESLSKRLKELERYLNIARRIRRSSESSSSSTSSSSTPSSKSEQIISDYQKVEYGWLYTKQMERVKYLNLLGHDDYNRFMNIPDTLLSDFNWWLNALRTPSHRIKVDYFSIEIFSDASTTGWGAACGNQTASGRWSKKECTLHINQLELLAAFFALKIFAKNCHDCQILLRVDNTTAISYINRMGGIQYPHLTKVTKDLWQWCESRKIFVVASYIKSSDNVTADIESRRSHPDIEWEISLDGYQKLIKTFGNPNIDLFASRINKKCDLYVSWNRDPDAYAYDAFTIKWAGFFFYAFPPVAIILKALRKIISEKAEGIMVVPDWPTQPWYPVFMNLVVSKIIRLNPNHIIISNSSNRNIKSSVTLVAGVLSARRCCSAASLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD58</accession>
    <name>A0A194RD58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-aminobutyric acid type B receptor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD58"/>
    <dbReference type="FunCoup" id="A0A194RD58">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD58"/>
    <dbReference type="InParanoid" id="A0A194RD58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15291">
        <property type="entry name" value="7tmC_GABA-B-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002456">
        <property type="entry name" value="GPCR_3_GABA_rcpt_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="623"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="845"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="906"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="930" mass="103935" checksum="F35E58A124F9ED2D" modified="2016-10-05" version="1">MALQTAFDIHVGNNARLRCVRRMQLLLITACLDGEWKMREVYNNDSISSPRTMTRPGSGHAPSTHSMPHYIRNLPFLRLFIGKWICARRGSGVKKSRMLLLLYMGGFNRYSEGRPDNDLHIGGIFPMEGEGGWQGGQACMPAAELALADVNARSDLLSGFKLLLHSNDSKCEPGLGASVMYNLLYNPPQKLLLLAGCSTVCTTVAEAAKMWNLMVLCYGASSPALSDRARFPTLFRTHPSATVHNPTRIKLMQKFGWSRIAILQQAEEVFISTVDDLEAHCKKSGIEIVTRQSFLSDPSDAVRNLRRQDARVIVGLFYVVAARRVLCEVYKHRLYGKSYVWFFIGWYEDNWFETNLEREGIDCTVEQMREAAEGHLTTEALMWNQNANQTTISGMTSEDFRSRLNEALREAGYDIDGERFPEGYQEAPLAYDAVWAVALAFNKTMEKLEKNGLSLKNFTYTNKKIADDIYEAINSTSFLGVSGLVAFSSQGDRIALTQIEQLSNNHYVKLGYYDTQADNLTWLDKEQWVGGKVPPDRTVVVNELRTVSLPLFACMTALCIAGILAAIGLIVFNTMHMHRRVIQWSHPACNTVMLCGCCVCLGAAIALGIDGRWVTPQHYTGLCAARAWLLAIGFSMAYGAMFTKVWRVHRHTTKPKTETKKRVHGWKLYTMVGGLLVVDFVLLTAWQLRDPLQRRVETFPLEAPRHHDDDVHIRPELEHCESEHNTIWLGVMYGYKGLVLVFGLFLAYETRSVKIRQINDSRYVGMSIYNVVVLCLITAPVTLVIASQQDAAFAFVSLAIVFCCFLSMALIFIPKVIEVIRHPTERAESGRGSGSGSTPADEERYRELVKENEELQKLIAQKEERIRVLKQKLAEREAAADVTQGTGGGGGGGGVLADLATATSDYGTSTNYTRSSRASVSDLDFSESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD89</accession>
    <name>A0A194RD89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein gooseberry-neuro</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD89"/>
    <dbReference type="FunCoup" id="A0A194RD89">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD89"/>
    <dbReference type="InParanoid" id="A0A194RD89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="448" mass="49183" checksum="9137EE2D43E0EA09" modified="2016-10-05" version="1">MNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVENRIEELKRQNPGIFSWEIRDKLIKEGICDKNTAPSVSSISRLIRGGKRDESDPRRNHSIDGILGPSSCEDSDTESEPGITLKRKQRRSRTTFSGDQLEALERAFTRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLSAFNTMSLQSAFPSVHQQYEPPSTFNPQCTSWQQSYSSALGSSSVLNSTLAPSLHQSSLTPSVCQSALAASSLHPPTSASFSSGNLTPLSHSSELPTPLQPASDTTPPSTSPITSSPSNQSSGITYQHAYANPSETVSHPYGYGDYSKQEHAMSAHNHWTSRQLSGHPQNKLPDVGAWPENYSSFFGTNASHYATHAHSPTEAKSGYPYLGQLGGMDMGRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE54</accession>
    <name>A0A194RE54_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE54"/>
    <dbReference type="STRING" id="76193.A0A194RE54"/>
    <dbReference type="InParanoid" id="A0A194RE54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="25824" checksum="01D676DA798E5568" modified="2016-10-05" version="1">MFIRGVILTSKFHWTGYKPWWLCYCVGIIVGAAARSSGDYPRDSSLYFQGTSQPQASGTRDDVKDDFVPILNSGMNILEGNNGEENKEIIPILSSGMNVDKQNDKREVNELKVDDHETTNEENNEKWFSTIPSLLDKKIQADAETVSEEEVEDEINVQVNVDTAAEVSTEIRRPQITHRNGKIERRGKLKIVINVKTQKDEPKTFERIKDLFDKEIQAFSRIQVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF05</accession>
    <name>A0A194RF05_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF05"/>
    <dbReference type="FunCoup" id="A0A194RF05">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF05"/>
    <dbReference type="InParanoid" id="A0A194RF05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF103">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="396" mass="45649" checksum="5F8958C753840126" modified="2016-10-05" version="1">MWNSLSEGASRSRAGYLLRGAVDSGAVPNRSCCQTNVVPYLPQCVSVNLDVKFEQGYFKMSYLEKIDGYLDSLRIGKSAMVDSWFMMSSPTPILSVVIAYLLFIRIGPKIMKNRPPLKINKLISYYNAAQVVLATMICMKVFKLNLFRDGIIYAGCRYPANTLNPMLLDLGWWYFFAKFTELLDTVFFVLRKKEKQLTFLHVYHHVIMALYSWSYLKFAAGGEGAVLALLNSAVHVVMYTYYLLSGLGPHFQKYLWWKKYVTTMQLIQFVLMLSYCAWTYFSPRCQYAPGFTYFISANVTIFLILFLNFYVKNYKLQKNRQHKTMTNGHKDKVNSVNNCNEDVIGDICKGIPNLEDIPCKVEKACEEIIKDGKEYLKRRSVNSFVPECDYDSLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGE2</accession>
    <name>A0A194RGE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGE2"/>
    <dbReference type="FunCoup" id="A0A194RGE2">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGE2"/>
    <dbReference type="KEGG" id="pmac:106708722"/>
    <dbReference type="InParanoid" id="A0A194RGE2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="374" mass="41072" checksum="5C8F1CD1B0798AC9" modified="2016-10-05" version="1">MKSIEKDGRELEEIGDTQVDETVAPDTQLNSENMDGDAKKTQIYSSNNRLRHGNAGYLKYVSLVVLTIQNAALGLSMRYARTRDVVMFSSAAAVFMAEIVKLLICILLVMKESGNVKKGFHTMYATVVLNIKDTLRVCVPSFLYVVQNNLLYVSASNLDAATYQVTYQLKLLTTAFFAVIVLKRKLKRWQWCALGLLAGGVALVQLSSAAKETKPTANLQDQSKVIGFSAALAACFISGFAGIYFEKVLKESDISVWMRNVQLSLLSLPFAAITYLIKDPAKDLLKGFDGFVWYLVVLQAAGGLIVAVVVKYADNILKGFATSVAIVISCVASMYIFDFHLTVQFALGTVLVIGSIFLYGYVPKKKEPRTSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH37</accession>
    <name>A0A194RH37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH37"/>
    <dbReference type="InParanoid" id="A0A194RH37"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265191" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1799"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1913"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1803"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1913"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1935"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1953" mass="206119" checksum="2EF4AC0848785B83" modified="2016-10-05" version="1">MKLSCALVLTLTNLVIATPYSFSVKGSGASAKAEAATSPYGQFGVVKPVASKTSGFSGTFSKSSSSSLAPSSASSSSSAYNYNAGQIGTASLGYGSQGFFVPNKNVVPQVVTVPQATAFATAGSNSQTGASVNAQATGSYSSEKGNSFSGNANSPANVQYQSAVPENKPNSYVALSSGIPSHWQEQLKPNSFNTNVPEKPKEAFGVQSFSSDVQSGTAVFSTPSAPSKESALVENAPSYSGGFGGPPGILSPHDKISSVGGNTPGQYTIVSYTPGATVNVPSKQQTLPVSTVNPLYAQHGYQIENTNPTVQSINNEYVFQTENSKPLYKPDIKPTYSDQNKQTASGSYNSASSEWQHDGQHVTLQPHAEIVQTTPKELEQASHSTGQFSSHSEKPLAINNDSKPIKNVQIFIQPIPSNAPQTVSKPVYFTNTQVGSENKKEVKPVYQLSYTGGFGAPAGVLKPSGQTVSSGQTFSSSPVKIEQFESSAEKLTGTKETTLNTDFGGSLNEVKETAQPSSQSTNDHSFDSGSSSATYVTPKPSTSSLFTSSPTEKVSYDYVSTEQKGTDQFTGKPSESSYPNPTVSSWAQNPTVNSLPIRPEFELQKKPTDKTKPTTLSGSFGQVPDDVKPTIQSTINNNGFAYSNKPYKPVVTPTTPYFEATKQKESSFAYSTTQPTPVNSWQQSTYKPSIDGSTPGYFDKQETSPTKYPSLTGYNTVSKQSEQYPSGTYSTVGSTTDDIQVTSNLNQQSSGYGSTVTQEPTAQVSSAGPTLTSFSQEASYKPSFENSLAVSSIPQLSESPKTSSPQTSSTGAFTVSKEVYKVPTQVVSNAVYPPGSVSSVFHLIPNSETSQFHANSHNQHQQSTNYGDATSFVTQKPTKVNFVGQSPGATSGPTSAYFPQQPNKPIVASSLTTSSVSGSYINSDVSPTQKPFFTYNLPKETEVIPSDTSSNIDSTVGTAFEFNSNAYSGKPQTQFNISQQSVEYKPTSFVTQKPTASVNLASQTFSTPAISQSTTFSQQSPKKPSDDKSEGTSPSKNPQYLIYTKPTTETRPQKQSNVYSNAFGTLTGAVKPSSYSSPSSTGYPGWSSNSWSGPSYLTGFNDKPQQTNYLNPNKPTVSSLPEKKEQVIPTNPTEKPSLPVASTTVVQQSSSSITNQKEIEPTATPASGSGTTYSKPTSQPIVSNSEVSYTSFASPKPTKPTNQFSTSNPPVSTFGSSTFSQVKPQYQFSTIQPVTQKKQWYTNNYGTFGAVKPHSYPGFTSSFTTFGQGSVGGLYDKTKQTTQYSSTGQYKPTSTGQYNPSLTGQYNPVSTGQYKPTYNWGIAGQSQFQKPSYQPTQTGGSYVSTYTQTTGKPFVTLSSLDKQKVSGGAPVVNQKVPSISSSFASSTGIAKPTNQPSALYASQKPTSSGTLFESSTGNPSVTNVSDKEKVTSSIVSTTSKYDAQKPVNPTVQTVSNTYVTSSFISAKPTANFQTTGTPLLENKPTYTYTVQQQSVPSEQTVAPTKDVEVGQSIKPVWSYSNQKDSSYTSTTEVATSNLNPTTQSVDGSDNSQFVDKTQASPVRPTSSVNFVGQKPLNPFNGQVGLTNQTPSPGAQNNPSYQQSSEPFSSASSSGSATSQFSQIPSTAYFNSKPDKVQYTFENVQSAYKPTSVAGSITSFANQQNTKPPITAPSQENYSNEAEAGPTKPPGQYWTLNSQSEPQQTTFQTTKPNIKITVVGKPNSNIVSPTYSGGFGGPSGILKPNEFGISSNPGNTQSQFQAASGAYTGAKVDTDSITASYSGGFGASSGLLKPDEKYSIQHVGHNNPSSNGFHAGTSQGGAQTSYVEPTFSASGAYENIKEQTGYGAQVSSEVQGTSVTNVEPSTTTNSEVNSATNAAANGFANNNAYASSSGAVNTGTTFSGQSGRINGFSANAKGSATASATSSGSGGSITTFNRPLSTFTGSPGDIARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMQ1</accession>
    <name>A0A194RMQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuroglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMQ1"/>
    <dbReference type="SMR" id="A0A194RMQ1"/>
    <dbReference type="STRING" id="76193.A0A194RMQ1"/>
    <dbReference type="InParanoid" id="A0A194RMQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF5">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="167" mass="19185" checksum="8A5E1A3F8C7D3662" modified="2016-10-05" version="1">MGIGIPVTKVIHPSSVEALDLQSEVPFTRLRVFRSTGKWLFEENQDLLHMFEKFRQYRTKEEQINSTELAEHANNVMNTLDEGIKGLDDLDNFFAYIHQVGASHRRIPGFKVEYFWKIEAPFLAAVETTLGDRYTPNVENIYKITIKFILETLIEGYEKAGTPGNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMU1</accession>
    <name>A0A194RMU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcineurin subunit B type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMU1"/>
    <dbReference type="FunCoup" id="A0A194RMU1">
        <property type="interactions" value="1738"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMU1"/>
    <dbReference type="InParanoid" id="A0A194RMU1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="162" mass="18559" checksum="AE18911198332F7B" modified="2016-10-05" version="1">MELCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVKGDKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTILFADKDEDGRISFEEFCDVVGNTDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNF8</accession>
    <name>A0A194RNF8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_12460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNF8"/>
    <dbReference type="FunCoup" id="A0A194RNF8">
        <property type="interactions" value="1484"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNF8"/>
    <dbReference type="InParanoid" id="A0A194RNF8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="12">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ18949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="313" mass="34947" checksum="4F57541B17B47422" modified="2016-10-05" version="1">MEEFTSEFVDKIALTCIGVYANIPKIGKPAAEEWNVLSCIVQLDTVTQNYEVVSLGTGSKCIGATKMSPEGIKLNDSHAEVFARRGFMLYIYKNIEKAMMSMSPRETIFIKENGQFRLRDNIEFVFYSSQMPCGDASIIPKSNDSDYGNILTSRKREAEGNNDEIESKILKNDIDDIHRTGAKCLPHNEQDPKGPGAKYHLLGQVRTKPGLGDRTLSVSCSDKIARWIHVGIQGALLDMLLTEPIYIKHFIFGGGVPYSKESLIRAFLNRNGKQQITVPVTPHIYQTTAIFHHIKSEQRPRPAPGSVLLVKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP67</accession>
    <name>A0A194RP67_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anoctamin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP67"/>
    <dbReference type="InParanoid" id="A0A194RP67"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anoctamin dimerisation" evidence="2">
        <location>
            <begin position="163"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="32428" checksum="93978C3B77268300" modified="2016-10-05" version="1">MSDGDPSLEEDVPKPLLERPEENVFTPKISTPIYAGGVKLHHKRSDATETESFLTAAQRNELALQQLFEDGAGDFHSAEKETQEKIVDLQAMSVLSTYQDNLSQDMNTDRDNGSEASTRAAEECGCGEPAQPHLDSSNNNGKPVANHCSIVMGGILNNPSLSFNDGVRSVDFVLVWEAGKENSTTPEAFKQRKVFEENLEKEGLQLEREAPENLHGLHFVKIHAPLSVLKDYSEILKLRMPMKDCSKIRKSGRTNAILNAAMYMSKVCRCRIDRARSLANNALLVNTIAVTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPJ3</accession>
    <name>A0A194RPJ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPJ3"/>
    <dbReference type="FunCoup" id="A0A194RPJ3">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPJ3"/>
    <dbReference type="KEGG" id="pmac:106707686"/>
    <dbReference type="InParanoid" id="A0A194RPJ3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="230"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="417"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="619" mass="70381" checksum="1F1D80A95C8BEF0A" modified="2016-10-05" version="1">MASIEDEWQEDPVTVQMPPPQYSRPQYNNRSRGTRGRYHQNGFNRTRESNSSDQYSSNASGYQSQNSRPQNYNKQRGTRGRYQERSNWRQSEENSNEASGSGQAGPERDTKTKAFTMINEHGVEVIDWDKLNASHDQAQKERWDKLPPIVKNFYEEDPEVSKMSPKQVAEWRRENFDIQVKRTFADRPDLNPIPNPVLTFEHAFKNYPEILDEIYKQGFKKPSPIQSQAWPILLRGDDLIGIAQTGTGKTLAFLLPALIHIEGQVVPREEREGPTVLVLAPTRELAIQIHKEVSKYQYKNVKSVCVYGGGDRKEQIKVVSKGVDIVIATPGRLNDLVLARHLNIINFSYIVLDEADRMLDMGFEPQIRKSLFDVRPDRQTVMTSATWPPGVRRLAESYMKDPIQVTVGSLDLAAVHTVTQKIMFVEENDKEHILMSFIANMGPDDKVIVFCGKKATASHISTELCVKGINCQSLHGDRDQSDREAALEDMVDGTVNILIATDVASRGIDIQDLTHVINFDFPRHIEDYVHRVGRTGRAGKMGTSITFVARSDWAHAKELIKILAEANQEVPDELEMMAKRFEAMKLRREGDDRGRGRGHRGSRGNRGSYGHSDSYVRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPX7</accession>
    <name>A0A194RPX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein held out wings</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPX7"/>
    <dbReference type="STRING" id="76193.A0A194RPX7"/>
    <dbReference type="InParanoid" id="A0A194RPX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAR protein homodimerisation region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="92" mass="10531" checksum="3BF15BC7D93269A5" modified="2016-10-05" version="1">MCDNNSPSTQSIADYLAQLLKDRKQLAAFPNVFMHMERLLDEGTVVIDRFQSYEICTQLDAAQPCFMTGRNQAASDMHVPTPYRRYRTPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPZ2</accession>
    <name>A0A194RPZ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative peroxisomal acyl-coenzyme A oxidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPZ2"/>
    <dbReference type="STRING" id="76193.A0A194RPZ2"/>
    <dbReference type="InParanoid" id="A0A194RPZ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="11">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24401" checksum="BAEC3D6846F9C88A" modified="2016-10-05" version="1">MEAAFNLAKAATIAVRYSAVRRQSQPKPGEPEPQILDYPTQQHKLFICIATAHALQLTGLWLWRTFEAVLADMRKGNTDSLPELHALSSCLKAVSTSDSAALIEQCRFACGGHGYMMSSNLPLLYSFVTATRTYEGDYTVLLLQTARFLVKAWEQAESGKVLTPTVGYLASAAAKEKAVWSDSADGMIRSFQAVKKNISSLRVLPDCDLYLCQISSRSVVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQA9</accession>
    <name>A0A194RQA9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aftiphilin clathrin-binding box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQA9"/>
    <dbReference type="FunCoup" id="A0A194RQA9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQA9"/>
    <dbReference type="KEGG" id="pmac:106721695"/>
    <dbReference type="InParanoid" id="A0A194RQA9"/>
    <dbReference type="OrthoDB" id="5917212at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029205">
        <property type="entry name" value="Clathrin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15045">
        <property type="entry name" value="Clathrin_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aftiphilin clathrin-binding box" evidence="2">
        <location>
            <begin position="396"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113444" checksum="651DF823A400D593" modified="2016-10-05" version="1">MSLPPLVCNTPPPPDQCEDDKDPEDFDINYNLSQDDDEDSNSYDYQTYSNYNMYETDKPENIQDSAWSMNIANNLNSVLTDQVSSVEDNKKTNQTAPIIDDLTEKLTLEDVAVEDLNLVINQEQLNLQVNTSEKSDIDVNGYNYSSEEKVSDEKTITNSDVIETDNVITQNDNVTTEISENSLPVDEHSEAISKTYELPDDEFNNFHSNLDALNNETDIQKQSESELNFENEIETLEEKVPDDDFGDFDEFQFANNDNASTVVENIENPWTNEAPTNDFGDFKANFDDNNDVVQEHMDTSDIANFDKDICVTDEISDDGDDFGDFDDFKSCTKSAVKDELDLQLDQHIPVIDFHSSENENQLLESINNIFSGIFEEEISEPETEFIGRLESVLNETWGHLVDTDVRQPYMVNWNNSLGQKSLLKALCIDSRNILFGPKWNYNMPKYAVNLSAAPLQPQKQSSTLPNMENQNSDKSLNKENDNWVDPFSSNGQESCNNGENDVAATETNTTDLEVFEKVMSVKLDKVYPSSLNVQPLRQISLPDTHIFTPSDSETPRSKTIHYDTVAPVLISQPVTDVSTPSTVILSDEVPKLDGDNDYWEFQDFKSTTENIQPPKDVNKSDIEPDKSSVVNSNNLIPNVGGTYQPQLLQPIKLEPLVPTLNWPDPGEVKETFDDFSDFVSSAPWESDKNNTSIVQENKSEEKPIVSNKQNDTSIIETNSNVEGNDDEFETFQSAPTVPQSIHSKPFEDNHSQITYQLSSSKTADFDNAFSDFGKINKNEITKPHGVLAKNVPHFSTENYSNSMSSVRDGFGNNSLIHSVETPNMLQPVQASTSSASRQNNTAQILQPLSLESYSQINWPNPGIDLQDLSRFNPVETVPSLKSDISSNSQSKVNSPSHTDKNSGRNEVLDDDIWGEFVSSKPKQQTSAKKPPIFGDEDEWTEFVSSTSVKPQNGLNTISLNVHTNLSLQKSSNLNKLNVKNNQISLDIPTLNYITPKSSRKTYNDKHFQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAK5</accession>
    <name>A0A0N0PAK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAK5"/>
    <dbReference type="STRING" id="76193.A0A0N0PAK5"/>
    <dbReference type="KEGG" id="pmac:106719319"/>
    <dbReference type="InParanoid" id="A0A0N0PAK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="416" mass="46808" checksum="3B2B20D2DF60FEC2" modified="2015-12-09" version="1">MRRHESSEEILRSVKSGNFWRNSTKPDIIPSSSVQDVSTLDNLSRVRRSRRSRPASYGFPEISITDKSDKKTLRRKYHTLKSLVYTEPVESIKELKRRPRSAGSTVRNKEALSRPSLLETLDFINGVKDALYEESGTSEAEDCGWSYEEELLLSGRSPANLLAGLSAPELLHLALGDLVSGLLQRGKFTILQELCSYLGSSGEGALFALHRLARAARSRSSERATNNWKLPESVDDASQSVQTYRRRSPDDVSGDEAHAQPPQPPPLPRNLNKTNKIPNHYPDYISAKRLQDLENHLNYLEQVKSRLTLQQNLNYPQNCTGIINPIYDIKMPKDKFAVKRTKSLGRTFSSRHLGLEITRYNLTLGPKSGKKTNDVVTAMNGTSGETGLDLRSHFFQRYSTENVVGDSYRVSRVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB39</accession>
    <name>A0A0N0PB39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative odorant-binding protein A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF11">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857328" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12246" checksum="B3CB0774F2B87DDD" modified="2015-12-09" version="1">MQVSYIVIALCALVATCLAQAQTDRPAVSDTALEEALNDKRFIQRQLKCALGEAPCDPIGKRLKTLAPLVLRGACPQCTPQETKQIQRTLSYVQRNFPQQWAKIVRQYSG</sequence>
</entry>
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    <accession>A0A0N0PB68</accession>
    <name>A0A0N0PB68_PAPMA</name>
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        <submittedName>
            <fullName evidence="10">Putative G-protein coupled receptor 52</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">RR48_05858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to hormone stimulus"/>
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            <end position="57"/>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="340" mass="37551" checksum="48311A79DDDAA87C" modified="2015-12-09" version="1">MPARLGGAGAGAAAADVSVADSPLAAFESLTQAAVIAVVGIAIVISNLLIIAAFLNFKGVCAGLAHEVINYYLLSLAVADLLCGLLVVPLSVHAAAVGRWVFGGLVCRLAGYLEVTLWSVSVYTFMWISVDRYLAVRKPLRYETVQTRTRSQCWMVFTWISAAMLCCPPLLGYKKEANYDARTFICMLDWASTYAYTATLGILVLGPSLISIVYNYYYIFAMRRKLNSGAPIHDKEYATALAENLANPSHCMSFLLVAAFWLSWIPYFALQIYEYFTAQVKVPMLHFGVVWLGILNSFWKIVILITFSPQFRLALRILCLTCCRAKGRLQAELVGMDNDD</sequence>
</entry>
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    <accession>A0A0N0PBQ0</accession>
    <name>A0A0N0PBQ0_PAPMA</name>
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            <fullName evidence="4">Protein canopy-1</fullName>
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        <name evidence="4" type="ORF">RR48_04587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Ditrysia</taxon>
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            <taxon>Papilio</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
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    <dbReference type="EMBL" id="KQ460940">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CNPY"/>
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        <property type="entry name" value="DUF3456"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11938">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3456" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="208" mass="23663" checksum="544D38B0FC0DA45A" modified="2015-12-09" version="1">MDAEGNTMQQKVPAHRSAVYISELIDSICKKMDDYVRVYYKSTGKLAIMQLMTEEGGMNPEFSKTKFVTDDDLNKSLEYYCERMFEDSEDEITSLYQRRPHDDIMPDAEHAICFNHTKYCEPWMLPTSEDTTWTPEMEAEYVKIHGPDPYGFGGAPPPPASPHMPDLADLPDLGELPDQETEPDHDLGEDELEAEAEAEAEADSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD43</accession>
    <name>A0A0N0PD43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating transcription factor 7-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD43"/>
    <dbReference type="FunCoup" id="A0A0N0PD43">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD43"/>
    <dbReference type="InParanoid" id="A0A0N0PD43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating transcription factor 7-interacting protein Fn3" evidence="2">
        <location>
            <begin position="850"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="956" mass="106227" checksum="7B41786C6271C2EE" modified="2015-12-09" version="1">MALHDTTRFCVDYIRLFTPARAASLRFVFNKSNIRDVITKYHTMQLTVDTGAPIDIEFKMSSIKEVIISNGNETFSDDIKNSSDIVKDNTCDTAENNHKLQNLQCNDKIAHKDDTASSVESEEIVKSTSEETSIDDFESKSHSPKSSTNEESKPEDIVNNDNPISQDQESESQYELSNHNSDEEENVMETDVTEKIDNVESEQQSNVIVPKPGVINQINGGENINTQDHENTTNDSKIYNKITLKGNEIIEQNEGEQTNNDIKNMDSESSIPDSVIDQVPNKGDEKKEQSLEDVTESKSENTDSLISPKIDNDDCKVIESESATDSTLQKSPKPDNSTKESEITPESVASAETDTKSSKIEKEVEKINENKTHNGKDNNDEVEDKLIEEKKESSLISKLTNILDLLSDDEEERHGDTSTNETSKVDKQCISLVDDDDVMLIDEETSVKEDAKTTSIQTDEVIPETCDENAALSQVKKDEVIDEKQETGSEEVVYNLDNNKLDSQTNNVKEISSSKPLLSLNFLNSCKKTLSDMTREDLEDFCSMKILESVLDRSNLGDLKVQLKTMAATIEEFKKKTNLLSKQNRDLQVVLKSVQEEQKKSSGTAVTPLKITRSVGMQVLMTDKSNAKRKNLQMNNSSVLPTQPSHVDKTNRNSSIQKLHKTKNQPIPVPRLVPAANTNNKTSPAAISNIADPGKSPQVPPLVNGVRNSPPVLKPEKRSRVQSVTVDLTDDEPPLKLTAKISPAPGVRLVPAQNLLPPQRPQFTPAMTSPRKVYIPISGPQSQNVRPGQAVVLKTVPPSPGLRPRMPANNNVNKVQPNTIRMNRPVSAGRHPAPLPDVVKQYQPTSWKALPPAPDLKLSKVENGIVISWKIDGYQEDSYEEITSYQLFAYQETNCPPSTALWKKIGDVKALPLPMACTLTQFLAGFKYYFAVRAIDIKSRFGPFSLPASILLLNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDW8</accession>
    <name>A0A0N0PDW8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Eyes absent homolog</fullName>
            <ecNumber evidence="14">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="14"/>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDW8"/>
    <dbReference type="FunCoup" id="A0A0N0PDW8">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDW8"/>
    <dbReference type="KEGG" id="pmac:106721188"/>
    <dbReference type="InParanoid" id="A0A0N0PDW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ18458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="565" mass="60653" checksum="6ABFA84CEB3094A9" modified="2015-12-09" version="1">MVTLMPCNYLGGTSPRCSLDHNEPKAKRPRPDTGTDVRLSGDNNTSPCASESTSESPPSLLQDATLPALLVTGASTLFQATTSNSSALSLTDSLSLPQEDCSLANGCTNALSGLALPLTSTGLCSTTSSSAVAWLMNDDSTGGGVKSEVRSPGLCEADAALYGETLPYDQSALPYQYYNSMQQYGGGGAASSYVSSTLYNQPYAAYPPPHNTNNRSSCKATPTYLSAYSMGGVGTVPSSGFATQPSPYAYSSYNGGLAQSFPNAQQDYSSYASGYADHNVAQYGGYYATPSYSPYVSSPSSSGSAGHTSYLIGGGLAGRIYRQKFMDTQHIVQLGFRIEEMIFSLADAHFFFNDVEDCDQEHIDAVAADDSGQDLSTYNFAADGFHATTPGLCAPGMRGGVDWMRKLAFRYRKIKDTYNNYRNSVGGLLGPAKREQWLQLRAELEQATDNWLTLACKCLNMINSRENCVNVLVTTTQLVPALAKVLLFGLGGVFPIENIYSATKTGKENCFDKIKQRFGERCTYVVIGDGKDEEAAAKNKNYPFWRISGHSDIAALYNALDMGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEE7</accession>
    <name>A0A0N0PEE7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459805">
        <property type="protein sequence ID" value="KPJ19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="51"/>
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    <dbReference type="InParanoid" id="A0A0N0PEE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1A"/>
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        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857415" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="39"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="163"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="437" mass="47852" checksum="0F4624FEA43FB1A4" modified="2015-12-09" version="1">MGDSIDDLQICEPARRIDQFEQMLRLLVSICLLTLCGAQDGSGDLDAVIKQIFGEPTTAKSIQPSTLVPGIVKPVDKSCKMDDGRVGECVRYYLCNSNNSVITDGIGIIDIRVRDGPCADYMDTCCLTPDTRNENNPITPPPDTQPQRQGCGWRNPDGVGFRITGDKDGESKFGEFPWTVAVLNSDYIDPRIEPVNENEPDGQKLNVYVGGGSLIHPSVVLTAAHYVAGAKALRARAGEWDTQTTKEIYPYQDRDVAKIEVHKDFNKGNLFYDIALLFLSTPLDLAPNVGVACLPPPRERVPAGTRCFATGWGKDKFGKEGRYQVILKKVEVPVVARDVCQEKLRATRLGHFFELHTSFMCAGGEPGKDTCKGDGGAPLSCPIQYETDRYMQSGIVAWGVGCGEDGTPGVYVDVSNLRNWIDDKIAGMGYDPKVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEQ1</accession>
    <name>A0A0N0PEQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ecdysone-induced protein 74EF isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PEQ1"/>
    <dbReference type="InParanoid" id="A0A0N0PEQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Ecdysone-induced protein 74EF isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ets_dom"/>
    </dbReference>
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        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="299" mass="33232" checksum="2896146DFE6F7922" modified="2015-12-09" version="1">MVTLAGVLSKEAGSRGRAGGAGDLRALMQCRRVIDHARGAAQRKLLQAPSRPVAPASPSVYRPPRAPSPLHAIPYLGLSLRTSVDTYVPAYMKVIRVIRSLVPPPSTISSILIGIIQQPMGAVNEREAYGYGYGGGGAGGGGHHFAAPAPPPLAHEELPYSVFDFGDYQRHHHHNKLKPKKRPRSDVPPAPGVKRKSREGSTTYLWEFLLKLLQDREYCPRYIKWTNREKGVFKLVDSKAVSRLWGLHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDIVEIDCSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PET0</accession>
    <name>A0A0N0PET0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific lipid-transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459829">
        <property type="protein sequence ID" value="KPJ19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PET0"/>
    <dbReference type="STRING" id="76193.A0A0N0PET0"/>
    <dbReference type="KEGG" id="pmac:106713393"/>
    <dbReference type="InParanoid" id="A0A0N0PET0"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="423" mass="45181" checksum="96F88FAA429ABF05" modified="2015-12-09" version="1">MCSKVYAVGVGMTEFVKPNSLRDYPEFGKEAVEKALTDAGVTYDVIEQAVCGYVYGNSACGQRVLYQVGMTGVPVHNVNNHGATGGTALHFAHRLVQAGAHVVLALGFEKMTAGALPATAYPDRTYPADIHIKKMLEIVKLEKAPIAAQCFGNAAKEHMEKYGTTEAQFAKIAVKNHRNGSANPYALNRNVYTLEEILNSKRVFGPLTKLQCCANCDGAAAVVLMSEQAVARHNLASKAVEIVGIALATDTNAVFTDTTRLRIAGYDMTALAADQVYKTTGVSPREVDVVELHDCFSSNELITYEALRLCEEGKGGAFVDAGLNTYGGQVVVNPSGGLLAKGNPIGATGLAQCAELVWQLRGEAGARQVSNARIGLQHNLGLGGAVVVAIYRKGFDNKNQRDFPSSHQKFKMAAKDGKIRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF97</accession>
    <name>A0A0N0PF97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cryptochrome-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01011472">
        <property type="protein sequence ID" value="KPJ20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF97"/>
    <dbReference type="STRING" id="76193.A0A0N0PF97"/>
    <dbReference type="InParanoid" id="A0A0N0PF97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857471" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="112" mass="13208" checksum="6028D900C4BBE55D" modified="2015-12-09" version="1">MSLWVCLTFAGISKLCFEQDCEPVWRARDDAVKSTCRETGVVCREHVSHTLWEPDTVIRYNGGIPPLTYQMFLVSLCFYWRNTYTKIYCRHLSSPCLYPTLRYEVFQLRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I504</accession>
    <name>A0A0N1I504_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone deacetylase</fullName>
            <ecNumber evidence="15">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_03495</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="15"/>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I504"/>
    <dbReference type="FunCoup" id="A0A0N1I504">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I504"/>
    <dbReference type="InParanoid" id="A0A0N1I504"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000004">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="20">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="20">
        <location>
            <begin position="155"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="501" mass="57220" checksum="6E91A8CA0DA8E9E8" modified="2015-12-09" version="1">MSQSRVAYFYNADVGNFHYGPGHPMKPHRLAVTHSLVLHYGLHKKMQIYKPYQANAHDMCRFHSEDYIEFLQNVTPQNIQTYSKDLLHYNVGDDCPVFEGLFDFCSMYTGASLEGAMKLNNNVCDIAINWSGGLHHAKKFEPSAYSKDLLHYNVGDDCPVFEGLFDFCSMYTGASLEGAMKLNNNVCDIAINWSGGLHHAKKFEPSGFCYVNDIVIAILELLKHHPRVLYIDIDVHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEIGAESGRYFSVNVPLKEGIDDQSYVQVFKPVISNVMEFYRPTAIVLQCGADSLAGDRLGCFSLSTRGHGECVKFVKNLNVPTLVVGGGGYTLRNVARCWTYETSLLVDENISNELPYTEYLEFFAPDFQLHPEITRGHLICNQQVLGSNPDMYQCAFRFSIYICTLSDVLTMKEKRRDFFPEDYKIKEEPDPDVKMTQEEIDKFVEPKNEFYEDDKDNEKETVIEKKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I629</accession>
    <name>A0A0N1I629_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GDNF family receptor alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460891">
        <property type="protein sequence ID" value="KPJ10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I629"/>
    <dbReference type="STRING" id="76193.A0A0N1I629"/>
    <dbReference type="InParanoid" id="A0A0N1I629"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057681">
        <property type="entry name" value="DUF7921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059035">
        <property type="entry name" value="Fn1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25537">
        <property type="entry name" value="DUF7921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25868">
        <property type="entry name" value="Fn1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="770" mass="85855" checksum="583F83B32651BAC7" modified="2015-12-09" version="1">MGAIAVKLMSDGWHANRNATRVTSWIGGMSITQDGNLITPDKIMTHVHRYASPHYHPHGHHSHRWNHEPGGSEDPLNATKTVYGPGYIDDNLQHNTINTDITNTKQPPTERIGKENGKSGDEKVALQSTCHVALDTCIKDSECVASLTPVLQKCHSTDCDREGCMTALRGFYRKPSVAWNTEIAFCLCKKTDNREDSCMNAQERLHPSCAQRPPVGSPLPACHTLAHNCREDPECRIRLENYEQWCAVDAVTQGCAGSPGACRAAVVAVLGTQLRAACACRGTDFAQLYDCLGWQRLLWLNPCVVESQHDYHVKTYGSLLTTTPFDNGIRYMTVPPAPAGPRTTHHHRHTTQHAQERSQENREVLSPMTTMTEQTAVPNEVGQISEPIVETTTETTTVATTTTTTTTTTTTTTTTTPKPTTTLEPTKYCIVKKPESDDQAQYIKMGETRRLYRSAELAECTDLCVCETSLQVSCKVACVPRAPCSSRLAHYSHAAPAYQAYRGRCYCYSGSFICMRPNPGEYKLPEGVYLLLGFSAVDEALLRPHTGLGAEDAVRLLQHYLHYLHPEDSNCTLTLFNISNENVIISASVPPRQQEILREAGEDLLDKEKEACIDVLKIVKSRINSQHEDISSHLLLSIFKIAEVDVVYPAPPSSSTIMNKPQTYIYMFITLIVSIQNYKQTIIFFTVIFNLFNFLSKNSKNVVPLNINVINVLGKNEFIVNILDIVKMHNALALDNAQHTIRYIKDIYVNNETKHIKAVTYNFNINVVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6Q9</accession>
    <name>A0A0N1I6Q9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inactivation-no-after-potential D protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460731">
        <property type="protein sequence ID" value="KPJ12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6Q9"/>
    <dbReference type="STRING" id="76193.A0A0N1I6Q9"/>
    <dbReference type="InParanoid" id="A0A0N1I6Q9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23064">
        <property type="entry name" value="PDZ3_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF89">
        <property type="entry name" value="INACTIVATION-NO-AFTER-POTENTIAL D PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="286"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="372" mass="39669" checksum="607476937AFE1201" modified="2015-12-09" version="1">MNEVPTRPSDSELLYKPVVLFRKIWQRTLSFRKRKSEDRFAGYKGVRDITIKKGPAGLGIMIIEGRHTEAGRGIFVSDLQEGSAAEQAGLNIGDMILAVNRDSLLSCSYDAAAAKLKHTEGVVILTVCSPNMKDPDKEDPSGTSGASGNQTPDALSAGASRPQTPRPAPSPAKPEPPPDPATAQVKPNHEMVIEINSNNENLGVVLLGGSDTLINGAAAVILDIYKTGAIGKDGRLQVGDQIRECNGIAITNKMAHERVCLSIKLKAPKLKLTVFRPDPIQYEEVEVDLTKKSGRVLGLTCVTPVQGTGVYIGDLLPGSPAEVDGRIQKGDLLVSVDGKDLSGADYIAAATALKLCANKTTIKVKRFKIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8R7</accession>
    <name>A0A0N1I8R7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8R7"/>
    <dbReference type="InParanoid" id="A0A0N1I8R7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="210" mass="24037" checksum="84EB48204BC92DD9" modified="2015-12-09" version="1">MSSMWGWCWLQNVDLDGDVPLTQKIRECVQIEPNAGDCILGVTETIFSNDDSNEPIIKHKQSKSKKETSDKVKPNAGDCILGVTETIFSNDDSNEPIIKHKQSKSKKETSDKVKNKSSENNRNSRHLKSPEDNRRTTRRSISSPTNILTLRNRNSKDQKNIDEHMKKSSEPLKSILKKEKIKEEDILVTPKSKRGRERESRSNLPVKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9D7</accession>
    <name>A0A0N1I9D7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_03026</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9D7"/>
    <dbReference type="FunCoup" id="A0A0N1I9D7">
        <property type="interactions" value="1774"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I9D7"/>
    <dbReference type="KEGG" id="pmac:106712068"/>
    <dbReference type="InParanoid" id="A0A0N1I9D7"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="127"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="402"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="519"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="633"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ13930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="773" mass="86641" checksum="AB235355DF21BAD5" modified="2015-12-09" version="1">MATYEEFIQQNEDRDGIRFTWNVWPSSRIETTRLVVPLACLYQPLKERPDLPPIQYEPVLCTRNTCRAILNPMCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPNFSTIEYTITRAQSMPPIFLLVVDTCLDEEELGALQDSLQTSLSLMPQNALVGLITFGRMVQIHELGTEGISKCYVFKGTKDLTAKQIQEQLAIGRVNAPNPQGRPGAPAPMPPAHRFLQPVKQCDMALTDLLGELGRDPWPLGVGKRPLRSSGVALSLAVGLLEVTYPNTGARIMLFLGGPCSQGPGQVVNDELKQPIRSHHDIHKDNAKYMKKAIKHYEALSLRAATNGHSIDIYSCALDQTGLMEMKQCCNSTGGHMVMGDSFNSSLFKQTFQRVFAKDQKGEYKMAFNGSLEVKCSRELKITGAIGSCVSLNVKGPCVSDQEVGMGNTCQWKMCTFTPSTTMAIFFEVVSQQAAPVPAGGRGCVQIITQYQHSSGQRRVRVTTVARNWGDAAVNLHHIAAGFDQEAAAVVMARLVVYRAELEDGPDVLRWLDRMLIRLCQKFGEYGKDDPNSFRLSENFSLYPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFGGPPEPVLLDTSSIQPDRILLMDTFFQILIYHGETIAQWRALRYQDMPEYESFAQLLRAPVDDAQEILQSRFPVPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGGAMPIPSADGGAPVLTDDVSLQVFMEHLKKLAVSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBN6</accession>
    <name>A0A0N1IBN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin domain-containing cysteine-rich protein CG31559</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBN6"/>
    <dbReference type="STRING" id="76193.A0A0N1IBN6"/>
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            <end position="223"/>
        </location>
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            <end position="302"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="393"/>
        </location>
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        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
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            <end position="299"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="368"/>
        </location>
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        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ08005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="501" mass="55194" checksum="991AF94030C3B545" modified="2015-12-09" version="1">MMEEVTTRPSLEYIPSLPQKVKQRGSTTFTQITSEDAPLRVNAYSASDGRSNMDSLSSMHSLVLNSKSPSATVFIAATQPERPANTAGSDALSGAGPHVVTIRINTDADKPKAPKISSVHLKSDVDFETYKISDNKKNNSLVRLNVDDNQPKILDSEEQTKMDKAPYIYCNSFINSNNTIMSSGQCSPSDTLDSGTCSDLDGTPPPLPKKKTSKSSSKKAVSVTMISSARNISELDFEDNDSNISCDSLNSSEFNGSMHADEGHGDDTGKKEKKQTPEPPSAPLLPTFINKANNKNGSFLPQGLLQDIRDHSAKLNTVETESDSSDQTQEEASRNINENANVSKESAQLTSFRLVSQLNESRNNSGAESSPAHFENKTPLIKETTYEDRKKEEKMKQERICYSSHYFDTDKFYDFHLNEKQFDDVPVKSASVDKSVSEETSEQEYFAGVKDYKSEEPTSTIRSSKGTIRGVKNRVRAGIATFLQMQSATKVICTIFFIISQ</sequence>
</entry>
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    <accession>A0A0N1IG95</accession>
    <name>A0A0N1IG95_PAPMA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">RR48_03695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Ditrysia</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14335" checksum="2A7FFAAF29B67818" modified="2015-12-09" version="1">MDSETKVEDKVDTVSVYNYDDAVELTGHGRYNYLVLFTCCIIHHAVALDMFGFSMVLAAATCDLQIGIKETGILASAPFAGVFFAFPFGYYADTGGRKRALLLSTIVGFTFAALSSFSINWEMMLAFKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH71</accession>
    <name>A0A0N1IH71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor 1</fullName>
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    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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            <taxon>Ditrysia</taxon>
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            <taxon>Papilio</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A0N1IH71">
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IH71"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="16385" checksum="CEFAEB753A4E9629" modified="2015-12-09" version="1">MDDLEKKIPVLCVGPKGSGKTTLLKKLQEAEGIDYTYSPVPTIGTNIYDINYVNKQGKKQVLSIREIGGEMVTLWNNYLEGVEKFILVLSKMDAAYRQMRNEALLMLQHSRLCSELANAPALLEASPLTNIGIDALRAFLGDARKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHQ8</accession>
    <name>A0A0N1IHQ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHQ8"/>
    <dbReference type="InParanoid" id="A0A0N1IHQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10770" checksum="6BD1AB4F1BBED209" modified="2015-12-09" version="1">MYRSRAPPLILTPLTPLTPLTRSQALNTSAGARNTPHTTRTARHAPHDTPHTTRPTRHAPHDTPHTTRPARHAPHDTPHTHSYLDNVFVECDNRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHV2</accession>
    <name>A0A0N1IHV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHV2"/>
    <dbReference type="FunCoup" id="A0A0N1IHV2">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IHV2"/>
    <dbReference type="InParanoid" id="A0A0N1IHV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035159">
        <property type="term" value="P:regulation of tube length, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF4">
        <property type="entry name" value="LD42595P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="23365" checksum="5AF226B881FE3262" modified="2015-12-09" version="1">MYGRKTPSTYRSTPSVYSHYTGRSSTNLRSSKSVKSLRLPWYMKPILHDAFLLDLQRGSLLTGFVSIFIALFTFAQSIFDLYCLGMAAPGAVHYGYYEYEKKIVPWLYTFGVFILFRTVAFIFAAIVNDMIFSYNVLMCLCWVVFCVVGVYGWLLVYSLYLELADLTKLEDLAHLRMGTMASLNASLAGSRPTTPHSTVSTMPASQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHY8</accession>
    <name>A0A0N1IHY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01027713">
        <property type="protein sequence ID" value="KPJ21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHY8"/>
    <dbReference type="STRING" id="76193.A0A0N1IHY8"/>
    <dbReference type="InParanoid" id="A0A0N1IHY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="12967" checksum="2BC346CB717A30C0" modified="2015-12-09" version="1">MFNSTKIDDLQISSQLICVKQISELAHSSAQLTCIESLFAFLAVICESINSSRLVGSHRDELRKGRQRMCAEGATKILEACKDIVNGQVDLTTWEKKIAEESKIEFDEDDETEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIH0</accession>
    <name>A0A0N1IIH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460246">
        <property type="protein sequence ID" value="KPJ16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIH0"/>
    <dbReference type="STRING" id="76193.A0A0N1IIH0"/>
    <dbReference type="KEGG" id="pmac:106709396"/>
    <dbReference type="InParanoid" id="A0A0N1IIH0"/>
    <dbReference type="OMA" id="EFMRMIK"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="20804" checksum="8552CBB1B63EF820" modified="2015-12-09" version="1">MTTEQPKVEPEDEETEQEIKEKSVSARLIFTEQQKRDLRDAFNLLDHTGEGKIKADDFRVAIKALGYEPTKEELQHMINRVDKNQTGKLSFENFETAIMRKIMSLDSDGDIMKSFRLFDDGDCGFISFENVKRVSEILGFGLTDEEIEEIMDDADKDFDGFISVQEFMRMIKTSVRIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJ66</accession>
    <name>A0A0N1IJ66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chorion class B protein PC10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chorion protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJ66"/>
    <dbReference type="KEGG" id="pmac:106721216"/>
    <dbReference type="InParanoid" id="A0A0N1IJ66"/>
    <dbReference type="OrthoDB" id="10436085at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873994" evidence="4">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="15978" checksum="E40EE4C63489A45B" modified="2015-12-09" version="1">MASVLAALCVFGCLVSSLRGQYLPLNAQQYGVGAWGVRGVDAGCGCGALLTDNAASALAAADGGGFAVVSSSPTPPHGVSVVSDNEYSGIVAVVGQLPFLGTTYLEGAVPSAGAGAVAYGCGYGDVAILSEDFAGTTALPGSNGINFGRGYNELRGCGCGLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INL2</accession>
    <name>A0A0N1INL2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INL2"/>
    <dbReference type="STRING" id="76193.A0A0N1INL2"/>
    <dbReference type="InParanoid" id="A0A0N1INL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="7">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="7">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="8">
        <location>
            <begin position="306"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="42473" checksum="603635E86D1A8DB3" modified="2015-12-09" version="1">MKPYSVNFNDILDKPCAARQIKDRSIICVCNTTYCDEFTREKPVKGSYVTYTSSEAGSRFKKGYGVFHDSGWNPKCCSASLVVNSKVKYQVAEGFGGAVTDAASINWKSLPEVMQQSLIDALYLHACSARDLLHKLRPLLHPAHSSPADKEFVHLVLPSSYYSSKGLEYNMIRVPIGGCDFSTHAYAYNELPENDIDLLNFNLTSEDFEFKPTSKRRRGSFPWQKLKVDLGSWPRAVTYISDILEDLNHNVVGWIDWNLCLNTHGGPNWSENYVDSPIIVDVIKNEFYKQPMFYAMGHFSKFIKRGSRRIEVNEIKRLFSSSVKHVGFLTPDGTVVLVLLNEGEKRIVSVRCGKKKAVLELEAKSVTTMEFYCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INZ7</accession>
    <name>A0A0N1INZ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INZ7"/>
    <dbReference type="FunCoup" id="A0A0N1INZ7">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1INZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF111">
        <property type="entry name" value="CHASKI, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="506"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="716" mass="80180" checksum="1432CA5505D4F5F7" modified="2015-12-09" version="1">MVDRVTFEGLEDVDSIYSDDVNNKKLPPIPDGGWGWVVVVAAFLISACADGLAFSFGLLHEEFTSYFETTQSKTSLIGSLFIATPLLAGPIMSALVDRYGCRTMTMIAGLLSTIGFLLASISNSVEMLCLTFGFLSGLAMGILYVTAVVAVAFWFDKRRNLAVSLASCGIGFGTLIYSPLTHYLLELYDWRNTVVLLAGTLLNMCVCGALMRDPEWLTIKQERARRLSKPRSGRSPSVGSMSSRSIGGESLFLTPEEIKDLLKSGQSPDYILATLTTSIAEAQKLEETTQFNAEQAYKRIHSDIHLPTFIAQNEKVPVEVIEKLMSNKRLYNIILQNYPDLITRRRSEENLYIEGSELVKNEPAQLPVSVTIKMPNKYESETNKEEKNTERKEKLKNQNSIDKDAKINTNTDNNIDKKTKPKVPVQQTNWLSRQISMDHHYLRDMPLYRNTIMHRGAMMNIPRYKLRASSLPDIYRNSMWSLGSASDDGMKWYHRLWQTTKSTFDFRMFTEFHFLMFNLSSLILSVWFIVPYFFLKSYMTSRSTTGGAEMISIIGIASSIGIVALGWAGDQPWINVTKTYAVCLIICGLSVGLYPLFITNYWALAIISAIFGLSFASSYSYTPAILMELMPIDHFTVAYGLILLSQGIGHLVGPPIGGMLMPPTGSWDLTFYAAGLWLIISGLFVGVIPYTRDMRMCGTAPLFKEAEEARKENVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP83</accession>
    <name>A0A0N1IP83_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CUSTOS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460655">
        <property type="protein sequence ID" value="KPJ12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP83"/>
    <dbReference type="STRING" id="76193.A0A0N1IP83"/>
    <dbReference type="KEGG" id="pmac:106713038"/>
    <dbReference type="InParanoid" id="A0A0N1IP83"/>
    <dbReference type="OrthoDB" id="8196889at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22186" checksum="0EB96D99390AA654" modified="2015-12-09" version="1">MSDSSSEEDLSRFQEVVDNSFIKSVNTSTRIGTTSSYGDQKLRSERYLEEAGHYNDVKVSNELQKRIAAKVSEIINRNLIFIDVEPPKMKRETFVGGVKLFKDSKDLLSCEDVRDTATERHNELARNIRKRKCLIDEEALDERDKIKSAAVSGEQVLSQDDTKYWKSRRREKIFKYRRSMSHSNVLIAAECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPE6</accession>
    <name>A0A0N1IPE6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell death regulator Aven</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPE6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPE6"/>
    <dbReference type="KEGG" id="pmac:106711973"/>
    <dbReference type="InParanoid" id="A0A0N1IPE6"/>
    <dbReference type="OrthoDB" id="6338233at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44710" checksum="9BE838113D277595" modified="2015-12-09" version="1">MPEDKKSNRKNDPKEQRRSRRRNDQQVEKKENKQPATKGQPVPVQKESEPAKAPGPDKPAYEPPGPEFYKNLKRETEEILKITEEANSKYKKKEIQSNWAKYEMPIESYNEIEEQENMGADYEALIQAPLSVGGHFQFKHEKSWDITTGPSLYDKYFEIDMDNLAIALSTIPFYERNSIDQSLFSETDILNMNNRATKFKQKYYNDKSYTTPEMEAQERILQKLRESDEKESSMSEEKVEMTPKDVDFTNLENKNETDNQKITTKEKTSSPSPKFNELTKIETQPETLDTKEMEYDKPFVKVEEKVNIKQKSVDNKHADDIDEIIAVIDNKKVESPVRSNPKTSVNTAAVKVVENISPIKEQAPPKNPVIESPEDLEKWLDDFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPL8</accession>
    <name>A0A0N1IPL8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPL8"/>
    <dbReference type="STRING" id="76193.A0A0N1IPL8"/>
    <dbReference type="InParanoid" id="A0A0N1IPL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="132"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="502" mass="56762" checksum="BCC01B7118BCC988" modified="2015-12-09" version="1">MEQVEDLFDCFEESAEDTAEIELPKGVLRESKEPKNSSNKRSHEQVEYADTTETKRPKQDDDEEEDEADLLADLDLDVLKSRIVIHTLETSDGCTHEVAIPPGHEYVPLAPISAEPAKQYSFILDPFQKEALLCIDNLQSVLVSAHTSAGKTVVAEYAIALSLKNKQRVIYTTPIKALSNQKYREFSEEFQDVGLITGDVTINSSASCLIMTTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVHYVFLSATIPNARQFAEWVCRLHSQPCHVVYTEYRPTPLQHYIFPAGGDGIHLVVDEKGQFKEDNFNTAMAVLSNAGDAGKGEQRSRRGGVMRGNNKANIFNIVKMVMERNFAPVIIFSFSKKDCEAYAMLMAKLDFNTIEEKKLVDEVFNNAMDILSEEDRKLPQVEHVVPLLRRGIGIHHGGLLPILKETIEILFSLGLIKALFATETFAMGLNMPARTVVFTNCQKFDGKDFRFVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPN4</accession>
    <name>A0A0N1IPN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPN4"/>
    <dbReference type="InParanoid" id="A0A0N1IPN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8012" checksum="004E85F5A6CA1B95" modified="2015-12-09" version="1">MSAKSQRKCVGCKNAKGTKAKQLLIKERNRVGARLATLDQSLLALRDSGRQQAQQLRRATAALHDIDNALRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ97</accession>
    <name>A0A0N1IQ97_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="4">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02053</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KQ459680">
        <property type="protein sequence ID" value="KPJ20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ97"/>
    <dbReference type="FunCoup" id="A0A0N1IQ97">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ97"/>
    <dbReference type="InParanoid" id="A0A0N1IQ97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03706">
        <property type="entry name" value="mtEFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="506" mass="56116" checksum="839B0B6226C522A6" modified="2015-12-09" version="1">MELNKYCTKAKVKTKEKKHCNIGTIGHVDHGKTTLTAAITKVLSKDGSAQFISYDEIDKAPEEKARGITINAAHVGYSTKFRHYAHTDCPGHADYIRNMISGASQMDAAILVVAANDGPMPQTREHLLLAKQVGIQYILVYINKADIVDNELLELVEIEMREMLSDFGYDGVTVPMITGSALKALNEDDSEYGMPSIRKLLDAIDNYVPSIQRDLTSPFLMPIDNAFTVPGRGTVVVGTLKQGASQMDAAILVVAANDGPMPQTREHLLLAKQVGIQYILVYINKADIVDNELLELVEIEMREMLSDFGYNGVTVPMITGSALKMTMLNCWDLGLVLNLPYPIYKYLRRVLQRYFILYSLPIALAGDNVGVLLRGLKLRSVETGMLLCAAKTMKLSNHYKAKVYFLTRAEGGRKKPIFSKYSQQMFSGTWNIACRIDLEPTVDMMMPGDHGEVYLTLLEGMVMTSGQRFTIRENNVTVATGIVTETLPSIDVPKGKLGKVVKFEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFF1</accession>
    <name>A0A0N1PFF1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="11">HMG-CoA reductase</shortName>
            <ecNumber evidence="11">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_04583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15991"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="11"/>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFF1"/>
    <dbReference type="FunCoup" id="A0A0N1PFF1">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFF1"/>
    <dbReference type="KEGG" id="pmac:106715604"/>
    <dbReference type="InParanoid" id="A0A0N1PFF1"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879717" description="3-hydroxy-3-methylglutaryl coenzyme A reductase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="848" mass="90539" checksum="55A07EBA4C5C8162" modified="2015-12-09" version="1">MKMKVWGAHGEFCARHQWEVIVATLALLACAASVERGGATRVQRCAGWARACPGLEAEYQAADAVVMTFVRCAALLYAYYQVSNLQKIASKYLLIIAGVFSTFASFIFTSALASLFWSELASIKDAPFLFLLVADVARGARMAKAGWCAGEDQGKRVGQALALLGPSATLDTVLAVLLVGVGGLSGVPRLEHLCTFACLALLVDYLVFVTFYPACLSLVSDFAAGRKEIAADGLFSEAELKPNPVVQRVKMIMAGGLLCVHLTSRWPWSREGGLLEGALRDDAAPSAGDDPLFHSYVKWFSVSADYIVIATLLCALIIKFIFFEEQKNWIIDMNDMTVKEVVQSEKPMFSIGEEPTVKADTFTQTEELVAGDELQWPVLSPSSSAAKLNAKKRSMAECLEIYRAEGECATLSDDEVVMLVEQSHIPLHRLEAALGDPLRGVRLRRRVVATRYHAEAAIGQLSYLNYDYSKVLNACCENVIGYVGIPVGYAGPLVVDGKPYMIPMATTEGALVASTNRGAKAIGARGVTSVVEDVGMTRAPAVRLPNVVRAHECRQWLDDKDNYALIKEAFDSTSRFARLQEVHVGVDGATLYLRFRATTGDAMGMNMVSKGAENALKVLKNFFPDMEVISLSGNYCSDKKAASINWVKGRGKRVVCETVISGENLRNILKTDAKTVARCNKIKNLSGSALAGSIGGNNAHAANMVTALFIATGQDPAQNVTSSNCSTSMETCGESGEDLYVTCTMPCLEVGTVGGGTVLPAQGACLQLLGVKGAGLRPAENSARLASLICATVLAGELSLMAALVNSDLVKSHMRHNRSTANVQGAAPAPASAPAPTAAAAVLRVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFI7</accession>
    <name>A0A0N1PFI7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcription factor Sp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05058</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFI7"/>
    <dbReference type="STRING" id="76193.A0A0N1PFI7"/>
    <dbReference type="InParanoid" id="A0A0N1PFI7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001110">
        <property type="entry name" value="Krueppel factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF165">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="926"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="956"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ07568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1068" mass="113883" checksum="B169F964114E630D" modified="2015-12-09" version="1">MKVGGKTAESSACPGRGRTQGGGYAPRGRGGRRAVGLTKVEVLVSGLQHQLQAARACPGGGVAGGGGARAVRPAHRHFRFRQSSPAPNPPIVFPRKLCKVISSVASIVHQVIKSKHKQCGCDVVPAAAGRMPHASATPRPGHTISRGGCSFVHNGLGATHKTQFHFHSRYARSCRARALNSAPTRRARHVCIFCPPKEDAGARLYTHYYVLPTFNYYYRAAAPHPRRGGEERRSCCLPIIKTCLRGNETAILARNNSFERIKLHQVRQRWEADLRSAPNAFVYNRQFTRRSLAAGRENGASSITTCITIHVGEAFNWMHVAQFVKSRPRDLRWVDQRAAAALRATTPGSRHFKKRVATSLHWHSWRQRAAASAQPTWGPNNNKRKSNSNNNNTTGNELSAAIVNAASTVPNGIQVQQPQVISMQQLQQLLGGGGGEGATYQNAPQQLLQIHPQLLQQQAGGVYGGCLVGGVGGVAPMQAVTVDGQEALFIPAQHAQNFSGMGQVSLVNGQLVRTPVLPAGFLQNVMHLPAEQQATVTIPGSNISIPLSALAGNQPMITIPGNFSLPAGIQIPTSQAITISSSPLPSADKNGNAKETKSPTSPQGQEQQATVTIPGSNISIPLSALAGNQPMITIPGNFSLPAGIQIPTSQAITISSSPLPSADKNGNAKETKSPTSPQGQGGGVAVRGGVGSVGGMGVVPVQVPVSMGNGHTVYHTVHVPVHAPHHLQIIPQLQQMQTQPQVANVLTPSGQIQQIQIASLGNVQSSGGAQTSVSAAQTPATITLQAVSNPMQTEGVGQQQILTSSGQQLTVIPASTAVRNVVQMPTLGVGGLGGAVQLVPAVMPEASFAGQQIQQDPSEPGKWQVVTVSTGGGGGGGTASAGGGAECEKLREPSPTHGKRLMKRVACTCPNCDQGENRQVDRKKQHVCHIPGCNKVYGKTSHLRAHLRWHSGERPFLCNWLFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLAKHVRIHTKTRSTETTTTNQLMYSDSGDDSCDDKMMLTIETLHTAGEGDEKLVMIRPGTKLETEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFP6</accession>
    <name>A0A0N1PFP6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase C and casein kinase substrate in neurons protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFP6"/>
    <dbReference type="FunCoup" id="A0A0N1PFP6">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFP6"/>
    <dbReference type="InParanoid" id="A0A0N1PFP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07655">
        <property type="entry name" value="F-BAR_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="F-BAR" evidence="4">
        <location>
            <begin position="42"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="429" mass="49296" checksum="AEB2322FDDEE5904" modified="2015-12-09" version="1">MKEKRRAGRCRGKVQHALRYLGGAVCECRTVMSHHSDEQALLSVASDSFWEPGNYKRTTRRIDDGHRLCGELQALVQERADIEKTYAKSLRAWGKKWNDLIEKGPEYGTMEAAWKGGMVEAERLSDLHLGVRDRLVNDVIAQIKNWQKDTYHKSMIQLKERKEMDEAFKKAQKPWAKLLQKVERTRLEYHTACKQERTAQNQERNASGDSSLSPDQVKKMAERVSKCREEVSKSREKYQSALAEITGYNPRYIEDMTAVFERCQQMEAQRLTFFKDVLFSFHKCLNISQEPTLPQIYEEFHHTINNADHQKDLKWWANNHGVNMAMAWPQFEEASTEGPEARFAFLTAASTALERIAAFRPRLPSLWDALPLRLCFGGEDSKSRVAPSICSYSLHDGCYANPMFIPVREHGVGRHAPTAGVDQARLTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGK1</accession>
    <name>A0A0N1PGK1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGK1"/>
    <dbReference type="InParanoid" id="A0A0N1PGK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="19969" checksum="85F0FD5C49BF7CB7" modified="2015-12-09" version="1">MLAESEGFKIKFAATHDPDIYSVVKEDMSASGVFSLIQKGDVDIVFGGISLLRERSEAFSYLYEHLAYTDELVVLVKKAGPVAPWKNIYLEFTYQVSNAKDLEKYQMEPCIPNNIKGLINSMTGTKYDVDMDEDCNKIMTSMHTVIPNNFTGPTFLSGFMTYGGQCGTTALKVHLLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-03-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH26</accession>
    <name>A0A0N1PH26_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VASP tetramerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460128">
        <property type="protein sequence ID" value="KPJ17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH26"/>
    <dbReference type="STRING" id="76193.A0A0N1PH26"/>
    <dbReference type="InParanoid" id="A0A0N1PH26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VASP tetramerisation" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="46" mass="5171" checksum="2E34745E15D20704" modified="2015-12-09" version="1">MYDVQQVNGGGEGGCVSAAEWDAFKQDVLREMRTQLNQIKKEILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH73</accession>
    <name>A0A0N1PH73_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH73"/>
    <dbReference type="KEGG" id="pmac:106709497"/>
    <dbReference type="InParanoid" id="A0A0N1PH73"/>
    <dbReference type="OrthoDB" id="7416705at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28177" checksum="CA3E7B91F1F05D4E" modified="2015-12-09" version="1">MAPVKFGLFKARSKDHQEQPSTENLLQDNNSNYNVPGSPVPSTSKGLQEDLSPGSISMLTLDSDDDDDDPPSERNSPVRRGSDACRMDAQINYELLKSQTSIGDVSSHYNEYDEVEQYEMEELQQSIDLDPDGTSCDANSSEFDITSITASDLSIYCASLKKPKKSKSKEEQQMRDFGMWQASNIEVMQNLLSRSGTTDEQIKWEAIATARGLCTLTDTCTCSDCTPAKYLVGFNDGDAGMAATPLFSAINVGCTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI29</accession>
    <name>A0A0N1PI29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein transport protein Sec31A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI29"/>
    <dbReference type="STRING" id="76193.A0A0N1PI29"/>
    <dbReference type="InParanoid" id="A0A0N1PI29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="354" mass="38601" checksum="166E63E2744A364E" modified="2015-12-09" version="1">MKIKELKRTVNVSWSPAEQYPIMLAAGTAAQQVDASFSSNSSLELYSLNLEEPGMDLELKASLQTQHKFQKLVWSGAGVVVGGCDGGLLQFYNAEKLQTGSAEALVGTSSKHSGHVSALDINPYQKNLLASGASESEIFIWDLNNTSQPMSPGNRNQPYDHVQGLAWNQQVQHILGSTFANRCVVWDLRKNEPIMKLSDAQSRTRWRSLAWHPAVATQLCIASEDDQVPVIQLWDLRLAASPLVTLEGHDKGVLALSWCRQDPDLLLSAGKDGRLLAWNPNNTKPGGEIVVEVCQEAAWTFDVSWCPRCPALLSSSSFEQQVAVHALLAAPQLQTVGAPAAPPVCCLRSCYIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIJ9</accession>
    <name>A0A0N1PIJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIJ9"/>
    <dbReference type="InParanoid" id="A0A0N1PIJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="376" mass="42082" checksum="8234AAC4CC3F9E64" modified="2015-12-09" version="1">MNRYCDHQRVRGIADARWRAGGSRGCLGGCWADCAETTTAWTTTTRSPPPRELYHENKREEFVQCSTDSAGFASANEEEEVEASPLSPVATSSCGPADEEQFAANIDLRYGGQYLTPEQLPEFCNQLHHLVEVIRNIQSYAKVTGEYPSELEKRLEQEAREVAALACEARQAREVVARTRTQRRALHALKKQLTAHLATLRHTEIRELEGAVRVSDRKLYKSWEALKDSTDPAAFEPLLEEIKSKQTALECLVRLINNRRAGISRAALAPHPLPHPLPHPCPHPRATTMVTSPYHRPCIRLGLESATCNARKRHDIGRRATHKRRKRDSTREPRSVPLSGETSRHGATVTVTVGQPTSDLTTTRASVRDILFFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJC4</accession>
    <name>A0A0N1PJC4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01056182">
        <property type="protein sequence ID" value="KPJ21565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJC4"/>
    <dbReference type="STRING" id="76193.A0A0N1PJC4"/>
    <dbReference type="InParanoid" id="A0A0N1PJC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="18101" checksum="3FA054677B17B822" modified="2015-12-09" version="1">MVSRATASIYMCVYCRLDCLRRISKGTVDFGVFSPEDLVAARWANVDVLVTNELRDRDKQFERSVVAVVNRRILPDSAAPLTSILRNSSLCHPGVGLDDLRPLSDTLSGVILHFISFYPRLRPRGIKKMHTRQKSFYVRLLVLSYLPINFRLNQFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJM4</accession>
    <name>A0A0N1PJM4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460037">
        <property type="protein sequence ID" value="KPJ18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJM4"/>
    <dbReference type="FunCoup" id="A0A0N1PJM4">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJM4"/>
    <dbReference type="InParanoid" id="A0A0N1PJM4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="18716" checksum="2BA042D0FAF0C085" modified="2015-12-09" version="1">MKTLVMLDEQGEQLDRIEEGMDQINADMREAEKNLSGMEKCCGICVLPCNKGASFKEDDGTWKGNDDGKVVNNQPQRVMDERNGIGPQAGYIGRITNDAREDEMEENMGQVNTMIGNLRNMALDMGSELENQNRQIDRINRKVMSLYVYTEYVNFNRYYLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKG6</accession>
    <name>A0A0N1PKG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459647">
        <property type="protein sequence ID" value="KPJ20520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKG6"/>
    <dbReference type="InParanoid" id="A0A0N1PKG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="242" mass="28060" checksum="A19B5F47B671479D" modified="2015-12-09" version="1">MKRVKSQGNGIEKLKIKALKNSNLIGVTPTESNKDVVKSNVGGEQPKKEEKPKAGGGDKPKAGGEAPEEKKQKKEEKKAAEAPKKEEKKQEKQQKREETQKKKEAEAPKKEQQKQEKQKEKEEKKAETQKKKEAEAPKKEQEKQEKQKQKEEKKAEAQKKKEAEAPKKEQEKQEKQKQKEEKKAEAEKKKEEKQKQKEEKKQEAEKKKEDKKQKQEDKTKKDEADKKKAGEKSKKAEEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKK0</accession>
    <name>A0A0N1PKK0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01037929">
        <property type="protein sequence ID" value="KPJ21328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKK0"/>
    <dbReference type="KEGG" id="pmac:106707306"/>
    <dbReference type="InParanoid" id="A0A0N1PKK0"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="52659" checksum="5010E337800DAD83" modified="2015-12-09" version="1">MGEDRVRPSALLVQGLSTFAIAYLTSLTGLIYGWPSYTLEMFQSNATVLSAPISTMEVSLLGSLTNVGGLLATPFCGYAVNKFGRKYAAIMYGIPFAISWGIISVARWPPLIILAVALGGVGAAGQAVSSVYISEIAQDSIRGALTSTTVSGYFVGLLFSYAIGGQLSYHQVAYVHLAMSLMYMVMLTFLKESPVYLIQIGKDKEAAESLAFYRRVPATSKEVEVEIAKIKLQMDPRIDNILQGENDPNATKELIEKQNDRTSRSESQWKFLMKSESSQQAMVAVLIVMSVTILMGSIVLQVYAEPLFKEAVPTMQPNLCSVLLAVTYLLASVLCAFMVDKFGRRPLLTITSVGSALCTLVLGSQLQLHWGPHWLTAATIYAYSFIYNFGAAIVPFVLTAEVFLPEVRGLGNSMSMACMWIMNFVTLIIFNPLVDWLGLGPVFYVFSCICLLGATYSHFWLPETKGLPADAIQKLFLKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLC5</accession>
    <name>A0A194QLC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLC5"/>
    <dbReference type="InParanoid" id="A0A194QLC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="10275" checksum="919F0F10004CB294" modified="2016-10-05" version="1">MNNKVANLQNSNAFVDARHLAYSGFIIFWNVCDAFDSPALSCRQLVVMMWRWWPRGVRRRRRVAITWPPSSRHVATRRTLSEATVART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM17</accession>
    <name>A0A194QM17_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM17"/>
    <dbReference type="STRING" id="76193.A0A194QM17"/>
    <dbReference type="InParanoid" id="A0A194QM17"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="17347" checksum="5B50A307FA8E5FED" modified="2016-10-05" version="1">MEVIEDGNIMDRIPILLQRDFQYYQEKQTVLSEKICQGVVGGRLDFPRNASFAAVKIVLWLEEEFQIAFNQGSGMFVKIDGENRIGGVVKTSDPEKFVQLAVKAGDFLLEHLHTLAQEALDHADLPVLTATLGAAALLKNTFYYYVQHVEESGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNZ1</accession>
    <name>A0A194QNZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNZ1"/>
    <dbReference type="InParanoid" id="A0A194QNZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6652" checksum="A107838EE07F7763" modified="2016-10-05" version="1">MVAVSELHLRRRDGIIRTRETNGSSDLFTACCRYNVKHAMAAAALSESNDHPPPGLEASID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQT4</accession>
    <name>A0A194QQT4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQT4"/>
    <dbReference type="STRING" id="76193.A0A194QQT4"/>
    <dbReference type="InParanoid" id="A0A194QQT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="45383" checksum="6BF0C89590E59750" modified="2016-10-05" version="1">MDAEIEVVSAESVRLAAVLTALIEEQSAPAKRKGDSATDESTNPKVAKNVTDDKKTAKSDTDIMSLLAMPSSREKAVKRVGEEIMDLLSKPTAKEKSLADKFKSQGDKPGKQYECKKLHFKKIIQSHTDESLGDCSFLNTCFHMDSCKYVHYEVDNADPNITNKTTNEPATKNSHNGATIVPKPDGVLTLTPPQWIQCDLRYLDMTFLGKFAVIMADPPWDIHMELPYGTMSDDEMRCLGVPQLQDSGLIFLWVTGRAMELGRECLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPENLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNVQPNWITLGNQVDGVRLVEPDLIAAFKKRYPDGNCMAPPADPLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRN4</accession>
    <name>A0A194QRN4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRN4"/>
    <dbReference type="STRING" id="76193.A0A194QRN4"/>
    <dbReference type="InParanoid" id="A0A194QRN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14518" checksum="FB00FB959A84626B" modified="2016-10-05" version="1">MNSFLNEVTIIILDHNLITYKPFSNDSIQSCARGDYLKVYWEVQGPGPPGAINERSAWARELCGSRSEVPSALYSPGQALVLEFHTGPKQNNATGFVGTFSFIDKHKRKRLKRPTYVKYDDCYHTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTA4</accession>
    <name>A0A194QTA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-dependent kinase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTA4"/>
    <dbReference type="STRING" id="76193.A0A194QTA4"/>
    <dbReference type="InParanoid" id="A0A194QTA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="35019" checksum="C6BE64814198CC07" modified="2016-10-05" version="1">MSVVPVIDMSEFYVVDQPDQLMIYYVRCQDAFGCERRVGYSEKPTQDVAEPTGPAARKGVLISFRTGKTMEIPEKDILGRCRFVGEFEKLNRIGEGTYGIVSDFGLARWLGAPARSATPRVVTLWYRAPELLLQSPKQTPALDMWAAGCILGELLANKPLLPGRTEIEQLELIVDLLGTPSDAIWPEFSTLPALQNFTLKQQPYNNLKQRFPWLSAAGLRLLNFLFMYDPNKRATAEECLQSSYFKEQPLPCDPKLMPSFPQHRNLKGQQKSSSNQLNIPLSNLNTGANDQTNNLPAISDLLGSLVKKRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTT9</accession>
    <name>A0A194QTT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTT9"/>
    <dbReference type="FunCoup" id="A0A194QTT9">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTT9"/>
    <dbReference type="InParanoid" id="A0A194QTT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="462" mass="53321" checksum="C02114B03AAAEA10" modified="2016-10-05" version="1">MNLNLKESFERWCRLCAEEQEVTMMIFSAEAEAMLLHDKLNKYLLIEIDEDDNLPKNICIQCCTKLQTVCEFIDKVKKAQDKLTNHCLVINSIKNERQSSSQIETEQETEYDIENISKDSPMEICVDPMMVLQNSDDTLSPFTENGDDNVEGVMHLNGIDGEDVTIKLIKRVGLVKDKTESTVKQFHCVICKRGFVTDLSLKNHSWTHINDKTVKKYNCSSCLEGFDFKGDLIAHFKKHRTKGRCQLCGRKSEKNLSTHMAAHMSKGNTYTCQICLRSYNTMSNLKTHSITHSNERPYKCHLCKKTFKRNQDLKFHINQHTGEKPYKCPFCEKSFASSGNCYSHRHRMHPGKQIEGKAHKQHLVPLVTNESGATDLQMAAYKSPMTSVKGIFKYQCQQCGHSFMKRDNYLYHMYQHTGEKPFQCTHCNETFVTRKGLLLHYDKKHPGRDRPLALLTRNALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU46</accession>
    <name>A0A194QU46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU46"/>
    <dbReference type="FunCoup" id="A0A194QU46">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU46"/>
    <dbReference type="InParanoid" id="A0A194QU46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="431" mass="47693" checksum="C2D65F4A2ED83B51" modified="2016-10-05" version="1">MTVGETGKNLPWVEKYRPSKLEDLVSHDDIIKTIGQFMKENQLPHLLFYGPPGTGKTSTILACAKQMYTPQQFNSMVLELNASDDRGIGIVRGQILSFASTRTIFKAGPKLIILDEADAMTNDAQNALRRIKITILGEPFTGKSSLCQRYLSNSPRAPGGTTHGAEVLAGQCLGLRPPVPLQLCDVAGNSLSTGMLRNYLYASDVVLFVYDLSNLQSFDKLNVWIEKVKEIFDQETKKPLMALFGNKSDLEHQRAVRLSCVKQFASKYLLENFKGSARTGEMISEDGIQALLELSGGDMRKVLNTLQSTWLSARDVTEDTVYTCVGHPLRADIDSILTRLMNEDDFGVCFKFIQDLKILKGLALGDILTEIHTKIQRVKFPPDVLISLLIKMADSEARLASGCSERIELAALIAAFHFARQQIDISAITNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUE1</accession>
    <name>A0A194QUE1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cAMP-dependent protein kinase type I regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUE1"/>
    <dbReference type="FunCoup" id="A0A194QUE1">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUE1"/>
    <dbReference type="KEGG" id="pmac:106719180"/>
    <dbReference type="InParanoid" id="A0A194QUE1"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12097">
        <property type="entry name" value="DD_RI_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000013">
        <property type="entry name" value="cAMP-dependent protein kinase type I regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="247"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="42622" checksum="76C34C68618FF965" modified="2016-10-05" version="1">MESMEEQQCLHQCESYIQTHNIQLLLKDCIVQLCLNKPENPVTFLRQYFQKLEREQVKAAAAAAATSEGEGDGELSPLPLPAGQPPRRRGGISAEPVTEEDATSYVKKVVPKDYKTMGALSRAIASNVLFTHLDESERADMFDAMFPVQCLQGETVIRQGDEGDNFYIIDSGEVEVLVNGELVTTIGEGGSFGELALIYGTPRAATVRARSRLKLWGLDRDSYRRILMGSTIRKRRMYDEFLSRVSILESLEKWERLTVADALEPVSFNDGETIVRQGEPGNDFYIIVEGTAVVLQQRGLGGESEGEGEGGSESAGEAVEVGRLGPSDYFGEIALLLDRPRAATVRASGSLKCVKLDRARFERVLGLCADILKRNIAQYNSFVSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUH4</accession>
    <name>A0A194QUH4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUH4"/>
    <dbReference type="FunCoup" id="A0A194QUH4">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUH4"/>
    <dbReference type="InParanoid" id="A0A194QUH4"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF11">
        <property type="entry name" value="BESTROPHIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="677" mass="76249" checksum="FB2F150C34EB7E54" modified="2016-10-05" version="1">MTISYAGEVPNGSSFGCFWRILCKWRGSVYKLVWRELVAYLTLYYTINLLYRFALNEHQQRVFEKVRQYFGAQIESIPMSFVLGFYVSLVVKRWWEQYKLLPWPDTLALFISAGIPGADETGRLMRRNIVRYAILAYVITLQRVSLRVKRRFPTWQHVVDSGLMLESERKVFEKMDGKSPMSKYWMPLVWATNIINRARKEGLITSDHIVQTLLVELSDIRRRLGALIGYDTVCVPLVYTQVVTLALYTYFVAALMGRQLLPPAPGSTSKYEPDVYFPVFTALQFCFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLKDQYWEEVVPKDLPYTVASEHYRRHEPPCSADHYKVKAEDAVYANVQIPRKSNEETYADYESVDTPLVERRKNWFQRQISRMESVRSASTAYSSGGLFGRNRHNSVVYSSPEAGQATAAAPPHHKMSLYERLVGRKSVRGQHRQNSKHGQKSNGSAIPITLRNRPRIPTPDVTKEVIDRENRLAVGMQNMGVIMAHQGYQNEVPVLGALVLSPIQELDSGSVNNTLHAGQPGTTALAQAVLSPNLTSTGLAPMLTAAPVVSSVTLSPMGVSQLTLVNGSAPSTPRTERGKGVIGTPLSPRTTVVEVASSDRDSEHSATSTATAPDFTRKPNGSKRGEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUU8</accession>
    <name>A0A194QUU8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUU8"/>
    <dbReference type="STRING" id="76193.A0A194QUU8"/>
    <dbReference type="InParanoid" id="A0A194QUU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="64"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="179"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="334"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="435"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="791" mass="88365" checksum="C0F0C73DFCD27CBA" modified="2016-10-05" version="1">MVATTQRESVRDAPLTPPLARCHTDGALKVRSCNGTALCHTFTMIFMRVFMCSIWFVGAFSLEADVVVLRAVRGRDARLPCGQGKVFLDGPDSYVLWLKNDRDFLYRFPNENSGSRSLNQDRIFGTSCESGSCHDDTSLLLKRVSDQDAGIYRCRVHYQASPSQDYVIDVRLVESPGMPRVYSNSGVLIKQGYVGPLSLGSDLTLVCEVDDEQPDTLVYWRRNGVVIERAHEARPGVLRAEVLVRNATRSELDAHYECLAQNADVTEALTASVVIRMYCKFQCFFSWQLNFSNVLKRHDDTSVLALVKKLFLYESSACKNTLHDHSEELKTIVPPISVEIRLNHNFNFEAGQPRVVDCVVVGCVPPPSITWHLGDNLLRPSVHKELHDGNYTVSSLTLAPSLRDNKRKLVCRAHNSHLPDEVFEDDVTLNVGYRPLCLTSREETVGAVQREAETLTCIVEASPEPIQFSWTFADSKTLYTSVKKVPGHHHRYSSTLTWLPRDGDFGLLYCRATNSFGEQKKPCTYSITSGGPPQSPDCSILRSYPHTVRVECQKGWDGGRPQIIHLELFGSEGGLLHNVSNSAGHFHLSDMEEDNNLTAILYASNNRGRSSSKTMYLQAASTLNASAITEHPTVTLKGQWLQALAGLLTIIVIIAIVGVCLRMRCKHEDSESPDLVLRSDGVFHREPDFEREERLLRTTNITVNQLAACQNATDLNGNECPWDILIRTAFHDLPQGVYTEEQLFSHFTRARNGILQQYASSPVPSCRVLVGCGSRLPPQDTCPASQHSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUV1</accession>
    <name>A0A194QUV1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein apterous</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUV1"/>
    <dbReference type="STRING" id="76193.A0A194QUV1"/>
    <dbReference type="InParanoid" id="A0A194QUV1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09377">
        <property type="entry name" value="LIM2_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000177">
        <property type="entry name" value="LIM homeobox 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19035" checksum="CA33DF50CA501499" modified="2016-10-05" version="1">MVGDGWGFGRLACDTVTTWGEAQTLYGSKRCARCNTPISASELVMRARDLVFHVHCFSCALCSTPLTKGDTFGIRESAVYCRLHYETMPDYGPHMAVPGPPQMCPGPYAVPPTGSHYPPYPSPEFAPVEPDVPKGPFFNGAAAPPPRQKGRPRKKKPKDQEIMTANLGEFSEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVA8</accession>
    <name>A0A194QVA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Sodium/potassium/calcium exchanger 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_15395</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVA8"/>
    <dbReference type="STRING" id="76193.A0A194QVA8"/>
    <dbReference type="InParanoid" id="A0A194QVA8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF2">
        <property type="entry name" value="RE48874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="19 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="6 20" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18 20" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="22">
        <location>
            <begin position="430"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="22">
        <location>
            <begin position="685"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ09254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="853" mass="95713" checksum="9742C3F67C513DB2" modified="2016-10-05" version="1">MGKDRKDKAAYLSTLNGLRPIGWPRYCWRYAVELDLLQLQAMVWQKKAQDRQLWLSLVLEANAHFGSKRQRIEGCWAFAVGLSFICGAYFVITAYQWYARNPIVTVIESTQGAIWDVPFPAVTICDLNVVSRKAAFALAHNFDLIYMPTPRRVASCGYETALTVLIRTDTDDYYSTNIATTGTLVYIDNAYNVPDFDSTLRLINPMTEVLLALSPERTYSTPGIKSFGIEERQCYFNDEQSTATRSARYGVRSASTLLSTIGRDNRIINHTVARCQRVQHGRWDFGSSASTALRGRIETEKETDYIELVQLRQHRRNFKMHSIASCFIILVCATASVTSLEDFNSTSDTVFVPIVNNNGETVYVTKDLMRKLEDELETWHWTPWLRTRTEVAENIIREVECISGDSIDSFPDDTFTDDQLRRGAFLLYVLFGIYAFTLLTIVCNDYFIPCVEFICEDLKIPQNVAAATFMSVATSCPEFFVNVISTFLTESDMGIGTIVGSAIFNALGVAAIGGLAAISPISIDRRPVTRDVIIYLLNVIALMIIVWDGRVEWYEALVLGILYITYFIVMFNSLRIFALYDSIIGSKNRNNNGSKLNIVTNDNKSSGEGIDNKGFNNSEVVINNIPEKVAVNEKAEELEKPPKSVWRYPRENSLTYRIWWVYTWPLKLILAFTIPLPSKYRKFYPLSFIMCIVWIGVNSYFVSWSMTVIGHTFFIPDSVMGMTFLAFGGCLPEACSIFIMSRRGEGGMGVSNALGANSLAILFALGLPWLIKTLTLVGQGAENTAVYINSAGIGYIVGSLLVAVAALYVTLFLGKFQMRKKLGAVLIVLYAIFITFAILVEMGIIVDKGIDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW95</accession>
    <name>A0A194QW95_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW95"/>
    <dbReference type="FunCoup" id="A0A194QW95">
        <property type="interactions" value="1955"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW95"/>
    <dbReference type="KEGG" id="pmac:106716755"/>
    <dbReference type="InParanoid" id="A0A194QW95"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="370"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="772"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="960" mass="107191" checksum="10FE0D20D33F894A" modified="2016-10-05" version="1">MEDEIDECIRKRIQWPQLPTTVKKVLGDSPKEYERYIFEFSVKNQLRYRGSLVRTVRKDERKYYEVLVQNSIQRLMLYPYHLADMIVKGLRITPFIYYLEVVALLIEMEKSYDTMPNFTAADCLRLLGIGRNEYLELVAKSRSLGRRGRSKAIRGLLPRVPLNIPMLPWWRVELGYVLEEDVKPLSESEKSLIDLLIDRGSQTAGTLDYNVVKTLYRRGLIYLDVPITSADKVSVPPLKGFVMNRIAGDYFETLLYKVFVSIDEHTSVAELAAVLQVDCELVKQAVSLYCRLGFANNLNPPPVSPQHPSWKEAVTTHKHQPYRQIAPLTFDQTMDEDALQMEPVLIKDMPSTSKQSSQDVIEAGSSNNGQRVAVLFDSTLAAYLMMGNLSPDLKSHAVTLFEVGKLCDESLDSLLMELDKVAADPEIEGEARRYLAAAACLRTALRTLRPRLRPLDLLRCEALHALGPAARTRLLSTKYRLAISTAPLSREARAGVAAGALPHVGPAPPEAASPWMRLYFYHVAGYGPPTLLLTKGTVLRSVPRPLLGYARLSVTWWGAEGEPAPLPAAAALAAANSALRRAPVLLQAAAVRHHPIVKYVAFPTVDDESQSIWRTHTGLRRLARRLRLSRAAGYVALADTGVPDLGCAHPPHCVQLVPQRKKKEVCGIAKPISEVSLSSNESVEKSTEYTKLVNSRLQSPIESHFAVTPTTDSKTSSPANGFTSVEGGKLLCEELDNLNIDDNFVHRSKESISASDDFVPVHSSSTSIEELKKHSKEKSISKESISFSDDLVPIHSTSASVENLKFESKKNEEDKNRNALNDLLSPAEESISMFTQLSDKLTEMTEGDSGVDTAHNFSDEETCKPEKWTILDLQFGIPLFDEALCEKICHSIVDRIARPEILEKIKEDNEFIRADVLKFVSQCQYYPGEDMGIVKRGSLVPLPRKNLVFENGRITEWNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWI7</accession>
    <name>A0A194QWI7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWI7"/>
    <dbReference type="InParanoid" id="A0A194QWI7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="18591" checksum="15732DEC6DDB1A61" modified="2016-10-05" version="1">MAGVSQPYGSHKISCHALSRLGTRSVLGGISKPVRCGYLSPRASFRHAQRAHSPTTKSTRNGRSKKRVERAKCAPRSPLSAVTHASAPPDSRAGVAISIACEPYARRTRAFARSRPGSHPYPTPRPLHKTDARQINIQLDPPQPVCFCRTHCRRTFCYVTRKQTPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXB4</accession>
    <name>A0A194QXB4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_12955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXB4"/>
    <dbReference type="FunCoup" id="A0A194QXB4">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXB4"/>
    <dbReference type="InParanoid" id="A0A194QXB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264709" description="non-specific serine/threonine protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="691"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="14">
        <location>
            <begin position="954"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133772" checksum="800A567387CFEA02" modified="2016-10-05" version="1">MKSLVIILLLIGLGGPVCAEKEKKDSTELSRALDDRPLLFATLGGGMVAVEPGSGNIIWKLKDEPVVKVPNQHANLMPQFLPDPRHGSLYMYGPRGDKQMLKKLPFTIPELVANAPCRSTDGILYTGKKSDTWFMLDPLTGSREHISGFDKSKIFKSDEDNTCEPDKRRGVYVARTEYNILMHDSKNENQRWNVTFYDYTSHAMGKEMLNDYGIIHFASTSNGRIMSFDRKTGDLVWSHNFETPVVAAYLLDREGLISVPFNSIGDDTLDHIMEDATTLRNGQGIKNSNIELYPTLYIGEHNHGLYALSSLVDKNTVTISTGYTHPLLLEGPVAEIQASTETPTYEPLSHIHYKLSDLNLHVSPPYLLLGHYKVPELTTSWMPQLPTANLLKVPERHINGMKLINGRMQAETEKDVENETNLKSNSISVSVQTDELFEGFGFRPDLWYKQGYVWLHQQENKALKVALIILMGLVVAMFWYLRYQAREFQQLSQGGSRGSTVSNASSQGEVTGQLVDLGDGEVRIGKITFHTDQVLGKGCEGTFVYRGMFDKRAVAVKRLLPECFTFADREVALLRESDAHAHVAREFQQLSQGGSRGSTVSNASSQGEVTGQLVDLGDGEVRIGKITFHTDQVLGKGCEGTFVYRLAREFQQLSQGGSRGSTVSNASSQGEVTGQLVDLGDGEVRIGKITFHTDQVLGKGCEGTFVYRGMFDKRAVAVKRLLPECFTFADREVALLRESDAHAHVVRYYCTERDKQFRYIALELCSATLQDYVEKKLNFECKIDAVEVLRQATLGLSHLHSMDIVHRDIKPHNVLLSMPTGSGEVRAMISDFGLSKKLNIGRVSFSRRSGVTGTDGWIAPEMINGERTTTSVDIFSLGCVFYYVLSRGQHPFGDVLRRQANILTGDYSLEQLDKILPEEELVVTKILIRAMISSRPQLRPPCETVLKYPMFWGKQSILNFLQDVSDQVESCSCAGAEHPLERGARRVVRGDWRVHVSAPVAGDLRARRTYRGERVAHLLRAIRNKKHHYRELDSEVRDSLGKLPDGFVTYWLRRFPLLLPHVWVQMQQFRQEDILQAYYPHSYAFNRDDVYELTDEDIEEPQEVRDPDKNELFLKSRIYFDEKKDQERFYRYKSPKKIVDWRNESSNLRLQDDVRLRDRFYKKKEKKKDEFPIWTLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXK8</accession>
    <name>A0A194QXK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXK8"/>
    <dbReference type="FunCoup" id="A0A194QXK8">
        <property type="interactions" value="1822"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXK8"/>
    <dbReference type="KEGG" id="pmac:106718208"/>
    <dbReference type="InParanoid" id="A0A194QXK8"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22297">
        <property type="entry name" value="PSMD4_RAZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049590">
        <property type="entry name" value="PSMD4_RAZUL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="367" mass="39998" checksum="8AEDF8DCAA51E85B" modified="2016-10-05" version="1">MVLESTMICVDNSDYMRNGDFLPTRLQAQQDAVNLVCHSRTRSNPENNVGLLTLANVEVLATLTSDVGRILSKLHRVQPNGNINLLTGIRIAHLALKHRQGKNHKMRIVVFVGSPINTDEKELVKLAKRLKKEKVNCDVISFGEDAENNPLLVSFINTLNGKDNASGGSHLVSVPAGGCVVLSEALISSPLIGGDGAGPSGSGLSPFEFGVDPNEDPELALALRVSMEEQRQRQEEESRRQQANTDTEMTEGNTGEAQNTGMERALAMSLGREAMELSEEEQIALAMEMSMQQEAPQAEESMDVPEEYAEVMNDPAFLQSVLENLPGVDPQSEAIRNAMSTIKKDKEEKDDKKQKDKDGKGGSSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYY3</accession>
    <name>A0A194QYY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYY3"/>
    <dbReference type="FunCoup" id="A0A194QYY3">
        <property type="interactions" value="1576"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYY3"/>
    <dbReference type="KEGG" id="pmac:106717487"/>
    <dbReference type="InParanoid" id="A0A194QYY3"/>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="46120" checksum="20A9692B58C9EB0A" modified="2016-10-05" version="1">MAVLAAAQLLDELMGRHRNTNPNEKIKKPNWEDPEYCKYFMVKFCPHDLFVNTRADLGACPKVHDDEVKELFQRAETSYKKSQYVEEFLRFCRHMISEVERKIQKGKQRLELMNSKPEGPPMTQAQTEKNQEQVKLLSEKITSLVEEAEEAGTRGDVEQAQGLMKLCDRLKEEKDQLLKQQENSHWSMTAELAAAQEKQMEVCPVCGAFLIVGDAQQRIDDHLSGKQHVGYFKLRQAYEEMSEAREKEQQEKEKKRREDRERDRHARSGGGGGGGGGGLGSDRRDRERMERDREQRDRSDKDRERDRGDRDKEREKERHRPVREEKGGRHEERERDGERHRERERERDRDKDRERERERDRERKHRKDRRSPHERSRRRSRERERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0F3</accession>
    <name>A0A194R0F3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type proton ATPase subunit D 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0F3"/>
    <dbReference type="STRING" id="76193.A0A194R0F3"/>
    <dbReference type="InParanoid" id="A0A194R0F3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="58056" checksum="424CF3BA77840AAF" modified="2016-10-05" version="1">MFKEDDDEEDNTFGVTRYPCMPSLVALQQMRNRLHLANLGKKLMKWTAVAAMTELRNIALQIDSVYKNFSEDMCEAFIMLARCRYFNPSLNQMVVEGCPNQAEICVTSSTRTASGVKVIKYEIIENNTHPYEHLGIGKGGQMILDTKKTWLDLLKRIILMVELRKNFKLVEEMQKSANKKMNVLGKVVVPKCKATCTYIIDALEELARDEFYRRKMILEVKGKGEKDPKCSSECSLICDEDENKPMHLAMNDHVTQILQLVNSIDDKKFSESDIKDFLGLGEELKSKLYDSIKPTSNFDEIDDKDNAKTDIPAEHKVQLDTQLNLPLDEKENMDPVEVEIKEITKIVRIRNKDGTYREVKKTIKIQKETKIIENTSNLSVSNNKVLYEPSTSSSKSTPSRETRIQMINLKNCNIPTQQTKVRESDKKLNTVLCDNLVLEKDLSESSLEIDMEYLKSKYFCTNCPICKELSSEIFKVQDIEELYEKYQLDEKNLFETEEMKGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R111</accession>
    <name>A0A194R111_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R111"/>
    <dbReference type="InParanoid" id="A0A194R111"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9657" checksum="553A11FDD03984AE" modified="2016-10-05" version="1">MDAGCGVSGQGGARLMRSSLSKQNRHAAAAPMRRAATAADALRLCLARLDVTRRPENKLAPHSSEITTPCNGTDKLVKYNHDTPTTINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R167</accession>
    <name>A0A194R167_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeotic protein distal-less</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R167"/>
    <dbReference type="FunCoup" id="A0A194R167">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R167"/>
    <dbReference type="InParanoid" id="A0A194R167"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF81">
        <property type="entry name" value="HOMEOTIC PROTEIN DISTAL-LESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="184" mass="20455" checksum="BC1BDAE083AABF59" modified="2016-10-05" version="1">MTTQEALEHQHHHLGGSQTPHDISNSINSTPTNVSSKSAFIELQQHGYGPFKGGYQHPHHFGSPGGQQNPHEASGFPSPRSLGYPFPPMHQNTYGYHIGSYAPQCASPPKDEKCGLSDDPGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQIIIQGFSHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1E9</accession>
    <name>A0A194R1E9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1E9"/>
    <dbReference type="FunCoup" id="A0A194R1E9">
        <property type="interactions" value="1678"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1E9"/>
    <dbReference type="InParanoid" id="A0A194R1E9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000027">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="467" mass="51509" checksum="3BD8594CB3BBDA07" modified="2016-10-05" version="1">MTFAFTFCPTSRILAYAYKRRHAVRYCGSLHMHSIEDNRVNYRHFHTTKVLNKNVAFKLSDIGEGIREVVIKEWFIKVGDKVQQFDNICEVQSDKAAVTITSRYDGVITKIYHEVDQTALVGQPLVDIEVDSTADDESSSDSDTESKVEIFKTQSQTTQKVKVLTTPAVRRIAAQFKVDLGTVNPSGRNGRILKEDVLAHLNMSADKSNEIPSALSVEAKPMAMSIGSVKIEEILEDKIVPITGFTKAMVKSMTEAMKIPHFGLSEEYDVTKLVESRESLKVIAQERGVKLTYMPIIIKASSLALTAYPVLNSSLDAACENLIYKANHNIGIAMDTPNGLVVPVIKNVQQKTILDIARELNILQEKGTKGQLGLSDLSGGTFTLSNIGIVGGTYAKPVIVPPQVSIGALGKIQVLPRFNSQGEVTKAHILTVSWSADHRVVDGVTMARFSNILKQYLEDPYKLLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1S2</accession>
    <name>A0A194R1S2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1S2"/>
    <dbReference type="InParanoid" id="A0A194R1S2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="9299" checksum="1C9BD1C21BE32ADD" modified="2016-10-05" version="1">MKKKKMDYPTEKQMVLQRKETTPVDFTRLVVMRLVYGFAKVLGFDEPVSEILDGAFVPPGADDDDDLFGDDDDEESIFDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1Z4</accession>
    <name>A0A194R1Z4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sequestosome-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_08018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1Z4"/>
    <dbReference type="FunCoup" id="A0A194R1Z4">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1Z4"/>
    <dbReference type="KEGG" id="pmac:106714365"/>
    <dbReference type="InParanoid" id="A0A194R1Z4"/>
    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endosome organization"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="12">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="11">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60850" checksum="594BD815CD300112" modified="2016-10-05" version="1">MEDKVQFKVYAYGKNQTKPEVRRFGIEKSVVTSFCYLDAKLQDIYSSLKHKRFTVTWKDEDGDDITISSDDEMITALSSMTDNVMKLNIHCHEEGPQEVDCDVVITASTENATGDRNAAHCGVICDVCDVPVVGFRYKCTTCVDYDLCSKCEAAGHHSEHIMVRLPMPNMARAVIKAAIRRSRHIMKSVGSATADLEQLCKRAKRDRSCEKKRHHSRGEHHHRRNQSSWFDIFSTYMNEFADLTGNVGLDTNKDKDKTPKPAEQGSQEQPQTSDNAASSTSKQPDAAATESECPFAVNINQEKIQKFLQMLYGDTDLNSAAQQAPEQSNVNNEGDSGASGQTSEVGKEDAKSEISSTNKDMNEATTRKDESPERGTEEWTVINKEKDLMDMDPKPSAPLEQNVPIGFNLPQEFQQHVKIGEGQSLYPPLHTASAVLNPKELEMLKPSQGVTKPQEAETVKQNVLSGQPKTVPLQQQPEGFKPNMSNNQTGTKQPQPQSSHIKPHIDAAIKQMQAMGFNNEGGWLTQLLQSTNGNIEAVIELLTPVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R371</accession>
    <name>A0A194R371_PAPMA</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460870">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
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        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264885" evidence="5">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="15902" checksum="FBBF4B1766D0B65C" modified="2016-10-05" version="1">MVLKTTLLFLCAVLVGITTAKKATIGVPSDIVGLITEKSVECIAETGADVNILQRIFNWQFDNNKTSKKFSFCLFKKAGFSDDTGHFHKDKILALYEKSDKKEEIKAAVMACDKISEKNPLETMYKVILCFFDKTPWYCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R487</accession>
    <name>A0A194R487_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R487"/>
    <dbReference type="FunCoup" id="A0A194R487">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R487"/>
    <dbReference type="KEGG" id="pmac:106713729"/>
    <dbReference type="InParanoid" id="A0A194R487"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="566" mass="67325" checksum="96CDD627A5DA42F6" modified="2016-10-05" version="1">MAEQVNQRIEGMINELEQMKRINLYDDDEIKEISRKRKEFEYRIQRRVKEKDDFVHYIAYELALLEDISLRRKRAQLSEKRNDIEYAIAKRLNKIFKQFIYRFQNNIEIYFEYIRFCRSVGFHHAISGIIGQMLQVHGDKPKMWQMASKWESKEQKNYESARGFLLKGIHRHPESDILYLDLFEIELILAFKSKDDEQKEVCIKRADVVWRNGMKTIDDIAFLFKVCDLAMKCGVEQLVKSIKDEIWSKRDNKEVWIYIANKELEGYHWEEIEEFINEDYYFPKEIKNYICIYEEALQQFPDEKLCTKFIHGLLRLNDASCTDLQKIRVVKHAWMFGHENGVLSNDMYAFGIELLKFDNTLSPEDFKKIIDSALAKNPHVRFLWEEKLLLNDKDEKQQLLIMKDAGKVLKADDYLHLWNVLLDNIQTSEALKNCYEKFKNCEEAVLLAIKPKLLNKMYKCSGLKATRDLYEEFIRTPPTQVEVHNVMIDIEKSQPKPNLKNIRKYFECLVQHHGASSIQVWTDYINFETQNGSPQNSPAIYRRAIAVLKKELVDEFIKNQTLSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5Q4</accession>
    <name>A0A194R5Q4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Factor VIII intron 22 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5Q4"/>
    <dbReference type="FunCoup" id="A0A194R5Q4">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5Q4"/>
    <dbReference type="InParanoid" id="A0A194R5Q4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039494">
        <property type="entry name" value="F8A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16797:SF4">
        <property type="entry name" value="40-KDA HUNTINGTIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16797">
        <property type="entry name" value="FACTOR VIII-ASSOCIATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32494" checksum="3F5248147410FB10" modified="2016-10-05" version="1">MSTDLSASFDEQRFMRKPNVSEATNEFIGLAIQCEHSEQPSFAGQTYIGAAKCEALAGNHLGEAEQYLAAARQFIKAEAKLLALKFYSPDRENLEAAIGCYLQALSKYPDKSPIRTSVLMELANNLVSLNHKLEAVTYYEEALETVNDSTMKLLYMRNLLNLLIDCGKYDNALQLANKIFDSNNHIPDGILTEIQVSRILLTLLVKPDEGTKIESLKQLFNDLMNDTESEAIPFNIDLKLKLQSIIICSTIGDLQSLIGVAPDTKSYLTSQQADLLHALYSEQKDYNFVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6G0</accession>
    <name>A0A194R6G0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_15090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6G0"/>
    <dbReference type="STRING" id="76193.A0A194R6G0"/>
    <dbReference type="InParanoid" id="A0A194R6G0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264952" description="Multiple inositol polyphosphate phosphatase 1" evidence="14">
        <location>
            <begin position="20"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="932" mass="107903" checksum="78F4EF49C1F15F84" modified="2016-10-05" version="1">MKSLLILVTILYTTKTSYSSCYWNENCHYKYFSSKTPYEFVRGDIRDSVVIKPGCKTISLWGLVRHGKRNPGENFIYKMLDATILKDYIKTSHDKGNGSMCAQDVENLYNWIIDEDTFRNVHQIAKEGYEEMAGLGHRFSAVFKDLLINADENNYTLRSAYGHWLENSVKGFIKGIGNESLIVDKSNKSYDIMAPYESCNYYMKGVKQNPDIYREPTKYQDMNEFLSVKDRIQTRTGINYTLTNENITSLYDLCRYTSSGTHKKFSPWCALFSTEDIKVMEYIGDLRHYYRNSYGTPVNKIFGRIPLTDLLETFINTKNGKGKQFTIYFTHATMMDMVYTALGLFKDEVPLTAEFRNDARKWRSSKSTAFASNLMVTLNRCTDGEETDYNVVFYLNERPLESICNNGECSWREFEEKLKPFNISLIVTISLFASTFASFCHWNSGCPYKYFASKTSYNAIRGDIRDSLVILKGCEPVSIWGLLRHGKRYPSTRFGKSMNEALAIRDDILASYEKGRSSLCAQDIEDLNAWVADKKMFDAAAELTPEGYEEMFGIGKRIRHTFNDLLEKLDKYTFRPAFGKWIEDSAKAFVKGFNNDKLHIEKALPESDVMAPYLTCGKYQKDVQKNPNIYAESEKYKRTSEYLATKDRIQRRTGIDYELTDTNVTALYDLCRHTWSGVESKLSPWCALFTKDDLQVLEYIQDLRSYYRNVYCTAQSEIFGQIITKDRIQRRTGIDYELTDTNVTALYDLCRHTWSGVESKLSPWCALFTKDDLQVLEYIQDLRSYYRNGYGTAQSEIFGQIPLADLLRSFQKVKEGDGKKMTAYFTHATMLDMVYTSLGLFKDNKPLSSANRDRDRKWRSSANSAFSVNLVAVLNRCTKNYEIDYNVVFYLNEEPIRAICADGTCTWKEFEEKLTPFLNTKIDFCEFKSEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6M8</accession>
    <name>A0A194R6M8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium voltage-gated channel subfamily H member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6M8"/>
    <dbReference type="STRING" id="76193.A0A194R6M8"/>
    <dbReference type="InParanoid" id="A0A194R6M8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="717" mass="84451" checksum="56C78DB1B00AE735" modified="2016-10-05" version="1">MIAESLLKLHCIFSFHPIVQIIIGEAKRRNPSPKAYVDVKNFYELMWKKHDGITRLPNIMSELPRYLRVEIKQDLVWAVFYHSPTLRKTSRAFQRWLCDYIHLDYKLPGSRFFVGPHCYSHLYYIKSGIVQLISMDDGITPIISFTSGTIIGDISFFLSPLKRISMVRCLTYCEVFYLPRADILKAMHKFPVDSKAILQRVKEKIKHAHTLYSCKKHVRGLDRAEDEGIAWLKKRWWEISEVVSHFNVPEDQHSKPCLKLVEEEVVYHCPKYLGQLVLCTDGELRKHSLFASVRFPLLLVPNSSFSVVWNRIVVATVFLVLIFYPPNITRPDVPVWFNFFQFWADIVYLADVCVSLITTMENQETGRVYFASVMFARFKNVWFFIDILSATWFETYTRLIGMPQYYYTVQFNRLLKIYVLFPNWSFGKDPLIHVIVKVCLIHLIFVYITSYLTLALITIIPDLSPVSFFGEIFCNREVPKNQCIYKVHHVFEIFLAWVLEFLFSHNTTQNLTDVYMSTVTVYFGYLIFIYCKTALIGIFHASNTGISKYQYFVINITNHYKQFKIHPELLRRLNRYMKCHWKYYRGMDVLYPNVLKNEPYDIYWKVHGEVAENIIRQSPPFLLADYGLIRELAYNAKFILLPKLSTVIIFGLQPKNVTWLVQGYIKSEYHNKEGELIRSMYKPGDLLAFTSVFFNKPPLRTYMAYTECEVFISFLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R877</accession>
    <name>A0A194R877_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_06436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="11"/>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R877"/>
    <dbReference type="FunCoup" id="A0A194R877">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R877"/>
    <dbReference type="KEGG" id="pmac:106714132"/>
    <dbReference type="InParanoid" id="A0A194R877"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="796" mass="90816" checksum="E03C83709856C097" modified="2016-10-05" version="1">MVGKINKLYVYKRGGRMEEVHIDKITSRIKKLCYGLNMDFVDPVSITLKVISGIYSGVTTVELDNLAAETAATMTTDHPDYAVLAARLAISNLHKETKKHFSDVMTDLYNIVNPHTKKRSPMISDFHYNIIMKYKERLDSAIVYDRDFKYNYFGFKTLERSYLLKINNKIAERPQHMLMRVSIGIHGEDIDSAIETYNLLSEKYFTHASPTLFSAATPRPQLSSCFLIAMKDDSIEGIYDTLKQCALISKSAGGIGLHVHCIRAKGTYIAGTNGVSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHSDVFEFLDLKKNTGKEEVRARELFYALWIPDLFMKRVEKDEMWSLMCPHDCPGLADCWGEEFEALYEKYEQEKRFVKQVRAQELWKAIIEAQVETGTPYMLYKDSCNRKSNQKNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNRFVNEDKTYNFIKLKEVTKIITQNLNKIIDVNFYPVPEAKNSNMRHRPIGIGVQGLADTFVLMRIPYESEEAIKLNQQIFETIYYGALEASCELAQKEGVYSTYEGSPASQGILQYDMWDKTPTDLWNWSILKDKIAKHGLRNSLLLAPMPTASTAQILGNNESFEPFTSNIYQRRVLSGEFQVVNHHLLRDLTQADLWDEDMKNLIIHNNGSIQNIERIPKDIRELYKTVWEISVKTTIKMAADRGAFIDQSQSFNIHVAEPNYGKLTSIHFYAWKMGLKTGMYYLRIKPAANAIQFTVDKSKVRASNGRMESDDKNMSMIACSLRNKDECLSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8L6</accession>
    <name>A0A194R8L6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8L6"/>
    <dbReference type="FunCoup" id="A0A194R8L6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8L6"/>
    <dbReference type="InParanoid" id="A0A194R8L6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF7">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="503" mass="58947" checksum="5B3928B1186A2897" modified="2016-10-05" version="1">MCTITENNIYLLCKHLDIDECQAKLLQLKQPVLKEISEKEFKTVTETVKELGFSTQTLILNPALFGVLPITLKYRYKVLEECGLQNIKPGDLLRYLNIVKQKTIGQLRSDGQIPYYLNIENRLASCMTQWPTSLTTLIYGDVNNFSLYSLRLKIIQRYLELVLDLSSDEFYRGLKTYPTIKHRPLEIINETLNILQTQIMIPNFKIKSNLYLIHADPENLKNLIYNFRFIGGIDIKEIIRSHPKIAMKNFSNMVEIRKILQEFDVSNEAQIRCFEIYTLSPETIRARLENAKKTPEFITYFNHPRFLKMIHHNKKTTKRLINLYSQNKKCVSLNILSGSFSNYETFEKMHGDRLGKAKDLLFCICEILGNTSSASDIRKILRRHPFWLNMPLVQIKYVAEQLLKKFSPEDVFENCTILLYPWNKIRDTMVILHHRELLKLHPFDHLDMSRLSDSQKLSLVLYLLEKKHYFTGNGVWTEDKNKNTELTIQTKNISKSILKIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9G4</accession>
    <name>A0A194R9G4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9G4"/>
    <dbReference type="InParanoid" id="A0A194R9G4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="822" mass="89243" checksum="7580E4C04DD5DBCF" modified="2016-10-05" version="1">MNARSSLGEIVNARLFIYTFRLLPPPAVSTRTALTTREHTAAYTYRITDSQSNTLFIKASIQTRFIRSDITRGVGRGESSRNSATSRPALNRSHSRSSRSAARWSCPCLNIPWRCRSPYVTLGAVRYTVRRVPPPRACPCRCCSEEAVAACLGRAKPDRRTLERLHRRLGRGARDDRPSRHQRLQDLTKRLLPRAQPPQPPPAPHTPPAPPPHSAPVLPPVPPPRSRHRHSPPRGASVDRYDDFDADNITLVRVEPRAIVGSYAQKTIPYRSASFSQGDFAQDKYYRGDRQRSIFDFGKKTAKTDSGHGGTDPSNADTRSLATEENVTEGGSVASVDSAVGSDEGLLAHASPAPRSPPPEGTHKQFGGRSLTHPLPRRIPPVREEGPAEAGGSLPALAPRVLHELREESDGSQADSAQAHSEGTSPMEPAQPFAFPPLPAPPPNACANIDCECGSFSSVNDEEAASAIASSIPVPVYECIVKQWSKELPPEEAQRSDAASDGSLDRDKEDETITSEQVASLLAAVQNPCTAAPIGARERRRPLDKTKRRKGIYITTASDDGGDEEPTSSVNGCKRESSDASLQEMRLSAEARTSSLLGDKSDDSCTNGPPSPAESTTPLWPRSEELRARRARFSQQSSDEREEDNYRVRRKYGVTSRGDSPSEAESDTCSRDRTASPSPFSPSDTSDVEAKRQHLTRGPFGRNLEAPSNRSAEAGRRSFSDATVPCRKISAGAAPTCASRPRGPTHVRATSSPSKLAGVKPGADLLAELLRGSSEALSNSSTFDNVILTLHQHNVSRFLHYVSPSNTASFAQSNKVEKLRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9N3</accession>
    <name>A0A194R9N3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9N3"/>
    <dbReference type="STRING" id="76193.A0A194R9N3"/>
    <dbReference type="KEGG" id="pmac:106711453"/>
    <dbReference type="InParanoid" id="A0A194R9N3"/>
    <dbReference type="OrthoDB" id="7967436at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="328" mass="36304" checksum="EE071290879C9F97" modified="2016-10-05" version="1">MGATGKFMVVALLSCGITAVVSTAYVILCCLALIFRFDCSIGQTILQNSDYLLISIYKQYIQDESCGTFLSIDDLTDSKSVFVLTTVSLAVSAASVVATLSLTIAVLSRGCWYYLDFSAYVHTGLCLAMLVVDITFAVHFGSDYTSLTDKLNANTVMAPTNYMIDTLRIGAFFLMVLTMKGFVAHAVNLVLLVLLIYYLHSKNAEERQQHSIHSRGLLNAFEQPSYNEPWALQQGWTSTLGSGGNVHPDYMYNEGPPRSSNWEFMQGSRFPRQDSQPRVGTMPPRPFSYSEDPGLTPAMLRPTPPKPYTPNPDYSPNPRLKSALKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAC5</accession>
    <name>A0A194RAC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavesin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAC5"/>
    <dbReference type="KEGG" id="pmac:106711460"/>
    <dbReference type="InParanoid" id="A0A194RAC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF234">
        <property type="entry name" value="SD01558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="107"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="34006" checksum="02B2D8091D1BBDFB" modified="2016-10-05" version="1">MPFIDIAFAAEVSRFEDPEFEEHARRNCNEDPRTRQYAIEELRNMVYERGECHPRRMDDAYLLRFLRCRRFIPALAHKLMVRYEEFRRKNSYLYDCSAFGLQKVKHVYGGTLPESPVNGRITLMRFGKWDTEAVPIVDVVRCALIMDEIAVMQPKLQILGVTIIVDLEGLSVRHVRHLTPTIAGQIVSLMGVNFPLLMHGLHIINYNWFLNTFFYVFKQFIPSAAWGRMHFHGYDMSSLHKHIDPSSLPPEYGGTCRHVISTEEWLRKVNMYKDDFMVQELRDLGFTVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBU8</accession>
    <name>A0A194RBU8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phospholipid-transporting ATPase VD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBU8"/>
    <dbReference type="STRING" id="76193.A0A194RBU8"/>
    <dbReference type="InParanoid" id="A0A194RBU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="271" mass="30297" checksum="11C0D5C953292D39" modified="2016-10-05" version="1">MSTEGSGETPSTVPSLPGAPEQTYLFPKAKGHSRSVSHGGTPTLGGTLAARPPLKSAMRGHQRALSHGQIGEGGRTAPSSGHSRTGSRTDFILPPGHREPVPVSAQPRINSLRAHHSRQASRSDSIYTIRRDSVVAPWRRAVFWLMRRQQPAVDNRHLSVTPNHLVPEKTPPKDHPNGQRCDNKIRTTKYTLLSFIPKNLFEQFHRIANVYFIFIVLLNWVPAINAFGKEVAMLPVLFVLGVTAIKDLFEDRRRHLSDKRINNSFCRVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCK4</accession>
    <name>A0A194RCK4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCK4"/>
    <dbReference type="InParanoid" id="A0A194RCK4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="142" mass="15647" checksum="6C803AFAC84D19C9" modified="2016-10-05" version="1">MKVVVFQRRPRERSPTYATPLMSPYNARLESSSTGSSFPADSPKPVPLAVKANEHAKGARARGYTHTRARHHDDDIAFALSNTGVYFSVCFCIAPTIIGPELGDDTTTGLVSHNSLFWRPVWCAPMGALSLLWIIIRNMSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCT4</accession>
    <name>A0A194RCT4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-like subfamily B member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCT4"/>
    <dbReference type="FunCoup" id="A0A194RCT4">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCT4"/>
    <dbReference type="InParanoid" id="A0A194RCT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000021">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="43199" checksum="8A30EC2ECFF44B24" modified="2016-10-05" version="1">MVDYYRTLGVSKTASEAEIKKAYRKLALKWHPDKNPDNADEANRRFKEISEAYEVLSDERKRRVYDQYGKEGLNNGRGRRSAPDEDYEFGYHSFPFTFRDPEEVFREFFGGSPFGDLFADLNGHGYHHRHGRRSHPSTSLTSSLFSPFGLGLQGLDDAFAHAAFNGNAFTSFSTFNSSLAGPGSANMKSTTTTTRIVNGKKITTKKITENGRETVMSYENGVLKSKTVNGVPQSLTYNPTKTLGFVIVLTCIYIIICMLYVYGAYKCNNILMMPYIVVELVRLIALTVLIITLLLTLKKNTMDIGLLIGASVLGVGMFYLWVCAANLPIVINEKEHDEYVATITKLEELLQEKKPRTLIGFDYVPWSNYNEAIYNQNIHRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REB8</accession>
    <name>A0A194REB8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REB8"/>
    <dbReference type="InParanoid" id="A0A194REB8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="13345" checksum="61CF2C7C2CC9EB17" modified="2016-10-05" version="1">MLIKSRHLRVARKKRAHRKTLPVWIPHVTTEGHLSLKGKVEVNRCEYPGWRRRAAGLTSRAVHTAERHALRPRVLSARRQTIFGAKNPGLGSARRVARTPVVTLAPAQAQLFLQLSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REQ2</accession>
    <name>A0A194REQ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">RR48_09693</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Ya'a_city_454_Pm</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REQ2"/>
    <dbReference type="FunCoup" id="A0A194REQ2">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REQ2"/>
    <dbReference type="KEGG" id="pmac:106710061"/>
    <dbReference type="InParanoid" id="A0A194REQ2"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KPJ15770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="38282" checksum="794C2D0C121A9554" modified="2016-10-05" version="1">MYEPTLRYEKIDFLGEGQFATVYKAKDVKSDKIVAVKKIKIGSRLEAQDGINRTALREIKLLQELQHINLIGLLDVFGQKSNVSLVFDFMDTDLEIIVKDSNIVLTPANVKAYTIMTLKGLEYLHQNWILHRDLKPNNLLINREGILKIGDFGLAKAFGSPTRINTHQVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELLLRVPFLPGESDLDQLSRIFQVFGTPNEETWPGMKNLTDYVQFKQFPAQQLRHIFSAAADDLLQLLDRLLALYPPARCDCTQALQMPYFSNKPAPTVGAKLPMPTNISKMESEKPSLKRKLLDNIDGGSLAKRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RET6</accession>
    <name>A0A194RET6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RET6"/>
    <dbReference type="STRING" id="76193.A0A194RET6"/>
    <dbReference type="KEGG" id="pmac:106709942"/>
    <dbReference type="InParanoid" id="A0A194RET6"/>
    <dbReference type="OMA" id="MEQRDKT"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="251" mass="29445" checksum="96B6731C7913AB53" modified="2016-10-05" version="1">MTLLKLRSAPVVLIEDDYNINILPLVTSLVEDKLKINLFSYEQSIKLWEKVFQNQAVEYYQEFDPESYIECIKQPCHVFIDSVTQMSMHMGWHKCLTYIRKLKSHENVVKLILVLHKDCIQMHSKLQKHLMHLAHATITYSENNPFQIAVQIKLGNKFVKTEELLSYDNITSMLKCERITKEVIKDEEPAKPNPGNLTTFKIEVDQTQQLEKHNLKLPYMSKINEGKSKVYYEPDAVDDWDEEDPDEDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFH4</accession>
    <name>A0A194RFH4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFH4"/>
    <dbReference type="FunCoup" id="A0A194RFH4">
        <property type="interactions" value="1082"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFH4"/>
    <dbReference type="InParanoid" id="A0A194RFH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 8" id="KW-0186">Copper</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="16774" checksum="3F1EDB8302ACB715" modified="2016-10-05" version="1">MPTKAVCVLNGDVKGTVFFTQENDKAPVVVTGENDKAPVVVTGEVSGLAKGKHGFHVHEFGDNTNGCTSAGAHFNPNKQEHGAPNAAVRHVGDLGNIEATADGGVTKVCIQDSQISLCGPNSIIGRTLVVHADPDDLGIGGHELSKTTGNAGARIACGVIGLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGB8</accession>
    <name>A0A194RGB8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic dynein 2 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGB8"/>
    <dbReference type="InParanoid" id="A0A194RGB8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF15">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="141"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="934"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1346" mass="155321" checksum="47759A5F2AAF3EC7" modified="2016-10-05" version="1">MTKIRDFIISTAESFYDVSDLKINDKAEDALYDFLHNSQTYLLQTELNKEVLNLTTQIQCDIQKSIIFYKTSPVNLSKQESINNINIITITTGAAESLYQILRQIFSPLLSLGDDLYTNKLQKNLTDLETNLRILTHGKNNANINVILSIEDEVDYWRAMADKREATKKEREAASNYCVLFEDICEEIKSMQASPVYEIRDNAENVGGILDDIWRCTISPYAQHRMIHVFDIIGHIICSVTQKILSGVDLWKVHNSTKDDEVLKLINDSLNVTQTWISACLSLTDTYWPNYALHAWSGKSYVPQFCLNFQKRVKEIHDLRSIHNQLNKLLTNKERSDLKTDELFEPFTNINIWICNGKNPAWENAVLRFSSNLRPSEAKIAEKLRPRLHNTSTKQMLYEFMRYKSLINRPIVKQALSGELEIFVSSLASLVQGVRDQLEADDLHLNMYQPPEMSPLVQQIQWAKQMEAKIKDIQMCNENYLKEFQGSEEVSRLAEKVLKDIKNFYTQLHEEWSRDIQAQVKSGSLQLCTEKPVVEFSEQSRLLEVKFNPRLVWTELEARSLAALGLPAPGAALAIDALAHSLRYARDLQQVASFHNTLGERMIPSTRPMMLQAALDLAALVQDHSPVYWNDIEQLSDYTEKLKKMVLKLETQNSYLTSQHIAIRNIVEKLMDTELLVKQADWKKNIKHIRDIIEKVESEGYKNSEQWRSHWDWQLYKALECQYINTLLSLHTHFPHVRVDLVLRGRMVVTQPGLEEVRVQHYHQLRRLVSLPAHFLGLSTALDNKQSIFASIVDKHSWLGNKAVQQLEGVLGELLSTCEEWTRRLALACVPDLDALCADTLLLPKHWETNFKACKAYGQAVAKMTFEDEKISWMTVGTATLRREFEAQTRNLWSCLMSSLQTSCRHDTAELDAFIANATLMLENKSLPKNAKELAEINVKQQALQEKLPQLEKMVENLKRKGHMLRTWGGDQFVDHTVKEWKKVREQMLAQQQMFQHQAEIVKSSLKGEWENLNTSVETWVSRWMQARSRLQSVQGADYTEMLDRCHSVFEAQQQWEKYLSERDELMKECQKFNMDVTTSDTWNEAERLMKEFVDQWTVFKEYNEEYESIGEQEWLVFQKKLHFLDEFCSKWSARLEPYTSVTLFLKHTLDRYNDLTIALKYLRGSVFTEHHWREVFSLLDIEYRSPDILKLKDLLNAADNIKKQIKALQKISTSASNESAVRSALNELEVWFAGARLALAIHMDKANRPVTIVKHFNDILNKIEEKQWVVSSVGGGGGEACARWETRLRAARDLLRSAHRAQRSCRFINLVKGMKSVDRECFIMNGCAGGRVSAAVVGIAAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGH3</accession>
    <name>A0A194RGH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGH3"/>
    <dbReference type="FunCoup" id="A0A194RGH3">
        <property type="interactions" value="1817"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGH3"/>
    <dbReference type="InParanoid" id="A0A194RGH3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="507" mass="58725" checksum="37EBA742A35E40A7" modified="2016-10-05" version="1">MINQIIVLLTTFKLFFIPLYHSTDFEVHRNWLAITHNLTIDQWYYESTSEWTLDYPPFFAWLEYGLSHIAKLFDPEIGKYLWAAFWFSVLLNLKHIFLYIAPVYVVYLLRAYCFTVTSTDGVHTAWYSFSSRNLLKLAFIVITVFTISFGPFIQHIPQILSRLFPFKRGLCHAYWAPNFWALYNFGDKVLQYVLPIFGISVSSSEASMTGGLVQEYDHVILSRLFPFKRGLCHAYWAPNFWALYNFGDKVLQYVLPIFGISVSSSEASMTGGLVQEYDHVVLPSITPTVTFILTLLSMVPALIKLWNLCADKKYRAMSFIRCITVCATCSFMFGWHVHEKAILMILIPISFLAVLGDVDGRLFLFLSTVGNYSLFPLLYPKSLIGIKLFLLLTHCAIAFGNLPALYVVPKVKGTKRIRKLRLPMLSRIECLYIYNLIGLWVYENAIHFILGLDKRLPFLPLMFTSVYCALGVLYFWIRYYYYFLTFNLSMVPIQSVESTPQHNKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHZ7</accession>
    <name>A0A194RHZ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gastrula zinc finger protein xFG20-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHZ7"/>
    <dbReference type="InParanoid" id="A0A194RHZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="280"/>
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            <end position="364"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ17059.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="69670" checksum="3AA048DE2AB62BC7" modified="2016-10-05" version="1">MEIKIEVEVDTNELENDVSHDTRKEINKPNTITNDEGKKYAHCHVCDKNISFGSWKRHIRAHIGEKRYSCHTCGLAFNDSGNLARHSKAIHAKHRPFSCPVCDKTFSRNAHLLDHMKSHSESRDFVCDICGKASKSSAALRMHRKIHQEDCKYSCIKCGAKFKRSGELRAHVTVHTGEKAHSCSCGKSFRLRKFVGLSVGSNQYIEGSDNRKICEYCGIKQSEEDYPEHLISMHSEDLLPFRERDPFLYVISDDDDEYEEEKPVRKPRQTKLLEKFKTTEPAKQVTNAEPGEKTEKPNLAENANKTETAKKTKNSEPAKKPTEKKKRQTNNDKTCTPKPRNKKETTQKRTRRPRSSQVSKQQISDAVSIAIKDLQENQRDKELALSEVSEDLDAPLEINGPSKHVDNIEIFMESVDKLKVKRKIRPRRCKYCPRVFTASSSYSYHVKNSHQFEEMECDMCNKKFRNKQVLTQHITAVHEGKKKSFECKYCLKTFCTRANLYSHEQIHLDTKKWPCSECSRSFRWRTHLLRHMKRHSEDRLLVCQTCGRRFNVLDDLRRHQNTHTIHHYTCSHCGHRFSQLRYLRVHLMKKHNEHIPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIK5</accession>
    <name>A0A194RIK5_PAPMA</name>
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        <recommendedName>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26923" checksum="84CD0CAEC87347D6" modified="2016-10-05" version="1">MPWSRPSSVPVGKVWCRFKGRDKNGQPGKMYQIRDMELSDRKRCLDMMEETFLNDEPLCQILDIKSDIESVTTIRNNWESYADQGICIACYTEKDGMPQELVGFNILVVKTIDDNEEDIDNVAGEAWRKLLKTLVSAENLVDIFEYYGVDKYLTSSGLTVLPAYRGQNIGAKIIAAREAICSTFDIKAAATVFTARSSQVLAAKCGYQQLAVLPYERMLLQGIDLTGCDTPTAILMARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIQ0</accession>
    <name>A0A194RIQ0_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">GTPase-activating protein CdGAPr</fullName>
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        <name evidence="5" type="ORF">RR48_08623</name>
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        <name type="scientific">Papilio machaon</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIQ0"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF10">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN CDGAPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="417"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="617"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="800"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1343"/>
        </location>
    </feature>
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        <location>
            <begin position="1597"/>
            <end position="1633"/>
        </location>
    </feature>
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        <location>
            <begin position="1742"/>
            <end position="1791"/>
        </location>
    </feature>
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        <location>
            <begin position="1655"/>
            <end position="1682"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
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            <begin position="931"/>
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        </location>
    </feature>
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            <begin position="1196"/>
            <end position="1205"/>
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        </location>
    </feature>
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            <begin position="1294"/>
            <end position="1313"/>
        </location>
    </feature>
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        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1597"/>
            <end position="1608"/>
        </location>
    </feature>
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        <location>
            <begin position="1609"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1742"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1765"/>
            <end position="1784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1806" mass="200510" checksum="6BFC7D21CB4374A5" modified="2016-10-05" version="1">MRRVFGVCSDGWVLCGQNGSPHGSVMSCQSLAARAFAEPDKDPAQCGAFHRSVRFSSESRSSTRVSNDTDKRDTSGGMSVSALGVAPLPAAIAMSQSAPPPSISFDLHDESPPPVPSCRFPKLEECAHFHYERVSLGGLSIQTVPCEEQCEDNDPSEGWICLRVRSHVSGGEQESGGGAGAAAGAGEPHSWSEPAGLSEWTLTRSRDNFLQLDDMLHRCIYDRKVSGLPNLSEEVGAGCEETRYQQLIGDYVHHLSIIADDSINCGPVLNWLQMDNKGHKLLVANEDSSSINTPAVAAAYSVRKYVSQSSVWCMTYCSIAAEVLVLSGPQESVWWRGKRGFRVGFFPRHCVAVIGDKVPRHMTQPPPIVGSVAVAPIKPVLRKHGKLISLFRSFILSRPSRRSLKQQGILKERVFGCDLGEHLLNCGHDVPQVLAECARAIERRGAVDGIYRLSGGAALTQRLRAAFDAAGDTPPDLAPPLQRDPHALASLLKMYFRELPNPLCTYQLYESFCSAVQQPDDAARLRAMTDTVVKLPPPHYRTLSYLMRHLRRVSLLSAATGMTARNMAIVWAPNLLRSPAPQHALQGVAVQAVVTEFLICYAEDLFAQDQGSDSGPDSLEQCYVPQVLAECARAIERRGAVDGIYRLSGGAALTQRLRAAFDAAGDTPPDLAPPLQRDPHALASLLKMYFRELPNPLCTYQLYESFVSAVQQPDEAARLRAMRDTVVKLPPPHYRLTTALFRGPLSGALAPSHSMERPPKRPKSSVTSQSGNNNEVTARAEASEGAYYYLTRFRLSAICARPPPSPLRGTESCRRPKSLPLNPPTKLLSLEEARRRGLGAGAGPSAPPASGAIAAAAAAPLTSPAQDRQLRPAGHLKPKYIEVGSGPNNLPQYHTVLDLPLSGGKRGLKRSPSGWRGLFWRSKLQRARAPPQGPPPAPLPPPAQQVSADVVMSASLRPVKSCESLASDTDTLPPLADRASAPLKHHTRSSSCDSYFEPWQAELAHMRLRLSPQERDRHMFIAYLPTLKPNMTLAENGTRPGKVKPHLATAAFTIPYLSTLITPVSHGTAKKDLERNSPRKSKAASRYSGLHHPVLVDPDNTRLTWHGKDGHSTLIKIDWPLENSSVSNLTTSTINSSPLTPVTPLYDPLESDSELSDNKHTIQIKTVDCESCDREKCLKCELKATDYENMRLSHELSEGTLRDSTQHSPAHSAHSPHSLHSADISYHNLNRLSALSASSNSDHTDRRRDQDALKVMTSSHDSSSSYSNASLPRPTDDLYECFNFSRPNYINLQSSSTSKSSPGSPLKSPLKSTISITFRSPTKSKSSDYEPIDNIDTPTNDRDSVYEDIDLEKNLSIVEEAPVPETDASLPTQQACQPDCSEDLIILETPTDTTHIDENVDVYSQVKFFRKSIEEVNAMILESPEKDTHDKIAEEPNAMMLESPEAQRHYENVVFIESRDREYENINVDTLKICDKLDISEVNEHKSDPEQETLEFDNGNVIKQKTVSKNLNVRELAIRFESPTEQKGPFNFDKFKTEIKYPSLERKDDDKCESRKKEVTVKLPPPVSPKTYKLSKNSARSLDENAFVKEFGNETNDRRKSLEVKEASKQTNNLPDLNLNTEEAETKPDSITPTTENKISIVQRFELKKPDLRNLIDIETEKNLSRERIEKYKEERRNFLREKYSSQSFRSNPEQLTRIKIKKDPEERTEMCERLQDDLPKFERRNTVDLGQRMRFSLAKSSNNLDTIQSPESPIPDLDTTNLEFSRKEDNKRDVRREERKEKMSPSFNIRDMAALFEQKSHNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIW7</accession>
    <name>A0A194RIW7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIW7"/>
    <dbReference type="STRING" id="76193.A0A194RIW7"/>
    <dbReference type="InParanoid" id="A0A194RIW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265239" description="SAM domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="937"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112782" checksum="C2B19777BB4AED0D" modified="2016-10-05" version="1">MTGLLAMVTYMTGLLRELVALTGGVEGGPPYRMPPAPEAALPGAPAPPAPPAALHTHSAKFPIEREVILSSGEKNSKVPILQEARKRGRLGAVAHDTPPKTLSAWTHAENQQAGTSGDFRQYHDQNYSYAMHQNQNQGAVPRNIQNYDSPKPPIPAKNYGTKADLQNNSHHITVTVETGKDNTRDAPKSTKSVSKTYHTLKDMISSRFKGKDSNDNEKTEEPSLNNIEERKRPETEQVTPRETPTRKVEQGIYGRPMPQARPDMQYSHGMSNNMAYPSPSPHRQLMQQQQIVQQQMILNQQARSQEMLSSTPHSRPQALGADALYQQYGPPGRRSAVYQRDMDVRSMANFTSLKSGPQNQFDNSHSRLDLRSPQQLEREIVRQRGLVEGRRAASHPHLLDEPPQRPEVNTPQIHERSRRNSHGNLLDGLPVENSPQRNMTEERESDDGGFRLRLAAQGRSSFEERIRTSGRSIESNRQERLQENIYRRTPEGHRESRRTPDSLGNRHKEETNNHQGPERNDESASQKSADSVYNSSGKAETYHPQPSSSRHTPNRIEDLKAHGKKGANGSGASSDYDKNGGQSSNVDSGRGSVAYSSGRRPEASPHDTSVDSDAVAHPRNQPQPGTSQQQTVPNGENEWADLVECELRQILEPKLSALRLDSSASSDGSVTPPLPPLSPSSDLHKRNSLPGRSSEYPEERRRGRESPRWHGHKKHSSKRDHHYKKHLFGLDTTDVTSTTTRSLDLSSLLGARSDSDASGGDARAIRRQLRGLENMYAEVLQLLGVRRPAPAHASHGPHTPAWDARLSSKRRYGSMSSLPSSSVSSRPVRDKRRSSNDHRKKHDLKGINKRFQRLESHVVTLARSVAHLSSEMRTQHLVMQEMDNIRAEIAALRHMYKSQQFIRSGHQRHLDPYSFSNPDRVKRLTKLLGDEPPLMRLFLKKLGYEKYAALLEKEKVGAAELPYVGEDKLRSLGVPLGPRMRILKEAGIHQDLHARDDHNTTTTTLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJG2</accession>
    <name>A0A194RJG2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inward rectifier potassium channel 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_07176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJG2"/>
    <dbReference type="STRING" id="76193.A0A194RJG2"/>
    <dbReference type="KEGG" id="pmac:106707941"/>
    <dbReference type="InParanoid" id="A0A194RJG2"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF113">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="198"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ17692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="383" mass="43701" checksum="84C9BAB8BB55AB0F" modified="2016-10-05" version="1">MHKFEHGDNSSLNNTNDVKEIATLVPGVYRPISRTFSYCPKNLRHERAVLKTGEINVYRKQDSNFFSNCFLILVEARWRWTLFSFFLAFTTNWLLFGGIYWCISYAHGDFLEANLPQNVNSTEFTPCIENIYGFTSTFLFSVEIHTTVAYGRRAITLECPQTITAMCLQCIVSSAFQSVMIGILFAKLTRPLARTRTILFSKYSVITLRDGQLCLIFRVGDIRKSRILNIKPTAYLLKWDTDCDNLLNAEQIELKVETVECESVFFLWPVHVVHIIDEHSPFYNMSAADLLCCKIEILAVFEGIIESTGQSIQARASFTETDILWGHNFVPMVSYNDDKCKYNVDFSQLSVVEQVETPLCSANEYNSVVTAISSTFTFDSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKV3</accession>
    <name>A0A194RKV3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Silk gland factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKV3"/>
    <dbReference type="FunCoup" id="A0A194RKV3">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKV3"/>
    <dbReference type="KEGG" id="pmac:106721508"/>
    <dbReference type="InParanoid" id="A0A194RKV3"/>
    <dbReference type="OMA" id="STMASCM"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20041">
        <property type="entry name" value="FH_dFKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047388">
        <property type="entry name" value="FH-like_dFKH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013638">
        <property type="entry name" value="Fork-head_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08430">
        <property type="entry name" value="Forkhead_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="113"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="113"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="38563" checksum="7128A4F194C9FE4B" modified="2016-10-05" version="1">MISQKLSYGDVPTSASLSSLSPGLAPPYVNGMGCMPAQPYPNIYSNNMVAGGSCMASPGVGYSPPSTMASCMGGGGAVPYGALPREQEAASPTSALQRARNDKTYRRSYTHAKPPYSYISLITMAIQNNPSRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWTLHPDSGNMFENGCFLRRQKRFKDEKKESIRQAQKAAHTHGHHSSGHEKRDHGHEKAGGGAGEEKEMRDDLLAQLHAAPELCLPEHTPLALEHYAQLKQEPTGYAPAPHPFSITRLLPGADTKSDLKMYDVNYGYGHAPPDNYYQSPLYHHHAHAHAQPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLA2</accession>
    <name>A0A194RLA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetylcholine receptor subunit beta-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_10360</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLA2"/>
    <dbReference type="KEGG" id="pmac:106708975"/>
    <dbReference type="InParanoid" id="A0A194RLA2"/>
    <dbReference type="OMA" id="RWMMEIP"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19032">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000035">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000023">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251207" evidence="18">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="240"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ16761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="523" mass="59608" checksum="0C57CB61FE023B29" modified="2016-10-05" version="1">MRAGSRGPLLVAALLAILYSGWCSEDEERLVRDLFRGYNKLIRPVQNMTQKVDVRFGLAFVQLINVNEKNQIMKSNVWLRLVWMDYQLMWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPNGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNIYEGNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPLWIRSVFLHYLPTALLMRRPRKTRLRWMMEMPGMGAPPHAAAPHELPKHISAIGSKQSKMEAMELSDLHHPNCKINRAAGGGEVGALGGLGALGGLGLSERRESESSDSLLLSPEAAKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTIGILMDAPHIFEYVDQDRIIEIYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLH1</accession>
    <name>A0A194RLH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLH1"/>
    <dbReference type="KEGG" id="pmac:106708783"/>
    <dbReference type="InParanoid" id="A0A194RLH1"/>
    <dbReference type="OrthoDB" id="7488583at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007614">
        <property type="entry name" value="Retinin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931:SF3">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265281" evidence="1">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="352" mass="35555" checksum="6641707F519069F0" modified="2016-10-05" version="1">MKLLVVFSALAAVACASLIPLAQPSHYGAAFVTHAAIAPVVAPAVVAAPAAVSHQSRVDVRTSPAIVTAHSAYATPLLGHSALGFGHGHLLKKRSLGHVAYAAPVITHAAPVIAAVPAAVSHQSRVDVRTSPAIVTAHSAYATPLLGHSALGFGHGHLLKKRSLGHVAYAAPVVAHTAPVIATAPAAVSQHSRVDVVSSPAVVSHTITAPAVAHTFVAPVVARAAYAPVVAHAIAPAAVSHQSRVDVRTRPAVVSHSVVAAPILGAHSSLTLSGHGHLLKKRSLGHIITPVAVAHAPAAVSHQSRVDVVSRPAVVSHSVVSPVVSHAVPVVPLAHSASRLLHASPLVHGAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP56</accession>
    <name>A0A194RP56_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP56"/>
    <dbReference type="STRING" id="76193.A0A194RP56"/>
    <dbReference type="KEGG" id="pmac:106707800"/>
    <dbReference type="InParanoid" id="A0A194RP56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31562" checksum="ADDEE862A816AF0D" modified="2016-10-05" version="1">MGSRFEGVEQGPPIEVFQLNKLFIDDTFKNKVNLTIGAYRDENGKPWVLPVVRRTEKQMAEDESLLHEYLPVLGLDQFTSASVSMLLGEDNPVIAEGRAFGVQTLSGTGGLRVGAEFLNKHLKYTTFYYSNPTWENHHLVFMNSGFTQPRSYRYWNPETRAIDFDGLIADLKGAPENSVIILHACAHNPTGIDPTHEQWEKIADVMEERKLFPFFDNERVGNLAIVMSDAKHVAPCKSQLTWIVRGMYSNPPAHGARVVATALSNKHLFDQWQVLPCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPM9</accession>
    <name>A0A194RPM9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPM9"/>
    <dbReference type="FunCoup" id="A0A194RPM9">
        <property type="interactions" value="1636"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPM9"/>
    <dbReference type="KEGG" id="pmac:106713859"/>
    <dbReference type="InParanoid" id="A0A194RPM9"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="37715" checksum="8F522076A4D70CA9" modified="2016-10-05" version="1">MSDSGDSDITWTFYKDRPEWSDVTPVPENDGPKPVVVIAHSEKFEDVYDYFRAILQTNEKSERALHLTKDAVDLNPANYTVWQYRRDLLQALGTDLRSELDYVEAVIKQSPKNYQVWHHRRVLVEWLQDSDLELELTRDALLQDPKNYHAWQHRQWVIKTFGLFEKEMEFVDNLITEDVRNNSAWNQRYFVMNNHLGWSDINVQKEIRYTLEKINFVKNNESAWNYLRGVLLHDAKGLSGNTEVTSFCEELYSNKCRSPYLLAFLIDICDEAIKKGEINSLYNAEKALNLCQALATKYDKIRSKYWNFIAEKFRKYQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ37</accession>
    <name>A0A194RQ37_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4 14">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_11062</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 14"/>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ37"/>
    <dbReference type="FunCoup" id="A0A194RQ37">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQ37"/>
    <dbReference type="KEGG" id="pmac:106718346"/>
    <dbReference type="InParanoid" id="A0A194RQ37"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF69">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="16">
        <location>
            <begin position="169"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="276" mass="29360" checksum="BDEAFF78686F8F14" modified="2016-10-05" version="1">MSITIGFIGGGNMSTAIAKGILRNDSYSASQIWVSGPHTAHLKHWEEMGANVTDKNGEVLSKCDVVFLGVKPGVLSYAVSDCLKSLPSGGPRKNFFFVSMLAGIAIETLHEAFKVFDFPTSVIRIMPNTPMSVGAGICLYTPDDTIKPEQCMLLEKLLNSCGICEKVTETLMNSGSCLPGCGPAFMYIVIEALADGAVKQGVPRAMALRWASQVLVGSGEMVLQSKKHPGHLKDEVCSPGGSTICGVTALENGRIRATLISAIEAATLRTYEMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQC6</accession>
    <name>A0A194RQC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQC6"/>
    <dbReference type="InParanoid" id="A0A194RQC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15141" checksum="55D7290C0C4FFAAC" modified="2016-10-05" version="1">MDTMISVWTVVEHVRVASGAAELAIFTAILYWFFTSSRVADMLEVVGERVGGWCGRDSSTSLRQAVRARRRQHNDVYSKLDAEIASRTSALYRVKEGPVVPPPQPPSRPPAGLACARCAPLSRVYSEHCWGFYINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQY9</accession>
    <name>A0A194RQY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA mismatch repair protein Msh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQY9"/>
    <dbReference type="FunCoup" id="A0A194RQY9">
        <property type="interactions" value="1825"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQY9"/>
    <dbReference type="InParanoid" id="A0A194RQY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="719" mass="79792" checksum="E8B7E91C133307A8" modified="2016-10-05" version="1">MGLEPDKLDYLVLSKGNFEILIRKLLLVKRYRVEIYVSEGSTKNNEWRLEYKGSPGNLSQLEEVLGDGLGTANENAPCLMAVNFKTDAVTKGRLLGVACVTAADYQFSISEFTDDDLLTQLETITVQTAPAECLVIQGDNKDQKALKKVMQRANVTVTKLKRSDFSTEGLIQDLNRLLKFKNNQSQDANAFPETRKEVAMSSLAAAIRYTTLLNENTNFGRFHLTTITTAGFLHLDAAALTALNVFPELGDISHSPTRSIYGLLDRCRTQHGKRFHLTTITTAGFLHLDAAALTALNVFPELGDISHSPTRSEYLVKASFDEQLQSLRSELDRLQVAAERQLRAAADSLGLDPGKTIKLENNPQNGFYFRITNKEEHAIRGSKKFTIIDAVKGGVRFKNNSLENITDEYVQTKDTYEREQDKVVAEIVNIASGYSECLFNLSHMISRVDVLVSMSVAACSAPLPYCRPVITDSMEELLLSEVRHPCLEVQEGVSYIPNDVHFKRGKCVMHIITGANMGGKSTWMRSCGAAVLLAHAGTATPDSLVLIDELGRGTSTYEGCGIAWAIAEKLATESQCFCLFATHYHELTRLEAQHPGVIVNSHAQASVVDGQLLLLHRIQPGAAPHSLGLHVAKLADLPDYIIQYAEEKQSQLETNLFEIEASMKSQETSEGQEIILDFLRKCKQINESVTSDEEMMKEIDKLKRELQQHNSKYLQSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSG3</accession>
    <name>A0A194RSG3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pupal cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSG3"/>
    <dbReference type="STRING" id="76193.A0A194RSG3"/>
    <dbReference type="InParanoid" id="A0A194RSG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265401" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="15417" checksum="9E10FFA9D080EE4A" modified="2016-10-05" version="1">MQSMIILATALCVAQASFYAGAPAPIQLSPDGKYVLDTPEVAHAKAAHYAAHAQASTSQGAWAPAASYHGAPAYAAGAHYGAPGAAGYAAGYGKWTGPPANIQLTHDGQYVVDTPEVQHARAAHLSQYAAAAHAAASAPEEGPWNHGHGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RU31</accession>
    <name>A0A194RU31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RU31"/>
    <dbReference type="STRING" id="76193.A0A194RU31"/>
    <dbReference type="KEGG" id="pmac:106715562"/>
    <dbReference type="InParanoid" id="A0A194RU31"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF213">
        <property type="entry name" value="INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="36464" checksum="3A32495B009EE3C2" modified="2016-10-05" version="1">MYLNLSYNLLSELELGLFDEKPNLKLLDLRGNTIFLLKFGIFDLLKKIQHIDLSSNSLLGREINPYTFDSSKEIQFIDFSRNDMSESPDNLLHAFRALDFLNLDRCFLKEVPRFATIPNLKNLKHLMLSTNLISKIDNAAIFVNLDNLEILNLAENCLEYINEKSLKPLRNLKMIVLRDNKLKHISDDLFRNLPVLGIVDLSHNALTSVPVSMFKGTAIKNLNLSHNKITYLEYNFCLELKNIGGKLSKFFFNQNPWQCSCLRELLREVKALNVGYNSVMYNGEHPVCVTDVEFVCHRDENYNDVYVKMFENLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A068PW36</accession>
    <name>A0A068PW36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Opsin-2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">UV-sensitive opsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PmUV</name>
        <name evidence="20" type="ORF">RR48_07605</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Unique regionalization and distribution of duplicated opsins in the eye of the Common Blue Bottle, Graphium sarpedon.</title>
            <authorList>
                <person name="Awata H."/>
                <person name="Matsushita A."/>
                <person name="Arikawa K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="19">Eye</tissue>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May play a role in photoperiodic photoreception.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AB725231">
        <property type="protein sequence ID" value="BAP11288.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001303951.1">
        <property type="nucleotide sequence ID" value="NM_001317022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A068PW36"/>
    <dbReference type="FunCoup" id="A0A068PW36">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A068PW36"/>
    <dbReference type="GeneID" id="106719192"/>
    <dbReference type="OMA" id="PACACKF"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="76"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAP11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ07189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="380" mass="41625" checksum="436C9D015E4F7BD4" modified="2014-10-01" version="1">MIPAAVMDNHTENNYNYGAYFAPYRSEGVELLGAGLTGEDLAAIPEHWLSYPAPPASAHTMLALVYVFFTAAALIGNGLVIFIFSASKSLRTPSNLLVVQLAVLDFLMMLKAPIFIYNSIKRGFASGVIGCQIFAFMGSVSGTAAGLTNACIAYDRHSTITRPLDGRLSRGKVLLMMVCVWLYTAPWAILPQLQIWGRYVPEGFLTSCTFDYLTTTFDNKLFVASMFVCVYIFPMMAILYFYSGIVKQVFAHEAALREQAKKMNVDSLRSNQNAAAESAEIRIAKAALTVCFLYVASWTPYGVMSLIGAFGDQNLLTPGVTMIPALACKGVACIDPWVYAISHPKYRQELQKRMPWLQINEPDDNASNTTSNTANSSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB43</accession>
    <name>A0A0N0PB43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB43"/>
    <dbReference type="InParanoid" id="A0A0N0PB43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="701"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126051" checksum="FB9569883A9F3C42" modified="2015-12-09" version="1">MDDTEKLTPQTTDHKASNVLPDVVHSQQIPNMSTVENDESETALDTGQSAEGGKSQHIEDEGETESISEHVPSEIEYSVTESGDVNAGQTSDDLLNVDKGKTSDNSANVPIPHSNNSNIEDPSKLSWNIDVDNNAHISKESPVNLTMSLDSKGILTKSLSLRSDNNEQKELENEGSIKSDHPDQQLDDQKDEVDSPKESLCSEYVDSLNEDVSENSYSSNDNNISNTSKHSEHSAEKTPRDSSESEEIIKLDIRGHGLPKFPMQAAKIIFGPPPEGSTVIESQITPIPAFQNLLSPFLVVGNEGVKVEEIYDEVGQKSQQLSPEKSPMESLSSDKTEKDLLVEEMTVENVKVKDEESPRQLKSMPVEETVSLSTITTDYKTICEEYQEKLVYFEDAMTSRDELIAELTVSLQRSVQERDQLKHDNHHLMNELQHLQHVTAETPLSEHDTVKAQLSDFIKYQSMVKDDSTKFYSAVMSGTTSLQSSNGEKDIDREEITVNYSKSDLRSSDTDEFENGFEFKVVTLLNKFEEYIEENLRNKLRESIIQVLCDEIGKMRIDFDTEMKEMEAQLQQDKQSYSIETRRLRELLACVKAGNADIDALREELSIKHEKEMENLRTYFEKKCSDMERSYSEEVWRGRVCVSPPSGAASDYSEEVWRGRVCVSPPSGAASECADAAAGDCRRRTRSADFPSLTFESTPMEQLMKQLHKKYEQQMEEMRAENAAHVRELRDKHAERVAAMEEQINQLKAHIQTAENTEGNVSIYQQDIDLELEKDAEESRREEVRQEVVDQIQEQIKVLLSDPDAELSSWPLELVALRDRIHGDARALHDKEVPSLREEAPSAAEADKWRQRRYNSFDQNRQLEEVTKERSFVEECGRVSVGGVSLDSSSSELDVSAVQRHVHFAPELGGVLAALDEAGAAGFLQHQRDLSADIKRELEHSLRRLRHEAHELLDLSARLAANKRNPETRMLESSQVEIKELEDEPEEKQKSCDNCELHKKTMEEAMSECLQREGLLRADLDAAMVKIAHLMTDRAPSDDVIAEGYGTCSALERRACAGGTRSLEEASPRSQLHVLARDLDLVQRDRDDLQQQVTHSALTPTPHLHSPLLHTPHLHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBD8</accession>
    <name>A0A0N0PBD8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial intermediate peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460968">
        <property type="protein sequence ID" value="KPJ10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBD8"/>
    <dbReference type="FunCoup" id="A0A0N0PBD8">
        <property type="interactions" value="1282"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBD8"/>
    <dbReference type="InParanoid" id="A0A0N0PBD8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="7">
        <location>
            <begin position="234"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="7">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="547" mass="61668" checksum="F03907AA8BE6E5CF" modified="2015-12-09" version="1">MKLFKPISVLRHGRKRRVSRGVSTWSPLATAFNTRPNSQPIFDTLRERTGLFNKPELTSFEGFYTLKDQAIASTDRLIEEAISGPTRPMVEVFDELSDTLCKVADLAEFVRIAHPQPHFASAAEDACISISGVVEKLNTHKGLYEALRDSVRRGTSGDQHLAELFLFDFEQSGIQLEDEPRKRVVALNDLILQTGQRFMAGAAKPRRVPRSAVPQNVRQFFSSEGDSVIVSGVYAECGEAAAREAAYRLYLAPEPSQDRLLHTTLTARHEMATICGFQSYADRAIKASIMENAANVREFLDILSDNLYDRAKMDFDTMLSMKKKETPYQDSLMCWDTPYYTHKAKTQLLNVANSDFSPYFSLGGCMEGLNMLCQELYGITLKSEEMLPGESWSPDVYKLAVVHESEGLLGYIYCDLYERPGKPHQDCHFTIQGGKLLPDGTYQCKLTINMFAGESWSPDVYKLAVVHESEGLLGYIYCDLYERPGKPHQDCHFTIQGGKLLPDGTYQKLLRDYLGMEITPKALATALTDELDHHKDNLDRVFRISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBE4</accession>
    <name>A0A0N0PBE4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="KQ460954">
        <property type="protein sequence ID" value="KPJ10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBE4"/>
    <dbReference type="FunCoup" id="A0A0N0PBE4">
        <property type="interactions" value="1779"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBE4"/>
    <dbReference type="InParanoid" id="A0A0N0PBE4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="200"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="629" mass="70820" checksum="E9108AE10F534200" modified="2015-12-09" version="1">MSSGNYWKGAPLSMLYGSESPWDNPGFPPVQPGHNHAVLYHIPSNGVLAGDRPPKPQVGQDKWDQHHVRLPCSKHSLYPVTDDKGETRLRKRWAIIVDTLKKPIRNSHELANAILAYNTKFKNRWKFRALHKLFNECLEEEESQSFFDVTLPEIVKLVLDLPKLIQAPIPLLKHLAVCCSAVPCGVVTYSRRSVPPRALPRWRDSTKTLALPLHLNPIDTIEDADGLIQVDFANKYLGGGVLGHGCVQEEIRFVICPELMVSMLFTEVLRPNEAVMIIGGERYSRYGGYGHTFEWAGPWAERAPRDCSGRRRQALLAIDALLYHSSRQEFRHEAITRELNKAWVGFSFYTSDDTSDMQYPGVATGNWGCGAFGGSAHLKSLLQLMACAQAQRPMAYYTFRDNKLADDIHAIYTQLVNYNVTVGQLYQMLVDFCEEGLPPSRLHHYILQHITGASDTPTSTTSTTPTTTPTATPTATPTTTPTTTDSTESEIRDDIHMSDSVITECFNSPFVFHTNTQEKCSLSEQQVDAKKNFEERNQTSRDDKMETDDKMESDNKMAASDSNDMTSRLFQEMEKLDEGNGSLNFSRPHTMPLSHNSQSDSKRSSMDLSMDVKKKISKKITDYFSKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBW2</accession>
    <name>A0A0N0PBW2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine-rich motor neuron 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460784">
        <property type="protein sequence ID" value="KPJ12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBW2"/>
    <dbReference type="FunCoup" id="A0A0N0PBW2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBW2"/>
    <dbReference type="InParanoid" id="A0A0N0PBW2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF3">
        <property type="entry name" value="TENECTIN ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="696"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="836"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119485" checksum="8AC27F038FE2F4E6" modified="2015-12-09" version="1">MAAMCHYEGRHYAEGAVVPVRAPCLRCRCGRGAISCRRRTCTAPPAPAEPCQSERSRDACCPHLHCSDFTDIMERVPDIITKYEEVYSEVVKSHTHEHPVCEEEGTVYAAGSAMGSATACEQCFCLGGARRCVRPQCLRPPLGCRARPAPGVCCPQRYYCEHPTTKPPDEHHLHDCQVEGQWVAEGERVEARDGAACSQCFCLRGAVRCQALACAPPLLGCRPLLEAGQCCPHQYQCVFQQRQGLPDFHTQPILDNTLSSFQNKDRSFRSAPPIEQYNVTKALSITVTDKTTTSLMGDEHDSTATTKVKRKTSDSSTQTTSKSTEGLTTATATAQTTTKVIVSTDRTTSQATEASTPEEDATEQPESSVKIIINGTINCTAELSTTTVTINSTKANETENYSDVENIQARIPNIAQSFESHTYNPNDIITDRNYNEDFDENESYIINVTSSLISSLRTNNTLSSPAPSATKVTNTEAADTSSIQNSSKKTKDEYEYYYNKPTLPPSLPNLKIIPFVAADAVVDDDTSSKKSHAYPIVDRHDKYPVYYPSGEGKDDPFATRREDLYNPTQFPIFLSKNIESAQYPLSAHEVHLTNEYPSNGDIITSVHEYSVTTALGSDLTQANKATTKLPGHNTKFELDTPVVNLFSPPVETEGGFIPKDPAIIDDFYALYTSSTPAGANVPHLTTSMQLDTTKECVSEDGQRVVEGEAISLACSVCTCAWGELQCSARPCDSPPGCRRRPTSASSQDLCCGDLICNSGNKTTPFPQFLSTRSVPVILLVNKSQEISANSSDVFTELSIVDNTTLQSYTPTTAPPKIITTMSSTVVNEERFKSEVTNINLEQSSTEKNEQSSKPTTVAVDSEKDNDNSQEYDDDSDDDGFSLGSVLKLLLSDSYATTTAAPVKQSTVPVTHITNIVTKTTQAPKTTTKRQPFKSSSPLASVTNRPPYMPVKHHQPQSAVNRIDHLILGESTAIKKMTPRPATVPFKPIPTRKPAPAKMSTSEKPFITTKPVEVTKKTDYVQYTSITQDNVRPSTSNHLSGGLGPGFLKLAGCNIYGKMYRVERIIAELSSSCQECRCTELGVQCRQLGCSNTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBX0</accession>
    <name>A0A0N0PBX0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADAM 17-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460770">
        <property type="protein sequence ID" value="KPJ12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBX0"/>
    <dbReference type="FunCoup" id="A0A0N0PBX0">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBX0"/>
    <dbReference type="InParanoid" id="A0A0N0PBX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000017">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="250"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="482" mass="55581" checksum="DF831582B3A5CB67" modified="2015-12-09" version="1">MRLAVLEIPSNKHVSTHPNSPIFIISSLSNNLKYYETLHSSSFNHHIVKRGTKQSNHPFNTIKELHFRTLGKDFRLILHPHSTVLHSNFKAYAVDGEGKKTVVHVDRDNFYTGRVFGEKLSDVKLHIDNGVVTGIIRTPDETYHPSWRHLPDQEDGTMITYRSSDIHFSWMHNNGSRPRVCGYVKEGQELEDDDEDYNHDVETKHEQLEKNKYLKISQQTDHHNNVPYEDGTDNKRVKRQSDYEYTPTKTRCPLLLVADYRFFQEMGASNTKTTISYLISLIDRVHKIYNDTVWQDRQDLDGFKGMGFVIKKILVHSEPTRVRGGEAHYNMVREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDVVECSPTASQGGSYLMYTYSVSGYDVNNKVIVIPPTFYIVCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBY4</accession>
    <name>A0A0N0PBY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transcription factor HNF-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBY4"/>
    <dbReference type="STRING" id="76193.A0A0N0PBY4"/>
    <dbReference type="KEGG" id="pmac:106713643"/>
    <dbReference type="InParanoid" id="A0A0N0PBY4"/>
    <dbReference type="OrthoDB" id="8183030at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06931">
        <property type="entry name" value="NR_LBD_HNF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000026">
        <property type="entry name" value="Hepatocyte nuclear factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000012">
        <property type="entry name" value="Hepatocyte nuclear factor 4, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049635">
        <property type="entry name" value="HNF4_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="178"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="490" mass="54338" checksum="E1ED01D8464909AF" modified="2015-12-09" version="1">MPVFPCDIATSHDLCGMEYTPEYMLAGPLHVWDKPPYSPYGMFNRTSAEESQRLTTLECVYKEDSDMQLETSSSEASAASSTTLSQHCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHLYTCRFSRNCVVNKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRINCRRPSYEEPAQANGLSVVSLLNAELLSRKVIDETNNVTDAEINNRNLAKINDVCDSIKQQLLILVEWAKYIPAFTELQLDDQVALLRAHAGEHLLLGCARRSLHLKDVLLLGNNCIIAKHNIDGRMDIDISMIGMRVMDEIVKPLREVDIDDTEFACLKAIVFFDPNAKGLSQPHKIKQLRYQVQINLEDYISDRQYEGRGRFGELLLCLPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGASTEPAMLEEAVSGGVSGGVSGGVSGGVSGGVSGGGASPALVPQLPAHQYDVIAFKQEPDMSPEPSSRMMKSSDITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC10</accession>
    <name>A0A0N0PC10_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin-XV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03066</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N0PC10">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC10"/>
    <dbReference type="InParanoid" id="A0A0N0PC10"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000005">
        <property type="entry name" value="unconventional myosin-IXa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="202"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="942"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1619"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1724"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1950"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2077"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="838"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1619"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1661"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1738"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1767"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1800"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1813"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1852"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1893"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1950"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1980"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2077"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2319" mass="256638" checksum="30C526F4B61A8A5C" modified="2015-12-09" version="1">MAGSGGSGQLEWAEGAAVWFQPPGAPAPLPGDLLEVHRAARVLLVSALVNGQSMRVHFAPTPSSSPDICEACNLSCSSTDSQNSTWTRHNLFHKRKIRQKARMLPKSPILKTSKNKMADVRHRKWRSMSVRKLKELCLEVMLNYLRHVTVAAGDDSFPSGCGFVLFLDYVTAFINPQTFALQMGNGEEEGDPVWPREELGPTGVEDMTRLHDLHEAALLWNLKLRYEQGLIYTYAGSILVAVNPYRPVDSLYGLQTARRYHAAEALGDLPPHLFAIAAAARSSLPHPQAILISGESGAGKTESTKLAVQFLAAVAPAPLGRAPVSEQILEAAPLLEAFGNARTPKNHNSSRFGKLLELYFKDGALAGARVAHYLLEKSRIVTQSPGERNYHVFYELLAGLDEEQRRTRGLLTAEHYFYLNQGGDSGGAGAGADWSALCGAMQVLGIGDAEREDIIRVLAAVLHLGNVYFHRRQLHHGQEGVQLGGGAEVRWAAHLLKVPAEALARALTTRVTAARAERMRSPLPIDQALDARDAFAKALYSSLFNWLVLRINSIVHRSGLHDAHRISLLDIFGFEDLEENSFEQLCINYANETLQHYFNKHIFKLEQQEYQKERLEWSNLTWNDNSPVIQLLSKKPVGILHLLDDESNFPRASDASFLEKCHYNHALNELYSRPRLGANEFGIKHYAGQVWYNVEGFLDKNRDALRGDVLELLCSSDVPLVAEMSGQLRAQHDNNKTLPRGANGRFVTMKPRTPTVAARDNYILKRGFWSQKATVTGADYQLGAARVFVREALHRALERARADKLRAAATTLQAHIRGYLTRNFFILCAFFLFRADGVAALEEQRDAQRRRQEAQQAAAKRRAAEQKAKAESLQVLEVPAELAFILTKVDEMPPPHTEKNITKVSGDVFAEEERIQLPKDLHQFAFSKFSSVYFADGGQLSPKKQPITKPFLSKAAVRDQDFNDAIAIFKLILRWCDESAAGDDTRQKVLADYIASRGIASRGLRDEILVQLANQAGVGGATSERVWKLVAHCLASFQPGPAIHKYLLRLISESTNGRQRSRLLRLVGGAEATQARAAGVARRAPPTALEWRAGDNAMPALPLRLYDDTLRHVSVDAWTTCERAAAAALAAAGHQRGLTGWSLTMEHNGQLTEWAGCEYALDAVGEVEAWPGGRTEPLRASTSRTAPAPPPRASSVDTERAVRPQVPPPEPPKSRSPSIQRMLEDSIDESEYNWKMEQEESHTINKHTNEYSRKISHDILSRDSALNERYFEQQSDKVRSRSLDNLLGEGNPVPPPTKLADLGLSQSRLNDRYHSVERLGGAPSVASSKGAMEMEYGTGSRAVPSRYIKSQYAGKRAPAGSQSSRAYIEKSSEFGGVRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDPNIDEMSDARSLAASIKGGRKYNEFIDDILTCDYNERIDGLLNDKQIDRLIKGGGKDDKRKSSRKESSVDSVDDYITNLFDPIFMNDSLKRLTDGEGLSGAIKGGGATPRGASATTSAINYGALSLPPSMPAMPATPEALAAALGLHLPPPGTVDINAYHQNLQRAFLQNAMAQNLQIQQQLLAQNQALQTLLAGQVAEPSDSVPTSPVRSSTVVHAQVHSPPRNAVKSRRESNESSSTGAPPPPPPPMPPPLHDIDPSEVRPFLDPYGRAKTVRIGKWRWPPPKDAVNPETPQDFTKFKMRQIQRRHTPQAQTNGLVEHEPPRGRSRSEASPSIEWEEFEVDGRNISPSREPPSQRTARRSFEIGAQRPSPGSVGKLKLSSEMRQRLERVTANHSVRSTSSAAETPRTINKLEDTRKLMLERQLGGGRWDAPPPPLPPAPPGPAPPPPKSPPTPPDRPAPPPPAPDASFAQLRRDRDTFGVHQNREADDRNAFLANWSSRRKDETDSNQGDDLASRFLTADRRERRVNEWGDESDVRGYSEERQQHGRDEWDSESGLDTTDRRDLRDNYSGREASEIYEIHPTRAERRKEENELAATFERKRSSSYFDEFDRFDGRKNSRDMLVGRMRDSPRSDVVFPPENTETSRRPERATFKTHMAQKERERKIEAERRQSVSTHATDRTEHIERDVPAPAALLPSDRAYLTYTRVPWKLRVRKEVFTPLETYSEPNILDLLYAQIISDISSNMASLRISASERRAGQAWLRAQGVGGGGAPARAHTKRACVEMARGWPFYFARLFSARLPPGESAVLAVTHAAVVIGVKGPSGLTVRRTLSLGGLRASAPAPGTLQLTPARDSPLTLHAPLAHHAHALIVEFALQYTQMGSVKKRACGVQDASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCG3</accession>
    <name>A0A0N0PCG3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid synthase</fullName>
            <ecNumber evidence="2">2.3.1.85</ecNumber>
            <ecNumber evidence="1">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="2"/>
    <dbReference type="EC" id="3.1.2.14" evidence="1"/>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCG3"/>
    <dbReference type="STRING" id="76193.A0A0N0PCG3"/>
    <dbReference type="InParanoid" id="A0A0N0PCG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="460" mass="50728" checksum="CCC9C2B358155AB5" modified="2015-12-09" version="1">MQDEDVQLEIGGTLQQRISSCLLSLDKFLKQDAPIVSSIVVAEKKAGGSGCGNIVDTVAQIMGIKDLKTVSQQVSLAELGMDSMMAVEIKQTLEREFEIFLTAQDIRTLTFARLVELTAQREAAASTSAARPVQADAAAGLRVFIRNFGDEKLASEPLIYMSTMVSDGGDNEVPIDELEPVMFMVPGLEGCAAVMEPLCRRLKIKICALQLGIEFRNENLDSMVDRLHQTMKSRLVPGAPFILLGYSFGTLPVLRLASALENDGHNGIVFCIDGAPDFLYSLLTMTLDTKDDVLLQNTLICHTVDTVAPNNDVTSTLMQKLSEIESYEERIKYAITVAPVRQKYSDNFVSAVAAASFDRLKMVLDFKPLEKKLSAPIFLLRPKDPPPFVTCEENYGLDKYTESQVTVHNLEGNHITIIENKDCANIINRILLEKDKNIDTGKTALNVVTSMVENQRTVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCQ5</accession>
    <name>A0A0N0PCQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intraflagellar transport protein osm-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCQ5"/>
    <dbReference type="STRING" id="76193.A0A0N0PCQ5"/>
    <dbReference type="InParanoid" id="A0A0N0PCQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="706" mass="75861" checksum="DBC1E556CAD27B54" modified="2015-12-09" version="1">MSVCQEASQYEAMLRLVAAHRSSLLEATRRHVAQALHASGDLRAAETYYIQAGEWKSAVQMYKSSGQWESAERVARAHGPAAAQHQVALQWAATLPPAAAARMLAARGLAAVGARWALQAQRWDIASELSEVGGGVSRREVARYEAAALAAEQPEDAEAAYLRAAAPEDAVRMWLDQGEHQRALRIAETHAAHMVEEVLVEGARVAAERGDLVQFEALMIRANRPAEVVQHYRDLEMWEDASRVSREYLPDSAEPVPAAVPPLLRRAADHADRGEWWEAVQLLLGASAAGAAGGALRLAERAALRAARLARDHLEGTRRRAAADMLAERFSAIDQSEVGEQLRAALTEGDVENASGVDMSEEEEEEVVPVTAPGVVVEVGEGTEVAALDKLARAGHWQRCLAHAGRSAPHYALRHAAHIFNAHSRVEGVDIESEEVPEALSEALDSLRQYLVSDGEAVVQGSDAELAGAVCRELLVRASTAPQALQALKDAAAVMLAAGADDRSLQAAITLLMGLHVPQIAGKVARALPRYTDIIVADVAFLRCGMCVRAEGAASTREAFVLLNHCLDLAEAADDNMQQLLSYSDFEVTDWPQNRLLLEKSCISGAPLQETREWVLSVVMDQDVEQALPVDSRGLYAASVAPDEPCCVLTGYPLGTRLVTFSNGRCANREWWSRCKKAAAGGGGGAAGALLQHIASWCGPPDLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE87</accession>
    <name>A0A0N0PE87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythroid differentiation-related factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459910">
        <property type="protein sequence ID" value="KPJ19335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE87"/>
    <dbReference type="FunCoup" id="A0A0N0PE87">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719349"/>
    <dbReference type="InParanoid" id="A0A0N0PE87"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056583">
        <property type="entry name" value="EDRF1_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23723">
        <property type="entry name" value="TPR_EDRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="225"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 TPR repeats region" evidence="2">
        <location>
            <begin position="824"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1203" mass="138047" checksum="7DE555E2BD1322AD" modified="2015-12-09" version="1">MEDRENENEHMKRNKDRSPSPGIKSTAVVKYTAFQSPVGYARLQCNTDLNMPPSNWGAAIDSYGLKQILTRGTGFSSFRMAHMFPDCVGEVDVISDAECIKKLLKLPYQPNGTVSMMVHRVENTLLLDDFDVYDYLMKSEWSWLKDFFYENIVKTMSEQERMSLTPGPGARQALQLTQQFLSHSVVERPSPLETPVHAENTPMCLTGPFLPEPETKVEGPSNEQPYNRNVLWTFEDIHMLVGSDLPIFGDKDRPCVSLRLRDARDPINVLTGIDYWLDNLMCNVPEVLMCYHLDGIVQKYEPMKTEDLPNMENSKFSPKVIRNVAQNILSFLKSNVTKAGHTYWLFKGPHDDVVKLYDLTSLCPDSLDNPFTTPVAMLLYRVARNMRLTNRSRHVKQLLEHVVKLLKVERYPQIVASSHYMLADLYVPATTNPACPDFKDESSDSEDEEDFSEFARETTGGNENTSDKDGEGDTKTCKRDEDNEKVEITSEHSDKEEEGNDAGEKEEEIKNSGGRELALRHIGDRIKDTAPDAKAKSSNTGGLGVQVPERCGRALRHALRGLCALHHVTIGRNKDEERERLKQQIIIEEQHPKMANPYEPIKMNYEPLNKKKQDPKEHVSRSRRRKRERKNTDKSGNYLIEANTNIDKNAILIRKENKMASWHEPNRDDNFAWKLHLKTLLYEKICLAYATLAEYSYSHEQYGFSLKYIDMASKCQTLLSNMIIKSRVVDASCLIGRVGDNFFQLSKHWNRLEQFRKQFETDHEIDGSIKMEIEKDMCEEIEGDAKDEFDLDISLPSSDTEAMLLSCEYYRRAGQFAAAKRSELLRRLASVCNELAVRFMNDAQQIYMKYVEEPDQKDPKAKLLLKQFTNLSKRSSECLDEATAIFEKVNDIPNLALLYCNKGRYMRFKAHCDQGGFSAEKRSLYNQAEELYLSALKLLGPRETCGATSIWELVCWELSCHLYTRAVLMQDCPGLYTNEVTEVAEAFKHALKYCPLSPGPRQYLYQFRAAMIYHRLGSLYHSQFRITHEEGARRRALLNATRIQYESAANLFAALEDAGMVLTVRLEHVAAMETQAAVSPNLKLKSLQTAVQLLRQCHSVMTLLKNKDPEEKEPPKPEDAEEKTIKNEHSLLSLYENRLHFILKSIIQYCRSKSNKDYDKMTDMYKKIYCASLKIKKNDDVRLYAASICDVLTAMDEISKEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF86</accession>
    <name>A0A0N0PF86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat and fibronectin type-III domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01011016">
        <property type="protein sequence ID" value="KPJ20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF86"/>
    <dbReference type="InParanoid" id="A0A0N0PF86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF1">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11427" checksum="1F9068F645DC5E1C" modified="2015-12-09" version="1">MEKHTSSSVHFRLKLLTAAAQMQSALGIQDLGQLYHKPLRDAHGTVVVSCVCAARSAKVSALNSRWAPVAKLRRRVLSEDNTMADLLMASVHDQIAYHQVYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6V2</accession>
    <name>A0A0N1I6V2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6V2"/>
    <dbReference type="STRING" id="76193.A0A0N1I6V2"/>
    <dbReference type="InParanoid" id="A0A0N1I6V2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="304" mass="34933" checksum="EA5F01E09DCB80A8" modified="2015-12-09" version="1">MCQFYALSLVAPSIETELLLNTVGCLAVRHSGVDVQLTRSHYETHIERQSDPYRRKTADVRDSTRNDEPVASNMASTDISTSSQQSTAPEDHKRTFDDAFLNRLKALVERLRLDNANLKKALDSERGEVRALKARHESTIRNLKTEYKKKEEFLEKQLRTCSIKPEKLEDSQSSCNKIIELKRLTTEIQSLKAANRGLQDKLKVAQAAECARAAELRAQCARHAATELTARRDARAQCHKLLEEIKSKERVIAQLRREAARATTSHNEQVRADYNFKYWRKLWKTKHKLWYNINTQGGSQRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I708</accession>
    <name>A0A0N1I708_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wolframin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I708"/>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I708"/>
    <dbReference type="KEGG" id="pmac:106717359"/>
    <dbReference type="InParanoid" id="A0A0N1I708"/>
    <dbReference type="OrthoDB" id="5865303at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045400">
        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045460">
        <property type="entry name" value="Wolframin_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045461">
        <property type="entry name" value="Wolframin_OB_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WC-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WCOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19914">
        <property type="entry name" value="WEF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin EF-hand" evidence="3">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="4">
        <location>
            <begin position="652"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin OB-fold" evidence="2">
        <location>
            <begin position="761"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="884" mass="101311" checksum="0DC4F957390E8427" modified="2015-12-09" version="1">MPVGRKRWNLHDGPQGSLRRLRNQLAEDGCAESQVVLAKQLLEEKCELEADKISNFKQALEWLICATEQAHPEARRMLRRCIRSGVIDEDSAAIVRAKSCLAASRQEIVARKAARDLFASLSNGEQYITTAQLERRIREICTTTLKKDEEDSDTADEDTQDEACALDGEQALEPSIFEAGDQIHVNGTIRTAQSDEDYHEEVDHRYIRNLTVDNLVSAAVDYCQGELPLVSYELTLTDPNIKALDHIPLFQQAFLHPIVFIQVMYLKLLYYFGTFSFRLSNIELSFLLVAYLSTNTENVYHLVTLILYYVSFVSMVISTFKMLLAKRQFIDFRKWSGLFLRYSDGNLQTDESENLFVRNNLYPFVQFFISLLVNLFLYPFISTQWVPFSEFCVLSFCLMFLTLFSFGTNGNLYPDVLALVSFGINVLAKYPYEKDTVVHQGWRFLDLHISNYPSYILGNSIEFCLNSRVFFSLLIPIILLSMAKRSDWQVFFKYTLPHCVTLSWLQMFITCSHGCTTYGLIRGTLALVCSFLFLPLLGVITVTLPIFAFLQYITLSRLFYTVSILVGFGIILLVTCVLAKSEATKKFVTPLQLTIGLFTLLYLSNQIIGDIQDDGFPSGLIELIGEDKSSIKNLLKNEFITDYEDNNYQITWDDYYTQCNTPSWIETNMADAQIRCSILNGAHVNWEGYISEVRLINVKNQFNDFAAWLPSFLQEYFKCYYGEEYSNFCQDTNRADSVGGCEFVKSVARQSGKICHLNNLNEYSHEIKLIMEASGGLLKRHADISIKFDHYFSNYTRLLRADDKIRFKGILMNDHNLYTIGSKDIKIQGYEINCIECKNTREAITAPRPTVSKLNKLIKTILNDCIVSTKYILNFLLNPVIVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7G0</accession>
    <name>A0A0N1I7G0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein OTX1 B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460601">
        <property type="protein sequence ID" value="KPJ13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7G0"/>
    <dbReference type="STRING" id="76193.A0A0N1I7G0"/>
    <dbReference type="InParanoid" id="A0A0N1I7G0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="414" mass="45685" checksum="F4DE4983AD2B6D3F" modified="2015-12-09" version="1">MSARALSTNLYDIKLRVNPRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQSNTQMSSKSSSSSKSSLSSSSNLKSSSNTSKTPSSKAPHSSSTTTNSSSITTSSPNLPITPTTSVSPPINVICKKESANYETSPLTKNNLSITHQYNTEAIRLSGKESSPSENITNVHGYGVTPKQELYSSPKRLDYSSKIDYTEKSFGSNLVKDQYSSRLTGNLTPLGSNSSIMTTPSPPITPQSINGPGNVYHPDYNSFHWPGSSDYIRSYSTSHHHQGYGQSAYNSPYYPSQMEYFNGSSVNQSHGGHHGHNLTANGNQLYNQVSFGNPSPPAAWPSHNILSSGPESPENQAQNSPHLSMLQASQITNFSNSGNTYFAPEKYGINMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8S9</accession>
    <name>A0A0N1I8S9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein bowel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8S9"/>
    <dbReference type="FunCoup" id="A0A0N1I8S9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8S9"/>
    <dbReference type="InParanoid" id="A0A0N1I8S9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="499" mass="55761" checksum="304999E869059142" modified="2015-12-09" version="1">MFSALLLVKRSDTKRISMLAPRVNKSVGLSTRNRSSADSIFALPADRVPVVDTIHGFNPTFHLPHCVLTRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECNSCGKVFRRNCDLRRHALTHAVGDVPPGDVLDVGEEDIGRPGSPIEPGYDDEDPELSSPEHSPVRRARSSSIESVGREQSEERPRRPSPSPVERTHCHHNEPRDRASPYTMRPQYMEKHKLSTSDLYEKRRYTSEEIIEKEMRYTDIPDQQVRHPQLQIRRDLHQVQPPDPSKIGHITNPPLDPGPSGIYLSSFRKRTHPPDIGDNIRTCASVYRSRSPEPTNLTMPRPPIGNGDVVVAMPPTIMGIQAYHKFGLPMPPPHPQIPYGSVPHTVLGPQQTVAQDLIVKHAPPKDSVPSTSTSVTNCKELLPSQTKESEETCSSAIANGIKNIVGIQPPTNPKPGTSNSSGPKKGFSIEDIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA08</accession>
    <name>A0A0N1IA08_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01690</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459998">
        <property type="protein sequence ID" value="KPJ18501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA08"/>
    <dbReference type="FunCoup" id="A0A0N1IA08">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IA08"/>
    <dbReference type="InParanoid" id="A0A0N1IA08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ18501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="411" mass="47999" checksum="E698097290619CFC" modified="2015-12-09" version="1">MEKRVTYCTDLEKSVIISNFERRGWIQVGPEDEWNFYWSFTQNCRNIFSIENGYRMNDNQIINHFPNHYEISRKDLLVKNIKRYRKELEKEGNPLAEKMEVVLPSGQVATRYVHLDIIPVTYVLPADYNMFVEEYRKSPQSTWIMKPCGKSQGTGIFLINKLSKLKKWSREAKIPFHPQLSSKESYVISRYIDNPLLIGGKKFDLRLYLLVTSFRPLKAYLFKHGFCRFCTVKYDTSVTELDNMYVHLTNVSVQRHGVEYNSLHGGKMSVQNFRLYLEGTRGRSVTEKLFADMHWLIVHSLKAVAPVMANDRHCFECYGYDIIIDNTLKPWLVEVNASPSLQSTTHNDRILKYKLIDNIISVVVPPDGIPDARWNKIPSAEALGDFEVLIDEELMEKEENGCRPNKNSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICF9</accession>
    <name>A0A0N1ICF9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01024244">
        <property type="protein sequence ID" value="KPJ21126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICF9"/>
    <dbReference type="STRING" id="76193.A0A0N1ICF9"/>
    <dbReference type="InParanoid" id="A0A0N1ICF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13629" checksum="B5FEA606CD5B8A04" modified="2015-12-09" version="1">MEKTALKVALVELEGSPLPVYFISWLQSMFLFFKVSGIPQKEVDDPPKEPAKDLDTFDLLQRARFWMERGNLATAIRYVASLEGASLVAAETWLEAARIHLEIRQAAEAIIAHAAALGLQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE42</accession>
    <name>A0A0N1IE42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460633">
        <property type="protein sequence ID" value="KPJ13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE42"/>
    <dbReference type="InParanoid" id="A0A0N1IE42"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="17358" checksum="0D69B9126EA3BE64" modified="2015-12-09" version="1" fragment="single">GRVGELRTRGKYGLASIYSFPPPRGSPVLSSVSFRHFSATQKLTTAGYAQFESTPEKKNLEAKEQKKLDKKRKAQEKENKTTSNKLKKKSTVIHPPKTGLCVQSVTSGLMRPALQEVLLKALLVIFVYDVDLVRKYPMLSVINSGSVRIYPERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEK5</accession>
    <name>A0A0N1IEK5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein CASC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_01184</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460900">
        <property type="protein sequence ID" value="KPJ10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEK5"/>
    <dbReference type="STRING" id="76193.A0A0N1IEK5"/>
    <dbReference type="InParanoid" id="A0A0N1IEK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028544">
        <property type="entry name" value="CASC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434:SF0">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="19">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="8175" checksum="E5B10F0BAAD376A1" modified="2015-12-09" version="1">MQLLKVAEPLQDGVAIESDYDSAASESENSERDPETQETERRVDDDEDRSNPQYIPKRGTFYEHDDRTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEY0</accession>
    <name>A0A0N1IEY0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative G-protein coupled receptor No9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_02987</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
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                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="976" mass="107297" checksum="844FE2D467ED7FA3" modified="2015-12-09" version="1">MWYLVFLTVFGVCSGYVEQKFAMEPQDQTAVVGSRVILPCRVENKVGQLQWTKDDFGLGLHRDLSGYDRYKMIGSDEEGDYSLDIREVTLEDDAKYQCQVSSGLRDIEENIKGRPKKVWIEYVWRTTPTYILCLRRDKAGEPAIRSRYARLSVLVAPEPPKILQGNFFSTAEDRTIKLECVSVGGKPAAEITWVDSNAGVITQGVTNTIEPLSDGHRFTARSVLKLTPKQEHHNQTFTCQAQNTADRAYRAASIQIEVKYGPKIKLFKKSGNKGKIPEGEDLIVDCKADANPNNLTFKWYLDGELVGNNSELIITNVTRKHNGAVLKCLVYNEVGKSEESETLEVTYAPSFRSFPKDVEAEIGKVATLSCDVDGHPVPEIEWLHREEDQNIRVGRTANLTLTVDTHTSGRYICKANVDGYPEIEAEAAIYIKGPPKIISNQTQFGSQGDSVNIECAAFSVPRIDNIYWSFEDKDIDAVHDQDYAFLEDLQPGGVVNSTLIIRESQSRHFGTYKCNVSNEYGSDVLEITLKPTKSFPLLLILFGATSGTIMVAALIMLVILCQRKQRKNKQAQMTEKPDVTVTAEELFKENDRNSNISDLKLELRQVNESFPLLLILFGATSGTIMVAALIMLVILCQRKQRKNKQAQMTEKPDVTVTAEELFKENDRNSNISDLKLELRQVNGSCEVDYSNTGSDSTLCSNAKLGSGIPLAGTVALSAVNQTNTYQGYRYSNDYTDPAYSECYKGNGFNNGYQTYVHYGHDYTPGSLRVQSPTLSGEKLTPNRSINGSLPRSVETSSTVQFNATNGSQNNSLQRSTKRQDSSNALNNLGVPTGEGSRVPNGGIIHGVDVRYAATYGNPHLRTTTSLGFPTVNTAKPASTPAPPPYSSVRNSVILPSGNSSHSITSPTSLASPQCATSPITNSTMSTESAQPVVGATSTTPQSPSSHYILAPTTRALSNTTVTKKGNGHQQPLATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGA9</accession>
    <name>A0A0N1IGA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460501">
        <property type="protein sequence ID" value="KPJ14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGA9"/>
    <dbReference type="InParanoid" id="A0A0N1IGA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="362" mass="42558" checksum="EEFBF1DC84BD056A" modified="2015-12-09" version="1">MEKLRFKFEVLASSDVKTNMLCITSIETPDGRTYEVPDDLKAVSKHTAILSSEVYNKIKNSLKKRHQTRSVWIPLDTNFRKIYLDAGENVQFGDQYLEEITVKSNPSPDNTSSYLSEKKNLGKAAERFLMERYSNKTLNAEQWINEFESECERFEIIQSEEKIETLKHLLEKHCLDWYSSMLIKLTVNSQWKVWRDNFCETFGNKGWSQIKYAFTFKYQAGSLLEYAIKKEKLLLDVNKQIDTQTMINLIVMGLPDHIIDKIDKETAKSTASLYNEISKHEYVTNKKDFSKNKIYTNQYKGKMDKIKPCKICENLNKGVRFHPEEKCWFRQTKINDHNRNSNKTVNNSVIDIELNNEYQKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGP5</accession>
    <name>A0A0N1IGP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neural/ectodermal development factor IMP-L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460423">
        <property type="protein sequence ID" value="KPJ14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGP5"/>
    <dbReference type="STRING" id="76193.A0A0N1IGP5"/>
    <dbReference type="InParanoid" id="A0A0N1IGP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873942" evidence="4">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="235" mass="26362" checksum="1BEE70704386DCE2" modified="2015-12-09" version="1">MFYLVLLFAAAALLSGGRSSNVNRHMKLLELDNNVLNMQSKQATKKFVALIKKPNAVSFHSTGAPLELTCEAVGTPAPSIHWFKNDAPVYEVSCPKKPYTDLSERSKLLPFAPRILVTYKVLVDCIGCNVVLPCRARGHPRPKFSWRDNTGRPVGNDPRMKVLRSGELIISTLLWTDLGEFTCRATNMFGSTLATTFVYPARMRRLIELYGCPREDHIPNNIYNLFCSSLNDRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGU3</accession>
    <name>A0A0N1IGU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Wilms tumor protein 1-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_02631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGU3"/>
    <dbReference type="FunCoup" id="A0A0N1IGU3">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGU3"/>
    <dbReference type="KEGG" id="pmac:106713320"/>
    <dbReference type="InParanoid" id="A0A0N1IGU3"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09352">
        <property type="entry name" value="LIM1_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000028">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047245">
        <property type="entry name" value="Ajuba-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="499"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="564"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="625"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="714" mass="77593" checksum="96BA18EEEB26BC41" modified="2015-12-09" version="1">MDSSRRNNAEEQRCILGLQDLKISNKTENDTEQAHSAPANISAVGKARPVGAIESFTLDSAPTNREDYSFYERSNVIAASKFATPKRVETIASLSKCDINTTALPVSPTRSVDSVSQRSLSYQTEDLYEIPGNTNPQYPPPVYENIDYYGEQRSPQPPYYHQIYQQGPPPPVSDGYYDTRYSKAQPQVPVSSKSKLNPIVYENMLCSDNDKKTEYKAQPAQDQQFVQQGSIPGPQVPNSNLNRTMLHMTNDKTKVEKAPPPSYNKAQNNHSGDYTIMKSAPPKYTDVSALLKSDNTVSFDDKVVTIPSTAIYASIAPSAQRPKANIATEVQTLTPAPKFFHPKPNIGNGLGKDKAPVLAPVNEGYIKAPLNSRMQIVDDTNGSDYVCMTGGSSAAAVAAATRDNVSLASESIGSRNLASGLTSLCSPAQSPAPSPTPSSVSQVSAGSRGSGGRGKSLLPYSITPPRPPGPSEAQRKIEELTRQLEEEMERQDEDGEYFGICHTCRGGVTGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGKVYCEEDYLYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCICNECLDGVPFTVDVDNKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDRDFHVDCYMCCVCGMQLTDEPDKRCYPLAGKLMCRACHLATIGAATGPGMPPAPHLSPASYKYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJP4</accession>
    <name>A0A0N1IJP4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJP4"/>
    <dbReference type="FunCoup" id="A0A0N1IJP4">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IJP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="538" mass="60339" checksum="BFBC792FC890B981" modified="2015-12-09" version="1">MDTKNDGHGDEIELTVQGASSKPSEMATKSDLPERGSWGSKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFMELAMGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAIFYFFMSMRAGNVFKSIVCMCHGRTCDNYWNTVTCVNPYDRKNLTCWSTFDMTTLCTLNGKNVSKALLSDPVKEFWERRALQISSGIENIGNIRWELAGTLLLVWVLCYFCIWKGVRWTGKVVYFTALFPYFLLTVLLIRGITLPGAMEGIKFYIMPNMSKLLESEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCSVNSSTSMFAGFVIFSVVGFMAHEQQRPVEEVAASGPGLAFLAYPSAVLQLPGAPLWSCLFFFMLLLIGLDSQFCTMEGFITAVIDEWPKLLRRRKEIFIAITCVISYLVGLSCISEGGMYVFQILDSYAVSGFCLLFLIFFECVSISWAFGVNRFYDGIKEMIGYYPTIWWKFCWVGFTPAICIVSINHCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IL29</accession>
    <name>A0A0N1IL29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01054970">
        <property type="protein sequence ID" value="KPJ21559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IL29"/>
    <dbReference type="STRING" id="76193.A0A0N1IL29"/>
    <dbReference type="InParanoid" id="A0A0N1IL29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7384" checksum="BA455A5C01935299" modified="2015-12-09" version="1" fragment="single">VVDGIVKAFSDQPNLHQRAVVTSFNPFVLYRIRHKDPKIVGAMSYRPYCFSAQDYDAENGPSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INK3</accession>
    <name>A0A0N1INK3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INK3"/>
    <dbReference type="InParanoid" id="A0A0N1INK3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="16674" checksum="98541DC00F9D9582" modified="2015-12-09" version="1">MDKQPPSLKRDNEDHNLLERPSIAYSSTTVRRAFAVWMYCGQSNKFKHVCNYYHYLEALEDTLPEESRAASRQHELNLFTSRPPLSSYLMKNFPTLYPAVTQQNNQKTSLETNKQNINKKQNINQKIQNTDKSENTKHWYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INW0</accession>
    <name>A0A0N1INW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amyloid beta A4 protein-binding family B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460786">
        <property type="protein sequence ID" value="KPJ12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INW0"/>
    <dbReference type="STRING" id="76193.A0A0N1INW0"/>
    <dbReference type="InParanoid" id="A0A0N1INW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000317">
        <property type="entry name" value="Amyloid beta A4 protein-binding family B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="291"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="464"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="615" mass="68432" checksum="18143E0219CFF04A" modified="2015-12-09" version="1">MGPMYKGQRNKLLKHSCTFVRCRHRQVSCPSGRVSDGPSPTHPDEGPKGSKLDDETYGFRVGLRDPTSVDVWRHSFRSDGCQPLEWSTLLQRHHSDLYDMHDDKSMADVYDNYLDNRRVEDEASSPVAKANDKSGLITPPQQNGGEDSPPPEKERADREDSEKSHSGPVPHCAGPNDDLYAIPVKLRPKKEPQLPPGWEKHEDADGPYYWHIKSGTIQRELPRPEGRERLSMVRDCSSLADAKYEMASSVVRSTTSGALDHVDVEERKRKEEISYKRRSYPARGELEGRAVRFFVRSLGWVEIGEEELTPERSSRAVNKCIVDLSLGRNDLLDHAARWGDGKDLFMDLDDGALKLIDPESLNTLHTQPIHTIRVWGVGRDNGRDFAYVARDRATRRHMCHVFRCEAPARAIANALRDICKRIMIERSLQPPPRPTDLPAARRPRPLSGASFPTPMEEPRKTVRARYLGSAEVPRATGMDVLNDALQRLAAARAPSAWRPVAVAVAPSMITITEEGETSPIVECRVRYLSFLGIGRDVRRCAFIVHTQHQQFVAHAFHAEPSSGALCKTIEAACKFRRRGGAGGRRGGAASGAEGRGSLGAALKSFVGSLTGRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPL6</accession>
    <name>A0A0N1IPL6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="KQ460229">
        <property type="protein sequence ID" value="KPJ16417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPL6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPL6"/>
    <dbReference type="KEGG" id="pmac:106707891"/>
    <dbReference type="InParanoid" id="A0A0N1IPL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13000" checksum="6C8AAA3A8120604E" modified="2015-12-09" version="1">MVIEYVGQMIRPIVADVREAQYEATGIGSSYLFRIDLDTIIDATKCGNLARFINHSCNPNCYAKIITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDEKIPCLCGAPQCRGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ22</accession>
    <name>A0A0N1IQ22_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IQ22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF89">
        <property type="entry name" value="GH15894P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1464" mass="169165" checksum="66BB51A9A03B448D" modified="2015-12-09" version="1">MYTESITPTVSLNSEQSSRTNSTNCVDSDSKDSDSGKDSASDSFNSLIEDKVEDNCSNCLDDCIDVKCTGTQYSVPYGEDQCKVIKKRSVCCNSVTQTVWGVLLIIISISGFVFSPLDFMLWEKLNMRPGLPPYEWWANPPDEVKMRTYIFNVTNHERFMKGIDKKLNLHEIGPIVYLEKLQHYNMKFNENSTLTYTAKRSLIYLPDENTYDLNATIIVPNLAVLGMASFLHDSNYFVRTAFRLLVNAHGSEFFVNKTLYEYLWDYRDPVLATSKNIVPALVPVDNMGFLKRMYSDFIDEVTVNIGAERGHDNFFKINRFRGQPQLPGYDPATCPDRIFGSTEGVMYHQHITKEDVLLYWRKTVCKLMPLYFESELSMDKVPLYRYNLSEVVFERVRNGTDCYDTTPSLPSGLSDASKCYFNFPIVVSYPHFYTGSPPKDHYVTGLTPDREKHNSYVVVEPITGVPFRAVARMQSNLRMHDLSLFTTEYKRFSNHVIPLFWAEYSQEGLPTVIKWTIYFMVVILPPLSVKKTLLNSDKSKVNCDNPNINLNSDVEPNIETVASLLTCRGLDNNLEMNCNKSQKQDNQQSQKFVSSEKTFLLHSQIHTPSTTKENKQKFKQQKKKEKKTIAKNHRSFSPPLLKDSEGRQRKVIWDPYIKFHSSDNQSEDFTKEELSSITNKMEDINLLSCSNNILTGEKECDNFIMQHDLKWFIFRDEPQNEEMVRFQTFGQNGMGKALKKNMAKMKHETKDTCFIVIDLNVMLSDFQFVNDKVLQDTRYRLVIPNAVITKLRNLAEMDHKSHQLMVTAQNLIWKIPTQSRHIILEPEQPLTQTSQQIISCCKKIKNLDYNLILLTSDADLYASAFDHNLNCYMIQDVKKGLCGQLFNDSNIREEKDINNNLFLQKLEDIEPFNFSQLTNDVNENFPFFDDFDYEQAELKETVFEKLKKYSLRNRHMASLIILRAEDYMCTFTQIMETFMLDLLLNENVSCDFCTIPQAVDAVAQLYPYSKSIQIVAYRMSALYNLIKQKNKLETKYKADVLIKMVGCGMILVESIKAFKPNSEIMSETEYLLVKLLQSIENPNRFGNDLEQSKIVRKYNSSEISYEDYDNRPAEDYYNEHLTDVNGNEDISKQTNLINNRIIRTTGRNLNSLIISNTNILLDIDEKCDIKIDNKFIEENNIDIKLNLNKDNDISKTVFDSTVHENAFTSLENAPKVIRNFDAIKTFEEKILNKSLEEIDNIDVKFDLNINKNEYTNMDLDKISETYTDIAYQTEVYNSESLNDKCVTENQTLSASNDSGLGKNCNAHLVIEKFIYEMSSTLKIVYDFIKDTSLVLKGKDIKPENRREIFDKAYKTYHRMSLVVDNLTNILKREEEAKTTVITLLERAGIDVANNKLINKYKQIVSAYLEQIDLLQQALKIIYITTNNIGTANAEYIRLQNVIQNYGLNKAYKLRQSIKVIGFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQV2</accession>
    <name>A0A0N1IQV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein abnormal spindle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047248">
        <property type="protein sequence ID" value="KPJ21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQV2"/>
    <dbReference type="STRING" id="76193.A0A0N1IQV2"/>
    <dbReference type="InParanoid" id="A0A0N1IQV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="199" mass="23259" checksum="0D5EEBE2AB5C4D16" modified="2015-12-09" version="1">MYQNNAYSVVGHVYVYMAFMNRSISSVEVLKYAAAVLVNLARYKDTGPKIYKRDRIPPILKFMLRFSSSETKLFCIFSTYLWIFSKYEAIKQDLTEFLHIPENHKTLMTIKNNVDRMKRMTNNSKHRFHTPQPFKTMPRIFNHHGDSLNQSIANTNCTGRTKIVLPALKPTYGITRIEAPQYFEDSQQAIDCLIKTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFV2</accession>
    <name>A0A0N1PFV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFV2"/>
    <dbReference type="STRING" id="76193.A0A0N1PFV2"/>
    <dbReference type="InParanoid" id="A0A0N1PFV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12394">
        <property type="entry name" value="RRM1_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF386">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="340"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="763" mass="85340" checksum="A92735E831406065" modified="2015-12-09" version="1">MDYVVGSVAALVTGNVTPNRPKFLKRALTPTKHQPSPNVTPKSELADDRSIFLSPTLQKKKAVVKKSPKRIFENPDLDVTNDEEGSTKSKSPKAEKVKKHLKEDLDADLSPKSIKNKSPSIKDVQFQSTENEDMDISGSSQVENESTPKKKKKKQSLIMEPIDNINTSIDNIDEFKNKTISPKKNKKGKKKTNVETNVDTENNVSHTNETQNNETEKSDTEENSTVIKQSKILNNIENLENPKKAKKKNKKQKKKLNNKTDPTKKKNKTTVNPNAITDKDSDSEHDSDNEIDSEDEQNNKEVLDTGPADDSSEDEEKKPKKKEKVQKKEVVVNTEEEVKRTLFVGNVPFSPKCKKEIKKIFSKYGQIETVRIRTVPVKDGRATPKLAVIKNDLHPERSTVNVYVKFQDASSVREALAENGTVLNDHHLRVTFSDCTGSEHDPKCAIFVGNLPFALEDETLQQKFQQCGEIESVRIIRDSKTKVGKGFGYVNFKSKDAVELALQLPEEDLTIKNRILRVKRCMQTNSKQKPQQENRRGNFQGGRGRGNTRGGFDRGNTQGGFGRGNEQGGFGRGSTRGGFDRGNSRGGFGRGNTRGSFGRGNTRGGFGRGNMRGGFDRGNVQGREQFWNGDDKQVGRPAYNDSKADGAMRRLMKKRSNQDGADGPPNKMQKTINQPGKKQRKEFVGMTAEKKKKSKFDKGQKKKKALMFVPMVATPHCCPKTTVKSVLSELPTGVDVAKLAAFKLYLDFINYMARFRPEAEVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFX4</accession>
    <name>A0A0N1PFX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460786">
        <property type="protein sequence ID" value="KPJ12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFX4"/>
    <dbReference type="KEGG" id="pmac:106713886"/>
    <dbReference type="InParanoid" id="A0A0N1PFX4"/>
    <dbReference type="OMA" id="RGQSTYY"/>
    <dbReference type="OrthoDB" id="7333821at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="215" mass="25745" checksum="D92CEA51E1996192" modified="2015-12-09" version="1">MSFLTEYFDEFRQHPIKKTKMCRPENRWATLEGKWLDPKKGTEDKTWTEEEIEKFIKDTMRRLRGQSTYYNDFCAHLSPEFKTRPFKPRVKKLRPCGEKTEVMQEEVQPQGEKLAMKDTELMKVARDMYEAPPRPTLRPLPTHYRILGYVRPTNYNTGRSDYQEGIARLAYELVRDDRIPRYVAHNGCRPRWGLPPEGQRQPELDIVPFEEERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG28</accession>
    <name>A0A0N1PG28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium-independent phospholipase A2-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460689">
        <property type="protein sequence ID" value="KPJ12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG28"/>
    <dbReference type="InParanoid" id="A0A0N1PG28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="442" mass="49298" checksum="0B2714BA11D8B0BE" modified="2015-12-09" version="1">MSSFGGQWKIIRHYLSMANLNAEVEKLMQKIKPATPEQWENLIKKFEKAVSIRLTQIKEGTKSIDNRPAHVLNASTIENTTRDVQTEKQNTIEKTEEKSQAGLSVGSEIKEITFESFLQGLKLKKDLHFGKISEQSWKSNKPIITKTGAYFACEQDLDSLQPTQHSKESQQPLDVDINTLTHSLCHISNSDCGDTGMSAEKQDDQSDGISIQNIGGVFIVIFLGIALACATLAAEYWWYKWRRRPTISDVTRALALMGYTGPTKGPGPNILSIDGGGIRGIIAIEILRHLEKLTGSGVGNLDTANQMYHTLSKKMFGNTSIIGVTISLSKTSIHSRTAYVISAIVTAETLECLRKRTEHFIDHLIQYPEARDYAIKEGAVRALLRVQNKLRDDTDITREVKGIVNEENIVMLHISEKIFNDMCEVNPHLAMVDYGLVTPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGN5</accession>
    <name>A0A0N1PGN5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGN5"/>
    <dbReference type="InParanoid" id="A0A0N1PGN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="31183" checksum="0D588816C806DC7A" modified="2015-12-09" version="1">MQDQQQQTKARKRVPNFTADEKALLAHLVKRRPIVQTKFTDAKTVSKKQAAWHLITQEFNSNANVHKRETLTLKRAWENMKAFTRKERANLLQTGVHPSSPLQHEALLNMSDEDSSMMLPELENDFDSDSAILDSVDPNSPEPEPPRVMDPIKVEVCMEPEPIENDISTQREDTDTIPGPSQDCNDHIDKGYSRTPYVNQSYRPLDYMRRESILRVRHLERKKKLEMELLKVQLETEQIKQRTALLEEEMAQVKLLQLKKSLEQHNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH17</accession>
    <name>A0A0N1PH17_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460130">
        <property type="protein sequence ID" value="KPJ17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH17"/>
    <dbReference type="InParanoid" id="A0A0N1PH17"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="19770" checksum="AEFDE0786C883BC7" modified="2015-12-09" version="1">MLVCECIPMNMSDVHTVHVCDPEVCVRYGQCESFTPECCCDVPEDYKTSRSVPDLDATPWKVLSTCFGVGLEVIGIVSDLDGVNLWAINLLGSSQDRPFFHHEGHEIVTILDPPHLLKSTIALKPRPQRDTVHVCDPEVCVRYGQCESFTPECCCDVPEDYKTSRSVPDLNATPWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIF4</accession>
    <name>A0A0N1PIF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459761">
        <property type="protein sequence ID" value="KPJ20135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIF4"/>
    <dbReference type="InParanoid" id="A0A0N1PIF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879802" evidence="2">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="19415" checksum="B369E3D8BA4F74D4" modified="2015-12-09" version="1">MDVTTRALVLALAALAIVARAHLPSHDNILRVQLWDAEGLSRDPVPPRISESSLNHRRLKVNVNSLYDAMMKESEHGAGRFARHKVRHKRRRPRQSGTDLPWRFHSDAGSLNVAAFDDTVPWDVIEGDRGLGNASAVSAASVASAAVASGGPESSPRDVSPPMTLRQDEEVMSDGKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIF8</accession>
    <name>A0A0N1PIF8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIF8"/>
    <dbReference type="FunCoup" id="A0A0N1PIF8">
        <property type="interactions" value="2525"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIF8"/>
    <dbReference type="InParanoid" id="A0A0N1PIF8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000729">
        <property type="entry name" value="SMU1, DNA replication regulator and spliceosomal factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="485" mass="53334" checksum="432BC184E6AE8FFF" modified="2015-12-09" version="1">MSIEIESADVIRLIQQYLKESNLTKTLQTLQEETGVSLNTVDSVDGFCADINNGHWDTVLKATASLKLPDKKLMELYEQVVLELIELRELGAARSVLRQTQPCQLMKQLQADRYMHLENLLSRSYFDPREAYGSGGGKERRRAALAAALAGEVSVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAIRDEEDDQCPTQLSKIIKFGQKSHVECARFSPDGQYLVTGSVDGLVEVWNFTTGKLRKDLRYQAHDDYMSMEEAVLSLAFGRDSDTLAAGSIDGKIKKRRERCVRTSVLCVGSIHGLKSGKLLKEFRGHTSFVNEAVFTPDGHGVLSASSDGTVRLWSARTGECTATFKPLGSGEPPVNSLLLTPKNPEHFVVCNRTNTVVIMNMAGQIVRSLSSGRREAEGGAFVCAALGARGRLVYCAAEDFVLYAFCAASGKLERTINIHEKAVIGMTHHPHQNLLATYSEDGLLKIWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ14</accession>
    <name>A0A0N1PJ14_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Iron-sulfur subunit of complex II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_05814</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ14"/>
    <dbReference type="STRING" id="76193.A0A0N1PJ14"/>
    <dbReference type="KEGG" id="pmac:106720819"/>
    <dbReference type="InParanoid" id="A0A0N1PJ14"/>
    <dbReference type="OMA" id="WWNGRRF"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="23" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ18876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="33470" checksum="06849A032A0FDFC3" modified="2015-12-09" version="1">MLRIYKWHSELRGIGRIFYSHKPPAPVKDIGPRRVFKVYRFEGIDSRKEPTIQTFDVDVSTCGKMVLDAMIKIKDMDPTFSFRRSCREGICGSCAVNLQGRNCLACITLIPQSKVVNLYPIPHMYVMRDLIVDMTHFFNGYNSIRPYIIRKTQGPIGQYQYAQSMRDNLKMIGLYECVLCSCCATACPSYWWNGRRFLGPASLLHAYRWIIDSRDEDTEQRLKDLRDDFKAFRCHTIMNCTLDCPKGLHPAQAIAKLKLLISGLQKKENPDMDPSRFASSGDWTQKCKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ53</accession>
    <name>A0A0N1PJ53_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ53"/>
    <dbReference type="InParanoid" id="A0A0N1PJ53"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="20622" checksum="E1F567AE549CB08D" modified="2015-12-09" version="1">MSIRLQEYKDAIEKNLKDRSKPWTKYFDIAESKTGVSRVYIFVGIVAFTGLYLVFGIGAELICNSIGFVYPAYMSMRALESPQKDDDTKWLTYWVVYACFSILEYFSDFIVGWFPLYWLIKCIFIIWCYLPTDFNGSLIIYHRIIRPYYQKHHHKIDDLANSANRFVSEVVGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKG0</accession>
    <name>A0A0N1PKG0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C18orf8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459692">
        <property type="protein sequence ID" value="KPJ20425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKG0"/>
    <dbReference type="FunCoup" id="A0A0N1PKG0">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PKG0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="503" mass="55863" checksum="D244BE84C43F7E1E" modified="2015-12-09" version="1">MVKFSLEDSDPYYLTLSEHPKRFDADSPVTNVFFDDTNGQVFTVRSGGVTGVTVNSMDEAKCTSFRMEDKGPIISIKLSLDQKVLAIQRNNEGQSATVEFVNFKDLSPTNVEYSHTCKWKNSKILGFVWPKANEIAFITDHGIELLQVLPEKKQLKTLKSVSFSGAWFSWCAQSNIVVLAGNNGALLQPFYFNNSTIIKLQNGAWFSWCARSNIVVMAGNNGALLQPFYFNNSTIIKLQKLELETSRPVVERDVCMVLVADVTWCAIFRHALTTIAAPGPTEIWLMPLSGSGVNYTHILKTGLMGRFALSVVDDLVAVHHQSSQTSQLFDIMEECKVENNTVIHLPLVPAHSIRPAVVDEQPCPMYSGNWVMFQPDYVIDARRGCLWRLRLTPAALAHNIEKDDIGKIVSCLLRRRGGADVVHHLLAQLVASAQIYLLQLTHAFDQINSVYRQWAEAELARSTAGGAGGGVGVCARGGELRLHNTRCARECCNRTQTIPTLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKQ7</accession>
    <name>A0A194QKQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L23a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKQ7"/>
    <dbReference type="FunCoup" id="A0A194QKQ7">
        <property type="interactions" value="853"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QKQ7"/>
    <dbReference type="KEGG" id="pmac:106720184"/>
    <dbReference type="InParanoid" id="A0A194QKQ7"/>
    <dbReference type="OMA" id="FEPPRNP"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="291" mass="30784" checksum="1CFCBF445F62C94B" modified="2016-10-05" version="1">MPPKKQPEKSASGSKPAEKKPATAKTPAAAPKAATAASTSSAPKPATAKTPAPAPKAAAPKSAPAAAKPAAAKPAAAPAAKPAEKKSTATPTAKPGSAKAAALKAKSSAKPSAKKAASATKPTKPKPAATKLKIAPKPKKTGIKGQKKVVKPVVKALKAQRKVVKGEHGKRVRKIRTSVHFRRPKTFEPPRQPKYPRRSLPRRNRMDAYNIIKFPLTSEAAMKKIEDNNTLVFIVHTSSNKHHIKAAVKKLYDINVAKVNTLIRPDGKKKAYVRLARDYDALDVANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMY3</accession>
    <name>A0A194QMY3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMY3"/>
    <dbReference type="InParanoid" id="A0A194QMY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="361"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="601"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="720"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="100632" checksum="3374E53E44C7BFFA" modified="2016-10-05" version="1">MATQKAEETYKSIDQLYAGKSVFVTGGTGFLGKVFLEKLLYSCPNIDKIYVLMREKNKWDTTERIKQMLDLPMFQRLKRERPDDLKKIIAIPGNVTSPNLGISEENKIVLIKKVSHVFHFAANIKFNEPLRVAVNDNVEGTRRVLNLCHLMKNIEVFVYVSTAFSNTDQIVLEEVVYPPPASVEDVKRLTEQDDLNEEQSNKLLCGRPNTYTFAKALAEAVVNEEHGNIPTIIVRPSIVSASINDPLMGWVDNWFGATALMTTIAKGVNRIVISKSSNVVDLIPVDYVSNLTVAAGAKYKKSKEVTVYNCCTSAANPLTMGELSALITEDSIKNNFSEIMKPSLMFTQYEWLLKIITLFMQTIPAFVADCWLRLAGKPPRFMKMQTRISLVRDTLQYFTSRSWEMKCDRTRALFASLSVTDRLEFPFDPTNITWSKYIPIYFMVPESNENDFDPIIYYLLNGNETEISRFYNTENEDLNIGGEPIFSDGMWKCGTCDNINERQLMYSETNEVDTNIVDEDFVQVQVGLSFDEMRCITIESDQECTVARAAGDCTGPSVTLIVADSQRFIVRVFGEFDVLPEHSKNSYQPVADFYAGKSVLITGGAGFLGKVFIERLLFNCSEIDKIFVILREKKGVNVKQRLRDVLDNPLFSKLKKTRPNALDKIIPIEGNMESHQFGIKSADRKTILENVSVVFHSAAEVRFHKPLKYILKVNVEEGKLNNYTYSKSMAEALVAEEHGNVPTIIVRPSIVGPIKEEPLPGWLDNWNGATGLMYDMGRGVNNILHGQRDIVLDIIPVDYTVNLALVAASKCSDNNEVKVYNSCSSLDNPITCGHLEKASCEQFKKLHNGKSSLKIYFFKSPWMVSVVSMLFQLTPAYAADFWLRCRGKNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNL6</accession>
    <name>A0A194QNL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNL6"/>
    <dbReference type="KEGG" id="pmac:106719404"/>
    <dbReference type="InParanoid" id="A0A194QNL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="17913" checksum="CD58341F7262938F" modified="2016-10-05" version="1">MDTASIRIKFTPMVKIIKEKSLIYSLEITPEVMYVDNVDKIEWKKENDLIEYIVPMKHRIVLRKVTPDNNDEPNKIYYSCVDLLHTRSINNTELGSGDVSRIISDNVILKTIIPDIRNNEKCKIKLTNNHTLDLETEYDKKANNLLYKSCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNX8</accession>
    <name>A0A194QNX8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNX8"/>
    <dbReference type="FunCoup" id="A0A194QNX8">
        <property type="interactions" value="1390"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNX8"/>
    <dbReference type="InParanoid" id="A0A194QNX8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="39667" checksum="15865CCC1CDB4682" modified="2016-10-05" version="1">MGCRGCLNDTARRLVLMLWTFTNHNKPLMLQGHERAITQIKYNREGDLLFSAAKDAKPNVWWSLNGERLGTFNGHGGVVWCLDVDWQTINLITGGGDSSCRLWDLETGKNIATIKTNSSVRTCNFSYSAYQAAYTTDKAMGHPCEVFIIDTRTVDDSISSQSPILKWEITDSKVTSMVWGTLDETIITGHEAGDLIQWDLRTGKKVHSIKEHNHQINDMQLSRDGTMFITASKDQTAKLFDTSSLELLKEYKTERPVNSAALSPILDHVVLGGGQDAMEVTTTSTRQGKFDARFFHLVFEEEFGRVKGHFGPINSLAFHPDGKSYASGGEDGYVRVQSFDQSYFDYTFDYNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNY8</accession>
    <name>A0A194QNY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNY8"/>
    <dbReference type="InParanoid" id="A0A194QNY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="31970" checksum="87AF798B6DCD861E" modified="2016-10-05" version="1">MPDWRYNVLSTSEAFLDGAGPPRDPLVSSYPRRADRTRPVHTCPYTTIFLGSRSHVPYRLPAHSENGDPFADAYSVDRSSNLTDTSSFARYEDCRPQIDETLSEENDQVYSDEKTDENLPLQVQKVPYTSSVYYISAKTETLNKDGQGTDLFLVEASESDALSSCTCDSFERCEFDCRDFEPFSDTCCCDPLSDGVCSRSPKVVESPEDFCDKTVDEDGASARSDMDGLDLTLFEPAPTESNQCEGQPSTRSAGSAATGLCGVLYAVSDSGNGELNEQFLINQTERNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP26</accession>
    <name>A0A194QP26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP26"/>
    <dbReference type="KEGG" id="pmac:106719253"/>
    <dbReference type="InParanoid" id="A0A194QP26"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="242" mass="25880" checksum="503409A0C2A30BF2" modified="2016-10-05" version="1">MDVDAPNILKRSSSAPLINEAASTAVTSPTTNTAPRSTSFFSMFSNNNLSRTRRHSGSSSPLSAPINLSNVWGKRMTPRVSQLRAEECADVSNTREVAHEREVHCAMQMGQSCEDLALAAGAGAAHSPTRLARFSPVVSPSPTRKYTTRRSLSPIAIRAATLSPVSRPSALGGGGGKRRWDEGDSPLPKRMCTDRLTPSTPGTPGTPGTPDSDLECTFRPVSPRHQPMHEVQDPDTHKATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP46</accession>
    <name>A0A194QP46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP46"/>
    <dbReference type="InParanoid" id="A0A194QP46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6772" checksum="30E893061C5D2718" modified="2016-10-05" version="1">MERQERTYANMEATDTVDTKQWSNALVGVAATPQFNGGRETARAQPRSARSYVTVPVVPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPL5</accession>
    <name>A0A194QPL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxysterol-binding protein-related protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPL5"/>
    <dbReference type="FunCoup" id="A0A194QPL5">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPL5"/>
    <dbReference type="InParanoid" id="A0A194QPL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF141">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="213" mass="23305" checksum="9F7275ADD0C352B7" modified="2016-10-05" version="1">MMKATGLGSHRPLSGQLYKYTNVVKGWQQRWFAVDPETGVLSYYLFDGPGDTIQPGQPARGEAHLAAAVICPSDEDSRTFTINCASGDMLKLRATDARARQEWVNGLRAIAEIHTKAMGANPPLQPREQLAVHDAMASARQQLHLEIIDYDSDAALARCIESSDSPFLHTDPDLLLLKATSAASMQCLLQCLGILHRQQQCATLSGKHADNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ38</accession>
    <name>A0A194QQ38_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ38"/>
    <dbReference type="FunCoup" id="A0A194QQ38">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQ38"/>
    <dbReference type="InParanoid" id="A0A194QQ38"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000026">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="718" mass="79603" checksum="0D7DF41DA1322447" modified="2016-10-05" version="1">MLSDLRPESWWVSAALRTIRAVALVCDILTFPIHLLLQRPWRKRALSRRIKARVIESTPTSVTVRSVSEPSDIHLRLVRDGVTTMEAMLRAAAQRWAQRPCLGTRTVLGERDELQPNGRVFKKFKMGEFVWRSFSEVEAEARQFALGLRELGCVPRTNVVMFAETRAEWMIAAHGCFKQSIPVVTIYATLGDEAIAHGINETEVSTVITTHDLLPKFKKILAKTPKVETIIFMEDQLKTTDREGFKEGIKIYGYKEVVAMGAQSKIESVPPSPTDTAIIMYTSGSTGVPKGVVLSHRNMVATLKAFADAIPVAKGDVLMGFLPLAHVFELLAENVCILAGVPIGYSTPLTMLDTSSKIMKGTMGDATILQPTCITSVPLIMDRISKGITERVANSGAFAAAFFKWAYMYKLRWTRRGYSTPLLDRVVFARVRRLLGGRLRLAISGGAPLAPDTHTQVRLCLCCDVVVGYGLTETTSCATVMCPHDRSTGRVGAPATGVDLRLVDWEEGHYRVRNKPYPQGEVVVGGESVAEGYYRNPEKTREEFVEMDGRRWFRSGDIAELHHDGCIKIIDRKKDLVKLQAGEYVSLGKVEAELKTCPLVENICVYGDSSKTYTVALVVPQPRLLAELAARLGRPPAPDSPAALADMYADPALEQAVVRELADHARKCGLEKFEVPAAVKLCTEVWSPDMGLVTAAFKIKRKDIQERYKDDIKRMYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQH5</accession>
    <name>A0A194QQH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 102A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQH5"/>
    <dbReference type="FunCoup" id="A0A194QQH5">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQH5"/>
    <dbReference type="KEGG" id="pmac:106718716"/>
    <dbReference type="InParanoid" id="A0A194QQH5"/>
    <dbReference type="OrthoDB" id="5984396at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="43913" checksum="EE66464DDF8EB631" modified="2016-10-05" version="1">MAQSSHGGSHRRSRDPEGAMRYTNTDWEAKEALYQRELDEARARASQMEKTMRWWSDCTANWREKWSKVRNERNKAREEAKHLKNKVDILTKEITTLRSEKHDMEQSLLELKRDNEKLLSIGESRIVSGDLTTDDGVELRRKNVGYVSPSEPSLRQRASLDSHKFSNVDNVLANKLSEMRLRLDETFKNLQSEKDQKAFLLAKIETLTAELHNAKMELTHSDRTLGSTDSSHSEVERLQNELQDEVAAKQVLEEKMAELKMEIERLKSENTIQWSKRELLETENIAILRENKKLYSQVCELREQIHKLNRISDGSAYGGPFTSDHSSRVSSNVLYVRKTSISPRSHESSNGSSEANLAQFDTKTNTSGEEDELAIVEKSENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRE4</accession>
    <name>A0A194QRE4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase PLK4</fullName>
            <ecNumber evidence="2">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polo-like kinase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Serine/threonine-protein kinase SAK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_14548</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="2"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRE4"/>
    <dbReference type="FunCoup" id="A0A194QRE4">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRE4"/>
    <dbReference type="KEGG" id="pmac:106720334"/>
    <dbReference type="InParanoid" id="A0A194QRE4"/>
    <dbReference type="OMA" id="LPSKHWK"/>
    <dbReference type="OrthoDB" id="10004143at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13114">
        <property type="entry name" value="POLO_box_Plk4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000576">
        <property type="entry name" value="Serine/threonine-protein kinase PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047108">
        <property type="entry name" value="Plk4-like_POLO_box_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033699">
        <property type="entry name" value="POLO_box_Plk4_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033698">
        <property type="entry name" value="POLO_box_Plk4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046437">
        <property type="entry name" value="Ser_Thr-PK_POLO_box_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18190">
        <property type="entry name" value="Plk4_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18409">
        <property type="entry name" value="Plk4_PB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51984">
        <property type="entry name" value="CPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51985">
        <property type="entry name" value="CPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 1 (CPB1)" evidence="19">
        <location>
            <begin position="421"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 2 (CPB2)" evidence="20">
        <location>
            <begin position="534"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ06106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="675" mass="76140" checksum="C6DD13022829B2B4" modified="2016-10-05" version="1">MFGEKIEDYELLEHLGKGGFAHVYRARCRKTGLFVAIKMIDKALMASAGMIGRVRQEVTIHSRLKHPAILELYTFFEDAHYVYLILELAHNGELAKHFKLGTHGLSEKAAADIFRQVLSGVMYLHTHNIIHRDLSLNNLLLTKDLNVKIADFGLATQLNGPDEKHVTMCGTPNYISPEVASREFHGLPADVWGLGCMLYTLLVGKPPFHTQHVKTTLNKVINADYRIPIELSVQAQDLLQKLLCKDPTKRITLKGIMEHPFLNSIFNGMNFNKQDLSRDSGFLTTMHSTQHSAKIRAESTKTSEYLGVYKGNEDFLPRDYLENNQQYEVFSGRQNEESVSTFSNKCSNKLCSNSRGSVELLDGRNHMAENNILNSTKKNGSTSSLADSLKKLNMGPGQSNLQAYNIEENKENMVKQCVVKTNSLSVPPLCSERLPTISHRTRNAILKIEPSGVSVEFIKKKGKNREEKVVEICKISKDGMKIIIYSVDKEKDANCYMEHDPSPDEVFSYHNLPQKHWKKYLYASRFVDLVKAKTPKITLYSSLAKCQLMENGTDIDLFFYSGEKATFTSTEGMKVIDKNLKTHTNLAATPELKYLIDHFEECSNRMKRIQLALSSIPDECFPLIIGKRPVHLTPATNVPETASKNFTTPVFNIGSFHRTNSRTTGFSQTKSIDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS68</accession>
    <name>A0A194QS68_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Epithelial discoidin domain-containing receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS68"/>
    <dbReference type="InParanoid" id="A0A194QS68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF580">
        <property type="entry name" value="DISCOIDIN DOMAIN RECEPTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="33314" checksum="B5AB6EDDE9CA2DAF" modified="2016-10-05" version="1">MTRASVCQIYDAQLIQICETDGIEELSDEECPSTGGRRRQRVVVKTLWRGCHNDIKAAFAREATWGAGLKHPQLARVLGLSLLEPPCAALDRGDAAPLPTILKTDKKLNYSSLTHICCQIAAGMKYLESFELVHRDLAARNITVTEELHVKISDYAMFCEEFVTDYHMMADGCRFPLRWMAWESLLMGVYAPSSDVWSFGVTVWEILTYCLVKPFDEMNDDQVIANANEWRRGGRGARVPAAPPPRCRRELYDLMHECWRREPEQRPRFYDLHRFLERMTHGYKPPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSH8</accession>
    <name>A0A194QSH8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSH8"/>
    <dbReference type="FunCoup" id="A0A194QSH8">
        <property type="interactions" value="1758"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSH8"/>
    <dbReference type="KEGG" id="pmac:106717879"/>
    <dbReference type="InParanoid" id="A0A194QSH8"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="138" mass="16000" checksum="347EE07B8E1DC473" modified="2016-10-05" version="1">MSCPIQDVVEEDAADLQFPKEFENAETLLISEVDMLLEHRKAQNESAEEEQEFSEVFMKTLTYTNMFKKFKNKETIAAVRNLLQSKKLHKFEVASLANLCPETPEEAKALIPSLEGRFEDEELRILLDDIQTKRSIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU11</accession>
    <name>A0A194QU11_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_12233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU11"/>
    <dbReference type="FunCoup" id="A0A194QU11">
        <property type="interactions" value="2368"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU11"/>
    <dbReference type="InParanoid" id="A0A194QU11"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121836" checksum="22B5DD0EC4B14E0F" modified="2016-10-05" version="1">MSDPNNPFAGLLGVSEVKPPNDNEYNGDNIPKQINFKKSQEDEDLETVNSMVENVFHFTINNKAIDGPSSDRQLVFLEELSQVIAPKIHIDLETLEQALFERLLLQNVETHVIPKTNRACKEHVVQSQVFPYLFSSLQNLQSYEQLNSATVQNALTKMRELIFRNAITALKQPALFEDQDFSLQLYQLLQHVDPQSHTFFEDLVKAFVAEGGEDCQKQLQDAMIPVLNRITLHVMKSNIINLPIYILPCVHLFASGEECQKQLQDAMIPVLNRITLHVMKSNIINLPIYILPCVHLFASNPNLAPILMESCEPKDETIGRHFQNSVLGALLTLSVLPPKPNATFQFFDGPLDSAGTSMIENSIWNASSHLINNMHKIFLTLLKGGPQMRNRLLTWIGKCLKANVARGKLWNVQATEISGATLNCVSDGFMLNLGAVLLQLCQPFCSTPDDPKSLKIDPTYGAVPPEECAAKSVHLDCLHSETCLLPPREDENNQSIKRPTADTYNFVTECFFMTQKCIDLGVRVCAEKLWRFGQELGRTQRALSDVAPHLLETMRQRGHHLMTKFMSLRCALLEADMLTNLHRFQAMTCTWLVQVAARTDVPAHAGYAPLTLVPIHMPLPAPPPDTLRCIPEFVLENIVVLISMARRTAGAITEEADVVGLLQPALTLVLAFMGDATRTYNPHLRARLAECLEAMLPNHPDDQVPLSNLASFSREQLFKENPHRLQLVPCLLDVFVGIEMTGQSVQFEQKFNYRRPMYLVMEFLWTMEEHRDAFTKLAREAEANMEAVHPPLFLRFVNLLMNDAIFLLDEALNNMAQIRTLQTMQVSGEWETLSVQEREQQLSNLSHIGMLARFDNILGRDTIRTLVRLTAHAPYVFCHPTLVDRIASMLNYFLLHLVGPNKKNFKVKDLKEYEFEPANTVMDICRMYVELGSNERFCAAVSDDGRCYSPQLFSLAETVLVRIGGGGLISSLQEVAGRVAALAVQRRRDEELLANAPDDFLDPIMSTLMLDPVTLPSSRTTVDRTTIARHLLSDQTDPFNRSPLSMDQVKSNTELKERIHKWIAEQRMKIAQTEPSTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVE1</accession>
    <name>A0A194QVE1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVE1"/>
    <dbReference type="FunCoup" id="A0A194QVE1">
        <property type="interactions" value="1095"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVE1"/>
    <dbReference type="KEGG" id="pmac:106716597"/>
    <dbReference type="InParanoid" id="A0A194QVE1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="422"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="542" mass="61577" checksum="3FFB4BC576793CD5" modified="2016-10-05" version="1">MQKAFEIQKNVRDNAKTFQTYLTDLQTWETEMKRKEAALNGDFVKDLPPVRSKIKRERPVEVKKKTEKRISASDYQAWEKFDVEKACEEVDMAEIGPVSLDSKKSEKDKLEKLREEAQYEKERGNAFVKEEKWDEAIKCYNRAIELIQNDAIYYANRGLCYLKKDSLHQAVADCTAALNIDPTYVKALQRRATARERLGSLRAATADLNEVLALEPRNAAAKKQLEAIKIRMGTKGSKSKSSPITEGNNYPQKTPKIVELDNKAVLDKTTPVKTALEKWKTGEGEDINVMKPVKKPPHLRSKRALKTITIEEIPLGKKLSEKPATRMKIIEIDNQAQGDSNNNDNKTKEETKVSEKTNYKIGDGDSNILECMKIKEGKIKDKVDNGDSNITEESLKIKDEKVKDKVGDGTTEKEISIRDLVPPVNSVQFMAEWKNLKGKISARSKYLSIIEPTKITSIFENALESDVLSEILQILSQDMEMFSNKTVTAYLKGLVRVKRFSALAMFLSTSDKQCLNKLLEHCKNVEKCAEEDILDLKNKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVI8</accession>
    <name>A0A194QVI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVI8"/>
    <dbReference type="InParanoid" id="A0A194QVI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000151">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000309">
        <property type="entry name" value="zinc finger X-chromosomal protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="35956" checksum="8930A34481A4F852" modified="2016-10-05" version="1">MSIANVKICPNDGLPSTICKTCTEKVDKCIEFIELCEKSDYILRSNIKSFEKSEVNKEQDYDTENNPDYSNSELENDYICKNLSFSAQERPIEGIDNEKDMSLENKSDISKTENRESGKQQCFKCGKVMSSRFRLKTHLQTHTGERPYSCPHCNKNFSLAQNLKVHLRTHTGEKPFSCTICGEAFAHSAGLTVHRRKHTGQKPYQCILCPRNFRTVGHLQYHIRRHTGAKNFECTTCGRAFITQSDLKRHSITHSGEKPHVCCYCGMRLTRASHLKRHIRFIHNNEKKTQSELPTGGNEIQKVAYSTISVENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWE5</accession>
    <name>A0A194QWE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein 39A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWE5"/>
    <dbReference type="KEGG" id="pmac:106717176"/>
    <dbReference type="InParanoid" id="A0A194QWE5"/>
    <dbReference type="OrthoDB" id="6903207at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="298" mass="34123" checksum="FAAD9800C137962F" modified="2016-10-05" version="1">MFSILEEKLFETEESINIVEKGIKQGILTVFDIIPALPDRLEISVRKLTFEVYPEKWLMLDEKRLKELREHCALAAATHRHIALFSPEVAQLPRFCASEIIWSNGAVPLLSLRMSGRALGPYGRMINGIDYFKIESCQVLMPPVELLSLWNLSAAISGEPRLTFFLLKLMKEVVKGFEEERETWIPDGPEGNNIVNVLYTYGCCMSAIGNTRAAVTYLKDVIRIKDYITDDHFLVPYAMLELAMCYHALGQTESARDLLIDIKNQNFNDSKPLRFLYRLYYKIIMNEEDTTPSPPCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWM5</accession>
    <name>A0A194QWM5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13343</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="432881at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0349">Heme</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="78"/>
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="253"/>
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        <location>
            <begin position="58"/>
            <end position="257"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="28970" checksum="9C2286AE627B7165" modified="2016-10-05" version="1">MDRPSTSRQSIEKVEMFEVREHVPYQAELTRAPAAYDAESGEMYSSSWNSAWQAICQLFNLLHHMQIAIVVFSMWHFALTSSPNGSISNLQLHIIFAGTGYQLFFVEAVLTLHRHNAWSGQLSVDSKRVVHGCLQLIGAIFVIAGTFLGLAEVDMQINTPHGICGVIALVFSLISFITGIIALFSSKVRLMIKTGPVKILHIAVGLFAISMGLITMAIGFNMDYFSASQPGLSTALMVFVVMILLYTIVQPIVDLVTTSRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXN5</accession>
    <name>A0A194QXN5_PAPMA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">RR48_13354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KPJ09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11745" checksum="433DF766B73B7FF2" modified="2016-10-05" version="1">MKLIKTTLDLFINIDKIAQSCAIGCEQDRTSVHSDVRGVTVRMFGIDLRNEWRASQQSDPQSAAASSLLHCSFISGIGNWHHTLPHRNTSLDMTPKRHVENCANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0D5</accession>
    <name>A0A194R0D5_PAPMA</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_15442</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
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    </dbReference>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative dynein heavy chain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1410"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2034"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2861"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ09301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="4088" mass="462407" checksum="6161AB54782076C3" modified="2016-10-05" version="1">MNDTKRRSTITLPAIETIQRNVRQVPTIYSRKPRDIPFHLPHRKLLEKIEFVEKEPEPLTGFAAAQEDRYTRERKSAKIQLEPIKHEEVKKKKAIKIRESRSSMDDERKEEPTADPLKLKPQVASQKEVIDHVRSNPQCGFLYMIYAVHPQNVYFTPYYLKVVKYEDLDRKNYFTISPCGVTHYTSEMVFTKLNDWEQEYTVFVQLHEITFFKVYRYWKALYVWHKSVRFRKYSRLRSVLSRQLFLLTPPLARALLTVQALCCRMLEVSLADTTRHMDTPFFYFNEAQMIRLEMVRRRITEFRSVAHEAVTVAGHEALRLRGFTVDDHEVPPPAIVRGRPVGGMSYTQKANKRKYCERLACFIKLVDYMTNYMLHGLTNRSNAHMANLLRTHASFTPSHDLLTSLDVDTVLEVVPRPVEICKWALFQVDAYVLPSGEVELNPSEKIISEYISKVTEYWDEVVRTFHNFLNDDDLQMFVQPTIMGKQVEWSAGVSPNLYFLMNQDKKMLEDITYIPTAIKEAFGVVDVFLNRMKTFMVEFKAAHEMDLNLIRDERDVNAFKLLCDKLVKQMETIEDVVSYQPLGIIFLNLCPFQELFRPQPRRLFDVVLNTTPDVGRACIDEILEGIESISADISREPETAAELVEFNSLLDGLESRVAFLEERLEYLRELYDFMGEFNIPISPEDMTDYLGLSVALGTLRTSVDARLETRGKLAGQFASQVGRDLMQLMEEVNTLHAQVAQPWLYDDSSDMAKVIEVLDDLMSKLMVCFARDKQIHEWQKIFKIPPSRLDQLDEAINDVKLRQMLWKSSKEWDDHYRSCRLVSLLRHLIHRYEAPFNTLDVDEIQTAAVNYGKQFNQMDKALPPNKIVPRCKQSIDVMKDKLPVISYLRSPALKARHWVRVEEVLHTRFVPGVPLTLADLEQLGAFQHAEELMEIAAQANSEAGLEALLKKVEETWAALEFPVLPHKDSRDVFMLGGLEEVQAALDESCVNVNTILSSRSCGPLKSRVEEWQRNLELFGKTLEEWQQCQQTWMYLEAIFSAPDIQRQLPNETRLFTIVDKSWKDNMRKVAKVPLALPAATQPKLYEELVRNNEMLDQIMKCLEAYLETKRVAFPRFFFLSNDELLEILAQTRNPHAVQPHLRKCFDAIAKLEFGVKLPESEMEVAEDGTLVEREMSPRSRDRLQAALALTARPEDLTTDIVAMLSPESERVNLGKGLKARGNVEEWLGKVEAAMFASVKRCMKYALRDYEMRPRPQWSALHPNQVVLTVSQIMWARGIHEVLSGAEGEDVTTGLAEFERRSVGDLNALAALTRQPLGALFRRVLCALITVDVHARDSVSNMVEKRVQKDTDFEWLKMIRYYWEEELDNCVARMSSAMYIYGHEYLGAGGVLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKAVAVQCVVFNCSEGLDYKMMGRFFSGLATSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKIARLSRFMFEGREIKLVRTCAAFITMNPGYAGRTELPDNLKALFRPISMMVPDYALIAEVILYSEGFESSKVLARKMVQMYKLSSEQLSKQDHYDFGMRAVKSVLVMAGALKRANPDQVEDLTLLCALNDSNLPKFLAADALLFAGILSDLFPGLELPVRDYGVMEEAIKYCLLERNLQIEACQIRKVIQLHETMIVRWGVMLVGPTGGGKTVVLHVLGETYIRLHEQEVEGPQNKPVHMYTMNPKSLSIGELYGEVNLQTLEWHDGVLPLSLRIAVQCTATDHQWIICDGPVDAVWIENMNTVLDDNKMLCLANSERIKLTPHVHMLFEVGDLAQASPATVSRCGMVYVDPREMGVLPYARSWIAGAAAQGLLTGDHPDFLYQMFLMLPEGLDYVTDKCTVGIKQVDASKVAALCSLLGSLLAEPGERFPDKSAARSYLALCYQFCYAWAAGGNLLESFRRPFDEFIKRQFETFEEGEYLPTGMNLFEVYVDTKLRRARPWSESTPPFTYDPDRPFFETLVPTTDTARYGHLLRRWLATNRPTIFTGDTGVGKTCIILQVLNKMQTTDSFIPVTLNFSAQTSSKKTQEAIEQRLEKRPRRALGAPLGRRIVVFVDDVNMPRLDIYGAQPTIELLRQFLDFGGWHDRDKLYWKEIIDVVVVAACAPPGGGRNPLTARFVRHFAMLHVAAPDSSAMITIFKSILGGHMEDFVTEVSSLADNLVRAAVEVYGRVCAQLLPTPARAHYVFNLRDLSKCVQGALQARAAYVRVPREMLRLFYHECLRVFHDRLICVEDKTFFYRLMCDVCEKNFKEPVLELPEGELIEEPPMLLFGDFINPSLPKEMRVYRELPDMEKLMAVLKEYLDEYNASARTEMRLVVFSEMAEHVTRVARVLRAERGHALLVGPAGSGRRSVAALAAHLNDCRCMGMELKRNYDVPEFHEDLVKMYMSAGVALRETVFLCTDSQLSRDDFLEDVNNMLNTGEVNNLLEGDAYEQMQSGCGQDAAKAGVNLSDRDALYRFFINRVRAKLHLCICMSPVGEGFRRRCRMFPSLVNCCTIDWLTKWPPGALHSVARQSLAPLGDAKLINDVSTVCVSMHQDVDVMSERLFTELRRHFYSTPSSYLDLLQLYLSLLDAKRQEIISGRDRVSCGLEKLYSAYESVGAMERAVREMEPLLARKAAEGSALAARLQNERRAADLVRSALLVDEANAKMKADEVRQIADEAKADLALAMPAMEAAQDALKALNKADINELKAFQKPPTLVRFVMEPVCILLGAKPDWDSTKKLLADVNFIRNLQEYDKDHIPDATLKKIKTYLTHKDFNPDTVVKVSKVCRSMVLWVQAIDMYAKVFRVVEPKILKHKEAAGILRSVMAELRAKQKQVEAVEAQLAAMQRELEIVEEERDRLQADVQLAAARLARAGSLTQALANEQSRWENSVKEASLQLIDATGNVLVAAGCIAYFGAFPAHYRRELEHKWVAHCAELKIPASPTFDLVGTAAGPGARLAWQSQGLPRDAGSAENATLVVSAGRRPLAIDPQQQANRWIKNMERENGLHVAKPTAPNLLRILESCVRLGWPMLLEDVGEELDAALTPLLLKQTFIQGGRLLIHLGDSDIEYDPHFRLYLTTKLGNPHYLPEICIQVTLVNFTVTLSGLEEQLLAEVVSLERPELELQRTQLTQRIAADRTLLLDIEERILHLLHASTGNILDDEVLIETLNESKETSEIISARLAEAEITERSIGAARERYREVAARGALLYFAIAQLADLDPMYQFSLSYFTQIFKRVVEEPAKEGDTLEMRVAALVDSATLATQRAVSRALFARHRLALSMLLTAAVQLHSGALPHSYWHYLMHGAGAPAGGMPKKPATEAITEQTWAAVNFLHEHEPAFTGLPDDCLKRIPLNVGEYFVEIHVDKTNTSKPTVDWDKRLSPFEKLMLLKCLREEKLVFASSQYVSLTLGPAFIESPPVQLPTLYADTNSTTPLVFVLSTGSDPFGAFQKFATDKGMRDRVNFISLGQGQGPVAEKMISDAKPKGDWVFLQNCHLAASWMRNLELIVESFTSDQSPIHEEFRLYLSSMPTPKFPVSVLQNSVKVTNEPPKGLKANVKRALIEMDTDFYENHVLEQDWRTLVFGICIFHALVQERKKFGPLGWNISYEFSDSDRECAILTLQMFCAGGEIPWDALEYITSEITYGGRVTDMWDQRCLAAALRRVVSRAALSPEHSYSPCGRYACPRVPLLADAQRYVDSLPDNEPPGLFGLHDNANITYERQETTALLQTIAEVQPRSGGAGGEPPERLVWRICESTRASVPHKVDTSITHESVFAVDERGQPLSLATVLHHERKQYDTLLTLLHSSLRELQRAVQGVVVMSEALEEVFNALANGRVPAMWHARAYNSLKSLGSWLHDLALRVDFIETWWRKGRGASSWLPGLFFPQGLLTGALQTHARRNRLPIDVLAFDFHPTSVFIYQDDIYAFNKHPKEQVDVYSGLEAPDEGIIIHGLYIEAGRWDVPNACLADALPGQTWSWLPAVRVSCRVGAPPAGGRYEAPLYRTAARAGVLATTGHSTNFVIAILLPADHPSDFWILRGTALLTQLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0P7</accession>
    <name>A0A194R0P7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endocuticle structural glycoprotein SgAbd-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0P7"/>
    <dbReference type="FunCoup" id="A0A194R0P7">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0P7"/>
    <dbReference type="KEGG" id="pmac:106714762"/>
    <dbReference type="InParanoid" id="A0A194R0P7"/>
    <dbReference type="OrthoDB" id="6379191at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264807" evidence="5">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="16912" checksum="C1842A88890ADBA0" modified="2016-10-05" version="1">MKSFGALLVLVAMASAAPQFQYQQPQYQGQQIPILRQTQEVNFDGTYQYSYETGNGIAAQEQGYLKNAGVKDAEAQVAQGSYSYTSPEGIPIAVSYIADENGFRAEGAHLPTPPPIPEAIARALQYIQSRPQQPLSEVRSQRNALYRSRQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R126</accession>
    <name>A0A194R126_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R126"/>
    <dbReference type="STRING" id="76193.A0A194R126"/>
    <dbReference type="InParanoid" id="A0A194R126"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="219"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="444" mass="50103" checksum="2C0ABF41A23DA1CF" modified="2016-10-05" version="1">MNLKDNDWLELFVIYKIVIVHRCRNVTTGCYTGALNMMWKYQLLLCLILAIKTNESYKIDFEQSTKTVILDEIGENLNGKFQLKDFGNNRDTKKLPAYTSWSAWSECQGGHRTRRRHCLRRGVCGDSLRVEVARHNCVITKTYKNSLGVFLRGAPGVFVHRDVPPLDGEYTIAETMAPPPKAIHPEDTRASTQVPPCGQLGRQRGHARTRTRMRDMLRIIGGRPAPPGKWPWQEAFCGGTLVSLWWVVTAAHCVRRRLLVRLGEHDLFVRGRSELEMRVVGAVVHPNYDPDTVVNDVAMLRLPAPARPELGHGIACLPRPGQVLPPHATCTILGWGKKRATDAHGTRILHEAQVSTVQQGVCRRSYWQYAITDDMVCAGRGRRDSCAGDSGGPLLCRDRTMRYYLQGITSFGDGCGKRGKYGIYTRTAGYVTWMRSVMNEKYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R131</accession>
    <name>A0A194R131_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_15051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R131"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1920"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2084" mass="232772" checksum="EA77659C8F0B56BA" modified="2016-10-05" version="1">MQPKILYLFTACSMENITNWLLPVTTNIYDTERDVFFRRSTTNIEGINSVTNSEGLNGGPYLTVSYSNSEFTIAPNAQFENYEENETEHSIGITVNFRCSGGSSNTLIFIINIIDTNNNAPQFRPSDNYHYKVAPPLPPGFLITDCVSNLIVRDIDLTTQRIDFEIEENPFFEIVSDTSTTPKEFKATLRTTTFIRRISEPIVLWIKATDVDLTGDPPITSNATVHIEADTEFEFPDELIFSQTFYIATYTIEGNILLESDIYLQQGYDASVSFTLEGDNKDLFDINVNENRITLRAVSQLPTDLLTSQIYLILKASREHTSGATATIVVNLPEGPNLRFEDAYYTGSIVDNSLRIQDLVLKENSDYPVQLNIYSEFSQYFTASVQNNNVILRMDPLNDEIIKNNNILTLQIVAIANNRTAATVVVLEIVKDDLTTPIFEKNIYNATYDPILGVTAENITFIQGFDETVTLSLEGDFKNYFQIKQDGNIFNIITTGLPSHVLNEQRLLLTIIATKPRTVGAQAVLYIALPQARALAFKSLTYSGFLVNNSVILETIELYTGYDEDVAFDLSGDYARYFIQSNEGHLITLSVSDQIPESVISDINILILTLTAEGNGTETARTTVVLEIIKQDTTTPMFNKNIYHGTYLDAATMSIENIFLTQGYDENVIFRLSGDNAQYFVISYNGNNNISVSLDTIIPEELIFNEKVLLFNILAEKNFSVGANAAISVNFPKELTEPVMMRFSKNSYTGNITNEMLTVETIVLDEGFQSQTEFLLNGDHASLFNVTNDGNIVTVQQNEKLPEEIFENKKIIILNIEAIRPRTIKAHATIVIEIISQIEPTIIVPVFERAYYYGQYSVEDKLQFNQTIQLREGYHENIIFELEGDSSVWFSLTPLDDGVILTLQSSIPSEVLANNQQFIFIVTATVFNSTISARSTIVIAVINDVEEIVILDFNKPNFFGTIDNNTLDMESISLVQGFSPDVVFTLQGELASFFYKVINESTVKIQLKDMIPDSVVPNNRIIILELVATAPKAVPAYVTIVIEVVRHEIPSLNDLLKFAEAYYIGAYDLTDGLYFNYNITLAEGNDETVEFTLVGENSLWFGVVPTESGVTISLTSPIPVDVINNNRQLIFEISASKPSSSVTATSVIIITIINELNTTQILSFEKNNYLGTVDNITVNLEPIILVEGFTTDVQFLLNGELANLFTKRIDGAMVYILLEDTMPEEILSGNRVIVLELEAKASEALPSYTTIVLEVIQQNHLPVHVLKFKEPYYTGRYKENDVFEFDQAIALTDGSSNGVEYSLEGDNAIWFSLEEVEDGLLVILSTPIPQNIQSENLFLVFIITATKPESVTARSTIVISLPNASHDNNIYFNKLLYRGVISDNVISHENILVSGYNGTDVEIFGDHVNLFIVQINQGVVTVEMRDTTAVGVDNTYVILEIRVPGAGCVLQLDVIAQEIPALPTVRFSSELYVIQVDISQTGLIGQVSATADNGESITYSLSLDNEQLKERLSINSNGQLHLKASVSSGVYTCRVVATTDITQVNGTATVILVVESGEEIGLPPLIIIEKDEESPYNNLVTLNRSEDCRYEMTNRWPIDQTWLYVDDNGLHTNAIDREHKSIAFMALSQIQVELTLQCDYDVLTVRSNRSFNNIPMTKSLGPYDYGTYRWVLTDPILYDPRRSFVNLIVNDINDNDPIFELKENEPIAVGYPLSELEEIVPPRALVELTATDADIGENAALVYWSSEPALAVSPTTGRVHVSNSSLLQHGAILRVSATDRNGVDGRTGHIDLMVRLLDVHQIAVVTVQGAFLEDENKVLTNLTNALGYDVKALRSVILPMDSDTRTNENTSRRERAAVVSTGAFLRLFIYGLINREPVEVSRLTSDINSIVMGNIASTVSLEDHLESREICSLPARDTSLLAATIALSILLFIIIVLSGVWFFLKWRNTYNYNNFSDQNSLASRDQIPPTVKIEEPAKPRMNIEELKRSERRLQDILDAPKTSTQNDNQTETVVDVPTPDQRMPIVIQSIDKLKDAAETSDDEDEFGETQTARRKSVVTFNENVEKIIHLEDSPSDADYEVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1I0</accession>
    <name>A0A194R1I0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADAMTS-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1I0"/>
    <dbReference type="FunCoup" id="A0A194R1I0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R1I0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF305">
        <property type="entry name" value="PROTEIN MADD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLAC" evidence="6">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="625" mass="68033" checksum="6E84D7A8C2DFAC06" modified="2016-10-05" version="1">MVKAKEMMMMMVGAEVVGRESVLASTANRELRCGRRLVSGLFTRPRLPLGYSHVATVPRGACRLNVSEILPSDNYIALRVTNGSYIVNGDFAVSAPGTYEAAGARFLYSRNAGLDNVFAMGPVHQSIDIMVLYTQPNPNIKYEYLTDSPPDDTSNDIPTTSIHHQNARHHRHHADSHTRALDKSEPSLAKQPEFSSVESQYQIDSNVIGDRKFIWKVVSFTQCTRTCGGGLQIGKYKCVEVGDKDREVSPAHCSGSSPPARRRRCGTAPCPPRWRAAAWGPCPVCGPAHRTRIVGCVQDHARGITKISDQKCPLPMPPSSEPCDIPNCDGTAVKTNTEARQDSRRQVRPKDRTETFREGPVVSLAANVTENEVTPTMDSSSFSYSAPGGWLYTEWSECVGWCVGGGVQSRGVRCADPTGCSSHRAPHMSQACSPKKQCDAQWFTGEWSPCSAACGGRQVRGVICVGGNGRRLRDGSCRTPRPEADRACGGTCAPSWYLSDWGECSGPCEAGIQSRTVWCLRGGEAGASGAARDAACAGFRPPARRSCVPPRCTTTPELKPAVITPVSDPQRVTRHQSHNTQNFKERSPVQGACADKLSNCMLAVQARLCHYPYYAYYCCHSCHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1X3</accession>
    <name>A0A194R1X3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Periaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1X3"/>
    <dbReference type="STRING" id="76193.A0A194R1X3"/>
    <dbReference type="InParanoid" id="A0A194R1X3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264855" description="Periaxin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="39665" checksum="A624D6EA06C9F201" modified="2016-10-05" version="1">MSELIDNHNGYNQVQVTNHLQLWLVLALAASLAVPVKDVANDSEAARSKRSPSGWHSEPEGVWKKKLVWKEDWKQIWKTEKKLIWKTEWKKEKVPAWKTEQIQQWKEEQVPDWKVVQKPIWKEVQVPIWKEVQVPDWKKVWKPVWKEIQVPITKDVQVPEWKQSYVPEWVKEGIPGEKFLGKDNHGWEYTSHDLWRKKMIWKPIWKKVWKTVQKQEWVTEKKLEWKEEWKQIWRTEKKQAWVTEKKQDWVEEKVQVWKTIKKEIWVPVQKKIWVEKWKQIQVPVWKTIEVPAWKKVWKPVWEKVWVPVHHEHHEHHEHHGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2I0</accession>
    <name>A0A194R2I0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SH3 and cysteine-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_15094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194R2I0"/>
    <dbReference type="InParanoid" id="A0A194R2I0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20817">
        <property type="entry name" value="C1_Stac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000056">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="28169" checksum="4D5C9D2D85FBA5BD" modified="2016-10-05" version="1">MEHPYTVNYSTNQQLLNSNDYKFKRIIECTRELFAAKADSSSAVDRKLSTSSAGSMKNKWLKAFRSLKPPSAPPPHPGPQDKRNGAARDAMRSGAESEAHNFQEYTYKKITPCDVCSQVLRGHTRQGLRCRICKMNVHTDCMPQVGKCQTKSRLLRRQKSTSEIESHRVQDTAFDEERAEDGRLPGHRLTKICFKGSVEFDDDFDSYYDEESEETTTRPFGQPLCFVKENGDPPPSILKPTASVRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3I5</accession>
    <name>A0A194R3I5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthetase domain-containing protein CG17486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3I5"/>
    <dbReference type="FunCoup" id="A0A194R3I5">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3I5"/>
    <dbReference type="InParanoid" id="A0A194R3I5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="161"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="423" mass="48445" checksum="954EE8636EFE9439" modified="2016-10-05" version="1">MQGTIPVKQPLENNNGVLLFNGDIFDETWNSGLNDTEIIMDKLSNHVGRNYNCTEIPAGNIQKLNLNTFEITLYNWQYDTFERQCPLEDWLEEIQNQQNLPDDKFTFDFDSNLDLTDEENIIQTIESEIRKNNDKITLMRNLINIESIKNVILRITDLLEKIGILFSGGLDCTILALLADKYVDKDQPIDLINVAFGINENSTFDVPDRITGRQSYEELKSVCQSRKWVFKEVNVPKDVLEDKQKSTIADLVFPRNTILDESLGSALWFAASGYGCTSSCRVLILGSGADELFGGYLRHRKAFQRQGWLGLSKELQLDWNRISFRNLSRDNRVICDHSRQPRMPYLDEDFVNYILSLKPWLRCFPNEALDCGVGDKLMLRLVSLSLGLTNVVTYPKRALQFGSRIANKKQKGGDLSKNFLDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4A5</accession>
    <name>A0A194R4A5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tyrosine-protein phosphatase Lar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_11610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R4A5">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4A5"/>
    <dbReference type="InParanoid" id="A0A194R4A5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001219">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001000">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001015">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="229"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="326"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="421"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="789"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="964"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="1250"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1341" mass="153138" checksum="CA8881709F4EDE84" modified="2016-10-05" version="1">MLKGVLRRRGPKYSISIADCGNFVPGEPQDVKVTTINSTAVHVTWKPPQEKEKNGIIRGYHVHVQEIREESKSLLNEPMRFNVMDDTILELNVSGLQPDTRYSVQVAALTRKGDGDRSPPVTIKTPGGVPNRPTVNLKVLEREPIVSIELEWTKPTQTYGELQGYRLKYGIKDQKLLEENFGIKVNSHRLTDLERGVQYEFRLAGRNHIGYGQENIKYWLTPEGVPKGPPTNVTYHFQTPDIISVTWEPPIRADRSGQIKKYDIQFYKKGDQSSLVEKTKETTKAVFTGLEEDAHYVFKVRAYTDQGPGPYSKDITAHTERDIGRAPMSVKAVATSESGIEVWWETVPSRRKVIGYVIFYTMTPVEDLDEWQQKTVHVTHSADIENLEKFAEYAVAVAAKTADGLGRLSEKVTVKVRPEEVPLHLRAQDVSTHSMTLSWSPPLRLNPVSYKISYNAIKEFVDSLGMTQTQEIPKREIIIKHDKTSHSINDLSPFTTYNVNVSAIPNDDSYRPPTKITVTTQMAAPKPMVKPDFYGVVENEILVILPQASEEYGPISHYYLVVVPDDKLHNHKHPDQFLTEDLIKNNARADDENAPYIAAKFLQRNILYTFHLGNNESYEGFLNRKLNPNKRYRVFVRAVVDTPQKHLYTSSPFSEYLSLDMRGAPPGEEPSRPDPKDINGDPEIRIEENRKEAGMLWVIGPIIAALMLSLCLVMLFIMKRRRQPCKTPDQAAVTRPLMSADVGFGAPSDPVEMRRLNFQTPAMISHPPIPISELADHIDRLKANDNMKFSQEYESIEPGQQFTWDHSNMEVNKPKNRYANVIAYDHSRVILQPIDGILGSDYINANYCDGYRKHNAYVATQGPLQETLADFWRMCWELRTATIVMMTKLEERTRIKCDQYWPSRGSETYGTMTVTIAEVQELATYCIRTFQITRNGGTERREIKQLQFTAWPDHGVPDHPAPFLQFLRRVRALNPPDAGPLVVHCSAGVGRTGCFIVIDSMLERARHERTVDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVICGDTEVPARNLHAHIQKLMRVDTIENINGMELEFKKLANMKADSSRFVSASLPCNKHKNRLVHILPFESTRVCLTPRDGSDYINASFVDGYRYRAAYIATQGPLPDTTDDFWRMLWEHNSTIIVMLTKLKEMGREKCHQYWPSDRSVRYQCFVVDPIAEYNMPQYILREFKVTDARDGASRTVRQFQFTDWPEQGVPKSGEGFIDFLGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSTVLERMQYEGVLDVFQTVRTLRTQRPAMVQTEDQYEFCYRAALEYLGSFDHYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5G4</accession>
    <name>A0A194R5G4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3">Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5G4"/>
    <dbReference type="FunCoup" id="A0A194R5G4">
        <property type="interactions" value="2402"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5G4"/>
    <dbReference type="KEGG" id="pmac:106713214"/>
    <dbReference type="InParanoid" id="A0A194R5G4"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="515"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="836" mass="94549" checksum="0FD2E96AD2CE8FEE" modified="2016-10-05" version="1">MSALLTADWFHLDSYYRKFDLYTMVWSMDEGLGTMVVSGAPYGGPIAVVRDRKQFVQIATIVKPVITIYNCVGNVMSKILWNSGVLIHMGWSDAEQLLCVQESGDVLIYDMFGAYQKTFSLGQEVRDTKVCKAQLFPNPHGIGLAVITSTNRMFLVSNVSDPKIRSVPDLPRANDPISSWCVLSSGQRSGSSMIGFLVCRDKEIYKCQLGESVAVLMRPEIQNAYTQILTIVPSQNGRHVALFTDSGILWIGSSNFKTKYCEIDTGYFKQPKELVWCGSQAIVGHWDDMMYVYGFNDTVVSYPYDGPFHIIPEMDCVRVISEMTHELIQKVPDVVDKILRINSTAPGCYLLEASKQFQKRSHRADEYIRLVKPDLANAVQDCIDAAAFEFSPDVQKMLIRAAQFGKGFILDPVLTDHYVKTCRWLRVLNSIRDPKVAIPLTFFQVQNLGERILLDRLIWRRLHCLATHIASYLQLKDGQTRVLSHWACYKVTQPHLDNESAAREIGEKLRNVPGISYATIAMKAAEKGRKALAIKILEYERSRALQVPLLLALGEGGAALRRACAAADTDLVHVVLLHLKDNMSKHDFEMTIRGFPLAQALYLKYCAGHNREALRKVLVQEDNFPGQAATHIRDAIDSTNPGSVEASLISARECYKKAKNDLGVSICEELRKLCKQQSSLQETYGVSFLGLSLHDTVKRLLDQGEVKLADKLRSEYKMPDRRYWWLRILTLAERHDWTELDRFSKSKKSPIGFEPFVDACLKYDNKDEALKYLPKCRDDIKVKYYVKAGFFEEAARVAFEQKDKSALLFVQSKCPLRDSSQHAAIAALLEQLNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6D8</accession>
    <name>A0A194R6D8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6D8"/>
    <dbReference type="FunCoup" id="A0A194R6D8">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6D8"/>
    <dbReference type="InParanoid" id="A0A194R6D8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="718" mass="78831" checksum="3C2504E46FB33125" modified="2016-10-05" version="1">MGICLDTEQNNEEQDRETESYGGSRRGRESAWGRTTPPAAAFPMQNSSHVKFEPPTVPVIFVLGGPGSGKVTHCDTLAQERRGLVHVNMTDLLQQYAIGNDMQDFGSLSSRTVTEVLMLEMKMAPAAAAYLVSGYPRSMRDLAEYTDKIQTVNGAVVVSWRQRVLERQIEYGARLGHVVLSLARMELAHFYRHVVPVADYFDHTGMLIVKKAEMENISLAALLSDSTEDDDSKKLTLRMSSESDTSNTSNTSANTSANTSADTSVNTSHDKTGPKRTNTTDEQVITVVDASNNNISCTNRPARPVKYHDHTEDWREVEVNGERNPEEVYKDFRAAVLKILGTAEDENINGVSGVGPDGIPGEIVGIEPAPMGIRGRSVRSQISPDGRRLGPDVRGGQEPVVVDESLPAAVPVVLPVNGNVERIVSPKTKVIRVRGAATRACVVCVVGGPGSNKASLCQRAVAHANGWTHYSLGQRLRSLAESGGGAASDGALCRAAVSGGELVSNELVGRLVRAAVSDAARTGHGLVLDGYPRDLQQLDVFEKEFKISPRMVLVDCSKLQLGRGRRDDSVAAFRRRLEVFRELSLPMLKTLDQQHRLVIFKISPRMVLVDCSKLQLGRGRRDDSVAAFRRRLEVFRELSLPMLKTLDQQHRLVIVDGDTDSAEVQEEFTRVLLEEMEKAEALVSMPQNNHDTITHQPGDNIDKKSWPMRGSNPRPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6F7</accession>
    <name>A0A194R6F7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heterochromatin protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6F7"/>
    <dbReference type="STRING" id="76193.A0A194R6F7"/>
    <dbReference type="KEGG" id="pmac:106712785"/>
    <dbReference type="InParanoid" id="A0A194R6F7"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="21582" checksum="0D78A71F7E57FAC0" modified="2016-10-05" version="1">MGKKDKKGETTDPSSEEEYIVEKVLDKKIVKGKIQYLLKWKGYREDESTWEPVENLDCEELIKTFEESRKEKEKSKKTEERGKKRVRESSVETTGSGRKGRGTSVSSVEDPKENKREKEQKSGFERGFKAEKIIGASDATGELMFLIKWIDSDEAELVPAKVANVKCPQQVIAFYEERLTWHTPAESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6Q2</accession>
    <name>A0A194R6Q2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6Q2"/>
    <dbReference type="InParanoid" id="A0A194R6Q2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="11019" checksum="8AAC5EAB8FB995A1" modified="2016-10-05" version="1">MGVVNEIWLNVQFILGMHVMYPESWVQDRSSQPLSQQQAGSPYNWAHPTKKRPLSPHTALYHSGLVQPDHTIYKVSVTACLKSQYASTNKVLRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7L6</accession>
    <name>A0A194R7L6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exonuclease mut-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7L6"/>
    <dbReference type="FunCoup" id="A0A194R7L6">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7L6"/>
    <dbReference type="KEGG" id="pmac:106712125"/>
    <dbReference type="InParanoid" id="A0A194R7L6"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="382"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="836" mass="96263" checksum="F74175D0F3AE85B4" modified="2016-10-05" version="1">MNTNSLTNRSMKVVPTLEETLKSIGLNIKLDENVQAWFNQLTITWLTWKRSPSLEHHLQVFFDTNPDRYRIALVFVAKCKDSKDCKPKTLPFFIMENLHKWSCKNDTSPEDCLKFPAFRIATEQRNQQYLNLIVKTYKIITIKETILPLVKNMLKNDNCKQASQVVLAMELYEDIPVEDLLFPLIIQDKYNMIIEYLSECPNQVLQLVLFLDKILDKNVSIRDLVQKYIYEYNITCVNYEKLHHKPLGKFVGRLCSKFNIPIETCKNLCRNRTLGGLRYLIHQKYVDHNVSLTVWDDLIKDTLKENSELALEFVYMIVNHDKKEAAKWSQYFNLPDTDLPQSLKKMSLDAVSSVENENWDDDDGDENPNQNFYEISLPADRIIIINTPEMLYELTNTYLVDCNLVSIDSEWKPSFGAAQSHVALIQIAVENYVYLIDTLALNKPQYSSFWYDFNKSLLDNAEIIKLGFGLEQDLKQIKGSVVGLNNIKVKGEGLLDLSTLWKNLISSGLSLQSSSGTVGNSLSSLVEICFGYPLRKSEQRSNWEIRPLRETQIQYAAIDAHVLVELYNFLQEKCLEQDINFEEICNDTMIDKKTKCVKQLKYSEKTPTGSAIKAKSVDDVKFFVEGKLINYMPYLRYYGIDTLLIPETLLWHDVINQAMFENRYILLAKLKCTPMKTYPQSSILDVGNGYVTKEKLQKIQNYFNIHIKESDFTKRCINCNGLDLEKLTSDKVSKLCSQYQNVSSVSSNVNYTVPTDHDYYEKCDKYLSDSDDDDIVCTPTHNLCVTSTGVAIQIQNVQKLSQSPQAAIICNFCGRLFWDGDDLYKTVMSVANSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R882</accession>
    <name>A0A194R882_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cAMP-responsive element-binding protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R882"/>
    <dbReference type="FunCoup" id="A0A194R882">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R882"/>
    <dbReference type="InParanoid" id="A0A194R882"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="17877" checksum="0B355E232C99B90B" modified="2016-10-05" version="1">MKIKPRPKFVVFLLAIYNSFDVKKTKSKLISLVQESLGGGVYGSTGASGAEGGERREGGKRGRRPGRKAQLDKQDMKAKLERSRQSARECRARKKLRYQYLEELVADRERAVIALRKELDKYYKWNLELDQGRMPEGLEAVIQELGVDKQEEAKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8L4</accession>
    <name>A0A194R8L4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8L4"/>
    <dbReference type="STRING" id="76193.A0A194R8L4"/>
    <dbReference type="KEGG" id="pmac:106712142"/>
    <dbReference type="InParanoid" id="A0A194R8L4"/>
    <dbReference type="OMA" id="NSYFDHK"/>
    <dbReference type="OrthoDB" id="21443at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="36298" checksum="F95078B6CCAB6946" modified="2016-10-05" version="1">MFESDDFDQVLSQLDIPDIPTKTSINNFSNLNVNILQNNSTEIISQGNAVLESNYNNNKTINNKGTESEVNLIQNNNNLLSPKHCKRKIINSHFDSNCKRKFPGPAGLLSGTFKEYKDENIDHIELLSQDIDFSQNPLHRELFESSLWKRLLKDVNEWKLNSVETIKTIQQFALNGNLKRRKAQTITAFVECVDRSAMDPLVTLRDLTGNIKCTLHRDAWSYFSPYIVPGHSALVLSKPTILTTGGAFKKHYLNITMSNILAIYSSVHDKDEQMPDGYQKICNEDCTIIKMEKQISDETQVYSNDYNDLDSIFSDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAY1</accession>
    <name>A0A194RAY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Major royal jelly protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAY1"/>
    <dbReference type="STRING" id="76193.A0A194RAY1"/>
    <dbReference type="InParanoid" id="A0A194RAY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="20055" checksum="979AAF9B1C403252" modified="2016-10-05" version="1">MYSVAIAVFRVNLEYSGFIGDITHVDIVDYVDTVDFVDFVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFVDRIDSAESVDFEDSVDFVDYIDSVGSVDFKDGVSFVDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBR3</accession>
    <name>A0A194RBR3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod PDH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBR3"/>
    <dbReference type="InParanoid" id="A0A194RBR3"/>
    <dbReference type="OrthoDB" id="8178425at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009396">
        <property type="entry name" value="Pigment_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06324">
        <property type="entry name" value="Pigment_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265073" evidence="5">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11198" checksum="166BB3DBB4B092CB" modified="2016-10-05" version="1">MRTAWRTLAYVMIVALLPQVSLYNIKTDVNFTPYLVNKEYVRHIHSMVNAYSNRGDGAGRLVIETNALIDTKYRTWKRNADLINSLLALPKGMNEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBZ0</accession>
    <name>A0A194RBZ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBZ0"/>
    <dbReference type="FunCoup" id="A0A194RBZ0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBZ0"/>
    <dbReference type="KEGG" id="pmac:106710705"/>
    <dbReference type="InParanoid" id="A0A194RBZ0"/>
    <dbReference type="OMA" id="DVAYWCH"/>
    <dbReference type="OrthoDB" id="184109at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="178" mass="19824" checksum="DA96303031037CB7" modified="2016-10-05" version="1">MAELHLLGDIQGVTNFEDSSSLFCRFSFQAGPNWTFIAGCSEGQTTSGKPNHDNYVFWSHPIDIHYVTKGISGWPKINFQVSCLDSLGRSWIVGYGCCSIPTAPGNYAVKVPCWAPAPTTITDRIRQYFLGGSHQITQTDVISLGVDRYKLTTQSKGNIELNIDVIFRNFTQFGVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDJ5</accession>
    <name>A0A194RDJ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDJ5"/>
    <dbReference type="STRING" id="76193.A0A194RDJ5"/>
    <dbReference type="InParanoid" id="A0A194RDJ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="434" mass="47006" checksum="59A8910D55CBE651" modified="2016-10-05" version="1">MVLMGAVCSVDVDFELARVGLLGILQPNRRQRLSLHIAVVLLAVYHTCKADLARRDVSSLYNQNYGVLGAPIDANLNEDGYFYPKPKIPFPPPPPPPPPSRPPPPPPPPPTRPPPPPPPPSTRPPPPPPPPPTRPPPPPPPPPTRPPPPPPPPPTRPPTQPPTYSTQLDDTTMTTRRPPPPPPPTTRQPSTYLPPFTSTRLPPPPPPPPTRPPPPPPPPPTRPPPPPPPPPTRPPPPPPPPPTRPPPPTRPPPPPPPTTTRPPPPPPPPPTRPPTTYLPPQTTRRPPPPPPPPSTTRRPPTYSTSKTTGYDYPTPSVVFTLPTRPPTQPPPSPSPTTRPPPPPSPTTRPPPPPSPTTRPPPPSPRPTSPTPGYTYPTPSRIPFTTRPPVYITPPTTQRPIYIPPSTTKVPYTTRPPFVPDQGYYYDRPKVPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REP2</accession>
    <name>A0A194REP2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Circadian clock-controlled protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REP2"/>
    <dbReference type="InParanoid" id="A0A194REP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17354" checksum="6A81196FE01B2360" modified="2016-10-05" version="1">MQIAFPYIADGISEIGVPRTDPMNFENITMWTEQNSFRFTLPYLQIRGGRRCKVVEFRQLRDQSALKLIVDCPLLGTGTYKLNGKMLIFDIDKEGDYKMQTIQPLMNVFSKDKTTILQIGEPIESSIVKNLFNALKVFFNRVPIDEFLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REU2</accession>
    <name>A0A194REU2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REU2"/>
    <dbReference type="STRING" id="76193.A0A194REU2"/>
    <dbReference type="InParanoid" id="A0A194REU2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="49999" checksum="B86FE32B98C5CFB9" modified="2016-10-05" version="1">MQVIKQPLTQRVEQYMEGLLSKKAYDHPSDSVPLEKLELTLPDWYDERLFKKGQRFFWKHCFGLSFVMMPGLVAVFAVPTILEVLAGSGKSSSNYTAFKRYVATFLHFQSWFTYDLKPDSVSWRSLYAVRSQHLRNGRAARLKNKGTISQRDLALTQFGVIGLGILKPERFGLRQEDPEDWEAFNHLWGVLGYMLGLEDKYNMCRRTMDETRQVCKLILERVYTPCLENVPEYFEHMARVMMDGMWAVNGATEAGSLMYITKNLAEVPGYVYTEAERIALQAKLKEKLSGKNENTGVDVSTLIQKCSVEGLPDLPPRLLYLKDYDSWDTIPEYKKLCYGSKYKLAMLSLFMAFYSTYFGRLVLNLYYKMTMFLAEYFPYVAFFLYGIKKSYVDMFKDPEYDNTKNIPNSEYYKPQPPEPWYRLLLSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFX7</accession>
    <name>A0A194RFX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Negative elongation factor D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFX7"/>
    <dbReference type="FunCoup" id="A0A194RFX7">
        <property type="interactions" value="1386"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFX7"/>
    <dbReference type="InParanoid" id="A0A194RFX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="436" mass="49021" checksum="6C7AB873BA3202AF" modified="2016-10-05" version="1">MIEHPTWRSLIYRLAEEYPDCLMLNFTIKLISDAGFQGEITSISTAAQQIEVFSRVLKSSIVGFLQSSDDWQNSVNECAKMVCHGAQTYVYSQVIVHILSQEPRGGAIMKRLGQEITRCAQQSGHDVTPITLALTPGESWRGARTALAAMLSRDALNPADISVLFRAYTQPEPPPVHLLRIPQFLELLVDSLFKSGSKLNPEHKSKYMYLLAYATSVCEGVTPGRPIKEELKATVQAIEKIHTVCSSSASSSELIAELPTLYHCIRFPVVGMGVLVWVECVVTEPSYFKLCTEHCPVHLALLDEVASCHQLLHHRLLRLLIQLFESPQDELEILVQLELKKMLLDRMVNLLSRGCVVPVLRYIKQCWQRGDTDISLIRYFITEVLDAIAPPYTQEFVQLVLPMVENEEITGTMRAEGENDPVSEFIVHCKAHYVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGM4</accession>
    <name>A0A194RGM4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Brain tumor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGM4"/>
    <dbReference type="FunCoup" id="A0A194RGM4">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGM4"/>
    <dbReference type="KEGG" id="pmac:106708917"/>
    <dbReference type="InParanoid" id="A0A194RGM4"/>
    <dbReference type="OMA" id="PICNECL"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="648"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="870" mass="94346" checksum="1C598D3BE40B50BF" modified="2016-10-05" version="1">MEEINGDIYGDGLVSLGEDGSLESPDNGKQEQNCKICDNKLCSPRVLSCLHVFCEACIDKLMVNEAGDSLKFDLAVECPLCKQETKMPGGGAASLPSDYVLTNILDVSSMDQSVVCTCCKSKEPAVARCTDCSHFLCSNCNSAHEFMRCFENHRVVPFDALRSSKEKSAVHKPIFCIRHVGESLKFYCCECEVGACTECLTVDHKVGEHRCERIVDAEPNLRAELRNFIMQANARAEAAGSASSKLDDALGDLQRQRDEAEGVINEAYRAYKAALERRREKALEELERLHKERELKVMDLFDRVDKTVQRIECACKFATRLLRRGDGTEIVMLKKTVASQFARLLEGSPEFDIDYSLEFVTKLEKFDAITEETFGTFRTETTRAEERKRACEVSSIMPVPSNTHSPAVSLTNAPVFDDFPLGNVRRVTGVSGHGGLVGVPGVGGVPALGVPLPGVTNTGVMPGVVNVNSVTGVGAVPGVGGVSALPSMVEYNLQQLASIAEKDVQQTPHASPAPPFTLAELLAGDLNSPQAYNNLQALAKLGLNTEVNGFGSVGGVGSIGPVGPRGVSPGRPLLTAAEEAALVAPPAPLVRATKATPMHIRFKFGQLGGGKGQFNSPHGFCLGNDEDIIVADTNNHRITVFDKSGNHKFNFGVAGKEEGQLWYPRKVAVVRATGKFVVCDRGNERSRMQIFTKNGHFLKKIAVRFIDIVAGLAVTAEGLIVAVDSVTPTVFILSEEGDLMSWFDCSECMREPSDIAISGKEFYVCDFKGHCVVVFDDEGRFLRRIGCENVTNFPNGIDVSDAGDVLIGDSHGNKFHVAVFSRDGVLVTEFECPYVKVSRCCGLKITSEGYIVTLAKNNHHVLVLNTLYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH48</accession>
    <name>A0A194RH48_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pro-interleukin-16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH48"/>
    <dbReference type="STRING" id="76193.A0A194RH48"/>
    <dbReference type="InParanoid" id="A0A194RH48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="773"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="894"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="986" mass="108619" checksum="48A940AF1B1F7330" modified="2016-10-05" version="1">MYTKRIIVLDTKTYSIVKVRHTHFLHPIEEEKEDRIHKSDAEDKSLSNDETPLPTCPRQPPDGVETPSDAVDKAPDLPTRLPPRLPPALYTGTTRPRLSYLSRTQDARSEASVKDKIAMFSNDLATSSDRLDKCGTLPVRTKSTLRKNTPSYSNSFSEVSTLDRRLTKSTDNLDDTPRSYKRHTDRPEVLGALEISNKEVKNSRFSHSELTKMPLFYGSTTTLPSSVDASFSRSVYHSRSVSDDTSNKNVTAHKLEHIIEQRKKSLSKLRGLVIPEVHSQIIDLPEIKVKDSISKPFILKYNHNDTYKKDNLTMTRSLSVNENKWKTNFLPNNIPKYSPAFKRKSLQVYSPSSLSKESTPERKLIERIDVQNKTYNKPSLAKSMRSTLESGSLLQSPIKDYKNTLGDIRDYKNVEIKICTTTEIVDSDNESALSSAQSSYRSSASSPMHHVDAIESDSSRLSPRISNYTSYSLVKSEISSKSSNAEKNCEEFIKRKVCRSVSSDTNISLSSSAGSAATSGSQASCSSLESSVADSDKRKVSKVYNVDTINRRNILASAKCRSGRDINLKSPVVETKFSHESYNRSPSPTLKSSERLSTLTSSVSAITNKGETRRRNKVIAESDSDTDNDTHARNRKTEYKASRLKRNSSISNKSKQHENSYEPSKVEEGSKLSKEKNIQESKKANSEYSNEHKSNNLATYTQSVQRNNDVQKRKEIETITSKKTVTSNIDAVDNVKPLLAYEKSDMIINKKEEVSSNKIESKSNDQHKISTSIIRLKKAVGSGVGVILAGGTDCEAKDVTVHRVLADSVAAKAGLKRGAKIKAINGCTMTGLTHAQSVTILKEQRSEVIIEIENETAVNDSKTGCGSEKAESKDRQKRDEVSVKEDSSSSDVVTVILEKAGGGTGLGFGLDGGRDSPHGDRPLTIKKLFAGGAAAQSGRILVGAELLSAGGQSMEAFTRTQAWAALKSLPAGPVALVLRNPMGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI37</accession>
    <name>A0A194RI37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI37"/>
    <dbReference type="STRING" id="76193.A0A194RI37"/>
    <dbReference type="InParanoid" id="A0A194RI37"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000073">
        <property type="entry name" value="Trypsin alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="583"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="808" mass="89371" checksum="7EBDC93EFEDF266C" modified="2016-10-05" version="1">MRYITLQRAMVRSRRDKIWRWRCQWCFISVVAVALVLYNAAANIWLLHPSCAQSGPTSRPAPTAPTAHSPPPTEPPCEPCLEAAPSAAADDDPIGRLDLRLGRWDGSRSYRLFDYATLGDVYAEVSASRRVCLATQSSIERLHELMRIAAHWSGPMSVAVFVAGDELRLLRAFATWLLRCRPEIYGRLALHAATPAERPGTQGAAPSWARDCEAKPLPPAERRADTVAWRARHPYPQNHLRNLARRNCHTPYVFLVDVDIVPSRGMAEALDAFLARAPKCPLCAYVVPTYELDKRVAEFPANKSELLRLSKNKLAIPFHRKVFIYNQYASNFSRWEASGGNESCETHVSHDVTNFELLYEPFYVATDAVPAHDERFLGYGFTRNTQFCLLTEGINRGRARINIYCMNGPARPIKYHDHRHEVEVCEGGLILVLFHFRPFYARVDVDLTVEGTHRKGNSIPVHPLLRRLKEAVEGECCKEEGDNPSTDVELQDVDLQEACPELSGQIIGGRPSSVTRHPYQVSMVMNGNSFCGGFIISPDYVLTAAHCVQKTYASSGSNSANTLYVELQDVDLQEACPELSGQIIGGRPSSVTRHPYQVSMVMNGNSFCGGFIISPDYVLTAAHCVQNTAAGAIRLRVGSTRRDSGGRIVNVANVTVHAQYGRPRFDNDIAALRLARPLVFSNAVRAIRLPQPRQPVPLVRLTVTGWGLTAPRGRRIPRTMMEARVPVVPHWLCRLSYGDALTDNMFCGGHFLIGGVSSCQGDSGGPAVFRGTAYGVVSFARGCALPLSPTVFTNLAALRDWVSQNTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIS1</accession>
    <name>A0A194RIS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kanadaptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIS1"/>
    <dbReference type="FunCoup" id="A0A194RIS1">
        <property type="interactions" value="1460"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIS1"/>
    <dbReference type="InParanoid" id="A0A194RIS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19856">
        <property type="entry name" value="DSRM_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22677">
        <property type="entry name" value="FHA_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="700" mass="79815" checksum="FF520838758D30EB" modified="2016-10-05" version="1">MEDNSKNKNENTEFKKPVLVGRIGKLPKKAKLEADKPKEPKTEEINTQSSEPIAKSSLPPAILMKELATPIPYKEPKWSGICPDGSEYGLEVLKSGMIVEKVDLTTRPFYVFGRLANCDVMMAHPSISRHHCVLQYKAFADEGEPPCGWYLFDLGSTHGTFLNRDRIKEKHYSRVRVGHQIKFGNSTRTYIMLGPDFDCEGESELTVTEIKQKALDMKLARAKMIQEAKESMEKERLEEEKKREEQGIDWGMGEDAEEEPDLADNPYASTANEELYLTDPKKTLRGYFEREGHELSYNCEERGVGQFICRVELPIDDARGRPVVAEVIHRGKKKEAVIACALEACRVLDRAGLLRQVELPIDDARGRPVVAEVIHRGKKKEAVIACALEACRVLDRAGLLRQSKHESRRRKERDWSADDYYDSDDDSFLDRTGHVERKRKMRMIKLGAAEDKNDKPLTYDDLLKQIEEIEQKIMMEEKSLVRLRSGGERQAGTNNDDDALDAYMNELAAKPQAMAVKADISKTKMNIQKLKAELAKTQRLADIARPAHAPPIIKKDDKKMTVKVGTNSVVYGKRLKLKDDEKRPKVKQETKKEETEFVEEMDSDEENEVTKIKSETSKLKTKDNNVINETKSVENIPEVEKSVIKNDDNSETMVKLENGENPVKRVFGPMRPPDDYVVPEGYFDQETDRDLPEIEEKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKB7</accession>
    <name>A0A194RKB7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_12121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKB7"/>
    <dbReference type="FunCoup" id="A0A194RKB7">
        <property type="interactions" value="1120"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKB7"/>
    <dbReference type="KEGG" id="pmac:106721557"/>
    <dbReference type="InParanoid" id="A0A194RKB7"/>
    <dbReference type="OMA" id="IYKRYWI"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="316" mass="35908" checksum="0B4E8EC6A8506F79" modified="2016-10-05" version="1">MGLCKCPKRKVTNQFCFEHRVNVCENCMVTNHPKCIIQSYLQWLQDSDYNPICEICTKSLSEGECIRLTCYHVFHWECAESRYRALPRTTAPAGYQCPSCATPVFPPPNLVSPVADVLREKLAGVNWARAGLGLPLLSDDQDMKGAASRRSQSPLEKFQYSNNIMDSHRGTPVGASDDESTNRSATSSPHSIIQIPDEPVNIYDGTSKRNDILQGGQAPRKGFKLLDNTSVIPNFDHDENKYKQKSTFAWVNRWWKNTLPSSRIRRAGGLYRRYWIMLFVLIVVIVILVLLSHRDVDDENPFGVIHEDGHRILQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKC1</accession>
    <name>A0A194RKC1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L40, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKC1"/>
    <dbReference type="FunCoup" id="A0A194RKC1">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKC1"/>
    <dbReference type="InParanoid" id="A0A194RKC1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23802" checksum="A18FD91BA212C7BA" modified="2016-10-05" version="1">MLKTLWCACHLAGNHVLSLSTPTAINRNIFTAPTLQFKITEQLCAEPLKKKKKMDPAIIKAREDRRRKKLEKQIRRLEKNARQLKPIDELEIPLNVVDQIGKRKRPDVKLSEQEVEARALLQKEWSRYKRAEYMSTVAQIDRIMGAQKRALDMLYEESEDLYNEAVMPDLKLIPYSIKGPVATPPIKNYDSPDGEYIDVSKKWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLV0</accession>
    <name>A0A194RLV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLV0"/>
    <dbReference type="InParanoid" id="A0A194RLV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="8868" checksum="78B8C4718F4764BB" modified="2016-10-05" version="1">MSGPRMERASRRAKAGSLSGLSGGLGVVGAGVAGSASVRRQRSLEWTGDRYSSSDDERPTQPPKIADRVFASLLAQATQQFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMB5</accession>
    <name>A0A194RMB5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative cytochrome P450 304a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_12479</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMB5"/>
    <dbReference type="STRING" id="76193.A0A194RMB5"/>
    <dbReference type="KEGG" id="pmac:106720780"/>
    <dbReference type="InParanoid" id="A0A194RMB5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012249683" evidence="16">
        <location>
            <begin position="16"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="510" mass="58605" checksum="D2974F7B5C446C03" modified="2016-10-05" version="1">MIGEIVLVILLGVTAVRLYKNAYKKPANFPPGPPSLPVYGAYWLVLAKAYNNLAAACIKFSNEYKSKVIGMILGTIPVVVVNDPYLLKEVLNREEFDGRMDIILGRLRSYWKKLGIFFTDGYFWHVQRRFTLRYMRDYGFGRRDESLESTVAHEVKEMIDMATNGPKYPAENDLVKGDQIYLPHFFAVPFMNGLMHVFTRACVPRQDYHILWTTARGALRFQRSSNDFGAALSFTPWLKDFLPEFSGYKGLKEGNQCILDLFTKIIKEALDTHDSSFNRHFLDVYISKMKEEMAEKKRTTYSVDQLALVCTDYMFPTASALQSVLSLLIERLLLHPEVQDKIHEEIDRVIGRDRLPTIDDRSNMPYTEACLREIMRIETLVPLGVPHRAMVDTKLDGYNIPEGSMVSLNYVTLHMNKEIWGDPENFRPERFIVNGRLQLSQDKSLPFGAGRRLCAGETYARQALFQVFAAFMQAFQVSTIDGKPYKQLAPRIQGIITTIPNFWIRVTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RME1</accession>
    <name>A0A194RME1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated protein Hem</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RME1"/>
    <dbReference type="FunCoup" id="A0A194RME1">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RME1"/>
    <dbReference type="InParanoid" id="A0A194RME1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1121" mass="129350" checksum="255A4D4DAB03D0BA" modified="2016-10-05" version="1">MSRSLNISQQKLAEKLIILNDRGIGMLTRIYNIKKACGDAKSKPAFLSDKTLESSIKHIVRRFPNIDVKGLQAISNIRNEIIKSLSLYYYTFVDLLDFKDNVCELLNIMDACQVTLDLTLNFELTKNYLDLVTTYISLMVLLSRVEDRKAVLGLFNAAHEMVHNQIDQSFPRLGQLIVDYDAPLKKLSEEFMPHQKVLLNALNSLWHVYPARNLTAEHWRSEQKLSLVSNPTLLLKPSETNTMSCEYLSLESLERWVIFGFAICHHMLQQDHANKMWVSALESGWVLALFRDEVIYIHSYIQNFFDGIKGYGKRISEVKDCYHHAVQRAGYKHRERRKFLRTALKELGLILTDQPGLLGPKALLIFIGLCYARDEVFWLLRHNDNPPQKVKGKATEDLVDRQLPELLFHMEELRALVRKYSQVMQRYYVQYLSGFDAVALNLMMQNLQVCPEDESVILSSLCNTAASLSVKQVEDNELFDFRAFRLDWFRLQAYTSVAKTPLNLVDQRELAQFIDKMVFHTKMVDNLDEIMVETSDLSLFCFYSKIFESQFHMCLEFPAQNRYIIAFPLICSHFQNCTHELCPEERHHIRERSLSVVNIFLDEMAKEAKNIITTICDEQCTMSDKLLPKHCAQTIAQLANRKKKDKNKKNPIEIVKPGAESYRKTREELTTMDKLHMALTELCFAINYCSKVNVWEYTFAPREYLHQHLETRFSKALVGMVMFNQDTSEIAKPSELLVSVRAYMNVLQTVENYVHIDITRVFNNCLLQQTQNMDSHGEKTIASLYTQWYSEILLRRVSAGSICFSMNQKAFVSLSAEGAIPFNAEEYSDINELRSLAELIGPYGMKLLSETLMWHIASQVQELKKLVVQNKEVLQMLRTNFDKPDIMREQFKRLQHVDNVLQRMTIIGVILSFRQIAQESLLDVLERRIPFLISSIKDFQQQLPSGDPRVISEMCSAAGLPCKVDPTLASALRQHKAELEDEEHLVVCLLMVFVAVSLPRLARSEGSFYRPSLEGHANNIHCMAPAINHIFGALFTICGQGDIEDRMKEFLALASSSLLRLGQETEKEAIRNRESVYLLLDLIVQESPFLTMDLLESCFPYVLIRNAYHEVYKQEQMLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMI8</accession>
    <name>A0A194RMI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMI8"/>
    <dbReference type="STRING" id="76193.A0A194RMI8"/>
    <dbReference type="KEGG" id="pmac:106721148"/>
    <dbReference type="InParanoid" id="A0A194RMI8"/>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF11">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="18042" checksum="0AD75E75B2CB51E6" modified="2016-10-05" version="1">MASRTCAKFFLTVICNKVYCASGKDNGFGNSYVWAGSLESGIQIGTHHKKPVMVIIHKSWCKACKNLKPKFASSSEIQTLSKHFVMVNLIDDEEPEGNTYSPDGSYIPRILFVSPKGQVDHDIINEDGSSQHKFFYSRPEQIAKSMKKVIQKYKLEEFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNN6</accession>
    <name>A0A194RNN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase, cytosolic 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNN6"/>
    <dbReference type="STRING" id="76193.A0A194RNN6"/>
    <dbReference type="InParanoid" id="A0A194RNN6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="532" mass="57529" checksum="FA003A957454E154" modified="2016-10-05" version="1">MKTVRCTICHLQATTSPSDIYRVLYDNLTSLIVLSGENQIAPDDSITFQPMITNRLFIDNKWVDSVSGKTFDTYNPHDGSVIASVAEGDKADIDLAVAAARRAFQRNSEWRLLDASQRGQLLFKFAELVERDADYISQLETHNNGMLLANCKLFIGQSGAYIRYLASLADKVQGSTIPLNGEVFSYTLKQPVGVCGLILPWNGPVLMFIWKVVTALAAGCTVVVKPAEQTPLTALVLASLLAEAGVPPGVVNVVNGYGETAGVALTHHPDVAKISFTGSLEVGKLIQQAAGANNLKRVTLELGGKSPLVIMNDADLNLAVPYAANSVFCHQGQVCVAASRLFVQSGIYDEFVKRAAEYAKSIKIGAPTDLTSQHGPQIDQMMLTKILGYIEKGKQQGAKLLAGGKRVGNKGFYIEPTVFADVTDDMIIAREEIFGPVQSILKFDTLEEVIDRANDTEYGLAAGIFTTNLNTALQFSKHSEAGTVWVNNYLTMGPQAPFGGFKNSGVHRENGSDCLEAYMEVKTVTIALPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNU4</accession>
    <name>A0A194RNU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_11135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNU4"/>
    <dbReference type="FunCoup" id="A0A194RNU4">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNU4"/>
    <dbReference type="InParanoid" id="A0A194RNU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="589"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ19508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="624" mass="71591" checksum="74146AA7AC8B261F" modified="2016-10-05" version="1">MKNELLSSAEQKLQEDVFEILKRTQHVTTHEYRSDVRMSLDCLVCRSAFSALFELIRAGASDDDLIRSLSNICVLLGIESYNVCSGAISLNLNIITYIIRNTPEATPRNFCGLVLQRSDNPNFCSYNDSRFEWQVELPQRMQSANVPTPVIDQSPLTVAILTDAHIDPLYEAFGVAQCDEPTCCRKGQNLRPSSDIVTDGSEVENSVIRHGDSVLLNLGDVPKIKEIRMRNSMKAQTRYVEPAGYWGDYRNCDTPRWAFDDLIERMASTHKFDVVYYIGDTIDHGIWETSYELIDEIHQYLISKMRTTFGKDVLIIPAIGNHESQPTNQFAPMSVTEPKLNTTWLYEGLTKKWDPYLTEEAKASLRVRGGFSRLVRPGLRAISINTNVAYKYNWWLVYDPLEMKRHLEWLVQELHGAELAGEKVHILSHIPPGVHDLAHVWTREYNRIVNRFSSTIAAEFNGHIHSDEFKIFYSTVEPKSPINVAWGVGGATAYTNYNLNYKIATFNPPTYAPQSIKTFIYNLTEANLTPNRRPHWFQLYDMKNSFGVKDLSAQSMDDLLQRMVTTERNLLDLYVAYVPKLSDTRWPYCNNNCKLDNVCRIVTTVLWQREKCDQLQLLYSNTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPS9</accession>
    <name>A0A194RPS9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPS9"/>
    <dbReference type="InParanoid" id="A0A194RPS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="8710" checksum="5CB2569EACBD6DEB" modified="2016-10-05" version="1">MTKRLRPHKDKFKKAHQKLKDFGRLRPKRCIWPSIKTKRQPRNSTTRALIFLYEDLIRDHEKNITLIKAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQE7</accession>
    <name>A0A194RQE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQE7"/>
    <dbReference type="InParanoid" id="A0A194RQE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="12139" checksum="E2A5BB382DFE677D" modified="2016-10-05" version="1">MAQRMLAWLLSATENKEQNKEQNREQNKEQNKEQNKEQNKEQNKEQNEQNREQNREQNKDQNKEQNKEQNREQNREQNKEQNRTKNRTENRTEQNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRH5</accession>
    <name>A0A194RRH5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRH5"/>
    <dbReference type="FunCoup" id="A0A194RRH5">
        <property type="interactions" value="949"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRH5"/>
    <dbReference type="InParanoid" id="A0A194RRH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="9">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="10">
        <location>
            <begin position="163"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="681" mass="78601" checksum="C43DDF948CE48C38" modified="2016-10-05" version="1">MRQKHSPDNPKVMDIKVYNTLLHGYASQGKLDNAKALLSFMEEDGVSFNAQTFAAIFECIEKSDIKQKSTVLEFYNQKMQEKGIMLNDLLDKTKFVYDQREVVLNAIRRLQPDFVPSYTPPVLDYDCPLLEKLKLSDTTNRKGLLTSPAEGLLSLEDMKKKGQIQLDMEINGEIEVQNIAAQDVETDSIKLYRTKLRETEQEWRTVIKEAFIRNLSTLKSQSNASHSAITLYPYLKVLEVDQFVELMMGEIYKLVDGSESYSPTLKLLQRSLGTQVYHKYQIEQYRRNGVLQKIEQIYEKYCEWYLHRQSVDGSEQPYNGRQVWQLLEHQNREGASLDLDETPWPMEMRQNIGKFLYNIIINDVKIDVNIFKAKDKQKKLPAVYKVHRPWGWLVRLELKPHPVVARLWAAAARPALRMRASLAPTLAPPAPWRHHTAGAYLVTDTPLIRLPFYVSNQMKRIEESPQHALYPVLDSLNQLGEVPWVINQPILDLQIKVFRWKQEAGYSISSVFTGRVPVFAAANYKRRLANQFARAPTLHSLWCDALYKLSLSNHYRDSMFWLPHNMDFRGRVYAVGPHVSALGADAARALLRLAQRRPLGPRGLRWLMLHAVNLTGTMKNNTLDERYEYAQSIMDKILDSADKPLDGEGWWQRSEEPWQTLACCMEIANAVRSPNPEGNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRH8</accession>
    <name>A0A194RRH8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRH8"/>
    <dbReference type="FunCoup" id="A0A194RRH8">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRH8"/>
    <dbReference type="KEGG" id="pmac:106711090"/>
    <dbReference type="InParanoid" id="A0A194RRH8"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23206" checksum="9D24242FA9F9DDE1" modified="2016-10-05" version="1">MSNINLQCLLGIQCNDFVMIAADQTNSHSIMVMKDDEEKIYKISDKLVMGVVGDSGDTTQFAEYIAKNIQLYKMRNGYELGPTAAANFTRRNLAEYLRSSSPYFVNILMGGYDKENGPELYFMDYLASSIKVPFAAHGFGGYLSLSVMDRYYKKDLTEKEAYEILQKCVQEVHKRLFVSLPNFQVTVVKREGIEVLPVINSSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB74</accession>
    <name>A0A0N0PB74_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein light chain roadblock-type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461113">
        <property type="protein sequence ID" value="KPJ08919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB74"/>
    <dbReference type="STRING" id="76193.A0A0N0PB74"/>
    <dbReference type="InParanoid" id="A0A0N0PB74"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="8861" checksum="A517C72553F22017" modified="2015-12-09" version="1">MGVIIVNHEGIPIKSSLDNATSVLYSGLIGQLTEKAKNVVREMDSTNELTFLRVRSRRHEILIAPDREFILIVIQNTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB82</accession>
    <name>A0A0N0PB82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461002">
        <property type="protein sequence ID" value="KPJ10045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB82"/>
    <dbReference type="FunCoup" id="A0A0N0PB82">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB82"/>
    <dbReference type="InParanoid" id="A0A0N0PB82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124763" checksum="40732BF734BB49F7" modified="2015-12-09" version="1">MAQPQPLPRRKRFIPKYDVEGVFHVVLGEETQFQIEMVVGTHINAQYPWKLVSKDKIMESINLGGELSEFYPLKKELESYKDDEVLMGYMADESKDVDEFYVCCTPEARDHCKQQSEKFIRRQEKKLEKAIQKKPKPWKGFGSEAEIIELVPVNTRPLFEIEVKSQYLMKYQPSRFKVRDTNSVRDGYTELTPYRQKYNNVFCRRVDCGSQAASPKVDREAQTYLRYPQNVWTQTMIDTIGRGNDTDGGGDTIRKDDTEESSDEEADAATKPTDEAELVTYNAAMKRMRRASYIKSLDKFMSAREQEMESILELNTVMDMYCNDYPGLVTEKTVDVYNSMSFEEYVCFTDVRAKDKFISSAVFHPMWTGIVAISYSDGNPTIMKTLSSRSDPIQRAIYGLNPVMIWSHIDSLRPKLYLQSPREVKVLSFCPFNENILVGGCINGQIVVWDLTNKLLNVETIPVLSETREKYRIAMNAHMDWMKNVQDNAIVEATALSNILTSHYAPITAINWLSPNFEVTPTGKVVMAPEDRKSLMLFTGSEDGNILIWNLSVDNVTTLETKKIKKSKRVPKRPSGLLVDISPYKVLDRNLQPCFKIILGKVGQPQAMPIQRFGIKPPLIKYIYVPKYLGDGRKYFEPEIIPQNETDISKIIYCGSQHGELARVLWEGHEFNTGEVVNSEYCEITYSCFIHDGVITSVQINPMLSNLTLTVGGKIFAIWSNDLVGRPLFWKKRPSRLTDGVWSLYKPSVIFIGTSDGDLETWDILLRSDKPITVQTLSGTMLTGVSLHSLRLTKNIIGVSDLNGSFRTFLDPPIFMLESQSYKTRMETMIKREVKVMQSFVAWQKELINSNPQILLEIKRKEGALLAEKEEEKRRLKEEEEKRMEEEAEAQRRQKQKVIGPEERWQMIIQSLIEKTIAIKKRINRAELIEQEKPLRELEAQRLEKERRMLEIMKNQKNIFNDTVAILFPEAIKKEVKQKRTLLSLDKTCLQKDYIEEYQYLKAASLKLVHENPYKVPFSWEATISEGKERRQALNPFDDYIKMHKARIDEEDNRTSSLSNKEMVYMEAEGELAEVSEEIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBD3</accession>
    <name>A0A0N0PBD3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein light chain roadblock-type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461053">
        <property type="protein sequence ID" value="KPJ09946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBD3"/>
    <dbReference type="STRING" id="76193.A0A0N0PBD3"/>
    <dbReference type="InParanoid" id="A0A0N0PBD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="13571" checksum="E5E84D00CA454D5D" modified="2015-12-09" version="1">MKVLSNLLKDSRDEWLINTTISLNAVNPIVDRIMEDESVEGVVMTNKDGSPILTNINVMGATNYGTAMRRLGFMAQAGVKEIDPFDEVLILRLKTQKLEVMAAHHSEFNVIVLQHSRVSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBU5</accession>
    <name>A0A0N0PBU5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBU5"/>
    <dbReference type="FunCoup" id="A0A0N0PBU5">
        <property type="interactions" value="1207"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBU5"/>
    <dbReference type="KEGG" id="pmac:106715119"/>
    <dbReference type="InParanoid" id="A0A0N0PBU5"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000006">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="355" mass="38775" checksum="D48AD22709021019" modified="2015-12-09" version="1">MSDDDVIVMEVDEAEPKVEKPIAGPSKPLGLLPWIEKYRPQTFDDIVGNEDTVSRLAVFARTGNAPNIIIAGPPGVGKTTTILCLARALLGAAFRDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPPGRHKIVILDEADSMTEGAQQALRRTMELYANTTRFALAANNSERIIEPIQSRCAVLRYSRLTDAQILAKVIEVCRKEDLSYTEEGVNAVVFTAQGDLRAALNNLQATAQSGRHVSPENVYRVCDEPHPMLVRTMLEACTRQDIHQAYKVIAKLIKQGYAAEDIVSNMFRVCKTLAVGEELRLGLVREVGLTHMRVADGLGSSLQLAALLARMCRVSAATPPATTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCG4</accession>
    <name>A0A0N0PCG4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GLE1 RNA export mediator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_03017</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCG4"/>
    <dbReference type="FunCoup" id="A0A0N0PCG4">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCG4"/>
    <dbReference type="KEGG" id="pmac:106712052"/>
    <dbReference type="InParanoid" id="A0A0N0PCG4"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000001">
        <property type="entry name" value="Nucleoporin GLE1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="650" mass="74649" checksum="E9532AEF30945339" modified="2015-12-09" version="1">MSDISVLSDLENSYNIMNNLSKENIKKHDISISDQLADFEKLRISALTKAAEISPLVKEVTIGPKSPLKNMTTKENKPVNKDDNDLNLLEDKIGEDLRYTLMLKEYESKLLESSEELFKNLIEKMIAKHTESMRTFWKKQSEESERKALEMRAKRLQMVKQLQENDNLSVLDKAKLDEKNCQIINKSTIENMNRILEEQNKAASRFAGITDSRTKVCICYNDICNILNSEPHAKTIYDKYVTSIDAIIGNVNAIMDLCKSGIITDKEVKQAEILSVNIENIQRKILEDLNEIKQKEEEAKKKEIEEQRIQKENEIKKAINENVEKTDTTIEQPKKTIPMFYSSKNYAYFVELRDFLNAYESTYKDLLENTNLKKFRFDCQKAVNTPVNALSSVSGAHIRDKFDKLYKLLRGERVQVLDTYVQATQHPQGLNYCTALLAKKIVRQGDLLVSSNPEAAFPLAAVAVALWSQFPEFGKLLEANFHRQCPYLVPMLLPQKQGQTDKEFYISRGYSYNEDGAVEKQDKFLKRMSGIFQLCCAIWIAKMPKFVNTPNPHGLSHGWKWLASFINLKPEPDICATLLHDFFSVCGSEFYRNYKKQFVKIIKLISSDYLKILENIDEGGPKTRLEVYLQNVLKTGQVPPPSGLLPPNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCI3</accession>
    <name>A0A0N0PCI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460569">
        <property type="protein sequence ID" value="KPJ13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCI3"/>
    <dbReference type="STRING" id="76193.A0A0N0PCI3"/>
    <dbReference type="InParanoid" id="A0A0N0PCI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF86">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="291" mass="32272" checksum="894DFB60FD1E150C" modified="2015-12-09" version="1">MRSMCVPVVRRCVVRALFATWMPETPQYLLSKNRRRDAEKVLRWLRGPDADLTAELADMQKDVDDAARQRAGMLSMLTNKASRMALVCGLGLMFFQQFSGINAVIFYTNNIFQSAGSNIPPAIATIIVGVVQTIATYVSSLLVEKAGRRLLLLQSCIIMGLCLIILGTYFKLQASGASVASFGWLPLVCLVLFIISFSLGFGPIPWMMMAELFSVEFRGSASGITVVVNWCLVFIVTLCFPLMKDAIGIYSCFWFFAAFMIICIFFVFFLIPETKGKTVSQIQAILGGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCR5</accession>
    <name>A0A0N0PCR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium voltage-gated channel protein Shal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCR5"/>
    <dbReference type="STRING" id="76193.A0A0N0PCR5"/>
    <dbReference type="InParanoid" id="A0A0N0PCR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent Kv4 C-terminal" evidence="10">
        <location>
            <begin position="158"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="298" mass="31920" checksum="BC98C968F75C8ADD" modified="2015-12-09" version="1">MVPGTIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHHFVTKILLCHKINTRERNEGKYTYNSSYGDMVPGTIAGKIVGGVCSLSGVLVIALPVPVINHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARLAAQESGVELDDAGRDEDIFELQHHHLLRCLERTTDREFVEMENPYNGAVKRPGSPSPLASPAHSGRAPALLACCVRCGCCPQKYQVLLLDPGRKGRARGNRRYTATSRPSDTSMSAAPSEDPLPQACGKYIPAGSTVQGNQTGVAMDGTYLVEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCZ2</accession>
    <name>A0A0N0PCZ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCZ2"/>
    <dbReference type="InParanoid" id="A0A0N0PCZ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="40" mass="4554" checksum="F35762B6C233B351" modified="2015-12-09" version="1">MSAQVENYKCRRRLVSSELRASPRLCVGVMLGMLLDESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD12</accession>
    <name>A0A0N0PD12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hairy/enhancer-of-split related with YRPW motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HEY family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460401">
        <property type="protein sequence ID" value="KPJ14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD12"/>
    <dbReference type="STRING" id="76193.A0A0N0PD12"/>
    <dbReference type="KEGG" id="pmac:106710883"/>
    <dbReference type="InParanoid" id="A0A0N0PD12"/>
    <dbReference type="OMA" id="QWGYGWG"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="34035" checksum="711FC5B2C39D0F9D" modified="2015-12-09" version="1">MEYHHRPMEQQQQQQGAGGGAGPPAQPQWGYGWAPPAPAPRSKRPHSDSEDDAFSEESSKDAQSPGGESCQLMTRKRRRGVIEKKRRDRINTSLTELKRLVPAACEKQGSAKLEKAEILQLTVDHLKMLHAKGVDTFAYDPQRYAMDYHSIGFRECAAEVARYLVSCEGLDIQDPLRLRLMSHLQCFAAQRELAAKSANWGYPQYPAAPAPHSHHGYGDVAGQRHDPATSAGATSLAATTSIAAPLSAPPAYAHYAHAPPGPPPPAPPAPPGPHPAPPAPHYPAPYPHHPPHHQYSQNTSKPYRPWGAELAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD20</accession>
    <name>A0A0N0PD20_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD20"/>
    <dbReference type="STRING" id="76193.A0A0N0PD20"/>
    <dbReference type="InParanoid" id="A0A0N0PD20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="844" mass="95024" checksum="830CC051E1C6F6E6" modified="2015-12-09" version="1">MVIKVGINGFGRIGRIMFRTCILNPDVEVAAVNDPAVDVEYICYLIKFDSIHGKFEGDVAPCKGDIQINGNLVKIFRAKQPCDVPWNTAGVQYVIESSGMFTNLEKAAGHLSVEGVKRVVVTAPSSDVPMIILGVNDDKLRADQRVISCASSTLYCLAPIMKVLENNYGVSEGFVTSIHAMTPSLKPLDGLCLRGKHWRDFRSIHQNVIPAMTGACKALGKILPELKDKMIGLAFRVPIVNVSVLDLTIRLSKKTTLENIVKNVENASETYLQEVLNISKEEAVSSDFIRDSHSCILDVNSSLQLRPDFYKLICWYENEFSYACRVMDLIIFCERRFEQKQTLEGKIVDGVTESPKLTDTAAGLKRFKPAAGTCRQQIPNTIKTFSKSVYSSLQDLQPWTADVSVVHQGTFTDRQPKKVNELLQVPTVDNMVKNVSVSTSIQNIEPTSSASNNIEAKPSVNKNVHKSTKHERNDFFGQNHLESVRKELNKMMNVTQGLLEKSNRLCDPFKFKFEDQELKKNKADRCIAFVESNESIQCTGCLTKSQGTFIINKQLETACSGRGDTKNDNARLMSVEHSALTEDASKLHDGDDISKFHVKTLYDTNFEEISDSRHAGELVQKRAITKLQKTSTSFLRENPYVYSFNKKHEFRNDQLKKQLQKSSPVSINMEGLNLASNEAHCSENISRYIIVQETENTKNDRKFLGQRLVGKQNILVQKQVICENVALRSNDNNNAFVKKDSNKTKQDIFDKLDSTSATNSENSFHVKEKQSQVICINDLTNSLEDLSRLEKICKIIEISDDLSDELFSKLKPTEATCMKNKKWSFKDLCAKIKLDDFCDKVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD76</accession>
    <name>A0A0N0PD76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD76"/>
    <dbReference type="STRING" id="76193.A0A0N0PD76"/>
    <dbReference type="InParanoid" id="A0A0N0PD76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="32624" checksum="62B2460194875C8D" modified="2015-12-09" version="1">MGRAQSTTCASRTCHLSHRARRRSGSSIVVLGGEEEKRPPPDDDLEMLTMLSLTSDTGPHREMPVDVPENFIARSKTPPRYPPPRPPQVLARACDHQPLLSSKRSDARDSDVSDTSDTSHTSPPASDASGSFKNTTIELLSLPQSDSSISYSSKQSKASSETTKCDLISESESVASNTTHNLSDHKIQLLISNGQDSLIDCREGVTYSARTDSVLIREAVYASYKLPPGFDTTPVLLGREVAVDVPENFVQIVKTTPKYPGTVDRKSVLQVNGTIACLILIHGIRCGLGYLDGYTRVNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDI7</accession>
    <name>A0A0N0PDI7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_05656</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDI7"/>
    <dbReference type="InParanoid" id="A0A0N0PDI7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="217"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1089"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1155"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153598" checksum="449AB555FE62B3D5" modified="2015-12-09" version="1">MTAFVPDNPRNGWTNVDGTLMGSEVNTDVTLLEYLRRRLRLPGTKYKCLEAGCGACIVTAVRGQDTPPTAVNSCMVLVTSCQGWDITTVEGTGGRLAGYSKVQTTLAEHNGTQCGYCTPGWVMAMHSLLQSEKNLTMLEIEQSFGSNICRCTGYRTILEAFKTFAVDAPASKRIMDIEDLHICKRKGDGCKKTNCDDYDWCMVLKEEVNKASTVHIKLEDGRDWYRVYDLNEVFNILVSKGQDSYMLVAGNTAKGAYPIAEYPQVLIDTTGISELKGFVVDQNLVLGAGTTLSEALDIFKSLSSEKQNFSYLGKLYDHIQMVAHIPVRNIGTIAGNLMTKHKHRDFASDLYLLFETIGAQLTILSSAEKKIVTMQEFLNVNMTGKIILNILCPPLSQDYKLVTYKIMPRSQSVHAITNAGFLYKLDENSKVLESRLVFGGLSPTFTRASKTENYLMGKYLFANETLQGAIKVLDDELVITRELPKLSVEYRRRLAIGLFYKGLLHLCPSNVVGARYRSGAVAIHDTRPVSQGSQEIQTDPTLWPLTKPIPKIEALRQCSGETIYTDDLPPIKNEVFISFVLSTVPLGHIDVIDPSIALKEPGVVAFYSAKDIPGLNSFSPVDDTFFLTNEEILCSGDVKYYNQPVGVIVAETQHIADRAAKLVTVSYSNVKKPVIDVTEAIKDTNRLSLYTSVTATNKGSDVSKVINGSMTIYQQYPFCMESLCSVSIPSEDGLEVHAATQLSMGVQVAISRALNIPLNNNLFNRDEKNDEIEPCHAIKVGIHYVREPLALRAPVTALMETGRRISIGTYILYSPLVNIVPLCSPNLSLPVGALSAERAPYALRVRKRIHYAELLQERGAQEVREHSGYPAEQKQFSRIDVYVRQVGGAYGYKLTRNNQGIVAASLATLRLGRPCRFVQNLTTNLRAVGKRCPCTTNYEVGVNAKGVVQYLNSNMYTDNGYTVNEPLIMLAAPVFNNCYNKATWNYNLYNVVTDTASNTWCRSPGSLEAIANAELIMERISYEMNLDPVNVRLANLDLASSAVQEMWDNLKIKSQYDERRADVQKFNSENRWLKRGLRVAFMRWSSLNTTFTSATVSVFSDDGTVAITHGGIEIGQGINTKLAQICAYFLQIPLSKILVKGQNTIISPNAAPTSGSVASLNVALCVQRGCEDLLRRLEPIKQQMGGNPTWEELVKKAYKSNIDLQGRGILNLGDENSSQVYGVIVTEVEIDIITGQSEIKRVDLLEDVGQSVSPEIDVGQIEGAFIMGLGYWTCEKMEYEPRTGEVLSDRTWNYWVPQAKDIAQDFRIYFRENSYSTNTYLGAKATGEPGTSLAVAIPLAMREAISAARLESGIPTNQWFQINGPYTTEQICLAAATKFEDFKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDY0</accession>
    <name>A0A0N0PDY0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_01687</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="KQ459998">
        <property type="protein sequence ID" value="KPJ18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDY0"/>
    <dbReference type="STRING" id="76193.A0A0N0PDY0"/>
    <dbReference type="InParanoid" id="A0A0N0PDY0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="11">
        <location>
            <begin position="148"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="300"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="840"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1170" mass="135418" checksum="FE23A06A83EC6008" modified="2015-12-09" version="1">MIDRKTSEKLQLLPTLNLDEAYKMAWQAEEQAKETKIMWNQEEILNVNKLGKRLVADQSYQSRELCKGGTMGRSIPLREESKNRQCWWCGRPEIHGKEKCPASKERCFKCMRQGHFARCCRERKINFMDNEEFKLEVNLECEDFKTKVKFLVDTGADVVAIPKKLLDNGCKIFTCSETIRGPDGSPLDVEGFIWIQLSYKDRIYKGKAFIINNLQIPILGKPAISKMNILRLCNLAEVCNSDIDIEKEFPNIFNNLGVFQDTFTIKLISNPVPYVQSSPRVVPLPLLDKVKEELSRLVSLGVIVPVEEPTMFVSPIVVVPKGENGVRICGDYTQVNKNIIRPIFPIHKVENTLGRLKGAKLFSKIDATSGFFQIKLCEESRKLTTILTPFGRYMYNRLPMGLNCAPEYFSMKFSNLFHDLEGVVIHVDDILLYSKDRESHIKLLREVLKRLSKEGLTINKEKCKFLVEEVTYLGHVINSKGISVDPKRIESIVEFRVPSNKKELMQFLGLVNYVGRFIPDKSTLLEPLYGLLKQGNAFVWDRCQQQSFEKVKYLISRAPTLCHFDPKSKLIISADSSSYGLGAVLLQEDDTGKRDVVSYASRTLNQTEKNYAQIEKECLALAWAVNRFRDFIIGIEILLETDHKPLLQILHTKPIDDLTPRLLRFRLQLMRYKYQVIYVPGKKLVVADALSRAPLKDTEVEAELNIKYISSIGWVDSKLKIIKEEQSKCKICSQLKEYTVGGWPDQNKIAEELLHYYPYRYNFSVQEEFLLFNTRLVIPTSLQKSILGDIHAGHLGITKCRERAKQSVWWLGLSSQIKVVVENCPQCIQERSNKREPLIVEEVPNRAWQKVGMDLFKNKNMWYLVIIDYFSRYFELFELKDLTENSIIKHCKETFSRFGVPEIVRTDNGTQFKGKFKQFSEVYNFNHVTSSPYFAQSNGCAEAGVKIAKNLLNKNADMYLALLVYRNTPNETGFSPSELMFNRKMREILPMYPGNLNNKVEIDNNLFRDQRNCNKGKTADNYNKRHRVIKLNDLNVGDNVWVIDLRKYGLIVRKAKEPRSYFVAIDGVQYRRNRWHLIPAPFKNNKENNTYGRDIFEHFQHKDQKCNNNCVPGVNEDVVERTELSDNNDTNSETAEFETPEIQSQSFKLPDRKRTKPKWLEDYVCDYIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE17</accession>
    <name>A0A0N0PE17_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cardioactive peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460127">
        <property type="protein sequence ID" value="KPJ17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE17"/>
    <dbReference type="FunCoup" id="A0A0N0PE17">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PE17"/>
    <dbReference type="InParanoid" id="A0A0N0PE17"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024276">
        <property type="entry name" value="CCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11105">
        <property type="entry name" value="CCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="16133" checksum="B73CADD227E9A33E" modified="2015-12-09" version="1">MTLSDKVVPACLHVDMSERDERALASGWGATQNRGSSADILQKIPRNFDSRLSDDVIMTPKKRPFCNAFTGCGRKRSQYAPGMPQDIGRQRQYVDDETLGSLVDSENAIDELSRQILSEAKLWEAIQEASAEVLRRKQKEYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE47</accession>
    <name>A0A0N0PE47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE47"/>
    <dbReference type="InParanoid" id="A0A0N0PE47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="10">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="10">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="9">
        <location>
            <begin position="242"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="636" mass="73642" checksum="FE6C180C1D49F1E2" modified="2015-12-09" version="1">MDEWMDNDSAQPKSRATASSKFYIAIARTLEAVDGATPDSNETTVPPKNNPGRTFRDGVRKIDLILVVKDEENLIADPMKNKFLTNIVKTGLEIEFENGVLPIHKKLVFFKVHCPNDVLNNLGNAFGVKCVQIARAEHTMSNKERDWINLIRKEYTQPLQYSSLERSLVVYMTLLNLPFGDRQNYIGLERLMKRNIVVEAYALHDGPYFITQDATSINARQILFYNWVGITNIFTKQPLNVVHEYFGPKVALYFAYYGLYNLFLAIASLAALITLFLAIFFNENYMDLRAPICEGETVDICFQCYDKSQDVVRTVVKTTPYITLTSMEDGGGQKGIFFTAYWFGREKYFNWIWETRNKNFNRNQIRPEFDLNLDTARKSNKTGIVIGIHRGSKIKTLLWYIPVAIFEFQFWRGYKMDDKFLLDETCVLTSCINELAIAFTIVLLLRFVILRKLSRYSRRDAELFTLHYRRPLFLKNKSFSIWSEILKLMVVSLVCSTDTIEAYLREQRKPTGNTLNQYLNLYFHNISKGLIILAVCEQLRGGAAAQRVRCGRATNPPGLRSKYVADAQRFRRVLSAGLRRIVQSLTKWIPTRKHCCWLCYFEDTGDANESIDDFGRIQYQLFNWMRATTLCCFTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFB6</accession>
    <name>A0A0N0PFB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01017861">
        <property type="protein sequence ID" value="KPJ21054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFB6"/>
    <dbReference type="STRING" id="76193.A0A0N0PFB6"/>
    <dbReference type="InParanoid" id="A0A0N0PFB6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="24403" checksum="0537806DA8E0E82F" modified="2015-12-09" version="1">MSMYRFVKEGSSKRLFVQGTLESEDNKPLKSSLRKPSPSPVGSPITTSLNLASVPRSLREGLTRNETVYDGNYPGMERSSSYRSGSFREESYNGRIVHDGNQTHFEYDAGESALAVPLSAGGRGISELQAIHTNKRMSTEVLGSSLESTKISKKDDSGQRRITTRIVRKVTTLTRGEEKASTEDIARGGREVHRSSEHYRHMEMERHPRKVKVPFITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA53</accession>
    <name>A0A0N1IA53_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA53"/>
    <dbReference type="InParanoid" id="A0A0N1IA53"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="938" mass="108417" checksum="A346B2A355C97986" modified="2015-12-09" version="1">MEDDSLQKDENCENSVNIKDDKSSENFQKFIYELFEKNGVLSDLRAYLRGHIVNVLKNVNTDDTPMCQKHFAQRLELTYQALNILVAEYLLRLDFTYSLSVFVSEIPLANMVFDLANSLLQTKIDDDYKELRFKDSDVWCMFSQLRTVYETEVEMVREEEERKIKRSLANHALLLQKKYDEMFSQLRTVYETEVEMVREEEERKIKRSLANHALLLQKKYDEMEETFKAREAELESNVQEKKKFLWGLARALRDQHSNMSVAMNTVQMETERLNNKSNLEEISERSRSSLLESSAERGRHLESMLRYENERLKAFSEQQREHIDELAREQVRLRAELVAARLGSPRPRTAPPLIPPTQGVNPSGVRGACGLRRGAGEELSVFAQPRPLLPTDPIPFLGTLPHTRADRHADRHADTRRYMINQWRGLRRLPPTTPQPGSSTQHNTEETTNERQSESQEAGPCANFLTEDREDSNQQPPEIVIEGKKRETSPKSVLREAKQKLRNKDIKKQEAKTSREKSPNSMLREAKLRLRKLEIEAEAVEKSYLDFKRKRNELRREDDKFTEESVPSVGESAHNLFEQSSIIQKNKEENRNDIHNIKITKDFLHNDFDKYLKEYQSKEIMKPHFENKTTTANKIKPIPIAYKMTDNIETIQNVDYINTPLNEFRKLYHNEKPRRIKKDNKTKYVLNENEIERNIKVEEKTESVIKIVNEPNKEIIKIDLEKPDTIIEINNSNSDQKNGLSNDNIPCKDEIDDILNIENNKEGIEDKSLLKVELDNLIETASVKIDEGDLMVIIETSIASELTISQDNDRITPVSELITPKDIELSDNSKNINSKSSISIKSPSTKLPISKETPEKAAHLTRKDVLNAIFDIEAKELSNADIFMDDSKNGLDSIEADSDVKDNGDEFLADVDNYNSRSDLGNSPISHAKTSDDDIFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICX2</accession>
    <name>A0A0N1ICX2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459736">
        <property type="protein sequence ID" value="KPJ20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICX2"/>
    <dbReference type="STRING" id="76193.A0A0N1ICX2"/>
    <dbReference type="InParanoid" id="A0A0N1ICX2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="31932" checksum="00B355CE61387884" modified="2015-12-09" version="1">MGEIKEKGEQATKSKREIIIPRRQASVIVPERVPVYITPDKTTCIECGCFPKDTYVKNKKLLPCLKSPLTLYELSAKVVDNLPLPDAFTWSVEDVADWISDIGLPQYRTITSKVRQLYSTEFIKFARSIGLPPRKPLTHCTWFKSRTGPSWGIRNNWTRYQKPDFPKVKFGRVRIPKHVTYIPHYIPKGEETNERLVTRKFRLLTGLSESQHKIWVEDTTLKEKKRLPKKKTKKVQIKIYQVSDSLMPKKINLAGLTGRNLILARRKLPKTKFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IER2</accession>
    <name>A0A0N1IER2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IER2"/>
    <dbReference type="InParanoid" id="A0A0N1IER2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873959" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8327" checksum="E4B76F6C3EBFD934" modified="2015-12-09" version="1">MYLKRVLVPLFCLGLEVLTPVVADQVEIREVAADKGTNVTIPCGDLHENTSNVQWVHRGNRTHHTVLVSLFPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF38</accession>
    <name>A0A0N1IF38_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF38"/>
    <dbReference type="FunCoup" id="A0A0N1IF38">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IF38"/>
    <dbReference type="KEGG" id="pmac:106718328"/>
    <dbReference type="InParanoid" id="A0A0N1IF38"/>
    <dbReference type="OMA" id="NHPFFAI"/>
    <dbReference type="OrthoDB" id="5786980at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="14229" checksum="73B519F02E853766" modified="2015-12-09" version="1">MSLEQTACDDLKAFERRLTEVIACLQPATMRWRILLAVVSICTAIAAWHWLTDPLTPVVSLTQSLWNHPFFAFTSTFLVLLFMLGVHRKVIAPSIITARTRSVLNDFNMSCDETGKLILKPRPANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFD7</accession>
    <name>A0A0N1IFD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anosmin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460324">
        <property type="protein sequence ID" value="KPJ15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFD7"/>
    <dbReference type="STRING" id="76193.A0A0N1IFD7"/>
    <dbReference type="InParanoid" id="A0A0N1IFD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="100"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="213"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="451" mass="52032" checksum="5E4A2820CAF47AE5" modified="2015-12-09" version="1">MILSKVRRYSRLQTEPLSKTRCDLVCYDARKEDKVQCRSTCRSQERKPGTCPSTDHPRWVAACIEACNSDAQCDGTQRCCRHGCSSACSEPVDLLTIAGLPALPTLDEIKERRRSVIIQWSDGVGDAARTVPGRVLYLLEEQHHLGPKYEEAGLGEWNLLMRTNKTKVSLRNHLKPGRWYRFRVAAVSASGTRGFSKPSAPFTPRKGPRPPPAPKKLKVQRINSENGNLTIKLEWKEPRSDLPIMRYKVFWSRRVRGLGRELDSVLVNHQSVPKEQSYVIIKDLQPNSMYFLQVQSISQYGLGKLRSEKAAIFYNTTNKNDERPPEPLRKNEKDRKIRNLKLNKIIWVDHKLKAKISWESIFKNNDKSKRFFVHWKTIKCQNPQKQFKDLLAITEETSFDIYELDYNCSYLVSINKARNAKTDDSSIVITVPDCEYFKRKVNSTVIRCNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFF5</accession>
    <name>A0A0N1IFF5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFF5"/>
    <dbReference type="InParanoid" id="A0A0N1IFF5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1253" mass="144107" checksum="B4FE3D9A977A7E9D" modified="2015-12-09" version="1">MNENLINENIALSNYSFNKNASNNLPVKINFSENTSISSFSNKLGKSNNSHDQKSPYLNCTKVRIISKTTEKKIFQKKPNDITSSFSQACKIYKTSSDEFKSSKGKFKKDKSSRLAVSKELSNGQQTVSDMNESEYHSRVDTNRRCKRKRRPAKKFGGPNLEEKKFEFYNGDLICTPAIKLDRKQFNQDKRINDKTQKINRTRKRGEVVRPGDLWTILRSINKFSYITSPRLSEDSIETIKRKGNYTKNQKETGKSQSICSKPSSFDRVTIVSKKGDSNFKELTKLPVTDVRSSRISKKNSLKNSYNKQKANKKNIQSVDISGTDNKTETFLNCQPSDLFKNQYSGQRPNEDQDSYIELIDNANDNSEDETLPEEKIKYIQNETSMEDNIYRESNVFLSSISSKTGLKNFSDVKINDNSKNPLENKGNCFMNENRCFSKQLLNNQRNYGIPKLTQTEIKRRLVNLKYPIVILGKDELSSTFSIVDYDPPHFDGLNQQVWPYMKEWIVDSNRNKVDSRRKVLENQIKNSLAPKHQNVPARKDCRNEMSNRKSVHNFVGNRMHSPVSKKKESKTNFQLKEDMKTNMPVPQKKKVLNQFKDKMIDFIKPQRNLVNKNVVNNHSSILRSVKHNTESKIHLESFRGVDYKELCENTSHFNKPQPNKYSWSKVKWASDFIDNIIKKIKKGMYYTQHDIDSENINSGTEVIISVPKVETIPEDENINQDVTNDTDSTTIPGFDDNRNVMPLQVDVKMITSTLVSVHYSLTNVVLHFDICIPSVSESSLNPTLPSFSPVIKPENQSMLYKCQDRIPNGMLPAKLCSILPKFISQIMKDKAFTELPNSPFNIETNANQIIPRIIFYPIMQFSLELQNLITGKFSIKEISNIDEKITPIPPNLDWCQKNTLIKKIETKRLLNFSPTLRKYMKFNSEIDIKNNQRLLTKPLINTCTAMVPYSSPFTTISQALGLNYVEKLISGINNFMIGVSRWNKKCFPSHNCRIVISDDLRRTLDSMPKFSMTLSIRELPYERIKNVDSTIKRRIPKYDKGSHEIAKKCVKKTFIKLHKKCKSLTNMSKESCTSLNKITNLDEFFHALGCYKPLSKVLMGHSDVAIMSSIIEMRSWIKEITQAQALLILLLSNKKETRNLKRFRPMILQGIAVNRITTAAELDMEIEVIEKENLCISQNEGISFLSQSNDNSLLDELCWIAKTTASDYQKPFDDSSEKLLKSLLGKRKKLNPSYLRVMARYVGLGLLKHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHL4</accession>
    <name>A0A0N1IHL4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHL4"/>
    <dbReference type="FunCoup" id="A0A0N1IHL4">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IHL4"/>
    <dbReference type="InParanoid" id="A0A0N1IHL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="143"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="333"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="545" mass="60244" checksum="24F074BB7B8F877F" modified="2015-12-09" version="1">MIILSCHRSGNWNNSRGGSGGSKFGNNGSKFGGGGGGSRFGNSGGYGGGKKEFSGGQNMRRPNWDTMSLQPFNKNFYNPPPEVLKRSSYEVEEYRNKHEITVNGSDIPNPIQHFEEGNFPDYVMQNISNMGYKEPTPIQAQGWPIAMSGHNLVGIAQTGSGKTLAYILPAIVHINNQPPIRRGDGPIALVLAPTRELAQQIQQVACDFGNASYVRNTCVFGGAPKREQARDLERGVEIVIATPGRLIDFLEKGTTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQTLMWSATWPKEVKKLAEDYLGDYLQINIGSLQLSANHNILQIVDVCQEHEKENKLNVLLQEIGQNQEPGAKTIIFVETKRKVENITRNIRRFGWPAVCMHGDKTQQERDDVLYQFKQGRASILVATDVAARGLDVDGIKYVINFDYPNSSEDYIHRIGRTGRSKSKGTSYAFFTPSNSRQAKDLVNVLQEANQTISPQLQTMADRCGGGGGGWNRSRYGGGRGGGGGGSFRRGTNFGRSNGQGGGGHKRFNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHQ4</accession>
    <name>A0A0N1IHQ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHQ4"/>
    <dbReference type="STRING" id="76193.A0A0N1IHQ4"/>
    <dbReference type="InParanoid" id="A0A0N1IHQ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="81"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="325" mass="37358" checksum="BA25EADE282240F6" modified="2015-12-09" version="1">MNIVIFTEDKDFPLIVEPEKEFTYPEHLKVYTYEMNSDWSMFPEPKRSQTGVFNYYPMDCSSVVAVLALCLSPGDRLLDLCSAPGGKALVALQTLLPDVVVCNDVSISRSNRTERIFRDYLIDFENNKWRERVLLSRVDGRIFTDDQGFDKVLVDVPCTTDRHSVNEDENNIFRPDRVKERLRIPELQTQLLVSVVAVLALCLSPGDRLLDLCSAPGGKALVALQTLLPDVVVCNDVSISRSNRTERIFRDYLIDFENNKWRERVLLSRVDGRIFTDDQGFDKVLVDVPCTTDRHSVNEDENNIFRPDRVKERLRIPELQTQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIA2</accession>
    <name>A0A0N1IIA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIA2"/>
    <dbReference type="STRING" id="76193.A0A0N1IIA2"/>
    <dbReference type="KEGG" id="pmac:106709789"/>
    <dbReference type="InParanoid" id="A0A0N1IIA2"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="259" mass="27843" checksum="D6AC8B07A78DD73B" modified="2015-12-09" version="1">MSFNNKVVLVTGASKGIGAAISIKFSTEKASVILISRNEEKLQEVAQKCKDVGGNPLVIAADLTVDDDVERAIKTSIEHFGRLDVLINNAGFAASESILSKNALKVFDNIMALNLRAHVLVTHLTAPYLIDTKGCIVNISSIASTVICFRIHSQYSTSKAGLDAFTRSIAIELAPYGVRVNSVNPGPVKSDFMERMGLNEEQKKQLWDTLVKGTALNNIIEPCEVGDLVLFLSSDKAKSITGSSYVIDSGVLLKGMIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJA7</accession>
    <name>A0A0N1IJA7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IJA7"/>
    <dbReference type="InParanoid" id="A0A0N1IJA7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1429" mass="158761" checksum="95932332943FE5D4" modified="2015-12-09" version="1">MAPGERYSGLKSTSCEMCCQRTRHGAPHYHTRPDRARYIESKAIIGAAIGASSDDVIVLGASLPRLLRALRPQRVALFVSSRETERQLAPWREFNAEIIKIAESKDGFIDLNNLEMKLQENTGTGKRMIGFFPAASKLTGVFADDVATTLLLHQYGAWSFWDYTLVAPTSNVDMNPTFLGVEEGMVRKDALFFNCEKFVGGVQGPYVAVVKKDVFKNSPVYSDDVEVLSERIEEYRCAEAVRAALVVQLRDAVGLQNIIERQDNITRQVLSHIKNIPELILLGTESPTVKRLPIFSLMVKHPRGTFLHHNFVCAVLNDVFGIQARGGLTSNLNYGADVLGIDDQLLKEYEKLLDVEAQKEVARVRKLSDAKAPDVPIYNEHLRPGFCRVSLPYFMSDTELAFVLEALKMVATEGWKILPQYVVNTETGQWRHHTCSVLRERKSLYSLRYNDGQITAHERRVSGPGIFPQTYTECLQTARNLFNRARKLAMKCSSIEPEVTFNPRIDYLRWFMLPKEAHDLLLGRSANVKHIVPFDPSGYTGARKSLNFSRSSVTSSPIFGASSRHFSLSAIDDCQIFRLKQKQKFYSRESSLKETTKEQAVTVANPVKFALGESVSPLRIVPQSAKPMLGRSRCYSLGSDSPPVQLSAQTKMNLGLKETSPSSEEKTNGFCNCGSQTDLQSLDDPMLSPGKAYPFSTQSSTSISDCSQNGRISPTTSITSHTSEDIHAYVKEMTRELATEIKSEIRGVISKVDDILENSDSLDQSNVSLNSTSSQSEKNSVSVIDVAEYLMGMSREMASEVKHEIREMVNQVDEMISPDYGSCSRRSSPPQTGRRRIGSGPELGLDLKKSTQCLRKCTTSPVLPCHVDEEESNFGKGSPNVQSPKSGQGTPSHEAIGTNNISFNSSETSTPDTIIQVVTTSHNSPVLPKSSSSNKLSDDEVCADVACRHCCNKKICCQNPSVSSQDSGINMSYTESDAYLEFVKWRTSSDPTTNKLKKLQGRLRICKHEKNEVPDIIEGVPVCSGDKRPDKSDPASGRVAFQISDDVETQNVTTSTDWKRSSRCSNASSSCSERSSRSSGYGTDQHRTSHDDVCFDRSESECVHKSCWEEEHDDSSACSDSSLTDFTTDDEGKWYCPPKHVWKATVEAIHEHKMVRAGDKVLVCLSGRRDSVALLHVMHHYQYYARAKGQHFSIGALFVHEPQSEVDPLHLMAYCRSLGVKFIYEDKLDDEETSNSSKSELHRWASVAVRRRAYVAAQAHGYSVAALAQSLDTAATAFLASALYAAKLTTTKAHYRLRDQDLRIIRPFIYVRARSLEAFACARALPDFTAPAVATPLRTQHTDNASKSPEECECETDPLSAVRQLLASHETRHPHIFNSLKTALLPLIAARTVDRESAERRHRKKSVIQMKNGAPVADSDDGSEEEPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IL06</accession>
    <name>A0A0N1IL06_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047474">
        <property type="protein sequence ID" value="KPJ21446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IL06"/>
    <dbReference type="InParanoid" id="A0A0N1IL06"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="193" mass="22278" checksum="0AF1AE9ADEAF43F9" modified="2015-12-09" version="1" fragment="single">ISVYRPMLFFFLLVPSGRRIYKGERTKIKHYPFMASIQIFDVFQCAGSIIKSDLIITASSCLQLAWNNRFYRENPAFLAVRVGSSFYNSGGERIAILEIYFHPDYNPKNLWNNICVLRLERHIKFLKTNVKSVKKIAIDKNPWNLPVNTPGITIIGWGAKSTSNKVGDPFYNILSFSHLDVYPTRECQEVYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IN97</accession>
    <name>A0A0N1IN97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UHRF1-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ06996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IN97"/>
    <dbReference type="FunCoup" id="A0A0N1IN97">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IN97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="799" mass="86926" checksum="5FA52D7A6500C61D" modified="2015-12-09" version="1">MSIFDVSTGSKSRETPRPLVSAEKATLPGDAGLLHAELTFFYYPGDVCFPVPSPKLYVQLSPVRVSVDVPSVVWLSAFLPHVGRALATATAAEDQTSYIDVRTEAIMPKLVLEAGPEHVSQQRDRPKELHICTARATFTNVRESPRSNTAGTRADLASIISCLRRAAPHGGQFPCMPDDLDPIHEQFLLHADNLDDIDRGSAISPELLWRENRSVWCARVEPLWADFCGARATNYKPAPLLDATPLTAWLYFDEGFSRIWVIGRTCGLAGLQLNHYQLLFLLRTLERVAEMMAWLAHDAARQPDGDDGSIVVGIVVPAVELTLVLPSNCPGQESSRDLDSVPLDSSSLQDLKMGSEATMAPSMQDRDSAVLSLPAPIEVCSVQPLPAEEVPPSPGISFGGFSSMRRGLTSLVTSLDALGRDDSRSDAASTASSDSERYVLVGLAAESPDDADVAFREFEQGRMSTGVEVAAEVVERSSSPSDHSLASSCRRRDLISTCTWRLNNIHLVQQSSGGKSSLRLAADDLSTDECAAIPWDEFQVLIENVKLHLIEDRPTRSISSPPPQPLDLDLSSLRVTRDNTGVVYLGPPLATPSTVTSPATPTSQHDEAAERIEQLSKENEELRKRLVTLARIAEDNRELRAKVEEASVLKQCVHAAQQEAANLLADKQQLLDAVRVLQVSSSSANYSSPLKGSEPNPTRAWTEPVVDETELKTRDTPHVALRLIRNELPKQVDEKGESTGLAAYEELLEARVRDLSIALNMSTALALAEFIEDEIIAPPMPLEVTSDVSPLATDTPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INW4</accession>
    <name>A0A0N1INW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translational activator GCN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460784">
        <property type="protein sequence ID" value="KPJ12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1INW4">
        <property type="interactions" value="1851"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INW4"/>
    <dbReference type="InParanoid" id="A0A0N1INW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000162">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1400"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1576"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1653"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1695"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="2054"/>
            <end position="2091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2735" mass="298264" checksum="88256A7330BB44F7" modified="2015-12-09" version="1">MSEIVKDKDQRRLNVLHLLCKETICNKYTKLSECLQKMADTEVLKKLKDVPFKIQTASLKERREVLKEIQDVLATPGITEPAVRFVCRVVTSTLHRYRDTTSQFYVKSLLAYLSTNHREWTLRSFLPLLLDISENLRNTVTSKSTCQSGLFALHWSAVVAEASLKNTDEDGVDYNSLVLSQANLLAVVTAYGNKKKNNKAFTALHASWTAIGKTKTIKWFDVLTTLPTDSGPQIPIIFSALCRHFKQTGDEEIVTNHKAKMLDSFIKSLISVKNRPNANYISGCADLLHMVTLADVKDSLLPALQKAMLRSPETIIQAVGEVFANLVLFVDGTAVDIGKSLIGNLHSKDAWARVEANKALGHLARRCSALPAARPLLASVFAEYHGASGKLTSSEDKIAVLQGAGTLSELAVSEEDFTALYEEVTSQVSRVLDSESHERTLCVALDVLSLWTQRLRAPLHSKVYEIFKKNLSAKNSTPAVRSAYVSLLTRAVRGGVSAAHAQALRPTLLSTLERAAAQPPQHPIVNEAISAMLGLILMDEDRQLPSKTAVWSMLVHHDKHVLLQDRVLAAAPDDVLTQVVLLCSAALERYDVVASDGDSPVYRALVLVLLSTAKPVRSAALQEVSSLLAREDRAQVARFLAHKLNEVLEEGKIFTVKEKSPPEEKAEVTGKMIIDCVHAICSYRDYPSDELEGLAIDILPSCHHPVAAASGGGGRTWLRLLAHLRLQPRDLVARHCTQLRATYIDGYTPTPTMSNIVSSLVAANEQAVGGAALAAALDALREPDLLRVTRDEYFVFLTPPGDLYDKSVVPGNDDGKEMNLKRESKAYSYKEQLEELQLRRELEEKRRREGHAKQVPLSAKQKEAIKLQLAKESIIRDRLTALNERVVVAEQLVSAVQAGSAAAVCQQARHVVSAVLAALRSPLAAPRLAPLYLRLRPALLPRHALLGDTAARVALRLHKPQCDLEPCWEEEELGKATVRTIGLLHAATAEPKPSAEADASAPPHAPANHFTAPGFCYIFPLLKQGLTGPARGDEAAMVSGLAVIARHARLRGEPHDPRDMLRPALFPIDHMFRLLIDVISNTSKRVQAAATLALLETAECAARGDLSLDDATCLLAGLQNPQEVVRDAALRALLCVADCLSPLLDDLEHGLEITKRLYIATFDVSEDNKKLAYELWSKVPRAEAWLSGAEAELVRELVREVQHPAEPVQRAAADALATLVARADSEDCAPSRVMHMLHDLYEEKYPLIPAKLDQFGHERESAVDEWGARRGAALGLRALAPRLTAEDVPAATAFFVQRGLADRRDEVREEMLAAAMAVVDLHGKETLSSQLPVFENFLDTAPKSGGYDAVRQCVVLLVGSLARHLEPHDARIRPITLRLVAALSTPSQPVQDAVSNCLPHLVTSPALAAEIQPIMNKLMKQLLTAEKYGDRRGAAYGIAGVIKGLGILSLKQLDVMGKLTEAIQEKKNYKYREGALFGFEILCYKLGRLFEPYIVHVLPHLLMCFGDSSQYVRAAADDTAKLIMSKLSAHGVKLVLPSLLQALQDDNWRTKAGSIELLGAMAYCAPKQLSSCLPSIVPKLIEVLSDSHTKVQEASVEALGVIGSVIRNPEIQAIVPVLLHALKDPSNMTSACLQTLLDTKFVHFIDAPSLALIMPVVQRAFQDRSTETRKMAAQIIGNMYSLTDQKDLLPYLPNIIPGLKSSLLDPVPEVRSVSARALGAMVRGMGESSFEELLPWLMQTLTSESSSVDRSGAAQGLSEVVAGLGVEKLHKLMPVINFVVRVWGGDIIATAERTDIAPHVKDGYIMMFIYMPGAFTDEFTPYIGQIINPILKALADENEYVRETALKAGQRIVTLYAESAIALLLPQLERGLFDDNWRIRYSSVQLLGDLLYRISGVSGKMSTETASEDDNFGTEHSHRAIMSALGAERRNRVLAGLYMGRSDVALMVRQAALHVWKVVVTNTPKTLREILPTLFGLLLGCLASTSYDKRQVAARTLGDLVRKLGERVLPEIVPILERGLRSERADQRQGVCIGLGEILASTSRDAVLSFADGLVPTVRTALCDPLPEVRMAAARTFDSLHATIGNKALDDILPPMLAQLHDADQQRADAALDGLKQIMAIKSRAVLPYLIPVLTGTGSGPGAGGGADTRALSALAAAAGSSLSRYLPRVLPALLAALLAARGSPHEARELDQCRDALLPVVDDAGVRCIIDMLLEAVRTGSGERRRAAAALLCAFVSHSRADLAPHVPQLLRGLLLLFADTDRDVLQMAWEALSALTRTLDAERQMQHVSDVRQAVRYAAADLKPGDLLPGFCLPKGIAPILPLFREAILNGLPEDKEGAALMLGEVIRLTSAAALQPSVVHVTGPLIRILGDRFNAAVKAAVLETLAELLSKVGVMLKQFLPQLQTTFLKALHDGSRTVRIKAGLALSQLVLIHTRADPLFVEMHNGVRNAEDAAVRETMLQALRGVLTAGGQKMSEQLALAVLATLTTPALLAHPDDPPRSAVGGCLGALVQWLPAAHRDAAIAHHVLGGSPAEDWLLQHGRSCALFVALKESPQEIYREPFLERVERTLLAQLASERAPVACNAVRGIGYLARYLLQHDRPVPHNLLSQFVRSMNHSSNEVKQLMARASALLGREAPLEACGGELLRALLPALVNGTKEKNTYVRANSELALRAVLRLPQDEHFHQKCLVLLEEGAREALSDVVARVLRRAHSDVRDARDRDEDLDCTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INZ4</accession>
    <name>A0A0N1INZ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INZ4"/>
    <dbReference type="FunCoup" id="A0A0N1INZ4">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INZ4"/>
    <dbReference type="KEGG" id="pmac:106713330"/>
    <dbReference type="InParanoid" id="A0A0N1INZ4"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="654" mass="75382" checksum="8D40016F6C3C41F9" modified="2015-12-09" version="1">MTNSIVGRLAAVRFRYKLLLAAISSGSFLMLILNNSTDIFGDKREVSTIWYSTHRYDPFDSGAGFTIKTEGCTIPDLHPFDESIRKFIEYPTHLKPCKNKDISLLKNNETHIWLAPENIEYPSVTNITCCYKAFYRPLSISDISSADIDDRVKYDECVYFYDYIEVTNEFVKVSCTNHDKVILYEQFYIFAMKKPFLSYKEDSTEAPINQSGYNVLVMGIDAISRLNFYRTMPKTLSYLKKKGAIELFGYNKVGDNTFPNLIPILLGIRDTDLKRTCWPNVRATFDNCPFIWDWFKEAGYFTALGEDSASLGTFNFEKLGFSGTPTDYYIRTFVHEAELRVGNNKDFNSFICMGNKYFYQVLLDYIEDLTKTLKSSKLFGFFWEVTMSHDYLNYPVIMDESYETFLKHLDISKYLEDTILILLSDHGIRWGDIRLTKQGRLEERLPLVHILLPTSFRENYALAYDNLKLNSRRLTTPFDLYATLSDLVNMDSIKNDKVRHRSSSHYAQDRSISLFLPIPSNRTCSVAGIDDHWCTCLTGRRISTTSKEASAAGAVLVRQLNVMLRPHRQCQRLLLAKILEVTEMEVGKPEDYEVGWREFIVTVRTAPGDGLFEATVRRRSGGWLLAGTVSRLNLYGDQSHCVHDAHLKLYCFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PF12</accession>
    <name>A0A0N1PF12_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PF12"/>
    <dbReference type="FunCoup" id="A0A0N1PF12">
        <property type="interactions" value="1949"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PF12"/>
    <dbReference type="KEGG" id="pmac:106717444"/>
    <dbReference type="InParanoid" id="A0A0N1PF12"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="56525" checksum="4E2240C446F62E76" modified="2015-12-09" version="1">MPNEDRELFHNFITKLQTENDIKPILNDIKNMFSFKPPSNAKNTLTCLGVSNIIRCLDVQDKANVDLTCEVLKVCFDKFGAGDVIKHFTGHIMYLLRHDKDCVRRLAVDEVFKSVKTDQTSFPVAQHIDVFVAVAQMICDKDVGVANKAVTITSNLPPEVYPKILEEMKIALDENSSSKCNAYEVVCNIAMKSPELFTLCVEQGYIDHMISELSTDDILYQLNILELLSRFAVKPYGIHYLVKEGGLDKIATLIGDVQSNPLSGLMLPGYLKFFGSIAHHYPKEIFAKYPVFLNSLFEAIESSDQSVQLPVALDTLGFIGTTIEGKLCLAAIGAQFIQAVDKVGDLIKNGITEIKIRALNCLASLISVERDKAKSNPVDHRVTLMTREWFRSLNKPNGAMEFLFETVKNPFPDIKLAAFILLDAVCQHMWGEQDVARVAGFVEYLLDRSVSDTKEAKEARYDIIKRLAHSSAFESNILTRLQKYVVEGPFYMETNLQVAMEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG26</accession>
    <name>A0A0N1PG26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-tocopherol transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460622">
        <property type="protein sequence ID" value="KPJ13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG26"/>
    <dbReference type="InParanoid" id="A0A0N1PG26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="284"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="404" mass="47373" checksum="4B630A095A968109" modified="2015-12-09" version="1">MPQDLQQEVISIREWLAKEPHLPKDLDDFILEKFLHSCYGSLQKTKKCIERFCSTRSVMSEIYILRNPISPSMETAFSITNVSNYEAGENEILIHQFEDPTLEKFNFYDILKSFSIQADMWLMEQKFLPEGHIIILDMNNYSLRMIPRINIFLIREFFMYLLEGMPVRVKQIYAINAPSFYDKLFALIKPVLPSEICNIIQFLPDCQSLHKHIDKKYLPSEYGGEAESMKAQHKNWIDQIQKARNFSYEHSHTIHGRNTDEFHTNFEIYLNNNDCIYLSGNMAIYLEAMPVRVKQIYAINAPSFYDKLFALIKPVLPSEICNIIQFLPDCQSLHKHIDKKYLPSEYGGEAESMKAQHKSWIDQIQKARARFLNDNLWKADLKKKSKNNSFENTMNGSFKTLCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG44</accession>
    <name>A0A0N1PG44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine protease gd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG44"/>
    <dbReference type="STRING" id="76193.A0A0N1PG44"/>
    <dbReference type="InParanoid" id="A0A0N1PG44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="401"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="686" mass="75786" checksum="D898DD1F8CCA7F9D" modified="2015-12-09" version="1">MERPPKRSKSSVTSQSGNNNEVTARAEAPEGALEPRWQGANSEPLATNCLALVSHKDRTIRTVSYLVVALAASCSAQSTSSSGSTPRSPCPNVFQYEPSGTEPGRWYGVVNLSTDSTLHSLWLNVVLDSKADILGNWVGDVSTTDNIDFKIENTKMKIHPGPAVAVRFFVQYNPLKTPIPRLQTIRLNGREICNANTPVPADSILDSTSSGQSRPETGRPVSTRPVERPVERPVASRPVQSRPSESRPVQSRPSESRPSIRPSESRPSIRPEDTPVTRPVHGTPSSSGPVYVPTANPPIDQINVNPFVIGEGGKGQSGSRPNSVFGHTTSSYTTTTTDSAEFEDFDTIKRPDPNDYFGGGLHTIVVPNNNDDDFNDNNNNNNRYPKSRCGKVTLNKPNPLVVNGKPTLEGQWPWQIALYQTQTVDSKYICGGTLVTHLHVITAAHCVTRKSSSRVVNKNTLTVYLGKHNLRTSVRGVQIRLVDEITVHPQYNASSYSHDVAILRLIEPVQYTDYVRPACLWPDEQTDLNSVIGKKGSVVGWGFDETGVATEELTLVEMPVVDQETCIRSYSDFFARFTSQYTFCAGYRDGTSVCNGDSGGGMVFQMNDSWHLRGLVSLSVARQNEYRCDPTHYVPYSQTTKEADKTKAEEEEVIYILLLPDWEFKCPLHDQVVKTPRWVFVTERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGH2</accession>
    <name>A0A0N1PGH2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 93</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGH2"/>
    <dbReference type="FunCoup" id="A0A0N1PGH2">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGH2"/>
    <dbReference type="InParanoid" id="A0A0N1PGH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039116">
        <property type="entry name" value="CCDC93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019159">
        <property type="entry name" value="CCDC93_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048747">
        <property type="entry name" value="CCDC93_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16441">
        <property type="entry name" value="FIDIPIDINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09762">
        <property type="entry name" value="CCDC93_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21673">
        <property type="entry name" value="CCDC93_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC93 N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC93 coiled-coil" evidence="5">
        <location>
            <begin position="349"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="494"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="545" mass="64316" checksum="725A97B9A3783630" modified="2015-12-09" version="1">MGILLTTKDSLQFVHDVEVREDAEQIVKWHEICDALVAAGYYRAQLQGLSAFDKIVGGLSWCIELCDIDVDISLLFEENLTIGKKIALTEKIVKILPTMKCPYIIEPHQIQGLDFINIYPLIQWLIKYSSEFREVKEDELRKFAVMQYDKDHIFESDRAYYLQKEKLLRNLSTVQDLYKPCRVRKRKGGFPTNELEQVNAVLSEYDQRMLMHVTNNHDDSQRDEGLDFLYDYEKTLADPSEVTTETDRHLNIKGSDNVSTDTKIHYVVLHSELTGDIPKELEESEKIKYSQDITTLTDCIDKMEKEVETIKKKHEQRMQDSKQQYTKTLSKLKKITQNLMKSDNYSDKNVKEFYASLKDLARERNELLKIIQHRDMQYKKLEEELSTRLELGKLNRQILRYTVAIDEIPGTAELLQYEKRFVELYNQVASKHKETKQYFIFYNTLYEVKLYTSKELSLLNSILDNYEEAMSSTRKREEFMTQFESIVDWVNQTVKKVEEKFNSEKARKATLHNEYTRLIEIQRQYAAALKKLAAERQKISRHMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH79</accession>
    <name>A0A0N1PH79_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Serine protease easter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_01657</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459999">
        <property type="protein sequence ID" value="KPJ18497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH79"/>
    <dbReference type="FunCoup" id="A0A0N1PH79">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH79"/>
    <dbReference type="InParanoid" id="A0A0N1PH79"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000078">
        <property type="entry name" value="Serine protease H137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="134"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="535"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="861"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ18497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123973" checksum="3B826F49B04857DA" modified="2015-12-09" version="1">MPNGNAGECKIMKKCKPLYELDKKRVKTDNEMLYLGQSLCTTTSSFIAVVCCPPESQWSDFNGIKPVLYKEFKRYDTVLKEKPFSDNGIKLDSRVKKDDRDPPNNRNQDNISKVPPIQDDNIECGKDVSNSNRIIGGGLAGIDQYPWLVLLEYAKGLTLCGGSLITSRFVLTAAHCLRAENLPLFARLAEYNTSSYPTDTVETDGGGFDNITVEIVRIERSIRHPNYARAYHHDIGLSKLERAVHFTDFIRTICLPTQDYRKTFTVPLNFTVAGWGSDGSKVSEVKKHVRVPYVPNDQCRERYSLKIVDSQMCAGGKRGEDSCSGDSGGPLMYELEDNNTYIAIGVVSFGYKECGTVNVPAIYTYVYEYLDWIKDNMRQLDARHDDLKARPLAAISYNSVIGILSCPQHKQCRMPNGNAGECKTMKKCKPLYELNKKRVKTDNELLYLRQSLCTVTSGFNAVVRLVKPLTTVPPTPSLEQKFVTISDNGIDLDTRGSKDDRDPPNNRNQDNISKVPLIQDDDTECGKDVSNDNRIIGGGPAGIDQYPWLVLLEYAKGLTLCGGSLITSRFVLTAAHCLRAENLPLFARLAEYNTSSYPTDTVETDGGGFDNITVEIVPIERSIRHPNYTRAYLHHDIGLIKLKRAVTFTEFIRTICLPTQDYRKTFNVPLNFTVAGWGSDGSKFSEVKKHVKVPYVPNDQCRERYTLNKIVDSQMCAGGKRGEDSCSGDSGGPLMYELEDNTYVAIGVVSFGYRECDFIKPTCLPTKNFTAELAESQGLTLAGWGSNGTDRNTIKMEVCCPPQSEWSRKLDLKPISFPEIINYLAEPGSNGTFEKSNNDKKTTTVLREGINKETEECGVEVSGAKQDRDYGTADIDEYPWLALLQYRFGRIMCGGSLISPNFILTAAHCIETTHGRPAFARLAEYNMTSYPIDYVEVDGGAVESITVSAIAIKWSEKHPMFDMNTYQHDIGLVKLAEAAKISDFIRPICLPRYNFADQFDTNTNFITAGWGVHSSINNDIKMEAKLPYMPIPTCKRTISTTSLTNKQLCAGGKNAISDCVTDSGGPLMFVSENYYIVVGVASYGPANCSNIREPTVHTNVYEYLDWIDSMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHC8</accession>
    <name>A0A0N1PHC8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHC8"/>
    <dbReference type="FunCoup" id="A0A0N1PHC8">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHC8"/>
    <dbReference type="KEGG" id="pmac:106720830"/>
    <dbReference type="InParanoid" id="A0A0N1PHC8"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="344"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="447" mass="50508" checksum="4EA55751B640518D" modified="2015-12-09" version="1">MSNLLEVLVTSDSNNTMWTCCVWDPHNGTSLMTYKGGGTAELKTLSFIGNDYLVAVEKAKPILHVWPLNSHQTVQGMRFVLPGKANAFSISKDGSFCAAGIDEKIYLWQVASGNLLTILNRHYQKVNLIKFTSCGRYFVSAAEDGMVMVWSLAAIATHPEVELVNQVRAGQHDPVYIISDHSLPVTDLCISKMGILGRLYTVSSDRTCKIYDLTTGDLLLNLVFDIPLSSIELDVLELNVFVGTMKGDIYQFSLTNPIRNKELLMSEENSLIFSCHTDAITSLSVSLDGETLMSASNDKQLILWHIRSRQPIKKIMHKGSITNAFFTLNRPAIYTQDFKPKVILHSLERTLEKDNDEITELEILIDKKINFWPEHQDISLEVETPLKETGIELKKQEKLLREELNQLKWINQSLYAYTVNNTLNSTITKDVQKPTTNKKKKRKTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHQ4</accession>
    <name>A0A0N1PHQ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460735">
        <property type="protein sequence ID" value="KPJ12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHQ4"/>
    <dbReference type="InParanoid" id="A0A0N1PHQ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="12500" checksum="7AA0B4F0ABE7D71D" modified="2015-12-09" version="1">METIVALLSIVYVMYQYRRLIFKCYYDGCDEDEYGDYRPRLSRSRSRSYSRSRSRPRSTSSYRNYKMDDTKNSRRGRKSQRRGHNYNDEKFPPWQKVSETRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIG5</accession>
    <name>A0A0N1PIG5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="EMBL" id="KQ459718">
        <property type="protein sequence ID" value="KPJ20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIG5"/>
    <dbReference type="FunCoup" id="A0A0N1PIG5">
        <property type="interactions" value="1645"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIG5"/>
    <dbReference type="KEGG" id="pmac:106708748"/>
    <dbReference type="InParanoid" id="A0A0N1PIG5"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="20443" checksum="83BDED0A4C151725" modified="2015-12-09" version="1">MTRAKIELGDVTPHNIKQLKKLNTVVFPVSYNDKFYKDVLEAGELAKLAYYNDIVVGAVCCRIDTTENSRRLYIMTLGCLYPYRRLGIGTLMVEHVLKYVEQDGNFDSIFLHVQVNNEGAIDFYKKFGFEIVETKEHYYKRIEPADAHVLQKTIREPQTTAPLVNGSVPHAKTNGLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIS0</accession>
    <name>A0A0N1PIS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIS0"/>
    <dbReference type="FunCoup" id="A0A0N1PIS0">
        <property type="interactions" value="602"/>
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    <dbReference type="STRING" id="76193.A0A0N1PIS0"/>
    <dbReference type="KEGG" id="pmac:106709275"/>
    <dbReference type="InParanoid" id="A0A0N1PIS0"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13337">
        <property type="entry name" value="FERM-like_C_SNX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06885">
        <property type="entry name" value="PX_SNX17_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000001">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000145">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000008">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048767">
        <property type="entry name" value="SNX17-31_FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037836">
        <property type="entry name" value="SNX17_FERM-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21271">
        <property type="entry name" value="SNX17-31_F2_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="483" mass="55118" checksum="6FE2DF19C4905F2D" modified="2015-12-09" version="1">MHFSIPDVQQFRDDNGITYTGYNIYIDGFFHCTTRYKQLLSLHEQLQAQNPYLKLPQFPPKKLFLTNSQIEERRILLEKYIQLVGQNPILAYSDILTTFLFSAQQETHCVRVHEVDIEIFLMNGYRIPLSVSSTDASSVVLDIACNYINLSKDFEKFFSLYLFNWSCAKDGQPCLKKLEEYESPYISQKYVRPDDKIVLRKSYWDPCYDMDVMSDRVSLDLLYLQTIQDIDLGWIVVNSQTRDILNSHESRKEKKEYIEVARSCRYYGRVPAGEAVTEAQHVTGGATSGAGGGPCRVHVSLASKELTLTTITQPVREQRYKVTRMRCWRITTLHTMEKPQSNGHGSLLEDTNKHFELSFEYLISKDNLEWITLRTEHAIFISVCLQSIVDELMRQKSGCGPSSPRCKRGGLTYLRRDGSSQLITPSSSSDTLSSVNGDSITSGSSREIFSVQKLTEKFASVSFKTGKDCVENNAFEAIGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ49</accession>
    <name>A0A0N1PJ49_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ49"/>
    <dbReference type="STRING" id="76193.A0A0N1PJ49"/>
    <dbReference type="InParanoid" id="A0A0N1PJ49"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF40">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="20181" checksum="319927D5FAD95C86" modified="2015-12-09" version="1">MFKETYSWSSGACFRYDALQLDLSGFTSACALLSLTTRFHEAIGETIALSVASPRHLQTLGLVQKSIDDTAHDINYLFTQAMDKLAFLPFALVMDKWRWDVFTGDIRKEQYNCHWWRLREQYQGVKPPVLRSEMDFDPGSKYHIPANIPYIRFFDYGNSKIENFSSFNETNIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJB4</accession>
    <name>A0A0N1PJB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460389">
        <property type="protein sequence ID" value="KPJ15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJB4"/>
    <dbReference type="InParanoid" id="A0A0N1PJB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="7053" checksum="3F42F8B68E343710" modified="2015-12-09" version="1">MSDRLKNTNTISNQEVIEDLTKDLEFLSADETTANDINPETTVDDFINSAGDAQKTGKDYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJX7</accession>
    <name>A0A0N1PJX7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034715">
        <property type="protein sequence ID" value="KPJ21270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJX7"/>
    <dbReference type="InParanoid" id="A0A0N1PJX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12330" checksum="885E3339E63042A0" modified="2015-12-09" version="1">MRHDFLEPIMTILPPAPEDLLNTIFCNCKSGCGSQCGCRKAGLQCSLTCGQCNGQACLNALPYQSDINEDGTFDPEIMEELETNVVEDDNEDQFEIYQQPEDDDEEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLI8</accession>
    <name>A0A194QLI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLI8"/>
    <dbReference type="KEGG" id="pmac:106720033"/>
    <dbReference type="InParanoid" id="A0A194QLI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="15370" checksum="0230D8F2EF8BA9BD" modified="2016-10-05" version="1">MSLRSLSKGRFLIAILIFTFFVWIAYLYLNSLQSDYNSTESGNRCMSELTSIKYQLNVVTEYKNRIDRLLTETQKAREADKGRYKDVLESCGAMKQHIAICQSQFEDLQSECKKVKEDYDKLKIDAEKIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM98</accession>
    <name>A0A194QM98_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_11710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QM98"/>
    <dbReference type="InParanoid" id="A0A194QM98"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="707"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1422"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1889"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2003"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1422"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1446"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1894"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1910"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1921"/>
            <end position="1937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ06663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2023" mass="229625" checksum="598DCBB807BFC231" modified="2016-10-05" version="1">MIIALQTLIYFRESLLTILDRLIGPYYKRFSLSLIKKSSSSDDEDSDEQVFSEFDDEKGVIFFPPMYVQRYAAVNDCLLDERWNGKLEKIVDLGYHDMTFIKYLKEVPGVKHILGVDIENVSLRCSPDIICDGEYAPRRETPLQITLFEGNAADPDYRLIGCDAVVAIEMIEHMLPHDLDRLVHNIFGFIQPQVAVITTPNADFNVLFKSMENNGLRRWDHLFEWSREQFNDWCSNIVLRYPNYTVTCKGVGPGPPGTEHYGCCSQLALFVSKNYQKQPSLTIDSMALVKSLPNDNNLSDVESWDYTDSIHESNMLCAPPNDESFTELPFPEKRSCMTIVILGSPPIDTLVYKDNTSQCNIDREIGRSYLMFDEDVSENIVVPRRKVINRVYEIEDVSSRLHCSMLQVRKFSKTTQNLMAKNKLDSVMHTREIVDEIRQLTKTLNLNRNTLDQQQPRACRLQVKDLLEWNGYEVVDNIVIHSRLIVENVSMTTPDNEYQDNDALSDVKKQFEFVDVDDWDMTEMHSTSYSNASSNSSHPNGKWLQRSLDFKVRKLRNLLTADEDISTELDRVVCRLMKLAITTHKNKSVPPPTSWLQCKLLDLLTLTERAIQRRKRYYFNQNPSFTFGDYQTTRTREIEPPKSNDNESTNEIMSKYTHFVETTDEKEYKNTTVGAYQYVHLQVEDDDMSVTSNELVKAYDYNKQECSASPSYGKLKTNKLNSNARDPSPARTYPITDNYSGVSSSGDTDHSIKLSNDSRSKKSSRKSRRETNKDKHKIKLFIKKSKKGNGKETKYNEKYAGNAEKKIYFKRTIKKKSFCRCSIKNSVSSAECESNKVRNKRRCRRNHQISSMSKPIPYSLVKLCTPKDNDKTKKLAEDVTPVKSNNSEHLLRRNQESIAITEQSCVIEIVTNKTSETLALHRTITTDLSNSIYKNNLLPLEFKDRLDIVPVITKSESSIPEITLKSEKEESQAIFLYDINEPSTSKGIRHITMDVQCGPDTGFVCPYTSATSLNNITNDNTNTTYLKSYIDKCEQSHYYTKPEDNNDVKSDNVISSRVKSNGIQIKDSDNSIDKKLEISTKTVTKSIDAIETFKDSPDNICNDSTDIVTSLRRVCDEVSNIIKSDKPYPQSPQNVISKLYGNEDEDDQCKCTYLKPIIDLPQVINSTETEQFLRKDIDFTNSICNIGNGNLTYGGIFIHSYKERTECEDILYQGKWQRSLSKTFMKKNPVTTFTLKKTTESHNIKRRNSKLSLTAKTVGKKNEHSRSSDKLRKISDLLETKKNINVSSNNKNLAKKKPLVELCKPTRRRKTLREVASKTVRFDLSKNTRFERVTVKSSKSKIYKNSKKDKKKVVTFKESHSKCELNTTNELLKALNYTEEKGNNDFPKNLTNTLNVKKELMKFVREPHKKIVYSVFRNKIENETDNQRHSKPSIENRKNKEHKSARNIQAANSSSSSTNSIVTIRQLSPPSQNRKKFTSKITLKVSNNPKASSMKEKHSVPVCYNKSSIIFDDKENNPQSSNVRNFQCNKENTHDVNEISKSILMSRNVISKQKNKSLIIKKSIENIEEKLAASDSTNSSKVSSVESIKNQSNFNANSSNSVLVLGSYKNLPTMDSEKLSPNNILCTSENNQEIVHTSIIQLSCKNNEMNISNSISDETVYNEMMTVVDEMLNFIDDPERKSILTVESKKMIPDERKKSGEKVHFYNAPDNESIATSLDSGPKQVNLDLISFKSFASLSGYSEYFLADSELSTTIDSLQVKTPSKRSSVQDIFERNDQTRLPFPGDSVQGFSGFSINEQVIGDQPDYANLINPETGIMETRRATSEEVFTSGRSSDTYESCQVDEDALVPNWLFHAISQQQSDEDREPQRILSPIPMPTVEPDLDLHTNVMEPGVGGVGGAAGAGAGDGRGIHSDQDSSGRDTSMSSTETSSGQQSDAILVDPSAYANNIEFLREPSSRPFLQLGSTESPDSSFRTVEGSENDNLFNMSEISTRNNLNLGAVQSDRDADVSSLDTDTADFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN40</accession>
    <name>A0A194QN40_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lysine-specific demethylase 3A/B tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN40"/>
    <dbReference type="InParanoid" id="A0A194QN40"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific demethylase 3A/B tudor" evidence="2">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific demethylase 3A/B tudor" evidence="2">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="577" mass="63340" checksum="45B718E3B780B8E2" modified="2016-10-05" version="1">MELERIQVLVEYDGVDWQRREWVAVHSRRTFRVFLVERTLVWAPKKYENEEVKWPALNLLGSTAENVSCLGGRTGRAGDTYRSDEMVYLIHVSPRPLLDANLYESRLTFFTQRRRSLRYPPWMLLSKLTVSLSSSYTTARFNSWTMPTFNHSSCPGVVGRSRTMSAKQGGGFPRETGSSGRARFEADLARELCFDVPRLPDYHPSPATPRLVPAILIFRAHAAPSPLYYIHIQEAVVASECASSKGAARKLNEGPGANDWDARLAGSEAGVGADLLSSLCAESAEWRSAQDGQRILTSTPSVLGGCRAQVYRVAGATQWYTAVIVGVNEHTGLGRTVNCIYNMCVASALVGRLRTGNSFHSCIFFRQELTVTDDTVLEEHSEDPALVQMRLLGDGVIESIMRGEVVGVMPRRSRSNLQIRISIATSAGCRGSSGAPAYPSNPILSAPPSRLPRTPPIPHTRCCRFTLFWLVSGCGGCARAAEQWRGAGDAVGGESPLLAPGPVCAILPRRHDTNTLCYSLLRKRIERENNKSPATTGGRKKQAAVRSNGQIAAVEPPPQQQTGKVIHKSYNCDFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN58</accession>
    <name>A0A194QN58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN58"/>
    <dbReference type="FunCoup" id="A0A194QN58">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QN58"/>
    <dbReference type="InParanoid" id="A0A194QN58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="32622" checksum="41175AA3F990FF73" modified="2016-10-05" version="1">MTRKVSECQAETLQFMPIEKVEEECIMEKDYCSSTTLLRRGKRLEDNNNITKEDILYINYRQLLKYEEAPAYLQHNPFIRDGYRKLLPTKLCWESIFWWTNETMNIWTHIFGFFLLLFLTINDLVIINIHATLTDKTVAAILFSCFLVCMALSALYHTFSCRSESDYNTFLMYDLFGIALSLLAIYTSGVYYAFWCHHMFFPRVIGMYVISGTAFAIYAFKIPERWFPGKVDYIGHSHQWWHILVLGALYYWHNSAMIYVQYRMNHGCANTMRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPL7</accession>
    <name>A0A194QPL7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPL7"/>
    <dbReference type="FunCoup" id="A0A194QPL7">
        <property type="interactions" value="1233"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPL7"/>
    <dbReference type="InParanoid" id="A0A194QPL7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000030">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264537" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="476" mass="53872" checksum="5D9F140E80C6FA0B" modified="2016-10-05" version="1">MRVTLFAVAIALLGAAFADEIPTEDNVLVLSKANFENVISTTDFILVEFYAPWCGHCKSLAPEYAKAATKLNEEESPIKLAKVDATQEQDLAESFGVRGYPTLKFFKNGNPVDYTGGRQADDIVAWLKKKTGPPAVEVTSAEQAKELIAANNVITFGFFPDQATEKAKAFLNVAGLVDDQVFALVSDEKLIEELEAESGDVVLFKNFEEPRVKYDAKEFNEDLFKTWVFVQSMPTIVEFSHETASKIFGGQIKYHLLLFLSKKNGDFEKYLDDLKPVAKNYRDKIMAVAIDTDEDDHQRVENIIKNGDFEKYLDDLKPVAKNYRDKIMAVAIDTDEDDHQRVTCYDDFEKYLDDLKPVAKNYRDKIMAVAIDTDEDDHQRILEFFGMKKDEVPSARLIALEQDMAKYKPASSELSANTIEEFIQSFFAGTLKQHLLSEDLPEDWAAKPVKVLVATNFDEVVFDTNKKVLVEFYAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR83</accession>
    <name>A0A194QR83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Wiskott-Aldrich syndrome protein family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR83"/>
    <dbReference type="STRING" id="76193.A0A194QR83"/>
    <dbReference type="InParanoid" id="A0A194QR83"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11186" checksum="B15A7F5FBF6AA448" modified="2016-10-05" version="1">MPFVQRVVEPKFLSRTSLRDEDGRPKVTDEELQAVTNCTLSNALRQLASLVLLAEDIFSDLTSQLQEITERSKVARAKIEKINESVEKYDPKKVPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS70</accession>
    <name>A0A194QS70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain phosphoinositide-interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS70"/>
    <dbReference type="FunCoup" id="A0A194QS70">
        <property type="interactions" value="2097"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS70"/>
    <dbReference type="KEGG" id="pmac:106718143"/>
    <dbReference type="InParanoid" id="A0A194QS70"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="38573" checksum="3AF34976799C1C33" modified="2016-10-05" version="1">MNLSDDNMFSNGLLYVGFNQDQGCFACGTENGFRVFNSDPLKEKERQNFAEGGLSYVEMLYRCNYMALVGGGKTPLYPPNRVIIWDDLKKDSAISLDFNSPVKAVKLRRDRIVVVLENLIKVYTFTAQPLLLHVFETCQNSRGLCVVCPNSNNALLAYPSRKTGHVQLVELSNQAGSSDTPEGHLISAHEAPLSCLALNVGGTRLATASTKGTLIRVFDTSSGQKLAELRRGAHQATIYCINFNHSSTNLCVTSDHGTVHIFSLEEDKLNKQSTLATVNFLPKYFSSNWSFCKFTIPNGPPCICAFGVDKSSIIVICADGSYYKYKFNEKGECNRDVYAQFLETSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSW1</accession>
    <name>A0A194QSW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSW1"/>
    <dbReference type="FunCoup" id="A0A194QSW1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSW1"/>
    <dbReference type="InParanoid" id="A0A194QSW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="984" mass="112448" checksum="62F6C633F6A98FAD" modified="2016-10-05" version="1">MVKKHRIHRRHGDILNETPEEDIRDALKQQTEQQLALVPHGPELVKDTVAYNTTIKTDDTRELRALRPDGTLVTETRHTREEERLCDEDLPEQEAGGIASDESVVEERGGTERRRREDLERSTDLMAGGLRLATQIHSRTRTEEVEREGQPNMEDDWDSLSVRLRRQRRLRLNDQQDYAKRPLDFDIEEETRKKETSKWLESHFGSDSRSSHDSIAEEIGRRPEPAYYVKNKSADDEGYYGKTSSSVPPPAAYGDRVLRKTKSSTPSDERPTGPVNRTGGYFKGVADWSQRRATKPRMPEPRSSSPSPPAVRSPYASDDRLNGSSPRHVYGKRDSPQGRSSPIGRRHPPSRDDSAYVSSSTMHSPPRGSPFRPLETDRSFREPSIEDDYRHPVVPERKRHTKQRVSEEHRYDSGYRSSSRNGNSGRSRDSREEAVAEPPPDYSPPRERRGSLDRDRTPPRRRDERKQNQKTRFAENEGRRRPSPVRKSVGSAIGNSIRKLVGKIRSASAERRTRWRNSRSPSPSPEHSSRTYKQYGGELAPPVAPPHRYYLGEDPFAPSIYGREHKYEGSSRRAATNDARDHRDRGQFSSTLGRFSHSTSRLNPNSEPEEEYSRSAQTLPRKLHDRKEKTTEKPTTNKYWNRLSSNKRSTSAINISNNHVAPPQEVKINGYPPGPAKPARTYKGLNRSKSFAMGAPEQETHPRYVTGMNRNYSTMYKSNPHLSKLDETPEQLKSPGIVSIINRSQRDLADAVSRETERRRDGLFGARYGKTAPISNGHTNGYNKSYEETDKKKIFLKGLRERAPDLYQTLHADDESDGSRLSSRYGTPSPHYKERISEERKIPLYKTESLNRESSPFVSRLETRLKSPAIRRGSNSSDNFSETYRYTTRSGDPERPSVTDTVETVSKKIVPSRDGRSKEIIESREVNSVTKSRGYKGEPISSVKYYENGIRASPPGYELKNGSAPLYSERRSSNYKVIEKMRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSY6</accession>
    <name>A0A194QSY6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="2 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5 6"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSY6"/>
    <dbReference type="FunCoup" id="A0A194QSY6">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QSY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11479" checksum="B736162C84DD8145" modified="2016-10-05" version="1">MSNDSDKQGLVSVDYEVFGKVQGVYFRKHTQRKAAGLGLKGWVKNTAQGTVVGQLQGPKNAAREMKTWLREVGSPKSKIEKVAFKNECPIATYTFKNFEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT63</accession>
    <name>A0A194QT63_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein D54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT63"/>
    <dbReference type="FunCoup" id="A0A194QT63">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT63"/>
    <dbReference type="InParanoid" id="A0A194QT63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF14">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="359" mass="39858" checksum="F8BD4727DC7F04BE" modified="2016-10-05" version="1">MANTREVSAEPASLEYMEDPYFVPPDDDSTPSFDVAVDELDELEDLASWPRDTEAEEDWRALPDLADSALCIETEFYMDNRRRRLRIFRKKIREVRVTFQDLSKPYLAKVSSHTNYKKFLGITPGAEEAMPGAGAGAGGGDAHTPDELAGLSPEQVEQLRAEWSHELARVEDEIATLRTVLQSKIRQSSELKRKLGITVWKEITEDVNQGLKNVKESQVYQTIETRVAALTQAVTEAPIYQKTESVIKSTAEKTTSILGGITAGVSSKLGQMRNSDSFRSIEERVGTAYENVKSYLGQMRNSDSFRSIEERVGTAYENVKGKVASRSNSTQSFDEALRDASRAASGATSPTIPEHKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTB6</accession>
    <name>A0A194QTB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTB6"/>
    <dbReference type="FunCoup" id="A0A194QTB6">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTB6"/>
    <dbReference type="InParanoid" id="A0A194QTB6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF2">
        <property type="entry name" value="AGAP003037-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="39043" checksum="EB4EEFF4584AD3D7" modified="2016-10-05" version="1">MLCAVTVYAQFDSPTPPRLQIPGAIPLGGPRQGGFRQGRLQATGPLPGVVNRIRRPGLARPSFKSVDAAPRPSLQSLEETAKPVTEEPEDEVDINTPTAFVSNAFSTAEPQNDYFDITTTSQPKPPIVYNPTPFTQTTPTAPRQEPVRPTQYRPLVSPQSFAPQRNEAPRPQPARLQPLSSRPQRPAFRPEPKPFVDEEEVQIQPVRQYNRQEQVNRAPVKSIPQQKYSPSNSREKKPVAQIIRKFREENDDGSITWGFENDDGSFKEETIGYDCVTRGKYGYVDPDGVKREYNYETGIPCDKANEEKEQKGFIDYQENKAVLPNGITIDLAAMGKKSKRPFRSPSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTI8</accession>
    <name>A0A194QTI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Photoreceptor outer segment membrane glycoprotein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTI8"/>
    <dbReference type="FunCoup" id="A0A194QTI8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTI8"/>
    <dbReference type="KEGG" id="pmac:106719413"/>
    <dbReference type="InParanoid" id="A0A194QTI8"/>
    <dbReference type="OrthoDB" id="9836210at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="37880" checksum="104CA76A4889848B" modified="2016-10-05" version="1">MAWGAFSFSREGRARLAAVLRALLIVQLVISLLVVLLCYNASFRVMSLLKQVHRLTVYLFYGLIVVHAYCMKLQYTSGLRLISWLLKCPHWPRAALAARTWLISGTLVAFNGLLVYAACRGTLKALMKELSSSLRIGIAQYLTEPTWKHLMDTMQIELSCCGVERPNDWHEIPWINLDFLNEDSLVVMKLAGTDGKILPPVSPYSCCTPRVLAACYHDPLQQVEWRGAWAAGSPLPSASLHTRGCAEAIRAPLARALLGLQVFNVLVLLLQFIIVILAQLLRTSAIEAVLSGDFDGPGRGWLLGTLGPTERASLITKAEAYVSARAEISYRRVPRTYAHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTN3</accession>
    <name>A0A194QTN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endothelin-converting enzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTN3"/>
    <dbReference type="STRING" id="76193.A0A194QTN3"/>
    <dbReference type="InParanoid" id="A0A194QTN3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF238">
        <property type="entry name" value="FI07649P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="331" mass="38159" checksum="1B135489D1C67858" modified="2016-10-05" version="1">MGMALGSMFVRKYFDEMSKNDTLTMTREIQQSFREILNMTDWIDSGTKKLAGHKVDSMMLRIGYPDFILNTKELNERYQEVKIHPDKYFENILNILQHLTKMEQSRIGQPVNKSLWNTAPAVVNAYYSRNKNQIMFPAGILQPPFYHRHFPRSLNYGGIGVVIGHEITHGFDDKGRLFDCEGNLHRWWSDPAIEAFHRRAQCLIDQYGRYVVPEVNMKLDGVNTQGENIADNGGVKQAFHAYLKWLKKHGSEDETLPGLNHTHTQLFFLNFAQVWCGAMRPEAMRNKLKTAVHSPGRFRVIGTLSNSQDFAKEFHCPPGSPMNPKHKCSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTV6</accession>
    <name>A0A194QTV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTV6"/>
    <dbReference type="FunCoup" id="A0A194QTV6">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QTV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF98">
        <property type="entry name" value="TORN AND DIMINISHED RHABDOMERES, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="707" mass="76535" checksum="4C7E874BFF029414" modified="2016-10-05" version="1">MSEAGEKRSGVTRVLGALGGSEACGARWTLAALLLAPLAAANSSYCAVPAVMLLAVFATFATLTCKDLRKLAEILPPPKTARGRRERNMRSFADFMSMWMCFLSHLVAVAVCARILSATADLVTGGRTRRWLFGYETRALGEPWPDVIGVTVVMVVCAMFMCGLEESMMFTFMLLMLLYLFSQCFAIFGLINLDIASIKIPLPITIYELFAAGAPISYAFSVGLPPMQNNVLKKNLFLLIGLPTIILSSLCFLYTNMLKGNSIDAVLPVTTLLEARSAGWVCPVLAGITVAGVCLALTELCPLLFSLLVLLASPEWKVLTWSMTYESTTTGSPVLAVFTAGSLAAILAFACPLSHMITLMNASHLFGITIQAFHFMIMRCVPTKEQMEAGNIEYKRLGTEGSSRVVKSASVKSKRGLWFIPSAIRHTKTLESIKSKVTKETEERECLLLDEYAGCPTEDLEQSSSGNNGRIPMAVEEDIDCPSDMEASEPDISSGDDSTDIDAVVKEYKDTIQVVTAIPEASSPPPPCVQGARWAAAGAAVQVLANAFLAVAFCNEALRLPMFLTGIPMWLCGTSICIWQPSHKLGTKKIQGLEGPVTMTMALLFLTPLLLDSWPAIILFAGAGVVIYARCERWCGDLAVRQARSTLERRKRPLTGTLAHIDTVYIASLDNLIEAGEDELDPDAECQEPAIVIITPCDGRQATTSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU94</accession>
    <name>A0A194QU94_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in calcium binding and microtubule stabilization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU94"/>
    <dbReference type="FunCoup" id="A0A194QU94">
        <property type="interactions" value="1290"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU94"/>
    <dbReference type="InParanoid" id="A0A194QU94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="18363" checksum="89D03736B47D5856" modified="2016-10-05" version="1">MFSDTYKIKLVDEVIYEVTGRLVTRSQGDIKLEGFNPSAEEADEGTDSAVESGVDIVLNHRLVETYAFGDKKSYTLYLKDYMKKLVAKLEEKSPDQVDVFKTNMNKVMKDILGRFKELQFFTGESMDCDGMVAMMEYRDIDGVSTPIMMFFKHGLEEEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUF9</accession>
    <name>A0A194QUF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Poliovirus receptor-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUF9"/>
    <dbReference type="STRING" id="76193.A0A194QUF9"/>
    <dbReference type="InParanoid" id="A0A194QUF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="261"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="840" mass="92608" checksum="8FC189BEFB39851E" modified="2016-10-05" version="1">MFCRTSLRHPIPVNSIGATFAKQGGAGYTRSGPVGIYRGKYEWANEHSALGGDCSLWVRAATLQLDDGQWQCQVTASNYDVQPVGIYRGKYEWANEHSALGGDCSLWVRAATLQLDDGQWQCQVTASNYDVQDALSSPPAALAVRVPPQSPRILFNGSHVLPGQNITVPAGSRATVVCEARYGNPPAYIEWYLEKDRLTAWSQTNASEVERPRVWAARSVLEMGATRSAHGKQLACRAHHPSYPAPYYRDSYTMLDVTFVPVVSILGADASGLSSLEEGSSALSLDCKADGNPKPYVWWTKDGQIIATNGPKLILAPVIRNHSEDGYLISSTPQLQLYNVSYNQHGQYVCVAKNFIGLEERSQQSSPVTLNILGPPVGPDAVSAHGWSGGEARAQASVCAEPPPRSAAWLWGSLRLNVPSHMGRYRALEAESIDGCYRYTLAISSVSASDARVYVLHVENERGVSSHAVSLTVHETAHVAPLIAAALVIAALLVLLLCLIVRCRRKRGSVEYKTDELNSDVKVLPADAVYTPQSHASVRGSIAGVVPAPGASMAPPPGAGEREGPRYSPGALQAALASLEREAKENVYAVLDPHIQYDITINKHGEPPKYLSLSKPLTHQRTHAFDPRYFANEINNNEIKLSTFKPVYRKSDRSSKGKNVNHKKSYVCKSNNDIEYSKDPCFGIVKGTESYLKNAFTQSSRYDVNKISKDIILERNSSKYNSNNETNAFEKDLFKSDPKSFRTSNHSRKSVDKTTPVKEVRKKIEISTNEQKEFNVNVNGDTTEDYKPRPGKVKEIASKFDRNTKNYAQSLNFKKERPRPLQTYGYQAYLDHVFPDAVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUU3</accession>
    <name>A0A194QUU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane channel-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QUU3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUU3"/>
    <dbReference type="InParanoid" id="A0A194QUU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="951"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1242"/>
        </location>
    </feature>
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        <location>
            <begin position="1254"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="1211"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1277"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1312"/>
            <end position="1323"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1329" mass="152264" checksum="9333DCAADAD92997" modified="2016-10-05" version="1">MFDCLYYKNIKDQKNEGSIVHQGSCDRPPSSPQPSVDRLSVTWADPGSMTSSGVNLFHIPSETPISNEVKFSPTAGEVSEDEDYSASLSAVLRQRRASVRRSRKGRSRRPSSPFLPDETRSRRRSSIFTTSSGDTAISIDEVPLVTQEQIFENIHLHKEVLGSVKQQPLGMRRKLKIVHQAKGYIKRHEGQLQERLAQSKSTRDIYARFNILIATKWQQLKREAANTSNLLIPWELRIKEIESHFGSVVASYFTFLRWLFWVNLVIGFILLVFVITPEYLTANPLQDGERKIIMEEERRNSTNLLTMWEFDGVLKYSPIFYGYYSNVERPEYRMPLAYFLTGLVVYIYSFVAILRKMAENSRMSKLSEKEDECIFSWKLFTGWDFMIGNAETAHNRIASVILGFKEALLEEAEKKKDPRNWRIISLRALVIICVIILLGLSAYVVVTVVTRSDDNSKPRSWLRENETTLVVTAISLTFPVFFDLLGLLEHNHPRKQLRLQLARIMLLNLLNLYSLIFALFSKIQGMSAELDSLQPSFNLNTSVMADSAIDINRASINGISGTCHEIIIPCLPCHLLSSSEFVPKESTIVEFTSTELTKPTTNIKNLNSQNLLKETKTIGPENLKIYEDNENNVMNDKGTIDNSILLLMEELDRLRNISSLTNDSIQFYGSTTDNFENYETTPLDTSTDSSSSSNSDGLITSEYKDDYLDRHLNNDLVSSNIDYKEKEETTTFTDSNFVNVIMSETTESTYFDWSTEKQGSDSDLHRGAELTTEDFIESTEINAFPSVIPTVTTKVYDDTNLSFTGETETTGKTNYPIYVDENNESSDNYTNNIDTTTTTEESEWKENQNRTISDFTTTSTTMISYLNSCKNISFNCSFNCNGKNITKVFFMSNCTISDIKCYVNQCEYKQTLKHGTKNQFNLTVIDKVYYENNRKMYNLTKETKKKLLKLCWETMFGQELVKLTVMDLVVGLLGTLFLDFFRALFVRYMNQFWCWDLEKKFPEYGDFKIAENILHLINNQGMIQLRRERTEERRKMFQLADTRRRTGSSAVENTPFTRWKKTLPALPLSKSIDSDDRKTSDETKEDSKNLKRGIFAKIVGLALDKKPEVEITSPSSYAVDGDNDVYETLPKEILKTKDMTVPKISDHKKKSNVEFKSTDSDIMKYKSEQGCLKVKIDKLCERTDKKAVLEKLKEDKIIEEELTSLPSKTIIKESNTKNDGRKKSFDTKQTSESSTYSRQSDSISSVIPVITISTTESDEEQLQYPKVVGEQKKDRSYTNSNPKQELSKTNRSSSDLKSLRRQSSIDSINDSKTPKEKKTEDGYKYQYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVL3</accession>
    <name>A0A194QVL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endocuticle structural glycoprotein SgAbd-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVL3"/>
    <dbReference type="STRING" id="76193.A0A194QVL3"/>
    <dbReference type="InParanoid" id="A0A194QVL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="32155" checksum="F79D728E9F38ACA0" modified="2016-10-05" version="1">MAATNMSTYDDMGMPPPTWTNDMVKIAGCPGDRRGDLFRKAMSSSGRHVAEKKMKNIFEESLPNNMHGKKWFNEQKPKVIVVSIEIKALRRPTHILFYTLRLKHKIDKHLDIFIIMTVAAIANAASLDNVYLPSNIDPASNEPSRTYLTPTQGAPPSRTFLTPTQNYAPTPSASSHQSQILKFENDMNENGYHYAYETSDGTKVEESGRVIPGAQPDEGSLQVEGSYSYVGVDGQTYSITYTADENGYHAAGDHLPTPPPIPEAILKSLELTAGSGGQYDKKKSSYDADAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVN7</accession>
    <name>A0A194QVN7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVN7"/>
    <dbReference type="FunCoup" id="A0A194QVN7">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVN7"/>
    <dbReference type="InParanoid" id="A0A194QVN7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="141"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="21237" checksum="15481DEBDA8E53E5" modified="2016-10-05" version="1">MSKLTPNPAKVLIREQVAAKIAALSTEEKKRQSKIVYDKIVNHPCYIKAKNVAIFMSTDQEVDTAPIIADIKAKGGAAFVPQYAGGIMRMLKLETGDESSMPLTRHGIQQHSKDQVRDDALDIGLDLIIAPGVAFSRSGGRVGHGGGYYDKYISKLRQNPNTAPKVVAIGFKCQVLDDVPVDSQDQKIDDVIFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVN8</accession>
    <name>A0A194QVN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Forkhead box protein F1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09030.1"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001710">
        <property type="term" value="P:mesodermal cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Fork_head_dom"/>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262">
        <property type="entry name" value="FORKHEAD BOX PROTEIN BINIOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN BINIOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="24154" checksum="51EB2D2838F3D50D" modified="2016-10-05" version="1">MAIRHSPNKRLTLSEIYAFLQQQFPFFRSSYQGWKNSVRHNLSLNECFVKLPKGLGRPGKGHYWTIDPSTEFMFEEGSFRRRPRGFRRKCQALKPQFASGSYLCGGGVAALPPSQPTSYELAGGSSSNAGGSTAIDYGACAYSHASSGGQQLTYGGEYCSYGGMAEREWPLAYSAVDPTYRPPPSSPPSRHDLPDILPNYQYAVANEHGKSFLFLIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY1</accession>
    <name>A0A194QVY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein kinase Src42A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVY1"/>
    <dbReference type="STRING" id="76193.A0A194QVY1"/>
    <dbReference type="InParanoid" id="A0A194QVY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13868" checksum="73EACA01015F388F" modified="2016-10-05" version="1">MGNCFSSTGEKDSKSKNERTNPHEEDPRTLHTPVPIPPPDPIRSTVNQGPDTSEIPPTRIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTKQEGYIPSNYVARLQSIEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWE7</accession>
    <name>A0A194QWE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM32A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWE7"/>
    <dbReference type="STRING" id="76193.A0A194QWE7"/>
    <dbReference type="KEGG" id="pmac:106716667"/>
    <dbReference type="InParanoid" id="A0A194QWE7"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="13079" checksum="670C8C2AE93D971C" modified="2016-10-05" version="1">MVEEDEYACVNRSQLKIKDNSGIKKKKKKKSSKETEKAIENEVKEQIKQQKSSNEKTKAELAFLKMQDKMKKQRIQQKAEMTHKQRVEKFNQHLDSLTEHFDIPKVSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX52</accession>
    <name>A0A194QX52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom carboxylesterase-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX52"/>
    <dbReference type="KEGG" id="pmac:106716728"/>
    <dbReference type="InParanoid" id="A0A194QX52"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264707" evidence="2">
        <location>
            <begin position="18"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="563" mass="62243" checksum="8A459B4DC6470B68" modified="2016-10-05" version="1">MLLLTLICAFALANAQAQDDPIVNTTQGRVQGSSAEDGNYYVFYGINYAGSVSGENRFKAPPPPPSYPGVFHANNSDVICSHPTSKGIVGVEDCLTLSIYTANLTASQPVLVWLQGEEYTTTDTTLRSFKNFVDRNVVVVNVNYRLSIFGFLCLGVPEAPGNAGLKDVVQALKWIQENIAGFGGNPNNVVLFGHGSGAAMVDLLTLSPSAENLMHKAITQSGSALSPGAIAYKPIEYAEALGAKLGYTGKSREELARMLTTTDITLLATALTEFEFFNNTALFAPCIENNVDSNNTIINDAPINIIRSGNYSHIPYMAGYTNKEGTIRAHEAAYSQWLEKMQTNFDDFIQVDLDVATNSNKTAIVESIREFYFSQRIINMKTIEDYLDYHGDTMILVSAIRGVRERALTSRAVVYLYEFAYTGALNSDWPLPQIPLTGVRHGGLLKYLLNINLTQIEGFMRETVMKHYLSFIYNGTQAIPYDSLWDPISSSRFPYLIIEGGEYAPNLSMSRIQQRYNPHERTMSFWNDNYATLYVAPSPVSSAAQLMSFFLLVGLFQLLLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX72</accession>
    <name>A0A194QX72_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX72"/>
    <dbReference type="InParanoid" id="A0A194QX72"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF40">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="38443" checksum="D8A6ECDE9634EB6A" modified="2016-10-05" version="1">MWLPDNRTLTLKARVKPIRENWNLKYSATYVLCLLRETGVKPQETVGASLSVLASTAQHRPPTNQLIVLDTNPRKGIEETLHVCVKPFHFSYARADWLLEWFELNRLLGVSHFYMYNESLSAPVACLIEHYRKQGLVTLLPWKLPIVSKVEIRTEGQFAAFNDCLYRSMSAAGWLLVIDVDEVVLPRRERTLSALLTALRAAYNPPSKAPSAFLFRNAFFYLGWEDDAEAPAPLLTSRKTRRWAAPHAVKNRSKYALRPRDAVELGNHFVWELAPGASSVGVPTDRALLHHYRMACEYGGQQCLTVPSTVDRTAHRWADDLLKRVNAEKDVYLKTCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYB3</accession>
    <name>A0A194QYB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Selenide, water dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYB3"/>
    <dbReference type="FunCoup" id="A0A194QYB3">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYB3"/>
    <dbReference type="KEGG" id="pmac:106715770"/>
    <dbReference type="InParanoid" id="A0A194QYB3"/>
    <dbReference type="OMA" id="LARDWMC"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000006">
        <property type="entry name" value="Selenide water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000010">
        <property type="entry name" value="Selenide, water dikinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="220"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="402" mass="44092" checksum="32489AC68EE22C45" modified="2016-10-05" version="1">MSYSSSVAQDTLAAAQLEMAGNPNALALRRPFDPVAHDLEASFRLTRFADLKGRSCKVPQDVLGKLVESLQQDYSQQEQDQFMHVAIPRIGIGLDCSVTPLRHGGLCLVQTTDFFYPLVDDPYMMGKIACANVLSDLYAMGVTECDNMLMLLGVSTKMTEKERDVVIPLIMRGFKDSALEAGTSVTGGQTVINPWCTIGGAATTICQPNEYIVPDNAVMGDVLVLTKPLGTQVAVNAHQWLDQPERWNRIKLVVSEEDVRKAYHRAMDSMSRLNRIAARLMHKYNAHGSTDVTGFGLLGHAQNLASHQKNEVSFVIHNLPVIAKMAAVAKACGNMFQLLQGHAPETSGGLLICLPREQAAAYCKDIEKQEGYQAWIIGIVEKGNRTARIIDKPRVIEVPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0I1</accession>
    <name>A0A194R0I1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0I1"/>
    <dbReference type="FunCoup" id="A0A194R0I1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0I1"/>
    <dbReference type="KEGG" id="pmac:106715050"/>
    <dbReference type="InParanoid" id="A0A194R0I1"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF30">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="44131" checksum="660A6821CF6D3AAF" modified="2016-10-05" version="1">MLFSVKRVRAKVKSKAFYCLRCSAKTAAFLFWATLYMIVMRLTVFKSGESKQAKDWSIIPDNYTKWLMQGPVLGDDSPAETANNLLEPDNVTISELETRAARVQDVCRSRSLDSQTINNKEFFVDHAHNLVWCNIFKAASSSWLYNFNILGGYDKKFLARTQQTPLTLARKKFPRPSEEELRDTITTPGVISLLVVREPFVRLLSAYRDKLEYISPPFYRKLAKGIVAEQREKAVKVLGPIKSIGPTFYEFVAYLIAKHKAEGPNMVYDEHWAPYYQFCSPCAVNFTVIAKVETLSRDSSYVIQQLGLGQVLDRRASNRRTRLRIIMNKSRDGKNTSALLRHYFGQLDDNMLNDLLRIYGIDFEMFGYETNLYKRYVRHKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R137</accession>
    <name>A0A194R137_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R137"/>
    <dbReference type="FunCoup" id="A0A194R137">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R137"/>
    <dbReference type="KEGG" id="pmac:106716577"/>
    <dbReference type="InParanoid" id="A0A194R137"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="52378" checksum="254331CBD952FD3F" modified="2016-10-05" version="1">MPLQIRRNCLLFLRENLLTLLTVIGVVSGTLLGWGLRASGHEWSRRDVMYFQYPGELFLRMLKSLIVPLLVSSIVSAIGSLDLSLSGKVGLRAIIYYMTTTVCAVMLGIALVTTIKPGKDPEAYSQPNTTKVVTKDTLTSDTLLDLIRNVFPENIAQATIASYRTRLSYDPKDSKMVKGHIETYKIEGDYQSGTNVLGLVCFSIVLGITMGKMGDKSKPLQEFFHTLSEAMMIITGWVIWLSLLGVFFLVTAKIMEIDSFADLVGRLGLYFMTVLLGLFLHGFGTLSVLFILATKKLPCRYIAKMGQVMATAFGTASSSATMPITIGCCDDMGLDPRITRFVIPIGATINMDGTALYEAVAAIFIAQLRRVEMSFGKIVAVSVTATAASIGAAGIPQAGLVTMVMVLDTVNLPAEDVSIILAVDWLLDRFRTTINVVCDALGAIIVTTLSQGDIEKSRAIHQNDRELAPAHELTELEKGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1X2</accession>
    <name>A0A194R1X2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-splicing factor ISY1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1X2"/>
    <dbReference type="FunCoup" id="A0A194R1X2">
        <property type="interactions" value="1745"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1X2"/>
    <dbReference type="InParanoid" id="A0A194R1X2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="219" mass="25608" checksum="D56393CB552A9F53" modified="2016-10-05" version="1">MYVYRLNLHIFFLPAGLGEFRIRDLNDEINKLMREKRHWEVQIKSLGGPDHARVGPRMLDQDGKEVPGNRGYKYFGAAKDLPGVRELFEQEPPPPARRTRADLMRDVDADYYGYRDDDDGLLLPLEKDAERHAIARAVEEWKRNKEQNKEQDLPEEENIYPEDPDDKRIEDDEEMTEKSSAPTLIAVPSQKDVEEALLRRKKQELLERYGCLDVKLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R293</accession>
    <name>A0A194R293_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R293"/>
    <dbReference type="STRING" id="76193.A0A194R293"/>
    <dbReference type="InParanoid" id="A0A194R293"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="424" mass="47493" checksum="41B9944211F73E88" modified="2016-10-05" version="1">MTKLDKGLTGFRKLVRLNLCGNFLREVDAGFLPRGLRTLEMQSNFIQTLEVLATGLPSGLLYLGLAKNVIDCVEGISKLPDSITVLDLSDNDICDLETTLNSMSALPNLVSLQLAGNPCAVCAGYARCTLSKLPRLQWLDLREVLPTDRPDENLEIHPDDLRSTYFNFTIFRIISAPQPPKGDKGAIMTFHVELELPLLDATRRNFLMFRNNDSLVEMLPPPEDDLWEPSKIGSMVKSKSVLEGEASSRGSHIFHLTAVDSREIRHYTTFESNRVPWNKIMNFQEPAVRIFCPNLIGLRDTFRTVVTLRLVYTVSIPVKQGKGDKKSAHTMKAGPQEQRATIATIRCALNRPDWTQVSQDYHWDDTLDDDAIYYGDGDLSTLQYSQATAKVVKGKTDTDQGSARQQLPENLTCHFGFGIDTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2K3</accession>
    <name>A0A194R2K3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect defense protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2K3"/>
    <dbReference type="FunCoup" id="A0A194R2K3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2K3"/>
    <dbReference type="InParanoid" id="A0A194R2K3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4060:FF:000003">
        <property type="entry name" value="Ferric chelate reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="12">
        <location>
            <begin position="107"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="241" mass="26289" checksum="517DFE35CF358D96" modified="2016-10-05" version="1">METRGKASLCPNLKNNTTNDSGQRKPGLRPSLNLILVDQRTSIKIFKLLGCSWWSSAFLRRCVPDGAIVGRVQRATSLQPFMYRLFPNLCIEQRLILNRNKMTLFTYIAVAVAVLAYADGYSVGAPESACKDMIPRHPVPAQKTAAPYKITTSTKVVRAGTPMEVTISGNKPSDTMRGILLQARKGDDIVGTFTLDPNDSFAQLLNCGAPGNALIKFRATIAYNGAVFWVGVESAPVTITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3S5</accession>
    <name>A0A194R3S5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein N-terminal asparagine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3S5"/>
    <dbReference type="FunCoup" id="A0A194R3S5">
        <property type="interactions" value="1343"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3S5"/>
    <dbReference type="InParanoid" id="A0A194R3S5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="339" mass="36347" checksum="026CDD3EE69C6972" modified="2016-10-05" version="1">MPWESNIQARKDIESVVSLFAIHGASMVVVLNGVLADECPTSVRALLAAHPGYRDAAAQLLAAAPRVVGPQGLLYVAQRELAAAVPHDKNVSIIGSDDATSCIIVVVRHSGSGAVALAHLDGSGTGEAAAALVARALHLAAGYPEGRLELQLVGGFTDPHRYSDELFANIMLSFHRLSEEIDLTMACCCELNTALGGGAGSPLVTGVGVDVRAGDLFPATFPDKGPEMPLRAARTITGGPNSAQVLDIYDNGVGMLRIGPFNYDPLRGVDLWLEQTDDFILKHLSTTPNAEPPHFVHHIRVTLKFIQTHPFPAVTVFPDNRPHFYRRDEQTGLWAPMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4T9</accession>
    <name>A0A194R4T9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine triad nucleotide-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4T9"/>
    <dbReference type="FunCoup" id="A0A194R4T9">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4T9"/>
    <dbReference type="KEGG" id="pmac:106715254"/>
    <dbReference type="InParanoid" id="A0A194R4T9"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="13880" checksum="31307CE83F5004BF" modified="2016-10-05" version="1">MASEVELAQSALPGGDTIFGKILRKEIPAKFVYEDDQCVAFHDVNPQAPTHILVIPRKPIPQLSKASDEDEQLLGHLMIAARKIAAQEGLGDSGFRIVINDGKNGAQSVYHLHLHILGGRQLRWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4W4</accession>
    <name>A0A194R4W4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4W4"/>
    <dbReference type="STRING" id="76193.A0A194R4W4"/>
    <dbReference type="KEGG" id="pmac:106713499"/>
    <dbReference type="InParanoid" id="A0A194R4W4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="38924" checksum="3A12B6940D713F83" modified="2016-10-05" version="1">MENDAIENETIDKVKSEIAPTETDNVEQPENVDQPENVEQPDNVEQLENVEHTENVDQQENVDQQENVDQQENVDQPENIDQQENVDQTENVLQDEPTDETQAIVGEENRQEKKEEKVEVTEDIVEEEEQFVEEPPPDPAAPYNLTDSTEALKPPFALRHDQLAEVEQLWDIYQDYNPAYTDIDNYITEKELIYMLKALLLMTYTPEQLQELIEFCVRPPHPDGHITFEQFVKIVTIRQRAIPIEEELRLALQSLDPNKTGMIDREFFKELLLKQGHKLPPKILENLIKEVDLSNDGTIGIEDVVGTLGIDLNRDDIAMLRAAVFPDENPPKEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5M9</accession>
    <name>A0A194R5M9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5M9"/>
    <dbReference type="STRING" id="76193.A0A194R5M9"/>
    <dbReference type="KEGG" id="pmac:106713201"/>
    <dbReference type="InParanoid" id="A0A194R5M9"/>
    <dbReference type="OrthoDB" id="6081971at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="236" mass="27591" checksum="63DA92638B3CFB04" modified="2016-10-05" version="1">MELETIKKFINLIRSYPEIYAVGQSDYKNMYKKEIAWKKIKEKIGMDAKKLKIKWRNLRDTYIKHKNCRRSGIKGPNTLYNWVWANEMAFVEPYIKLRPKNIAHNNSINCTDSDVNVISDEENEQKETQNVESSEPETEEIDRGPVKRRRHESDEDTVDIVSNITTERNTQEAVVNVPCDRTDMEFLGYANTVKKLSLRSQALIKFQITKILTRYQIQELSSKKYTLSNASCNEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8C4</accession>
    <name>A0A194R8C4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8C4"/>
    <dbReference type="FunCoup" id="A0A194R8C4">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8C4"/>
    <dbReference type="KEGG" id="pmac:106712551"/>
    <dbReference type="InParanoid" id="A0A194R8C4"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265002" evidence="2">
        <location>
            <begin position="18"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="130"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="474"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="775" mass="89466" checksum="19082F8111F9215A" modified="2016-10-05" version="1">MKLQALLVYLKICCIAAINLDYLDPTVLQTKTSPQVQQDAATTIINKYTSQVSVTIDPLLFNNKKDVCALRTSDGRLQIKASTGVAALWGFNYYLKKYCKSQIAWQTQRVTIPDTLPEVNEVIVASDRFRYYQNVCTASYSFVWWTPDQWINHVEWMALNGINLALAPIAQEAAWDRIYRKLGMTDDEINEYFTGPAFLSWLRMGNIHGWGGPLTKSWHERQQNIQDSVVSYMFKLGIIPVFPAFNGHVPAAFTRLYPNVTFYSVEKWNKFSPDYCCGLFINPREPLFMQIGEMFLREMNSGLGVGDIFTADPFNEIQVQPWSTSLVRDTASAIFSAISKFNNNAVWLVQNWMFVHNPVQWPLKRVQSFLTAVPEGRMLVLDLQSEQWPQYNLYQMYYGQPFIWCMLHNFGGTLGMFGNMQAINKDVYQARDKANSTMIGIGLTPEGINQNYVMYDLMLEVAWRREPVQNLDNWVADYAERRYGCNTTSSAWRYLLKSVYNFSGLNPIRGKYVITRRPSFRIRPWAWYKSSDLLNAFKEFVLATNSGCNSDGFYYDLVDVTRQALQYRADQLYLDILNQRFSNVMAFNASIVRFIDLMNDMENILATNNNFKLVDWLTAARSVSNDNTFLYELNARNQITLWGPNGEISDYACKQWAELFHYYYTPRWSLFLSMALDAKARNEFFDESSAQKVVRSSVEEQFLTVAIEPLQCNDTKAVAFYMYEKWGFVSGLEDLPLSIVRSNPSRRTTLPDVDSAEREVDLPTVIHWHSTTPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8M5</accession>
    <name>A0A194R8M5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8M5"/>
    <dbReference type="InParanoid" id="A0A194R8M5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="352" mass="39540" checksum="274ADA2143993814" modified="2016-10-05" version="1">MDLRKCCLGNCSSTNRTHRLFYLPKDDNLRQLWLSFLIPTNIELSGLSKEQLLAKRVCQKHFDRYQFDNTGNRLRSGYPCLFTAKEIFYGSPLSSTVGDHISDHNYCLPIAPESDIKEATALRVDGDHSYHKSVESQVPEPIEIASTTKCSHVVSQILVEPAPETKEQVKPILVETTGDHSYHKSVESQVPEPIEIASTTKCSVVVEPAPETKEQVKPILVETTDTTTRQKHALKLTKKCHVNVDGTIEVSGQKLSVVFDPPHLLKGLRNNFLTKNMVFDGAIATWDDILTVYRADCQLGHTRMNKKLTDHHVIASKIKKMKVSVAAQVLSAQTSAMLKYTSLYSMYFILQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8R7</accession>
    <name>A0A194R8R7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuropeptide FF receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8R7"/>
    <dbReference type="STRING" id="76193.A0A194R8R7"/>
    <dbReference type="InParanoid" id="A0A194R8R7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="34507" checksum="5566DAA02ED80D8F" modified="2016-10-05" version="1">MADDCITRFNIYSGSWVFADEFLYKQVSPLRVKQNKRRFLAIWWPLKCQITKRRARMMIVFIWIFAISVTTPWVFFFDLVVVFEDSPHVRLCLDVWPNPLSEILYFVIGNLIFCYILPMVLITMCYILIWIKVWRRAIPTDTQDAQMERMQQKSKVKVVKMLVVVVILFVLSWFPLYLIFARIKLGGPVQKWEEDIFPVVTPLAQWLGSSNSCINPILYAFFNKKYRKGFVAIIKSRKCCGRLRYYETIALQSSSTSTRKSWHYNNNNHASITRRSPPVDKNAVSFIFNHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9D8</accession>
    <name>A0A194R9D8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9D8"/>
    <dbReference type="FunCoup" id="A0A194R9D8">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9D8"/>
    <dbReference type="InParanoid" id="A0A194R9D8"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="10">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="37425" checksum="2D5FA035B8638CBF" modified="2016-10-05" version="1">MMHITTGATPVNRYVNCERRPGRSPTSAPAPAPGAASSLVYKMSEEKKVVLVTGGSGLVGQAIKEVIEKERQDDPHSDGESWIFCGSKDADLRDKAQTEALFDKHKPTHVIHLAAMVGGLFHNMAHNLDFFRENMAINDNILHASYKYNVKKVVSCLSTCIFPDKTTYPIDETMVHNGPPHPSNFGYSYAKRMIDILNRFIIIVTSITETANEARFTVLGSGRPLRQFIYSVDLARLFVWALRHYNNVEPLILSVDEEEEVTIAEVAEAIKKAHGYEGEIVFDSSKADGQHKKTASNNKLRTLYKDFEFTPFHTAIQYTVDWFKHNREHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9L2</accession>
    <name>A0A194R9L2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pogo transposable element with KRAB domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9L2"/>
    <dbReference type="InParanoid" id="A0A194R9L2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="509" mass="57325" checksum="57BF5807865B6314" modified="2016-10-05" version="1">MPGPDFAKSFLNRHSDKISQRVSQNIKRNRAAVSPDVIKEYFTQLKISISDVPIDNIVNYDETNLADDPGRKKILTKRGTKYPERVMNHSKSAVSIMMACTAAGEMLPPYVVYKAQNLYDTWTKSGPNGSRYNRSPSGWFDSNIFEDWVTTIILPFFENKPGKKCMVGDNLSSHLSIDLIKKCQERDIHFIFLPANSTHLTQPLDVAFFRPMKIAWRNIILQWKKTDGRNQAAIPKGCFPKLLSKLMDSLSENGPANILSGFRKTGIHPFNPSEVLNKLPDWDNRHQENEAVDETVLDFLKEMRYGTGGIVEPKKKKKLLVQAGKSVLCSSDDSYIENNPEYLPTSVPKERNTSQTDKKITIGKGKGKGKKSKTDDKSQKNNPPENRDDQVIASSSYVNTPTIQPANSPDEVASCLYNNNPFEIMPVIFEEDLDGIELSETVPNNDEAGNRIQEKATKIEIISNKVLSNEELKKILSNKPVTSTEINGSSRPSYYKNDSDILKDLMDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9N8</accession>
    <name>A0A194R9N8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET and MYND domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9N8"/>
    <dbReference type="STRING" id="76193.A0A194R9N8"/>
    <dbReference type="InParanoid" id="A0A194R9N8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="29344" checksum="BFB622CA9777362D" modified="2016-10-05" version="1" fragment="single">LLKTPYERQTELLENYYFLCECDRCFGDIQIKILHAAKCPNQKCDNPVKISWKDCDLVRKPKDESKKNGYIKENGDSNNESEKEESECNNKSEIEREGECSACGTKCTDKQIEVFKKAMEFTEMHLQKMKNVDVCKFCLEKQEGILHPLNVMHAQTLDHAFDALIQVQLWETACLYAEKLIPCFKFYYGERHPLLGLLHLKYGKILLYKMDLSKALEQLKLAEKILKITHGDRHPLYKEQLLTLLSQAMLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9S8</accession>
    <name>A0A194R9S8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circadian clock-controlled protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9S8"/>
    <dbReference type="STRING" id="76193.A0A194R9S8"/>
    <dbReference type="KEGG" id="pmac:106711449"/>
    <dbReference type="InParanoid" id="A0A194R9S8"/>
    <dbReference type="OrthoDB" id="6853364at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265029" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="25717" checksum="E7DBD9179C340864" modified="2016-10-05" version="1">MREISLILTVFFAVFCSIEAVPFIQKCKTDDSKCVKASSVAAIPIFAAGIPEYGVKTLDPITFPKIDASSPNLKLILTDVTFKGLKDCQAKKIKIEKSKGKLLIKLLCSVDMDGSYEMNGKLLILPIEGKGPIHVKLRKAEVNVEVDVDFQSTKWNIKEWKHSYELKDNSEVVFENLFNGNEVLASAARDVIANSGNEIITEVGPPVIKTVVDEVIKSIKAFFDAVPASELALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC83</accession>
    <name>A0A194RC83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylcytosine dioxygenase TET1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC83"/>
    <dbReference type="STRING" id="76193.A0A194RC83"/>
    <dbReference type="InParanoid" id="A0A194RC83"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040388">
        <property type="entry name" value="CXXC4/CXXC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13419:SF0">
        <property type="entry name" value="CXXC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13419">
        <property type="entry name" value="ZINC FINGER-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="9">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="482" mass="52876" checksum="6564B3358FA8D184" modified="2016-10-05" version="1">MSEALRSEAGADSAHLPPFSTFGDMADNEQRILTADGRLLDPAWEYYERTGDTVSVIASQPQYRPWESMPITVNSKDAILRAGFSSPLDYQSVTLQPIPNKLPSFQSQFQTFPETTVIPETGLPSVTPVPVTASPTPSASPSQLTQLTQLTTPSSPAHLTTLAQVTPLSTTLTTLSPVNATTFHTLTAVNARSYPIVPAPLQARELAPAGQTYIDDRHIQLYQPNIATINAFPTQNGILHQNGTLLHQNGSLIQNIQSPTVVHVLKNEPFDMKSLQDKYTPNGLHHSNFQNPMLMDNGYDKKSNGFGSASSPTRSDFRKKERRKMRANSSESDGSNMEVGSESSGQVAAVSSTAGFKSPMHGAPPMNTGPMELDDISSEKQYFPSQTKKKRKRCGECIGCQRKDNCGDCAPCRNDKSHQICKQRRCEKLTEKKFIRDFPTDTPGLSTSIPPRVTPRHTTPLPTPRTSERSNSARVGIPTYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCQ5</accession>
    <name>A0A194RCQ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCQ5"/>
    <dbReference type="FunCoup" id="A0A194RCQ5">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCQ5"/>
    <dbReference type="KEGG" id="pmac:106710627"/>
    <dbReference type="InParanoid" id="A0A194RCQ5"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="29249" checksum="65FFAB8A46964B1B" modified="2016-10-05" version="1">MGVICMRNLVRSKEILLRSMSIDIGGMRIKYKDKDDTFLEKHLVAKEPFGQFKAWFDEACSRKEILEPNAMCLATVSKDGYPSARFVLCKGYGKDGFKFFTNYGSRKAKEMSENPNVAATFYWEVLNRSVRIEGYVEKLSEEESTKYFHSRPVPSQIAACASYQSTPIESRDILCERERKLEAEYMIPEKEIPKPSYWGGYIIRPRAVEFWQGQRDRLHDRIKFRKPTEGEGVDGKLLHQGEDGWVYQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCQ6</accession>
    <name>A0A194RCQ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neural cell adhesion molecule 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCQ6"/>
    <dbReference type="InParanoid" id="A0A194RCQ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265087" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="358"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="456"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116733" checksum="F87968BBA82D80CE" modified="2016-10-05" version="1">MRRIDLLLVAVVLLKSLNAQEEIITVEAVVGQSTELPCNVTAENEGDVLRIIAWYRDGSPTAFYSSRDLRGNNSDVLSPGGRYKLITSEDETEERLQILAVRPSDAGQYYCFADFESSRSHKTYITLEVIEPPLRLWVIHENGTRVTTASAGANTSRNLGPYYIGDTVHLFCVVFGGKPLSSLSWWAGSRLLKNTTTPLSEQRVRGDLLYGPLRREDHGRLLTCLANNNDRTPPLSIDITIDMYLPPELVMMRVSGEKGEVVSSGRVRAGRPLRAQCRVLGARPSPPVIWCLNSSQIHNIDQNITREPSQRLLVSEVELVVSAQHDEALLTCCAPDSARTASRLICAQPLPLTVLYPPQLKIVVEGELENNTLTAVKGTNLTINCSYEANPSVYEITWFHGNDLVNQKYDQDESSMKQTLELREISESDSGEYVCAATNNEGSAYSNPIVIDVTYPAYCEDETIAEYGVAEDDSINITCSVKSNPAPSAYRWAFISETMDANKRRNNQTYNDETEMYDQDESSMKPTLELREISESDSGEYVCAATNNEGSAYSNPIVIDVTYPAYCEDETIAEYGVAEDDSINITCSVKSNPAPSVYRWAFISETMDANKRRNNQTYNDETEVPTLKYTRPNDTSYTLIRCWGLNNVVGKGLPQTKCSFLITDETAPRPPSACRAVKNENDITVTCDKGHDGGLQQKFKFNVFSSDSEEQTLSIINQEPKFIIPEPKVESYKFVVVAFNAKGESSTVEIDKDSIIDETEGEVGPVSSVSNITALALALCGGVLLLALAACGLVLCAHERGARHDLPRAHSDPPLCAYSTEDTNCETYHDSDEGSECNVRRTESFRRAISRYPSKNYDVRRTGSFHSARYLHELGEAGGLAGGQAGGRAGEGLRHSASCRMHSMQNVSRKRDMDALCDHLVMHLPPETNYNVAKPMNTFYTMPRKMRHKQAKELSDETSEITQTSDGFSLPPPPDEFGTYRAATKIKDMPNKSTPTYTTIVRKSPSGKELGKQQTISPNTIGLPTLSGAQNSLYTYPDYDSQGNTINTNPFDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REC9</accession>
    <name>A0A194REC9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 15">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_09747</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 15"/>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REC9"/>
    <dbReference type="FunCoup" id="A0A194REC9">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REC9"/>
    <dbReference type="InParanoid" id="A0A194REC9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF35">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="16">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="33219" checksum="ABC89BDB029CB5F9" modified="2016-10-05" version="1">MVVPSPFVYWAQTDKLITLKIDLKNVVKPDVDIIDNKIKFFGKGIGAHGDTQYGFSLDLFSSLKSDDDQGPTIRLFENRVELILKKEKDAWWPRLTAQPQKPAWLKINFDLWKSEDGIDSDEEARDVMKDYPGMYDQLHKEEMGYRKEAEPRMQTKPVVFYLFLIWGLIEVVRYPFYITQIYKKEIYILTWLRYTLWIPLYPLGILCESIVILRNIPYFEETQKFSVSMPNEWNFAFHLPSIMRVYLLVLTFPGMFFVMSHMHKLRTVKLKPKIIIKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REZ5</accession>
    <name>A0A194REZ5_PAPMA</name>
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        <submittedName>
            <fullName evidence="4">Protein SCAF8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="splicing factor, arginine/serine-rich 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="323" mass="35855" checksum="6FC9F62D47F7511F" modified="2016-10-05" version="1">MDMPEVKAFNAELSGLYENKPPISKAKMSAITKGAIKAIKFYKHVVHSVEKFIQKCKAEYKVPGLYVIDSIVRQSRHQFGQDKDVFAPRFAKNMQQTFANLFRCPPEDKRNIIRVLNLWQKNNVFGPDVIQPLMDMADPNHPLHQEILQQQNNTTNGSSLNISHNTTSLGEGKMSPTAQNTPRAATPPPPPDQCNVHEHEQRAASDVVSVLRSQEQAAPGVKFNRKLLNDFEYESEDEAAGAEPHPAHPPHPAHPAHPAHAHHGPHSNAHNPTDALGSILTNPEIMRQLQSLQAQMQMMTGLQVPVSVSRTVTCPPASLLLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGW0</accession>
    <name>A0A194RGW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGW0"/>
    <dbReference type="FunCoup" id="A0A194RGW0">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGW0"/>
    <dbReference type="KEGG" id="pmac:106709011"/>
    <dbReference type="InParanoid" id="A0A194RGW0"/>
    <dbReference type="OrthoDB" id="6337960at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038832">
        <property type="entry name" value="CDCA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="412" mass="45977" checksum="12A47C9353E6ADD7" modified="2016-10-05" version="1">MGSNTSKSISETAVHEQKNDLDIDTNPDPRSPTPEITRTPLQNKNNSKHNITKNVDLRKTFENGQVDEKLIHNNPILTAVIKNHLQSYDPRSPTQDFERTPIVLPTIDENGIKKKTSRLQNNNSYASPCLKKDPNDDFETSDSTINLSPDLVVAKNLCDGFYDLSLNETLDENEEPVGSSTTSNKCIEDKLSPDRTDQPKVLLETNFDYVDLKNDDIEDSKLSYTNGEIEEFKILKNDPRSPSVDIKRTPIVVTMTEGNDSQDNVEEMSDDTLIKVLQSTSEQTHVGANNVDGVLIYEDESAVITTPKKTRPIHSLGSRTPLSCMKNTTDASHTRSKSANNLEKKKELTKTASHLKYVSHIPRLKSLSKQITSGSLVSLKNTSKSSSVSGDCENTPPHSHRDRWDKDNSMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHI3</accession>
    <name>A0A194RHI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_13755</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ16899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHI3"/>
    <dbReference type="FunCoup" id="A0A194RHI3">
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHI3"/>
    <dbReference type="KEGG" id="pmac:106708900"/>
    <dbReference type="InParanoid" id="A0A194RHI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="144"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="799"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
    <sequence length="1027" mass="118970" checksum="39187C0318253939" modified="2016-10-05" version="1">MSNTEEAMEAAEAGENSNGSSSDTTSSRGKEGDFESKIETDRSKRFDFLLKQTEIFSHFMSNTPKSGSSPPKAKAGRPKKNKDPELPGSAGDHRHRKTEQEEDEELLAETNTKTKTIFRFEASPPYIKNGEMRDYQVRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYMKHFRNVPGPHIVIVPKSTLTNWMNEFKKWCPSLRAVCLIGDQETRNTFIRETLMPGNWDVCITSYEMIIREKSVFKKFNWRYMVIDEAHRIKNEKSKLSELLREFKSMNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSDDFDSWFNTNAALGDNQLVSRLHAVLRPFLLRRLKSEVEKKLKPKKEVKVYVGLSKMQREWYTKVLMKDIDVVNGAGKVEKMRLQNILMQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNCGKLVILDKLLPKLREQGSRVLIFSQMTRMLDILEDYCHWRQYKYCRLDGQTPHEDRNRQIEEYNAEGSEKFVFMLSTRAGGLGINLTSADVVIIYDSDWNPQMDLQAMDRAHRIGQMKQVRVFRLITDNTVEEKIVERAEVKLRLDKLVIQSGRLVDTKNQLNKDEMLNMIRHGANHVFSSKDSEITDEDIDTILAKGESKTEELKQKLESLGESSLRAFSMDTPGATTDSVYQFEGEDYREKQKIIPVGSWIEPPKRERKANYAVDAYFREALRVSEPKAPKVQAPRPPKQPIVQDFQFFPSRLFELLDQEIYHYRKTLGYKVPRNPELGPDAAKIQREEQRKIDEAEALTEEEIQEKEQLLTQGFTNWTKRDFNQFIKANEKYGRDDIENIAKDVEGKTPEEVMEYSAVFWERCHELQDIDRIMGQIERGEAKIQRRASIKKALDAKMARYRAPFHQLRISYGTNKGKNYVEEEDRFLVCMLHKLGFDKENVYEELRAAVHAAPQFRFDWFLKSRTAVELQRRCNTLITLIERENQELEEKERAEKKKKTGTTNQNTPGGNTTGKGSNASKRKAESTPDASQKNKKKKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHL6</accession>
    <name>A0A194RHL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pmac:106708930"/>
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    <dbReference type="OrthoDB" id="7490542at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265224" evidence="2">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="399" mass="42817" checksum="D71E9CE35A2146F7" modified="2016-10-05" version="1">MRRVGNSMLVTVIVLSAACGLVQSSGVSLAGPAPPAPVVTAASSQYFERTFNRLVAAPPAIQPVYPVASPPQVIPVARATQFIPVAPAPPVVPVAPAPVIPVAPVPNVFRVAPVPGVFPLQPPRPVFVQPTTKDKPEPMAPTNPPQSAPTDPNVAIAIATANAAAPVATFLLPPYPFGPPPSFGFIPSSPAFVPDEDREKEKTTETTSQTEGTTTEKENETTTPVPTNIDNNFVQALPSNNNVNFREYLPPPFQLPLTPDAPQRQPQLPPLSRPTQLQPRPTYLPPLARPQAGRPQKVKTSVEVVPVPLTYIAPPPLKKHHPVKLIKVTKHIHTFIPAGKIIIRPVSHTIRSVGNAVYAKAYGAPITAKKVAFYRKTISRRSKTRDIEPTTLRPLRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ20</accession>
    <name>A0A194RJ20_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ20"/>
    <dbReference type="KEGG" id="pmac:106708319"/>
    <dbReference type="InParanoid" id="A0A194RJ20"/>
    <dbReference type="OrthoDB" id="8188574at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265238" evidence="2">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="23792" checksum="9E0735E251AB1116" modified="2016-10-05" version="1">MAVKIIYLLFLFSFGQCSVIVPEELPSLLSVAYSNIPPIKKGTDSRVGFGFAFGNHADFQVMFELGPQTNTMNLTGQPFGTGSNKRQAPALPPPKLNKNREKFLQTDAGKYLQSWAQKMKTPSKIVHKRPDTSRPGEVMNLEDSVVELVKNDKGEYEIHQPKPGHMPQYVLDNLKRLYGQKKEEAQKLGDQKRTEDDVRKITEDLSNVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJC9</accession>
    <name>A0A194RJC9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJC9"/>
    <dbReference type="InParanoid" id="A0A194RJC9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="78" mass="8727" checksum="9FA63E1EC27423EE" modified="2016-10-05" version="1">MGYKQYLAVGQSARNRLFGLAPRISGDKRTLPLNMMISQQGKINHGTKAHRYRGEREAWVEGAGLLDVPIYRSAGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKB8</accession>
    <name>A0A194RKB8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKB8"/>
    <dbReference type="FunCoup" id="A0A194RKB8">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKB8"/>
    <dbReference type="KEGG" id="pmac:106707817"/>
    <dbReference type="InParanoid" id="A0A194RKB8"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="154"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="526"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="601"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="794" mass="90473" checksum="5C0BBA5300BCD0DD" modified="2016-10-05" version="1">MNLAKSLFSSRDHVGYVGREDHERKISASLADDDPEDVIDAIRGLNLADELLPAPGGPFSSLTQSMVPQDIMAKLAQPESEGQGGLPDYRFDEFGFCVDDEEGSEVSDKLMSNVVQEEDHHRLQWEFYSKEISFSESEGKFSKSEKLQQMVKDGVPHMLRPQVWMHLCGANKKRATTEITYHEIVRASSDDGLVTSKQIEKDLVQILPNNVCFSHPTSTGVPRLRRILRALAWLYPDIGYCQGTGMIAASLLLLMEEEEAFWIMCTTVEDLLPASYYSSTLIGIQADQKVLRSLISTYLPGIDQVLNAHDIELSLITMHWFLTLYANVVHMKILLRIWDLFFFEGSIVLFKVTLAMLKIKENRFTEISNSAQIFNALSDIPGEIDDVNLLVKTIDEVCGDTLSPALIETHRRRHLAYLMADQGALVGNPGAVPNLPKQHLQRRQIKRSKSVIQTILFGDDSNNEDAVSKNVKQTEILVDLREAILQVARHFLTLEPQLQSEVQLTADYTMQSHAADRERYVNVSRSKRRRAKALLDFERRDGDELGFRKNDVIEVISSRDEHCWIGELNGLRGWFPARFVTFLDEKGVKYSRAGDDSITEKAAHLVRGVLAPAFKRVLLHGIKKPSFLDGPCHPWLFIEEASSREVEKDFNSVYSRLVLCKTYRLDEEGKVLTPEELLYRCVQAINLSHDNAHAQMDVKLRTLICMGLNEEALHLWLEVLCSCVDVVQKWYHPWSFINSPGWVQIKCELRILSQFGFNLNPEWELPLKKDTQNQPLKEGVRDMLVKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKL1</accession>
    <name>A0A194RKL1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKL1"/>
    <dbReference type="STRING" id="76193.A0A194RKL1"/>
    <dbReference type="InParanoid" id="A0A194RKL1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265282" evidence="2">
        <location>
            <begin position="17"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="39745" checksum="E84F155071DB9E43" modified="2016-10-05" version="1">MMRRIPLLLIVTVASCMEMRETVERMVMVRTTGSDLQPAATGYIYKKQNDGLASVIKMDEDEILEQLSKFYDHPKVFAAHDKEAASEGEADDSKEESRKEAHVIPVVEKHEENAGHIDGIADDEYPKNYDSYEDYKNNFEKYLHGLKHYKDGLYQGYGEGDSYGANGHHAYGDKGYKGYGTENYYGKGGAGDYHNKNYKSFYATGKGGHGKDYDEANKYGKHYAEGHGEKGGDHGHKEGHSKGEKVEGFHKVFDKDEFKKDHDFYDGEGHKGDFNKFSKGYEHHETNDGGNKKGESHDSGHTESGSGKEGHFDKESGADHDAGHSAETGGKSEQHGDEANGAKGDAVKGQSYGYEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM91</accession>
    <name>A0A194RM91_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">Disks large-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM91"/>
    <dbReference type="STRING" id="76193.A0A194RM91"/>
    <dbReference type="InParanoid" id="A0A194RM91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265306" evidence="3">
        <location>
            <begin position="22"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="252"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="383"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="530" mass="56491" checksum="1F705E2844A6F32E" modified="2016-10-05" version="1">MTTWMALFGLVWLLRVRGSLCGCAACKRARHDNQETRQTETQDTREPQCSTNSISYAPAEGPPFDVIALQNYTRDATVQTDFEDDEDLDKIELQICEGSNVANYDCGREQATQNPEVEQCIAGSLQSCSDSDDSIWETADVTLERGTNGLGLSIAGGESGGDISITRLAAGGAARSDGRLQIGDILLQVNEVSLEGAPHSMAVDALQKAGNVVKLVNEVSLEGAPHSMAVDALQKAGNVVKLRVRRARRPKVVTLWRGARGLGLGIAGGADDAAGGGGVFISHIAVGGAAHYDGRLRLGDKILAVRDEDGIETSLIGATHAKAVATLRNTGEHVTLVVLPAASIPPAAQPTQLYTTRTQATSCSTLHELTEEDPSKIPRCVRMVRLVRSGSRLGMDIVGGLGGEDTCSGLEEEACGVFVSGVSVEGAAYGMLYRGDRILSVDGRDLSRATHEQAAAALKQYSGSAVTIAAQYQPEHYERLRARIRAINAAAMSPHTMHPTHVPVHPDLHAVYPRTEIRIQKGLDLKTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNQ0</accession>
    <name>A0A194RNQ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNQ0"/>
    <dbReference type="FunCoup" id="A0A194RNQ0">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNQ0"/>
    <dbReference type="InParanoid" id="A0A194RNQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="761"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1122" mass="127934" checksum="36A3DC5FBE688F52" modified="2016-10-05" version="1">MFSKSLTSKDTFLEQTKAAREERALEKKRETSAIKIQAIVRGWLARQKFVKLILKEFDELLPEVNPHGSQEEPSPAFELIPALDVYKASCRLFLIFKQQRDRKRLEKLCKYIVQSLHSDSVKLSYVGVFLNKEYSLQWIAHIKVLLYKCCLYLEELKPESPIDMQSILILLHTLIAFTATNTWALTRLKNFDKLRGGMTQLCANIMGSLFHKGYYLTLKSLLLRGLCREKVSLKNISLTAIITLSLRPLVSAQFSEKLLTMYIIQILSVPTLIYHMQQISPESIAAFRSHAMFDKCLEFLSTDQNMRIVFNTLEGNYALCLLANLIQMAHLEREHALPESFYPTFVLVVTRFLDSCQQYVVLKKSNLSNWHPVLGWFSQSFDAFLPPAMGNLRNQLALLWGGPLLKKIMATPLKEMVEAGVSGEEGAGPSQPSTPIQSMNPAALIRRAIEARTSRSSSNKNFRRLGSPDSTKAALICSMYHTALQTMTQVKLDILTGLCNQDEILYSLWQFLCTLGPNCGLKSFLDLLAVNTKTSAPEFQMLILFADCMTHYVTILDDMEMYEQQDPFKLEDFIVMSQFLNMFVYKSIMGQLFDLKSISSNALFSSLHTLLLALYRRDCRRPYAPPHHWLVRDIRDNHFMADLEKGKKPQQVLVQKTPHMIAHGERVRLFRRAVADEKVVLGLTERACVSGLRSTLVTVRRARLVEDGYRQLAALPARALKAVVVLGLTERACVSGLRSTLVTVRRARLVEDGYRQLAALPARALKAVVRVRFVNQQGLDEAGIDQDGVFKEFLEETIKRVFDPSLNLFRVTSEERLYPSPTSCLQENHLQLFEFIGRMLGKAVYEGIVVDVPFASFFLSQVLGQTQQALYSWIDELPSLDRDLYRSLTYIKHFQGDISTLELTFSVDEERLGEIVTHELVPGGKAIPVTNENKINYIHMMAHFRMHTQIKDQTNAFIKGFRTIINPEGALSCLQRLISGDNVPLDLRDLRRHTLYYGGFHDSHRVVCWLWDVLQRDFTENERAMFLKFVTSCSKPPVLGFAHLKPPFSIRCVEVGDDEDTGDTIGSVIRGFFTIRKKDPLNRLPTSSTCFNLLKLPNYQKRSTLRDKLRYAVNSNTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNY0</accession>
    <name>A0A194RNY0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNY0"/>
    <dbReference type="InParanoid" id="A0A194RNY0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="194" mass="21791" checksum="DE1D6EA2160B3F5C" modified="2016-10-05" version="1">MSKRVCSQTKIRHVNRPYSESDIERPVPPPQPCRRSASSPPLTLTLDSELEDDVFVSPRTNSGSDPFSTTNLEIFRYGSPRTPAGLLLSPRRERSFTFSVTSEKHWRDKGGTDVADGVASADVRRPLVRDQAIIRDVRDGGKRNIVAEKDKNVCKGKGKTSYTGCAFVESVMEIANFEIEERMHYVIPFTFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQS1</accession>
    <name>A0A194RQS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urokinase-type plasminogen activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQS1"/>
    <dbReference type="STRING" id="76193.A0A194RQS1"/>
    <dbReference type="InParanoid" id="A0A194RQS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="56"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="277" mass="30219" checksum="1E7195842C9DEC22" modified="2016-10-05" version="1">MEFYKNRTRPSKAFSSFSMNYLNQNVVRPGRPGGSAEAVQCGTRTVDFSPRRTGKIVGGAETPYGAYPWQQPLHLDHIRIVVGEHRLKVQDKHEHRFLAEKVVLHPDFRKNGPHSNDIALILVSRSGAGVQFNSHVRPICLPDQSATGEGESDGRWCSVSGWGYQTEGTETFAPVLRAADVPLMDLDTCRKRQVLGGRQQPILDSMICAGVLSGGVDACRGDSGGPLACHAAGRWQLHGVVSWGSGCARRARPGVYTRVASYIDWIKLTASGMGHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRJ3</accession>
    <name>A0A194RRJ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRJ3"/>
    <dbReference type="STRING" id="76193.A0A194RRJ3"/>
    <dbReference type="InParanoid" id="A0A194RRJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="280"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="523" mass="58304" checksum="B08A5F5963F8DA5C" modified="2016-10-05" version="1">MPPNVVEPSFSPETDIGVESKNQVTAKPQEGINYNLYIFSSTLNLIAHILIGVVVGVAVLFSLRNGLPLGSTPMHIILCVIGHQLLMAESILSLSSENGWSSKLRLVDKRRAHWILQILGSGIALAGNFIKILDKSVHWNTYHGQFALVAIVFTVTSLINGLASLYAYEWRRIFNGTISKLTHICFGTVAFAASSISLCYGFDKFNFRTWATPSFTDTLIAFTDSEFKLHSYTETFVVQTYEMAPNTVETNFTPDPEMVTRENKTQNLPGQEVNYNLYIFQSTLNLLANILIGTVVGISLLFALRNGLPLGATSLHIVLCVIGYQLLMAQSILSLSGSGWSSKLRLVDKRRAHWILQILGSGLALAGSFIKILDKSVHWNTYHGQFALVAMVFTVACFLNGLTSLYAYEWRSIFNASISKLTHICFGIVAFGAACISLCYGFDKPFFRSWASEDFTDALIAFTGIFDLKQLVKLLEGKRRAGRRKKSWLRNIREWTGIRSAEELFRTALDREKFSKLAANLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB76</accession>
    <name>A0A0N0PB76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin interactor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB76"/>
    <dbReference type="FunCoup" id="A0A0N0PB76">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB76"/>
    <dbReference type="InParanoid" id="A0A0N0PB76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="990" mass="111001" checksum="5E2C97AC46461507" modified="2015-12-09" version="1">MDRFISMWKVRELADKVTNVVMNYTEVEGKVREATSDEAWGPTGQQMQELALATFTYEHFPEVMSMLWRRMLHDNRAHWRRTYKCLLLLSYLVRNGSERVVTSAREHIYDLRSLENYTYVDDLGKDQRSRVMCVKRSHVFIVGMSSEAAVMGVRSGGGGGGGGGGGWGEYSDRAAPGWDDMKERNDDDDYERDDSDGDYGHRKPQKENVYRDAEVIDTSPRLSRSERTERTEPLGKPLSINLRSPAKTKPSTPVKKIDLGAAASYGKSAATPPPAAAAAASVQNSQDLLDDLFKTCPAPSSGSASLVLEDDFDPRKDNAEILTDLILRLANSWSDVKSNNVSSLEDHMYISEILVLSVKYRTKLAKKYPWQLIELKNILFKGMSKHLDILAQELRCVGMATIEVIFNILAEIDETDRKAAEQLRFDYLGMGITCTNVHKTLKDLSMKCFLDKTSIKRITTKPETIDLKETLDSIAYRVIDEDLRPSHNTLVTSAVKSTEQTKAIVKAIISAKLEDMDKDKNEVTLDSDDDLQPYDMSNDVTEASKKRPMYLRDLLEILTEAKDLDTFEASVLAAEELVEKQLKHDDKKLAVDLLDLFVHLEQKYHVDNFDSIKFNISVAIVCSQPTTCAEHLCKEIHTDIGRYSIATKLFMLDVLSESANRIAGVKPRQEEKPKSIKVKQNDDVPAEEIIRRRLINKTKYFHTIRPHPFSKATINRFAAVSDSFFYPLVGGFGLKQLTLSHHNQKQDVDNILMLKYLSVIGNIILVSKNCPKCPNYCRDVMRMVLYLRFSPEPKIQSSVISIIASIILALPESMLRGEFLESMLEVRAWLIDCLSNLDLTMRLGGPKSEAAIFAGQVLHLLDKIVTLEGIQPTLGLLQPIAPNNNTNNQQQQPITTNNTKTTKVGATWADTTGAINIDVDNLLAPRSPKSAPAPSINQLKSSPNSPAHQPLPPTSFPMGFPTPLINNNYIIPTGTNNIRPPFTNQNSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBK1</accession>
    <name>A0A0N0PBK1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_02976</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460891">
        <property type="protein sequence ID" value="KPJ10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBK1"/>
    <dbReference type="STRING" id="76193.A0A0N0PBK1"/>
    <dbReference type="InParanoid" id="A0A0N0PBK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="114"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="347" mass="39576" checksum="F1D7A54E1767E694" modified="2015-12-09" version="1">MTGDMPLGSAHAFGRALLRDGALPPLEPGPPAAAPPAPHAPPAAAASPEQVMKLYMNKLTPYEHREIFDYPQVYFIGANAKKRPGLVGFPNNCEYDNEQGSYIHIPHDHIAYRYEVLKVIGKGSFGQVVKAYDHKKRENVALKMVRNEKRFHRQAQEEIRILEHLREQDKDNTMNVIHMFDSFTFRNHTCITFELLSINLYELIKQNKFQGFSLQLVRKFSHSLLQCLHALNKNRIIHCDMKPENVLLKQQGRSGIKVSKINLTRHEPKLVEWRSSRTTPVSSPSGRFKSVSFVFVVNMCSILSEANTADQLATPARPSLHQHSSLARPARCVLWRILYTCLTYRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBP8</accession>
    <name>A0A0N0PBP8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460869">
        <property type="protein sequence ID" value="KPJ11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBP8"/>
    <dbReference type="InParanoid" id="A0A0N0PBP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="93" mass="10864" checksum="3CD6ED1AC073F730" modified="2015-12-09" version="1">MRRKRSNISQRSPRAVAKKISRKRQKDDLEKLELQVHEARVRLAGMRQKYAEYLVSQQLLEAAEQTSQEKNDTLNTEIHPKELNRTDTSMGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBU7</accession>
    <name>A0A0N0PBU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460796">
        <property type="protein sequence ID" value="KPJ12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBU7"/>
    <dbReference type="SMR" id="A0A0N0PBU7"/>
    <dbReference type="FunCoup" id="A0A0N0PBU7">
        <property type="interactions" value="1906"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBU7"/>
    <dbReference type="KEGG" id="pmac:106713911"/>
    <dbReference type="InParanoid" id="A0A0N0PBU7"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031372">
        <property type="term" value="C:UBC13-MMS2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="17212" checksum="C53EB60834696FEB" modified="2015-12-09" version="1">MAALPRRIIKETQRLMQEPVPGISAVPSETNARYFHVIVTGPEDSPFEGGLFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAELWKVNESEAIRNAKEWTRRYAMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCB7</accession>
    <name>A0A0N0PCB7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein takeout</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCB7"/>
    <dbReference type="FunCoup" id="A0A0N0PCB7">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCB7"/>
    <dbReference type="InParanoid" id="A0A0N0PCB7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="198" mass="22349" checksum="2033585110CEEF36" modified="2015-12-09" version="1">MTKGIPALSVPPLEPLLVSGMNIETGAGPVVISQVYHNIQLHGLTDSRLTSYKADLKHYRLRTDSITPKMDFIADYVMKGRILVLPIQGKGVANITMVNLVVKHDLIGEPVIKDGETYMHIKDYKVKFIPERVILHFSNLFNGDKALGDNMNKFLNQNSDLVFNELKESYEKSLSSVFQDVTNKIFDKVPMNKIFPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCC1</accession>
    <name>A0A0N0PCC1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCC1"/>
    <dbReference type="FunCoup" id="A0A0N0PCC1">
        <property type="interactions" value="1938"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCC1"/>
    <dbReference type="KEGG" id="pmac:106713318"/>
    <dbReference type="InParanoid" id="A0A0N0PCC1"/>
    <dbReference type="OMA" id="DKVCRKT"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000003">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24443" checksum="485F44AC22892812" modified="2015-12-09" version="1">MKLLESGRLEALSRALSILNGDSAVQGRVESYSCKMAGSEKAFYKRFTADGETTHNLQALSPPEGVTYSRSLSGDEDGVLCDTISRKTLFYLIATLNAAFPDYDFSMAKSNEFSAEPSVTWAQGAVDAALSAVGGARWRQLRPALWAAIDDEVALADCRIYSYGPDLASDPFGEPGCLWTFNYFFYNKKLKRIVFFTCRAMSPVCAVDSGVDFAMDEDEEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCN7</accession>
    <name>A0A0N0PCN7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCN7"/>
    <dbReference type="STRING" id="76193.A0A0N0PCN7"/>
    <dbReference type="KEGG" id="pmac:106712659"/>
    <dbReference type="InParanoid" id="A0A0N0PCN7"/>
    <dbReference type="OMA" id="PRESEHY"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12336">
        <property type="entry name" value="RRM_RBM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="24537" checksum="96E51DEDCD1BDAB6" modified="2015-12-09" version="1">MIEEDNKTLWCGNLSEQATEELLYELFLQAGPLEKVRIPRERDGRQKNFAFITYCHEVSVPYALQLFRGTALFHRTLSLQGRGRLVPLPPPIRSYGPEPAIDFMYQHNIANQFTHMTERLTDDARHMIQYPIQRNDYNDKLTIASLQGNWSHRHHPYHSKDKGHKKDDFQPKDKHSDNYKSRGKQHNNRWRDRRNNKKNSGYHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDL3</accession>
    <name>A0A0N0PDL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460130">
        <property type="protein sequence ID" value="KPJ17520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDL3"/>
    <dbReference type="InParanoid" id="A0A0N0PDL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="38685" checksum="77232DD4C4CE6C2A" modified="2015-12-09" version="1">MIRKSSADTTSLKLRAYGFRQTVLATLSRTGTSAGQKLRLPKPGTPSTPFSAADSFNNNTPLNIPDKRVQSSQLAGDCVREERGSCLRPATRITNQTDSPKRHCPTLTALPAKSEDLLSLLLGQQIRQNKMFEGIVQLSQNQEEKISKIETKLDHSSPDSAPEDLNVSFADSTHSENRQDEDDEEVESNATPPNIWAPIESNDADENKGAQISQEESLRIQIIDAQRKLLELQKENPQHQTTETNIDFSPLVVESQVKIVKADSELAKQGSTYICQRLGEDTWKNIRYADVQKQFQATPVNIPDKRVQSSQLAGDCVREERGSRLRPATRISIRSVQQFYLSEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDZ9</accession>
    <name>A0A0N0PDZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDZ9"/>
    <dbReference type="InParanoid" id="A0A0N0PDZ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="816" mass="92096" checksum="734B355D68E54E7E" modified="2015-12-09" version="1">MITWYFQELFVPINTKGELYEVCPEELSPAEWEAVPGSAGGAPPGAAARAHRLPHLLSLWPLPARVRLLAGTVPIEMAHDVGEDLLLRAAITEPVLVMCSLPEGGPASPSRPADVRHPAREALQLLPLHGNLRVRRTQLGFDTEKRMFLSARLQKALTFCQLNVDNWIRQISYANSTLSSKAKTAEDLIKDHEPVKFEKEKKFTLQGLKIDPSRLFGKSEKVLKDIPDETEGSIIFLSKNELEHMNYDVYSEDEGKDEKSEEKGDQEQFTNDKMHVFREDSAQKKSKWFKNLKLLKSTEKLDDKITAIENNEKHRDVKDPFDPLGEKHSSIERYQDMAKLIEDRFGASRKSDGTAEKSHSYKSLTTSSSEMGTSQCSSNHKKPVLTKSVSVQTGMPDSPSTEEDSGININHGRKNLSVDQINYCGSMESNSSSGRKLKSLDENMLKKSSASKSSTNLERRQRIQPDLIPEKAIAKSESYNQIQSCEDINMFGAGSMYNDNDFEINYKQHSFITEKLCSEFHVKTKRVLSKSTSNLLHPKKPNEKKEGSNSNSMPTKTERSNDGEKLVNFRKKIDKPRAPSPKPETEEDIALDISEEPQRQVKIRRSISSIQKRKLPVIEDLPYGQVADAVDDEEEKIDSDTSSDNIYAEICTPNANKPTEEETYDIGVDVLATDPVICDVKKEVNIRNDERARQMIENQDNSFRHIEVVVIEKTTDFELDNSSLASSEFDDGGSKNDVSITVDSWEREKTSSHSDPKNHAIRLEITSNMEDYPIENQKHSIEINEVRLVKDNSLSFSNSIHLNGTYPNEAIYDTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE22</accession>
    <name>A0A0N0PE22_PAPMA</name>
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        <recommendedName>
            <fullName evidence="4">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE22"/>
    <dbReference type="STRING" id="76193.A0A0N0PE22"/>
    <dbReference type="InParanoid" id="A0A0N0PE22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="50906" checksum="1D294571BF0D8CD5" modified="2015-12-09" version="1">MEAQQIQLYQMKEKQARRMAEIEFDKMWHEVTMKEADALAARMEYDAIERYRRDVECKQYSDYQLEQRRRQRENEKEMLRQESLRFKAIWDAENKKEEDAEQARRDKAREIAEDSRRFLKLNQERLAREREEEKMVSDAWNSLASQGLANDMAMIELRRRKEVTEQARREKAKEIAEDSRRFLKLNQERLAREREEEKMVSDAWNSLASQGLANDMAMIELRRRKERELDECNRRLLEMKKKFVDMDIEDDIIRKEDAQQTQRKKDEISCRYLKWAKETTREVRKGMIEQIKEREEEKKLLKKRIDEEDEYHRQLREQLDKLVDYRDKMDAKVRKDHQRNLVKQIEYNNILKERAKQEELDQLKKYAIATKEYEEEIEKMLCRPFFSDHIHPFMKQMVKGVKMSEKCPCSKKDYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEA3</accession>
    <name>A0A0N0PEA3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459933">
        <property type="protein sequence ID" value="KPJ19292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEA3"/>
    <dbReference type="KEGG" id="pmac:106719970"/>
    <dbReference type="InParanoid" id="A0A0N0PEA3"/>
    <dbReference type="OrthoDB" id="7457027at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="18172" checksum="358B4F711DD0E149" modified="2015-12-09" version="1">MRCTRRFSPGTCAEAVVPVWTFDFFALNCTERLGCYLSTRSNRFNTYMYCLHSCRAFIDLYTQTLSEDDEQLKRLRSESRESIRRADGFHQLFYQTEDVYEDDQSEVWEGPASEGAERDDVIDVSDMLVPDIDYAGAQVNNEDCDLVHHMQTSKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEB2</accession>
    <name>A0A0N0PEB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459920">
        <property type="protein sequence ID" value="KPJ19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEB2"/>
    <dbReference type="FunCoup" id="A0A0N0PEB2">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PEB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF293">
        <property type="entry name" value="HERMES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="519"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="716" mass="78746" checksum="2F00C77F24237187" modified="2015-12-09" version="1">MAATAPISEGKETIDEAEEKLLDKSRAVIVANEDGQTTIKSSKKVKLPEDESPAVGAGRFTIGPAPERDWEMVPPDGKWGWFVLVGATLVNILIPGTIKSFGVLLVEFRDVFQASESASSGIVALCYFLYSSLEDEPIEVYKMATHAINENNGIPEEKLLKDTSENNLSQENVHNSQNCMNSTQNLRHNLSKRKLSYTRPISKANYSSASIAQDGFEKRLGSQETFGRRLSTVGPKRNMSTSSFAYVSTHFHGSTLSAFEKPNEFASQFSLKSITESVADVAYCCFCCKRKVKSEPNKFFDVTLLTDPTYLLEPFAEEDPIDLEASHPRLVLTSEDNTPTDKYPNSSPPIFKHKSNLALDDRSPNKLDFARSASAAQVMRLTDDRARKISTSSRHGLSQISSKISNYLPSNPSLLESVPEGKSSRTNSHDTFGRKLTVPKTPKRSPSTSSFQYMSTPFHGSTLSAFEKPSEFASQFSLKSVTDSLAPITYCCGCRKKTDDNIKKEPSKYFDVQLLKDPIYLVILISNCTCAISYTNFIILVPSYAVECGFDKSLGAYLLSIISALDLVGRIGGSAISDVVSTPKRYFFITGLLISGISLAMIPLMKSYLAISVFCSIFGIASGINVGVTALVMTEMLGTERLMSSYGISLFVNGILQLIGPPVCGVWFEYTHSYKSLFVTLGLILCSGAALWGFVPFIHSRRKKAVRMQQNLEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEY4</accession>
    <name>A0A0N0PEY4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459761">
        <property type="protein sequence ID" value="KPJ20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEY4"/>
    <dbReference type="FunCoup" id="A0A0N0PEY4">
        <property type="interactions" value="1538"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEY4"/>
    <dbReference type="InParanoid" id="A0A0N0PEY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000141">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="334" mass="36385" checksum="7FE4988A45934841" modified="2015-12-09" version="1">MAAGPIAERNQDATIYVGGLDDRVSESLLWELFVQAGPVVNVHMPKDRVSQTHQGYGFVEFMGEEDADYAIKVMNMIKLYGKPVRVNKASAHQKNLDVGANVFIGNLDPEVDEKLLYDTFSAFGVILQTPKVMRDPETGNSKAFAFINFASFEASDAAIEAMNNQYLCNRPISVSYAFKKDVKGERHGSAAERLLAAQNPLSHADRPHQLFADAPPTMMGPILMAPPPPPAPSPMPPPGPPMSGRPPPPCRWQHLHHLLQPCLHPALHRRRDRHLPRHLSTTSPALRPTGIRSPPRPARAPTPVETSTTAVQATVPSARSSAVWSSAIPPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFF1</accession>
    <name>A0A0N0PFF1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="LADJ01027707">
        <property type="protein sequence ID" value="KPJ21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFF1"/>
    <dbReference type="STRING" id="76193.A0A0N0PFF1"/>
    <dbReference type="InParanoid" id="A0A0N0PFF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="139"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31604" checksum="7C9F83236A9AA5D7" modified="2015-12-09" version="1">MLATITWWTSSRSASCYSDSSASGRGPSITSTMDFSMPYVERYEVGLEETRVALAAEVFGRYLKPEGGEAVTDVVVPTVVDDACSLLEGGSKDIFGECVRCVKSFLAGAPFAEFERSMYFHRYLQWKWLEAQPVTQHTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMVLIEKQILQRINSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMCGADTGLGLERARFYAAQVACGLEHLHKMGIVYRYIKTNYTTLYNMPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFT9</accession>
    <name>A0A0N0PFT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01062157">
        <property type="protein sequence ID" value="KPJ21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFT9"/>
    <dbReference type="InParanoid" id="A0A0N0PFT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9749" checksum="84E77286DD062575" modified="2015-12-09" version="1">MPSKKPQAVKSVAIVLAENSPYPRRDGNGKRTKNKQSVTTLIRRNVELLPLHACLLFLQVECLGACVNAPMIQVNDDYYVSTILFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I699</accession>
    <name>A0A0N1I699_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-33B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ07003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I699"/>
    <dbReference type="STRING" id="76193.A0A0N1I699"/>
    <dbReference type="KEGG" id="pmac:106719358"/>
    <dbReference type="InParanoid" id="A0A0N1I699"/>
    <dbReference type="OMA" id="PLWIEEC"/>
    <dbReference type="OrthoDB" id="10006973at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04115">
        <property type="entry name" value="Rab33B_Rab33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041822">
        <property type="entry name" value="Rab33A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="224" mass="25099" checksum="5DD978EED27F3111" modified="2015-12-09" version="1">MTGSSNDHNIAGLKQKKVFKIIVLGDSGVGKTCLTYRFCEGQFLDKSEATIGVDFRERTVRICNEEIKLQLWDTAGQERFRKSMVQHYYRNVHAVVIVYDVTKPETFHSIASWMQEVESHGLTGAPRVLVGNKCDCGTPESRLATAYAQRLADKHGMPLFETSALLDSECDNVESIFMTLAHKLYSKQPLRVVRVEGEPGYGVVTLPRQRKPHVTTGTDNCLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9Y6</accession>
    <name>A0A0N1I9Y6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoredoxin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmac:106721190"/>
    <dbReference type="InParanoid" id="A0A0N1I9Y6"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="21094" checksum="860176570E520224" modified="2015-12-09" version="1">MSMSVDAEAVCAPYNWVDAASVYDKRGERVPADRLRRASAIALLFTSRGVDRDGVIARFCRIYQDIRELHLPLEVIYVPMDDTAQDAAASYSEQPDWLTLHFDDTLVHELRYMHEVTCIPQLLVVRGDGAVISSHGISDLEEYGRNAVLSWLPSAACSAARGDHTDVHRVFTLSHDHHIKFGDVKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA59</accession>
    <name>A0A0N1IA59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA59"/>
    <dbReference type="InParanoid" id="A0A0N1IA59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13243" checksum="4E1F5AB96FD0DDD2" modified="2015-12-09" version="1">MLSIPIAAYPPSAQAHAAASVSGSRAMAPAAASVVLFRVAVAASRGRLSHHKSASIHDASGLSSWLSSNFAPILFKAMTAPTAFAHRFLMTYLFSFVLVTCSSVQRADWINHGCLNVAEAERRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBY4</accession>
    <name>A0A0N1IBY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 571</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBY4"/>
    <dbReference type="STRING" id="76193.A0A0N1IBY4"/>
    <dbReference type="KEGG" id="pmac:106720868"/>
    <dbReference type="InParanoid" id="A0A0N1IBY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="413" mass="46949" checksum="CB146D11130F0667" modified="2015-12-09" version="1">MTEDAFCPRGICVSCTDAGINAYEFRILTKNSNKVWSNCVNGLNKAIDSGKPPNSLYTVMREDLSVLSVNNNFNGDSKSLLNHLINRVSKKKHMEVEKKPRAARSGPPCKCTDCGKLFNSPYYLTLHLKNSGQKEACALCGTMVFRGLEMKEHLQAAHGKEVHMCTDCPMLFTHDYELKQHTKRAHRAGALTCFDCGRTFPRNASFEVHAQMHAVRTCRACGAQFTNRACYREHRSNCEPGAKPDTKNVPRSRRSNIRDPATFICDYCGKTYLSRPQLKNHIVWIHMDIRPHQCQWCGKRFYTPTRLAEHSVVHTRERNFECDICGAKLVSKMAAVYHRRRHTGEKPYECQSCGEKFISSSRRSEHAKRRHGLGSKLQCMDCPATFVRIHELKKHIAKVHGTQNSDLSITARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFM5</accession>
    <name>A0A0N1IFM5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFM5"/>
    <dbReference type="FunCoup" id="A0A0N1IFM5">
        <property type="interactions" value="1651"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFM5"/>
    <dbReference type="KEGG" id="pmac:106712989"/>
    <dbReference type="InParanoid" id="A0A0N1IFM5"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
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        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
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            <end position="339"/>
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        </location>
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            <end position="40"/>
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        </ligand>
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        <ligand>
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        </ligand>
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            <dbReference type="RuleBase" id="RU003405"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ13039.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="35385" checksum="7A5C76E4C67F9582" modified="2015-12-09" version="1">MFSRALKPVASVAVQNGAKFSTTSQKNFKVVVAGAAGGIGQPLALLLKQNPLVTRLALYDIAPVTPGVAVDLSHMDTPAQVTGHKGPEELAAAVECADLVVIPAGVPRKPGMTRDDLFNTNASIVRDIADCVAKNAPKAIMAIITNPVNSMVPIASEVLKKAGVYDPAKVLGVTTLDVVRAAAFIGEINGVDPTTVKIPVIGGHSGVTIIPVLSQSSPAVKLSDQGKIEALTKRIQEAGTEVVKAKAGGGSATLSMAYAGARLACAVLRGLKGESNVVECAYVKSDLTEASYFANPVQLGRNGVEKNLGFGQLNAYEKELLKAAIPELLKNIKTGENFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFR4</accession>
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
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        </location>
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        <location>
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            <end position="424"/>
        </location>
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        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10134.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64479" checksum="F3EA3D78C250D2FC" modified="2015-12-09" version="1">MAEDEDGVSNKNSPQNSNDADSNQENEQNAVKPDLGIEEAKYNSQENGHASPTKPKSSSTKSTGAVRKEENPFSFRHFLKRDLSLPGNSTYENTGARPKAYSSTVQHSPTKVDIHTESRREKNRQHDNQTKDKVSEGASHRLNDNVPSTSSMDVPFRVVESLNCEDNFYSENADVSFYRKPNLASEPMGMPSLPDFVQDHILVEQAYLHSNGPMSLDLDNLPDFTFNTNFNAGSSSSLGRRNDNNYVGNRGYDYDPYMGASTSSDSGPSNRNIPLDLPAGAEAAGPVPLDHPMHLSLDLTESVNPSDRRNMSPRNQFPLDLPPNAGAESKRLPDFLPVHPGRTSPEPEHQDEQLQQIMSELERTRSELFTERSRRCRAEQEMANARYRLNERERAFREHVCRPVVTPPTETSPAPEPPTEVRNADPEVVSKLKNEIKKLKVRNADPEVVTKLKNEIKKLKEQLRVSQEEVRVLRGAQAGAAADLRRASRLAETSLRRSSAARTPGTAATPASSSPSAHSGRLQHGYIPQGQMIFAVTLSISQGLELLTLSLAEGGAGLAAARRPGHTLRQRPDEALLHLAHGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFS4</accession>
    <name>A0A0N1IFS4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">RR48_01423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460648">
        <property type="protein sequence ID" value="KPJ13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IFS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="473" mass="54426" checksum="3D2149F76180E600" modified="2015-12-09" version="1">MEEEEDFVGCISCMNNKDLCDLFAIYADNEETYAQMLKSCYNIKISTEYKFICSDCVEKLEKAAAFKSQTSKNLAMLQSIKDEEYLDESILEEGESLTVDCRHKNNHLTSTEDADDINEEHEIQALDETTCIYCNVQLPTAEEIDQHVRMVHGLEPRTGQRVRECSLCGASLSDLADHINRCHSASESENRQYACHFCDNVYSSKKACFTHLRMKHGLKLCNDHTPKYSPTDRKKCHICQRDFSQKQILNNHLWKAHGYEVEKRKAFFCPLCNERVSYGTNFSAHLLHRHQVREQVEQLEFGTMDDFMLFKSAIQEETKFRFRKTTASKQTIEGVRSHYMCSQSGIYVYQGKGKRPAPERQIYKTGKACPAHMIVTETMDRVLVTFYKTHVGHGTCPYYEPREPKRAKCEEAEGCPQLVCDACGAGFSATDKFKTHVASHGLKLFPCEHCDDLFQNIDAWTRHVRIEHDTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG78</accession>
    <name>A0A0N1IG78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myelin gene regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG78"/>
    <dbReference type="STRING" id="76193.A0A0N1IG78"/>
    <dbReference type="InParanoid" id="A0A0N1IG78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="7">
        <location>
            <begin position="254"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="3">
        <location>
            <begin position="254"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1191" mass="135067" checksum="1245FFC0B0BDA268" modified="2015-12-09" version="1">MTRKMILKDIVRKKGKKGELIVVASLIDKLPNLGGLARTSEVFGIKTYVIDSLRHLQDKQFQGLSNRICICDLEWIYGYEVDKKQMTNIKKQPEKMKGPGLIDELEAFMAPVGDVCYPPQPLDARRLGGHQLPESPPDSGSENPYSPSEPGHAAHSIAVSQTALAGDYMLVHDHIPTHEILQQNGDYIYEELKSDNLDHEVLRGNLNDVVVIPQDPNIVELGIRTVRHDLGLDQITYQNRYNQMRVEMPELDQGLINPQLVTIGHEGATLTPVYTNLQEPSSKKRKHSQDIKCEPAALSPESVSHNPRPAPPSVDGSEAGDDVPMQCIRFAPFQQSAWHLLYDCNLKPLPNPSYVVGADKGFNYSQIDEAFVCQKKNHFQVTCQIQVQGEAQYVKTNEGFKKINNFCLHFYGVKAEDPSQEVRVEQSQSDRTKKPFHPVPVELRRDCAKVTVGRLHFAETTNNNMRKKGRPNPDQRHFQLVVALRAHAATQHYMVAAHASDRIIVRASNPGQFESDCSEGWWQRGVSDNSVHFTGRVGINTDRPDESCDRIFMENLGAVKELCKVTGHLESRIEQLERVSKRLHRRDSARSSLSNDSRFSGLSTSSKSFYSDGNISIDQIRDIARNIRKHECCHKLSHNSPKYTRKQCKNCHGNYTKYGKYYNYNKTCVRYHSNKSDKVENTDYPTYVSSLESSPTPKPDETYSIVSKQKDSCLWLRDEDSLAYNSKLAFCCRRKDRFGDASTELVSNKFLQIVITILIFIMAICLVVMTALYFREHQELLSMKEIRLHEKFSNYPHYGKFNVNGGPAHRATPPDQNQIQNLKPSQHVAAKKSVKEKGPHKTTPEYTTSTPADISHSTTTAVHASRNYVRNVLNMEQRAAPLRAERPAVTRVADVVGGGCTYTLNADNELDAECQSCGLEPPQTFENQEPLERSSPEKDLNETYTRNLDQTFKEIPSIPVILEKNNSDALKNENDSLRNQIHEEILAESNLLDPNKQNGTEVRMKRELRHRDPKGRREVRETNEALLRSSSEEMTLTEQSDEVPLSQGSECESVSVGVWSAAAGAVNTSLFSEAVCARALYNFTYGVPLSHCLHHKELAITFRTTKLKELRLCELYCKYDTMKNCQMSREIAKPLPSGDTWISKMNLDCNMDRHMKIRAAFAPLKDLCYLNAEHKIPFVEYNIHIYRDCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGA2</accession>
    <name>A0A0N1IGA2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pupal cuticle protein G1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460535">
        <property type="protein sequence ID" value="KPJ14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGA2"/>
    <dbReference type="STRING" id="76193.A0A0N1IGA2"/>
    <dbReference type="InParanoid" id="A0A0N1IGA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="24180" checksum="9F8CF2BDD8FC4AAA" modified="2015-12-09" version="1">MRISSLPTQAGYASAATEEKCVIIFMCVAGIASAGNLLHAPIAYSAAPAVSSVSYSTHAAPITYAAAPAVNTYAASPVITKSLAPSVSYQSISTHSAPSLYAKTIATPAVATYGAPVLSKTISPAVSYSSVAHGPVYATSPLVAKTYAAPVIAKSYSPAVSYSSVSSHSAPVAYSAPLVTKTIATPAVTTYAAAPAYSTYSAAPAYSTYSAVPALKTAVTYSAAPAVSHVTYTGLGASYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH66</accession>
    <name>A0A0N1IH66_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH66"/>
    <dbReference type="FunCoup" id="A0A0N1IH66">
        <property type="interactions" value="1974"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IH66"/>
    <dbReference type="InParanoid" id="A0A0N1IH66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="8">
        <location>
            <begin position="107"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="620" mass="72192" checksum="8697DA8C887FF924" modified="2015-12-09" version="1">MYPSMENFLMQSKQKLYRGEEFEDELNDLFNKKFKFRYNSEWTLPSGDTWFTDAPWKVKGLEYLKSRLNFHKSQLNDFSIEEWSSHTRRRNPAGEVCWKLRCLVNPEFLTQAWTKFYECASTYNIVPPEAISDMKMVSLHLCEAPGAFITSLNHYLKLHHQALDWKWVANTLNPYYEGNSSSNMISDDRFMFHTLNNWDFGVDNTGNLMDWENSQAIIKKAKSLGKVLLVTADGSIDCLQKPDAQEEVTSPLHYCEIITALQALSPGGTLIFKLFTIFEHSTVNLLYLLNQLFKEVNIYKPITSRQGNSEVYAICLQYKGIDLKSYIPIFQSAFGTEFYSNKSLFPLEKIPESFLKQIEECAYYFCSIQCHVINNNLQAYLMQKNIALHRDMKKIRAIVASEFIWKYNLKPISINQELLKGTLHEENKINTNPRYHRGSYTERQLYTKMSLKEKHKNLNMFLQAEMLSNPMIHITEPVKWMIGEGSSKIDIIFTYGKPLQKVNSSKFIFVPIYKLYQQILAEEEFKEIILYRPAKPKIDPSLLGPEPSKIISLPEFQYRESYNVYEKNCFKALLNGMKELLDGESILLQNFNTLTHFNVSILYILSKACFEKTGSLLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHK7</accession>
    <name>A0A0N1IHK7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHK7"/>
    <dbReference type="InParanoid" id="A0A0N1IHK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874061" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13429" checksum="B6945F4B18927735" modified="2015-12-09" version="1">MCYGTGGALKAMLGVLSALVAADVAGCSRRDLLAMLVAPVHTMHDHNASAHHIKQSNVNNTSTVSRRQHRRNPPPGPARRTNEKSIASTVPTEAAFIPLSHEDGFSKTKLQLKLSHKEKKNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II11</accession>
    <name>A0A0N1II11_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LADJ01031199">
        <property type="protein sequence ID" value="KPJ21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II11"/>
    <dbReference type="STRING" id="76193.A0A0N1II11"/>
    <dbReference type="InParanoid" id="A0A0N1II11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="159" mass="17981" checksum="F3B226306C16D8AF" modified="2015-12-09" version="1">MKNVKVTYFDAEGVAEAIRWLLAYGGQEFEDVRVGFADWPAFKPKTPHGVMPLLEFDGKVYGQSFAICRYLGKKYGLAGKTLEEDLVIDQNTNFYADVRLNGIQSFWEPDASVKAVKQEALVKTVYPELLPKLEKILKENNGYMALGRVSLNSNIFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIC7</accession>
    <name>A0A0N1IIC7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459895">
        <property type="protein sequence ID" value="KPJ19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIC7"/>
    <dbReference type="InParanoid" id="A0A0N1IIC7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="258" mass="30613" checksum="10243CED9703E420" modified="2015-12-09" version="1" fragment="single">ILVGYNNLERLFEYANKREDNYNKNVFDDNLALAFNTIDKDHVKLVRNSYIEDEDVSVTVKYDLAEFYSDFSFIYPIHRSLPKYLENGAKIFYYVFKYAGGRNFVKLRENITGPGAVHSDEKVYLFDMTVLPETNTPEDQAIIDKITIMWTYFVKKIWVNILFLLRGLTRPNPINSTDHHNPMNLKFVSLFFQRSYSETTELLSVKWIPISKDALNYLEIDKELTLKKRPKQTQMAFWDLYYKINKQHLKGYRSTDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIV4</accession>
    <name>A0A0N1IIV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459692">
        <property type="protein sequence ID" value="KPJ20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIV4"/>
    <dbReference type="InParanoid" id="A0A0N1IIV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873989" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7379" checksum="7DF360BD96700CA4" modified="2015-12-09" version="1">MRGAWQAWWLALALAAAVAAQTDTRHLSEDAALRGCVREERLRTLHQSTVVSASVHAHSRLDISSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJY3</accession>
    <name>A0A0N1IJY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01058192">
        <property type="protein sequence ID" value="KPJ21589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJY3"/>
    <dbReference type="InParanoid" id="A0A0N1IJY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9637" checksum="B3776649B3ADDD75" modified="2015-12-09" version="1">MRRGDESLEKIIVVGNTDGKRSRGRSPIRWSDQVKGQSSSDFYAVVRDALDRSRWKRIIYSGTNPDADHDPQTRGTDSRERMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INC7</accession>
    <name>A0A0N1INC7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INC7"/>
    <dbReference type="STRING" id="76193.A0A0N1INC7"/>
    <dbReference type="InParanoid" id="A0A0N1INC7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000181">
        <property type="entry name" value="CALML5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000419">
        <property type="entry name" value="Calmodulin-like protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31200" checksum="3F95ECC2CA0FB58A" modified="2015-12-09" version="1">MAVPLPLYLCSNFCELGRRASACCTLSTKPANIFSAVNNFFADSPLVNQLKVIMFNKAIYCSQFSQRSISPVRSQHQVSFLKPAANTNLDRKASIVDETTGISRTQMKEFREAFRLFDKDGDGTITKEELGRVMRSLGQFARVEELHDMLQEVDSDGDGNVSFEEFVNILSKSMCAGGGSSSAEQEERELRDAFRVFDKHNRGYICASDLRAVLQCLGEDLSEEEIEDMIKEVDSDGDGRIDFLEFVRALGEPEDACDDEDDEDNTDGHDGLVQRTVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPC5</accession>
    <name>A0A0N1IPC5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPC5"/>
    <dbReference type="FunCoup" id="A0A0N1IPC5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106711215"/>
    <dbReference type="InParanoid" id="A0A0N1IPC5"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF11">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="26119" checksum="DCEAD0CA54662BDF" modified="2015-12-09" version="1">MWTVCVPGWGAALAAGALLLYGSLDVAYFARMMYTVARARYFRKKACILETTEVNSWCLLNDIDTLLYHMNNARYLRELDFARADFYERTGLYANIRAAGGAVVQAAATIRYRRYLKPFTRFKITSKAVYWDEKTLFMEHEFVGPGGFVHAVAVCRQRVIDTSAAAIAELLLQLHCAGTCQPTPAKMPPELELWVQSNEISSAKLRAPQMPQSILHTSHNIGCGEMVPSLNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ13</accession>
    <name>A0A0N1IQ13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like subfamily C member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460041">
        <property type="protein sequence ID" value="KPJ18349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ13"/>
    <dbReference type="FunCoup" id="A0A0N1IQ13">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ13"/>
    <dbReference type="KEGG" id="pmac:106721353"/>
    <dbReference type="InParanoid" id="A0A0N1IQ13"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052317">
        <property type="entry name" value="Viral_replicn-host_int_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="616"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="857" mass="97933" checksum="473B1E3A5969C7AC" modified="2015-12-09" version="1">MARSPTDDLRFGDIPLNSWNFCTETGDNNQPAPMNERKPTPIPSNPATMAENNIYNTPNYSKDVYLNKHHFNVQTNECIGNKEENCSYNVPNGSIGNANYGNAMLKLDNGQLVRVFYDENNQQLIFPKSGQYELFNNNQGLCDMSMQQHNLFNMNQDFSVPNNVHIPPPTNVPSNSFCQENMNVQSNMQTSNFIKEVIGNWEPNSSGTYSPFGQNYPLKHPEAPSLNILPNNTILDPITQSLKSESSPKRNENSPLADTSNKKRIVAEVKPMRPSYSDVLAKNTKNNPQPENTRKVKPQGVETKNKLSSKNDKPLTNAKCNDDKHKIDKKQANTVSSGSESGDINADDTDRNKRPNKKSKNKRSNMTRRWSSLDDLNDENGMKFEKSNESQFVFIQNNSDKSHKKDKKENKTKNVEKSNIENDFKIDDDDDEDDQSQFILHNGQTETSKVKKRKEGRSYHKTPKPAQDKKKPNQNKFRRNKPGYLGLAQNWLEHWADVTWKAIVWFFYLLSDICGMSLHLSFDLCTSAFTQTYISSQAVWRSSKDWLSKMADNKFLLYIDRKLGHTYFGFWRKLKWFKKETEVETNSNATKLNTNIPLPATGEEAMKRLLACKGKDPYSILGVSVTCSDEDIKRYYRRQAFLVHPDKNPQPGAEEAFKILQHAFDLIGEPELREAYERHALESRHVEAAWSELSQLLTQLQDKMEFAANTIRCTNCGRRHKRVLTDRPCYAARYCAQCKIRHSAKEGDIWAESSLMGLLVMYYACMDGGVYQITQWASCQKKNLKQLRPDWHVVQYRIVLGNKAADVNHSPAAAPTGHDPNLEEFLNNLYSKSGASANNASKPADVDKRRRARKQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ89</accession>
    <name>A0A0N1IQ89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459920">
        <property type="protein sequence ID" value="KPJ19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ89"/>
    <dbReference type="FunCoup" id="A0A0N1IQ89">
        <property type="interactions" value="1101"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ89"/>
    <dbReference type="InParanoid" id="A0A0N1IQ89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="41038" checksum="C9329ABB3028694F" modified="2015-12-09" version="1">MKDGEGIKVPNSLGLRLKSICLKTNEYDGGALVSESGVDKAADFASALSAFCHIIDKIPELPLVVSDKVQEINKTKQAVIFLRRIKAWSDNSKIFIPELPLVVSDKVQEINKTKQAVIFLRRIKAWSDVLKVYKSQRLRAGKGKMRNRRRLQRKGPLIVYHKDQGLTRAFRNIPGVDMLKVDKLNLLKLAPGGHVGRFIIWTKSAFERLDPLFGSWKTPSKEKKNFNLPQPKMANTDLTRLLKSEEIRKVLRAPNKRVIRATRKLNPLTNTKAMLRLNPYSAVLRRKAVLDQQRKSNARALALAEKRGIKLPSSDPAVKAEKLRERRQKLLKLAAAKKTKKPAAKKTPPPPKKVKKEKAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQT2</accession>
    <name>A0A0N1IQT2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035395">
        <property type="protein sequence ID" value="KPJ21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQT2"/>
    <dbReference type="InParanoid" id="A0A0N1IQT2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="6757" checksum="AA8C289BD37B1CD8" modified="2015-12-09" version="1">MFKHTAGIHPYVVDIRTKRFESSFLVRTAKDWNMSAASVFPSKYDVGASKSRVNRHLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PF70</accession>
    <name>A0A0N1PF70_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PF70"/>
    <dbReference type="STRING" id="76193.A0A0N1PF70"/>
    <dbReference type="InParanoid" id="A0A0N1PF70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="OCEL" evidence="9">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="586" mass="67140" checksum="63B51DB5A24B4EC4" modified="2015-12-09" version="1">MEGPQGSFECVRGGAGARRLECCGPLPRRMRVLANDDSYEATKDRMARTVAAEQSKCTRVIKPNQTDIGRRINKRLSHTTYSNGSAAAQLAERAERAEKERLERLERERAERAERERVERAERERVERAERERVERAERERAERAERERAERLERERVERVERERAERAERERAERPDRAERAERAVPRGAPPPHQRPPPAADVSRRSINERLIQLLALKPFKKPELYARLSSEGIKEKDRAEVNKILPKIGSLKDNCYHLRRHIWNDVNEDWPFYTEEEKRMLKRYLPFLRVFSSVKSSSPSGQPIRSFIISDTTSIRPLDCQLLSAPIKEWDTIVPIKKDNGYTLNFNTVKDLCPSPVKPNGFRNSPTVEQTSITEKDITNTEQLETTDLTSVPDENMTDLVDIERQYPAITSSGTRRAYKQEFSELYTEYRALYARVAQVAALFSQLEQQLRRTEPASPQRRVSTPQLETGARVCGEHHAGVLTLALPARRPLPLVAGTAPPAAPRPRPAHHTRHRANYAPTAHQLRTNCAPTALNCAPTPSARSDTWLVHRLIAYLHMQMLVVAYAAMYLRLSMFVSRGCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGI2</accession>
    <name>A0A0N1PGI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGI2"/>
    <dbReference type="STRING" id="76193.A0A0N1PGI2"/>
    <dbReference type="InParanoid" id="A0A0N1PGI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="FA7DFADE86DD98F0" modified="2015-12-09" version="1">MDICNTRVIADVLPAFETVLKIHLNLRLGIRYTICMIHISRYIKTFLVTLMDKRDVPKIYEVDFQPYHMNNLSVLGGGKCPPGWDAVAGTCYMYVGAPMTYEQARLFCLVLHQCGLVVIHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHX6</accession>
    <name>A0A0N1PHX6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDB1-and CUL4-associated factor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460041">
        <property type="protein sequence ID" value="KPJ18369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHX6"/>
    <dbReference type="STRING" id="76193.A0A0N1PHX6"/>
    <dbReference type="InParanoid" id="A0A0N1PHX6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="172" mass="19443" checksum="A592111AF1672DD6" modified="2015-12-09" version="1">MANFNYVGNIQIHPPTDATKQMLILRYLTPMGEYQEFLSHVFEQNALGLILGYLNVRESRDSRLAFEALKYLAALLCHKKFSIDFINMGGLQKFLEVPRPSVAATGVSICLYYLAYCEDAMERVCLLPRATLADLVKLKVQYIQSNGRQYRGEEKRADVTSPTASIPLINCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIK7</accession>
    <name>A0A0N1PIK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein YIPF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01066038">
        <property type="protein sequence ID" value="KPJ21680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIK7"/>
    <dbReference type="STRING" id="76193.A0A0N1PIK7"/>
    <dbReference type="InParanoid" id="A0A0N1PIK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="17556" checksum="A60636C805D9AC29" modified="2015-12-09" version="1" fragment="single">VHWRYDFHLVSYAATAIFCYVWLVPLALWAALKWTTQTDGHDEIETQQSTSPTMMSLFCLYGYSLSIYIPVAILWTIQVSWLQWLFVLMAAFVSGAVLIFWLLPALRKSKYFLILVGSILAFHFLLATGFMLYFFHVPDTDVAVKVSTTTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIU5</accession>
    <name>A0A0N1PIU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460778">
        <property type="protein sequence ID" value="KPJ12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIU5"/>
    <dbReference type="InParanoid" id="A0A0N1PIU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10473" checksum="B25E6B6C61AD9D31" modified="2015-12-09" version="1">MDSSLLEGSSLKELLGVIQYEAKKLEEDIRESTARLCVQDLNSNLLIIQHSDIYYSGKFIIKNELHCNIIESASQGSHLAPSPPVSKTHFDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJW2</accession>
    <name>A0A0N1PJW2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathione S-transferase theta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJW2"/>
    <dbReference type="FunCoup" id="A0A0N1PJW2">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJW2"/>
    <dbReference type="KEGG" id="pmac:106712265"/>
    <dbReference type="InParanoid" id="A0A0N1PJW2"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03183">
        <property type="entry name" value="GST_C_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040077">
        <property type="entry name" value="GST_C_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="26375" checksum="FAAA2BCFDE3E5038" modified="2015-12-09" version="1">MALKLYYNLMSQPSRALYILLKATKCNFESNYVDLRKGEHFTEGFSKINRLQKIPVIDHNGLLLSESVAIVNYLSREGLIPETLYPRVSRTRALVQEYLEWQHVGLRLHCAMYFRVKYLDPILLGRTPSEEQIKGYEERMVSALELLETKWLGRGTDFIVGNNITVADLWAACELEQPRMAGFDAKDKFPNIATWWAKVRQNFNPHYDEAHIILNKIVQKQQKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMR7</accession>
    <name>A0A194QMR7_PAPMA</name>
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        <recommendedName>
            <fullName evidence="7">Transcription factor Adf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMR7"/>
    <dbReference type="FunCoup" id="A0A194QMR7">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QMR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31848" checksum="A8637CCAB075C8AF" modified="2016-10-05" version="1">MDDEKLIETVRKYEFIYNLKHPRSMDNAKKEIAWNEIGEQLNQSAIACKQRWQCLRDSFRRALKHKRDRGEAAKGIKPWKYEKEMAFVAPFFMEKKTKNSVEITSEDDLSYNAHVSYGTEALENYININIDDPLANNDSEEVINNKSWQKKSNKKLKAVKRKAAQPVSSASPVLTTNVTTFDDEKNIEPVRGHDELDRFFLNISDTVKKFSPYLQALAKNKIFSIVSEMELQQFQMEVQTTSTPFTFKASPQSESPTPVPTTSDDWTGDQKLQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNR7</accession>
    <name>A0A194QNR7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNR7"/>
    <dbReference type="STRING" id="76193.A0A194QNR7"/>
    <dbReference type="KEGG" id="pmac:106719107"/>
    <dbReference type="InParanoid" id="A0A194QNR7"/>
    <dbReference type="OMA" id="SKDIPKH"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24653" checksum="AF227DDA2144748E" modified="2016-10-05" version="1">MRKRKSLKKADDDSDGSEQGGEPEEFQDSGEDWTPDADSNEQSTRGGRKRTSRAAVNNSKKKRKNSTSEESEGEGEEDEEAEDEEGDLDEEEGSDEEKNGSDGNKSDSSQSKDVPKHFHSGNFVLLKSDVKWDGDTVVSKLDELNLWKIDGKALLQKFIPMESNGKILHKCTCVYSGWNVDNRENYYPITEILDRNPRTDSKEICVALNLDDLITVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPI0</accession>
    <name>A0A194QPI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPI0"/>
    <dbReference type="InParanoid" id="A0A194QPI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="17640" checksum="ECB0BA60EEFC540B" modified="2016-10-05" version="1">MCRVGAGSAGAERAPTGPGRGHTYYVINPRPPTLAAPRRTRAGFPRPRASRPLATHGAPPPAPRSAAPAARRPPPAAATRQSRRDQRRRRIVCDCAPAEPTYDIIHANLRPLIFLPSDRSETAAISRVPNVLGRRPCTFPSDTERAHETSSECRNAPSDEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQG3</accession>
    <name>A0A194QQG3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General transcription and DNA repair factor IIH helicase/translocase subunit XPB</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 3'-5' helicase/translocase XPB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_07621</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 22">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQG3"/>
    <dbReference type="FunCoup" id="A0A194QQG3">
        <property type="interactions" value="1935"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQG3"/>
    <dbReference type="InParanoid" id="A0A194QQG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="330"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="545"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="900" mass="101645" checksum="12E392C532563112" modified="2016-10-05" version="1">MGPPKKFKKYDSKPSSERSGKKKKVEEDITIDLVEDDNTDNVGVPVAATQDAEKNDQVPEDEFGAKDYRNQMTLKPDNTSRPLWVAPNGHIFLEAFSPVYKHAHDFLIAIAEPVCRPQHIHEYKLTAYSLYAAVSVGLQTTDIIEYLQRLSKCSVPAGIIEFIQLCTLSYGKVKLVLKHNRYLVESKHVEVLQKLLKDPVIQQCRLRRDGDDDLFASAVPNKPSTTTASKSVEEKPLTNDTVPEDISQFYQQLDKDDEEDEATDLATNTAVAFEVDPDKIEVIQKRCIELEHPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAVCTVRKRALVLCNSGVSVEQWKQQFKCWSTADDSMICRFTSEAKDKPMGAGILITTYNMITHGQRRSWEAEQTMKWLQAQEWGLVVLDEVHTIPAKMFRRVLTIVHSHAKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQAAGYIARVQCAEVWCPMTPEFYREYLIQKINKKMLLYVMNPSKFRACQFLVKYHEKRGDKTIVFSDNVFALRHYAVKMNKPYIYGPTSQSERIQILQNFKFNPKVNTIFVSKVADTSFDLPEANVLIQISSHGGSRRQEAQRLGRILRAKKGALAEEYNAFFYTLVSQDTLEMAYSRKRQRFLVNQGYSYKVITELKGMDTEPELFYGTREEQGMLLQQVLAASESECEEEREAGGAAGAGRGHVAAPAVWPHSQALTTLSTSSTADNTTNIRSSRSSDINSRTNNKCTHFNSAESESASGVPEWAIVELQGLVQMKKEATAGRTVIGDLHYYQRNRHPVLVLGHHILNGKEVKLEQPMAVIEKVDIDGKLEYKIKAIVKKKLLFKSRPKPIISHVSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRK3</accession>
    <name>A0A194QRK3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ephexin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRK3"/>
    <dbReference type="STRING" id="76193.A0A194QRK3"/>
    <dbReference type="InParanoid" id="A0A194QRK3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11793">
        <property type="entry name" value="SH3_ephexin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="628"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118322" checksum="12EFBD78EC25E729" modified="2016-10-05" version="1">MVSERSPKYGVAPPLPARPRTFRRNCGDQVSVTSPTKVYIETSVKSAHYSANDEQTGRRVRRGLNDDFDDRVTVIKVLEQTCWLCIRTVLQDGEIEIQDLVAFIDGDSSDSGHFYESLEPAPPVPAHPTHMGLVAHDTHVAHTAHAAHGDHASASHMLPLEDDFDSFDSDTDSEDHDQTGPTRTAPEVPSSRLPTPPNGGGPYTLTKIANAAQKKMRQIKRNLTKRYTVAMDGKPFTKASQQNGTYDLSKPKMRSPIYANCERPEPQPNYTNIAFNDSRNLSTKSDNTIAKVGFKEEGKPANGDKRHSNGDVGSPQEKPTTPTNETKKDTGTLSRKTYFSFKSRFRRASSMAVDLNSEVPSALKITNSTFYLTDSMDGDSGFSNCSDSGATNTDTLSASSRRRDGTRAWAESSPCLAPPLERPAQPPPPPPTVPPAPHLPPAPPVPPAPRTPHAPQPPHVPPAPHTPHTPHVPHTDLSAVNEELKRLLPTLSRKDKGPRTRTSWYAECEPAQLTTTPSWYSEAGLYQGNASSSSGASSGSHPASPLPQPHSLFTHEPLYQFYNAAKVESACRESGDSDSDGYEASAVRARPSAMALVAPRGPARTLWCEVPEVLNSAVLSSLAPAQKRLQEAKFEVLTSEASYLNSLNVLEAHFISHPAFRDPHVLPPHDWDTLFSTILPVRKCSQLLMMDLEKCWQENILLQDICDIVRRHAEARFHAYVKYCENQVLMVRALQRLRDRPAFANALKRLESHPACQSLSLHSFLMLPMQRVTRLPLLLDAVLRNLQPADREYDGCMHALATLNDFVSQCNEGARNTERVEEMFRLAAAIEFPSHAHTAPLLGPACSRRDRKPIRWLVRSGEMTQLIWKADELKLTFGKKFHKVPLHLFLFNDLLVVTKKKGEESYLAVDWCTRSLLEVCEGAAAPPSAKHALLLTLLENRDARTVEMVMSCPSETDLSRWSEALAPLQGGAGEAVYAGWDCPQVAALYAYAPAQPDELPLAEGDVVNVTRKTSEGWYYGERTRDGEAGWFPGSYTVEIASAHVRARNLRQRYRLLALSGTYLGHRKRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRW5</accession>
    <name>A0A194QRW5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRW5"/>
    <dbReference type="STRING" id="76193.A0A194QRW5"/>
    <dbReference type="InParanoid" id="A0A194QRW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="301" mass="33218" checksum="B76C4E4FA7CFF8A7" modified="2016-10-05" version="1">MKVIEDEQRVRVMEGPWTPEAVIKEIVEEGGHDEPFYVMDLGEVVARYHHWKELMPRVEPFYAVKCNDDKLLVSTLAALGAGFDCASKAEIEMVTGLGVRPERIIFANPAKLASHIRYSSSVGVDLMTFDSETELVKIKQHMPHAQLVVRIRCDAAAARCPLGIKFGCDPVTEAPRLLKLAAVFGLRVEGTPHSSSFWGPTCDGLDCVVPRMRIPALPLGAWLVFRDMGAYTIPVASSFNGFPVPKVRAVVDRRLWSVLKELWPLTENHFVVAPPAPVAPLAPVAPPPEPHRAVFVECALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS28</accession>
    <name>A0A194QS28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle targeted PIP5K1A-regulated poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS28"/>
    <dbReference type="FunCoup" id="A0A194QS28">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS28"/>
    <dbReference type="KEGG" id="pmac:106720000"/>
    <dbReference type="InParanoid" id="A0A194QS28"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF66">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE TAILOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="396" mass="45777" checksum="1EE43867EEF45826" modified="2016-10-05" version="1">MANNDNILDINNLHLEGDFDSQVRGLMKYIRLTRSEVEQLQILIDDLQWTLEKAWPGCAVHAFGSVVTGLGIKCSDLDCHISVPPWLWSPANVFVYKARAILKKQPHIFKEPFAIGEAKIPIVKFYHIPTHRQCDISFTSSQSIENSKLLAYFMEVDNRVKSLAILIKYWAKVHGLTGTNLIPNYAMILLVVFYLQQKDILPPVHRLQSNEYIVDNWNVAFDDVMHVSGNTETLYELLGGFFLYYRGFNYDKFIISTFLGQPISRESFSIVGNEPPEYRLYRENLQNERCLPLRMDSIICLQDPFDHSRNCTVAVHPKLVKKVMSYIRLCATAYEMEKSDAFLWAILSMRIEESPVTRKIVPRNIVKNKTASKKQKKILHEAFMRARQKGRKKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS84</accession>
    <name>A0A194QS84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine aminopeptidase 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS84"/>
    <dbReference type="STRING" id="76193.A0A194QS84"/>
    <dbReference type="InParanoid" id="A0A194QS84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11417" checksum="D5850560C49E04EC" modified="2016-10-05" version="1">MINEGGWRDEQWPDHWTAVTADGSWSAQLFESSVYLTLDKANATHVLQMAISTSSIGVNKFLKDQLKTIIKNIVVIKSDILLNQVYLKIKGLLVDDWNNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSJ9</accession>
    <name>A0A194QSJ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B14 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_12215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSJ9"/>
    <dbReference type="FunCoup" id="A0A194QSJ9">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSJ9"/>
    <dbReference type="KEGG" id="pmac:106717869"/>
    <dbReference type="InParanoid" id="A0A194QSJ9"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="14">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="14528" checksum="39D85542D0B7EF6D" modified="2016-10-05" version="1">MAAKQAIQVGTKNVRPVLSIDRGEAKARVLNLYKAWYRQIPYVVKEYDMPKSEDQCRAKLKELFLKNKDVTDVRVIDMLVIKGQMELKETVNMWKQKGHIMAYFKPTEEPKPKDFLSKFFSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSP6</accession>
    <name>A0A194QSP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSP6"/>
    <dbReference type="STRING" id="76193.A0A194QSP6"/>
    <dbReference type="InParanoid" id="A0A194QSP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="435"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="651" mass="72066" checksum="56A1419550165D43" modified="2016-10-05" version="1">MALCKVAGVSWMRVAQIDTIVNAYKTLSKIPSIVGAKLNNDGNRISCKWSVRNLDKGKTTKYLHDYILNDNLKVISESEFGVDVSNELLSSVSPKGMFKALIREEKEGKDKKQYLEVWCRHNLAHCIDLTALDVHGDVYADSEFGSLDWSQDESALVYVAEKKLKKSEPYIKRKSEDKAKTDGSGESTPKRLVGKHLSVVVMCKLATETVTVLEGLPETWCPGQVRFSPDGQSVVGVAWETEPRRLGLIFCTNRPSYIFKLTLDGNLNGGRIVDISNKSFIGSTSVLDVKADIVLAACSNMTTPAQLFVARLPAKGSEMEIQWVQVTESSEVPASVARSDVKYIQLQHDTEESLFVARLPAKGSEMEIQWVQVTESSEVPASVARSDVKYIQLQHDTEESVKSFTALYFAPSELDKKFPLIVWPHGGPHTAFVNAFSLEAALFNMLGFASLQINYRGSIGAGDASVRFLLKRVGDADVRDCKLATDEILKQYPVDSTKLCLFGGSHGGFLVTHLSGQYPDTYRVVVSRNPVVDVATMFNSTDIADWCAVEAGFLFTEKGPISEEELLAMRRCSPLAHVHRVKAPTALMLGSGDKRVPHYQGLEYSRRLKANGVPTKVYMYEDNHSLSSLPAEMDNLINSADWFLTHLNKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU78</accession>
    <name>A0A194QU78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU78"/>
    <dbReference type="InParanoid" id="A0A194QU78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="347" mass="38742" checksum="D13D5330A8F88BC6" modified="2016-10-05" version="1">MYQGESSTLTYTVQGEGSPGPRPNKKGSGTPLNSQPTLPEDDQDWFKEQYERKIGTPASCTTPDINVILKNLILKYKGPKESAAYAEPVNPKTEAKLLKWPDMPNIKKCLCRDFGCICRGCKLSEAVSIPYASTTSSKNEPAGTFMGSLEVALIEATESYMLLLSDDRTTCGTKRYFAIEACFLCGHGIAHGAKDVVTPRPLRLMVLQEASVSPHLEEKLRLDEYSYTLKKRRMKRIMKYQQEHAREIEEGLNEVNPKTEAKLLKWPDMPNIKKCLCRDFGCICRGCKLSEAVSIPYASTSSSKNEPAGTFMGSLEVALIEATESYMLLLSDDRTSESNFHTHVQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUG1</accession>
    <name>A0A194QUG1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUG1"/>
    <dbReference type="FunCoup" id="A0A194QUG1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUG1"/>
    <dbReference type="InParanoid" id="A0A194QUG1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="441" mass="47757" checksum="08B404F87FDE2088" modified="2016-10-05" version="1">MTFPGSLPDVAERCGRWAPDSLSASASGSSDEKPTPRRPRWRIALAALVVLAALGAALGLPLALGGGGRATPEQRLVTIRRMLRDSPLIDGHNDLAWNVRKFLHNKINDFNLSAGLEGLEPWARSRWSHTDIPRLRLGQVGAQFWSAYVPCGAKDRDAVQLALEQMDVIKRIVEMNAAHLALVTDASELLDAHREGRIASLIGVEGGHALGDSLAVLRAFYHLGARYLTVTHTCDNRWARAAGTPGGLTEFGRAVVREMNRLGMIVDLSHAGEETALDAIETSRAPVVFSHSGAAAICNSTRNVPDELLRKIAANGGVVMINFYAKLVTCGERATVEDVVAHINHVRKVAGVEHVGLGAGYDGIDAPPEGLEDVSRYPHLLAELLRDPDWSEEDVRKVAGLNVVRVLRHVERVRDEWRRAAVLPGEQAPGARHGECVYGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUY6</accession>
    <name>A0A194QUY6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FCH and double SH3 domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_15270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUY6"/>
    <dbReference type="FunCoup" id="A0A194QUY6">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUY6"/>
    <dbReference type="InParanoid" id="A0A194QUY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051495">
        <property type="term" value="P:positive regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902905">
        <property type="term" value="P:positive regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11761">
        <property type="entry name" value="SH3_FCHSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000107">
        <property type="entry name" value="FCH and double SH3 domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000039">
        <property type="entry name" value="FCH and double SH3 domains protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000033">
        <property type="entry name" value="FCH and double SH3 domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035460">
        <property type="entry name" value="FCHSD_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="66"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="720"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ09129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="852" mass="96111" checksum="2FD6BF2CE86BAE58" modified="2016-10-05" version="1">MRFTEDNSLYCIATFVARESLSPLSRSREARRPTLAKSGPPSREDVEIWKRGSSGKIYLLFQSNYTKFLKNLHTEQIAKLHAKNQHECDLLEDLRTYIIKRSAIEKSYSEALLKISSAYLNKKIPNIPDIKVDGAEEKWNMWNVWRTVLEENEKLARARLAACEVFQQQIADEAKFLRQHKMNVAKKSTDLLAQAHKELQMSVLDVDKTKKLYFDEEHTAHDVRDKAKDIEEKLKKKKGSFFQSITSLQKNSAKVSSRRDQLEEKSTGARNDYLLSISAANAHQNRYFLVELQTCMQNMEASVYEKVSEFLTLMGRTELLTCSATQHSFGKIRDQAQQLTREYNLQCLYLYYPVLKQHIQYEFEPCDNDPIDTVTMEHESVSQTLAQEARRWATRVVRETALVRDATRKLQLYQAMRDAGQKVDPNDPNGPELEVRMDELRSNIRRSETSRAKYEARLECLRTSGAPVDEWLKEIDLLAVQDTLPRSSSLLSVRTDASGAADQPSSDSFYDSDNTEGEAGTSAAATAGTSGHQRTTSDSQNEDEQDEEVDGDLEEDRMRIEQLTVGWDDPTQVNWDESEPEPAAPETTTEAPAAPLYKCTALYSYTAQNPDELSIIENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDVEREQPSSTPGLVTQISFSSVDYTVEGEDADVVVSPDQISVISAPTAKPEEAKVEEAPKAEAPPPEQLPTLGFCFALYDYDAEASDELNLEEGQIIRIVSREAHDVDDGWWRGEVNGVVGNFPSLIVEECDENGEPLSTGEDWTPPSSAPPVFSSPPRTPEAGYDEEGMTTFILSLILFSFLPPLALKQLLSLLLLFRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV02</accession>
    <name>A0A194QV02_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MOG interacting and ectopic P-granules protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_15438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with hda-1, let-418, lin-1, mog-1, mog-4, mog-5, mog-6, pie-1 and unc-98.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV02"/>
    <dbReference type="FunCoup" id="A0A194QV02">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV02"/>
    <dbReference type="InParanoid" id="A0A194QV02"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001612">
        <property type="entry name" value="MEP-1, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF106">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="389"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112866" checksum="D074B44AA3DC47D8" modified="2016-10-05" version="1">MNGGVNGSMEEVMEVSHPTSPKGKQLTSEDNELDNCSETSTSAEIPNTEEGEDSQSESPMENQCNISTEPSPAAPDTESTRSADIENDKFDGENSETEELQHSNVNLDNKETHNNNKAEKESLDEEDTTASTEDKSEDVGLNLDIQNDICDEDSSKENETKVEDTDIEFVENEDNKNDQNGESQDYLILDGEDGLENAEVIIENNIKIPVPENKVQLRRSSRAIKRKRYDDDLENGNDVSDEAVHIEDNLRRKSRPIVISDPKSLVQMAVKQMKGNVSSNQKKETTVVILDTNAITQNKPIPIKNANLLSAHNYMNYVGRGTSITPVSAKTNSSIQSSSSGSAQPLILPSLTDDMFVVEAPSFIVPYVYEKPSIKPFREFVDLLGNELEKQKSKEEKDSAVDKDKLDANKDEKVDEEKSEAEAVTAEAEKGADKEELKEQDEDKEHKEEKKKSKEEKKAEKRKKGNEDDDDASWDGESSTESDDEAGSDDEEKTVVIKDKADLSDELKDVTRLPVDKVVCGKSDNYFDCSLGKFFMDIGLNLVQEFVQNDLLKQQNRKLSREKRAGHNTRATETSIASLMKNLEISQEKNSPYRHKQNKCEFCSFKSESMLVMLHHLETPHMKNSVYKCNYCSFEIRSPHDILYHMEAEHNVRGKLERAPAYHQCANCPFEDNGKGKLARHLLPCSRKFKPETNLAPPIEWEPPAKIPKITRSRNNMMGTYQSAFNRGGMGVRTPIPGGLTPVGAAGAFRARGRSPLLPAPRAALPAPVLRGGAIIRQGSPSLLPTNFAANNKGGKCMQQPSISITPLPRQPLPVLPQPAHQNKGSFVICEICDGYIKDLEQLRNHMQWIHKVKIHPKMIYNRPPLNCQKCQCRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRVYQWKLLNHVARDHNLTLKPAHLSYKCTVCTATFGMYKQFESHVYSAHSVVAKRVMDKSKIPPAKPTNDSLLKPLKINDEITIIPQSAKPASAAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVN3</accession>
    <name>A0A194QVN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurocalcin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVN3"/>
    <dbReference type="FunCoup" id="A0A194QVN3">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVN3"/>
    <dbReference type="KEGG" id="pmac:106717057"/>
    <dbReference type="InParanoid" id="A0A194QVN3"/>
    <dbReference type="OMA" id="RQHTEFN"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="190" mass="21816" checksum="D6D7D5C4EF3648E6" modified="2016-10-05" version="1">MGKQNSKLKPEVLEDLKQNTEFSDAEIQEWYKGFLKDCPNGHLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVSAIYKMVGSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIEGAKSDPSIVRLLQCDPQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVU9</accession>
    <name>A0A194QVU9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">RR48_15231</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Ya'a_city_454_Pm</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVU9"/>
    <dbReference type="FunCoup" id="A0A194QVU9">
        <property type="interactions" value="1446"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVU9"/>
    <dbReference type="InParanoid" id="A0A194QVU9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="600"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="294"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KPJ09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119846" checksum="841DF870B636A73C" modified="2016-10-05" version="1">MLYRPTDLLRLPHGLRNLLIISTYFLVFYYLLLLMDKEESNDVEVSENEDLTRKRKKSKKHKKRRKASVNDDDISAKKRKKSKKEKNKSPKPESETSLSDVEELITKSQHRISNKKSSHSSPVTEKEPIKNKTSKAKNGDAESHKNSKKKANSKSNKYDGLETISSNSGTENYQEDCASPELALIEDDLNLEELMKQKELLQARLVAYYSDKSEDGECKDKVGLGATNNKVICINEESCTPTLEKMPKDRDHDTKLTTKHKSSKDHSSERKSDKHSYKYLKEDLRDVIKREKKVERRTEEWKDAKDQRMRKEMERYTPTYRERERERERKREREREADREREREKERDRERMRRSLAHKKKERDRSSRHSRERYSPAGRRDRRSDYRRSRSRDNRARSRDSKLDYRDRHRVGYKQSSHEATQTIVSSSDEELNISVKTDEEEETEEQIIERRRKQREQLMKRLGGRDNSLSGKLTPPLTEIKQKTPPKEDSTVVSVPKENEVVVTPEPAKSDINTDAKAQDNEDGNNSDNDKTGTSSADEKKSKGWDMFADQDNFHSFDTPTNRETNNKNTIENPSLNDNWDDAEGYYRVRIGETLDNRYSVYGYTGQGVFSNVVRARDLIRGSTDVAVKIIRNNEIMHKTGLRELEMLKKLNDADPEDKYHCLRLFRHFFHKRHLCMVLEPLAMNLREVLKKYGKNSGIHIKAVRSYTQQILLALKLLKKTKILHADIKPDNILVNDTKLVLKLCDFGAASHITDNEITPYLVSRFYRAPEIILGVPYDYGIDMWSTACTIYELSTGRIMFSGKSNNEMLKYFMDLKGKIPNKIAKKGQFKDQHFDANCNFLYHELDKITEREKVVIMSSIKPTRDLQLELAPPHHRLPPAEAKKIAQLKDLLERMLMLDPTKRASFKTMFPADHVFKVRRLYKLILRVHRGMPAELRVLGDNYARDEFKRHKNCNPAEARIFLNEWTDYAISLAQQMKPLQQAKKKAVGKYLDPKMLDFMTEDQLIQLYELHQATLSDSKKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW48</accession>
    <name>A0A194QW48_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosol aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.13.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinylglycine-S-conjugate dipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Leucine aminopeptidase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_15331</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-cysteinylglycine + H2O = L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:28783"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:28784"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-benzyl-L-cysteinylglycine + H2O = S-benzyl-L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145802"/>
            <dbReference type="ChEBI" id="CHEBI:145803"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:62569"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:60444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.13.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60445"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.23" evidence="7"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW48"/>
    <dbReference type="FunCoup" id="A0A194QW48">
        <property type="interactions" value="754"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW48"/>
    <dbReference type="KEGG" id="pmac:106717247"/>
    <dbReference type="InParanoid" id="A0A194QW48"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF25">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="16">
        <location>
            <begin position="52"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="15">
        <location>
            <begin position="216"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ09190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="60095" checksum="3E049E41F2B32E99" modified="2016-10-05" version="1">MYRINVLNLRKRNVFVRFISQFKIQRSDCISKINIQQLRDPKACAIRDKGLVLGVYYNDNVKEESVILTPSAQKYNEACEGKLWKQLKLAPIPRLGEARIFYDLDPQFAYVAVAGLGTECFTFNSLEQLDERKEAIRIAAGTGAKALNALRPTYIHVESFGNAEAAAEGANLAVWQFREYKSILNQNVLPNAKFVLHDNCDVEGWNIGQIKAESQNLARYLQEMPANYLNPTSFAKIAVDLLCELNINVEVKTQGWAASHEMGGFVAIGRSSIQPPLYVEISYYGANELQRPIVLIGKGVTFDSGSLDLKTPKDLKYMKGDMAGAACVLAIIRAASMLKLPVNIRGILPLCELMPNGKTPKFGDLVNSGNGKSILIRLPSREGRLLVADSLVYARNYWPKFIIDIGTMSKELLHTLDGAACGCYTNSEELFCYLELASSQTGDRIWRMPLWKFYEDRIKDTSSADVANTAQHKYGDSPNCAAFLKQFVCDSQWIHLDTYNVAYSKGRDIPYLGRGMTGRPTRTIIEFLFQLIADTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWH6</accession>
    <name>A0A194QWH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWH6"/>
    <dbReference type="STRING" id="76193.A0A194QWH6"/>
    <dbReference type="InParanoid" id="A0A194QWH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF8">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="38176" checksum="63812F1BEEBDBE7E" modified="2016-10-05" version="1">MLKSHFDISQRSEAEEEEEVEEEEEAVRSESSVSEETKKVTVLKTKPTIAERKLNRSEVSVRQSLLGKTADGDGYAFLKATCTGMRLTDIRAIASFKHIQFVDVSDNFLTTEALQVVTKIPFLVLIHADKNQLESAYLKKCKYLQVIIMNNNSISSVHDVYHPELSTLEVGYNEIEKIDFRDRMPTLRCLDFRHNRISDISKLNFPNLDSLYLAGNKITSLVGIESLINLRILHVRNNPIKLLNGFNADQTKLQYINLRNCKVTTMTQVKKLQCLPALEIIVLKGCPFMGGSGEEGNEVEEDDSELRIEVLAALPRLKRLNKGIFTPEERQDTFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXI1</accession>
    <name>A0A194QXI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative odorant-binding protein A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXI1"/>
    <dbReference type="KEGG" id="pmac:106716592"/>
    <dbReference type="InParanoid" id="A0A194QXI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A10/PebIII"/>
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    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264712" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="14584" checksum="69FEE66C03262CB8" modified="2016-10-05" version="1">MQLIVLVFLVFPLFISAEDKYYDRRYDYYDLDNLFQNPRLLRKYMNCFLDKGPCTPVGRVFKQLLPEVVMSACAKCSPSQRRLARNTFEAFDKYLADSRDELKRKLDPQNVYFEKFLKAISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXJ0</accession>
    <name>A0A194QXJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein shuttle craft</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_13030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXJ0"/>
    <dbReference type="FunCoup" id="A0A194QXJ0">
        <property type="interactions" value="2384"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXJ0"/>
    <dbReference type="InParanoid" id="A0A194QXJ0"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02643">
        <property type="entry name" value="R3H_NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034076">
        <property type="entry name" value="R3H_NF-X1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="423"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="426"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1195" mass="133401" checksum="004EAAD133E51D33" modified="2016-10-05" version="1">MSQWNNSYGYNNQFQAPPNSWNRDVNGQYVNQPYYDNRQYESSNQYVSFDEFLTQMQGNGVPQNNASNYNNVQYQAYPTNQYNYQNVPSQNPQMEFSYGHHNPNTSSTLDTYTVNVQNQYNPSVPELSTYSNEVVMNSKLTPTATEFVPKCSINVASTSQNTSQETSVTNDVPANKSGKSSETNWRERPSNNETVNSQVETNNFNRYQKNYKNTEGNRNRESNSRYENKRNNETNQESNGRYRNGHSSNSNQSNPQNKESSNQNKEPENSANDSSNHQNENHRNFETGNRNETRKYANENNQSKSNSKAKNKDSDAGRTFYNSSINKNSQDVRNGRGEGSGRNRNWIGSQRLRTTERNIVEDEQYANTYMHYKDDRAERIANNNKHEKTASPVKGRSKPTNDSGGNTAMTQRERLTEQLDKGTLECLVCCERVKQTDSVWWCSNCYHVLHLRCIRKWAMSSLVEGKWRCPACQNTNEEIPTEYRCMCGAVKSPEYSRGSVSAHTCGKSCRRPRNCPHPCTLPCHPGPCPPCQATVSKQCGCGAETRSVLCSSKLAQLCGRECRRKLTCGVHECQRECHEGPCDECSEIVTQVCYCPAAKTRSVPCTSDTSGEHAWSCGAACARVLSCGAHVCRRVCHAPPCALCPLRPDNVHSCPCGNTKIEKDQRKSCTDPIPLCGNICAKPLPCGPEGDKHFCKQFCHEGPCPTCPDKTLLPCRCGHSSREVPCSDLPDMLNNVFCQKKCNKKLSCGRHRCRTACCAAQSHRCAVVCGRTLSCQLHRCEEFCHTGHCAPCPRVSFEELHCECGMEVLLPPIRCGTRPPVCQAPCRRERPCHHPPHHSCHTGDCPPCVVLTTKMCHGRHEERKTIPCSQEEFSCGLPCGKPLPCGKHTCTKTCHKGQCDTDKCKQACTEKRASCGHPCAAPCHVDNGGVCPSAAPCRRLVRATCACARRTADRPCHENARDYAKMMSALAATKMQEGGSVDISEVHRPGAMLKTLECDDECRMEARSRQLALALQIRNPDVSAKLAPRYSEHVRTTAVREPAFAQNVHDCLTELVQRAKKSKQKTRAHSFPSMNRQKRQFIHELCEHFGCESVAYDAEPNRNVVATADREKSWLPAMSVLEVLAREAGKRRVPGPVLRAPAAPPPTPALATPTTSTSRSTGGWATLTSTNAWAARSQPARVEPKIDYFDNPPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXK6</accession>
    <name>A0A194QXK6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXK6"/>
    <dbReference type="InParanoid" id="A0A194QXK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="239" mass="26466" checksum="B1D37D3744B7630B" modified="2016-10-05" version="1">MPKLCSFGCAFSGVPMHRFPHADKFPERFRAWVNLVGGKLETPVDYDYYSKKLVCDIHFTVRDRNRNKRLNALAVPSLHLHGTSDSSILGPSLVDVGNQPSTSHHFNTGTPGSSTLGPSTVDVGIFSTVHRSFTIIKILVIGGASYEVETSESVIDSRVLDPISLEVRWATRYTSRCEGGKGRRERGRRAPSPRRDVSAAATDRSQRLSTDCAKHSRAARAHIPDTNDSRDGIRYMAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXR0</accession>
    <name>A0A194QXR0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein toll</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXR0"/>
    <dbReference type="STRING" id="76193.A0A194QXR0"/>
    <dbReference type="InParanoid" id="A0A194QXR0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264719" evidence="4">
        <location>
            <begin position="21"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="806" mass="93982" checksum="B07F6D2A10E1AC97" modified="2016-10-05" version="1">MARNIVYWLLVVLSLEAIDAKRATCPGYPNCICGGTLAVEVDCIVSGQTVKIDVLPGVYVNIKCENSTFLNYNKLPNFNNRRNNFKTVSFKNCPLPSNSFKEVLTNIGVNKTMSLIYQNDKNISQNFKRNHFVGLEDLNKLLISVNGVIFLPDNLFMDLNNLKWLNLRMKSVNISEELFKPLRRLDTLEINHNQMTNMPNNVFEHLIGLKKFSLWQSNISIISHDFFKGVGELEELDLSSNDLSKLPSGTFNPLKNLKKLTLFSNKFSVLPENLFAQNKLLSTLIILNNDVKIKELPKNLLRNLQYLKQVHIQRCGIEIIYNNLFTNSSRINNISLAHNEIKNLPEAVFNDQINLLELDISYNNLENLGIKLFSSLVRLERLNLCCNSITEISGLTFLPLISLIYLNMESNHLKVISSNLFENNRQRLSISFAYNELDFENKILVNNSWIIRRNSPFINTHNLQMLNLSHNKFRDVFIDWWVNGHEHIDLRFNFIKNLWGDGEHEFSHNYKIIKTPIKEIWIGNNNLSCGCHNLWFIDYIQAHWKTKISDMDFKHCPMWSTRVVCYIAFYVIISITAILFCIAAFVIIAYFIYKKKFHELLKRICSNVYHDNFKKEENKIAVKYSIADEEFVLKEIVPGLQDIKNVKLLMKPISDLNTKKSFMKILKRNESEKYVTVVIFSPNYLMTTYSKVNIKKIRGEMLKARNTIYIFVDTGPDNSIYAFLKDQRETRVSVLWNEVYFWDKIIDFVSKYSRHRKFGHNDTNGQGKNNLVKKINKVKYTPKMSFMKLSEWPQTDTFETFAHSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXU7</accession>
    <name>A0A194QXU7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_12154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXU7"/>
    <dbReference type="STRING" id="76193.A0A194QXU7"/>
    <dbReference type="KEGG" id="pmac:106717698"/>
    <dbReference type="InParanoid" id="A0A194QXU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="12405" checksum="EA03DB8124CD0ACE" modified="2016-10-05" version="1">MSLPFGRPQTVSPLIRGLRYGLLIAGIFYGRYKQAKYEELEDIWREEEAKRKVLRDKELKILKARIAKEEREVIRQIETGEYFKIVSEEEVKPEETKPKECRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXV3</accession>
    <name>A0A194QXV3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXV3"/>
    <dbReference type="InParanoid" id="A0A194QXV3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="288" mass="33366" checksum="78781149A0656AF4" modified="2016-10-05" version="1">MALATKVQNVSEAYLFMKLYETVKINGAVQDNLSVRHDRHLPALFQFFRGLRGEENYHHNIQPYYFLPSVLVLPINQQQNTIIQESSGQENYQEISKSLQMKNYAKLISSEKNIDINETFAFNRTVYVKNSNLENMTNEDSKLTLMDNVTERVTTNEIATVICENANTEISTEAFGRYPPAKNNSNFLNSLSLTTDNIEKYENYTNPNSYQEHSELKKNLFDSKHIQTIENHLLPPFEKPLFNTFKPNISEYNDYLPLDDNRWQQFSTQKKDILAVKGFKPLAGKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZA5</accession>
    <name>A0A194QZA5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G patch domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZA5"/>
    <dbReference type="FunCoup" id="A0A194QZA5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZA5"/>
    <dbReference type="InParanoid" id="A0A194QZA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="42438" checksum="EEFBF86D714AF48D" modified="2016-10-05" version="1">MDFARKQLEKYGWSAGKGLGKHENGISEALKPKLKRSVAGVGHDPAADFTEHWWNDLYNKAAKNLEVENKNGKTRRIKRKNSSDFEITNNTWQIKKNKKGEKSDQGYTDFFVKTAILNNGESKVENVKECDSENEKTVRDIFKMTDEELFAACEGRTAHKGARHGLKALGKLARIEQQEQLLLNQDKYKGYSHTKKGKSIDQEVKINDQIEETNSLEIDTDSMPVKKKKKKRNKDIEEKESQTNSNEIHAKDDDQLETFKGNEKEMEASYQPADDDNVDVKKKKKRKNYEVQKDVQSKKEKDNSDDASDTALAGAAAGAGARVLASAYSQWRSSYECHCTCDRSFSNFATYLEDMDEDLFLLMENVADVCFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZB5</accession>
    <name>A0A194QZB5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Synaptic vesicle glycoprotein 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZB5"/>
    <dbReference type="STRING" id="76193.A0A194QZB5"/>
    <dbReference type="InParanoid" id="A0A194QZB5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="645"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="99"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="671" mass="72314" checksum="D34519D61A005248" modified="2016-10-05" version="1">MAEEQACLVRARSDSESSSKLGSFGSITRTMTYTEDRLTGAEGAGEPGNVSAPTASPPEQVPDGNESGELLDYNDSSVLEQFHEDALRQAGCGLSQVRVLLAVTLAIAGASLELAAIPFVLPSAEIELCILPHEKNWLVLISLVGGSLGAVGWGALGERLGRRRTLLSCLAVNAVFAAIAAFMPTYGTFMMARFCSSIGSGGTASVGYTYCGEWCARARRRRALALLAAGAGAGALLAAALAHAVLPDTGADALRENKEHFSAWHRYLLLCTLPILASLVSLIWTQESPRYLLDVGREVDAMMVYQLISMSMYVCMVWCGVVQSIHSSNQFRVCGKVEVSAGAGDAEYRLGELTLPGKRRPPALHHVRHSVKMFWQAFFQLFSSPYRSTTISLGGILLFSMAIQYYLSSYVPATVVSAESEQFDAAKRWITNESFINEHYNETLENAQFVGVAFRDCNFRDMIISHVTFQNCTFTNVSFSNIMSSFTMFKDSVFINSSIIDTDMEVGRELSECVLSGSVVRGIRGGCARHADLRSHLAGLRAEQAHAARAALAGAALALLPHPTTVRPTVILCAACIVVSPSIYFTRDETMLYIIEAVYRLLVTLIFYNVGLDVVNSYPANLRCTAHGLILSVAYMGGAIVKGAGEACASLSTLLCALLALAATALSLYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZK6</accession>
    <name>A0A194QZK6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Fibroblast growth factor receptor</fullName>
            <ecNumber evidence="19">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">RR48_07725</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Ya'a_city_454_Pm</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="19"/>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZK6"/>
    <dbReference type="FunCoup" id="A0A194QZK6">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZK6"/>
    <dbReference type="InParanoid" id="A0A194QZK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FGF_rcpt_fam"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000628">
        <property type="entry name" value="FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 19 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="180"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="354"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="596"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="602"/>
            <end position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="678"/>
            <end position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="300"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KPJ10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="912" mass="103387" checksum="6102E51BD5EC1153" modified="2016-10-05" version="1">MRGDHKNDTYTVIQASTNERLRLVCGLRPRSQTQGVRWHFDGKPLEGQNKPRIVLQRQWLRIKGFRAKDAGVYTCHNDEEKGREMSVTIKHKPDVEQDNLEEYQSDMDMQRPMPEILAQHEAAPLVENNTLDEKPTDVKRLTKSLKYREYDIKDEDIDDKSEKEHPNYGHVDDTKTKYAPKFKHPSKMFNMDMKPAGSSIRLKCAADGNPTPNITWFKNNGTPIMRTYFQPSYGKWSMTLDELTKADNGNYTCLVCNELGCINHTVILHIQERYPSKPYIKEGYPGNVTVLVNDTVKLSCPPVSDLEPYSYWIRPSNYSLKDAEVGPSDAPIPAGDVIEVHIFKFGGERLYAKPVLTQGVVNQTKLVGETAKLSCEFLSDLHPYVFWMFFTNDEYNYNVTIDTNDGATQESIVFYDTTKLMTSEDPSDKPEQLTIFNVTKEDEGWYVCVALNTLGNTTAKGYLSVVESFPAPEPINHGKHTLFINILTAVLGAMFLVAALVVVMVFKKLKREKIKKQLAIETARAVIVTHWTKKVTVEKPQMNGTPSTTGEGLLMPVVKIEKQKLSQVQGNTSDSMMMSEYELPVDIDWEVPRESLSLGKILGEGEFGKVVKAECVGILKPGVQSVVAVKMLKEGHTDAEMMALVSEMEMMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRYESPTEDLKEKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDLAARNVLVSDDCVLKIADFGLAKDVHSNDYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMYQHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDLDKILTVTANQEYLDLGLPQLDTPPSSYDGSGDESDSEFPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0T0</accession>
    <name>A0A194R0T0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein prune-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0T0"/>
    <dbReference type="FunCoup" id="A0A194R0T0">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R0T0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF22">
        <property type="entry name" value="MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="394"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="554" mass="62631" checksum="4C1FF69AC6537F69" modified="2016-10-05" version="1">MSKLTFSTQSESPRPKNLGISPPRLNSKLTLTTNHPLMTLGSPEENFPDLIPKTANKVGDEKDLSLSSVEDERIQNQTNGYEFYSLQMNTSKNNLFYSENFVPTDNKLLSESLNVTQPDVARIEDLDKIERLKISKNDAPRNMLTPKSNQKVPDGENDSAIFKYIKERNKIISSQSTPKCNSGPVDVSQPVISAVADWCESPSMLRSIPNFELPIEMSSTIGIHNVADWCESPSMLRSIPNFELPIEMSSTIGIHNDLDSPDVISSSTQEDKSAYQALLDPYTGCVALRQRTDTKANSRPMRRKIFVPPDDDRISSDSVSACSLESEDEPPEPEPIAVDQAQADSEIDDAKRSKSTNTVSECSDPIPEYSAAEELQDERSWLTVQHGGRNSTCDMKVIEPYKRVLSHGGYEASGAAIIVFSACHLPDTARTDYRYVMDNLFLYVIWSLERLVTDEYVLVYLHGSAGRRRLPTFAWLHECYKLIDRRLRKSLKHLYLVHPTFWLKSFVVITKPFVSSKFFRKLSYVRNLSELMERVPVEPNAIPDLVKQYDATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0U5</accession>
    <name>A0A194R0U5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0U5"/>
    <dbReference type="STRING" id="76193.A0A194R0U5"/>
    <dbReference type="InParanoid" id="A0A194R0U5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="533" mass="58187" checksum="F82E0283B8DCC5A5" modified="2016-10-05" version="1">MADIGVAIDGGKDSLSMCANVAGQTVRSPGTLVVSTYAPCPDITVKIEPALLQQGSALIHVPVTPGKYRIGGSSLAQCYKQLGDNPPDLDNPATLKALFKTTQKLLKEKKLLSGHDISEGGFITTVLEMGIGGIRGLNIDLLVEKGVSVIDSLFNEELGIVVEVAQNDVDYVLNEYKKNGVIAKVVGTTGKYGMQSEVVVKVNGDCVLNTTLVKVYRMWEETSYQLECLQANTDCVTQEWLGLEKRKGIKYNVTFDPAAAVVKSNSVKVAVIREEGTNGDREMIASLMMANFEVFDVTMSDLQAKKITLDAFKGLVFPGGFSYADTLGSAKGWAAGILFSENLHAQFAHFKNREDTFSLGVCNGCQLMAWQCWVDVDDSKNFANKTQIFLDHNLSERFECRWSAVKITERSDDVWFRGMGGSVVGVWVAHGEGRFALAEPSLLQRLKDNGQLAMQYVDDDGAPTEAYPMNPNGSPEGIAGVRSRDGRHVAMMPHPERCVLRWQCPAPPPAANTQASPWLRLFQNAYIWAANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1H5</accession>
    <name>A0A194R1H5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 46 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1H5"/>
    <dbReference type="KEGG" id="pmac:106716794"/>
    <dbReference type="InParanoid" id="A0A194R1H5"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="522" mass="58621" checksum="C6D007BFF0D71BC3" modified="2016-10-05" version="1">MSASTENINSSVDFTKSNIHLTGDRDETTWREKSKRILKDIKYCIRETTVEPCLFTFMLCTALSSLAVQNMHLEKSCRVNFQYSDEICDRIRDRNTTGLEKELNNVQSLVAKVVAWKFPLQTAIPAVMVLFIGAWSDKTKKRKIFILFPFIGEIVANIGLLLATYYFKELSLTATALIEALPAAFTGSYIIIFMGMYSFMADRTTIEERTFRLGVVTICVSLGTPTGTALSGILLRILGYYGMFSLLLVLHTFSFLYGVFRLEDILPPDDKCAITSDTNDRDKLKKIFKEVFMLVADTVLVALRPRAFGMRTQIISVIVLYILMVGPLYGDSQVSYLYAIRKFNFNEVEFSIYGAVNTVLGLIGTFFCIAFLSKKLDVQDSIIGVMAGVSRIASCFVFAFAPNRQWYYSAPIFNIFSHTGLTAVRAIATKSVPTEEIAKLSSLMGVTEAIAPSIYMPTSSYIYVSTIESFPGAFYLFDASLTLFALALFTVIYILVKRRNQKAVTDPTRKEAYARTNEVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1I1</accession>
    <name>A0A194R1I1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRAF-type zinc finger domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1I1"/>
    <dbReference type="STRING" id="76193.A0A194R1I1"/>
    <dbReference type="InParanoid" id="A0A194R1I1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051986">
        <property type="entry name" value="Innate_Immune_Apopt_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295:SF10">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295">
        <property type="entry name" value="TRAF-TYPE ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="613" mass="67930" checksum="EDC8D7DD65E76403" modified="2016-10-05" version="1">MDEEIKICENCNREIPVVNYTIHSVHCARNIRMCPVCKEPVPIAELEEHTEKLHKLLPCKQCGEKVRGTDMEDHIRDSCDRTIQSCRWCELELSRRELPLHEGYCGTRTEECEQCGEFIMHKYRQLHLDSNHGFVRLDDDPIPRVNRQRPAASTATASASGSGMTSYQRPADRLSRFLDLPDRPPIVGPELTRLFNTITEANTKIDNLHTARESPRSPDASPNQGSNYDGRNFNQWRQNVNLNLPRNNNAQVNAPGVPGTSNHFKPAPRGAIKKRKAPKPPNPKTPESKPDQSQQHAGRMYSLFPPSTSTSTPNTPISNSIPSATSRPMPGPICGPIRGPKPGPNDPFSGPYNRRNFTPLSPNDNAPGSANTNGRLPEATSSEEQKRREFIKAVPVKLTAQKSEIERNPNEEVNKAEDFRNVKPMSTEEFMKRFRELQLDNSKREENSPRERFSGREENSPRGNVPGRLESSPPERFFRREDSSPDSFFTPTPGDRFNAIKSSLKELRRGLNEVTAPYNNNNNNANERGNASRENPAVAMSGSSNSDSDSDGSEAAGGGKSPRGDEAAGGDLAAGGEEGACALDIINVKLPCEFCGTLIQANDLVQHQVIVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1I6</accession>
    <name>A0A194R1I6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1I6"/>
    <dbReference type="STRING" id="76193.A0A194R1I6"/>
    <dbReference type="InParanoid" id="A0A194R1I6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219:SF3">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="19468" checksum="0E580E31FA20C2D9" modified="2016-10-05" version="1">MESTPICRCRVLYLGSAVPQQSKDGLQGIQEPLRELYPEKGATGGGIDSWLSVWSNGILLENVDESGSRVARFFPISSLHYCAAVRRVSVEGAPRFLPLDSPFARAPAPRRPPLFAAVLRRTQGIKVLECHAFICRREAAANALIDGYLFEGSFGTAQRILMIFGTDVEHNLEEHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1R5</accession>
    <name>A0A194R1R5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1R5"/>
    <dbReference type="InParanoid" id="A0A194R1R5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="20552" checksum="ABF3A83ABFF41CC1" modified="2016-10-05" version="1">MSQNWVSDDQFGGVSCRARWLGAGVWARRAGSLGGCARGAEHSAGRVRGGALARPRRRRRVWSVTPPARLATHARARTDTKQHARDARLRRAAARTSLPRRRCSRTLHEALVPCTDPALLNLCSPISSPNAECDPRGRRGFSVPSLDALKFRVSERGERSPAAGLTALFSKYVRHDPVDRARAIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1Y3</accession>
    <name>A0A194R1Y3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1Y3"/>
    <dbReference type="KEGG" id="pmac:106714367"/>
    <dbReference type="InParanoid" id="A0A194R1Y3"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF1">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264857" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="78"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="259" mass="29054" checksum="2CEC825AD1563E3C" modified="2016-10-05" version="1">MKTKVVEVIFHLLLCATVIPGSTYNENYAQNYKRDIAMDVTDFSVYYDVHTNETIRKMMPRPWYRPGWRLRLPFTGGPCECKSYKCTCCTGIRIEAFGFDRRTCAILKFEPEEAIINLEVKISNNSVLVQMFSASNPPPFCVPIPVPYLPPGLVDMCIRLFDVSIVQQKLHVCMDMDTRIDMAPVLILHFDCMDMGIDGVSLSKPGGGGSNPANAATNGDTSESMEPTQVNGDVYDPVTEDPNIETTPQPMFKNSIRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R246</accession>
    <name>A0A194R246_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R246"/>
    <dbReference type="STRING" id="76193.A0A194R246"/>
    <dbReference type="InParanoid" id="A0A194R246"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007615">
        <property type="term" value="P:anesthesia-resistant memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001661">
        <property type="term" value="P:conditioned taste aversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007619">
        <property type="term" value="P:courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046958">
        <property type="term" value="P:nonassociative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008355">
        <property type="term" value="P:olfactory learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007614">
        <property type="term" value="P:short-term memory"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040040">
        <property type="term" value="P:thermosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="127"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="500" mass="56331" checksum="48DFFC4D36A439FA" modified="2016-10-05" version="1">MRVCSERQCVRCAPARWLGRRASKMAHSMDILHLQFKRMLNKELSHFSESSKSGNQISEYICSTFLDKQQELDLPSLQVEENTERTKKKEKPRHGGPGGTMSQISGVKRTLTHTNSFTGERVPRYGVETPHEEELGRLLGELDRWGVDIFRIGDLTCGRPLTAVAYAAFTSRELLNTLQIPARTFIAFVVTLEEHYVRDNPFHNSLHAADVTQSTNVLLNTPALDAVFTPIEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDGCDIFVNLHKKQRQTLRKMVIDMVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFQQGDREREQGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPAPVSASHSGADDDRPEQIRFQVTLEEGEGSEECEGDGDGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3H1</accession>
    <name>A0A194R3H1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab3 GTPase-activating protein regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R3H1">
        <property type="interactions" value="1269"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3H1"/>
    <dbReference type="InParanoid" id="A0A194R3H1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="6">
        <location>
            <begin position="675"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146321" checksum="B7E095653B268F1A" modified="2016-10-05" version="1">MCTVEQIADCGDILSLGRSLFIPEKEDKNWLSQCSVSLSPCGNLLAVGFKNRLCLLTTQWISAIESNTFIISWSGTLPAEISAVLALSICPSYHSSQSGPDWFCIIVGFTNGSIGFYTNTGHLLLLEKLDDKPVMKISCHTGTYGTLPDDIHILFQGCICILSGSSLFQTLRNAKAQLARVQAGVQSDYAVDSRSINIRKWSFTEQELISDASVVGLELKNTFDHFLAASTYGGYDTWYRSIPPVNSLILTVGTSPYAGFHYALEGGTTPPLQDVARAVANKIKSALPGWLGGGSTENMVANPDPIIRSEALSMRNGIYDSQRLGTFVAISSDRRLAALTDNLGRVAVLDVNSGYIIRLFKGYRDAQCAFVQIFDTDSKKPQLTSIKEIRRAIFLIIYNPKKGLIDIRLMQRGTRVAVFTATKNGQLLYNSCEGEHLQRSKDLHVLREIREIMKSAQLLSEESKKEIIQKASNLKTLEIRKHCMDLFIRNMNMPSDVLTSCLEIFWEGVEKESLNSQVQETKNYFAKLVLLIFFFRNINDDACDGMEGIVEKVCEDFKLTHTKNETNKEVEISQTFRLLEDDSCILERLLILAQENNFKEHQPRVSFVDNNTSSYKEFMSYFVFNKTSKVITLKPDIVAEKLDNLAANIFKSILKLKDFSNLTNVVRECHIDSKEIVKLLITHVMNMSLDEINIELIEKIIEILFYLCKVTEDATNINYNDISPWWQSIRDMLVEMRCPLRSMIVAMSCKSVASLFEGNTTGREDAWESVTKENAKWGLLIGKLEDISILSITLMFKGTFKGKTLPKLPVEDFNINLKYIYTRGKGSVTELISKWLCSMGVLPEAIIANELIDLYSETDVDTDDESSESTQLFLENSRAYVDDNQSLFKWLSLLRRQFPLSTLADYIIANMCWEYAINWQKSMQANENIKAVLHCLKHISNLHLRLGLFSIIWSTYIKHCFELSCRLVNKVGKLPKDHLCLQDLGFNSEHLKSFLQVVTQFLHDFHVCSTTAIGQEKKVIKYEKIWDESMPSLVEVAQDVKNVDNDILNLNYQISCTIYYQCHFNVKFPKALDALFDMDYQYLIEALVGNIAQRDINMKPSGKMINPRMKFLTKLIRAAVDTITCVNSDEANLLYNNDDCLLWMENISSLAELWNVNENFVKHQYVVGLYHMGYDTLAQTVVGSVADPEMLLVPIIAITIQRLKRNLEKCKNQPEWIVTVPPQLYKRLQNTTLDVSIPANPSLTTTMIILQKLLSQVDKKLSTETSTNFQNINLAELIVETCEVLIRRNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3M9</accession>
    <name>A0A194R3M9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3M9"/>
    <dbReference type="STRING" id="76193.A0A194R3M9"/>
    <dbReference type="KEGG" id="pmac:106714238"/>
    <dbReference type="InParanoid" id="A0A194R3M9"/>
    <dbReference type="OMA" id="GNDCRVE"/>
    <dbReference type="OrthoDB" id="8190314at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="13761" checksum="20848481963E3170" modified="2016-10-05" version="1">MKKYSVLGNKKKVTMEINATRLKVVGNNCIVRVTTNRGDIEVIGNDCRVEVNDNYGVINLVGGNGVVTISKRWRGDKVQLVGPNCHTLVDGKEKPQQFYEAQLSPFSKDLDDVIDSIFTFVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4C9</accession>
    <name>A0A194R4C9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4C9"/>
    <dbReference type="STRING" id="76193.A0A194R4C9"/>
    <dbReference type="InParanoid" id="A0A194R4C9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="231" mass="26070" checksum="3B2762877F8E2A58" modified="2016-10-05" version="1">MTLPETFDAREKWSNCPSIRKIYNQKCCGSCWMFGTATTATDRNCIHANTNKDLSEQDLSCCSDCYEGELCSGGHPDKAFDFWINNGLVSYNCQPYNDFALENHEYCSQNCLNGADYNQDKNYGGRVYSVPSDENQIKAELVTNGPIEAVFVVYSDIEDYTHGVYIHSYGERKGLHSVRVIGYGEEDGTKYWLVANSWGTRKGLNGIYKMKQFQPEIGLEDNLLAAMPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R641</accession>
    <name>A0A194R641_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R641"/>
    <dbReference type="FunCoup" id="A0A194R641">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R641"/>
    <dbReference type="InParanoid" id="A0A194R641"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="286" mass="31406" checksum="69FF3609B8AF1C61" modified="2016-10-05" version="1">MQSSIKNIITSLCLSAVEHMLSPIPSTVCGPLLFRIQQFPATRSRAMDIISEKFMNNVYVNKNSLENQIRCILNDYPVVENETLKPWLLQIISVIDLTTLSGDDTRSNVIRLCQKAANPLKCDLLNKLGIDNNKLKTAAVCVYPARVPDAYDIIKQMGLTDTIQIASAILITQVYKASMISMSAGADFIKTSTGKESVNATLPVGLVMCRAIRNFYQLTGVKVGLKPAGGIKTARDAINWLVLVYTELGPEWITPDLFRIGASSLLDVVEKSLDNCTKVAPKGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7D6</accession>
    <name>A0A194R7D6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7D6"/>
    <dbReference type="STRING" id="76193.A0A194R7D6"/>
    <dbReference type="InParanoid" id="A0A194R7D6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9647" checksum="50DD89C90D586A52" modified="2016-10-05" version="1">MTDKVIKKTKPSEPSALGKLYLLSYNVIQTIGWFYLLWQSLVHFLNRGTLATYWDEVKWTIIIFQNAAILEERLYLITYACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7G3</accession>
    <name>A0A194R7G3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stromal cell-derived factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7G3"/>
    <dbReference type="FunCoup" id="A0A194R7G3">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7G3"/>
    <dbReference type="InParanoid" id="A0A194R7G3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264972" evidence="3">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="23564" checksum="E2B421B8666B71D0" modified="2016-10-05" version="1">MQLILLFVSVYLLQISSASKAEFVTCGTILKLVNTDLKLRLHSHDVKYGSGSGQQSVTAVDVSDDNNSHWLVKPIMGETCKRGAPIKCNTNIRLQHVSTKKNLHSHYFSSPLSGNQEVSCYGDDDGEGDSGDNWTVVCNNDYWRRDTPVKLKHVDTAVYLAGSGRTFGRPISGQGEIVGVSSQYGTYTDWQAKEGLFIHPGDLLPHQNAIHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8J4</accession>
    <name>A0A194R8J4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8J4"/>
    <dbReference type="FunCoup" id="A0A194R8J4">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8J4"/>
    <dbReference type="InParanoid" id="A0A194R8J4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="498" mass="58750" checksum="F3802BFE32A9F4BE" modified="2016-10-05" version="1">MLKIQYKRKENELDTELLELTGKVLMSNPDINTLWNIRREIFLHIRKDYSEEDLTKMYDDELSITQYCLKKNPKSYCAWHQRMWVLTTRSDPDWKNELDLCNTYLKLDERNFHTWNYRRFVVSQCKPPLQDEFDYTTEKLLDNFSNYSAWHYRSKMLLQLYPDVEGGRPIQDIHHKHELKMVINAAFTDPDDTSAWFYQRWLLGAVKTSINLVACAVSESKITVAFSKPVSLGYVQSSTQIFINNNVLNGEWISCCGYQYDSLWILKQKVDLMGDMDIKAEYEDENKERIVIKCMKYKEKMYIGKGKISFENKYSQPVVEELNDQLKSCRQLLALEPDNKWTLLTTTVFLHCIDAKLNHKETINNLEILKKLDHQRAGYYSDLISKWCIEEQLPIDYCLNSMVFKVKTSDKITCLPHLQYYSFCEEVDLSDQNLCSNVLPSLILLQHCKILILRNNKLVTLKGFPNIDLEKLDIQGNDGINVEELKQFKQDHKFVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8M9</accession>
    <name>A0A194R8M9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium channel protein Nach</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8M9"/>
    <dbReference type="FunCoup" id="A0A194R8M9">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R8M9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="763" mass="87351" checksum="4D211B1105CE1438" modified="2016-10-05" version="1">MSSTGFTGQQQQQNLKQELQNELTAASQNLWELHAQILQLKEFTKPGGELEASIIQFIIIDVLSSRSSSVGHVDNDLEKSHDTPQIKRGKRFTIKEYLIDYTANSNLHGLKSSSVGHVDNDLEKSHDTPQIKRGKRFTIKEYLIDYTANSNLHGLKYIGEKERTPAEKLFWLFMFICCVVLCAGLIRKVWIKWNESPVIVSFAENSTPVWQIPYPAVTVCFETKSLQTRFNFTKYYHLYKDNETYMELTEEERNMFEDITLVCDDHLAPARGRKFSDGYATVENLKQVSPNISEFFFGCKWKDTPKDNCANLFSPILTEDGVCYTFNTLHKEYQYLESTIINSTSDNVQRWSLEEGYPPSAPLETYPHRGSGYGAKAGLTFLLQTKAIDLDYLCKGPVQGFKILLHNPAELPRLSQQYFRSPLSQEVVVAVRPKMMTTSDGLKPYLPSVQVLTLLNEHITDKLRQCYFPSERYLRYYKVYTQANCEVECLTNFTYARCGCVHFGMPRELNAETWTIFVKDLCKASRRQCYFPSERYLRYYKVYTQANCEVECLTNFTYARCGCVHFGMPHGPDMTVCNAGSVACIKKSQMELVTVAIESRLEEETNENDTLGVAKEVASRCRCLPACTSIEYEAETSQADYDWKALYTAFNITIGEDILDQKFARVMIFFKEAQFITSRRSELYGQTDFLANCGGLLGLFMGFSILSVAEILYFLTLRSLRLRLLVQSAARPCHAMTDGDVEAAQRRNEYTPRRCLDVASSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8V6</accession>
    <name>A0A194R8V6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8V6"/>
    <dbReference type="KEGG" id="pmac:106713697"/>
    <dbReference type="InParanoid" id="A0A194R8V6"/>
    <dbReference type="OrthoDB" id="8250201at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="26721" checksum="D15A93EA3568DD64" modified="2016-10-05" version="1">MSKLDDLFDKKKDEAPMLDLSKTTINTAEEYRAVLDKVPEFKTRPEKVRAEDIKIKDRKEDQKTKTPKKEIRAYEKLGTRGYEDKHFTFMDPVPVEMRELKFEELCSVPIEWRMLTSIRPKSKLDEEYFNRLIELRKSELKTKARDKREYAKNNMVKKTKNRSGVTETRILSCVECGEEYCNGMMCAITNYDMFARLKLEIEPKVTRHDHLEEPSTFATKRIYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9I0</accession>
    <name>A0A194R9I0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immunoglobulin superfamily DCC subclass member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9I0"/>
    <dbReference type="FunCoup" id="A0A194R9I0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9I0"/>
    <dbReference type="InParanoid" id="A0A194R9I0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF6">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 7, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="120"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="28778" checksum="93FC3074F400F5BF" modified="2016-10-05" version="1">MITLSAGVGVVPGVSGGSGAAGLTEGRERPYFDDVSPRNVSAVVGQSAVLRCRAKHIGNRTVSWMRKRDLHILTSHIFTYTGDARFSVLHPEPSDDWDLKVDYVQPRDAGVYECQINTEPKINMAVVLNVEAAAATIWGSQDVYVKKGSTISLTCSVNVHSSPPSSASVLWYHGNSVVDFDSPRGGISLETEKTEGGTTSKLLVTKAALADSGNYTCVPNNAHPASVSVHVLNGEHPAAMQTSNRAASYLLTSQLSCALLTYLLSSLTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAD8</accession>
    <name>A0A194RAD8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAD8"/>
    <dbReference type="STRING" id="76193.A0A194RAD8"/>
    <dbReference type="KEGG" id="pmac:106711711"/>
    <dbReference type="InParanoid" id="A0A194RAD8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265030" evidence="2">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="31378" checksum="6E0870A7A8EE0704" modified="2016-10-05" version="1">MLPIIIPLVLCLATSANSLRDRLTIPSYSAASESQIRFAIENNYDDTGPGAKGPESAYNTYSTLEEALVSYIDDPDTKLPENERMKAILRLINTPKDYERYNPSQAIRELPKSVAEYTGYRNIPTIAPIVLKKQPWHNNQVLYHDPRTNMGIYDLRGISVTNINSVKPRERPQNLYKLEDIHIPGQVGQVKSLPVPNYYPYLTKFIPAQSQYESNPQQSYSYGHRNTWPPRDENDHHDSRVEASMRGYYTFTGADGKQRTVHYTDSNRARPVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAZ1</accession>
    <name>A0A194RAZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAZ1"/>
    <dbReference type="InParanoid" id="A0A194RAZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="11121" checksum="9DF5065F12E1F220" modified="2016-10-05" version="1">MVGCTAAGLYGCWGTVAGLYTCSCWLVVVVVFMSVSSVSSVSVRVSVRVSAASVGASGDYAAFHSLLKSCAAKCLGAWCGTACTPGGCAPPAAPWYSPPYVREPPYDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBY1</accession>
    <name>A0A194RBY1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfakinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBY1"/>
    <dbReference type="InParanoid" id="A0A194RBY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265069" description="Sulfakinin" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8160" checksum="F9D99665510F677C" modified="2016-10-05" version="1">MRLVTLIGLALVVALAASFQWCEGAVMRGAGLADDDEYRARRLYREYGMRRAARADDSFDDYGHLRFGRSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCX6</accession>
    <name>A0A194RCX6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Programmed cell death protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
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    <feature type="domain" description="EF-hand" evidence="6">
        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="222" mass="25937" checksum="FE124A2C82DBC602" modified="2016-10-05" version="1">MSFQSPMPSREFLWDIFRRVDKDRSGYISSDELQQALSNGTWNPFNPETVRLMIGMFDKQNRGVISFEDFGALWKYVTDWQNCFRSFDRDNSGNIDKQELKNALTAFGYRLSDEVVTIMVQKFDRFGRGTILFDDFIQCCVTLYTLTSAFRQFDTDQDGVITIHYEQFLKMVFGLKVIYVLRSFLNTNPHLATSKIVFRVTKIFENLRSKNVSSSLYLFTIG</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
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                <person name="Wang W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="7"/>
            <end position="44"/>
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            <begin position="16"/>
            <end position="33"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ16232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="83" mass="9078" checksum="15783C1E389F32ED" modified="2016-10-05" version="1">MRGVCILTDVAEGPQQRKQSAASTAKARSAAAAENQGLSPAHRSPRSIILSYTHWPTHTIHTSIPRPRPSSLAYYMGYGYKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFN0</accession>
    <name>A0A194RFN0_PAPMA</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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            </authorList>
            <dbReference type="PubMed" id="26354079"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="20150" checksum="259C3FF5A2607C8B" modified="2016-10-05" version="1">MGHGSKKVGKHCSRPFISINGNASLDVPNLRGATPAAMLQAGDCLWLGSKVADRVREHALLTTRRSIFRRLTYEKKFRWWCVVAMPFMAFYVTGLVLEIDTLYMFKMFLLVCFYAVLHFLGNALFDDELKNIFPLSVYLATKVRESAECRASGHCAGLVLHNVGCGDHLDHVISQNHSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG55</accession>
    <name>A0A194RG55_PAPMA</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">RR48_13654</name>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
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                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Xiang H."/>
                <person name="Feng X."/>
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                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RG55"/>
    <dbReference type="InParanoid" id="A0A194RG55"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="17733" checksum="33BAA46C002519B6" modified="2016-10-05" version="1">MHLHLRMSMGDGRLAIVANSADLGIATPLAVLPGLEARVSARLEDALWKMAADISMPSFTVNALARLELDDPFIETSGSLNLTSTYLEDYFIKMEFKKDFSDVESVMGGGIQIQQGDYNNYVANEQTATWIRRNSEATVAHRQSQMQMRCQPLINGEGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGQ1</accession>
    <name>A0A194RGQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGQ1"/>
    <dbReference type="KEGG" id="pmac:106710661"/>
    <dbReference type="InParanoid" id="A0A194RGQ1"/>
    <dbReference type="OrthoDB" id="7481147at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="34180" checksum="B477E60884FA0F88" modified="2016-10-05" version="1">MEDISEFESFELNFIDVIGALQSMISSEAHLREAVRTEAARAEAAETACTEAKRVADDNRANAAATAAGATQASHALAAAQDELTTIKSKIELSERQKSLLEEKCSEMSDRIGVLEKELEELRPLQSVHSALQKQYVELESRVRVATEEARNEASSLESEVRRVERCARGGEEVRTRARLAAAAHARERKLAADEKQHLTAELMRANAEIARLGSIVSELQCRLSDYSNNKSKMKLITESESDTLAELRAALEVERAGAAKTEQALAAALADNLTLATQLHKQDNIEHTQASPSKQNNTTTNISPIDLFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKA0</accession>
    <name>A0A194RKA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Circadian clock-controlled protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKA0"/>
    <dbReference type="FunCoup" id="A0A194RKA0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKA0"/>
    <dbReference type="InParanoid" id="A0A194RKA0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="344" mass="38238" checksum="0F4686E942221C77" modified="2016-10-05" version="1">MKQRRLAQSGSAARDLYRHCTGVGVGTFPGHVGSFHTLQCADLRAIQNRRADDHSRASLAQARRACWSPRQVVAGSCISGSRHRAPAGRSLTTSYSRVCATLNMLSTVLLIALPLVTAEIPSYIKVCQRNDPNVDKCIMNSVEELRPKMIKGIPELDVPGIEPLSLGQIALARGPQGAKLTAVVNDVKVRGPSNFIIEELKSDLDNNRFDFKLLLPRLDFNGKYKMDIQVLLLRLQGRGNITGSFKDYACNVTMRGHKEKRGDDEYLTFDPFKVKLRVGESSIYLTNLFDGDPILGPATNRVINENSQVFLQEISPVLERSLGELFTEMANKITSKFTYKELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKS4</accession>
    <name>A0A194RKS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin heavy chain, muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_08162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKS4"/>
    <dbReference type="STRING" id="76193.A0A194RKS4"/>
    <dbReference type="InParanoid" id="A0A194RKS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003012">
        <property type="term" value="P:muscle system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="135"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="43765" checksum="324B042ED6DBA310" modified="2016-10-05" version="1">MPKPQVQEGEDPDPTPYLFVSLEQKRIDQSKPYDGKKACWVPDEKEGFVQGEIKATKGDLVTVNLPGGEEKTLKKDLLSQVNPPKFEKVEDMADLTYLNEAAVLHNLRQRYYAKLIYTKDFKKDLVAQVNPPKYEKCEDMSNLTYLNDASVLYNLKQRYYHKLIYTYSGLFCVAINPYKRYPVYTTRCAKLYRGKRRSEVPPHIFAISDGAYVNMLTNHENQSMLITGESGAGKTENTKKVIAYFATVGASQKKDPSQEKKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPSGKLAGADIETYLLEKARVISQQALERSYHIFYQMMSGSVPGLKAKCLLSNDIMDYNIVSQGKTVIPGVDDGEEMRLTDVSLERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL43</accession>
    <name>A0A194RL43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDC42 small effector protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL43"/>
    <dbReference type="FunCoup" id="A0A194RL43">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL43"/>
    <dbReference type="InParanoid" id="A0A194RL43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ18553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="52" mass="5971" checksum="5ECB98BF521948E5" modified="2016-10-05" version="1">MATTGSEMWLQWFACCYQPAAQAQRTRRRIDRSMIGAPTNFQHTGHIGKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMK9</accession>
    <name>A0A194RMK9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein lin-54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMK9"/>
    <dbReference type="STRING" id="76193.A0A194RMK9"/>
    <dbReference type="InParanoid" id="A0A194RMK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="250"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="402" mass="45285" checksum="E12B973EE304743B" modified="2016-10-05" version="1">MMNNCQAQPLLVASAASSVTKVNTKPQRKLVRIGPLINKKVTTLADKPVQTSAMSRSSQSLLAPISPIPEVAQNTEDTEVQEEMDSKAALHAIVMRNEELEQEMQVNIKTEMQANQSNMESKIEDMESNVHDELHSEMNMDADDSNIAEVEVDYKRDFVNYSDCDEVNDKSDCHELSGQEEHPLIVIPSNFIKETDNRSTSDVQSGHEDSQQMSSMMSMDAESMNAYQSPRTPQTASENEFMSTEIGLRLRKACNCTKSQCLKLYCECFANGEFCNRCNCNNCHNNLENEERRQKAIRGCLDRNPNAFRPKIGKAKVGGPEMIRRHNKGCNCKRSGCLKNYCECYEAKIACTSICKCVGCRNVEETLERTRRRTPAMPSAVQALFRPPPLLPLKILHDNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMW0</accession>
    <name>A0A194RMW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 4V2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_10698</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMW0"/>
    <dbReference type="STRING" id="76193.A0A194RMW0"/>
    <dbReference type="InParanoid" id="A0A194RMW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ18754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="52105" checksum="3D2191FF5C84A3E7" modified="2016-10-05" version="1">MIILVVLLVLACCYWTYWSAGARRLDRATAALPSPPTLPLLGNATLFIGNSEQIVKTLDEIAVLSYKHKGAVKLWLGPKLYVAVSNAEDAKVILENCLDKDVVYRFLRAWLGHGLFVAPLNTWKSHRKVLLPVFNNKVVEDYLGVIGEQADILVERLSEQIDKGYFDIFRYVTACTLDIVFETAMGERMDIQHSPDTPYLRARHTVMTILNMRFFKVWLQPDWLFNLTSYAKEQSASIDLTHKFTDEAVRKRRLLYERNKSREKNDNSDGKLRVVLDMLFGREIEFTDEQLREHIDSITIAGNDTTALVTAYTLVLLGLHHNVQEEVYQEQLSIFGKSRRNATKEDVQDMHCLERVIKESMRLYCVVPIVARNIDRDLYLPHCGVTLPAGTSAVVGAFAVHRSKAEWGPNADEFDPDRFLPERSIGRHPAAFLPFSYGTRNCIGKYQKHFICAIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS51</accession>
    <name>A0A194RS51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centrosomal protein of 290 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RS51">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RS51"/>
    <dbReference type="InParanoid" id="A0A194RS51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1957"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2120"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="173"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="434"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1776"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1923"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1991"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1957"/>
            <end position="1979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2207" mass="254639" checksum="9B070782D2E71EAC" modified="2016-10-05" version="1">MVETDWRQILSFSQKELLQADKEELCENLSWMEVDDIELNFSDLKTLFRLAQDILKYKSEQVKNLGGELNAFHRKKGKKHSPNDNAGTSSDNALETITHQEEVIKANKDILEKLYADIAELEERKMKYKDQSIDIDKDSISSPDVLSEIDAKAKLENEIVQKNKHIRKLLGYVKILEEENTKFKEKITILKDKLREATKIIEDLTEKLLASSNECNRIKETIGSLELAKSNLLDEISTLRQELLSKGINKDNVNEDAKTKIQHLKNSVKNLRLDIERLTTENTNLKEQLHLRSAPKHSEEKQENRMEELRIKELGDKLAEASKEILRSVNVIDVLKSENKHLKSLFEETHNTDLDIKNESDDGKQRKMINELKKKIKKLVVTLESTEKTLVMREKEVMELSSELGLLKSDDGVATLITAVKNKKQQLKLKDESIKSLIKDVNNLTQVVNDLQIENETMRRQLNLSENDKIPTEGILLEYHNLKEHNMTLSKEIQAIENELVTLEMKNLEQSEIISKYAKLLSVKEPSISKINNSVTKRKNDDTQQSVEEDVLVEGGSGDVNKNLNEVINYQSLIEENEGLRKGLQEIFNYLKDNCDSSTGVVAFECPSLEAVLCALEARHAAGWFAPHIATTLQLKAALGGKDALLTALQQSRKEVFNLMTQLSKESQKCVEMETKVHELESKMKTRTERKSDDYNTSFGTFNSYVFDSENKEIDLQNKKELEKVSLNRNSLYEKEVQNALIYFRSKYEMLFDKMAEIAISTSDEKSKWLIEEENYKAQIENLKLSHISHGDEDNSDISAGLVSSPNVSFLERKCNYLEEMYKNIRTSYENMSNEILENKKEKLKSTLNFETQIQNLVIVIINLTEKIRCSMPEDLFWKQNKIFNEIITKYRQVLNSDLMNVESNKIKHFGNDKINAKETTIKISQNSKDIQDQDKNNDSKIEKTAPQTHHEICSELDAKNKLIEKLIKRNTELQDLQASLIDNTLASETKEEITSLKQNLHQLNEENKQLKEKFLEIKTQYDVVMSQLQHDERKRLNYETEINLLRHQILDLQSVGGNKAVIARLSNEILVAHLQASERHQKVESLKQYLDREKEMRENAEEALLALQKIIEMLTLKYMHDILQTLRLEYQGGLPLTSAENYLYGLKELSDKTKFVDEKFHEIEDLRFSLMAKHSVYDQILNLTSGNCSENMENCPHKLQLTVLNSTQARELEHCSNKIQALEKANKNLLERCNALDKTLVTVSHGLRDTFSEENITKEKNNNITKDIVDIESEDSQSDSDIGSSTKESGTFTLPKPRTTQLTYQINFNSNEKKSVATLTNFSERKFRNSEVLNVATQTNIDAQRINKLIQTENDSTSNELKQHINNLEIANKDAKKKLFDCLSKSEQREKTIVSVHEENKALHRKIQNLVETNTKLTSLNEELQKSVELLKTEFEDVKNSHSEQCNNIKKKAKEDTQSLLESVERIENEKNKIMTEYKELLDRERNDNYENVKTLKSKLVALQAEIDRKATTVGGCKDDIIKQDIVKYTSKNEELENKCFKLENNLEDYKREVVNCQSEVQRWKNLAAERLEKMEQMVLQLKERHNYEVESYKAENQHWLMQLNETQREHVELRTQLSEQKALHVKQLAEKDAQIEQLRSNVHNLKTQIMNMQTMLSVQDPSFDLSAIVEVEEASDFSQQGSDRLELKFDSTFDFHDMQDDFTKMSTSTMIWQEPIIERLRREKQLLSKQNGVLRRQIKAIAARERRSRLDAQNLKNQVFRISTSGSKAVCAESAALHNKIATLQAQLTSARRDNNSSVALWDKWKRQEPIIERLRREKQLLAKQNGVLRRQIKAIAARERRSRLDAQNLKNQVFRISTSGSKAVCAESAALHNKIATLQAQLTSARRDNNSSVALWDKWKRAQQAAERWQARYEEKCQEVIKLEAGLNMARSAIARLEKEKRLLLSRLSEPKNEKLSAREKQDGEASEKRLSRSEYDPSEMQTVPVSTRALLERIEAQQRRIAALEVAEKGNEPLVSEYEKALAEITSLKGQVLKLESTLLETQIRSPYTQEVKPELEYWKSYCNMLKEENSQLTLRVSSLESAPATAHQHRVNDLEQTVLTLRGLVSKLQAEQKSSATNIKRVDSRPTSGRSASDKTRSQLESCKTEIANLKRSIQEKDALLERSKDMLRIAAEREDELLNENTFLRRQLEELTDYKRDSVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAR3</accession>
    <name>A0A0N0PAR3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAR3"/>
    <dbReference type="InParanoid" id="A0A0N0PAR3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="6969" checksum="B1E12AF7005FBEB0" modified="2015-12-09" version="1">MNADSLQATFLNDPVLTKLLSSVSSTDETASPFWTLKLDIIRALLQFGTSVLGMASSTFFSASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAS3</accession>
    <name>A0A0N0PAS3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAS3"/>
    <dbReference type="STRING" id="76193.A0A0N0PAS3"/>
    <dbReference type="KEGG" id="pmac:106718590"/>
    <dbReference type="InParanoid" id="A0A0N0PAS3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="26600" checksum="BB1B286A44B2A5BE" modified="2015-12-09" version="1">MAFADKVVFISGASSGIGAATAIEFAKEGANVVINGRNETKLKNIFQQCAEHGKEPLIVKADISKDEEAKRAIEKTIEQFGRLDVLVNNAGFSKSGTILDGNLMSSYDAVIATNLRAAMHLTELATPHLIKTKGNIINVSSICGSSVPVTPILISYCVSKAALDHFTRCAALELSEFGVRVNVVSPGPVLTDFQENSGMVRDTDQKGFTALKRVSESKEIADLILFLASDKAKGITGSNYVCDNGFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBR7</accession>
    <name>A0A0N0PBR7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460833">
        <property type="protein sequence ID" value="KPJ12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBR7"/>
    <dbReference type="STRING" id="76193.A0A0N0PBR7"/>
    <dbReference type="InParanoid" id="A0A0N0PBR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="20268" checksum="CE3327B07AFDDB26" modified="2015-12-09" version="1" fragment="single">IFQVKLWHIPDGGLSMHLTDWLVELQGHKRRVAYIEWHPTAENILLSAGFDYLIMVWDVGKGLAVKVISCHSDVIYCMSFNRDGSLLATTCKDKKLRVIEPRRGIVLSEGQCHMGTKASKCTFVGSGRVLTTGFSRHSDRQYALWDQHDLSAPLVTDTIDSSSGVVFPYYDYDTNMVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBW5</accession>
    <name>A0A0N0PBW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460784">
        <property type="protein sequence ID" value="KPJ12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBW5"/>
    <dbReference type="FunCoup" id="A0A0N0PBW5">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBW5"/>
    <dbReference type="KEGG" id="pmac:106713867"/>
    <dbReference type="InParanoid" id="A0A0N0PBW5"/>
    <dbReference type="OrthoDB" id="6414280at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857210" evidence="2">
        <location>
            <begin position="26"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="42054" checksum="1FF7A36FBAFE58FC" modified="2015-12-09" version="1">MKTKSFLLFSTSVFAISLFLIVFHSQPPQSIQNIVTQTHQHIKDFQAWVPQEKLRDVEASHLVAGEEYGRLLGLDGRAELWRNTTLPALVTYARGDAHALAVAFVRHAARLPYTVLLYNIGLKPYSLSVVSSYCNSSKCAVVDFDLSAFPSHVSDESIYAFRPLIIQHALSRVGGVIFSESSQRWVGSRAQLAALWARAAQGGLVAWPRRAAVTSLTHPRMFTYLRARADDFLFVQMLDVERLLVSPAAADVMRPWIQCALTLDCIMPIGAQSVGCRFDKKPQYRYSGCHAQDASALSIVLGLRWGFDETRYVERAPLWRRQSEAAARAVFADLQRNTTDDERADQHVEQHVEQHTEHRTELQPERLTEPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBW7</accession>
    <name>A0A0N0PBW7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBW7"/>
    <dbReference type="FunCoup" id="A0A0N0PBW7">
        <property type="interactions" value="2094"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBW7"/>
    <dbReference type="InParanoid" id="A0A0N0PBW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000016">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="75"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="449" mass="50962" checksum="632A8FBD5F5CCD3C" modified="2015-12-09" version="1">MSEETDAPVFSTVDINNDNRDEEDLFASAVQEVSLDSEVNGTSESLEKVSITDMSSMPAVVGSPIMEEIATERANNIIITVTEPQKIGEGMSSYVAYHVLTKTNMPIFSRHEFTVLRRFSDFLGLHEKLTEKYLRSGRIIPPAPEKSIVGTTKLKMTSTPSTESANGTNSSASLQSQFVERRRAALERFLNRVAQHPVLCIDPDFREFLESDTELPKATSTSALSGAGMLRLFNKVGETVNKITYRMDESDPWFEERISRVEGLETQLRRLCGACEALAGERRELAARSHDAARAAAALSAADPHPPLSRALSHLADLHEKIEHLRMEQSNTDFYVLTEHIKDYLGLIGAIKDVFHERVKVFQNWQHAQISRVSYTIYNSRSWESKVERGQQEFDTISRVIKKELERWEETRVAELRATILRYLEEHMKHQAQSIRYWDAFLPEARAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBY8</accession>
    <name>A0A0N0PBY8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KQ460735">
        <property type="protein sequence ID" value="KPJ12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBY8"/>
    <dbReference type="STRING" id="76193.A0A0N0PBY8"/>
    <dbReference type="InParanoid" id="A0A0N0PBY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005732751" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="509" mass="57594" checksum="9DA3DA7F826D1824" modified="2015-12-09" version="1">MRTAVLLVMALAINSTIAHKILCLNPAPSRSHATLGRGIVNTLLEAGHQVTWVTAFPDKSINKNLRQIDLPKSREIIKGNEVTSQGHMSMSMLREFARKVSIAALETSELRNVLINEKFDAVVTEWFFSDLEAGYAAVQQIPWILLSGVVMHPYMEYLVDSVRTLPVTPFMINDFPVPMNFWDRLSNTFSFGMFMFGIWQDSEADYDKQFSSIAKARGVSLPPLSISRHNISIVLVNSHTSFAPAQPLPPNVIEIAGYHIEETTPLLPKDLQDLLDSSRNGVVYFSMGSVLKSAALPESTKRELLRVLGSLPYTVLWKFEEQLEGLPKNVHIRSWMPQASILVHPNVKVFITHGGLLSTLEALRYGVPLLAIPVFGDQPGNAIRAMRSGYARKVTFSPDMAPELERELKHMLADDTYYNRAKELSKLFNSRPVTQRKLILHYIELAIETKGAYHLRSKSQLYKWYELWMLDQLAVVVTVLLFIYILLKKIVSVFTKKNVKEVKKSKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCL1</accession>
    <name>A0A0N0PCL1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCL1"/>
    <dbReference type="KEGG" id="pmac:106711879"/>
    <dbReference type="InParanoid" id="A0A0N0PCL1"/>
    <dbReference type="OrthoDB" id="7364850at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="285" mass="32855" checksum="95265DCDF801D722" modified="2015-12-09" version="1">MENHMHEVPILNQHEVPILNPHMNSMVIPQQQPQQQQPQQQQNHQQPPQQNLQQQQQQQIHQQQPSNNQINHQTNPEAPTAVTDDLKPKLEKKKKEAIDGQAREIIFKVIKFFESEKQNRGYAYPVDNVVKRACAATGLSESTIKRIKRDGLRAEATHTKMTGPKKKRVRKTKVQLDYFQLCALRGIVNSYGSRKEVPTLGKILAAAKHELNYRGGKESLRLILLNKLGIKFKKCEKKNKKPPEQNVLPMQQLPNVIHPPMQQVKPVESQYMYNNMMPQVPPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCX2</accession>
    <name>A0A0N0PCX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCX2"/>
    <dbReference type="STRING" id="76193.A0A0N0PCX2"/>
    <dbReference type="InParanoid" id="A0A0N0PCX2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="54322" checksum="B2AFB6D456B60C87" modified="2015-12-09" version="1">MDMADKDKISVMEESIGTINRPLPDDFRSYLPWACNQLELEYAVFVNKIHQSEHHDMGVSDRSKGKTRKTVRSRADGLSDRTEDLKTGTTQQVSFVEEAINIIAVHDSNGDLVQIIFYKNKHIPRIVIKIIGLIIKFHPQLNSVEFDQGANLYTIYEFEKILPLSNITEVCFDGTFIPDANYEILLDHELLRYLSLSRCKIEDEIIHNIALKLVYPNPASKSLAVLNLSSNRITNDGAKSLAFALRSNRCLIYLNLSGNKLTDEGAASILDSLQEFCLTPEEILASKSRYCSFYLKRNKLIAKKVKELKESDSDKSWAKKKGTRSVPSSVRRKTKTDREVSLHSVHEMLAGNVAGSDSNLFDRATTIVQMAFGVFIDPFSTSNTIVKDEALYCLGNNSLLCLNLSYNDLSYIFVRKLLGILLYQKQADRKPRGLINVCIEGNNLPLSCEEYRLIESIIESGVQRNQPINKKRQQSKVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD34</accession>
    <name>A0A0N0PD34_PAPMA</name>
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        <submittedName>
            <fullName evidence="6">Putative inorganic phosphate cotransporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">RR48_01317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460470">
        <property type="protein sequence ID" value="KPJ14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FI19708P1-RELATED"/>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="57"/>
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            <end position="97"/>
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        <location>
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            <begin position="429"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="506" mass="54770" checksum="F1CC0FA31C8D2E1E" modified="2015-12-09" version="1">MDVEFLKYKFRDGYNGVITQTKWQVGVRHVQMTYMVLCAAALGALRASAGVALLALTDASRRNDSYVQAWDVGDRGAALWAFFSGHALALLPAELYLPRLGDKFVVTAVLLINGSLNAAMPTIVNRGGWTALCNAYFLMGMTQPCLAPVNRALLDNWLPPIERQTAACIIDTGSYVGMILALPASSWLSGSRLGWELVAYAQATLALSLAVLWSLLTAASPEQHHACPDAEREYIKEASAECRKKRQCVPWRSMLRCRRVVGLALAHAANNALFIFYLVDVPLYLKSTGLSLLQCGVQAMIPFIALLMLVTTTAPTIGCLLKSNMMAHVFNVTYIKKVINAIGTVSIVAGLAMAPNMPEQWSYLRLCVLTVTLGLLAFQYAGFIENVRDLSENYRGTLIVITSAFSSVVGAVVPLGTGMILRNENKPDAWRVVFCSIASVYGVCSMAGSALGDAGLALWDRMTGGARGHDFAYHNTGLSPEEASQLELLDMYPNKPIAGTPSETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD35</accession>
    <name>A0A0N0PD35_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">RR48_03164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD35"/>
    <dbReference type="InParanoid" id="A0A0N0PD35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11610" checksum="80D4F1D445DF7A94" modified="2015-12-09" version="1">MAATYRSTQREQASRKVKGELETEWLQAAGLGSLAAPARVGLEVTEAQLGEAVRPLPRDQAAAVRRRVRRLNRTVRRKRAASRARKPDIRDVFRDLEVCSFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDD5</accession>
    <name>A0A0N0PDD5_PAPMA</name>
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        <submittedName>
            <fullName evidence="7">MLN64 N-terminal domain-like</fullName>
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        <name evidence="7" type="ORF">RR48_02729</name>
    </gene>
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        <name type="scientific">Papilio machaon</name>
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            <taxon>Glossata</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460280">
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="6">
        <location>
            <begin position="593"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="792" mass="89576" checksum="4B7D8F2EF5BFBA3E" modified="2015-12-09" version="1">MDSPKIIYKYYSNPAFCSQSEVVFAQKSCVTKLVTPSRRMPPLGGNSPRKNEIDNRIVRTDISDNPLRLTPAGRMRDEPPELPPKPPKYQRQFQRQASLICKPTRQIVRCRTRSEDLEMAQLRQTQRNKYERNAESDDGLEDSRMKHRYEVIRDIDDGLDYSPTKKRIVEADASEIEEYNVDGPDENEMKEIPTEIVKTVNGKTHRYAIVPSDDEEPRKMNVTFSSPIMSQKNLIATQKLHELLSTPRKLKSYASQPSVRITPNKQTSPNVYVDTPKKLISSTPTQGVTPSKSCANLSIMRSATSPISPKVPQKLNYGLSDEFERQDVFVTSFRDKSRDRSLDMDRREASRESRRNYDNRGRDSQRRDKNTAIIMPRVAPQSPSVYSEETYKSLSTLKAVNSSFASLTISALMLTLCGGLTTGLSFYMMYTMGRRYYLDFGVLSGFTCFLLGMLGLRSRRNQLLPNRNYISGYIVLSSFSLLSAFGLLILLSVQPLPGTALNDITSGAVCSISILSLCLATIGLLASYCCARDPPDNRVGTTRVTMPDHHYREAAESLLESVSNTRYRTVSQTHSVNLTTEDLLAGYRPYGRMSSVRRFFCLFVTFDLLFTSLMWLICVMMKGESLVLIFNREIVQYSIKTSLFDVVLVAILRFLLLILFYAALYINNWSVIALSTGGTCAFLIAKVFVFDWPNASQPVYQVFLILTSFTLAWGEAWFLDFRVLPLEMGASSHRPTVSERTPLLQPVRPAVPHSTYGESTVNWFSPVETPEASPRPRLPGEQVILTQELVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEC5</accession>
    <name>A0A0N0PEC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEC5"/>
    <dbReference type="STRING" id="76193.A0A0N0PEC5"/>
    <dbReference type="InParanoid" id="A0A0N0PEC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="12407" checksum="06346787766F4F2C" modified="2015-12-09" version="1" fragment="single">FLNKSLLQQHKKIHNNIKYSCQFCSYFGTTVKCLSSHMKKVHTEPTIPCNICGKKFHFQSKLKQHQLVHTGEKPHKCKVCGKGFNSTYSLSTHKLIHESEYIYIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEE1</accession>
    <name>A0A0N0PEE1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protein 237</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459836">
        <property type="protein sequence ID" value="KPJ19771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEE1"/>
    <dbReference type="FunCoup" id="A0A0N0PEE1">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEE1"/>
    <dbReference type="InParanoid" id="A0A0N0PEE1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ19771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60211" checksum="1678318178E9219A" modified="2015-12-09" version="1">MKAGKSVEVKEEIAEVHTSARSPSPKRKGTETRRSRSASRKLSNGHVSNTEPLDTPTTVEEKPETSAEKAKTKDNWINSEQESLDVEIPIHDQIKLGILGFVEKEIKKSDKNPSFVFYSHDPNGLEEKFMKNLSRPSSGHKEKRSPSYRKKKRHSSRHRDRELHDFDVPGSSLSALEKVDDYLKEYNKDEVVTLSGELEIEPNDTENNKGTSREIRHKQRKTRRKTRDERLESDAVSKEVSPKVFKTGTKSKNGTKPVRPTDLTTMLERLESNVPYHDQYIDNPFSSPSPLTSPNDERLDPFTRRTDKIYLQGGGTFRAVSRDRILQEQQSRDDDKYLRLGNLTPLDMAIMVQKAWRSCTPACHGVLGGLSLMHLLLISYSDSLDGGHLSFHAVVTMPYVATYYFFCVLCLLSVLDRLDVASIEVSRGLQPWFQPIVLVILYTACLLVCTAARMYDELMVYQYAPVFLNSTGNVTVATVPSFYHTWTHLSIWRAVLSILGLVYFVISSPPDLLQAGLTQLLHYKHPLQSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEP2</accession>
    <name>A0A0N0PEP2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Osiris 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEP2"/>
    <dbReference type="FunCoup" id="A0A0N0PEP2">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEP2"/>
    <dbReference type="InParanoid" id="A0A0N0PEP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012475266" description="Osiris 9" evidence="3">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25710" checksum="6B5ED8CD0EE7D227" modified="2015-12-09" version="1">MKAFVILCLVAVTVAMPTAKEDGVMERFISALRDCVETDTMLCLKEKAMKFTDNLAVEKDLNLVEGVTFAKTGSPRSARSYEPLDTDPKAREMQIEERIMDNVVDFLESHALQLRMPKSFIEDNSVEEEGRGKKKKKLKKLLPILALIKLKLAALVPLFLGIIAFAVFKAYLLGKIAFIAAAFGALKKLLESKKNSGWSEPPHEEHGWESGGGWGRSQDAQNLAYAAHAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEQ5</accession>
    <name>A0A0N0PEQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin K-dependent protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459718">
        <property type="protein sequence ID" value="KPJ20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEQ5"/>
    <dbReference type="InParanoid" id="A0A0N0PEQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857455" evidence="6">
        <location>
            <begin position="18"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="464"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="684" mass="78774" checksum="303C324ED27F6BCF" modified="2015-12-09" version="1">MLTKLFIFYFTLKVIVAQINGEFWWLNDKLLKLYKVEPPQPKFEDIGEFDTDESAKIVFRDNQFDATQKEETFSDTTTVKTKDIEAIIHFKDHSKLLNPVEVANKTEAFETQNRIDTVGELKKDDNNYKEDVFNFVFPDDVASFKSDKNKNNTNNVNAYRSESFVNNLNKSETSNNRIFNNTEEDSSLSENICTYMKKSECSRCNGFPYIPENQLSHLKSAINIQNVCCILPVTKTKPSKIRFPSSDYYNRIKRSNNDDNISPALKQRKNLMERKYGTQTTASTIAQKIVTPDEEYIDPYLNIKNTNFKQKVNEFKSSKEDNNNDYIYNDYYAAELPKPSLVGLYSDHSPPNWSFVHPNKEYSYNNDDSVEEEIPSFGYSTIDPRQVLQGFKLLNLKNRVQPPVRTLRRPTTAESLTDSGEKMFQSESSVDEDYDDYTDVTEKFYKNCGRTKEDNDHIYNFDSTLGDSPRGAHPWLLLVTLSKRRQSILCYATLIHPRAAVTTADCTYEMKGEITIVAGAWDLKEEKRGHLQYRKPSVRAHQQYTPGKLAYNIALLYWRYPLRLDFHVQPACLSDNTGNDCIFVGWGGYDQGVRQRPRWQRASILSSENCAENMSNEHEFDLSIDTFCASVDSKTTVTGPGGPLMCKTNDVFYVAGLSVWRNHVVVLMRPREWTIRAMTALGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFJ8</accession>
    <name>A0A0N0PFJ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01010698">
        <property type="protein sequence ID" value="KPJ20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFJ8"/>
    <dbReference type="KEGG" id="pmac:106707280"/>
    <dbReference type="InParanoid" id="A0A0N0PFJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="18791" checksum="4F4E18ED9AA8BC13" modified="2015-12-09" version="1">MVALLTSCRRDKILEVLIFLISSTLVNSQCFYKDDSSKKLSPESRMSLYRGQLEFTLHLFNEINKMVPDDNIFFSPFSVYHSLLLGYFAAGGQTEQSLKRSLKIADTLDKINLMTAYKVDKTSRAMNNNSDSYEFTSVNKMFVDRGVNVRQCMLDVLSAEIEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFM2</accession>
    <name>A0A0N0PFM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01043536">
        <property type="protein sequence ID" value="KPJ21404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFM2"/>
    <dbReference type="InParanoid" id="A0A0N0PFM2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="14125" checksum="CBB3AE2833ED6F02" modified="2015-12-09" version="1">MDTLKNVFGANEEQRRTKSKIRSPDGSSVDEDSPMTDYVTLRKNPRTDIQDLRNDFQTFQSRIMAKLESWFTKQEEKFEEIKASIKFMNEYFEDLKCKTEDVARRLNELEIKQSTESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFW5</accession>
    <name>A0A0N0PFW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynactin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01038180">
        <property type="protein sequence ID" value="KPJ21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFW5"/>
    <dbReference type="STRING" id="76193.A0A0N0PFW5"/>
    <dbReference type="InParanoid" id="A0A0N0PFW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="12050" checksum="3A1D6F7BEF6B5672" modified="2015-12-09" version="1">MRALQQQNVRLRETLVRLRDLSAHDKHAMQKMHKDLEQYKSEIAELSRTKEKLSARVEELEAQVADLREQVDAALGAEEMVEQLAEKKMALEDQVKDQISRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5N0</accession>
    <name>A0A0N1I5N0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activator of 90 kDa heat shock protein ATPase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5N0"/>
    <dbReference type="FunCoup" id="A0A0N1I5N0">
        <property type="interactions" value="1915"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I5N0"/>
    <dbReference type="InParanoid" id="A0A0N1I5N0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="372" mass="42561" checksum="E077B102E9A9AFC0" modified="2015-12-09" version="1">MAKWGEGDPRWIVEERPDATNVNNWHWTEKNAGPWSKDRLKELLNNLIIAQNGIDCKVTEVEKVDGEASANNRKGKLIFFYEWDIKLKWEGRLAGASELVKGEVHIPNLSEENDVSEVDWEGRLAGASELVKGEVHIPNLSEENDVSEVDMTVTIKGSGEEAQRVKSFMHNVGRDEIRKQLKEYIRSLKEEFSKGLILPKKGETSVKPDSVSTITSGFNKKINMEPVVSTEKKQIGCKLDTKTIELTETFQCRAEEFYNAMTRIEMVTAFTQGHVKMDPEKGGKFALFGGNVTGEFKELVPGKKIVQYWRYKQWPEQHFSEVTFTIDEKDDHTLVTLKQELVPASEVEQTEENWKRYYFNSIKRAFGFGAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6W8</accession>
    <name>A0A0N1I6W8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein unc-93-like A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460655">
        <property type="protein sequence ID" value="KPJ12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6W8"/>
    <dbReference type="InParanoid" id="A0A0N1I6W8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="52938" checksum="3A4DD4E007A7DAA8" modified="2015-12-09" version="1">MHIYIVINSIKYPPPLAEGRCGRRGGGALGRDHEGRRGPSIRHNPQRGACGACGTSGFERTSDMGSLPELAERARPAALRSAARTTSDPHRHRALAGAGAPQLPVPTIYKKEWPWRKAKAPARGLAPGGGGRRRDSAASSVGAASVRRLIVRPPAPVPRSAVVRFTLLCAASGLCAAALLPFTAFAGAEAGAAPLAVMHAVAAIAAPLAPSLVQRAGPRLVVTAAHALVAALVGAHALALPLWALLSLYALCGAALSPSSLALSVSAAALSQTAGDENRRRVVLRRALRGLRAAQDLGLVLGALLLGGALALWPEEPTTVALADNVTATRWPLLDDYYIEDDYEERTCGAAGCPQVRMVSGGAGLNAAGRRALAACWAAMALAGAALAAAGASTSAAPPDARAAIADPRAIFAAPMGFFIGLQQGFIYTSYMRWYGVCVGGWGGAWRALCGAGALQALAAATLSMAAARAGGAGRALAAGGGAAHGSLLVASRRRECTRPEDGPPMGPKLVGAVTGRSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7L4</accession>
    <name>A0A0N1I7L4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="KQ460968">
        <property type="protein sequence ID" value="KPJ10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7L4"/>
    <dbReference type="FunCoup" id="A0A0N1I7L4">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I7L4"/>
    <dbReference type="InParanoid" id="A0A0N1I7L4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="98"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="30199" checksum="24361A31E7C6A142" modified="2015-12-09" version="1">MPPGKRGGIRGKRSNHHVERNYAERLKDLCVHSSEDSDSESSNGTDSSNNSDDEGIQANFSISMWDLNHCDPKKCSGRKLLRHNLIKNLKLGQRFPGLVLSPVGSQCVSPNDKDIIEKYGLAVIDCSWAKIDETPFGRMKSPHPRLLPFLVAANPINYGKPYQLSCVEALAAALFITGHKQEAKFYLSKFSWGHSFLELNSDVLNLYSACTDSKSVLEAQNKFLESVGKENEDSRPMWPPSDSDSDSDSDSDSDSDSDSDSDSDSECEDDVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I910</accession>
    <name>A0A0N1I910_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460240">
        <property type="protein sequence ID" value="KPJ16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I910"/>
    <dbReference type="InParanoid" id="A0A0N1I910"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="22303" checksum="D01888D63E9E7750" modified="2015-12-09" version="1">MPICPRSSATFPSKHLNLTLSRHSISEYMNSKKTNDSNGKRYNLLEMCTETWRGAGVARSPSHESVTTDLSLFSVSSAASDARVLRMLACKAGQGPDPSIRVASPNPDGKASKRSSATLPLASGESGDACREVLAGCAALCAQLGLRRSFSAADVCQVHNPPPPRRRQQDQLHELSSLSEIPRPHRQTSSGSNSKYSLMSVLMEDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB67</accession>
    <name>A0A0N1IB67_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Osiris 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB67"/>
    <dbReference type="FunCoup" id="A0A0N1IB67">
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IB67"/>
    <dbReference type="KEGG" id="pmac:106708237"/>
    <dbReference type="InParanoid" id="A0A0N1IB67"/>
    <dbReference type="OrthoDB" id="8194491at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF1">
        <property type="entry name" value="FI01546P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873836" description="Osiris 9" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26596" checksum="56CC6AC5D8B7C6F4" modified="2015-12-09" version="1">MGIMWKIALSVAFLATVYTSPIENGVAENLVGAVSDCVDGDTSLCLKEKAYRLTERLAVAKSLDIYEGISLVNTGSARSSRSYEPLVEDPKTRETQLEERIVNNVGDFLDNHVLQLRLSEDSEGRDLDDEARGKKKKKIKQLLPLLLLLKVKLAALVPLFLGIIAFVAVKAVFLGKIAFAINAFNLIRRLLSKNNHDSGVVSYAASPQHHDEHPGYSYEPAGGWSRRVNDAQSLAYSGQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBG4</accession>
    <name>A0A0N1IBG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBG4"/>
    <dbReference type="InParanoid" id="A0A0N1IBG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="13770" checksum="C9123414BAAA197E" modified="2015-12-09" version="1">MFSQTVNGIDFVVSIGTGSPRCCAKGALLHRDRVQFAYSQASALSRGTRLSNIIRSLYITTLSDACAGCAPPASPPPPSLALAPPPTCEAPPPFAFTISTRYIRIGRFVPGTKYVVTRSCIVSPARQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDD9</accession>
    <name>A0A0N1IDD9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDD9"/>
    <dbReference type="InParanoid" id="A0A0N1IDD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873941" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="686" mass="80664" checksum="B2B436C0D6C5FF3C" modified="2015-12-09" version="1">MNTALLLLFSAAALGGASALSIKLRQNPETLCLGQDNFLRIASVDNCYEYYQCYAGRSYLMQCPEETWFNEEDQVCDRSELPANCRTEIEPEPEPEPESEPETDPDQEIEAEEEVESEDEEEEVEEGSEPEEEVEEEPEQEEEIEEGSEPEEEVEEEPEQVEEVQNNSETEIVQDVVQEQDLDSENDLEVSLPEDIVESEESQEEGVERDEEDVDAEKENDNEEENNEEEDEELEKEDGDVEGDEEIDDSDNEVVDVNEENNEEHEEEEQDVEGDEEVDEDDEEVEGDVDEEEESENLEGEAEEDEDSTENDEAFKLNAQQKQHHHHHDHDHDHHHDHDHDHDHDHNHNHEQDQEVNEDESNEEVDEDFDATQDDPLMKFVKAYREYKLQGELDSDEEEIEETLRNKPHPPQPHNNLYPYGQYRVKQQEIEDVENEEELDEEQEEPQKLSMRFRRSLLRQSEEEDDDENEDSLEEESENQAGENLEDINENDDDDAQNNEELSKRLRRSLKRQNEDEDDAQDEVDDVIDQDEEEVSKRLRRSIKQQNEDEEDTQDEEEEEDDDDQDDEEVSKRLKRSLKRQNESEEDEEYENDEEDEEEGENTGTEENDEQENEDEGEAKLKQRQNEEDDNDDDNADENEEDNNEDLKKQDEVNDDDDDGDDDDEEQAIEAEGKRFLRRLFKSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGR7</accession>
    <name>A0A0N1IGR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGR7"/>
    <dbReference type="STRING" id="76193.A0A0N1IGR7"/>
    <dbReference type="InParanoid" id="A0A0N1IGR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14108" checksum="7A059697D6BE832C" modified="2015-12-09" version="1">MALDGKICLWLRPPGFTEERAKYESCEEIKYVKWVQALTNDVIESDSGNSDNNSESGKDTDADSESDDEEQTAIANKFAALAHEIMAKGSQHSVCKDGLNNPCAGFQLVLLSLILCERAPNFLLPEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IID9</accession>
    <name>A0A0N1IID9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01063739">
        <property type="protein sequence ID" value="KPJ21637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IID9"/>
    <dbReference type="STRING" id="76193.A0A0N1IID9"/>
    <dbReference type="InParanoid" id="A0A0N1IID9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="181" mass="21097" checksum="29FCC84528007BEE" modified="2015-12-09" version="1">MLRLFNKVGETVNKITYRMDESDPWFEERISRVEGLETQLRRLCGACEALAGERRELAARSHAPHAQPPHSPPLTRIRLSPEHCHISQIYTRRMEQSNTDFYVLTEHIKDYLGLIGAIKDVFHERVKVFQNWQHAQMQLTKRRENKAKAELANRPEKIEQASNEIIEVMQVDQSSSSCLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP71</accession>
    <name>A0A0N1IP71_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP71"/>
    <dbReference type="FunCoup" id="A0A0N1IP71">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP71"/>
    <dbReference type="KEGG" id="pmac:106713308"/>
    <dbReference type="InParanoid" id="A0A0N1IP71"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="520"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="803"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="923" mass="107541" checksum="EC5E909D28DF1EC1" modified="2015-12-09" version="1">MSVENPASDNDCEAGKVNGNKNEHVNGVHNGYSSSDRHKSSHKSSSKDKHRDKDRDHKSSSKHSSSSSRDKDKHSSSKNHSSSHKSSSKDKDRGDQRERSEKSKDRSDKDRSSKDKHRSDKEKHREKSDHDKHKHSSSDGEKKSSSKDKERDREHKSSSSSKDKDKSKERDKDHHRNDKHRSDKHSSSRDKHRSKDKERSSDHQDKIKSELDYKESVKDEPMQIDDHEIKREIKEESEDGYNAGNTTVSSCDYSMSQFKDEPLSELPPEGESEEDTPLLERMGAKKRLASESEEDTPLLQRKKSKKKVKKEPTYDDDEDEDDIPKKKKKKPEKSKSTKVKTEPNDGPSPTKRKKKQEEEQEVWKWWEEEKKDDGTKWNFLEHKGPVFAPDYEPLPENVKFRYDGKIVKLSQDAEEVAGFYARMLDHDYTTKSTFNNNFFADWRKMMTHEEAKLIKDLNKCDFKEMHAYFLSVSEKNRNRTKEEKAAIKAKNEEIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMLKRRVMPEDVLINCSKDSKIPKPPPGHKWKEVRHDNTVTWLASWTENVQGQTKYVMLNPSSKLKGEKDWQKYETARKLHKCIDKIRETYKNDWKAKEMRVRQRAVALYFIDRLALRAGNEKDDDQADTVGCCSLRVEHIQLHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLELFMENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQRQLDELTDPNASIPEKILAYNRANRAVAVLCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLREATKAAKRGSVKEKIAADKKKTALERLKEQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWAIDMATSEYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP91</accession>
    <name>A0A0N1IP91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP91"/>
    <dbReference type="FunCoup" id="A0A0N1IP91">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP91"/>
    <dbReference type="InParanoid" id="A0A0N1IP91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="10"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="360" mass="40722" checksum="7A2B99D703E7F3F4" modified="2015-12-09" version="1">MNNSFLKTPQYTNYDDLVKLFDELETNYPELAKVYSIGKSVEGRRLLVIQISEGVKSTHPERPAFKYVANMHGDESVGRQLMIYLAQYLLVNYGKDDRVTKLVNTTDIHLMPSLNPDGFEKSKFEGDGRNNAKGVDLNRDFPDQFDRNRSNDDAYLFGGRQPETAAIIRWVLSKQFVLSGNLHGGAIVASYPYDDSRLYVECLQLEACLLCGRGIAPGEAHSCNRSCLNFLGGMQDFNYVNSNCFEVTFELSCCKYPRAAQLPHFWDINRDPLLAYIEQVHVGVTGFVLDEDGEPVKNAQIIVEGIKHSVRSTEHGAYWRLLLPGDYNITTVASGHRLNSTNKARRIDFAILITYQLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFS5</accession>
    <name>A0A0N1PFS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclin-dependent kinase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_01271</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461069">
        <property type="protein sequence ID" value="KPJ09874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFS5"/>
    <dbReference type="FunCoup" id="A0A0N1PFS5">
        <property type="interactions" value="1865"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFS5"/>
    <dbReference type="KEGG" id="pmac:106716399"/>
    <dbReference type="InParanoid" id="A0A0N1PFS5"/>
    <dbReference type="OMA" id="FPHCDES"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07865">
        <property type="entry name" value="STKc_CDK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000227">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ09874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="401" mass="45795" checksum="7AFA3461D27AFD7F" modified="2015-12-09" version="1">MQNVNAQREPAPVLSTSSTILNMREKEKYIEDFDFPFCDESSKYEKVAKIGQGTFGEVFKARARNSSKKFVAMKKVLMDNEKEGFPITALREIKILQLLKHDNVVNLIEICRTKATLHNKYRSTFYLVFDFCEHDLAGLLSNVNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKNGVLKLADFGLARAFSVAKAGQVNKYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGPTEQQQLILISQLCGSCTPDVWPGVENLDLYNKMELPKGQKRKVKERLKPYVKDPYGCDLLDKLLQLDPAKRYDADTALNHDFFWTDPMPCDLANMLAQHTQSMFEYLAPPRRPAHLRHHHHVAGAQAKPSQPVADSGYQDRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGI1</accession>
    <name>A0A0N1PGI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGI1"/>
    <dbReference type="InParanoid" id="A0A0N1PGI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="33272" checksum="8CBBD17275A6D887" modified="2015-12-09" version="1">MNVAGRRGKGEGAVRARGARIDARHATRRTARRTQEAGRRRGTHAARLPALWNLLQNFSEGNLPSAGANDYLRELSPNAAPQSLKARYHIGTPLELISTSTLLKRFKSSVIALIFKKPGMTVTVMSGGRRGAGGRRGIMQSGHRLPCTRTTVDVDCEVQNVRSGSAPCVKPGVPPRPHLAPGLPTLALLMLHALRLPPPAAADVWLLCRPARRQAFQTDKGGSSLSRSPLLTIEAVRVGGPGFVSGPCSPPETPAPLTPTAPPAPKAPPAPLGPTSAVMHGNQPLRRRKLTLNKELIFRLTTTYEKMRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGP9</accession>
    <name>A0A0N1PGP9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4776 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGP9"/>
    <dbReference type="STRING" id="76193.A0A0N1PGP9"/>
    <dbReference type="InParanoid" id="A0A0N1PGP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031949">
        <property type="entry name" value="DUF4776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39079">
        <property type="entry name" value="FI08034P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39079:SF1">
        <property type="entry name" value="GH11706P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16003">
        <property type="entry name" value="DUF4776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4776" evidence="2">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="35820" checksum="391F2706C6E2C965" modified="2015-12-09" version="1">MGDDEENDKKKKKKNASKYNYSFGDEYPGNLIGHKACNQFQPGLPVPAEMGWLWNAADIPGLKPRRGWTPGGIGKSVAKMMTFKCPRGGQDKDKSKKKKKKGQRPGADMGGGDSEPEEPLEPKPALKVQRKGDVFTIQVNPLKDLTEINPNEDPYVDCDPMVFKIIKKRSPEEQAKVEARKMVKLKKQRDAEIRKALAEATEDICKCAYMDVYCNDLSAIDKVIESCPAFKEPDCICKEESLSSLSSNATWDIEYTPPFGCFDLAPRRRQNLIHVETQYLPEDAGIVEVAKVNKKSFTSIKPKKVCGQKKLRKICTPCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGW7</accession>
    <name>A0A0N1PGW7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KQ460479">
        <property type="protein sequence ID" value="KPJ14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGW7"/>
    <dbReference type="STRING" id="76193.A0A0N1PGW7"/>
    <dbReference type="InParanoid" id="A0A0N1PGW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="172"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="368" mass="40194" checksum="A301A7811159FE9C" modified="2015-12-09" version="1">MEKDCERYCPVPRVPPRKVTIVGAGSDVGRVAALFLKQQPVVRKLSLYDDEPDSCVMGVANDLAHIDTSADVEAFQGRPRLGDALTNSDVVLICGGHFVTPPCCCALDRELFFKNMERVRVASIACSRFCPYAVVAVQTPPVDCNFALCMHTLKTAGVYDKRRVLGVNSISSMRANQLFCALTGADPAATHTPVICGTGRCTRVPVFSKGKAGNFPQTQVECLTKLVREADEIICKVKANYEQGHLSIGFSSARFVTSVMQGLFEKKTFIDSALVEQDQAGKCYGMEICATPLSIGKGGIVEYVVPTLNEVETKLLEESKCDLEDMLNLGRCYAVGDEYCLNPCKIYTFPPCVPCEICRPGEKSKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH58</accession>
    <name>A0A0N1PH58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantothenate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH58"/>
    <dbReference type="FunCoup" id="A0A0N1PH58">
        <property type="interactions" value="2102"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH58"/>
    <dbReference type="KEGG" id="pmac:106711815"/>
    <dbReference type="InParanoid" id="A0A0N1PH58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="255" mass="28266" checksum="4AD8DC09BF01304F" modified="2015-12-09" version="1">MASGSWEEFFAVHLPPTDFEDNRSLLKEFCERHDKHGNRIALVTSGGTTVPLEHNTVRFVDNFSAGTRGSASAEYFLEHGYAVIFMHRQKSLEPYTRHFSGQKLLDMLELNERGPNTTITVKPDSVDVLAPVLARYKAAHAAGALLHVAFTTVSEYFWLLRAACECLARLGPRSLLFLAAAVSDFYIPKDRVMVVANLLQTRHHRVVLVKPDASQEILLTREDVHAGVDIEASIVSEIVRLHTAHLGGPSAPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHR1</accession>
    <name>A0A0N1PHR1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">RR48_03063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHR1"/>
    <dbReference type="STRING" id="76193.A0A0N1PHR1"/>
    <dbReference type="InParanoid" id="A0A0N1PHR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF43">
        <property type="entry name" value="INNEXIN INX4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="36923" checksum="407A83C509F65FD7" modified="2015-12-09" version="1">MHCMSGSDKDDNKDAINNYCWIYGTYTLKSQLNGIEGKHMVYAGVGPGLNKNDDQIEHTYYQWVCFVLLGQAFMFYIPHYLWKSWEGGRVRDLSANLTFPIVAKDWSDGPRQQLLAYFNSLNTCTHNMYALRFAFCEFLNLANVIGQIFLLDIFLDGSFRDYGAAVASFTHHPRLSTDMTDFVSVNPMDKFFPKVTKCWFRSYGPSGTIQFKDRLCVLPLNVINEKIFIILWFWLVILASLSALAVLFRVLIFCIPALRTYILTARLRRIKRSPVSKIVKHYSFGDWFVLYLLSKNINQIVCIDLVKELAKDLQWTECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHT7</accession>
    <name>A0A0N1PHT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELAV-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459670">
        <property type="protein sequence ID" value="KPJ20486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHT7"/>
    <dbReference type="FunCoup" id="A0A0N1PHT7">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHT7"/>
    <dbReference type="KEGG" id="pmac:106716194"/>
    <dbReference type="InParanoid" id="A0A0N1PHT7"/>
    <dbReference type="OMA" id="GSEWCIF"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000480">
        <property type="entry name" value="Fne, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="270"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="38257" checksum="C68319BEE725B670" modified="2015-12-09" version="1">MSKGDSEQQNGSGEESKTNLIINYLPQSMTQEEIRSLFSSIGEVESCKLIRNKGAAFPDALNHALHGGGQSLGYAFVNYHRPEDAEKAINTLNGLRLQNKTIKVSYARPSSEAIKGANLYVSGLPKTMTQSELERLFSPYGRIITSRILCENSGGRPFTGGEQGLSKGVGFIRFDQRVEAERAIQELNGTVPKGASEPITVKFANNPSNNGKALAPLAAYLPAALRFPAPLGRFSSGKSLLAINKGLQRYSPLAGELLGGVLPGAVGSEWCIFVYNLAPETEENVLWQLFGPFGAVQSVKVIRDLQTNKCKGYGFITMTNYDEAVVAIQSLNGYTLGNRVLQVSFKTNKIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHW5</accession>
    <name>A0A0N1PHW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460598">
        <property type="protein sequence ID" value="KPJ13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHW5"/>
    <dbReference type="STRING" id="76193.A0A0N1PHW5"/>
    <dbReference type="InParanoid" id="A0A0N1PHW5"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120454" checksum="5700CEC7436E2E8B" modified="2015-12-09" version="1">MEKFDATFFKVTYKQVLSLDNKCRQLMSYAYTAVYDSGVNPLQMKDNKLGVFIASSTVGDKHLLSDDYTGFKSTNNFFISGCSKAMYSNRISYWFNSKGPSYYIDGGCVGSMAVVDFACQSILSGDCEAALVGGCSICFSSTVTINLNNAGLLCNDGKTKCFDKRADGYVRSESIGFLFLQKAKDAKRIYAEIYHTKLGYCSSPLSDWKIVRHANSKDITEFLKKFYSEIDVSPQEIEYVEANGIANAEDDKNELEAVGEMFGNKERPVKIGCVKSNMGNSESASGLCALTKVCLAYRKGEISGNLHYENPHYDVDAVRDRRIEVVHKNTPFKRGFAALNSFSYTGLMAHVLLKGYYKEKNHKKYISNIPYLVNVSSRNEAGVVRMLDILAATPIDAEYIGLLHNIHKIETPGHNGRGYIILRSNLEEKTCVLSKSVQHYTGIKPPVCFMYSGMGSQWCEMGADLMNIPIFSAAIQKCHKVLEPKGLNIIDILTLKDQTIYDDIMNWHSTGEVGCAYADGCLTLEETILSAYCRGLASKQTEVIRGAMAALKRICPADIEIACHNSAGSSTISGPVDTLKDFVALLTSRGIFAKEVPCGNIAYHSKYVAAVGPPLFEALKEVLKNPKKRTSKWLSTSFLKTRWDEDIAKFSSAEYFTNNLMSPVYFEETSKLIPNEAVVIEIAPHGLLQAIVKRSLESCVHVPLTRRGHEKPTKFLLYAIGRLYESGLNPQVHELYPKIEYPIATETPLLSNLVGWEQNEIWPIVSETKKIRKQGQICNYFISLYDNDNKFINQYTRNGVNVIPEALILVLTWKTLAMARNVDHNQMSIKFNNVYFNHEVSFEENKLAKITISINKGDYKFEVTNYDTVVATGHIMDESQTNKCNFEPNNENSEDDIFLTSDEIYRLLGFRGYSFNKEFQVIRSTNSSISKATVEWTGEWISYIDALIQLNIMKRNHNGISTPKLIRELIIDVNEHVSANDQSKKIEYEAKIFDLYNTVRCGGVTIKDMVFSDRAVVHTQVPSVLFVRKNSPQVLGDDIISVYYAGVSQRDCQQSIFGTKLDLGMDFSGKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI71</accession>
    <name>A0A0N1PI71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459892">
        <property type="protein sequence ID" value="KPJ19541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI71"/>
    <dbReference type="InParanoid" id="A0A0N1PI71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="19425" checksum="CDB7FC1FB6B497BF" modified="2015-12-09" version="1">MKPLVGGSTYYPLANISLEVNINPLLLQMKTGSVLGFAVGRSTRALHRKGSANYTVSHKPVSTMKGTVKMHRTVEELEPLLPTEFGRLVRAKCAFHAHATSITSRARSDPSFVGFSNEHKGVRRVRGAANVDGRFEINTCTQRTWRTTLRGVRKRHVRGGMAETDEHGRFVVNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIM9</accession>
    <name>A0A0N1PIM9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIM9"/>
    <dbReference type="KEGG" id="pmac:106714647"/>
    <dbReference type="InParanoid" id="A0A0N1PIM9"/>
    <dbReference type="OrthoDB" id="6753909at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029375">
        <property type="entry name" value="CFAP141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15104">
        <property type="entry name" value="CFAP141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12309" checksum="BCD7348EBBDBF57C" modified="2015-12-09" version="1">MSKEKENPVEEEAEAEALEEAGILEADVGAHFDQQLASIDPRLSIQMDPLAHHHLRPEMMFIREELRQAKMQTLAVRRAALKKLLVKDFLQEECELRNIGLSYASPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIV8</accession>
    <name>A0A0N1PIV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI/SNF complex subunit SMARCC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01051526">
        <property type="protein sequence ID" value="KPJ21499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIV8"/>
    <dbReference type="STRING" id="76193.A0A0N1PIV8"/>
    <dbReference type="InParanoid" id="A0A0N1PIV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="11771" checksum="F3475CD1F7AA3E93" modified="2015-12-09" version="1">MASLGPKKDGGPNVEFFQAPESLAQFDQIRVWLQKNCKKHVQTDPPTKEGLAQLVIQLIQYQENKLGKNASDPPFLRLPVSSIILSIDITLGSMVLGKMKNFSAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJI6</accession>
    <name>A0A0N1PJI6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459620">
        <property type="protein sequence ID" value="KPJ20543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJI6"/>
    <dbReference type="InParanoid" id="A0A0N1PJI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10781" checksum="CE4639D3C5B184F6" modified="2015-12-09" version="1">MCPQSPPGGVALSAERWASGARSRLSLGAVRRRHAGEWTCRAGAAADTITLALAPRDSADELEVMQHDQAERRLSSAAPPAARLAAPLAAALLATLLTRRDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJU4</accession>
    <name>A0A0N1PJU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GON-4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459858">
        <property type="protein sequence ID" value="KPJ19694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJU4"/>
    <dbReference type="STRING" id="76193.A0A0N1PJU4"/>
    <dbReference type="InParanoid" id="A0A0N1PJU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28096" checksum="F51202CBD3FF519C" modified="2015-12-09" version="1">MESSSDVDSLPRTPATPKSQSLVSPKVVKDGPFKVPQNKVTPTRRKLNLEEEATIALRTRSKLSLSATPIEHIESSFIPPDDVPTVDVDDPVWNEFLEECLNPASALVKNEDDDDADPEYNVAADPDIHDDEEEVLDNSIIKISKKELNDLMTELFNIMPEPSTEELASLFVSRNRSASCSLHIGDFHDTLKDVVANSCVFLYPHLLPPMMYRPDSLKRFKFLPPEDRSEINVLDCIIISAIYKTNERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJZ1</accession>
    <name>A0A0N1PJZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052188">
        <property type="protein sequence ID" value="KPJ21525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJZ1"/>
    <dbReference type="STRING" id="76193.A0A0N1PJZ1"/>
    <dbReference type="InParanoid" id="A0A0N1PJZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="12993" checksum="0278D368C607CF1E" modified="2015-12-09" version="1">MQQGHEKVVAVLLEADTRGRVRLPALHIAAKKDDVKAANLLLENEHNPDVTSKSGFTPLHIAAHYGNESVARLLLAKGADVNCAAKHNICPLHVAAKWGKGATLQTLCPLHVAAKWGKGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK34</accession>
    <name>A0A0N1PK34_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Regulatory protein SIR2 homolog 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">SIR2-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_04730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-decanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-decanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:17932"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:143222"/>
            <dbReference type="ChEBI" id="CHEBI:189688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70632"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-propanoyl-L-lysyl-[protein] + NAD(+) + H2O = 3''-O-propanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:23500"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13758"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138019"/>
            <dbReference type="ChEBI" id="CHEBI:145015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23501"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47669"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK34"/>
    <dbReference type="FunCoup" id="A0A0N1PK34">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PK34"/>
    <dbReference type="InParanoid" id="A0A0N1PK34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097372">
        <property type="term" value="F:histone H3K18 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.200:FF:000002">
        <property type="entry name" value="NAD-dependent deacetylase sirtuin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="17">
        <location>
            <begin position="55"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ18284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="662" mass="72154" checksum="183E6DED22CA1B2D" modified="2015-12-09" version="1">MGGGVRSSARLSGSAARAEQHTAARSATADAAARAAAAARRARAAERAREVEDSPRVLREKCRRLARAVKEAKHLVVYTGAGISTAADIPDYRGPHGVWTRLQRGETVGRVEVARAQPTFTHMALTALWASGVLKFVVSQNCDGLHLRAGLPRRALAELHGDMFAEQCAACRRVYLRTFDTTERTARHAHGTRRLCHTCGRELRDTIVHFGERGRAAWPLNWAGALRHAAAADVVLCLGSSLKVLRRYPRLWRMQRAPHARPALYIVNLQWTPKDAVAALKINARCDAVMAAVARRLRLRVPRYSPRRDPLLAHGVPLAPLEAHTARRAPLSPPALDADSDSDACYSLESASCSSPSPSLESSTSEAEAEGEESDDSVPLCQLAERLRATRRQDPSADRETPQSPARKKFLADSFRSFQVSTVVRPDWNFGTVADFTTTVKEEDDAKSFANGGWPCGSKLRQLLEIKPFDEDEKKAFHLHGRHAAGAGGAAGAGGADRKCKVQLPAADRSDCSDIKSEPGTCSSLLPLAATSGTGSACAERQRQREREEMGAAEAEAAAFIRRAVLVCRASLYPGLHTILGGARGGRGARACAWCTRRYGSRRCLWYGAPPDASALRTARRVRGRRYLCACCPERAHSPHAPLPDDAGWYGKGYRKGRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLU5</accession>
    <name>A0A194QLU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear hormone receptor FTZ-F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLU5"/>
    <dbReference type="InParanoid" id="A0A194QLU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="10511" checksum="E1748A4234B4EF9F" modified="2016-10-05" version="1">MHEDSPKMSVAQGLVASSSQAKNEIAMEVPEYEITCVETKSTENIEMELKISYVNPTSDRGHEALGKRFKLCLKKEKWLYNNYIYIVVRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM58</accession>
    <name>A0A194QM58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-arrestin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM58"/>
    <dbReference type="FunCoup" id="A0A194QM58">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QM58"/>
    <dbReference type="InParanoid" id="A0A194QM58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF18">
        <property type="entry name" value="FI20035P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="246"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="492" mass="55577" checksum="98B08EB5ACCD0F86" modified="2016-10-05" version="1">MRWTDQVRTALDSSIHNAIHSAENRTEWRTTLREMVKRRGRDPQEVFKKSSPNNKLTLYLASRDLVVENGYIDKIQGVLHVEPECLENKKLFGQVTLTFRYGREDEEVMGLKFCNEAIMSLVQIWPAHCNHDREPNSPLQDALIKRLGTNAFPFHLELTPLAPPSVQLVPAKQYHGAPIGTSYDEFIQHEKNYVNAAKCIIYFSVYRLKNKTKIESDENCRGRKKENESLEQAPPRATVEKPFLLSDGRVELEGWLDKATYSHGESINVNIIVSNHSSKTVRRIKIKGPDTPVAPGETFTDSYNLTPHRGATKNWIALEDSYSKSGASLASTVLCNSNSPDDRNVFAIYVSYYVKVKLTLSAMGGDLSLKLPFTLTHSCINEAPTDSVIEEATHKMILEGKENSDEEESKAETENDKQNNNGHDDVKQETAFGDDGEIKSPEDHKCIADVLVNIENKITDRPKKFEGQNVVRNVKPNEEELDLIVKYPCSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMD4</accession>
    <name>A0A194QMD4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate synthase</fullName>
            <ecNumber evidence="4">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_11739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="4"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMD4"/>
    <dbReference type="FunCoup" id="A0A194QMD4">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMD4"/>
    <dbReference type="KEGG" id="pmac:106719605"/>
    <dbReference type="InParanoid" id="A0A194QMD4"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.470">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="15">
        <location>
            <begin position="178"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="413" mass="46195" checksum="B014FED13FCDE03B" modified="2016-10-05" version="1">MAKDLVILAYSGGLDTSCILKWLIQKNYDVVCYMADVGQDEDFEKARKKAKNIGAKDVIIEDLRKEFVDNYMLPAVQMGLIYESRYYLGTALARPCISVGIVTAAKKLGAKYISHGATGKGNDQVRFELSVYSLWPEGKIIAPWRLPEFFERFQGRSDLIEFAKIENIPVAATPKEPWSTDENIMHISYESGVLEDPGVVAPSGIYKMTRDLNKTEDYPSTIDIVFDKGLPVSIVIPSGHEKPMELSDSLTIVQTLNKLGGQHGVGRIDIVENRFLGLKSRGLYETPAGTILHAAHLDLEAFALDREVLRMKKYLQEKMSDFVYNGFWFSPEATYTRKCLELSQQGVSGKVTVQIYKGNVTILSRKSSTSLYNKDLVSMDVAGGFSPEDSTGFININAIRLKEYARFTAQTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNX9</accession>
    <name>A0A194QNX9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CCCH domain-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNX9"/>
    <dbReference type="FunCoup" id="A0A194QNX9">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNX9"/>
    <dbReference type="InParanoid" id="A0A194QNX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052647">
        <property type="entry name" value="Zinc_finger_CCCH-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46582:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="499" mass="55818" checksum="891C85FED0343A8F" modified="2016-10-05" version="1">MSLHGVEEAKAGRRSRGSSLEEGEVSDEAERRPEENEPRPVCRFFSRGACTWGVSCRFLHPGVTDKGNYNMFDVVRGVPTGAPYAAPPRDVAPPESAWERGLRTAKEMLRIANKRKEQDMDFEEKKLHLSVGGVVHDPDAELAYAAAAVGASPPHQHDVPVHRDPEMYSRAYGPVYRGRYPPRPAADERERYYARERIYDTERMYERPPHYDERAATTEELPFHKRRVRSSREVIVQRAEVERREGREGREGREGRVREMREGREGREGREGREGRGDDWADPWMRAEPAARRRRPPSSEDSYSTSRLSPSVIVRERRLASARATAMNPPAPRRRAPSPAAARQLAVNPPPPASHRHKEETDPYGRSKASSRGRNRKKYSRSSSSGSESSSSSSESESESRSSSTSGSSGARRARHARLLNAAARPRMNAKSSAGLAAAVSTAVNKKEVPSEKDMSRKRSAVSPSNDGVPAKKSVSRREELLKQLKAVEDAIARKRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQQ3</accession>
    <name>A0A194QQQ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQQ3"/>
    <dbReference type="FunCoup" id="A0A194QQQ3">
        <property type="interactions" value="1534"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQQ3"/>
    <dbReference type="InParanoid" id="A0A194QQQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="27726" checksum="70A7269C9F927015" modified="2016-10-05" version="1">MAMKHPRVVVFAGAISALVFMTVLSAAFGWVATVIPRVYTHYISAALFAIFGLKMLRDGWKMDPNEGQEELEEVQSELKRREDQESTKERSSSPEGSVSVKSTQSEIPGPSRSPVAESPEAPRAPETPEEPQAGPSTRSEPLRDEKEETLDMLEQGQAENRRRKRNAVIKVLLQAASLTFLAEWGDRSQLATVVLATRENAVGVVVGGSLGHALCTGLAVIGGRMVAQKISVRTVTIIGGIVFLFFAVSALIIGPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR12</accession>
    <name>A0A194QR12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR12"/>
    <dbReference type="InParanoid" id="A0A194QR12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="77" mass="8425" checksum="849D946EF70010C2" modified="2016-10-05" version="1">MMMSICFVELFRKQRARCGVVLQFKVAVERVFPWWAGREAYERAAAGGARGKLLLHMAAPEPPAPPAPTAPPAPPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR39</accession>
    <name>A0A194QR39_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR39"/>
    <dbReference type="FunCoup" id="A0A194QR39">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR39"/>
    <dbReference type="InParanoid" id="A0A194QR39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000028">
        <property type="entry name" value="GTP-binding protein 1,-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="92"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="587" mass="64616" checksum="98E42AD795EB45AD" modified="2016-10-05" version="1">MILVSPTADEYDLLRKQLLERMEAGNGEIIYDIGQGEDGKGLTEDEYSASVATLQSLVSGERVSCVELRRWDCGTGLVGQYLLRTELDHTDFMEIRVAVVGNVDAGKSTLLGVLTHGELDNGRGHARQRLFRHKHELESGRTSSVGNDILGFDSMGNVVNKPDHGTLDWVKICEKSSKVITFIDLAGHERYLKTTVFGMTGHAPDFGMLMIGANAGIVGMTKEHLGLALALSVPVFVVVTKIDMCPPNVLQDNLKMLIRILKSSGCRKVPVMVKTKDDVIVSATNFVSQRLCPIFQVSNVTGENLQLLTMFLNLLKTRMPAHDDKPAEFQIDDTYSVPGVGTVVSGTTLAGTIRLNDTLMLGPDALGRFAPVAVRGIHRKRMPVPEVRGGQTASFALKKIKRSQIRKGMVMVSPALNPQACWQFEGEILVLHHPTTISSRYQAMVHCGSIRQTASILSMSRDCLRTGDKALVRFRFIKHPEYLKHGQRMVFREGRTKAVGNVLRPEPVSAMRAPPTRHKHDIHAHTHSAQRRHNDHDQQDKDTDVTAADSPFEVQADKRGAGAGGGRRPRKRHDKPGQPSHSAVPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS27</accession>
    <name>A0A194QS27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS27"/>
    <dbReference type="STRING" id="76193.A0A194QS27"/>
    <dbReference type="InParanoid" id="A0A194QS27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="56" mass="6249" checksum="DE4F77B3E5FCCD4B" modified="2016-10-05" version="1">MTQKKEGGEAKREMLKIALRSTGGWATLTSTNAWAARSQPARVEPKIDYFDNPPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSB3</accession>
    <name>A0A194QSB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein C6orf203-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSB3"/>
    <dbReference type="STRING" id="76193.A0A194QSB3"/>
    <dbReference type="InParanoid" id="A0A194QSB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057896">
        <property type="entry name" value="MTRES1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25818">
        <property type="entry name" value="MTRES1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mitochondrial transcription rescue factor 1 C-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="152" mass="17223" checksum="13E9C95BBD7B4FB9" modified="2016-10-05" version="1">MGTDDDMSHTEMLVSETHDDEEEVFDEDDVSLSRDSKLVKFKTTSLRTDVVIKSALGVSRNKVEQVFYESKIRVNGKKIMKKSHAVKVGSEIDVVKSVSPHNPDHLYVARIEVLNIVPKEEDIAITVRRFKNLLIENYEDDPYKPSSANSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSD5</accession>
    <name>A0A194QSD5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein abnormal spindle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSD5"/>
    <dbReference type="STRING" id="76193.A0A194QSD5"/>
    <dbReference type="InParanoid" id="A0A194QSD5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="757" mass="92367" checksum="53A8DB78E941685A" modified="2016-10-05" version="1">MQRDKKEFEQLKHAAIILQRRYRALMLMRICKKDFEKLQNATIALQKRYRAKRQMRKERSEYLEIKNSCIIIQTHIRAYLAMKKQRTAYILQRKSALTIQKYFRSYQITKTIKMKYLHLRNSVIKIQIWYRSIMQMREQRKQFEQLRNAAITLQKRYRALLLMRICKNEYNQLQKATTVIQTYYRAKIQMRMERSQYTKVKTSCIIIQKHIRSYLAMKKERTNYVLQRNSAIKIQRYFRLYQIAKKDRTKYLELRRSVIKIQTWYRSILQMYRQRENYEQLRNATIIVQRRYRALMLMRVCKNEYRKLQKATIVIQTRYRANCQMREEKSKYIKLKTSCVTIQTALRAYIKGKEERQAYLQLKESAVKIQNWYRSCKKSREIVQQCYTEYLEYRKKIKIVQSVIRMYVQRKRYLEIKRATITIQTRYRLYKLTKLQRQKYLQIRQNIITIQAHVRCYIQRKRFLRFRSAILFLQVRYRYKKQKEVLKQRKVAAAICLQKNIRCYLATKRYNNVIKYIKLIQELWKGKQITRSIRSEFLKKRQAAIKLQAIIRGFLARKRFVVQKEMLIKQKEEQKRNWAASKIQALFRGHRIRMTNKDTQVEQLRNRWRCGALESKQESLKERNEEAMELLRNMSDIESIIRTFRSLGKLDLTEFLHIPDNHKTLMTIKNNVDRMKRMTNNSKHRFHTPQPFKTMPRIYNHHGDSLNQSIANTNCTGRTKIVLPALKPTYGITRIEAPQYFEDSQQAIDCLIKTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSP9</accession>
    <name>A0A194QSP9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_12260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QSP9">
        <property type="interactions" value="791"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSP9"/>
    <dbReference type="InParanoid" id="A0A194QSP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="978"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="819"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ08507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1306" mass="149483" checksum="64D2602C1D66F056" modified="2016-10-05" version="1">MNFEFSIPLQKDELLESSSGQYHVEDVVQPRILLSKLQDAARAYNSDGVEYILEHFDTYFSVIVHGTKLEWNVINKVYEHILRTVKCLCNQLEVIFQEQEIATETRCKYLNIVKMVMYLFTEIMKTKDAKLTADNSTKLTLGKKGKAKNTDEEFCGWTESDKLEALVALHMLVQQPLSRLWDPPLAEDNFVVMVAYPCYKALEEQIIKNKTVRDTVFQVLGVLVKKYNHGTACLIKLVQSYTLRITVLGMMCEVVSVELRGEGLGEEQRVQRDDFLDDLYDHMHDLSAYVRHKVLQFWSRLQRENNVPVSRQHAVLERAIGRLKDKAALVRKAAIQLLKVFLECNPFSAQLKLDVLEEQLANEQKILDDLQKKLNPGPDPELIKKWDKIQNDVVDTIKEKMDTLTQDEPELSQATVENLYDAIRRSLKEKNYFKAYLIVKHTERQYPDAKLLRCDMPKSDQIDYFVALLRNIYIIPDRRQSISSTQQCDNEIALYKRVEEKESIVAFLQESVHFCRMISEAVPLVNSLLMSKQAGDVSEAIDFFTTAHHFNIESAKVGVANMLLLVWSPDQDKRESVERAYREMYLECDTRAERARAFTIAKNLVTLVTHVDLGSALALQHLIDKWVTKEDITPSIIQVFWELFLKKIDGTTDEDSYAALSLLTMISKAKPSVALANLEVIQTHGLTGDYNTRNFCVQLLSSLSKKEQRYPVDHSIMKSVFDSLMEVFNKFKKFTSFAANSIDLIYAICDTPDVLCEKLLVEMYKKIEKDPVKDKESEEEISVPLELLIRFVFTLGHIALQQLIYLDITVYSELRKRNQVREERKAEEKRKKKAGVGSATPARRGRCDDLRRQTLMNASNASASSRGQRSASVLSNKASTVNTTMTEEEAGLEGAVADDADAEYVRAVCERDVVAGGAALARYTPLLRWLLTNTRASPRAQAAAALTYTRFMLVSSSVCEEGLQLIVTVLKKSKNVSLRTNLTIAFADLTLRFPNLTQPWTHHIYDILSDEELEVRQCAVKMLSFLVLHEMVRVKGQIADMALCCADKDSRVTAMTRLFFKQLSQKGNALYNVMPDIISRLSDPELNVPEEQYRYIMKYITSLIQKDRQMEALIEKLCQRFKLSTEERQWRDLAYCLSLFTYNERSLRKLIENMDCYKDKLHCPGVMESFTALMNHTSKMAKNEIKALVTELGDKIEECFAVRDAEEGDRDGSDGADKHAAPKPTPRKAPRRGRRRSTSSSDEENEPPNKPPQTPQSVRKSRRKPATKNKTRAADSEDSDDDDFEKKTDDDVFKKPTTRKGTRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSW3</accession>
    <name>A0A194QSW3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSW3"/>
    <dbReference type="STRING" id="76193.A0A194QSW3"/>
    <dbReference type="InParanoid" id="A0A194QSW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14875" checksum="365A5B4A0FC67A55" modified="2016-10-05" version="1">MNTNSTEDRDEVDKAATIQAEHSLSSKEEQKSCKEAIPGTLPISADTLSAASRGLLMRLLERDPRVRLRSLRQLQQSAFYMSYNFEHVKAKKISPRSILEKYFPPGKFLEDGNIINATQHFPSFDQQTMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTA2</accession>
    <name>A0A194QTA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain 8, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_06241</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QTA2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTA2"/>
    <dbReference type="InParanoid" id="A0A194QTA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1953"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2234"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2561"/>
            <end position="2709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3183"/>
            <end position="3217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3403"/>
            <end position="3444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ08753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="4048" mass="466324" checksum="DAFAB2F465E8AD2E" modified="2016-10-05" version="1">MSDDVDKPAPENAETVQVEGAHASGDAEQKVEDVEHTAVKIDELSKKYSRERRPTVEAEDSDEERVVVDRTALEAILDVSSRLKDIQKKSRVSMSTLALGHESYKDKQAKAKEARNARMGGIKTQHRFLLENSAAIINKSPEYVLEGVFDADVHIDILDSAVAEGGRNCIVLCDALLPPLKMESGRFVPNQKTWMERVYLSDTSTIPVQGRCVAMYRIKNKAIDVKNVADDYYLVYIDISSEKDNVVSGIYKTMVQVYIPALKECQAWGDLNPPNPRSGDIIPSYISKIMLFIDYLEKTKIDLDCCTRFKINYMLYEDELSDQEKMKHAITKTNVLEEICKFVKQWMKQITMVLVQSQQLRREPSNIGPLAELDYWRRQLTTFTSIIEHIKSEACQMYIHTLIRAKSKLIKKWRLLDNQVTDYYNEANDNVKYLYALEKYCEPLYRCDPVTMHQHIPGLLYTVRMIFATSRYYNTTKQISTLLVKVTNQILNMCMDYLTNKGKKTIWNQDKQNFIKKARLCLSLYSFYRECYDETQKEMIAAADERPFDCSEMYIFGKFETFQKRLLKIIDLFQTYITYYVLNKTTLEGIEEYASNFNKLFKTISSKTYDALDHRRPDFDKDYKTYKDAVANQELLLENFMINSVNLCPTTEIALNLLKRFEKLKLDCLYLEDQYYDLIRNFTAEIENIRDRYNEERENPELPRNMPPVAGRIMWIRFYNKNIKLPMEEFKLHHEVITHMNTQRCIKLYNVMRIVFTEFELIYHSAWQENVGQVRLGLIAPLLIRHPLTNLYVVNFNVYIPECIREVEYMWQLGLNVPDAAQIVAYCKDRIFSNFERIKALVDRNNKIRRQVSMPKLYLPLLRAQLIKMEKAFQPGLSTITWTSLEIPAYCDNICEVMDEVDLFVKEVTDMKEARIDEILKSIATTMLVYLPENAVDPNLFYEENLVRRDEIAFLEIENPDRFDVTPTVNECNELFAYFATKCLESLIKCTRQSLDILRKRASVSSFLTMTTDPEEQKKLKPLMLTMMYLQIPRILIKPTLEEIQSAFSQVVLNCIMDIHRNVYMWGQQDQINKVKSVGASLTITRSMSGSRSASSLGGIRSYFRMVSEHKDIVRAVMALQGMMYMYKPDIEKLLQGYNRFAHLWAEDRVQQVQSFVDSNPLNVIIRDMLKKYESQTEEVVNLPPRHIIGSIQIDTDNLKLALHVESVEWKRILGKLLSQSYRERVLNLMQFIKDRMKTMSKKIKDLDDVRVAMMCLELIREEFIGMDMELDLIEESYATFSQFDIDIPKDDADMVYGLRYAFQNMLITSQQVQQKIVDMQGPLQLELTEGVDTFLNDVLKFDADYDAFGPMTPGLSAREASDRVILFQSRFDELWRRFEMYSSGEKLFGMEVKDYPILHQKKKEFNLLSKLYSLYLAVMNSIDGYLETPWVEIDIEQIVAQLTEFDLRCRKLPRGMKDWPAFIDLKNKIDDFNQTCPLLELMADKSMKERHWKRLEDLMHCVLDVESPTFTLANVMEAPLLKYKEDVEVVSDWAVVDLTFANFKNRGELLIKPQETLDIITMLEDTMMILNSLASNRYNAPFKKDIMLWINKLISTSDILEKWLQVQNLWMYLEAVFVGGDIAKQLPAEAKRFATIDKTYVKIMYRARDIVNCVETCTSDDSLKQLLPHLYDQLEACQKSLTGYLETKRLIFPRFFFVSDPVLLEILGQASDPHSIQVHLPSIFDAIYTVDFDDKERIVAMNSSNGEKIKLERAVVCLGGVEIWLNTLLDTMKDTVRNIIANISQTMSGDPEFEFLVGFWNFPGQASLLGMQILWTSDAEYALKKARADRFIMRLTNQKFLDLLNGLIDQTVKDLIPLDRTMIETMITIHVHQRDIFDDLVKMRIKNVGDFEWQKQARFYYIEDTDDCIVGITDVDFLYQNEYLGITERLVITPLTDRCYITLSQAIGMSMGGAPAGPAGTGKTETTKDMGRALGKLVIVFNCSDQMDFRGLGRIYKGLAQSGTWGCFDEFNRIELPVLSVAAQQIYICLTARREKKEFFIFSDGDVVSLNPEFAFIITMNPGYAGRQELPENLKIQFRSVAMMVPDRQIIIRVKLASCGFKENILLARKFFTLYKLCEEQLSKQVHYDFGLRNILSVLRTMGAQKRANPDSTEENIMMRVLKEMNVSKLVDEDEPLFISLIEDLFPGMKLTQTVQREMQRGITIVTERSGLVNHPEWNLKVIQLYETSLVRHGLMTMGPTGSGKTTCIHTLMEALTELGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRRALKVKKSDTTWIVLDGPVDAVWIENLNSVLDDNKTLTLANGDRITMAQNSKLVFEPDNVDNASPATVSRMGMVFLSSSVLKWQPILEGWLRKRPPREADVLRNAFNKVYDEVHTYVQQKLPAKMALLEAIYVRQCIDVLVGLLEIEIPGGKTHTDRHLERLFVFSLMWSLGAVLELDARTRMAEFMTKLPVKMDWPGSKSKEWVMPFEYMVTETGVWQHWSESVEDYIYPTDSVPEYASILVPNIDNVCISFLIDTIAKQNKAVLLIGEQGTAKTVMLKSYMQKYDNEVKLFKMINFSSATTPNMFQRIIESYVEKRVGMTYGPPGGRRMTVFVDDINMPVVNEWGDQVTNEIVRQMMECGGFYSLEKPGEFIIIADIQMFGAMIHPGGGRNDIPPRLKRQFNIFNCTLPSIVSMDKIFTTISAGYFCKTRFDKKIVDFMPRLVPVTRLIWQQTKIKMLPTPAKFHYVFNLRDLSRIWEGILYIKKEELPNITTALKLWFHECLRVISDRFTTFDDKDWFVENFWKIAAHELPDVVNDFPTEDTYFVNILREPVDPTGDEEEDFSTEAPKIYEELPSWEFVLKKLGQFQDQFNEQIRGAHLDLVFFHDCMVHLFIISRIINTPRGNALLVGVGGSGKQSLTKLASFIANFKFYQITLTRSYNVNNFMDDIKILYRTAGLQGQGISFIFTDNDIKEEQFLEFLNNILSSGEIANLFPKEEMDEILNELTPIMKKYAPKRIPVPDVLYEYFIMRSRANLHVVLCFSPVGEKFRSRALKFPGLISGSTMDWFQKWPREALIEVAQHFLSGFKAKETKTQLIEVMGMVQDDVASACTSYYDRFRRQTHVTPKSYLSFLEGYKVLYKDKHNNIAEMAKRMTTGLDKLVEAAASVDILKKELELKELEIKEATAKAEEVLAAVAESAAAAEVVKAEVLEVKDRAVKLVSVIAAETAVAEEKLAAAKPALDAAEAALLTINAADIATVRKLGKPPFLITLIMDAVIILFRKRIDPIKPDPDKQFLVASWAESLKVMADARFLNNLKNYPKDEINAEMVDLLQPYFNFSQYTFEAAKIACGNVAGLISWTIAMAQFYGVNKDVLPLKANLAVMQGKYQAAKKELEAAEALLQAKERELAGVQREFDQAMALKQAVLDDAAKCQQKMDAATALINGLSGERVRWTEQSTLFKAQIERLVGDILFLTGFLSYSGPFNQEYRNLLVSNWLSELLRRKVPVSMSLSITEELTDTATIGEWNLYGLPTDDLSIQNGIIVTKAARFPLLIDPQTQGKIWIKNMERLNDLIVTTLNHKYFRNHIEDCVSLGRPLLIEDVGEELDPALDNILEKNYIKIGSSFKVRLGDKEIDVTDGHKIYITTKLPNPAYTPEVSARTSIIDFTVTMQGLEDQLLGRVILTEKAELESERTQLIMDVTSNRRKMQELEANLLHKLTTIQGSLVEDVTLIQVLNVTKATATEVREKLDVAKETEIKINTAREEFRPVATRGSVLYFLICNMSLVCNMYQTSLAQFLERFDISMERSPPSPITIKRIWFIIDYLTFDVFKYICRGFYEKHKYLFTLLLTLKIDLQREYITFDEFQTFIKGGAALDLNACPPKPFKWVTDMSWLNLVQLSNLRQFTNILNQVNNNEKGWKNWFEKEAPEDEPLSGAALDLNACPPKPFKWVTDMSWLNLVQLSNLRQFTNILNQVNNNEKGWKNWFEKEAPEDEPRPDGYHTLDVFRKLLVVRAWCPDRTLAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUC6</accession>
    <name>A0A194QUC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUC6"/>
    <dbReference type="KEGG" id="pmac:106719196"/>
    <dbReference type="InParanoid" id="A0A194QUC6"/>
    <dbReference type="OMA" id="VRYNRFR"/>
    <dbReference type="OrthoDB" id="7405492at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264636" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="15070" checksum="EE741B6116A7D7C9" modified="2016-10-05" version="1">MHASLTLVLALTAHALAAPPRERAGFQREIDGTRYNQVPKIFDYVLSEDYLNSLRSKGKLVTKLRPEEALAADNVILESNVVSIVRPSKLKDSEEGVALVRQRRGYNLENVRVPARYPYLPVPRYNRLRRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUY3</accession>
    <name>A0A194QUY3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUY3"/>
    <dbReference type="FunCoup" id="A0A194QUY3">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUY3"/>
    <dbReference type="KEGG" id="pmac:106717516"/>
    <dbReference type="InParanoid" id="A0A194QUY3"/>
    <dbReference type="OrthoDB" id="10012356at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="7">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17461" checksum="B2EF0B8ECADE72C8" modified="2016-10-05" version="1">MATSRLERIGTIFTRVEGLLTRGAMKPDDRPLWFDVYRAFPPNEEPRFARPKPEVKKIRQILYKEDAIRSKFHSEGHGLGINMLNPSGETQTKRLLQQYEKLKSEGVPENELIEKSVAAVSVERQLASKTIPKNPDSVTAQVLGSADIKNIFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWL0</accession>
    <name>A0A194QWL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maspardin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWL0"/>
    <dbReference type="STRING" id="76193.A0A194QWL0"/>
    <dbReference type="KEGG" id="pmac:106716639"/>
    <dbReference type="InParanoid" id="A0A194QWL0"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="36177" checksum="2E89605467A5F58C" modified="2016-10-05" version="1">MSYMSDLSQSNEYLSFRSSIPLRKIVVDSDGSKAWRIFDSGPKSVRCPLICLPPVSGTADVFFMQVMGLASRGVRVIAAEPPPYWNMKEWIDGFKRLIDYLELDRVHIYGASLGGFMAQKFAELTRNCPRVASLVLCNTFTDTSVFEYNDSSALFWLLPSLVLKRMLMGNFTTDKVDKRIAESIDFMVERLESLNQSELASRLTLNCSPCYIQPHLLNDMPITIMDVWDESALSSRVREDLYKSYPQAKLAHLKSGGNFPYLSRSDEVNLHLLIHLRQFDGTELSSSYLSLVPQPKSGNNSEQASVSYFNQRDKFVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX67</accession>
    <name>A0A194QX67_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">STAGA complex 65 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX67"/>
    <dbReference type="STRING" id="76193.A0A194QX67"/>
    <dbReference type="KEGG" id="pmac:106716641"/>
    <dbReference type="InParanoid" id="A0A194QX67"/>
    <dbReference type="OMA" id="HTIQLHA"/>
    <dbReference type="OrthoDB" id="6021257at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="323" mass="36031" checksum="1F2C6E8C0C2394BF" modified="2016-10-05" version="1">MSKKLWGEFEDDDNDDTIQQTVNFNPIIELGMQNIPEIPITVKSSPIELPKANLITHTIQLHAYSRQLTAILEQTENAVFEGARLDVMSLPTPPPELSTELEHESKPPINFLQKEYCEFSRGKGPVITPFTPESHKRALRQCAAIALGHIGIATCTNTALNAMADALDLYLNNMCKLMRTIVDREASGIKSGFPDVMAKVFADLNVGNLHEFYQNRVIKYHAKIKRTCDDLKIQCEALALGELAQPLEEVPELHFPAALDDAFTPSLEPGFQMLQSLEQDQLQGLDILEAVTSDDIRVDHIDFSQPETVKISSLSPGARKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0D7</accession>
    <name>A0A194R0D7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cathepsin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0D7"/>
    <dbReference type="STRING" id="76193.A0A194R0D7"/>
    <dbReference type="InParanoid" id="A0A194R0D7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018630740" evidence="6">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="307" mass="35215" checksum="5CEAC57C7C243C85" modified="2016-10-05" version="1">MQYLAILFGLLHAVASFDKDIDLKYKTLPEADFIEYFNNLGLSWKITSKKFSDVSQLACSFLNSSFIKDIPYIKHEKDVDLPSDFDARKKWPECPTIGKIYDQELCGSCWTFGVATTASDRTCIHGKGIVNLSEQDFQCCQESHPGNVCQGGYPSVAFNCWTTIGLVTQQCQPYNILELMENKCERKCHNDADYESDKHFGANVYRIQKVDKAIKTELFENGPVEMSFDVYEDFLQYQNGIYEHKFGRLKGGHSVRVIGYGEENGVKYWLAANSWGDLWGEDGFFRIKRFQEEVYFEDEVLTGIPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0G4</accession>
    <name>A0A194R0G4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin-like protein costa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0G4"/>
    <dbReference type="FunCoup" id="A0A194R0G4">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0G4"/>
    <dbReference type="KEGG" id="pmac:106715001"/>
    <dbReference type="InParanoid" id="A0A194R0G4"/>
    <dbReference type="OrthoDB" id="540783at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="936" mass="106283" checksum="AE9A0999ED0CB93D" modified="2016-10-05" version="1">MDIPVQIAIRLKPPSIADSLQCIFSNPVTQIVITESGQTFHVNRALPVDCTQAHLYNSFMIPQINCFLDGCDTSVVVFGQARTGKTYTLFGPGFECIHSECDQGIIPRFLTDIFHKLSQMPEREFILHITWMQVVNNNIFDVLGAGLVRCCNVEEAFQYLQLGWRQRCLGNNHTVFTVSMEQKWVGTNGVLNHRMSTASFCDLSAYPEPSLFALENIIKELVAGNPPKQINYDQCILTAMLRDSFGGRAFTWVIGCISTEPEDYQDTLKILNICLCCRGIKNFVTVNLFADNNTPVYTEKSVLPADNSFNLQFATTQWIKLVSNAEGLFNKILQSKSLSETDMNQVSEWLFLKAECDECLNGDIGGDNKDVATKQGLPRIAEDTEPSEPSESDEESDSEDCHSETVFQDKVEKYMDYFREKNDQLFAERCEEYLNHIDSDDITISETSGSQSLPIMTSQSNSGRRRTIQPGESLSGAELELLRKVAAKAISPESQKIIIESHKKDVDPEPKLIERELLKMIDSPKTAEICKKYKMTKEKYAQKQILARKISKEISSSQTQLKELINLCIAKERLINDLTKAICINNPNKIYTDKFDSRLGDQDAIKEIKRHETNLKTYKKQIDQIKRQIKKDEKRRNTLDVELVKDKLKLDELSETSVDMKDKKVHSLKHFTNRITQLDSILKEKTQDLANLELSKDKELLLRKEIKNLRKTRECLHEQRCSLGHKRKIYKSLSDSEERKILECEEAIEAIDTAIEYKNNLICGKSPAASLSDSQENKDSRSRGEQMLMARLDKLSHDEMKSLLYRYFEKVVDLRGACAALEAGAAAAAAEAAAWRARAANAWRHAHRPRPPQHTRCLDASIINDRALSLGLTTDSETSDDAMRLVDRMRQLARYPTGPVIPSQNLRQLMPATNMPVAKVTKERNKLVIIQQNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R103</accession>
    <name>A0A194R103_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorion class A protein Ld2/Ld41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R103"/>
    <dbReference type="InParanoid" id="A0A194R103"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264825" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="16745" checksum="CF84BA23F3FF2C79" modified="2016-10-05" version="1">MTRVVLICFLASIIQISLCQVIANSPYYANVNNGYGLANTPIANTIAASPINGISPSISMASPIANAPMYATLPIENLGTGTAAINTANAITAGVTGLEGFSLGGIPMSGVSPMGYGDVTVLGELPVGGSTGVTGNVPVIGYVTFEGTVPAGGTVTLASNCGCSNPTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R183</accession>
    <name>A0A194R183_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R183"/>
    <dbReference type="InParanoid" id="A0A194R183"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="198" mass="21259" checksum="DAD559C8C22C34B7" modified="2016-10-05" version="1">MHQMNQMNHSMNHAINHQPINNQINQHQRNSPRPLERELKVRDDFESLKTSLHPHLSSLASLAQGAPLSAPSSVFALAGGGATGGFPYAPPAFLAPAPPPPAQPAGSASSSSSEGSAAGWSFEEQYKQVRQVANAAHRHPQLQMRCLSIIDAEWHSQKEDAYMSMGVDEHLGVPAARSGFACGVTLWYTMSGALTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2T7</accession>
    <name>A0A194R2T7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein C6orf105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09771</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2T7"/>
    <dbReference type="KEGG" id="pmac:106714224"/>
    <dbReference type="InParanoid" id="A0A194R2T7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="27272" checksum="8AE4FAFEA75AE43D" modified="2016-10-05" version="1">MLLPIFHFSAMAVDAYAFWYDQTYVDLPFSNPLVKELPLKSRSMFLTMWCLILQITYHMIAFLNDVFGTNAASPKKKPTIRLIKDVLFSIAFPVAMYVSGTFWGIYAIDKDLIYPDYIAKLYPEWVNHVLHTTIAIFMFIELLMTNRSYPSRKVGLSVMSTFIISYISFYLTVYFKTGTWAYPLFDELNWPLRIVFLLFSYLLVIAIYILAEKINYIVTGSKTEKTLSGKQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3G8</accession>
    <name>A0A194R3G8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA box-binding protein-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TBP-like factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3G8"/>
    <dbReference type="STRING" id="76193.A0A194R3G8"/>
    <dbReference type="InParanoid" id="A0A194R3G8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04517">
        <property type="entry name" value="TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000009">
        <property type="entry name" value="TatA box-binding protein-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015445">
        <property type="entry name" value="TBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="37328" checksum="2BD3E4C0607D5255" modified="2016-10-05" version="1">MAAANYTDNRYAWFNHFLINQAVGDMATLIQENGIKELSKGTHGVVTNHGISAHSVASHMVPDHEYCETAKPQEPQQPCVTSGEEVPMEATAEDEEETPEIDILINNVVCSFSVKCHLNLRQIALNGVNVEFRRENGMVTMKLRRPYTTASIWSSGRVTCTGATSEDQAKVAARRYARALQKLGFQARFQNFRVVNVLGTCRMPFGIRIISFSKKYKEADYEPELHPGVTYKLYNPKATLKIFSTGGVTITARSVSDVQSAVERIFPLVYEFRKPRTPADEELLRQRRARHAPPPAPLSTDLRLVTLSDDEENAAPPHANAEAHVDADADADAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3X2</accession>
    <name>A0A194R3X2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3X2"/>
    <dbReference type="InParanoid" id="A0A194R3X2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="10376" checksum="FD7BC5948A1983BF" modified="2016-10-05" version="1">MRSGERSPAGSCWLVLAGAGAGTSSAQTLIVKFPLYSTLTILCIEYKVMRRLVVTQEVTGRRPASATSSTLPRPVADVSSPSVGPCSSGAGSVVVPLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4E8</accession>
    <name>A0A194R4E8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4E8"/>
    <dbReference type="FunCoup" id="A0A194R4E8">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4E8"/>
    <dbReference type="InParanoid" id="A0A194R4E8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF233">
        <property type="entry name" value="ANNEXIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="352" mass="39077" checksum="EF2307EB06A69599" modified="2016-10-05" version="1">MSGQQYYPYKVSFPPTCKVILIAIHSIDSEVMMSSFRSKCTPTVYPAEPFDPAADAETLRKAMKGFGTDEKAIIDVLCRRGIVQRLEIAETFKTNYGKDLISELKSELSGNLENVIVALMTPLPHFYAKELHDAVSGMGTDEEAIIEILCTLSNYGIRTISAFYEQLYGKSLESDLKGDTSGHFKRLCVSLCMANRDENQGVDEAGAKSDAEALANAGEGQWGTDESVFNSILITRSYQQLRQIFAEYEALAGKDIEETIKKEFSGSIEKGMLAIVKCVKSKVGFFAERLYYSMKGLGTNDKTLIRIVVSRSEIDLGDIKQAFLDKYGKPLETWIADDTSGDYRKALLTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4X8</accession>
    <name>A0A194R4X8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4X8"/>
    <dbReference type="STRING" id="76193.A0A194R4X8"/>
    <dbReference type="InParanoid" id="A0A194R4X8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="643" mass="70964" checksum="1BAF545DB755ACB8" modified="2016-10-05" version="1">MEECKKRVHGTKVSKIANIFQGMPSRDDEDLRGADVTVVRTESHLARFNNARALFEKLGEENRGFRIEKSPSAAASFAGTRGGQPPVPTRSRSSSAGSVSPQRASVTPTNALAPALNGDRLANGAGQPPPKPVKPSVLPKPEKPDRRFNKELIEKQRNWTAHFNKQRPVRYEHEQRPDQKFGPGHIDRKSPEIAERYVVPSRVYSPPLSPGAGDSQAERPTTLPSSLVTRGVHVAKSPSPVKTIASVSPLPRASNTLSPTARTSPTFKVERVSPSKDGAQNIGINERLCAGSRSPVVSDIDSDTAESEAANVNNSVQYPNVPPKPVERILSAQSSPVSHSISDPLAKRPPPSPPIRMPRSPPPPIPQEKITPPRDTIPSEAFTEDRGIAFPDIIDDLRVQPIPPRNRRSPSKSPVPRPAYNDGSAPTSPLRRSADICDNARRSPSKSGDSEDENYNALQYGYDSNEKGKSKRRSSTPESPASALPEDDASRSPLTSPAASPVHGVPVTPSLLASPTHWYNKKEVKILNDRKQQFFVLAQWAVNYPKQCIGGRRLTYFWRSRGRRVQCNIEEVKVFESARELRLDPDLDGRAPPPPRLRRDAVPRPPSPRVPLRPAPQNYWHRISNIAIDYLYRMLLFHQTVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4Y8</accession>
    <name>A0A194R4Y8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4Y8"/>
    <dbReference type="STRING" id="76193.A0A194R4Y8"/>
    <dbReference type="KEGG" id="pmac:106713804"/>
    <dbReference type="InParanoid" id="A0A194R4Y8"/>
    <dbReference type="OrthoDB" id="7492107at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="328" mass="36825" checksum="9FDB90A142A23B3A" modified="2016-10-05" version="1">MELLSQVSNAQFLYPAAAVAVVLVCAALVFIFGFHSAEQPQFDKLPLVLDDRKSSNKKRKIKEKKSSPNRTAVEVKTKTETAKKSPAKEKKDEKPEKQKEPEKPKPKEKAAEPKPAKKEANDVKKGKKKPLVEVDKPVDFDEGVWEEVPKKSDKKKVKAPEEKDKKDSPTKKNKKKAKDADVEAARPAEESTEEPTKVTVTVETPLDEESSRALQAQVEEFQRVLKEAERRDQAALGNLEEDDAMDEEVPEVKDLRSNKKKENKEKQIKKKAVESAAPKSTPKGDDKDASDSSEKQDDIQNVPVFDELGDTWTDAKVSKKSKKKARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R512</accession>
    <name>A0A194R512_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R512"/>
    <dbReference type="FunCoup" id="A0A194R512">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R512"/>
    <dbReference type="InParanoid" id="A0A194R512"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000003">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="362" mass="42070" checksum="B14668EAE5F9BF31" modified="2016-10-05" version="1">MKAKSERRRPFIASQIDECRDASGLFYILPFQKGFLINWDTQKTVWDFIFSKECCPVNFSEAPLIITEPLFNFSSIQEAMTEIFFEEYECQSLLRINATDLAEYHYRKLNSNESTVVVDSGYSFTYIVPYIKGKKYKDGIRRIDVGGKVLTNHLKEIISYRQLNIMDETYVINQVKEDSCFVSQDFMADMEIAKKRGSENTIVKDYVLPDYTTIRRGYLRDVVKPDEDLEQQTLRLNNERFSIPELLFHPSDVGIPQMGIPEAIIEAIGACPEENKESLLENIVLYGGCTLFPGFRDRVYKEVRAFALDHYDVNVTLADNPLTYPWEGGKLLFKDPEFYSFCMTKEEYEEEGKSLAFERFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R548</accession>
    <name>A0A194R548_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUMO-activating enzyme subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R548"/>
    <dbReference type="STRING" id="76193.A0A194R548"/>
    <dbReference type="InParanoid" id="A0A194R548"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="236" mass="25768" checksum="C8CF88B298D7F225" modified="2016-10-05" version="1">MAGNIIPAIATANAIVAGLAVLRAQGILKGEIESCTSVYLRPKVNHRGQLFVPERTLTAPNPKCYVCAPKPEVALVCNLKQLTLKDLTAAFKEGLNMQAPDATVEGKGLVVLSSEPGETDHNNQKTLEEIGLNDGCALLVDDFLQNYEVRVRLQQEDEENSWRLVTDTDAPMPGPKEEEPANGSNGAEEPKPGPSRTNHDSDSDMEIIDEDDNGEPVEKPPKRRRKEMSDEIVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R562</accession>
    <name>A0A194R562_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ephrin-B2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R562"/>
    <dbReference type="STRING" id="76193.A0A194R562"/>
    <dbReference type="KEGG" id="pmac:106715236"/>
    <dbReference type="InParanoid" id="A0A194R562"/>
    <dbReference type="OMA" id="RVCCKPE"/>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02675">
        <property type="entry name" value="Ephrin_ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000054">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF29">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="9">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="260" mass="29354" checksum="C87E737A1AAE1203" modified="2016-10-05" version="1">MVSYGYFGLRQAPWTLLVLIFFVESVMGNYAKSFYIHWNTTNSIFRIDNTDHVFDLNKGNAQFEYDQVNIICPVYAPDTFEEDMEKYIIYNVSKEEYDSCRITNPNPRIIAICDKPNKLMFFTITFRPFTPQPGGLEFLPGKDYYFISTSSKDDLHRRIGGRCLSHNMKLVFRVCCKPEEQSPVPPPQPTLPPPPPPPTVPPTTTTTTTVKPVTKKTHKYDKTPNEVVKSEELSYSRGAALASSLALALAASAVLAPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5V2</accession>
    <name>A0A194R5V2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCR4-NOT transcription complex subunit 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5V2"/>
    <dbReference type="STRING" id="76193.A0A194R5V2"/>
    <dbReference type="InParanoid" id="A0A194R5V2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="182" mass="20517" checksum="1B1D908BD765F4DF" modified="2016-10-05" version="1">MSRNKDKHEGASGRQYRIMSDAERAAGKPGCWTALEVTGGVRALAPQLFQLTHLTELYLNDNSLQRLPPEISQLSALHTLDVSNNKLRSLPVELGDLIQLRELHLNNNYLRVLPYELGKLFHLQLLGLQGNPLSKEMLSIYNDSNGTAKLLSYMLDNLQGCGSLNHAIVKTELNRRLRDRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R668</accession>
    <name>A0A194R668_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM185A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R668"/>
    <dbReference type="FunCoup" id="A0A194R668">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R668"/>
    <dbReference type="KEGG" id="pmac:106712826"/>
    <dbReference type="InParanoid" id="A0A194R668"/>
    <dbReference type="OrthoDB" id="5984441at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="39938" checksum="509C2B65194FF97F" modified="2016-10-05" version="1">MYSLGRQCGLYKCLKILRLTFSDFCSLPDIKNLNIVRTVEKTIDNNTSIFIESPIHVKVQPIDVNDIGAHNKLTMTLYSEGKDASDFQVKQTSKRLELLNKNTSSDRNDVCIIQVPYKLNVQVTTTECASVFLSKLEGEEFVVQTERGTVNVADIKANNIKVDSKEGSVTTNGRLQASNIELKTGLNSGINCNNIMANSFNVTTHAGPIAVKSCYSNKSHFTTLMGNIRLDHLHRSVMIDVIKSGNLYITGFSGNLQASLKSGDVFMHASQLTEKSSIFIHEKGKVELLIPDIINNLPATNLIAEKITVDDKIMKLGRFMDDSHPKRFRFEKEPQNELHIVCKNGSIELKETNLPFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6F3</accession>
    <name>A0A194R6F3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6F3"/>
    <dbReference type="KEGG" id="pmac:106713207"/>
    <dbReference type="InParanoid" id="A0A194R6F3"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="282" mass="32452" checksum="B9A789BC1E381FAB" modified="2016-10-05" version="1">MTKCSFKFCKSVKPQHPKNDGMLYFRFPKHLIRREKWIEVVRRQRDEPSFEPNTASLVCSKHFNKGDFYTTGKGTSRLRDTAVPIIDPVNLNATTIEDENKLGDDICTQSNAVQTKPSTKKLIYQYSINTKDSSKNFDPINKMMKKDTSDLDMLFEENDNTKFSNYENPFLPSTSYNSGSSDNDEGIGKIIKIEFKESSNNSEEDKNDLDDNSIEDRNKMEFTRTRDLDKFGEHVAAMLKRIPLQRALDLQPRIVKLITSVMNDDDQTTVIEIEDELYGDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8Q9</accession>
    <name>A0A194R8Q9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8Q9"/>
    <dbReference type="STRING" id="76193.A0A194R8Q9"/>
    <dbReference type="KEGG" id="pmac:106712464"/>
    <dbReference type="InParanoid" id="A0A194R8Q9"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08602">
        <property type="entry name" value="GDPD_ScGlpQ1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265000" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="41"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="41805" checksum="EC7B31EE4DAB47A6" modified="2016-10-05" version="1">MANTFRAWLLLIAVGSFTFVSSAPAAISTTRTKSRVDKCKPLVIAHRGASGYVPEHTLGAYALAITMGADYVEPDLVMTRDGHLVARHDNELGLTTDVAMRPEFADRFKTKTIDGHEMSGWFTEDFTLAEIKTLRAVERIPETRPGNARMNGIFQIPTFQEIINLVKSLEISQQRPIGIYPEIKHSTYFQRLNLPMEDLVVETFRKNGYTGASAPVYIQSFEVNNLKYLKTITDLKLLQLYESNPSDQPYDQVVARTGLTYADMAMPDGLKKVAKYATAVGPDKSYIIPRNQDNTLGEPTSFVQDAHAAGLKVHPYTFRAENTFLPSEFRSKNPSKAAIGDLYGELRAFFATGIDGLFSDQPDKPVAIRENCIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8S4</accession>
    <name>A0A194R8S4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8S4"/>
    <dbReference type="FunCoup" id="A0A194R8S4">
        <property type="interactions" value="1534"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8S4"/>
    <dbReference type="InParanoid" id="A0A194R8S4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="35"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="154"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="784" mass="86424" checksum="26BE836158CAE7E7" modified="2016-10-05" version="1">MYKLRHLFKIRNSLNTQHGLRYNHAGVKTDLQLRNIDKVLIANRGEIACRVMRTAKKLGIRTVAVYSDADKHAMHVEMADEAYHIGPAPSAQSYLNANKILEVAKKSNSQAIHPGYGFLSENVEFCEKCANEGVIFIGPPPSAIRDMGIKSTSKAIMSSAGVPIVKGYHGEDQSIERLLAEANKIGFPLMIKAVRGGGGKGMRIAMTEDEFLSQLESAKRESLKSFGDESMLLEQYITDPRHVEVQVFADMYGNAVHLFERDCSVQRRHQKIIEEAPAPGLSEETRHALGSAAVRAAKAVGYVGAGTVEFILHRVTHDFHFMEMNTRLQVEHPITEMITGTDLVEWQLRVAAGEPLPVKQEDIVRRGWAVECRIYAEEPAAGFLPRAGTLHRLTQPTPEEFVRVETGVREGQEVSVHYDPMIAKLVVWGKDRNQALAKTRRKLSEYQVAGLETNVNFLLRLSGASAFVSGDVHTAFIPQHERELFADTVLSEHTAIQAALGYLIQSQLSSTANDTWKGISVSSNAWRPNYQLRKTVNFKFNEKDMKVNVEYESAPNTYKVQVDEGEWRQVEATLTNTDLGLKLTTKVDDKTSNVGFLTYDQEVHVYDEHGQTVVHLPRPKYQTAASSESTSSANSAASPTPGVLERVLVNKGDKPTTGNRRASTGRPAASGGQRNGACCATLRGSPPPSTLLSTCKPVRPDAGRERPRLSPLVLANPRADPARIPYRSDGRRAPVPLALLRAVDLILSLETAEYQNKEARRTVGAPARRPAGVATRAARTPVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA34</accession>
    <name>A0A194RA34_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA34"/>
    <dbReference type="FunCoup" id="A0A194RA34">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA34"/>
    <dbReference type="InParanoid" id="A0A194RA34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="673" mass="78224" checksum="BDAC76182D2B6670" modified="2016-10-05" version="1">MQTILHHNGSGSAAYTSTLKRREVHRAITLHPVKDHRQMYRLHTYFKMQTILHHNGSGSAAYTSTLKRREVHRAITLHPVKDHRQMYRLHTYFKNLRIQELKERSLDLHRDIAASVQELGVDADKVEDYVLPGGEPLFPHKMGEDGYLGNNRILGAPISMNRFKADDVEDIVHFDFISKSIYSISHSNPKRRIESPLKEALDDVIREVMEIINAPSRQRGRVIDFNELLYGYTRLQPLHGADHALDLLLKYRRYRGRKMTAAVRRHAYLQQSFTGTEIRELPIGEPPPPEDPAILEQVEGVEYEDFDEPREQQGFLERLDVRGALESGLMRIHSNLPKVLQWSGGELEYPLYDRRIHFIMPLSGRQETFGRFMKNYEDIVLKTDQAVSLIIVLYLDSKNPLDYVNTQSLVKYYTDMYGKDIRIIQMGPTTFSRGAALTEGLKLCQDDDLIFFIDVDMMFNHLSLRRIRINTIKYTQVYFPIVFSEFNPDVVNGEDYNKFKDEILIADDDIEKFVEEEEETPKTERELADLKYSTEINDENGYFRQYGFGILGLYKCDFMRVGGFDLNIKGWGMEDVQLFETLIKSNLTVYRTADDSLVHKFHSVDCDKNLEKSQFLMCLGTKASTYGSDKHMAYYMLNHQEVLWPQEQHNDNEQDKTNAEDVDKKEVKEKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA72</accession>
    <name>A0A194RA72_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Circadian clock-controlled protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA72"/>
    <dbReference type="KEGG" id="pmac:106711492"/>
    <dbReference type="InParanoid" id="A0A194RA72"/>
    <dbReference type="OrthoDB" id="6591956at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265019" description="Circadian clock-controlled protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26299" checksum="1F2430772A870AC5" modified="2016-10-05" version="1">MYLLLLVVCCAVFEGYASNVPLIQPCLLGDSECLIKTNTRNALSRIGNGLPEFGIESLEPMQLRNITMGAYGFTLVFREMNIAGASKCNVEDIKLNFVHSTMAVTIECPLEATGSFKMSGSICFFDVNHVGNYIVKTDSIRTTVNSRIDTVYGADGNTYWNLSLLGYSYEPLENLHIGLGRLFVGEVTRASPLHNVVSNNWWPLVSQVAEPAVSTAINRFHDVLKTFFLRVPLAHLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAB4</accession>
    <name>A0A194RAB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAB4"/>
    <dbReference type="FunCoup" id="A0A194RAB4">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RAB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="838" mass="97076" checksum="82C36DB823E1C555" modified="2016-10-05" version="1">MRRRRRANNQLPEESDKRIAKTMMRRNAMTILECSSAWAFRWFHNAFYCSYCDEKFVDSLPLREHVIASHLTDPPTPRVFAKLTENNMLKIDVTSLNCRLCNCVCSSIDILKNHLTIEHKKIFNKNYSDGVLPFKLDQTGFNCQICFDLFSSFSKINEHMNSHYQNYICDACGKAFVSKSRFRTHVQSHEIGNFPCGDCDEILQTRAARMCHRLKVHKSGVRYACPRCPEVFTTYYSRAKHLVDSHAHQRRDYECTTCGDEENSASQSTSTDNVKWSRKRKLAEENVNAAIILEHSNTVVFRWNRGKFMCAYCPCTYTSVKEIRLHSEDHKNKLDVFFYNPEVRNKYPLRVDITDLCCIICNEKTENLEALKTHLSDVHNKTFNSNNISLVPFVLTNEKYSCVACGKYFETLMALFSHMNEHYSDYVCYTCGKGYSSKHKLQSHQKYHESGEFQCPKCDTVLASRVARDQHVSKVHGAKDSNVKWKTGRKLNDVRDNAAIIIECSNVCPFRWRWGQFICAYCPTSFGDFKGFREHVAKHSKTEEAPKLSRPVNTTKAEVSDLQCDLCSQKAKDLDELVEHLTNAHNKHIVKEYGIGITPFYLNGDKYICTQCGVHFDLFTKLNSHMNNHSTDHICYKCGKTFSSAIRLKSHLVTHELTGEGCKCTKCGETFANLKLRATHMSTVHKPKLRYRCTYCNEKFKGYSERAKHLQKVHDKKREHACHLCQAVFSTFNQRTRHIQYVHLKVKPFQCPVCPYRSSTKALMTNHAVKHDGTRKFQCDVCSKSYARLKSLREHMRIHTNDRRFTCEYCSSAFVQKCSLKSHIRTHHPKAVSETKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB93</accession>
    <name>A0A194RB93_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0605 protein CG18335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB93"/>
    <dbReference type="InParanoid" id="A0A194RB93"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF8">
        <property type="entry name" value="PROTEIN FAM166B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="33788" checksum="52BF6A450AACEE8B" modified="2016-10-05" version="1">MALDLVSIAQPHYIPGYTGHCPEYKYRIGDTYGSTTHKILLDPSVQHSERLVLSDRTSDDYQIFRPPQTDIDVVNARFRNGDPVYKHPMMPGFEGFLPRLNAHFGQRYTVAATEALSEFERTQLNQRAARNQLERVVDLQAGKGQPWDLADRFSATAEFKLPLVVVRPECAGILRDLPMDEPKLSPPSHSVSPYFMDNEDSEKYIKKGFTGHVPYGFQRFGESSKKLTNSALCDFSSNYRRRQSTEWAPVNVVKLVTMPNFRLDLFKNTFNMFASSNNNGNVVSFLCFYFFQFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REL1</accession>
    <name>A0A194REL1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REL1"/>
    <dbReference type="FunCoup" id="A0A194REL1">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REL1"/>
    <dbReference type="InParanoid" id="A0A194REL1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000062">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="12">
        <location>
            <begin position="648"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="647"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="724" mass="80452" checksum="7DE5F64D836BEC84" modified="2016-10-05" version="1">MSANKESSLVQGYIELNKFCQSGDYERALKSAGKILQIAPTEQKAFHCKIICFIQLHNFKEALAVLSNPKNAALAADLHFEKAYAQYRLNCPKDALQTVDNAPELTLALKELRAQILYRLEQYQDCYNLYRDIVKNTTDDYEDERKANMSAVVANLAALNPIAPTEQKAFHCKIICFIQLHNFKEALAVLSNPKNAALAADLHFEKAYAQYRLNCPKDALQTVDNAPELTLALKELRAQILYRLEQYQDCYNLYRDIVKNTTDDYEDERKANMSAVVANLAALNPNADLPQFEETTYELLYNAGSTLAMRGKYTEALPVLKRAEQTCVESVVEDGGTEEEAKEEAAIIRVQQAYCLQGAGREKEAAALYQGVLKDKPADQALVAVASNNLVVINRDSNVFDSRKRMKAATADGLEHKLTSRQRAVIVYNQAILAIYSNQPEFCKQCCVKLSRELGQESRAALVEAASLARDGKRDAALALLAKHPGTHTLAAAQILLAQGDRKAAIKLLEESEFKYRPGVVGALATLYCADGDYERASQMFLDVYQHYKNDTGSPALRSVWRAAGEVHQRAGRVSAAAQAHEALASAQPHDRRSRARLVKLLAPSDPQRARALAAQLPPIQLQGAIDIEALESSKWMMGAKVVKKTVQSKQEQSPGTPGSELGVTKKQKRKRKTKLPPNADLSKPPDPERWLPKYERTAYRKRRGVRRDVIKGSQGMTTAAVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RES0</accession>
    <name>A0A194RES0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 Q2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RES0"/>
    <dbReference type="FunCoup" id="A0A194RES0">
        <property type="interactions" value="2052"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RES0"/>
    <dbReference type="KEGG" id="pmac:106710068"/>
    <dbReference type="InParanoid" id="A0A194RES0"/>
    <dbReference type="OMA" id="VFPKNHE"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000006">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="204"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="42590" checksum="108888442088B733" modified="2016-10-05" version="1">MACLNTLKLEIKTLEHVFPKNHERFQIMSASVDELTCRFVGNNGKKYEIHANITETYPTTPPVWFADSEDPIVTNAVQILSNTQGRDNHVINQVGILLRELCKLHGVPEPPDLDSLALPVHPAPQQRVPSVTSNGAESGTEEDEEMAAEEDDSEGEEDLPLEMVDDAGRSNKDEMETEHLATLERLRQNQRQDYLSGSVSGSLQATDRLMKELRDIYRSHSFKNNMYSIELVNDSLYEWNIRLRSVDPDSPLHNDLLLLKEKEGKDSILLNIIFKETYPFEPPFVRVVYPIISGGYVLVGGAICMELLTKQGWSSAYTVEAVIMQIAATLVKGKARIQFGATKVVSQTQYSLARAQQSFKCLVQIHEKSGWFTPPKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF27</accession>
    <name>A0A194RF27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein subito</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF27"/>
    <dbReference type="FunCoup" id="A0A194RF27">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF27"/>
    <dbReference type="InParanoid" id="A0A194RF27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="59"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="554" mass="62172" checksum="D64EE9E0F3D80DC9" modified="2016-10-05" version="1">MTHQRISDNDVSDCESDVPSFIEARPPLIMNPFMRPKPQKGTNLMDLFEKDSESDEPELVQVYLRLKPCNAPSNLYEVKSDHCLITSLDTSTVGHGRRTQYNVSKMYTFSHIFGPEANQMELFERVVKDNLKKLPEGHSFTLLTYGASGSGKTFTLMGTVSSPGLVPRSLEYVFRVVDAALRPVYKPADNGAEKLSYASQEHELQFVKQLRQVSAPLRERYRRMSTKLHSDFAASNLDLANRIKYYVWVSFVEIYNEGIYDLLSNNDRSSASKLVIREDSNGNVYVKGATQVFVKTGEEAYDVMVAGKHNLQVAATGVNARSSRSHCIFTITMLTETEAGCRVSSVRLCDLAGCERARRTRNAGARLAESRAINTSLHVLERCLRTLRQRQRQRARTDALPPLPPYRESKLTRLLGAGLSGARGEAVSVVVTVNPAAECALETRHVLQLAAVAKDIQVNNTVSEYSALEASSQDTMLSQSSSASSSELQRLRAENERLHFELLQAQEYSKELTMSMEEQRARNATNMKAIFSEGQDITRQHYETLMRAVRQEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH03</accession>
    <name>A0A194RH03_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH03"/>
    <dbReference type="InParanoid" id="A0A194RH03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="99" mass="11337" checksum="35000798EA991ADA" modified="2016-10-05" version="1">MYPRDIIRGNFTLSTRSEVIARWESPHVDTILVVRHSAPVRTKRECIAEREVACPPPQPRRAAHRPPTRPLAPPTRPLAHTQARTSLYALTNTNQRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHE5</accession>
    <name>A0A194RHE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase mitochondrial 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHE5"/>
    <dbReference type="STRING" id="76193.A0A194RHE5"/>
    <dbReference type="InParanoid" id="A0A194RHE5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19929" checksum="2DB8E40DBC7D3F7C" modified="2016-10-05" version="1">MFARVTFYPTLLYNVVMEKLIEEENIKGVVSMNETYELKIFSNDAEHLEKQQIVKSLSRQVMAQPKPPKDLNGSLTRFLRYIKTSIATAIQPNSNHIAHTQPAHGSESVRISIEWIARVSPRDHTIRSLQTTTSARANRTPRTHGLPELPQETPISTGLRLRNNCWYGRTQYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHG8</accession>
    <name>A0A194RHG8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">fumarate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08764</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHG8"/>
    <dbReference type="FunCoup" id="A0A194RHG8">
        <property type="interactions" value="1298"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHG8"/>
    <dbReference type="InParanoid" id="A0A194RHG8"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="462" mass="50766" checksum="B6C328C695D0F6E6" modified="2016-10-05" version="1">MACTTCMNPEGKPVKMRKEKDTMGELDVPDDKLYGAQTVRSVMNFPIGGIEERMPYPVVVAMGILKKAAAKVNMEFGLDKKIAEAIMQAADDVISGKLYREGHFPLVIWQTGSGTQTNMNTNEVIANRAIQILGGTLGSKDPVHPNDHVNKSQSSNDTYPTAMHVAVAMELRDRLMPGLVALRDTLEAKSKEFDKIVKIGSYLTKKMGPICKHYLSIEIFFIKIGAPGAELRGNKHKKKYSERPYACDLCPKKFMARKDLRNHRMIHTGEKPHKCQLCNQAFIQKCALNRHMKGIPFETAPNKFESLACHDAMVEVSGALNTIAVSLMKIANDIRLLASGPRCGLGELMLPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNHVACTIGGSNGHFELNVFKPMMVANVLRSIRLIGQYLAAAIAKTAHKEGTTLKDAAIKLGHLTAEQFDKWVRPEDMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHS2</accession>
    <name>A0A194RHS2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHS2"/>
    <dbReference type="KEGG" id="pmac:106708922"/>
    <dbReference type="InParanoid" id="A0A194RHS2"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF58">
        <property type="entry name" value="AGAP000074-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="781" mass="87361" checksum="3FE9891EBADD7934" modified="2016-10-05" version="1">MADPKVAHKEVMEEIVNRKKLGDKKSHSETSLQNLEDIDESVVTDAGKDPGVVNKTLNVVTNEDDGGDRRRTMSTPGPVSGSLLTATAARAARRRPPRSVMYAPDLERTDSTSKRDDDSILGTPIGERNSASPVLYNGNIRNNGDAKSLSSYRVYNTLNDVRGGTTPRKRSVTTMDAQSLRSLDTQAPPPTSPEDNKKLTLKYMTLILSGMYAILLVTLGVIFNLADPFVDMHLATIYSLVLTGVGFLYVMYLLFDIARYKGNALKNQKAKEIHEEKLSEYYRKREEEFGPIVAGDRTPDSYRSLKIPSALLVSLKHDYCFSQGRHSGSFYLKLGAAGFALGHLVHSVLLITLQANYYLDDNINNQDCVDVLRLVLDVVNPLYSFVQLYFIFKYSNVIILRGQGLAHFGFMHMIGSSLCFWIATIVRETVLALTLYANSKYGNRTNGYEAEINLDPVFTSAESRIFDISNLYNEHCQGSGAISSVFESVSPYLYPFSVEFNILIVAVYYIIWSNVGHCENADGDKSESNSSLGENYSICKIPTANEENDYTSNMVIYADCHASNRGLFVGLIIIVIVLGMLIVGFVFSSVGDNFLEVGYLLNYCTKLGLHVIMLFAAVIAYNQTIKLDINEHPISLLDDVLLFICLPAFFLESVLSLAATVSVENIIKSVDFVVMVVQVIIQTFLLVDGLRRCSNSRKLRRTKPGRELMMFMIIANVAMWLHYSFSYKSPDSLDERYEFYGKILWSILGHISLPLIMFYRFHSSVCFADIWNSAYKPGSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHW3</accession>
    <name>A0A194RHW3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Odorant-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHW3"/>
    <dbReference type="InParanoid" id="A0A194RHW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265210" description="Odorant-binding protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34049" checksum="D8947437F94204C7" modified="2016-10-05" version="1">MIRLFSFVTLFILVTKADVFVQAPNRGATLKPISVCCDIPEIGDPKHLAECSNPRPIGPCNDVQCVFEKSGFLVDENTLNKESYKKHLLKWLEDNKGWTGAIEKVINECVEKDIRQYLDYPCKAYDVFACTGIAMLKISTSQGPPPLPPNLPPECLNPPHIENPRKCCQIPPIFTKDEFESCGFKEENVDKPRHGPPDCSKQLCLLKSRNLVKDGDKVDHEAMISFMDKWVEANQDFKPTVESAKTKCLAQEIPGPMEICEANKIVFCISSVLFTECPKWVTGDDDCKKLRDHIDTCSKYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI94</accession>
    <name>A0A194RI94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine zipper putative tumor suppressor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI94"/>
    <dbReference type="STRING" id="76193.A0A194RI94"/>
    <dbReference type="InParanoid" id="A0A194RI94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="388" mass="44334" checksum="0915A0CD056B3111" modified="2016-10-05" version="1">MIQWRLSTDTELKQGSDMPLHITKTSCLASGDSKEPVPAPSPADSGVSELERDHHDYSTCERVRGHVHGHEARVRVARGLAAGVGAACARRDEREAELGRVRRERALLRQRLEDAEWSLCQRAGEIALLKTQLKEAQRTKLRAGEIALLKTQLKEAQNEQTAKGHEYLTMKADCRQLREALDKKEKDIMRLRSELEEKEKSVSRLQSEVDRLTGDLVQSVADMNKAKENSKNEIERLKTELKELRQELSDVSLSGYEGIECGRTMRGLYDCKTNEYHWNSSDSALEDAEVQRLNGELPDACGEPCPANAIVDRLKCELEAKEAQFNNERRKWSEEKDKVLRYQKQLQLNYVQMFKRSRSLEAEVDGLRLELELCNKNNMNQHGKTIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJV8</accession>
    <name>A0A194RJV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit TOM20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJV8"/>
    <dbReference type="FunCoup" id="A0A194RJV8">
        <property type="interactions" value="1596"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJV8"/>
    <dbReference type="InParanoid" id="A0A194RJV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17250" checksum="1321F9954B97B6CC" modified="2016-10-05" version="1">MEITRATLGIAVGIAGTLFLGYCVYFDQQRRKDPLFKKKLRERRQKAQQNASRSRTLGGPLPDMSDHEAMQRFFLQQIQLGEELLAAGDLEAGVEHLGQAVTVCGQTQQLLSVLQQTMPAPIFHMLLKKLPEVSERLRASMKANSSSLHEDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK64</accession>
    <name>A0A194RK64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK64"/>
    <dbReference type="InParanoid" id="A0A194RK64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="23092" checksum="214F5A261C1D0407" modified="2016-10-05" version="1">MSTIAEKLCGDIVNPVLEQSSASSHYTDISKSQDASPTRSILIEKRKVVNNIIPKGKSAVVITKFRSRETVYNKVFTDKSINTIISGPLTSNIECMTNIRKRATCTCGRVMKPLRNDVKNVQTSKIQLCQADKSCYYCSGTESCITRCTQFSDVSETVKDNNSLRSYQISENPGTSRNRTCRPVYIDSQSARHWALTKYPKRGPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL86</accession>
    <name>A0A194RL86_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL86"/>
    <dbReference type="STRING" id="76193.A0A194RL86"/>
    <dbReference type="InParanoid" id="A0A194RL86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ18184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="17299" checksum="D0EF819FE87C89ED" modified="2016-10-05" version="1">MAFKAKSAAYLQRVQANPAEMPKIDWEAYKKLIPQSNIVEKFKSDLEKYKVPYPQDNVTSQIDAQWKTIEKDVQQFCAEQQKHIDAASKELKRIQALPKFEDMTMEMFYYLYPERAIDPVNKPTFWPHNPEEQPGYVTPEAKTSKSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMQ5</accession>
    <name>A0A194RMQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMQ5"/>
    <dbReference type="InParanoid" id="A0A194RMQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF17">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="335"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="465" mass="53394" checksum="970241EB828B9B0C" modified="2016-10-05" version="1">MLQQILRDMWVDPEILAELDETQKQTLFCKMREEQVRRWRVWDDKVSKEVTDKPKFEANGKKHVQFLKGEDGEPWVWVMGEHPDDRSIEDILAEEARQRALSQACQEAHQLRKSVEKELTHLIEFQPLDTLEQKFDLSPKNVDSLEDTLDLYCSVDELRARMEELGPMPSPKDLDKAEFDAMKLDLNKNTMHFNFIEGKRDVRDVIQESGVGVGDGVSLRVAAWERRVAAARAGDILRGLRARRARTLRDAQRTTQHMDAVWREQERKAKEAEAAMREIARAAREAHRLSTEIDPPPCPSQAGRPPNREAVLEWFKTHELKKGVGLDEDNKPVDWFHGLISRSEAEGLLVCCEVGSFLVRVSERVWGYALSYRAQDRCKHYLVEAERGYRLLGNATITHNSLVVDPATIFVEPGLPVKYHDHTEDRRQVEAIRTDLIKHHKKVAITESGGEVLTTACPPQHPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQA8</accession>
    <name>A0A194RQA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQA8"/>
    <dbReference type="STRING" id="76193.A0A194RQA8"/>
    <dbReference type="InParanoid" id="A0A194RQA8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="13188" checksum="16AED510BB8BA9D4" modified="2016-10-05" version="1">MMGENEMGYGDYYNYDNSWPVAPPDYGAGLDPSCQYRQPEEDYRYGTYAVSLAPYNMTSRVGRAVTFACPTPIARPPVAEYHRARNPSAAPSQPSRAFEPLIGLETLFADSRATDHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRR2</accession>
    <name>A0A194RRR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRR2"/>
    <dbReference type="STRING" id="76193.A0A194RRR2"/>
    <dbReference type="KEGG" id="pmac:106710826"/>
    <dbReference type="InParanoid" id="A0A194RRR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="35161" checksum="7B9DB212EBFC0031" modified="2016-10-05" version="1">MSIPPVNYNIPPPSLNVPPPVPPPVVPIVPPVPPPQYYNHPPPYGANISQNVQPYLNMPSGLPPLNVPPPVSYRPSTEVSVSFPVPTNPSSYPYRQLGYGSHDRNAYNKYKTEAVSRTSNDYGSKERHSGSSKNHPKDVPTSSRSRYSRRESSYERERSYERERKRDRDHSFERRKDREFKEAKYRELRRSRSPSRYYDRCRDRERYIDHRERDRRYDYKRSHSPYHRDYRSHSRSIDSRDSRRDRRSPSRLSERSSRRESHSHSRARDRSPSYYHDSTPKRPLTDREKILEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RUH7</accession>
    <name>A0A194RUH7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RUH7"/>
    <dbReference type="FunCoup" id="A0A194RUH7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RUH7"/>
    <dbReference type="InParanoid" id="A0A194RUH7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="22625" checksum="FD9603F5ECA0608F" modified="2016-10-05" version="1">MSLFGEIVEPASRTIWEDWDDVLPESDDSKLQWQNKIEISQDIDTFYFIDGKYLNYFIDLQSQQLQLINEIKELNLRLYKIKLLNKYLCTIRDYDIVLSSEIVQLLEPYLESCKNVMTIQTIPISEYRSTQFHVQPCVIRGLYTSEIANKSEFEFPKLEQPNIISGVAAGGKNKYLMDPKYYICRDVYYDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RVZ7</accession>
    <name>A0A194RVZ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mutant cadherin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RVZ7"/>
    <dbReference type="InParanoid" id="A0A194RVZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36979" checksum="D70806D68323AA9C" modified="2016-10-05" version="1">MSSNVVKCVNCNVVINELLAFVNNKIAVMDDESIIKICTSSFSEEDIVVAKNLLFDSLPKRRRKIIRKKSGKSLRDIDDIVCLLRDTDPEEIPVFVAKDLEKLPPVLFDHVDVTRLLKDIVKMQQDIKDIKQGYVTMDHLKQFQSELNIHKQSCALNNYDRNVNIRRGAGCLLDSFERHSGPMGLPPVTRTDNEQHELYLQNTNYCNIDHDICSYEGSHNSPQLEFCKQNNVAATTAMTHTNESSERLPPPIVCESKSDNSRHTAASRGEQCNAQKIKSTAEVVKGGEWKQQKHSDDWIKVQRKRMRNRFMGKTGRDNYTTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBB4</accession>
    <name>A0A0N0PBB4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alanine--glyoxylate aminotransferase 2, mitochondrial</fullName>
            <ecNumber evidence="28">2.6.1.18</ecNumber>
            <ecNumber evidence="12">2.6.1.40</ecNumber>
            <ecNumber evidence="5">2.6.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(R)-3-amino-2-methylpropionate--pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-ALAAT II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-alanine-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">D-3-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">D-AIBAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">D-beta-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="ORF">RR48_02100</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">Ya'a_city_454_Pm</strain>
            <tissue evidence="40">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="38">Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77339"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:18393"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.40"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18394"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77355"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77363"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77359"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>3-oxopropanoate + L-alanine = beta-alanine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:14077"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.18"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:14079"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77331"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77327"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77315"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77307"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:77351"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77311"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:77343"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77303"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77323"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77319"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>oxaloacetate + L-alanine = L-aspartate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77347"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 39">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="28"/>
    <dbReference type="EC" id="2.6.1.40" evidence="12"/>
    <dbReference type="EC" id="2.6.1.44" evidence="5"/>
    <dbReference type="EMBL" id="KQ460971">
        <property type="protein sequence ID" value="KPJ10138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBB4"/>
    <dbReference type="FunCoup" id="A0A0N0PBB4">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBB4"/>
    <dbReference type="InParanoid" id="A0A0N0PBB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047305">
        <property type="term" value="F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine:pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019481">
        <property type="term" value="P:L-alanine catabolic process, by transamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000055">
        <property type="entry name" value="Alanine--glyoxylate aminotransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF3">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 40" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 40" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00044055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00058068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KPJ10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="459" mass="50760" checksum="E1EFD8F860E4D2BA" modified="2015-12-09" version="1">MKMPKCDFKPKKYTGPSVAKTEQIKSTNIPPAVYNIYKKPLVIHQGHMQWLYDHEGRRYLDLLGGIATISVGHSHPKVAAALKEQIGKLWHTTNIYRHPKIYEYAEKLIAKFPKKLEVVYFVNSGTEANDLAVVLSRMYTGNVDIVSLQGSYHGCSSGLMGLTSTQSFRHPNISLAGYYHAMVPDPYRGIWGGCRDSLSQVPGACSCPGDCVTSDKYAHQLSELLNHSVPSGRLAAMFAEPIQGVHGNLQYPKGYLRKAREIVKKNGGLFVADEVQTGFGRTGDTFWCFESEGIVPDIVTMAKGIGNGFPLAAVVTTREIADAHTRTSYFNTFGGNALASTVGKAVLEVIEEENIQENSKTVGKYFLEQMMQLQKQYPIIGDVRGKGLMIGLDMVKPGTKEPIDNGAEIFETIRDLGVLIGWGGRWNHNLRMTPPMCINKEDVDFAISVLDEAFKRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCC3</accession>
    <name>A0A0N0PCC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCC3"/>
    <dbReference type="KEGG" id="pmac:106712609"/>
    <dbReference type="InParanoid" id="A0A0N0PCC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calycin"/>
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    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15513" checksum="40EE02E8EDD52555" modified="2015-12-09" version="1">MSFYGKVFAVESQENYEEFVKSMGLPEEKTKSLLEYKPSQKIEKNGDEYTFTVYSKNGEKVYKSKSGEEFADTFKDLPVKIIFTVDGNKVKQIIKFDIGFTLTIKKEYFDDKFIEEISHSLWDGVARKVYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCL4</accession>
    <name>A0A0N0PCL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCL4"/>
    <dbReference type="InParanoid" id="A0A0N0PCL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="69" mass="7402" checksum="3A999E0E0959DA3F" modified="2015-12-09" version="1">MPTTPAAAAAPASRSCVLLSVVLPVSRVRRASLSPITAPPRCPHRDQLTGRFALLAIVCAVWLCLFRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD21</accession>
    <name>A0A0N0PD21_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">mRNA export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_01941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460480">
        <property type="protein sequence ID" value="KPJ14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD21"/>
    <dbReference type="FunCoup" id="A0A0N0PD21">
        <property type="interactions" value="2519"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD21"/>
    <dbReference type="KEGG" id="pmac:106711587"/>
    <dbReference type="InParanoid" id="A0A0N0PD21"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
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    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
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    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
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            <end position="107"/>
        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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            <end position="29"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="39042" checksum="F7EE4D070875F3FA" modified="2015-12-09" version="1">MFNQLGGGTNNPNKDLEVTSPPDDTVSSLEFSPPSVQQTFLVAGSWDCRVRCWEVEISGKTVPKAAQSMDGPILDVAWHDDGSKVFMASTDKSVKCWDLAANQCVQVAAHDAPVKTCHWIKAPNYNCLMTTSWDKTIKFWDTRSAVPIMTMNLSERCYCADVEYPMAVVGTADRGICLYTLEGKPAEYKRVESPLKYQHRCIAVFRDKKTKQPTGFALGSVEGRVAIQYVNPVNPKDNFTFKCHRAGGGTSGSFQDIYAVNDIAFHPVHGTLATVGSDGSYSFWDKDARTKLKSSETLDQPLTKCAFNHSGQVFAYAVGYDWSKGHEHYNPAKKNFIFLRPCFDDLKPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE05</accession>
    <name>A0A0N0PE05_PAPMA</name>
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        <name type="scientific">Papilio machaon</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Ya'a_city_454_Pm</strain>
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        </location>
    </feature>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18475.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15442" checksum="01CEFDE3579B4942" modified="2015-12-09" version="1">MSEENKLKITALNTTSNINTLIRDIFRTPPSFKSKVQLSFHTKKSEKEALTVQSDEKETESAGQKRHQPITFDKGDNMSPEKRARSGDRNLKMYTPPSGKYSSRFTGNYSGRGRGGYGRRDFRNNGAPFRRRSNY</sequence>
</entry>
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    <accession>A0A0N0PE94</accession>
    <name>A0A0N0PE94_PAPMA</name>
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            <taxon>Papilio</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CUPIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="231" mass="26501" checksum="52A4AA6BE70EE6F0" modified="2015-12-09" version="1">MAAAAVSRPDNEFQFHTHFTRIDSRLIGLGLTGRLQISRELSGRCTLEIPSTSLTLFRPPEDCSMCDSVSQVARLGNLTPEEFERRFAYSPTPVIVTDATRHWKAIKEFNFNFFADFYRNGKMGNKINECFFFAYKSGLRSLGEVMSMDAARANLSGAPWYVGWSTCYDEETRRLRQYYDRPYFLPRTAESDTIDWIFMGGPGQGAHMHVRFMFRTGIPKTFFNFTGLVNP</sequence>
</entry>
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    <accession>A0A0N0PEL2</accession>
    <name>A0A0N0PEL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein MON2-like</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PEL2"/>
    <dbReference type="InParanoid" id="A0A0N0PEL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2 C-terminal" evidence="2">
        <location>
            <begin position="486"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="720" mass="79248" checksum="C8328B670A8FAA95" modified="2015-12-09" version="1">MLAELYKNMNSNVLLEGLTSLNISVVSIEMLDRTEAPTIQEGYGISVAYACLMEIIRSIAISVEGDEYFRLQELYEDIQNDSEEIITNKNGNNNKELESTTESTEISNNGHRGEPDQNSNVVQKINPEIEEKEKLVMLQLIKSSWCGLVWGLSVLAEASIGELENILCAIQTLARVSGKVGVSGSRDACVAALCRAALPAQYCVPVLGALGALACPWAPAARAPHPPAPDLRHHVVWVGTPLPCAQLPTGQQQSFVMVTSRHVTAMKALLNAARRDGDTIQQAWLPVLTTLQHLVWILGLKPSTGGSMKASRASADANAVMSTSAVMADLPGQQVPVAESLGVMSALSAMLSRVFESSKNLDDVALHHLIDALCKLSNEAMELAYSNREPSLFAVAKLLETGLANMHRIEVMWRPITNHLLEVCQHPHIRMREWGVEAITYLVQAAFQYHHNNPALVTECKLTCVLCCSEQLVRSAFQCAQLVAGDLLGCAGPRCLRRVLAAAAAFARQTKELNISLTAVGLMWNISDYLYHNRDKLSAALASDPVCPELPHHADLPPLDKLWMCLYIRLSELCTEARAPVRRAASQTLFSCIGAHGTLLSKPAWRALLNVLFPMLEQVQKQSNIASSEKVDTGEHILIHHTRNTAQKQWAETQVLTLSGVSRVFHSRFQLLTTVGDFQRSWAALLDYITDFALRRSHEVIFSSYLHIQNSLCNQLSYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFJ3</accession>
    <name>A0A0N0PFJ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01125</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="LADJ01036943">
        <property type="protein sequence ID" value="KPJ21304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFJ3"/>
    <dbReference type="STRING" id="76193.A0A0N0PFJ3"/>
    <dbReference type="KEGG" id="pmac:106707481"/>
    <dbReference type="InParanoid" id="A0A0N0PFJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ21304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="511" mass="58803" checksum="D65774136249BDF9" modified="2015-12-09" version="1">MLTLAVVFLLCVALYFYGTRTFTYWEKKGIKHDKPVPYFGNNSRMYLWKKSMTQIGVEMYRKYPKEKVVGFYRAMRPELVVRDPEIIKRILVSDFGHFHMRGINTHKKVIEPIAKNLFLAEGDLWKLLRQRMTPAFTSGKLKAMFPLIVERAERMQNHAINAPPTGRVLDSREIMARYTTDFIGACGFGLDMDSLSVENSSFRKLGIDIFKIEISQIIKQMLKEMFPEACKHFRIFRKIENDANALVKSILKKRNYEPCGRNDFVDLLLEYKKKGKIVGQSIETVKSNGMPEEVSLELTDEIIMAQIIVFFAAGFETSSSSTSYTLHELAYNPEEQRKVQEEIDRVLAKYNNKLCYDAVSEMTYLHCAFKEGIRMFPSLGHLVRKCTRKYTFPEMDLTIDEGVLILIPVQALHMDPLYFEEPEKFKPSRFLTDFINPMTKNIYLPFGEGPRACIGERLGLMQSLAGLAAVLSRYSVEPAPQTLRHPRVDPTSNIVQSVIGGLPLMFKLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG25</accession>
    <name>A0A0N0PG25_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="LADJ01052439">
        <property type="protein sequence ID" value="KPJ21532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG25"/>
    <dbReference type="STRING" id="76193.A0A0N0PG25"/>
    <dbReference type="KEGG" id="pmac:106707247"/>
    <dbReference type="InParanoid" id="A0A0N0PG25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ21532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="152" mass="16641" checksum="30B0B7951F42033A" modified="2015-12-09" version="1">MPAFVKKATERIPSFKGIKFTSNDLSEGAQVLRALKNGQEMFLGADTLIAPAALLGIKSSIGTTWNLFPRLAQDILDAVERNDIAKARSLQEKLSLAIEAHTVEGPWVPIMKAGMEIVSGIKVGPPSLPQKPISEEARKRIESRLRKLEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG55</accession>
    <name>A0A0N0PG55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase EHMT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01062109">
        <property type="protein sequence ID" value="KPJ21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG55"/>
    <dbReference type="STRING" id="76193.A0A0N0PG55"/>
    <dbReference type="InParanoid" id="A0A0N0PG55"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="3">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="17840" checksum="631D4236DF71B2C4" modified="2015-12-09" version="1">MSLGCRCEGSECVSGECACAALGVRAWYRAGRLPRTFPYHDPPMLFECNQTCACNARTCGNRVISRLQQLGSLGARVAVVRTSRCGWALRALQPLLSGAPAALYCGELLPHTAADARAHDHYMFALDLKQDLLDDGGGGGERGGEVAEQLCVDAAQFGSDSVAPPALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7J4</accession>
    <name>A0A0N1I7J4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ionotropic receptor 75a N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460557">
        <property type="protein sequence ID" value="KPJ13966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7J4"/>
    <dbReference type="STRING" id="76193.A0A0N1I7J4"/>
    <dbReference type="InParanoid" id="A0A0N1I7J4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF32">
        <property type="entry name" value="IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="678" mass="76867" checksum="AD43D396EBE85583" modified="2015-12-09" version="1">MPATPNTNMEIQMLPLLYLLVKLEVVVTSPSLIADLSLAYFQSRDVRHLCYLSCNTYAVTAHYVVETKNIVGNFIDQGIRTSVIMIDEETKRLEPAITQSNIPLGIYLDASCTKAKSLLTKASRNNLFDALHIWLIINYAENKTDERELDARHFFLKLNLSVNTDIVLADFRGDYYELIDIFNYGKIQGNGLEWRHYGTWSPKYGINTFSNNYKYKDRWNFHNLTLRAVSVILERPKVFRPAMLTERGYTPGVSAMTKVVAQLLHVLIQQHNFRFNYTIVGRWIGSTERNSTLAVTNSLFWGEQDISCTCARIFPKWLNWVDVFFPATTTLETKFYYLIPDKGVGDYENRFLTPMSPGVWWCACAAGALCVAVLAAAACLETRPEPHVYAFFSVFATTCQQEYEDGVQILQESFSSQGRRLILLVVGLTSMLLYNYYTSSVVSWLLNAAAPTLHDLDTLMNSDLELIFEDIGYTRGWLDNPGFFYYSGYKNPKEDELRNKKVINAKRTVPLLQPVNTGIELVRTGAYAYHTEPYTAYQTISKTFDDTELCKLGSLQMMQPAQVYIMAQKRSPYKEFFVWSLIRLQERGHVRAAQGRVSGPTPACSGSTPRALALGQAAPAFAVLAEATLLSVLILIIEILWHSNSSPAPSYSQLVLVCKLRYLRPAYARITMYWGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8U8</accession>
    <name>A0A0N1I8U8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460299">
        <property type="protein sequence ID" value="KPJ16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8U8"/>
    <dbReference type="InParanoid" id="A0A0N1I8U8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="571" mass="64242" checksum="7D1272ED9F385947" modified="2015-12-09" version="1">MLYAYAVSRELCGNYVGFSPLNGSIPTKPPLFLLRMVTGLREARRNEGAPSSWPFEAGDRFPRTCHHRAMEAGEAGFYSRLPSPWAGGAGINQYRPPWPHHTSGHEGCRGQDKPVRIRTPRGPTTLHLRWDPALGVLRGGTTLHGPPLAAPSWWAAIMRLLKALTLCLLIGLAVAAPRHHHNRERKESKESKESKESKESKESKESSESDQITITRDFFPDEFVVYTAKHDIVNILVPINSFNFEDDDEDNDTNDDDGVTVFFVEADIDKDGNRIDKGLYVLKDGKVKKLLDNGRDAAASSDDSKEVFFAAKDGIYAYNKNDSTAIKYGSVTDSIIGIAKENASDLIYILTENHDLYKVTELGDKKEKINEVVDAREIVLDNSNNLYYYGEDMKPFVLNSKGVKEIKGLPEHPKSVRLLKPPFILEDSVPFVIDNDLYFINANGTSEKSDFDFKSNAKPTAYSMEAALIQYYGYNKKIYEYNILALIFSEVIDELKEFLETKSDAIRSMSTQSRGRLRPNNSKAKSADGSGDDDDTRLTLAYENLYEVPRTIVERFSDHIKYLDISHNKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAT6</accession>
    <name>A0A0N1IAT6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460280">
        <property type="protein sequence ID" value="KPJ16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAT6"/>
    <dbReference type="InParanoid" id="A0A0N1IAT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="409" mass="46461" checksum="2EA924C3903DF067" modified="2015-12-09" version="1">MKDSQPKPTRFQLFLQRILGIRREKSNNGLPSPHMYAASDNNITNRYEKRRRRGMRFRRLRGAKKVYSESALRERQSPVILSYVQSVQRNCLMDTTPRQCPFMGCRMIFYGIINYNDHINLCHFTDRKFSCHYCHEGFLKERDKLLHENEHIGISKLSTNLTSTISGLHSKVANVTQTDPEPKQINEEKLKKIVSFFDKIEDPEEIIAELKKSRHSTSSVNLTHHSSKVDTVASGACKSTSNSRRSSCVHLQKADRKSSSSVESDTSSVHTSGSSLRCQICGQKFDDIQHLNMHVNAEHRSGSRCSGQGRSERPPSPPHYHDNSEDEEPPSVLANKSYSTLHHVNTSSTLTRFTSEEKSAMSYDPSTNIIYYSSSESVKNPSVMGETVKRVRAGFNSYKWEPGTDSIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB08</accession>
    <name>A0A0N1IB08_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB08"/>
    <dbReference type="InParanoid" id="A0A0N1IB08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="223" mass="24897" checksum="829A13778C17A927" modified="2015-12-09" version="1">MGIDNKSYVKSEDVEMNNKGHVSKSADKFSYEEALDLTGHGRYNYGLLFACFMIIIAMGIDIFGLGIIATAATCDLQMTIKEIGILSSMPFAGYEILRSTSDQTWRPITFYDPLSVCADILKSSAAESATYALLGECCNSRSRARYMLLMTSALMLTPTLYYIWGYFITKLDFSIPLLGIVYRPWRLLTLVMALPLGIGALLLYFFSESPKFLANVGRSQETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICZ8</accession>
    <name>A0A0N1ICZ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myotubularin-related protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ07000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICZ8"/>
    <dbReference type="STRING" id="76193.A0A0N1ICZ8"/>
    <dbReference type="InParanoid" id="A0A0N1ICZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF16">
        <property type="entry name" value="C-MYC PROMOTER-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="736" mass="81451" checksum="595EA156FE83E613" modified="2015-12-09" version="1">MYAPKCLVIVSRQDYIDTFRNCLGIIYTVWVENLGVPLETLVGNLVGCVLVPGAGGPQVRFSIGAGDRQALQPPAAPPMPVTHTAVHMLLRLLGIHNSVTLWCAVMSEHKVLLVSLAAARLSAACRALAALMFPFRYAHVYIPLLPAGLAEVLATPTPFLIGVHSSLKEEVSELLDVIVADLDVGSLHIPAGVNIPRPEGKLLGSLQEALALVLQPELRSADSAFAPPPPAASPPHMLDKEIRAVFMRTLAKLLQGYRHCLTIIRIHPSPVLTFHKAGFLGSRGLASCPFAVRLLDSMFFNGLVAERGPPWRPTDIFDELVQNLPEQLRLESLNPDTELQHIQDLAMQLHLNENPNPQVVSQTYQQRVLRPPAGAEARIHQPPLPALDPHRVHDVIRDVSQRNANNAKLTALRPPQARIVPPAAPPTGGEEPGQLLLTNSARRLEVLRACVAAIFEGRYADARKSFPAVLRALRASAARSALVRDLAARLPTNKHLLQHHQFELLVRLMNCALQSATALDEHSIAAAMLPLATAYCRKLCTGVIQYAYMCIQMNKVEMHEQLISDDRRRCMYERLMNCALQSATALDEHSIAAAMLPLATAYCRKLCTGVIQYAYMCIQEHQVWTSQQFWEAAFYQDVQRDIKALYLPSPTHHQRVPSPRDDEEYISLLKAQEPSALEIAAEQMRLWPTLSPEKQRELIASEESTLYSQAIHYANRMVYLLLPLEGAGRRADTRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDS4</accession>
    <name>A0A0N1IDS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01006721">
        <property type="protein sequence ID" value="KPJ20906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDS4"/>
    <dbReference type="InParanoid" id="A0A0N1IDS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8154" checksum="939A694733C51A6F" modified="2015-12-09" version="1">MGRRITRHRITALQAECYRGRAPTSRPTATTLVGRATHHAQGLPSPFAALKRAVTQLGFAALSCTDPQVGPHPNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE46</accession>
    <name>A0A0N1IE46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative maleylacetoacetate isomerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE46"/>
    <dbReference type="FunCoup" id="A0A0N1IE46">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IE46"/>
    <dbReference type="KEGG" id="pmac:106716148"/>
    <dbReference type="InParanoid" id="A0A0N1IE46"/>
    <dbReference type="OMA" id="CCQRIII"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000041">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ10080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="220" mass="25315" checksum="DE82004722232935" modified="2015-12-09" version="1">MSKQEITQKPVLYSYWRSSCSWRVRIALNLKEIPYDIKAVSLIKGGGEQHCNEYREVNPMEQVPSLSIDGHTIIESLSIMHYLEETRPQRPLMPQDCYKRAKVREICEVISSGIQPLQNLIVLIHVGEEKKKEWAQHWIMRGFRAVEKLLSSSAGKYCVGDEITLADCCLVPQVFNARRFHVDLRPFPIILRIDRELENHPAFRAAHPSAQPDCPPEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEU5</accession>
    <name>A0A0N1IEU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEU5"/>
    <dbReference type="InParanoid" id="A0A0N1IEU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="117" mass="13308" checksum="F32359F8355493A2" modified="2015-12-09" version="1">MYTKSDALKDARDLTKNLVGGDYERQYKEEKNGKGRRRCVLFGVSIGVLAVWLVALTLVREIQVRRLRSEVDQLTANVIALSANVMSLNQKLSNNRLFNEFKNLEDTVSLLTYLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFU2</accession>
    <name>A0A0N1IFU2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460144">
        <property type="protein sequence ID" value="KPJ17453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IFU2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19381" checksum="2311C0807A3B4CCF" modified="2015-12-09" version="1">MSFEDLRGEDPDATCTPGTWFNTENEKNCNECFCLDGTASFCYPYLCYGQKHKSIETCTPGHEFIQGVPSRCEGCKCKDNGRWTCWHEYKSCSANDCEVGKLWIEDDACSVCYCLSTGQKMCGSGEYCSKNKLKQKSLCTNQKCAAECYNEDKRTLGLCLEGDCVCTPANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH21</accession>
    <name>A0A0N1IH21_PAPMA</name>
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        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">RR48_05218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IH21"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="39329" checksum="8DA4013D2A314B84" modified="2015-12-09" version="1">MVKGRHGKYLLMFNGYTYYQHKTLRDGYRWSCTQMGSRSCRAFLHVTKEKLVIRAHTDHTHPPSTYSFESIKPRDHDERKNCTKRKLDVSFKIENIQGHHLKARSNAHRWSCTAYGSKWKCKAHLIITDKLEVLKANLIHSHPPRNKKSFHKPIFTMRKGEMDKDGNAPVPVIGDMHTVASLHDYFMAHSKLIKKINGKEVYLLNGYTYYMQKYLRRCAAYRWVCTTCNAYIHLDDELNILQMPSKEHEHIPKRDLIALANGRKLIMFNKYTYYNIGLLKGSFRWNCTVKSCQSYLMVSSNLDIEKAVEKHNHVPPKYKVMVKKSADTNCLSKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II60</accession>
    <name>A0A0N1II60_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_00980</name>
        <name evidence="16" type="ORF">RR48_10402</name>
        <name evidence="17" type="ORF">RR48_10406</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LADJ01043534">
        <property type="protein sequence ID" value="KPJ21395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II60"/>
    <dbReference type="SMR" id="A0A0N1II60"/>
    <dbReference type="FunCoup" id="A0A0N1II60">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1II60"/>
    <dbReference type="KEGG" id="pmac:106707667"/>
    <dbReference type="KEGG" id="pmac:106713190"/>
    <dbReference type="KEGG" id="pmac:106713222"/>
    <dbReference type="OrthoDB" id="7430073at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ21395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13795" checksum="CA26256CED3EECA8" modified="2015-12-09" version="1">MPPKTSGKAAKKSGKAQKNISKSDKKKKKHKRKESYAIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREVQTSVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJR3</accession>
    <name>A0A0N1IJR3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calreticulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035438">
        <property type="protein sequence ID" value="KPJ21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJR3"/>
    <dbReference type="STRING" id="76193.A0A0N1IJR3"/>
    <dbReference type="InParanoid" id="A0A0N1IJR3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="13648" checksum="3A2E6B86E5A87EC4" modified="2015-12-09" version="1" fragment="single">IDNPAYKGPWVHPEIDNPEYTPDSKLYKRDELCAVGLDLWQVKSGTIFDNFLITDDLEVAKERGEALKKTLEGEKKMKNEQDEAEREKEKAEKPDDEEDDEDLDEEAGEAAPVDEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJV0</accession>
    <name>A0A0N1IJV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein O-mannosyl-transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047478">
        <property type="protein sequence ID" value="KPJ21447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJV0"/>
    <dbReference type="STRING" id="76193.A0A0N1IJV0"/>
    <dbReference type="InParanoid" id="A0A0N1IJV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MIR" evidence="2">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="117" mass="13438" checksum="453CB42236283558" modified="2015-12-09" version="1" fragment="single">ITTYTHKDDNNRWVVKPYDRESVSGDGIGDANDVWKILISGGKDGEEVQTVRSKLMFVHYLQTCVLTTTGKQLPKWGYEQQEVACNPNLRDKHALWNVEDNLFDDCKYVITTFNDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ING6</accession>
    <name>A0A0N1ING6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-lysine N-methyltransferase NSD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ING6"/>
    <dbReference type="STRING" id="76193.A0A0N1ING6"/>
    <dbReference type="InParanoid" id="A0A0N1ING6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="24030" checksum="2D2E52B715AE0D33" modified="2015-12-09" version="1">MPQARRKTPFSGKAKKQQLQAKKNKNLLLSSSTSSNAYDVVSVNYQPKARGRSDANRYALKFSLLIIIEVTFNYNLQCAGIEKKQCLCGAKRCSGYIGAKPKQNEQPKKKKDVTKRTYKKRKVEYSPTVRPKPVKRQTSRSNPKELTEIEKDLLIIKLATSGMSSDSDCSGRLSVDSAKERRTMKRNRDKISCDDLYNDFSSSNKRFKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP80</accession>
    <name>A0A0N1IP80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460544">
        <property type="protein sequence ID" value="KPJ14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP80"/>
    <dbReference type="STRING" id="76193.A0A0N1IP80"/>
    <dbReference type="InParanoid" id="A0A0N1IP80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF18">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="512"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="687" mass="77909" checksum="4660E1C9DF821AB3" modified="2015-12-09" version="1">MVGGERVDLQKGFVPSRIENEGSNVSKKLEKNKNLRINSTKLAINERYRRLIPYMTFYYANDLVAPTTEAYNKNNVEVEKAQIVEAGTLQPQMQHGPKVVYSTNRHHNIPRYQGNRLTHFNIASANPTKIFYSKDGYPIVVQNVPKLTSHYNPSILDHHVAEHDPRRYVAKEPKFSNVQYTSARKPYINVHHSEENAQYYFPERDDIKYKLVPYDQTPPIKNLPQIEYDNAPKKFYNIPSEDLNDSVYIKPRPRPQYHFDELKTEHGKNRKPPATISEVYYEKQNPLPISEPVIETGFKPIISQTTESANPLLYTQTLSATDLNHYDVEKPQELQIESGPEALEDNDKSQYEQYVVKQPTFKPQPETANAITLADLLNSLQLNKSIPKPITKENVGSSIRILLQALNDLKGKLQQSEVDPPVLSSPTPFVAPKPSVTTVKPVIQTTSSPAIEDTGLSEEAYLAEVENPSQHLDDYTSTSQRFPLPITSDEEGGTPGHPGIDYPILTVIPQTKFDCKTQRYKGFFADPETRCQVWHYCDLNGGQASFLCPNGTIFSQAALTCDWWFNVKCSSTAQLYVLNESLYKYILPHSPKFPEDYSGPLVDKYLTLKFKEMEEEFKKNKNKNKQGAEDKIDSNEDEDSKEDEKDVSASSDEKEDEIAKKQSNTVSESSVIVATSGASGNVQRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPC3</accession>
    <name>A0A0N1IPC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPC3"/>
    <dbReference type="STRING" id="76193.A0A0N1IPC3"/>
    <dbReference type="InParanoid" id="A0A0N1IPC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000092">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000007">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="269"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="359"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="462"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="571"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="650"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="757" mass="81791" checksum="C093F73AFA7E9B7C" modified="2015-12-09" version="1">MAFMSGLWNSIVGGNEKEVNWNEFATLYLDSRLKYFSVSEIDKEASPIVYAEAHKITFNKTGLGLNYTPLNFVTIFHIDTRKEDNRDGTVSIKYDPREEGVHELYVKYNGEHVQGSPYKFHVDSISSGYVTAYGPGLVSGVSGEPSLFTISTKGAGSGGLSMAVEGPSKAEITCHDNKDGTVSVSYLPTAPGEYKVSVRFGDKHIKGSPFTAKVTGEGRKRNQISVGSCSEVTLPGKISDNDIRSLNASIQKMGVHIQNSPFNITVLDQEVGDAKKVKVSGTALKEGKTHSENTFTVDTRNAGYGGLSLSIEGPSKAEIQCADSKDGVLAISYKPTEPGYYIVNLKFADHHVEGSPFTVKVTGEGSNRQREKIQRQRDPAPLTEVGTNCKLTFKMPGITSFDLAATVTSPGGVSEDAEIQEVEDGLYSVHFVPKELGVHTVSVKYREIHIPGSPFQFTVGPLRDSGAHLVKAGGGGLERGEAGRFNEFNVWTREAGAGQLAISLEGPSKAEIDFKDRKDGSCDVSYKVDEPGEYRIGLKFNEQHIPDSPFKVYISPAVGDAHLLEVAQFPDSAQVDKPTQFYIRLNGAKGSLDGRVVSPSGKTDDCFIQNIDGDQYSIRFMPRENGVHNINVKFNGVHIPASPLRIKVGKDDADPAAVHAHGPGLGTVKTGAKTDLIIDTCNAGAGILAVTMDGPSRVAMDCTDVDEGYKVRYTPLSPGFYYMSIKYNGHHIVGSPFKVEAIAHYTSPLRGSEPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPJ4</accession>
    <name>A0A0N1IPJ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460301">
        <property type="protein sequence ID" value="KPJ16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPJ4"/>
    <dbReference type="InParanoid" id="A0A0N1IPJ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874095" evidence="1">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14171" checksum="19E045C802BB7575" modified="2015-12-09" version="1">MAAVRSLRTSGVFLLLFLLNIANASSGPWIFSVDVNEKACSELKCVYNLNVNGLDFDVWSLTEVPAARGGDCEGRFLEEKSTKNVELIVPFAKKLFFCAKGPDGVWYNQGESLFLEANDVIGANAQYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPR2</accession>
    <name>A0A0N1IPR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPR2"/>
    <dbReference type="InParanoid" id="A0A0N1IPR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="12033" checksum="7C308840FE71C0A8" modified="2015-12-09" version="1">MADSDTLERYQQWKHSGTSRITTSRARHLTRLRWSAARMRLSAAERDVRRVGRPRANGLSYHLSTNWRESERLHVTCRKEKGSQHLVPLYRRDCAVTDSGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPT1</accession>
    <name>A0A0N1IPT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPT1"/>
    <dbReference type="STRING" id="76193.A0A0N1IPT1"/>
    <dbReference type="InParanoid" id="A0A0N1IPT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="450"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="602" mass="67235" checksum="980A4A32AB714610" modified="2015-12-09" version="1">MAKKHTAEQRPYLFCIATLMRAMTPLRLLHVVHVLTVARLVSPEHYGRSTHVNDAECFDFVVVGGGTAGCVLANRLTEDEQTTVLLVEAGGDPPYESMFPGLFPAMAGSRVDKNYTSENDGRTQQCHRNRVANLTSGHMLGGSSGLNYMLYVRGGPSDYAHWAAAAADPTWAWPDVLPYFIKSERLEDPGLLNSPYKIYHGTNGYMGVAREHRSEINKFSEAVREMGHEVLLDVNGYRHLGFTNPLFNIADGVRQSAAYSFLAPIVHRKNLYILKNTLVTEVIFDEKNNAEGVKVKTQNGTILSLVARKEVVLSAGAFKSPQLLMLAGIGPRDHLEDLGIPVRSNLPVGLNYQDHVAVFMSIKMEESNAPSAPSNKHLFPLPTFVGYVALDKRQEHPDYQVVNFVVPHDSEFPFNLCAFGYWFDFDICHNLRNGGKGKTTLFSTLNILHPRSRGRVTLRSRDPEDPPVIHTGMFSDERDLDDLARYLEDHARIVNTTYFKSVGAEIVDLKLSMCRGLRAGSGQYWRCYARCMMNTMYHYAGTCALGGVLDSRLRVRGVRRLRVVDASVMPTLPGGNTHAPVLMIAEKAADFIKEEHRLFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFU5</accession>
    <name>A0A0N1PFU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461033">
        <property type="protein sequence ID" value="KPJ09971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFU5"/>
    <dbReference type="KEGG" id="pmac:106716273"/>
    <dbReference type="InParanoid" id="A0A0N1PFU5"/>
    <dbReference type="OMA" id="FWKNRAF"/>
    <dbReference type="OrthoDB" id="7398390at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="28921" checksum="6D6CC614527B3200" modified="2015-12-09" version="1">MSGLFDVDDILSDHEEWLKLDEEWGKPIDLDTEEDQAPYLKSMFSTLDLKKTTFDSSFLFKKVRRKIGRQLSKRSTNSYLDYKDFLNDLQNNASRESTKQFYFVNGQIMSAVSVEEICDKIDNYFKSIEKLTLTSTIRNKNEMPEVVKCSMSSGDFSFDDTVVGSNTDKCDSEDISRFIDQAFNDFNSSIASMEDVDDVTRESVTTLVRKFSSVLKSPSMNCCPRRQRQCCEKFRDLAEFWKKRTLEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG47</accession>
    <name>A0A0N1PG47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein pygopus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG47"/>
    <dbReference type="STRING" id="76193.A0A0N1PG47"/>
    <dbReference type="InParanoid" id="A0A0N1PG47"/>
    <dbReference type="OrthoDB" id="270215at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15637">
        <property type="entry name" value="PHD_dPYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="48981" checksum="AFFF9842BC3584B9" modified="2015-12-09" version="1">MSHNLAGMPSYRMSGPGLGPSDFKPPMDTPTPPAPAPSNPKKRRKTSNANNALTPQPPPTAQDLLPPPLTGYGDTIVASNPFDDSPSTVSHNGPMMSQNGPMMSQNGPMGMMGPMHNMGGPPMRHMSPLPHNMSPMNQQMPPRGGISPMGNMSPMGHMGGMSPMGGPNMGMSNHSMGPGLGPSRSMGSPMSPMNSMPMGSPMSSGPMGSPMNMGSMAGSHMGNSPMGPPMHSPLGAGSMNGPMGGGGPGMNVSRMNGPMGPNCSNGSMGPTSSIMSPSPMQSGGMGPTHCGPMRHGSPMGSGMGGGPMGNNGPMTSMGPGPPYNSSHMGHGGPMSMGNSGSMGMGPGPGNMGNCGPLGGMSGMSMGGPGGQGPMGQNMGMFGPKPMPVSAGKVYPPDQPMVFNPQNPNAPPIYPCGVCHKEVHDNDQAILCESGCNFWFHRGCTGLTEPAFQLLTAEVYAEWVCDKCLHSKNIPLVKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHA2</accession>
    <name>A0A0N1PHA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHA2"/>
    <dbReference type="InParanoid" id="A0A0N1PHA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="10818" checksum="27CDDB2E1BA0194B" modified="2015-12-09" version="1">MATLSLSYNHIVSVGVRRAACSVRRAACSVRRAACGVRRAACSVRRAACGVRLLAAEWARRVGARRVQTPRRQLHAPPVRRTPRNRRFCRTPNTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIK9</accession>
    <name>A0A0N1PIK9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasomal ATPase-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIK9"/>
    <dbReference type="STRING" id="76193.A0A0N1PIK9"/>
    <dbReference type="KEGG" id="pmac:106709281"/>
    <dbReference type="InParanoid" id="A0A0N1PIK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="43003" checksum="C17620DDD61FCED2" modified="2015-12-09" version="1">MPSTLPVVTIQCDWIDVLRLVKGEFWISSKYRDQNSIHDKIKALVNQADGKLQIKCPDTYQYLSHSNLSLVLKHLSSGLKVAFVAPTKTHIVHKKALLSISSGENALAVSSCEEDKLLVWDTRTDEILLDLKGHGGPVYKCRLFPSNVVLISAGADGSCRIWSAESGINPVTLIGHKMSISDLAIIDKGRNVLSVSKDGTAKLWDVGESRCIDNILEGHGPINCCAIANSVDEVTIDNDREVGTGNKLLVAGCESGLIICAHVGKRTELYKQQLDSSVNACIIIDQVIIAGCSDGKIVFINVQDGSIIRDLHESNNPVLSLATLANNMFVVGRQDGTCTVFSMNDSHIAIRVQLTGSDCDGIRDIAFNGKWILTACRDGKIRKYDYNQITVHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJC8</accession>
    <name>A0A0N1PJC8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460328">
        <property type="protein sequence ID" value="KPJ15658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJC8"/>
    <dbReference type="FunCoup" id="A0A0N1PJC8">
        <property type="interactions" value="1488"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJC8"/>
    <dbReference type="KEGG" id="pmac:106710141"/>
    <dbReference type="InParanoid" id="A0A0N1PJC8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="256" mass="28011" checksum="99B9CDAD6DC12CEF" modified="2015-12-09" version="1">MTTLKQVPLTCGGHTRPVVHLDFSDVTSDGFYLISACKDGKPMLRQGETGDWIGTFEGHKGAVWGVALTQNANLAASGAADFTAKLWDARYGEVVHTFDHEHIVKSVNFNADDTLLLTASNEKLIRVFDLNKPEAGGTNVSFYSSDTMRKMREFSVPTACYSASLAPGRATFVCGGEDLKVYKFDYNTGTELESNKGHFGPVHIVRWSPDGELYATGSEDGTVRLWQGVPGRVYGLWRRSHEPAPLANGYKELAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKN6</accession>
    <name>A0A194QKN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKN6"/>
    <dbReference type="STRING" id="76193.A0A194QKN6"/>
    <dbReference type="InParanoid" id="A0A194QKN6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ05959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="47" mass="5015" checksum="20BB4C139BB560E8" modified="2016-10-05" version="1">MALQAAVKGKLISVIGDEDTCVGFLLGGIGEINKNRHPNFMVVDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL09</accession>
    <name>A0A194QL09_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL09"/>
    <dbReference type="InParanoid" id="A0A194QL09"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9243" checksum="7977B6A0958862D3" modified="2016-10-05" version="1">MSEQELSRDGPTDNGIPPPAPLSTSSDNASVSTTASTIPRAAEHARPTTLPKPSGLKLPSKIGRLCSNAAPKPAVPISPRAAMIIEMTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLM3</accession>
    <name>A0A194QLM3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLM3"/>
    <dbReference type="FunCoup" id="A0A194QLM3">
        <property type="interactions" value="1903"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLM3"/>
    <dbReference type="KEGG" id="pmac:106719880"/>
    <dbReference type="InParanoid" id="A0A194QLM3"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="172" mass="19060" checksum="98B75A83CAD51C81" modified="2016-10-05" version="1">MSLTKSNKKFKWALDFNPKSRTSASDLPSPPGYSQSTNANYTESSKDTDSNLLLIKKLWDVALGPLKQVPMNLFIMYMAGNSISIFPIMMVGMLIVRPIKALFATQSTFKMVEGTQAVGQKFVYFIGNVVNILLALYKCQSMGLLPTHSSDWLAFEEPLTRVEHIGGGISML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLS0</accession>
    <name>A0A194QLS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLS0"/>
    <dbReference type="InParanoid" id="A0A194QLS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7225" checksum="096B7C231F544A62" modified="2016-10-05" version="1">MPKNILAEMGSQVGLTPAVQNRKKKVNELFADGLSAAARRRLWNNLSNLPATEFPTLFTEVQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM90</accession>
    <name>A0A194QM90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear hormone receptor FTZ-F1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM90"/>
    <dbReference type="STRING" id="76193.A0A194QM90"/>
    <dbReference type="InParanoid" id="A0A194QM90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000036">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF25">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="31597" checksum="7E4676DBC4F0B320" modified="2016-10-05" version="1">MRHASSLNIVNGPGSYSSRGEASNSRLTPEIPTLLQEIMDVEHLWQYNESELSRLGKSGSGAGAGSGAGAGANPLLAASGITPHTSSADLLADLCHIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLVLSCCYRGVGTPGEVRVGGGRGLTLHQSAKFGLTPCIERMLSFTDHLRRLRVDRYEYVALKVIVLLTSDAPELREAEKVRASQEKALAALQAYTAAHSPDAPAKFGELLLRIPELQRTCQFFMQVGKEMLNPANKSKDGDGPSFNLLMELLRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN77</accession>
    <name>A0A194QN77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN77"/>
    <dbReference type="FunCoup" id="A0A194QN77">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QN77"/>
    <dbReference type="InParanoid" id="A0A194QN77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="27150" checksum="967255E917B84AE5" modified="2016-10-05" version="1">MLASGTLTTELYHRTGLLAALWRATADLTMAVHVAHTYSNGQTISFNKMPLQLTKPAPQFKTTAVVNGEFKDISLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSERADDFRKINCEVVAASTDSHFTHLAWINTSRKQGGLGPMNIPILSDKSHSISRDYGVLNEETGVPFRGLFIIDDKQNLRQITVNDLPVGRSVDETLRLVQAFQYTDKYGEVCPANWQPGAKTIKPDTKAAQEYFVDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNS6</accession>
    <name>A0A194QNS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCCH domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
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            <begin position="222"/>
            <end position="252"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="424" mass="49458" checksum="4D8EC466206F7602" modified="2016-10-05" version="1">MHVNPYFSQVDSRSNYDQSLNPTKRRIFVNPNFIRPNNFVNNSKSYAPSLYYETPLLKQNDIENSSTNFNEHIVSYQNIHENLETKLSPAVTKSRYTLVRKNDKCTANVETIRTTSTVKISKYKTMQLSLIKNNIEQQPKKPEVKLQTTQYRNQSLSKYNYITKSTYQSSSVNRTYIKINKQTPTVRKSIEVKTSIKIPKAKKTLFSPNVSINRKTIARKYKKNNIPCPLFTKYGKCLRNIQGNCEFLHDKKHVSICRKFLKGICHDPACLLSHELSAKKMPTCYFYLNGNCTKINCPYLHVKLNNKTKLCNDFLKGYCENGDRCIYRHVNKEVKTAIKQNMNRQRRFTCSTPIVMPKKIKIKPVLKKPAERYKSVSETERDQDEDVNCRYFKNDTQEDEQNQTCDVIKPSRCKLGTLPSFIKL</sequence>
</entry>
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    <name>A0A194QNV0_PAPMA</name>
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            <taxon>Endopterygota</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="46"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="102"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="29293" checksum="085B929317E35CEE" modified="2016-10-05" version="1">MRRSSPVQQWLDSLPADTEVEEKLVEDQAENTQSDENKAENSVTDNTVVELSNVELKDDKNLDVPTQKEIWKRKSLESGMLTSTPNNRSVKKKLQRDHSVQSEGCVPRFKNPLLRDHSLQSDASGSSSSSVLNVLGARKVDAESVLLALGFGPSEKQQKLQRIPDRFLVPSKLKGISTEKFIKDEQLSMRMHDCGIFGYRGLTGNPHVPPSTIVAKIMECILHDNVCREEALMKARHSIADLRGAPALHAQLARAAFNRQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPP0</accession>
    <name>A0A194QPP0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11444</name>
    </gene>
    <organism evidence="10 11">
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
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            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016094"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="422" mass="47991" checksum="C0F726ABB99C1376" modified="2016-10-05" version="1">MQNLDSDSEDELPPGWVEKSTDDGNVYFVNSCTNKIQWTHPRTGRKKVIPEDLPFGWTKTVDETGKTLYIQQETGNKTYVDPRLAFATEEKKHVNDFRQRFDSSTTAFQVLHGIDLSGKFALITGCNAGIGYETAKSLARHGCNILMANRNMEATKKAMSDIVKETNASEDNLKSIHLDLASLESVKKCAMTVKTIFSDYLDILILNAAVFGLPYTETVDKLETTFQVNYLAHLYFTLLLEPLLKKGTRVIFVSSESHRFASLKNVFNQQNVAMTRDSYSSMMAYNNSKLYMVMVAKILSEEWRDKQICVNSLHPGNMVYSNLSKSWWLFRLLFFIVRPFTKSMQQAAATTVYTAVASELENVTGLYFNNCFYCAPSELSRDEDLAWEVFTLSLKIIEERMGSDGIQKYLDKCITRLNGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQE6</accession>
    <name>A0A194QQE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sodium-coupled neutral amino acid transporter 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQE6"/>
    <dbReference type="STRING" id="76193.A0A194QQE6"/>
    <dbReference type="KEGG" id="pmac:106718727"/>
    <dbReference type="InParanoid" id="A0A194QQE6"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="43"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="518" mass="56738" checksum="12E1F4CE0D256174" modified="2016-10-05" version="1">MKIMRLFDSMRGSSAVGVRPTIHQGQYTAGETTGGLSVLFTMLCIVDLFGVFPVVALPKSVIACGLYGIPLVIAVFSLQLYTAVLLGKSWLLAYELSPNIREKSRFPYAAVAELAFGDNARRLVTFFIDATVFGAAVPNFIFASQSMQLFWWKISGGSVGVTYCVWMVVIGLLLCPIMWLGSPKDMKSLALISVCIVGTVAVATWYCILTDDESPSSLGGVLDYTPEIGDFLTAYGIIAFQFDIHPMLLTLQVDMKDSRRINAAVLAAFLTTGLVFLITTLLAANRYGDSVESNILQGIPPSITLYIVALLVTLQLCLSSAVGNSALFQHLEDLLKIPRNFCIQRCLMRSSIVALAVFLGESVPRFDLVMGLVGSTLTGPLMFIFPPLFFLKLCYLKSINIKQEFSMSYKPKVSVPERNASLQDGVDLSKLPLVSNESLSNKYQTFGSYEEIYRAYIDEYNVKWYDVLLAFLVMLLGMTATVVATYSSWSDAISSATFSPPCLLNATAAARSFIQDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRI8</accession>
    <name>A0A194QRI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRI8"/>
    <dbReference type="InParanoid" id="A0A194QRI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="58" mass="6423" checksum="5704C6B8AB8B02B6" modified="2016-10-05" version="1">MHLPTPLRTPSTCTSLIGTPVHNAHYPPSRALRERAVQQQRAARDRQPRRAPLAAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS14</accession>
    <name>A0A194QS14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS14"/>
    <dbReference type="InParanoid" id="A0A194QS14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="751" mass="84851" checksum="FA92C549BA0966E0" modified="2016-10-05" version="1">MGEHIGTKDGEQYPLLKVDSGGNDGSIRVPPPPPCIITSGCHTTRTPKQSWMDRWPEFVSACWITFILIAISFLAFYTLGINAYRRQPLIINKCNASKLASTVTYHHIVPRGSYVSFLVYSDYISSIAQQYPSLHINVFFLMDDSSQTPIQGSRHTRLYNKLIQSTNNILDIFDQNNKKEIMIIQKKYPNVNVTTMFLSKYMASTPHRYKWRTIPIYFLNFYVRVFTVWQYGGISMDLTTYNDIYIMRRHLDRRISAILRQHNDGIESEKYVNALKRINEEEQNEFFAMFNLLIHHVLNETCSFFNRSLWYNSEAVPGLSVNKHAIRSQRNKRDSRVTYEGESDLNNLALGVTPTVKSSTTDFKENGTYASASSSMNDTATSTNATTNEVRNKTFTSENSTTFDNITKHSVAELDKVVNFTNTHDGLLPYIAFYDISILTDSIPNMPFPSEFINPPKPINQFETYEIVTENLNIYDHQLTLPVLVISTDGTFVAAPTRRHPMLAYLLSFACERFINACHLRRHFGKNVENAQDSNVQSNTLIVHDLKIIAASMGIVQHTCLLVGCFTLNKENEEESAVGVRTKLRALMVALFGISMSLCAIASQPVELELDDDEVAQRLNNVTFARRIAKPTIRLVIGYGTLSATVTAVTSLLLLIAVMSKKSWWQRGARWLAAPALLVAALEAASDASDALLVTILRSSQAPIRLFLQSLAACALITTEILIWYFIAKFFEYNPSALDPAEEKKLKGKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSR7</accession>
    <name>A0A194QSR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease easter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSR7"/>
    <dbReference type="STRING" id="76193.A0A194QSR7"/>
    <dbReference type="InParanoid" id="A0A194QSR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="204"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="50979" checksum="0D88635B7E8C9878" modified="2016-10-05" version="1">MQRNDQQKWLNLFPCQSFDRDFYESTTDFICCSGEHAWSILHEPKYLDKNIKSDNLSYMRRKTFGYENNNGNNFNNMIQSVFLPNQRRPTVVNQYPCTNSACFNQPGSNNRGIIPPQFVQAPRPGRPDGRLGSVTRTLPQQCEASILPPNPNTGCCGVDTFGTNGITDAQTVVAAMSNLPLGNYRRFKRQSDNVKVEIELDNRIAGGTETELNQFPWTILLRASFDFGVNVTKFDCGGSIISSRYILTAAHCVVTDGATLTNVEIYMSEYDKRTFPMDCKTSADGQKSCITNVVVQAEKVVPHTGFNSKTLKNDIALIRLRKPAPYTEFIRPICLPPFDINSQAFFDLPLPVAGWGRNVQFESNIKQSTVLNLVPRNDCLKYYPYLQASHMCAMGKTGEDTCKGDSGGPLMMIYGGKYYVVGIVSGKRSDVPCGTAVPSLYTNVFVYSQWILSNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTB2</accession>
    <name>A0A194QTB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 307a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTB2"/>
    <dbReference type="FunCoup" id="A0A194QTB2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTB2"/>
    <dbReference type="InParanoid" id="A0A194QTB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="528" mass="60498" checksum="21608C56ABB4D969" modified="2016-10-05" version="1">MALVRRSSATKGGNSSLESAGSGQVLPPGVGAQNRRSVAGMSMELFEQHQGTHILQGIDIRLRRSFEYDRLPQLSFKIHCLQCTYRGFLRPKFPFKTYYYLCIVKANEMDDDMFYALALCDWSNLQLRRRNLARRHCGPKQHTDNFSRIGSVATFESIELLQTLKHITRNTESSINIKPLLMMSAMNMFSNYMCSVRFDSETDVEFKKIVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMEKLSNWSQDIRSFILSRIVDQREIHLDTEGPEKDFLDGLLRVLHDDPNVDRNTIIFMLEDFLGGHSSVGNLVMLCLAAVARDADVGKKIKAEIDGVTKGKRAVTLSDKINLPYTEATILECLRYASSPIVPHVATEPAVIAGYGIEKGTVVFINNYELNTSDKYWDEPEKFDPNRFLERNKIRVRRNSLCDSGMESDSERSTPINKTSDTEKEVVNVRKNIPHFLPFSIGKRTCIGQTLVTTMSFVMFANIIQEFDIRAENIEDLKQRPACVALPKETFNLYLLPRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUT1</accession>
    <name>A0A194QUT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuralized-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QUT1">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUT1"/>
    <dbReference type="InParanoid" id="A0A194QUT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="270"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="481"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="644"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="847"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1619" mass="178204" checksum="160DC1E92459FB0D" modified="2016-10-05" version="1">MRFHRRCGDRVTLLHNNYTAVRNFVEFNHGLVLSDQPLKNDVMFEVCIDRKVNVWNGSLEIGVTTQNPEYMDLPATATKLRNTAWFEVCIDRKVNVWNGSLEIGVTTQNPEYMDLPATATKLRNTAWILSGSSVVRDGVTHLPSYGPELDTLQEGDCVGVMRTSRAELLFFINGRCLGVAAMDMPPLLYGVIDLYGQCVQITLVPQSPTTPRSTITNAESQNEATRHDGPVALMEVVNYEPSVDTFPKGSRDEYVNNSTEASCTHYNQDRLRFHTRCGVLVRFSHHNRTAERARPMDDYNDAVVMTSRPLHDGELFEIRIERLVHKWSGSIEVGVTNHNPATLNFPSTMTNMETGTVMLSGSKVLINGQGTCTEYGSMNLDELKEGDMVGLMRKSCGSLHYFINGVDQGVAARDVAAPVWGVVDLYGMTSKKRLKHSRLYVRCRHRLVSSPTGALHQDELAPEIDMDADIDTDTNDIEDDSHLFHTMRASNVVIINNGKTAYRPNAMEFFNEGLVMTNRPLKNDELFQVRVDVIVPKSGTWALVGEDVIRDGVIISSQYTRNLNRLVEGDTIGLMRTSLGVLHFYINGEDQGPAAYNVPDQIYGIIDLYGRAGQVSIVEGRVDPPVYSPESPLSTESIITSFPEMCFHLVHGRNAVLSRSRLTASRAAVYSEFNDAVLFSSRPLRECDMFELRIDAMVDCWIGSIEMGVTGIRPEDLESGAGGALAGTATDLTGDTYVLSGAAVMKDGECVRSGYRLDLDTLSVGSRVGMMWHADRSLHYYLDGMDMGQAWHVPHLNIYAVVDLYGQCTQVTILQNEARTFNYNPGTASDNSLLDMTQQPAAPPQPYCTFSEYCGDNVRVTKEYSIATRFLPDPAGAIVFSSSHLAQDEMFEVKILKQRAGFAGGLRVGVTDVNILNAHVNRSLPPAIIYLPHFTAYIDGKHMFYSRPGSRERDARLVVPSFEWLRPGDRIGLKLTSDHRVVVYYNYEPLEVAFEGVPDKVYAVIELHGEVSKIQAMNKMTANALPPHLNESFMRREVETFQEVTSLKPCEDMDGSMEGIEGTPALSPAPAAPPAPTAPPAHRNPRPYTFHNVHGNNIKLCSSDTVAVRTTSYNGGLAVVSQPIRRGQSFMFRVDKVDPTWSGSVGVGALGYLPDELPDLAGAIDPPAWLLAPDLCADNGIYFRGEAGRALEEVSERSVVSVEFLCDGRLVAAADGRPLCALGLVPDTLDVLYPLVDVYGKVCQVSILLHPYVLGSGASLDLPSVTATREDSSGVSELPEDDVSPVDLDAGTSVAKPKLRAHSHSGLAEELAAATRRPRVGGPAATTMHHSLMLPPPARERMHKSHSSHSLGEARRHAYADDPFAERHLCDTNIRHNDRYPEASEVDNLDIEIVDALTLETGNLPDLTEDHSSSIDDSTRRDDLCTDTLSAENVHYLSALLGLERGGGECEPSEWERAVGGRDCAHLALVLDYWRCLLQPLPELRRGCAWGRAECHCSGCHPDLRPPLAGWVRIERADAAGGAARAYWPLSRAALAGVRSCCARARRPRRPTALTPSLARLPASLYDVWFDVQGTPHRVALALEIDVEGKTPESDCMLAVLIYMKPHSTLADSPCGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV36</accession>
    <name>A0A194QV36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV36"/>
    <dbReference type="InParanoid" id="A0A194QV36"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="9761" checksum="1BBC2B9CECEE0A2C" modified="2016-10-05" version="1">MGAREHHPQKSGNCDCAVTGTCVYVVRVTCCLPMRVTLRDAGAGTQKKLSDLRPKFVQATVSTVSDFTSHLSHRLDTNRTANLSATGASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVA9</accession>
    <name>A0A194QVA9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GORAB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVA9"/>
    <dbReference type="KEGG" id="pmac:106718930"/>
    <dbReference type="InParanoid" id="A0A194QVA9"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF2">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04949">
        <property type="entry name" value="Transcrip_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="329" mass="37626" checksum="01AF177C826E3288" modified="2016-10-05" version="1">MSTFTGFSEEDLKRIKSAESFKSSGSIDPDFDLSNVRKIEKIGAKPKKGIIKNISPILRKQDSDDAIDSIEFSKCKLSIKTPTTPSEHTLSNIDDKEEMIEDIKKNDTDGENEESNSLSGEEIENSLDRRDSIVTPDIVRGVENYSEDELAAHRVKLQELQLKQKLMEEQNKKRKEMLAKALADRTRQTEEEVLRLEKIKKELQVLDGQFSHDVALLRKKIDQACLSYSEAEKQYLKVEKEFLQAKINLQKEKEKKELLTEHLCALITHNETRKAQKLETLMLELATDKKIILSETEPNPEPTIEDKKPVIVDGIDERNGKMVEITNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVW3</accession>
    <name>A0A194QVW3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ejaculatory bulb-specific protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVW3"/>
    <dbReference type="STRING" id="76193.A0A194QVW3"/>
    <dbReference type="InParanoid" id="A0A194QVW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="146" mass="16816" checksum="38A80D98AF20AE24" modified="2016-10-05" version="1">MKHTVYSCFFTAFDTSKMVAKNLMILCCLVAAVIAKPTYTDKYDNIDLKEIKENKRLLVAYVDCVLDKGKCTPEGKALKDHLREAIETGCEKCTEKQKEGSYEMIEHLIEKEPEIWNELCAKFDPTGKWRKEYEEKAKAKGIKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY7</accession>
    <name>A0A194QVY7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVY7"/>
    <dbReference type="STRING" id="76193.A0A194QVY7"/>
    <dbReference type="InParanoid" id="A0A194QVY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="565" mass="65906" checksum="0B421E07AA44D7A8" modified="2016-10-05" version="1">MAECNRTNYRKSNHKSSRSDRKIESVMEHGKKTKVKHTDSRTPPLPIMEDFSMEELLKKRNLLCANLEKYKTYSFNETKILKNSNERKRKQINRDKRDNKSKNYNADTKSIKESSPEYNQEGIHSSESEDEEYIIEQRRKQRKQLLDHLNNSQNIINIEEDSNIQNTSQVDCEVENNDTANSIKSTVKEITDMFSEKDEFPKNKDPEVIIQDNNDKNAELADNWDDEEGYYKARVGDCINNNRYTVKSILGQGVFANVVRAQDHTFKGNEVAIKIIRNNELMQKTGLKEMAILKEINDNDPDDKYHCVKLLRNFIHKGHLCLVLEPFYMDMRSLLKKYGKHNGISLKALMIYTRQLFLALKLLSKIGVIHADIKPDNILVNENKNVLKLCDFGSAAKVNENEPTPYLVSRFYRAPEIILGIPYSYGIDIWSTACTVYEMATNNILFTGGSNNKMLKCFMDLKGKIPSKLLRRSKFKDQHFNYKNNFLLRKKDKVTEREKVVEMNHIVICRDLQRDLKQYFKKLTSSEEKKVVQLKDLLDKMLMLDDKQRLSVTDGLKHSFIQVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW07</accession>
    <name>A0A194QW07_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SRA stem-loop-interacting RNA-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW07"/>
    <dbReference type="FunCoup" id="A0A194QW07">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW07"/>
    <dbReference type="InParanoid" id="A0A194QW07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000494">
        <property type="entry name" value="28 kDa ribonucleoprotein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="9411" checksum="EB8C5A02406CD62E" modified="2016-10-05" version="1">MASTARAARLYVGNLPWTVSHRQLREYFAQFGPVQSARVVFDRSTGISKGYGFIEFSNTSAVANATNKQLHIIEGYNLTVQAQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXH4</accession>
    <name>A0A194QXH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXH4"/>
    <dbReference type="InParanoid" id="A0A194QXH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9624" checksum="ABAF0F6AC5B86AC9" modified="2016-10-05" version="1">MKMLWWMYGVPRLDTIRNELVLGSLGVRDIADKMQENPEADPKLDVVLKDKSECQVSDEGVEDRAKWKKLIRKADTTTMWITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZN8</accession>
    <name>A0A194QZN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZN8"/>
    <dbReference type="STRING" id="76193.A0A194QZN8"/>
    <dbReference type="InParanoid" id="A0A194QZN8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17301">
        <property type="entry name" value="PIPKc_PIP5KI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000001">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 5-kinase type-1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="81"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="937"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1169" mass="131348" checksum="2441BFCE12F05459" modified="2016-10-05" version="1">MASGDSDHIEVMDSSVTKKTDAGQAGAEDDDRDRTSIAEKNVLYDPAVGPSGAISKVHKSDRKIGHRRVGEGGEITYKKIQSSQIMASIQLGIQHAIGGLASKPERDLLMQDFMTVETTNFPHEGSNHTPAHHYSEFKFKTYAPIAFRYFRDLFGIQPDDFLMSMSSAPLRELSNPGASGSIFYLTNDDEFIIKTVQHKEGEFLQKLLPGYYLNLDQNPRTLLPKFFGLYCYQCNSKNVRLVAMNNLLPSSVKLHQKYDLKGSTYKRKASKTERQKNSPTYKDLDFMEHHPEGIFLEADTYNALIKTMQRDCRVLESFKIMDYSLLVGIHNLDEAQREKTEARKRTDSGQSDGEDEVEPKSSGLNRTRSINRQRLVAHSTAMESIQAESEPIDEEEDVPPGGIPARNARGERLLLFLGIIDILQSYRLRKKLEHTWKSMIHDGDTVSVHRPSFYAQRFLDFMGKTDTVSVHRPSFYAQRFLDFMGKTVFKKIPSSLKHSPSKRKSIAKPIKPLEEIDTPGRKLVGRTIKDYNPEILLRQTSRLSPRSSLRSSMSDFTDTTISTWNQKPRIPQMPTEYPSVLSDRLKIIDRDRIGTFQRRIDFDTSNLTSREAGPSYADNVYRSSIQDRMESLSDQLTKVLCTGAGSTHINGSLADSGIQTDNTSTSVPQIYIAEPQTNFPPVIKILKDASVDTRNENNLQDIPFIDDDDEEKQAKRRSNILEKHKSMSNIPEKIDEVSSREHSNERLSSSLNRAKSPTFVEKFKKFFMDIGLVKTDSASLTETPLREPSTLPKSLNSSYRTRSVTPIRSEAREASTLPKDMRFRKVRSTQTVYFRTESPIPIINSDMGSQTNEHVSVVQLNGDEHIRDSESERYVKEVVYVRSLDKAEIYSGNDSVSLSDVTAHITPTSVTSPVSTAAKVTQISTKTTLEPDVAFPAVLKGSQKQRVPPPVPPRGSPKAKRGGGHSQSGHEHKGDYSTLSVSVNDDPLKRIASSDDDFGFYGHDVKFKEFSACRVATSMSNYSDRIPKLGGSDDFLDYVEDEDIVTNRTNSGKDLSAQTNMMAKFNIDKVVREHLDTGDYDGISFTESSDEESIIAVEVNDYGDDSDEKVSNPKVTSKSKNPLHFIIRQKKQPKKEIKSTPKIVQDSSSERSLSPDIDPTTTSDIKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R077</accession>
    <name>A0A194R077_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Collagen alpha-4(VI) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R077"/>
    <dbReference type="STRING" id="76193.A0A194R077"/>
    <dbReference type="InParanoid" id="A0A194R077"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0176">Collagen</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="720" mass="70931" checksum="EBEC5E887A2A90E2" modified="2016-10-05" version="1">MSASLDKVLGDAMLLNYSLGAIFICLTAYTFTVVEDFYQSVRYFSFFMSLLVESFNQCIVGQVLSDHSENLTESIYSADWPNASQEVKKIMLMFMMRTQKPFKLTANGYLVMNLNTFSARQLLTKEQVNLWPVVNGDSESESYEDSGSSESYEYDSYEDSGSDEDNGLVGAAATENGRGRSGSASAIGAAQATENGQGGSGSASVHNAVQATQNGRGGSSSAIGLGSAQVVENGHGHSGSASASGGAQAIENGKGASASAASGAIAAVNGRSGSGSASTKSTAQAPNNAFGGVDDLGFGQAFAQGTASAIGSSSASAFTSAQTSVNSHTNVTGTRHKKRRRHRKKKHKGKKGHKKQGSSSGSTPGTSVPAGNKGIPGPPGIPGTTNPGSQGPEGGEVPGEGSVSTPGTSGPGGNIGPSGSSAPPGAPGPSIPGSKGPGGSKGPGGSPGRQTGTPGSGGKKGPTGPPGPPGPPGAPGPNIPGSKGPGGKPGSPPSTSEPGGHKGPTGPPGPPGPSGGPGPSTPGSKSPGGSKSPGGSPGRQPGTPGSGGNKGPTGPPGPPGPPGAPGSKGPGVNPSSPPSTSEPGGHKGPTGPPGPPGPPGGPGPSTPGSKGPGGSKSPGGSPGRQPGTPGSGGNKGPTGPPGPPGPPGLPTAPENKESCAVKIYRLGRIYRKTKSRFVYPIFRRLGRKTSYGRDDDYEDIDKENVYRNYLSGEKYCVCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0B9</accession>
    <name>A0A194R0B9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secernin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0B9"/>
    <dbReference type="FunCoup" id="A0A194R0B9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0B9"/>
    <dbReference type="InParanoid" id="A0A194R0B9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="399" mass="44782" checksum="2E527F3A5F6621BB" modified="2016-10-05" version="1">MGSPRSCDTFVVLPPLTKDNQVIFGKNSDRPQNEVQEVIYVKDRIRNSKLKCTYITIDESSEPLNSVILSKPAWMWGAEMGANDKNVVIGNEAVWTSNNEGEGDARQKRLLGMDLVRLGLERGNSAEGALNVITNLLEKHGQGGPCSEFDDSHFYHNSFLIADAKEAWVLETSGKLWAAEKITSGYRNISNGLTIMTKFDKHSRGLFVKAEATGFWNGQGQFDFMKCFSSGGDEKRQKEGERLLREGTAASCFGVKDMFNVLRHKESCICRGCEDTFPTQGSQVSALSANGLSVHWFTATPDPSISYFKPFVFTPNAQVSTYSESPNEPRREHHLYKLHAKYQAKENSEMITKILREMEDSCLSEIEEFLSNFDPENTSLEELDNLMKDCVDTEVKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0H3</accession>
    <name>A0A194R0H3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0H3"/>
    <dbReference type="STRING" id="76193.A0A194R0H3"/>
    <dbReference type="InParanoid" id="A0A194R0H3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="806" mass="88116" checksum="F3176AB48852DDC4" modified="2016-10-05" version="1">MTGCHKLARRTALDNFPKVQDELNQKRNRPRDMSLAEPPHTMEIAQILMSLLHAWGLDPDLDRVCESKLGLLRPMVPVCFGVVSRHGHMAVQLPTWLGSWAEAAAAAPTDPALLSSDLPPELLKQEKLTRLFTSKLHWELSTTLTTNHLLSIVALANTLMSMSNASFVPEQEVARRMHRPTTRTSSWGGDEEREEQLAAQQAHIKLIRPTTRTSSWGGDEEREEQLAAQQAHIKQGWSLLATLHCVLLPDKVVAAGAKSFKRPQVEMLARRWQHQCLEVRDASQALLLAELGRLGPKGRKQLVDSWAQFLPLYTHTESINPHAAQKEPVEKPEVESEEEEEEIVRKPSSLAELKRKQTTAVVLLGVIGAEFGQDIASEESEEEEEEIVRKPSSLAELKRKQTTAVVLLGVIGAEFGQDIASEGAAGSKRRKDGDSRKSSIVEGFTLSASNNLARLTALALTHLLLAPGSAKLPAHTPLRRAAVDLLGRGFAVWEPYLDVSHVLLGLLEMCSDADKLVPSMTYGLPLTPQADSCRTARHALTLIATSRSQHVEMCSDADKLVPSMTYGLPLTPQADSCRTARHALTLIATSRPAAFITTMAREVARCAAAAAGAPPPPAALALQRGRAEVLRGIELLIDRMHAEVAELLVEVMDIILHCVDQSHLKSKGLNEVFPAICRYNQVSHCPATRRIAVGSHTGQLALYELRAGRCQSLAAHGGPVTACAFSPDGRYLVSYATADNRLSFWQTTAGMFGLGAAQTRCVKCYSTAPMADVARLNPARLARLVWTNSRTVTLMLADGSETRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0K2</accession>
    <name>A0A194R0K2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0K2"/>
    <dbReference type="FunCoup" id="A0A194R0K2">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0K2"/>
    <dbReference type="KEGG" id="pmac:106715476"/>
    <dbReference type="InParanoid" id="A0A194R0K2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264802" evidence="4">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="181" mass="19148" checksum="0343852BBCC4DD22" modified="2016-10-05" version="1">MAVKFLVLACLVAVASAAVAPAPFTYHGAPVAYNAPITKYASVPVSQTDEDYDAHPQYSFSYDIHDAVTGDTKSQHETRDGDIVQGSYSVVDPDGTQRTVDYTADPQNGFNAVVHKQPLGVKVATVAKVSAPVAYHAPSVVHASPVTYHATPVAYHTAPVVHAAPVVHASPFAYSGPIYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2E6</accession>
    <name>A0A194R2E6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
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    <sequence length="341" mass="38004" checksum="FFCCBF2B655B1183" modified="2016-10-05" version="1">MRGRYGVVARHTGPISMGSIERPIRSPVVCLALHTRETGFVNAITAAGVTYAITRACTAGALLECSCEKVTYKYHVLPYLRSDTRETGFVNAITAAGVTYAITRACTAGALLECSCEKEVPKPRRGKVTPVPIPPSPVETERWQWGGCSDNIRFGLMKSREFMDSRYKKRSDNIKTLIKLHNHNAGRLAIKNNMRVECKCHGLSGSCTLRTCWWRMPAFREIGNRLRDRFEGASKVISNNNGEGFMPESPNLKSPGKKDIIYSEESPDFCTPNMKTGSLGTEGRQCNISSAGTDSCDQLCCRRGYKQTTVKESENCNCQFKWCCEVICQTCYIKRDIQTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3V7</accession>
    <name>A0A194R3V7_PAPMA</name>
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        <submittedName>
            <fullName evidence="11">Protein eyes shut</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGFBLOOD"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264898" evidence="8">
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            <end position="1199"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
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    </feature>
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    </feature>
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            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130690" checksum="ECF60999D547E537" modified="2016-10-05" version="1">MFHKYDLEFRALCWTLALIPVVSAGIACLSNPCLHGICIDDLNSTYMCYCIDGYTGVHCQTNWDECWSGPCQHGGTCLDGIASYNCTCPEGFIGWAGKFCEDQIDECESNPCQNGGMCIDIHADYMCACAYGFTGKSCEVQIEFCDENSCSNDALCVVEDGIRVCYCVPDYHGERCELQYDECLLGPRCMNGGTCIDGVDNFTCSCPPNLTGTLCECLIINEDHIDCEYVSPTPLYNTTTALVHTTNAEKITTEVTSTIATTTNNYTSNELTSQSEPWTTSTMFDFTSTTEAVSQTVSEKISREETTTLSYASPSETEETTTSTTEVFTLEQQTQKTISVEDSKTESSCKENCDKLTAPTTLTTSSEFETTLLNNQTTSIAVTYPTKVTIEFQNQTSTELTTTLTSTESTTKTTIEDVTITDHKIDTTEKMFTDVPTEYSSTDTSPTYTSESVETTTYFDKTTQVYTTVQSECSDAVCNNRGSCANTIHGIRCHCLFNYGGRFCEEKLSITTAAFGGNSYIVHHLNNTTSISIEFSAKTLITDGHIMHVDIAKGAYMELFLNSGLLKFKFSCGYQTMLLSELKTYVNKGYAMKIETRLDLYLNQQQCNATLHLNDTVAMSGGQIANISIVDQNIILYFGIIPDSNYTNNKPFIGCIKDLKVNNKSRDIFGEAFNAGEVTECSSLSCLSGPCLNGGTCNDQGDGYSCSCANGWMGENCKQSICEHNPCQSGGSCVRYPGSGFLCLCPYGKHGIFCEYNVEITRPSLAPIAPGVSSYLVYPLSAAALSSERFELRLRFQTADMDQIALLAFVGQSGRHGPRSHHLALTFVKGYLMLTWNMGSGPRRVFTSRAVGVRRGGHAVRVWRRGRSAGISVDGRYNVSGNAPAPPQHDKMTLLPYLYIGGHPSFNFAELPHDLPLHSGWRGCVWDVGGQAAGGRPAAGRGVGQCGVAQCTASSCNAPRGLCIHSPATYGCICNEGWFGPTCSSAQPVCGPRSHCRGTCVLGGDGRAHCDCPYGLTGENCEQDVIPIDVMFSGVRSYLRLQPRSISSVSLSLEAEIKPDKERGLLILVQTPHFYTALSLQGGLLEYRWTDRLSGLTSLVRSGVVASLRRWQRVRAGRYAARLYVWVDGALSTEPMLAHTYPHTASDADILIGGAQDLSTVPFDAMSGPSESYSGCIRNLHVNNVPLPLDQQNIRGGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R457</accession>
    <name>A0A194R457_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Male-enhanced antigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play an important role in spermatogenesis and/or testis development.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R457"/>
    <dbReference type="STRING" id="76193.A0A194R457"/>
    <dbReference type="KEGG" id="pmac:106714092"/>
    <dbReference type="InParanoid" id="A0A194R457"/>
    <dbReference type="OrthoDB" id="5593200at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009685">
        <property type="entry name" value="MEA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17005">
        <property type="entry name" value="MALE-ENHANCED ANTIGEN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06910">
        <property type="entry name" value="MEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="17248" checksum="3DF85821A80D45FD" modified="2016-10-05" version="1">MVCDGPDPPENSPNNLTPPPRHELINGNNEESDDEQTEYFGYEPLPQGPDGAITDFGDRDEDSDSTYAEDQEVPSQDVPAIEPIENVLVREVWSTPRSTDSIQMDNERAQEVMSAMANFALPEASIPEWAQSISEEQWKQTLNDRLERLRNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R491</accession>
    <name>A0A194R491_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WW domain-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R491"/>
    <dbReference type="FunCoup" id="A0A194R491">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R491"/>
    <dbReference type="InParanoid" id="A0A194R491"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="302" mass="34938" checksum="5D6BE0AA9DA4E6B4" modified="2016-10-05" version="1" fragment="single">FYLQTTQNSFNYFRTEYWQSTARKYCEFCKCWFADSKVCISFHENGKRHKENVQKHISQLSKKSAKEFKQKEKIDDEMKKMESAAMAAYLKDVKNNGDLTSKVINEMVKKSGGSAADITISCGTKDKSAPEWHEIKSESGSSYFWNTKTNETTWNPPDNYLSIAKQEEKKLKEEQPEKKQKKAKKQKQDECFKEVEALMKREKMKELGDKTKPSNSDGQYGPSLRPANPYGSWKPVVDECKESIDLQLPKGKEQPPPPVVVLPEVVQFKEKRVDSLGDGPVDFKKRKLNVQKRNIRQKLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4A4</accession>
    <name>A0A194R4A4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FGFR1 oncogene partner 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4A4"/>
    <dbReference type="FunCoup" id="A0A194R4A4">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4A4"/>
    <dbReference type="InParanoid" id="A0A194R4A4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186:SF2">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186">
        <property type="entry name" value="SIKE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="261" mass="30533" checksum="A7D553C1A5D1DA73" modified="2016-10-05" version="1">MVALKLILKLRLADVKAHYFTKKWSLGLPEPKPGLPLWSILGIILCQRLHDRMSLTIQQIILDAKRLAGRLKERETEADALLTETQSAYRQIHTMKQYKEEVDTLNEASRERPRGELIASIERESRLMRDVQRENGELRAALEDHRRALELIMSKYRQHTEKRIWESRIDFTSAINDKQQELIRQQAERINEMTSVMYKAVTLDENSDTRKEEELYQRLITENKGLREMLNLSRRYGSERSLAPPMEDKHVQTDGPPVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4V5</accession>
    <name>A0A194R4V5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4V5"/>
    <dbReference type="InParanoid" id="A0A194R4V5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF5">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="812" mass="90786" checksum="F821BBF42526E17B" modified="2016-10-05" version="1">MKEGPSASPRWRRTPPVACGSLATAAVRYGGQCLRRSTSCLPVNISNTWVLPEEGFPVFYRYFRDRISWYEADAVCQFHHANLVTVDTTAQYDAVRAYLKELDISSGVWVGLIRSNPEGDFTWTDYRGLSGDGYWSSAPDPRAAPLCAAADPTADYRWQARACGGPTVASFICELPVPQWALGNEGCMVRALPALTILYLPESAAVQLTADCGLAGVKRVQCTGNVKREDLLRDLSCAEEVESTSLNNLALNSTINESTTSTENQELSSVSVTEENLSIEHGNEHENLPSSVMSTPIPYNENVRQSMISASHSTSQPARYKTNNIILEKNINLNDMQNNNLQSNEIPDLVNNDKFLTNYRIQKMEDEENMQHKKLHDELARLGNFETIFTQPTDHFVPPLVMAKARISDDLNVLSLKEKHAQHFGTQDMIEKMNEEKKIPNMEEKYEISTERPHAIENLVGLTTEGVTKLKDTLKKDIIEISLLKKYKDLNANVTQISKSKTKKVNKETFVEIMNHESKPAFVNIPLKLKETTTLGTTVANEVYEIQNDSNMDLTVVLRETNDERQSQDLTNGTDEGIGKNTTRSIIEFVHPTTEIVDFFNGTHLNLQQTQEKSNKSETISEDISTNSGNGNDSKISDIPQTPDFTTKLPVFKDELINISTTSININIQDGVNKTIFSATEISTIRDDIHIADSKSSLDLPANTVDNANYTEITESSHMSTKPGSSIINSENQTDNLDHETSSTLYPVFSDVFNYTETVEEINDRPGDLETIDDFQSPLLSGANEPLQRPNRSRRPKQPNRINKFNPFRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6Q0</accession>
    <name>A0A194R6Q0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell cycle control protein 50A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6Q0"/>
    <dbReference type="FunCoup" id="A0A194R6Q0">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6Q0"/>
    <dbReference type="InParanoid" id="A0A194R6Q0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="47303" checksum="614E4778CC3B6CC6" modified="2016-10-05" version="1">MATSSDTSDQNVKSRRPAESAFKQQRLPAWQPILTAGTVLPTFFVIGIAFIPVGIGLLYFSDEVKEHVIDYTKCMKLNENITCAEYIKKNDMDSCICQINFNLTEDFKRDVYFYYGLSNYYQNHRRYVKSRDDSQLRGQLSLTPSSDCDPFGYAEEDGKLKPVAPCGAIANSMFNVLTPSSDCDPFGYAEEEGKLKPVAPCGAIANSMFNDTLMVRSLDWDIEVPVLRTGIAWTSDKDIKFRNPPGDLKTAFANFTKPVNWRRPVWQLDLNNTDNNGFQNEDLIVWMRTAALPTFRKLYRRVDHSQYGFSTGLVKGPYLLRVEYNYPVTDFDGTKSFIISTTSLLGGKNPFLGVAYVVVGTLCLLLGIVLLVIHVRCSRRYPPPIAHTYFVDEQTTSHNVNEYSTTEMINVNPRTPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7C5</accession>
    <name>A0A194R7C5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7C5"/>
    <dbReference type="InParanoid" id="A0A194R7C5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="111" mass="11988" checksum="F4CDF87BFDBD62AA" modified="2016-10-05" version="1">MRSHRGKYTTCIHKVAAAGLVTSFTPGTDWGTRQRRPSPDTSIYLRPVGIECGTCRCRAAIDAIILLSVNKRHNDVKGAACPNMSVRTGDGCISSRAADRRNSGGDDGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7I5</accession>
    <name>A0A194R7I5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7I5"/>
    <dbReference type="STRING" id="76193.A0A194R7I5"/>
    <dbReference type="KEGG" id="pmac:106712862"/>
    <dbReference type="InParanoid" id="A0A194R7I5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="640" mass="70101" checksum="82B876930605D287" modified="2016-10-05" version="1">MPTPAVGIDLGTTYSCVAVFQHGKVEIITNDQGNRITPSYVAFTDTERLIGESAINQIAMNPKNTVFDAKRMIGRKFNDPKIQQDIKHWPFEVISDNGKPAIVVQYKKERKKFTPEEISSMVLSKMKQTAEMYLGGTVTDAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKDLKGEKNVLIFDLGGGTFDVSILQISEGSLFEVKSTAGDTHLGGEDFDSRMVDHFSQEFERKFKKNITSNPKALRRLRTACERAKRTLSSNTEASIEIDALHEGIDFYSKITRARFEELCSDLFRQTLVPLENALKDAKMNTREIDDVILVGGSTRVPKIQRLLQEFFGGKTLNLSINPDEAIAYGAAVQAAIISGSQEVRLQDVLLVDVAPLSLGIETAGGVMTKLIERNTRIPIAQNKIFTTYSDNQPAVTIQIYEGERALTRDNNLLGTFNLTGIPPAPRGIPQIEVSFDIDANGILNVTAEDRSTGRSERITISNDKGRLSKKEIEKMLHDAEVYKAEDEAVRKTVEMRNQLEGYIFGCKTAAENSGGRLTNSERTAVVTECNNQLHWLESNPNAPISQLEEHLKALQAVCQPAMMKLHGAGAGAGVGLGGPGVRPSTPGRSGPTIEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7U3</accession>
    <name>A0A194R7U3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7U3"/>
    <dbReference type="FunCoup" id="A0A194R7U3">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106714222"/>
    <dbReference type="InParanoid" id="A0A194R7U3"/>
    <dbReference type="OrthoDB" id="8190653at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF27">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="577" mass="66623" checksum="DC67E21054E18B5F" modified="2016-10-05" version="1">MVVCELDKEVSGELLGKKLPAWQALFLHRVLPSCGGLIVYLTVICYDITLIYEHFRNGDDGLAVFCIVLMVFPSVLSLVFTLASPPPGLQTELAAYTVKIEKNDIKWVLMQIINAIFFPIAAIGRYCYLIFWWTESVFASHSNDEERTEEALSLARAASPLELYLFLQAFIHSAPHAIVNILDLMWRFSNPSYDKGSIQSISIIVSCMRMASTATFYRRFEREKICGRKYPWKDKEKVEKCENENVVVENNEDKQSEHIYETIKRQSSISDKSKNSRSGANDDLIQFSPRNSEMASSFYNDSAFDSDSSSSILASTDHGNLESDDEYVRPITIIDRVAPRRQTREYVIEKVYVPPPPAMDAPRPGSLAQWAEKFVENAENIPTWLSAPPRRKHWEIVHSEPDIPRRVPRSFVRGLEPQDVTAGLVQYLGWYAFFISRLLSIAAFINFFPFVAIIILFSHYQVTLLFLIVPQAPTVKRAFYVFLAFIYLFCLMEFKIRFRHVRVWHMVWIVTCTIENIIFTALWATIDNYLDNWWKSFVVYVTFGSMILSYTCLLVYFVLLKPREAIVYINNKEMVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R823</accession>
    <name>A0A194R823_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine incorporator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TDE1/TMS"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="437" mass="47964" checksum="14CF694723D2D3FB" modified="2016-10-05" version="1">MGAVLGLCSAAQMACCLTSAACSLCCSACPSCTNSTSTRLMYTIMLLLMMIVACVTLAPGLHEQLKKVPFCENSTGIVPGNFKVDCDQAVGYLAVYRICFATCLFFVLMALIMLGVKSSKDPRAGIQNGFWGIKYLLVIGGVIGAFFIPEGQFASTWMVFGMIGGFFFIIIQLILIIDFAHSWAERWVSNYEETQSRTWYAALLLSMLTCFTLALTGIVLLYVYYTKPSGCDLSKFFISFNLILVVIASAISILPSVQEYQPRSGLLQSSVVSLYVMYLTWSALSNSPAECNATISENQQVTITFIIQLSYSELRVFHKSHDVFSNFFPSCPLVISGYGSVEGDGGEAARGAGDAEAKVVDNEGDGVAYSWTFFHVVFALATLYVMMTLTNWFNPSSQLSKENVASMWIKITSSWLCIGLYIWTLVAPAVFPDRDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
    <sequence length="96" mass="10985" checksum="1C004E9E159492B0" modified="2016-10-05" version="1">MPRRRNGEIPLPDGWDYARDFDGKLYFIDHNSRKTTWIDPRDSGLDAKINVQFVVIGTCLDLDGRFGSAREVRCIESGLEDGMHCIGKLFEVNDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R946</accession>
    <name>A0A194R946_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin-5</fullName>
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        <name evidence="9" type="ORF">RR48_10964</name>
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        <name type="scientific">Papilio machaon</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
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                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">Ya'a_city_454_Pm</strain>
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        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="354"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1093" mass="122067" checksum="38A4A07AC5C0866D" modified="2016-10-05" version="1">MAGDQAQFYQLLNTLLSTDNDIRQQAEDAYNNIPTETKVVHLVGAIQNGDISEEARQTAAVLLRRLLSAEFFEFFPKLPFDQQTMLREQLLLTLQMNVSQQLRRKICDVVSELARNHIDDDGVNQWPEFLQFMFHCASSQNPDIKEAGIRMFTSVPGVFGNRQNENLDVIKQMLLSSLQPTETEALRMQAVKAVGAFILLHDKESTIQKHFSDLLLPLMQVVVQSIEKTDDDSALKVLIELAESAPRFLRPQLETIFEVGIKVVGDTEADDNWRQLALEALVTLCETAPAMVRKQVPVAIRRLTPLVLAMMCELDDEPDWSVQDDVADDDNDLNYVTAESALDRMCCGLGGKIMLGLIVGQVPEMLNSEDWRKRHAALMAVSSAGEGCHKQMEQMLDQVVSAVLTYLTDPHPRVRYAACNAIGQMSTDFAPNFEKKFHSKVVPGLLLVLDDSENPRVQAHAAAALVNFSEDCPKPILTQYLGPLMGKLEIILTTKFKELVERGTKLVLEQIVTTIASVADTVESDFVQYYDRLMPCLKYIIANATTDELKTLRGKTIECVSLIGLAVGEEKFMADASEIMDLLLKTHTEGEQLPPDDPQTSFLISAWSRICRIMGKKFARYLPMVMEPVLRTAAMKPEVALLDNDEIKIIEGDLDWHFVTLGEQQNFGIKTAGLEDKASACDMLVCYARELKEEFADYAEEVVKLMVPMLKFYFHDNVRTAAAESLPYLLECARTRGPQYIQGMWAYILPELLKAIDSEPEQEVQVELLNSLAKCIELLGTGCLSTESMEEVLRILNKLLTEHFKRATERRQKRADEDYDEVVEEQLADEDNEDVYGLSRVADVLHALMSAYRENFFPHLDSLLPHLIQLLAPGRAYSDRQWAICIFDDVIEFGGPACIKYQDIFLEPMLSGLVAAEAEVRQAAAYGCGVLAQFGGVQFAAACARAARLLADVVNAPDSRNIENLNATENAISAVAKIIKYNHTQVDRDQLITHWLTWLPVVEDVEEAPHVYSLLCELAASGHPALATADAPQRVVATLAEAFLRDAVPTDNPVYAQMVGLARQIQSNAELFNSCVMQLSSEHQEALKIALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9C9</accession>
    <name>A0A194R9C9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein 27C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9C9"/>
    <dbReference type="FunCoup" id="A0A194R9C9">
        <property type="interactions" value="1767"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9C9"/>
    <dbReference type="InParanoid" id="A0A194R9C9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000427">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 27C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="53109" checksum="C7ECD4987C109716" modified="2016-10-05" version="1">MNPDMDDDEKGKLFVGGLSWETSQENLQRYFSRYGDVIDCVVMKNSESGRSRGFGFVTFAEPSLVNVVLQNGPHQLDGRTIDPKPCNPRTLQKPKRGGGYPKVFLGGLPSNITETDLRMFFGRYGKVMEVVIMYDQEKKKSRGFGFLSFEDEVSVERVTQEHFINLNGKQVEIKRAEPRDGSGKLGSGSGGMGGGAMGGAPGDAPAAGQWGPPQAAPINMIQGHNGQMGGPPINMPMAGPNIMQGYQGWGTSPGQTSYAGYGAAGGGAGPGNYQGWGAPPAPQAPPHAPAWPATNNYTQHAQPPAQGYGSYGWGTSPGQTSYAGYGAAGGGAGPGNYQGWGAPPAPQAPPHAPAWPATNNYTQHAQPPAQGYGSYANYSSAPAGASAGGSWTTWNMPQNSNSTGSGSYVPLSESGEMYGRGAGGGGGGAAPALTGALSSAALNKSSSDYSTYQQYPPAYQQDQGSSYGGSRTYGGEYHGAAGGAQPPGVHAVPHHAPKHFAAQDFNKEWNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9L4</accession>
    <name>A0A194R9L4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9L4"/>
    <dbReference type="FunCoup" id="A0A194R9L4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9L4"/>
    <dbReference type="InParanoid" id="A0A194R9L4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19744">
        <property type="entry name" value="bHLH_TS_dAS-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="23163" checksum="0560F03C647A76DA" modified="2016-10-05" version="1">MEKRMVPIAPAPEKNYVTHDTPPNLQYRKKVHFRTNPYTGPQAASIARRNARERNRVKQVNDGFNALRRHLPASVVAALSGGARRGSGKKLSKVDTLRMVVEYIRYLQQLLDESDAALGITRDQENRENIPSSNSQPTTTLDMDDGFFYGNDSPCSEKADSPAPSECSSGVSSAYSAVDRYEVSTQQQLGPMDEDELLDVISWWQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC11</accession>
    <name>A0A194RC11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Corepressor interacting with RBPJ 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC11"/>
    <dbReference type="FunCoup" id="A0A194RC11">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC11"/>
    <dbReference type="KEGG" id="pmac:106710749"/>
    <dbReference type="InParanoid" id="A0A194RC11"/>
    <dbReference type="OrthoDB" id="6253837at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="29256" checksum="76CC446C964587EA" modified="2016-10-05" version="1">MGKGFNNYMCKKFFHPASRDNLKRVWMAEQKTDAYKKKQEELRVQYEKEQELHENKALLSKDSKDKLSLNFMYEPPPGVKKEREREDNEPEYKFEWQRKYNAPRESYCKGDNEIRDQPFGILVRNVRCIKCHKWGHINTDKECSMYTLSMSEARALQAASSNTQEEEEEKPDVPTLMQQMRDTGLVMKPGALPLAATKVDDDDPSGLTEMDLISQLTKKQKKKLLKKLEKMEKKKIKKEKKHKHKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCW1</accession>
    <name>A0A194RCW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YTH domain family protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCW1"/>
    <dbReference type="FunCoup" id="A0A194RCW1">
        <property type="interactions" value="1592"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCW1"/>
    <dbReference type="InParanoid" id="A0A194RCW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="5">
        <location>
            <begin position="353"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="630" mass="70643" checksum="57DE4B6333F40583" modified="2016-10-05" version="1">MKGQGNQVTNVPKEQQLESGGDELAEVSWRHQQQPSYAPPISSAADPYSAAGYYGTTALPYQAFGVGDGTWSTNGTDPMTFLGGYNPHDSYGMDGVFGPSTTPFSTAAFGQPASTFNYFHGNGDYSTWGQLGRAKQYDDYYRADGLYVPDGIKAVDSGVQALSLGEHKTDKERISELKDVSSGSQPKKMTWASIASQPAKPAPTSQTVGLKKKGPGMPPPPIVPGKHNMDISTWDAGKSAPVVTAPPPPPLQPPPVPAPLPMPPTPAPAQPPAPAPASLQRGPPPQHQPPPPAWAHAPRAPPPHQPRPPLPAPSIPPPQVVTNPAPTPHPVLDELRVKNDYNPKEFDLSAPLARFFVIKSYSEDDIHRSIKYEIWCSTEHGNKRLDAAFREREREGGAVFLFFSVNGSGHFCGMARMTSAVDYNSNSNVWSQDKWKGQFRVRWIYVKDVPNVQLRHIKLENNENKPVTNSRDTQEVPHAKGLQVLRIMHSYCHSTSIFDDFIHYERRQEEEDSRKVPHHPQDNNREDHEGGRGYRNYRDYRDHREGREGRDGRDGRDGRDGRDHRDARDHRDARDPRDHRDPRNPRDSRDHRDDRDGRDMRDHDYRDRDSNYRSHHKDRDGSRGRGRPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD60</accession>
    <name>A0A194RD60_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_08660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD60"/>
    <dbReference type="FunCoup" id="A0A194RD60">
        <property type="interactions" value="1902"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD60"/>
    <dbReference type="InParanoid" id="A0A194RD60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="42"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="638" mass="71512" checksum="6E097FDCCB44EE7F" modified="2016-10-05" version="1">MSHLPLTKNMLSSVKVFNKPFVNLVNTRHLMSKQLVYNEFGDPLKVVKFKECQVPPLGPQDVLVRMLAAPINPADINTIQGKYPVKVNLPSIPGNEGVGIVEEVGKEVREITAGNKVILTKSVQGTWRDIALFKENVLKVVPDELGIVEAATLTVNPCTAYRMLMDFQPVKDGHVVIQNGANSACGQNVIQICKAWGVKNINIVRNRPEIEELKNYLQCLGATYVLTEDELRSTNIFKDKLIEKPTLALNCVGGKSSLEMLRHLQHSGKMVTYGGMSREPVSIPTSAFIFKNLSFYGFWMTAWNEEATPVEKNKMMNDIISMMTCDNIKGPIHKMVKLEDYQEAIGNALSPQGFTGCKGCCLPSLPHVPGDEGVGEVVEIGRNVCAVKPGRRVVVTSRFLGTWRYYGTFHERDIHIISPLIPLPEASMITFAPCEAYRMIKDFRHISPGETIIQNAANSPCGQYIIQLCKVWGINTINIVANRCGYKEMKQHLLNLGATAVYTLEEAEELTTFDTSVTRPVLALNCLGGRYEDVLLNILDRFGAIIYYGCAYDLPMLKQGWRCDVSFYRFRLCDWNAYATSIERSTMLNEIIQLTAIRRLKSPSYEPVQLCDYVRAFSNTCHCEAFSNINYVFDFTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REN6</accession>
    <name>A0A194REN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PR domain zinc finger protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REN6"/>
    <dbReference type="FunCoup" id="A0A194REN6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REN6"/>
    <dbReference type="KEGG" id="pmac:106709909"/>
    <dbReference type="InParanoid" id="A0A194REN6"/>
    <dbReference type="OrthoDB" id="9998363at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000616">
        <property type="entry name" value="PR domain zinc finger protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="36788" checksum="7286E98142938103" modified="2016-10-05" version="1">MRTLARRGLPSGACSAAFGTRELRLALQHALFTPHNVYVDLDVSGRLCARGGPAGAAVCANLAPASPAATLLLCATSHSAPQQLGSAPETTEAGCLRLRLQAEAAPLQELQIWFDDTTLALLDMPFLSLKNIQGKKNYVCHDCGVEFEQPNPLKIHLFLKCGEYSIGAFWQTCLEVLERATSQRSSAFRPYNISSVQHSVSPMPHWPLLPLPADDAASAAVEALAAAWGKSRGGHTCLYCGKLYSRKYGLKIHIRTHTGYKPLRCRHCLRAFGDPSNLNKHVRLHAARAPHASQDSAPHACPRCGKPLARRRDLERHMRARHSHSPHISTTSPDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RES5</accession>
    <name>A0A194RES5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RES5"/>
    <dbReference type="FunCoup" id="A0A194RES5">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106709976"/>
    <dbReference type="InParanoid" id="A0A194RES5"/>
    <dbReference type="OrthoDB" id="7669009at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="36111" checksum="DF73B33012781752" modified="2016-10-05" version="1">MNSVQEEKPTETAKAHVRELRNTELVSRLLAATPPYLYSALPLQPHAFFFSEMLRSFVNARHGCRPQQYHRRFKRRAHKYFAENETEWRREWPKQDEEKKEPEPRPEVPLELTVDKHSPKVDAKSSGSPGPPSRQSTYVDVGTEELPKPSPCTRNPENVPAPNLILPPPPPMWYPPLYNPQFGVDPLNFFIDLRVSGHIYDRKRTATEGVETTLPQEARHDESVTDKRLGRDLGQRPRHISAFSVPIRDQTDTSNKYYDQSVHAGSNNGTSHIMKNLKGLYEKLHDTQNQNAQKLNDNEETKDDSSDLDEDIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG20</accession>
    <name>A0A194RG20_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Protein kinase C</fullName>
            <ecNumber evidence="2 16">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">RR48_08133</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Ya'a_city_454_Pm</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 16"/>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG20"/>
    <dbReference type="FunCoup" id="A0A194RG20">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RG20"/>
    <dbReference type="InParanoid" id="A0A194RG20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="229"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="373"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="632"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="379"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KPJ16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="702" mass="80046" checksum="237E308DC591C3BB" modified="2016-10-05" version="1">MICVSACCRGFGKQGFQCQVCSFVVHKRCHEYVTFTCPGADKGADSDDTRTRHNFRVCTYSSPTFCDHCGSLLYGLLHQGLKCQACDMNVHKRCEESVPNLCGCDHTERRGRIQLSVSCHGNKLHVEVKQGRNLIPMDPNGLSDPYVKLKLIPDSDNVKKKTKTIRSTLNPVWNETLTFDLKPEDKDRRLLLEIWDWDRTSRNDFMGSLSFGISEVGRNLIPMDPNGLSDPYVKLKLIPDSDNVKKKTKTIRSTLNPVWNETLTFDLKPEDKDRRLLLEIWDWDRTSRNDFMGSLSFGISEVMKSPADGWFKLLTEEEGEFYNVPVPEEGADLAQLKTQMKATNVAARRPPPPPDREVPHNMAAADVIRASDFNFIMVLGKGSFGKVMLAERRGTDELYAIKILKKDIIIQDDDVECTMVEKRVLALSSKPPFLVQLHSCFQTMDRLYFVMEYVNGGDLMFQIQQCGKFKEPVAVFYAAEIAIGLFFLHSRGIVYRDLKLDNVLLDQDGHIKIADFGMCKEGITGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDNSVSYPKTLSKEAKDACKSFLTKNPAKRLGCAPRGDEDVRTHAFFRRIDWARVEARDVQPPFKPKIKHRKDVSNFDKQFTQEKTELTPTDKLFMMNLDQTEFMGFSFLNPEYVQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGI8</accession>
    <name>A0A194RGI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGI8"/>
    <dbReference type="FunCoup" id="A0A194RGI8">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106709048"/>
    <dbReference type="InParanoid" id="A0A194RGI8"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF96">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="490" mass="53566" checksum="7701E9A4C3633985" modified="2016-10-05" version="1">MKILMRADTHYSIVVRDTEYEKPKYTCSQVLAAVAVSMGSMIVGFSSAYTSPALVTMENSTSISVSEEQASWVGGLMPLAALVGGVIGGPLVDYIGRRRTILSTAIPFFIGWILIATAKIVHLVLAGRAICGLCVGIGSLAFPVYLGETIQPEVRGTLGLFPTAIGNIGILICYVAGKYLDWSQLAYLGSSLPIPFLILMFMIPETPRWYISRGRTEEARKALQWLRGPNTKIDNEIRDIALSDAEIGKDSSMAELFSLKYMKSIFICLGLMAFQQLSGINAVIFYTVKIFKMSGSSIDENLSTIIVGLVNFISTFIATALIDRAGRKMLLYISSVTMTVTLIVLGTFFYVRDTLNMEVSTLGWIPLTSVMIYLLGFSLAFGPIPWLMMGEILPAKIRGGAASICTAFNWLCTFTVTKTFHNIIVGIGPSGTFWLFGSICFIGLFFVVVCVPETRGKSLEQIENKMTGRKTTRTRRMSSIANIKPLPCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHE3</accession>
    <name>A0A194RHE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intraflagellar transport protein 88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHE3"/>
    <dbReference type="STRING" id="76193.A0A194RHE3"/>
    <dbReference type="InParanoid" id="A0A194RHE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="663" mass="71292" checksum="778892B014B8BCE2" modified="2016-10-05" version="1">MLGSRYTMSRHGYDSKPRTALVIDDEDDLYSGFNEVAPALDTRTLREDQTFQQVVRTAGIGRQTTSRMGTGVFGMGTGRIRGSSRAGTATRPMTALRAAGYTSATRDTPLKDDRREDSIEDKIQQMERRIMSLVEESCMLSAKREEDDEAPTKREYDLAQALSKAQEASALERQLIRMQEQANMGDTHNLDLTFAVLCNLAGQYALNEMYTEALNTYQLLTRNKLFPHANRLKVNMGNIYFKMGEHPKALKLYRMALDQTPTAEKDLRMKAMHNIGLLLVRMGKFRDAVTNFQHIMHEQGDFQTGLHLVLCSVALNDAEAGKAAFHAMLDVEPATYHHDIPIDDENDAYECVLRDVVRGDRLSQWSRRAAAHAERCLALAAAALAGPAARDDDVSASWCAEALRGYSGGSAGARLELGGALAALRTAAAPAGSGGSALAAGARVLQRLKAVARAHHEDRVLRAEASADAAFVAYALGKWSEAKSLSEAAARDDPYSCSARVCGALAEMAAVRGGAGAGAGAGAGDGVREAAGDAARRLLAATHLDPADLVAMHDLVLFSMIPSIIYKRRHDDGVALCMEQSGEVGGAEARWQRVRAGAGGTLRSLAAAGLARLAHANAADPSAADHWYSMIGSWDAGVSCALAQLHAELGDPQTAKHHYQDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJL5</accession>
    <name>A0A194RJL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJL5"/>
    <dbReference type="InParanoid" id="A0A194RJL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265251" evidence="3">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9199" checksum="BE98165A661DF441" modified="2016-10-05" version="1">MGVLTRFLLVTVLLPCVLGQAQAECFGAGSVAGAAIGAFLGALLLVAAAYYVRKLYWKSRKGRCTERGTTGLQITQPHVAPPPPKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJM0</accession>
    <name>A0A194RJM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heterogeneous nuclear ribonucleoprotein U-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJM0"/>
    <dbReference type="FunCoup" id="A0A194RJM0">
        <property type="interactions" value="1536"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJM0"/>
    <dbReference type="InParanoid" id="A0A194RJM0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="315"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1155" mass="131212" checksum="057ADDED7CB3A1AE" modified="2016-10-05" version="1">MDPSKMKVVDLRSELGALGLDTKGNKAALVERLKKALETKTGKVFAETSILDTSTEDIDEPATPRKVNPAARVTRRSSSSRLATPAKQPIREDPPEPIEEEVKMVSEEPKEPEPEVVKEESPKKIEPPPKEESPKEPDVENTKEVQHEQESECVAMDQDKPDEQVSAPDLYEPESPNEDTNDVAEGSQEEKSEAQEKEEEQKMEHDGEDDSGSRDRKDSDEGRDGDRDRELTEEEEWALLNERLLIKEQERLEREKIQAEEDARKFEEMSKDPIKLQRLKRKQEKKARWSNFYKTVAVTNEVLTPPIEEEEKLLKKAETAIKVPEPEVNDDKVTLSWYDSDLNQFLELPDLNSVVPMNEGALAHAWAGSRATHGVTTGRVCFEVRVGAVVTTTETTEKEVISNGLRVGWSTDDSSLHLGDGELSWGYESTGRAVNNGEFKDYGKLYTEKDVIGAYLDMESTPCTISYTLNGEELGVAYEFDKALLGDRPIYPHILTKNICYKVNLGYERYNLLTRTKVVRQRVEVPIEQVIEEKKARQAEIERLKEEANRRNKERKEKDRKEREERQKKREERERSSRERKEKEAEEKRERGEEPEGEGKEMQEEQDAGERQEKADIEESAEQAKENGDSEVNNEPMETDQPESQESQAKEEKKEATSDKEEEKQTTPNKEEEKQATSNKEEEKQPTSNKEEEKQEEAKEEPSAEAEKEVTEDDFLKGILLDKRMKSVIRYVVEEELDGEEASMLPGYVLMAHAQTLPGPRPPPTTADCESAWPLQRRPDVQNMAITCARRSGGRGYLPILCRLHLLLGVILMVGMPGSGKTYWAKNHIAAHPEKRYNILSTGALFDKMKVDCKPFRSSYEGRWDAMVTKCAKCVLKLLEMARGRRRNYILDQTNVYPSAQRRKLREFDGYRRVAVVIVTDEDTYKERHKRREEADGKEVPDGAIVDMKANFTLPEKGTWLDEVIYPELEEEEARKILEGFHKEARAAGVVREREKRERSASRDGHPPHKRARDERRHSRDDRRPRDFPRDREDRWGGGGGGGGGGGGGVGRGGGQGRWGPAARGAGQTRWGAGNGRDRGGHVPPGRFDRQWGGPQHNRNNEFGRNDRDNFRGGRGGPGMRGERGRGPPPGDASRFGRDRANNRGPQQDKRPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJV3</accession>
    <name>A0A194RJV3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_07103</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJV3"/>
    <dbReference type="FunCoup" id="A0A194RJV3">
        <property type="interactions" value="1408"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJV3"/>
    <dbReference type="KEGG" id="pmac:106708028"/>
    <dbReference type="InParanoid" id="A0A194RJV3"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ17615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10805" checksum="F162B92A220C5099" modified="2016-10-05" version="1">MAVPQLDPAKLQLVQELEIEMMSDMYNRLVTTCHRKCIPLKYHEPELGKGESVCLDRCVAKYLDVHERIGKKLSNMSQGDSEDLTKINLQETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK25</accession>
    <name>A0A194RK25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK25"/>
    <dbReference type="InParanoid" id="A0A194RK25"/>
    <dbReference type="OrthoDB" id="8176709at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265249" evidence="1">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="391" mass="44586" checksum="93E6E51C2B486671" modified="2016-10-05" version="1">MLRKSIFTICLFCVSAQALASSDDKFIKKYAMMKIYESCFGPEVVKQIREEMKDAYAKCSIPPSFEESPNPPQMSSVLLGKLPPGFSMDPSTQTITKPTDGASLNQDNDLPNMDAKPQKQPPMAGVLSFRPLTPNFPQQAIPQAGIPPYMMQNPQFRPFSPAAPFFQTPYSAPGMFYPPGLPYNPYAYPQQFQQAFYQQPFFGAGRMALGTRQMKSYESPRDLDIRDRLELISRGPSAGRLRNVTCVMQELGYIDHNLEPNYEQITQRINNLPVPTALKTDIQDGLQFCQKFSQCVPEIKRDVAPLSQELIKPMFFFRCYKHKKLEACIMKDIRERFTSEDELDSESDFRSARSVREDSLPDPRFEALDEMAAYFYDYLSGSTGMDYDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL56</accession>
    <name>A0A194RL56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL56"/>
    <dbReference type="InParanoid" id="A0A194RL56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="62" mass="6912" checksum="FBD447816FFF3FBB" modified="2016-10-05" version="1">MQENINVRRIDDRARQIVDKASVNIGVGTKIHVGCGPCASRRKAARAPTALCLRSQTYRLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLV9</accession>
    <name>A0A194RLV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit Tim16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLV9"/>
    <dbReference type="FunCoup" id="A0A194RLV9">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLV9"/>
    <dbReference type="KEGG" id="pmac:106721138"/>
    <dbReference type="InParanoid" id="A0A194RLV9"/>
    <dbReference type="OMA" id="AKYLIQI"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="13596" checksum="EA11520879817207" modified="2016-10-05" version="1">MAKYIAQIIVLGAQVVGRAFARALKQEIAASQEAAKRAGGGPEGARRAAANASTGLSLEEAMQILNIDKLDPEKVNKNYEHLFNANDKSKGGSFYLQSKIVRAKERLDVELKPKGSQADASQSKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM00</accession>
    <name>A0A194RM00_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_13867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM00"/>
    <dbReference type="FunCoup" id="A0A194RM00">
        <property type="interactions" value="1775"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM00"/>
    <dbReference type="KEGG" id="pmac:106708738"/>
    <dbReference type="InParanoid" id="A0A194RM00"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000876">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="G" evidence="11">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="38632" checksum="B218BEF5790428E7" modified="2016-10-05" version="1">MAVRFDAAAYNFRKKCPYVRKDLLRWFPGHMNKGLKQMQRKLSSVDCVIEVHDARIPFTGRNPVFTETMLGAKPHILVLNKRDLTISSLLPKIADQLKAEENVQNVVFTNSKDQHCRGLKTLKPLMVDLIKNSNRYNRSEELDYNVMIIGVPNVGKSSLINMLRSKNMKIRHALPVGAVAGVTRSLMTKMRINDDPKIFMFDTPGILEPSVTDIEMGLKLALCASLQDHLVGEETIADYLLYWLNSHAKFKYVDYMGLEEPCDDIQKVLISGAVKYNRIRRVRDFDGTTREVPDLLESARTMIKAFRTGELGRIFLDIDILKFRRKPEIEEEMEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMD5</accession>
    <name>A0A194RMD5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin B12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMD5"/>
    <dbReference type="InParanoid" id="A0A194RMD5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23717" checksum="20DFC422D21714FC" modified="2016-10-05" version="1">MPGQQGNIVHAEDLEELEKRLLSSDSTTAAWNRLLRTLLPRLGLELQIPRFSHKSTFNITSTLQRMGLKDLFDAEHADLGGLNGPSKDLYLSDMIQSNTFVTCGENVIGEQHHIEQYPELQKRRSARWVHGWDEPRDYQRAFHDPHDVGEAMHLPLHLRPRQARLPARNAQPARLKFDRPFLFFVRHNPSGMILYVGRYNPRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN97</accession>
    <name>A0A194RN97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inhibitor of growth protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN97"/>
    <dbReference type="STRING" id="76193.A0A194RN97"/>
    <dbReference type="InParanoid" id="A0A194RN97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="17082" checksum="E50B2A7C3C66F700" modified="2016-10-05" version="1">MTSALYLEHYLDSLQHLPIELQRNFKLMRDLDDRAHGLMRTIDLMADELLPNIPKMDDETKKEKVNTIQGLFNKAKEYGDDKVQLAIQTYELVDKHIRRLDSDLARFETEIQEKVMSSRTSQPGADPETNTTTVKKGRKKHKAAFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNJ5</accession>
    <name>A0A194RNJ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RUN and FYVE domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNJ5"/>
    <dbReference type="FunCoup" id="A0A194RNJ5">
        <property type="interactions" value="1480"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNJ5"/>
    <dbReference type="InParanoid" id="A0A194RNJ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="706"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="747" mass="84913" checksum="EA0607A4A89DA413" modified="2016-10-05" version="1">MASSRDKQSEVSPATSTSSVRSQFLERSPSLSSTKEDKWPELLLSRPDKSYYYSTKSPLPELDVPSEIRRNSGADVEMAGAQDTIYLCNFRVSVDGEWLCLKELHDIEMQDSFTRPNENGAITSPDDPMHSLMARDPVVIERSNLVNISKLIVKELIEQSLRYGRMLDSDHLPLHHFFIVLEHVMRHGLKPKKGLLGPKKELWDILQMVEKYSPEAADITASVRDLPTVKTAMGRARAWLRLALMQKRLADYLRILLERREETLEEYFEPHALMLNEEAVIITGLLVGLNVVDCNLCVKEEDLDSQQGVIDFSLYLRGSNSSNDIAGNGNNANNEPKQRHINTMLDQKNYIEELNRHLNATVANLQAKVESLTTTNALMKEDLAIAKNTMITLVEENNQLKHALGQDITKDSRMKITEVLSEEEEKHSVKSSSSDKSKNEKDTEMGKLLDEERKKNMELQKELDLQISLKAEMEVAMKLLEKDIHDKQDTIISLRRQLDDIKLINLEMYKKLQECEMELTQKGEMVSRLQGKAEQIGKILHNLEKYNHFLGPDHELVKALRSPSSETNAAERLDTRTKKDEGPPSKKLNLQEIPPFRKNNSECESSLKHKTELIAKLEAKTESMGSTIHQLDEKLQEDKLIKKNLEESARSLGQKAAAAETRAVAAEGDLKIEREWRISLQDSMMRDRDKISILTQEVESLKSIGKHHCRRCGHIFCAACSDKTVALPGNTKPVRVCDTCFNEVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNR2</accession>
    <name>A0A194RNR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cryptochrome-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_07144</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNR2"/>
    <dbReference type="STRING" id="76193.A0A194RNR2"/>
    <dbReference type="InParanoid" id="A0A194RNR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF17">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="12" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cryptochrome/DNA photolyase FAD-binding" evidence="18">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12519" checksum="2F251A1FAA9452E5" modified="2016-10-05" version="1">MTALLDWSECACPVRRYVPELARVPVQYIYEPWKAPIDVQERANCIIGKDYPAPMVNHLDAAARNKNNMKELRRILEKAPPHCCPSSEEEIRRFMWLNDDTESEVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPY9</accession>
    <name>A0A194RPY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPY9"/>
    <dbReference type="STRING" id="76193.A0A194RPY9"/>
    <dbReference type="InParanoid" id="A0A194RPY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="18517" checksum="B3911C5111263E83" modified="2016-10-05" version="1">MQLEETVIDDGEFNMDELMTFNRPPLDHDYQLVKSFESKLPSGYRDLPIDEDWPPNLKKRMKKLEFDYGDGKDYLSIVKEDNYENFRKIDSKIETPKLFDIGVINDALLATTRKLGELLNSSPSSVLVKNEDLVVEEVDHDVRNHSEVKSFVVSGNLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQL7</accession>
    <name>A0A194RQL7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase member I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQL7"/>
    <dbReference type="KEGG" id="pmac:106713926"/>
    <dbReference type="InParanoid" id="A0A194RQL7"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265384" evidence="5">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="356" mass="39477" checksum="AD3153F81B9E85C9" modified="2016-10-05" version="1">MHRHTALFTLLAILSPLQVTAQGVRRSESDLTFAELLYVRLSSACRALVDLQFNSMSSQDDIVKTMKITHLDNTMRKTFAIDRAYQTLTQPAMFDITKQTKIIIHGFRDSSQSSVSQDLADAYNDKQIFNVLLVDAEEMMNKGYVLSVHNARLVGKRLANLLANLETFGANAEDFHLLGISLGAHIAGWTGKYFRQYKSRSIGRITGLDPAGPCFSYTYADQRLDKTDALYVDVVHSNRLIQGVIEPLGHADFYINGGGPVQPGCMVPSCSHLRAATVYAESIKTPKSFVGIRCKSWQHFEQNTCEKDLAVLGYGSSIKSRGLYYLRTSGSSPFGLGMEGTKNKKPPVDSWLMALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQQ3</accession>
    <name>A0A194RQQ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_06500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQQ3"/>
    <dbReference type="STRING" id="76193.A0A194RQQ3"/>
    <dbReference type="InParanoid" id="A0A194RQQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000064">
        <property type="entry name" value="BR serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="137"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="43111" checksum="5F3956ACA7D27DF1" modified="2016-10-05" version="1">MRGFFFSMRGRLPLPTPPTEPQLMVASIHSISPLCILRSFDWEGLVHENLLLAPGPFRLFPLSEGSCRPFDDDGCHFLMGFRSNGCSEGAARVQRGRAVARRYGRHGETAGAAPRALSMEGGSAAAAAEAYQYVGPFRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINREKLSESVLMKVEREIAIMKLIEHPHVLGLSDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARRFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIKIADFGMASLQPAGSLLETSCGSPHYACPEVIRGEKYDGRRADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHVPHFVPPDCQQLLRGMIEVNPDKRITVTRVTHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQW9</accession>
    <name>A0A194RQW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside diphosphate-linked moiety X motif 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQW9"/>
    <dbReference type="FunCoup" id="A0A194RQW9">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQW9"/>
    <dbReference type="KEGG" id="pmac:106713793"/>
    <dbReference type="InParanoid" id="A0A194RQW9"/>
    <dbReference type="OrthoDB" id="10005910at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044716">
        <property type="term" value="F:8-oxo-GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04671">
        <property type="entry name" value="NUDIX_8DGDPP_Nudt18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042970">
        <property type="entry name" value="NUDT18_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="333" mass="37033" checksum="677B8BBB4BE61D4E" modified="2016-10-05" version="1">MSRQVDSNIALLLDGLGLEGEENDFCDFTIADQNSVAEAQGITPTTPSNFKPVLGKNVTYVVACVILNEHNDLLMMQEAKESCAGKWYLPAGRMEKGETIVQAACREVLEETGLECDPKTLLTVETAGGSWFRFVLTADIVGGELKTPAKADKESLQAKWISNLQEISLRSNDILHLIDKAKLQKQSKPGQTWHQNILPALTPHSKNLMRLIVVIKKRSTNRMHVLLSEKTSIHFPTCEINPAKSVHSTLRRFMVEMFGADVGQHRPLGLLNLEADPSADGCCISLLVVFRAPLEEVPIIGKCAWHEIPREFENKFLPMITTKNSTIELHVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQX9</accession>
    <name>A0A194RQX9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQX9"/>
    <dbReference type="InParanoid" id="A0A194RQX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="19432" checksum="C6A895E8D592AC12" modified="2016-10-05" version="1">MSSTSLQLNNQIKICVLKSNLEEIGNELIIQNSTIPALDDENECKYRETMGVVQVLRAITTEIELQKEESSKLTAKRRQLQLNCEEMTKSINKALETRNENENQLQQVENEIELKMYDEVEMKKQLEMVNDNLIKITTEEAKQQNVVKVLEKELSSIVPDLPDNILAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRF2</accession>
    <name>A0A194RRF2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRF2"/>
    <dbReference type="InParanoid" id="A0A194RRF2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265394" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="15975" checksum="06431CFE999B1376" modified="2016-10-05" version="1">MDYRIVALLLVMMSSALGEPRPGLSWPDCPCPKIMHPNNAPSVQPLSQSTLEKMYNFEEIILIYKLCLDYGQDLAVTDLVARRSSSASMRPRCARRAADFCSSLRTSTSFSLEYRFSINDATSLSWNDDRKLVIYLKEAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC08</accession>
    <name>A0A0N0PC08_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_03059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC08"/>
    <dbReference type="FunCoup" id="A0A0N0PC08">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC08"/>
    <dbReference type="KEGG" id="pmac:106713350"/>
    <dbReference type="InParanoid" id="A0A0N0PC08"/>
    <dbReference type="OMA" id="PTEMTGD"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17086">
        <property type="entry name" value="RAWUL_RING1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16739">
        <property type="entry name" value="RING-HC_RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000219">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000100">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042741">
        <property type="entry name" value="RING1_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="376" mass="41818" checksum="C8A720E90DEECE20" modified="2015-12-09" version="1">MSSTEPSQNKTWELSLYELHRTPQEVITDATEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDLLISKIYPSRDEYEAHQERVLAKLNMSHSQASLVNSITEGIKLQSQNRPQRSRKNQEESSNPSNSNGTSEPAQNGNSSSVPKDGTSAGNPTPPGQSTSNPASVRSTPSPVPSNVSSVSKNTSTTKRAKSVLTSERSEESESSDGRTEGENSMDTEGEGEPLNPNEIELVFKPHPTEMTGDNQLMRALRDSSVRYLKTTANASVDHLSKYLAMRLTLDLDAELPEAYRLLNFCIYVAPSPGQFVPLAGSQTLRQINDKFWKVNKPLEMYYSWKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCL0</accession>
    <name>A0A0N0PCL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460648">
        <property type="protein sequence ID" value="KPJ13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCL0"/>
    <dbReference type="InParanoid" id="A0A0N0PCL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="17081" checksum="A098FEA3A0A6BB52" modified="2015-12-09" version="1">MNLHTLYNTHICEICSKVFTIKKKYEIHKLSHSGIKLYTCELCDKKFTAKHSLKMHQNIHEGSKPFQCTLCGIRFSKKSSLDRHTYIHTGMKPYTCVVCDKSFIQKIQYTNHVKTHSGNRPYLCQECGKSFSRKDSLNVHIKSHSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCQ6</accession>
    <name>A0A0N0PCQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CD80-like immunoglobulin C2-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCQ6"/>
    <dbReference type="STRING" id="76193.A0A0N0PCQ6"/>
    <dbReference type="InParanoid" id="A0A0N0PCQ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF17">
        <property type="entry name" value="BEAT VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CD80-like immunoglobulin C2-set" evidence="3">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="24910" checksum="9D84D5420A92CD2A" modified="2015-12-09" version="1">MPPTMVFPLPGASVDLAQSDHQQVRIVNMNRRLSGDYQCEVSADAPLFHTDIRSAPLTVVDPPFRAPRLLVSRLSYARNDLLQANCSVDEAYPAPNITWTIDGHKIAETISWQSPEQDFKERGAFSQLEVSIVESLQYRGGQAGYAGHTGDGEHFAHRTESEPDKRGILRYTLSVPVSGQFALGCVATIYDVYARGSEQAHIREDSPRPASVTGEDSSGNIFSDECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE12</accession>
    <name>A0A0N0PE12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE12"/>
    <dbReference type="InParanoid" id="A0A0N0PE12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857251" evidence="2">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="17696" checksum="B794322924D6DB6C" modified="2015-12-09" version="1">MARNLWLLVFSVCILNQQINSFVLHPAERPSESIDEHNLKEEIFVLSVFIAVLLESTILEACKQPSLNNLNDEGFRRKINRDIQVQNYADIITNAIFAHVLRKFSYIISVPRALGMAAILNFLQLVAGFFAFILDNNYMAYILPNLWGIITGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE80</accession>
    <name>A0A0N0PE80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Doublecortin-like and CAM kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_04643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE80"/>
    <dbReference type="FunCoup" id="A0A0N0PE80">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PE80"/>
    <dbReference type="KEGG" id="pmac:106720419"/>
    <dbReference type="InParanoid" id="A0A0N0PE80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="11">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="11">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="315"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="592" mass="64990" checksum="7C5361019CAD2CDC" modified="2015-12-09" version="1">MENNLSRSGSRSSSVCELEKDLSDMKIIKSRTNPRNTVGSARKAKRIRFFRNGDKFYSGVTIPVLPERYRSFDSLTADLTRALVDNVTLPSGVRTIYSLEGRKIGKLDDLEDGQSYVCSGFGEPFKRLDYEASAVTPQSFRLSGPESLNDSASPSPARANNRPSRYLLTNGSNNTTGNGTARVSPAGDNVVRPRIVTIIRNGVKPRKVCRLLLNKRNSPTLEHALAAITECIKLDTGCVRKVFTQSGTAVSALHHFFEDEDVFFAYGNERSGPKPRMPVKASGAAAAAAGVGGAESRDTEPAAAQLLPHPLSLKYSVGKIIGDGNFAVVRICRDKNTGKEYALKIIDKAKCKGKEHYVEAEVRVMRKLCHPRIVSLIEQQDCPEWLFLVMELVGGGDLFDSIAAVCKFSEPQARLLIGHLTSAIAYLHSLYIVHRDIKPENLLVEVGGDGSIRGLKLADFGLAVEVHRPLHAVCGTPTYVAPEILLETGYGLKIDVWAAGVILYILLCGFPPFSSPDGDQEKLFDAILSARLEFPAPHWERVSAGAIDLVANMLRPQPDLRFAAEDVLDHAWMSDDYDESCDFRTWYDDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEG7</accession>
    <name>A0A0N0PEG7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Catenin alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ19758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:adherens junction"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cadherin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
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        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="286" mass="32372" checksum="69EE4B4948E9B9DE" modified="2015-12-09" version="1">MSKFAVRVDAAVSALGSGAGAGLDENDFIDASRLVYDGVREIRRAVLMNRDDEDLDPEDVELDEHYTLETRSKSSAHTGEHGVDEYPDISGITNAREAMRKMTEEDKRKILQQVELFRREKMTFDNEVAKWDDAGNDIIMLAKHMCMIMLEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYTRQGTIARSYSETTELLSVKWIPISKDALNYLEIDKELTLKKRPKQTQMAFWDLYYKINKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF36</accession>
    <name>A0A0N0PF36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein transport protein Sec16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PF36"/>
    <dbReference type="InParanoid" id="A0A0N0PF36"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
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            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1522" mass="171380" checksum="4AC5C988693915C9" modified="2015-12-09" version="1">MSWMKRPQGGALPPNTDQSQYGAPQPYGNQQNMYPNYQGTSSNIAQHQQQQYWQQQQQQQAQPPYNQQYGQMYQQPSYANNANQYYQQPTQYNQNFSNQNYNSTQQAYPQNYYPNQSMAQQSYPQNNVNNDGWEDNWDWGWEDSSKQKPVTNQIAQQLNTSQAQVCSTNANVIEESFASTNTWNWTMEEKKEILEQSSTSTRENKDLPQQPSDNKPQLSSQNVSNTQGNLTSPSQPEHSSSEVKTLSDKDIVKERLPNLALGKRFHLENLTPQWSIESQMSQESSDGPHTHSEGTYRSENQSRNSNKSSPGLNTDNSNFNYTQSHIDEMYPQSTEWSHHSNEDSAKIDSHKNNSSRRQSHDELSSSLQDMSISNTDNVVSDAPAPDNDLEQTLHDSLPPPLQPPPSTSPADLAQPHPDLHSSLSSSMPPPPPVSASTNQPAPMAAGTLPPPTSFPPPSASQNPFKHAGPFSHKNISKNHANVPPQPFPPQMANTNLTSPSVVSKISHSNRMPVGFGANLETTPDNSERPDQPQTASFVPLPVSQQIPDNMEVAPQHDRNEYLQTEHLSSVDFGENTDFSQNVPPPGLRRMVVGQQETEYSQNLNISGDEPPPGLARMVPGQQTESDGYNQSNDNYMERHVDGQITDNSGRPFRQADGQQTLDNYSQPPPNRGSDRRPIGLDRMVPGEPSSNEYMQYQAGNYGGSNEPRVVTGVDHDYPLHVEAGPPEVREQNVDGSDYTEPAVRNPPRNVIGLREATNDSSVDFVSAPGEQQRERELTMEGENLQDLSVISGAEMTFSREQMFDVVSGNVTDLANDASESVEYPANGSRRQSVNRVNTSGEDSERDRTFKSSPRRDREKQKSSRDRDRDRERDKDGRYSRGDRKYDRDPDRRSGRDGRRSEKDRRDREGKGRDRLERDGSPEAPRQRRSARARRYDTEDTDYYSDRERERRRYREGSYTSKPPRPDDKERRRYNTTERDRYDDDGGSRRRADRHRDRTDRSDRADRSDRMDRSDRTDRSDRADRSDRADRSDRMDRTDRRYRDIDPTRKYGNLRREEEQRRRGETYSSPSRAGSREATATDEEPPAVERRRRDRDRRWRTDRSERGDRADRGDRADRDRETDPYYLGGYGAYGSGYGDPFLLQRQQYSYYERLRRTDPAAYMRLYKQLMAAPHAPHTAYADVAGYGSLGYEARGEERGSVHSGRSSAAGLKPTDTCAHEVASLVRIGRGEGGVRAGRGGRVVRRAWCLRRYYGCRAEGGSLRDAPSLRTDLSDRDLNTDASLNLQLEESTVRSERMTPFKYSTAHVKGTLSARHVVLVRAAYPADGRPATVQLVPLGVATARLPDRAHLLAYPGPLLRGVTHKKSVIEYCLSRAAEAAAGGGACDPLGQLLVWELLALLLRQNGVVVGSDIAELLMKNVREHEFALSPRLESRAGSSAERERVVSPERHVRPDQTLTPSPGAVGAVGAAGEVGAEGEEKVGEGAEKPAATEAEALARLRDLLIYGNRQEALGECRHTSEWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I574</accession>
    <name>A0A0N1I574_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLD domain-containing protein KIAA1609-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461113">
        <property type="protein sequence ID" value="KPJ08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I574"/>
    <dbReference type="STRING" id="76193.A0A0N1I574"/>
    <dbReference type="InParanoid" id="A0A0N1I574"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="14174" checksum="767CC25852BDCE69" modified="2015-12-09" version="1">MRIYPATNYNDHYQYINHHTKTLPNGLLMGGQFHFGGIWVNADPFGEGSSAESCSTYRGYRRLSKDPTFHIRSLEVWGVGDKPLTEKEQEERDVSVLDTNPEAKAILDMAGRTRHSEGIREPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6K2</accession>
    <name>A0A0N1I6K2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin heavy chain, non-muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6K2"/>
    <dbReference type="STRING" id="76193.A0A0N1I6K2"/>
    <dbReference type="InParanoid" id="A0A0N1I6K2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="840"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="931" mass="105182" checksum="43271CDCBD067C66" modified="2015-12-09" version="1">MPAVKVFSIFGGQKPTEKHTAPTAQNRAMQKLYRTFSVGPENTNDLKGGKVTAIAACIEKRIVSEPQVKNNSDTVQNNSNITDIKVHSSANKLDVSKRQRVYENVNVVNVDIKTDVKDKLLEESKGYTSVYENITVVNIQQKDKIESDRKAESKLNKALESFDKILSEFSSSTSLSDINSNSAFIVPKLQKSKTCSIIESRCILKKSNSDPESDTKLRKKVSRNKSIDKTTSLWNLDDMKGKELSSPIMPLSSIHNDKINSDKYATYKISSKTTPRTNCIKTEDLKKLDVKTRILKKTLSNPPSTPVPVVTKTKQSPKKLSDPKKIRSKILPDKTKTSVDSKDLPKSQMQKAKSVWEIGNESMISTKLERTKSTTSIAGSPSKIPVIRSQMSQNKFSSTRALFSPTPVDLNNVDQARECAQKNKATTARKSLEKFEPKQIKQKSQLNLKTDSKRQCDKTKKEIVDKKLTSSPKSSIRDYSDEINAMRAKFQQKKINNKRDLVVVLPETKRNENEPEAIETLSPVKYIVKKLEYKTAMESKADAAQFLSCKVIPAIHKEECVANTTFHNHLSTLVGRQVKYIEPRDDTKTCSQIEKIDLHKHAMEKISDTHSDCSDDSGHVSNDAGNDNDTVFDNMHDLNGSVDEVDCKIFDGPKQFGIDVPEHAKSVCPVRPARRGGGGRTNEVDSGTPADAPKVDEQIMFRGGVVGGLDARRDAALARVLVRLQARARGLLARRRAQRLRTQHTAARCVQRNVRAFLAVRDWPWWRLLVRVTPLLAVHRTEHRLKQAQVLFYTLLSVARDYVGAELKKICVQRNVRAFLAVRDWPWWRLLVRVTPLLAVHRTEHRLKQAQEELETLRAKLDKTEGERTHYKGETEKLENKACVMFGIYLFADVSMRYCIKRIGRLNDRLFISHRQQTAAAGWERQNGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7G7</accession>
    <name>A0A0N1I7G7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase FKBP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460596">
        <property type="protein sequence ID" value="KPJ13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7G7"/>
    <dbReference type="STRING" id="76193.A0A0N1I7G7"/>
    <dbReference type="InParanoid" id="A0A0N1I7G7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042282">
        <property type="entry name" value="FKBP6/shu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674:SF1">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="543"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="634" mass="73473" checksum="DBE5A432C17068B6" modified="2015-12-09" version="1">MEDVLKEPIQLSKGINLKELFTSETEFHIDTDFKKKRPDSLLNMNNDLILDTDEDDSDAEDILKNIESSTEQMMLSSPEYHSFKDLAAKMIDCVPTGDVKMLIIEEGDGPLVPVDAEVTLHYAAYWEKAIIPFDSTLTMNSGMPLVSYTFRIRQRVARFRNRSDSSRGPKARFHLLLQPKVAWGEKGAPPRVKPEPALFVIVLYNVRDTQAGSRFNDLPMEEQKKFEVTIRTVKSLHAQAKELFNKRKYKKAIQNYQQSLSVLRISQPNNESEENEVKKLKIVVFVNLAVCYYKIDKPKYVINMCENLDQIIDIESHCKALFYYGRAYEMLGKREEALKYYNKALKLEPKNKEIGKALVDFERFVQESSKKEKEMWQNAFKATPQKKTDVVYDVDEDFQNGVREMCQNLVENEGYAQFELPTGLTRNELDFLKALVTEFDGLVVDEEGEGKRKKNYQPPPPPPQQQYQQQPPQQQFQQPQQMQQQHYQQQVPVQQIPVQVSPQQGHAHHGDPQLLNPANIAQERDHIKEHMDVPIDTSKMSEQELQFHYFKMHDADNNDKLDGCELIKSLIHWHEQGHKQQPQAGSPPVGEKIFNDDELTNLIDPILNMDDHNRDGFIDYPEFVRAQQKSQNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8N4</accession>
    <name>A0A0N1I8N4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="13">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="5 13">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="5 13"/>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8N4"/>
    <dbReference type="FunCoup" id="A0A0N1I8N4">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8N4"/>
    <dbReference type="InParanoid" id="A0A0N1I8N4"/>
    <dbReference type="UniPathway" id="UPA00781"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="161"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="193"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="327"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="600" mass="67210" checksum="65F6933F39988AF7" modified="2015-12-09" version="1">MPEDTKLINKNISTATKSDTMNSLIDKNNTKSVSDSETTIKVKSVIPRKRQELLKWYGWGYKDSMFKLEDGNAIFTGNRYSLGGKTLPYCIEWVNENFNVDITKPPKIPVLPDSFTRSRLPDNIKEELEKIALVSVDGLDRLIRAHGQTLKDISLLRSNSFKRIPDAVIWPESHEQVVQIVQCASRHRFVIIPFGGGTSVSGAITCPEDEPRPIVVLDTSDMNSILWMDKEQLLARVQAGIVGQDLEREMRARGFTVGHEPDSYEFSTLGGWVATRASGMKKNTYGNIEELVVQTKVVTPAGVIERSCRVPRISCGPDWEHVVMGSEGCLGVVTEVTLKIRPLPPVVRYGSLVFPHWEAGFKFEREVARQRLQPSSIRLMDNEQGFDPHKLCVVTLLMEGSSEQVADREKKLNAIAALFGGIPGGANNGEVGYTLTFVIAYIRDLALEYDIVAESFETSVSWDRALSLCANTKRRVRDECARRHIDRYLISCRLTQTYDAGCCIYFYFAFNSAGCTDAVATYEEIEDAARDEILANGVITISHHHGIGKLRKKWYEQTVSSAGRRLLLAAKQALDPDNIFALGNMAFDEYTNEHEIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBG2</accession>
    <name>A0A0N1IBG2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBG2"/>
    <dbReference type="FunCoup" id="A0A0N1IBG2">
        <property type="interactions" value="1683"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBG2"/>
    <dbReference type="KEGG" id="pmac:106719028"/>
    <dbReference type="InParanoid" id="A0A0N1IBG2"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="20689" checksum="2A8F58D405ABF529" modified="2015-12-09" version="1">MERRPRISPNILITGTPGVGKSTICKILSERTKYTWREVSKLAEEFNCLDEYDPEYHCPVLNDDKMLDIMESMMEKGGNIVDYHGSEFFPERWFDGVFVIRTNNTILYDRLVARGYSGKKLEDNIQCEIFEVLLEEAQNSYKPEIVKELQNDTQEQLLANVENIIEWIEKWKEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC43</accession>
    <name>A0A0N1IC43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable ATP-dependent RNA helicase kurz</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01009273">
        <property type="protein sequence ID" value="KPJ20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC43"/>
    <dbReference type="STRING" id="76193.A0A0N1IC43"/>
    <dbReference type="InParanoid" id="A0A0N1IC43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="15998" checksum="C918774413368AE8" modified="2015-12-09" version="1" fragment="single">VMNGKADCWPATGQTLLLGDPGVLLRAVGAAEYAHFNGEEDLFCAKHGLREKAIKEIRKLRKQLTSEINLSVSGVDVTIDPDMKPPDAAEARLLRQLVLSGLGDQVGKKIALDEVKEGGKKSKQSPEFAEIARLPIDIRKCRCVAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICC8</accession>
    <name>A0A0N1ICC8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_01963</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="KQ459910">
        <property type="protein sequence ID" value="KPJ19329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICC8"/>
    <dbReference type="FunCoup" id="A0A0N1ICC8">
        <property type="interactions" value="967"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICC8"/>
    <dbReference type="InParanoid" id="A0A0N1ICC8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="34"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="454"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="566"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="673"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ19329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118772" checksum="8E648FEFB9C6C424" modified="2015-12-09" version="1">MSQKKVLQKPSLSYTSHPDYRRPPKIANPYLQCLGTPHIDSFNYMLQEGLKTALADLIPAEFELPSGEKIKITIDEAAFAKPSVPMDVVGVKTQRVLPTECRQRAATYKGDFKIRMTFNVDNKSITIDRSLGSLPVMLKSKICYLSDMSPEELVQHNEHADEWGGYFVIKGHERLARMLLVTRRNYPVAIKRSGWRMRGNLFSDYGVLVRCVTADQTSTNNVLHFLQNGTCKLMFSHRKMMYYAPVLLIMKCLVDFPDHYIYRLLLHGKKDDLYYVNCMQNILRELHEEGLHNSEECRAYLGKMFRPKLSELPPWASDMEAADFLLKRCVLIHLSDYKSKFYALVYMIQKLYDVVQNKCKVEGADSVMVQELQVGGHLYLQVLKERLQMLLYVIKANILKRVKSPKKFVWSTNEIQNIVKMAGTLEQRMETFLATGNAPSNNVTLAQYKGLTIVAENINRMRYMSHFKAIHRGSFFMEMRTTEARQLLPDAWGFVCPVHTPDGAPCGLLNHLTVSAQVTQHPDPKLLNSLPFVLEKCGMQPISSVSQTPLSQDVYKYPVFIDGRLVGYFSEDTVDRSTAYLRTLKIKGEEMPITTEIVVIPKKEICSQYAGVFLFTTEARMMRPVINLSSGQLELIGTMEQVYLDIAVTQQEIYKGRTTHLELSKSAFMSNLAQLVPMPDCNQSPRNMYQCQMGKQTMGTPIHTWGTNAETKLYRLQTPATPLFRPTHYDNIGLDDYPCGTNAIVAVISYTGYDMEDAMIINKSAYERGFAAGFVYKSDFVELKHSSSYFWRDPARPELATHIDEDGLPAVGARVQPEDPLFYDGEKSQFVVSKYHGKEEVVVDSVRLCGDFSARAPRKACIMLRIQRNPTVGDKFASRAGQKGICSQLWPAEDLPFSESGLIPDILFNPHGFPSRMTIAMMIECMAGKAASLHGHVHDATPFRFNEQDTAIEHFGRLLSAAGYQHHGTERLYSGVDGREMQADIFFGVIHYQRLRHMVSDKWQVRTTGAVDTLTRQPVKGRRRGGGVRLGEMERDALISHGAAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID78</accession>
    <name>A0A0N1ID78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01065507">
        <property type="protein sequence ID" value="KPJ21668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID78"/>
    <dbReference type="InParanoid" id="A0A0N1ID78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="8066" checksum="CD94DC1103646D97" modified="2015-12-09" version="1">MGWPHCPQNERPMGQKIPRVKLANKQHNKLSSWQPRTGRRSVDRPPARWTDGLVKVVGVHCMRAAQDWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE19</accession>
    <name>A0A0N1IE19_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM89 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE19"/>
    <dbReference type="STRING" id="76193.A0A0N1IE19"/>
    <dbReference type="InParanoid" id="A0A0N1IE19"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949:SF1">
        <property type="entry name" value="AT07979P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949">
        <property type="entry name" value="LEUCINE REPEAT ADAPTER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="677" mass="74583" checksum="733CE4F4724E5686" modified="2015-12-09" version="1">MLMVHTNAQPMKTNKIKGPPPVPPRPSQSLVAEALAKTRKAVTESKSSLSKSRASSKQDLNNAKKAKTLDRTYAASQQIVSPKQNGLARVKSFIRDVISDRSSSSDEKKSSGQNSRRSSSDSNCIQGPTSVKRSNESLNSKAVKTCRQILVRSLSTSNKLDQDSKSKVSKSSSFAEKTLPLRKAPPPPLSPKPKLKPMKPLPVNKAAPNQHKQKKELTEVSPYSLPIDAKAESNIVPEAPYATVDEVQEFDDRLRNSPSRQNNSLDTQNIYNDSSVEDSNKNNNSLERKTSRVTEMLISEILASRNNNTDEANTVIDKGKDSSILCNGNDSPEITKDMNNHEMLIYELQTMRSQSNVPEALEVDPSEQCESDLEPNYALCSVTSEQTDDMYEQAYAYIADDDLKSRLRKQFRAISTMSLSGLPPLPKSLSGFADAEPDMCESPTHSEDPPPQDLDSQLTYLKKEMSIIDAIVPRKAPHIAFGIEDHTSHIAMGQRSICTDFQQAINIPASGTLGLALNSNQSQTRGLLVLSGRSAGAIAFNKTKHNKQRLSSGIEVSKSVCCGNVPLSRPACPLYHLGHLPFKAVEYRIGTKDRYSTQNWLVPDVTGVRSANCAHISPSGDPHRPHIPNASLRQLDLCLLSELWSLSEAMAAWRRQLERAPRLRPAPPPPPPHYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEH6</accession>
    <name>A0A0N1IEH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01042860">
        <property type="protein sequence ID" value="KPJ21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEH6"/>
    <dbReference type="STRING" id="76193.A0A0N1IEH6"/>
    <dbReference type="InParanoid" id="A0A0N1IEH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12001" checksum="44865A1F31CBAABE" modified="2015-12-09" version="1">MIALIDESGNIILQSGNSVVGKVHVGGVLARLLDSPYTKRAAHPLALPVLQSPFPRRSSLLPSRSDCAFDDSALHLLSPVPHSSVSRIEHKESLGKDFVYTNLIITFYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGW9</accession>
    <name>A0A0N1IGW9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit CCDC47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGW9"/>
    <dbReference type="FunCoup" id="A0A0N1IGW9">
        <property type="interactions" value="1883"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGW9"/>
    <dbReference type="InParanoid" id="A0A0N1IGW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873949" description="PAT complex subunit CCDC47" evidence="9">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="49876" checksum="500901D7F4F1A058" modified="2015-12-09" version="1">MRLVLLSIALLLCSVYVKAFEDPTLEDDDFAEFEQFDADDDATVADFSEDEKEVPVEKKAPTKDKFSQQRDVEDDMLVEDEDNEFEHFQDPEEFEGFQDSVPRSSEQPKITISKVPISVRRRWDAYWLEGILCCALAAYAMAYVIGRAKNTSIALNFLKLHKPLLEDNFTLVGETGADVACAEGERGWRREAEHCFTMWCSGRVCCEGMLLTLKLIKVTIVFLRETGADVACAEGERGWRREAEHCFTMWCSGRVCCEGMLLTLKLIKATAGVLDSRLCGAITQYQKHVQYIHISDRYCGPKLMEDTAMTKPPETERVLLASFALSPGGGGDEVRPLLQLVFYLLEKLKRLRLSKEALAKCEKRRQKVAEAWLRGAHAARQEQAAQRREEKRKQEKERILAEDDPEKQRRWELKEQKRQQKRKAPKLKQLKVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH02</accession>
    <name>A0A0N1IH02_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multivesicular body subunit 12A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ESCRT-I complex subunit MVB12A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein FAM125A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_02539</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MVB12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH02"/>
    <dbReference type="FunCoup" id="A0A0N1IH02">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IH02"/>
    <dbReference type="InParanoid" id="A0A0N1IH02"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032510">
        <property type="term" value="P:endosome to lysosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032801">
        <property type="term" value="P:receptor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019075">
        <property type="term" value="P:virus maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040335">
        <property type="entry name" value="MVB12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018798">
        <property type="entry name" value="MVB12A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31612">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31612:SF2">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10240">
        <property type="entry name" value="DUF2464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MABP" evidence="15">
        <location>
            <begin position="15"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="UMA" evidence="14">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="41351" checksum="1BD30CA4D270C334" modified="2015-12-09" version="1">MSKVLSALGGALPDERPLLSLQIVESVAKCPTGYWPVSRTYDEDADAGLLRQNGLFGKKPSHYICLSKSEGNTICIIPVNATAIANTNVSEYGSKLSLLSWQFVVLGVPGYVMDGVLVVGEREAAPAGYSVAGRAGKRRLCTRVSRHAATHHAHHAPPVTDVIVCSKMRQAPRGFLLAGEMNGKMVCYKVCGGSADTSPTGAPNDYENVVTNLTPDANRRLRPAPERPPKLSPLINELNNLNLKSPNANVDELKTDHDYEALSPSYNVKPSRPAPIQPPIPPPIQPPRAMSPQQASRAKSPVGSPGPTSPAAVGRRKGPAPLPRTSNYQTLGGYNGMEGVPFVLNPKLRGLPSDALTQLPVIKKRPRFELDRDYSYSFAVERQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH91</accession>
    <name>A0A0N1IH91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterogeneous nuclear ribonucleoprotein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460622">
        <property type="protein sequence ID" value="KPJ13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH91"/>
    <dbReference type="FunCoup" id="A0A0N1IH91">
        <property type="interactions" value="1790"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IH91"/>
    <dbReference type="InParanoid" id="A0A0N1IH91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000531">
        <property type="entry name" value="Myelin expression factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="453"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="508" mass="55656" checksum="5DE752DE2A548F92" modified="2015-12-09" version="1">MDNQKEKERDRSRRGDRPSRFSDVERDRSNDRERTEGKRLFVSNIPYEYRWTDLKDLFKEKVGDVAFVELFTDDHGKPRGCGVVTFSTSEAAKKALSVMHRYELFGRKLVLKEEMGNSDRSRNNTRSGGGNSRNARDEKDNWGPSKPRESENYNTYGLSLQFLDSINVQPPLVKKVFVANLDYKADRAKIKEVFKMAGKVYNIDLAVDKDGNSRGFAVIEYDHPVEAVQAISMFDKQMLYDRRMTVRMDRGTSDKNELKLPEGLKGIGLGLGPNGEPLRDVARNLPQGQNTTNIGLSGANTAIGGGVLGAVPTAGVALNGLGTGLPATTLGTNAALGGGLSLQALGLTGLGALQNQLLQQGLTANDLATVLSAQANVNTNNLAMNSTDMTPNMMPNTNLNSNVIGNTGLSSGPLSGFGPVPGPNRQMVNTSVQSQNYVRDTRPEQSSRDKISDMVIITNLPPTVTWQLIREKFSECGDVKFAEMTASDTAVVRFHKEWDAERAISILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHQ9</accession>
    <name>A0A0N1IHQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trypsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHQ9"/>
    <dbReference type="FunCoup" id="A0A0N1IHQ9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IHQ9"/>
    <dbReference type="InParanoid" id="A0A0N1IHQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874066" evidence="8">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="29478" checksum="D2520C4B7EF92399" modified="2015-12-09" version="1">MYKLIYIFLTFVTLVFCEQNVTEYKGLLTSDCTKAYFRMYVTRRVPPRNYFYVHETLDPEQLLVSGNTANTNNTDVDVNRETFILAGSTQRSRAQKYRICAHFIHPLWNATAGVSHDYDYQLVLLETPVPVTPSSRPIAIGSLEDIRPGNMVAISGWGHLQFKKSRMQDLVRRVYVPVMADDECRALPHGYFRNITPRMFCAGYLDGAKDSCQGDSGGPAVINGKLIGIVSFGVSCAAPRQPGVYSKVPAVRDWIRAVTALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II37</accession>
    <name>A0A0N1II37_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="12">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04521</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II37"/>
    <dbReference type="FunCoup" id="A0A0N1II37">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1II37"/>
    <dbReference type="InParanoid" id="A0A0N1II37"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="839" mass="92544" checksum="8C159DA55BEC5388" modified="2015-12-09" version="1">MKSSPTRKYENFSNDHQGKDTDKYSLDSQDTASLHSEEGGRHGPDVSAGAGDMWISAVESSILAWEEVADRLHVDVRRGLSWREANDRMNFVGPNEFQVKEEDPLWKKYIEQFQNPLILLLLGSAVVSVCMRQFDDAISITVAIIIVGIVVSTGERSEFGDIFRMMQAEEAPKTPLQKSMDTLGAQLSLYSFCIIGFIMVAGWLQGKAIQDMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNAIVKKLPTVETLGCVNVICSDKTGTLTKNEMTVTMLSTSGGHLAEVSGAGYNSRGELSLRAYKGRDLDVARMAVQTLLEVGVLCNNAEIRDETLYGQPTEGALLAAAMKNDSHHVRDQYTRLHEIPFSSETKMMVVKCGPKFKDSSVKEEVFVKGAIEKVLPLCTHYIDSAGNYAPMTRDKQNDFLSEAYNIGRTGLRVIALGRGQSMESLMYTGVCGVCDPPRPGVRDAVATLRRAGVEVKMVTGDARPTALAVGRHILFLCILCRLKVGNIYKSMGTSLFRHIHVFYRVTPKHKLSIVKSLQRRGNIVGMTGDGVNDGVALKRADIGIAMGRNGTDVCKEAADMILVDDDFATIICAIEEGKCIFYNIRNFVRFQLSTSIAALSLIALATLMGIPNPLNAMQILWINIIMDGPPAQSLGVEPVDHEVVRRRPRDTTRRIISRGLLLSVLLSAAIIIAGTLWVFNREMSDNKITPRDTTMTFTCFVLFDMFNALSCRTQTKSIFQVGLFSNKMFLVAVFMSLVGQMLVVYFPPLQRVFQTEALTGHDLIFLVCLTSSVFIVSEVKKLIERTIKKRSYGKFSTKAHDAMDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIL6</accession>
    <name>A0A0N1IIL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIL6"/>
    <dbReference type="InParanoid" id="A0A0N1IIL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="6755" checksum="1EFE64EA1BE68972" modified="2015-12-09" version="1">MSLEVAQYAGNEPQERPAEVPWVQFTIPSVTCEDRVEEIYEDLCYVKFTSAMPEVAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIN9</accession>
    <name>A0A0N1IIN9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIN9"/>
    <dbReference type="InParanoid" id="A0A0N1IIN9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="8256" checksum="AA7CB88CBDABF5DB" modified="2015-12-09" version="1">MCFHIFDPNPHPVTSSSRHLATSHPPRRNRVATSLPPPLTRMLWCRHALGYRLSAPKPITTYNIQHNNFALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJC3</accession>
    <name>A0A0N1IJC3_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJC3"/>
    <dbReference type="InParanoid" id="A0A0N1IJC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21188" checksum="838D177CA787DD34" modified="2015-12-09" version="1">MSMGVGEHLGVPAARHPSRRESEFKKPAHAPQNGRVHHRPSYPYNKANDLMFSCTGHPSRRESEFKKPAHAPQNGRVHHRPSYPYNKSESLSSTSAPAHRPPPLRISNGFQPPSSSIDSSQLPIESILKEMKSLPTPLSVIAATPRKELDNKFIFNPYTNKVQENPQLANNDLKTPVTKSAPPALWHNDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJG9</accession>
    <name>A0A0N1IJG9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04658</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJG9"/>
    <dbReference type="FunCoup" id="A0A0N1IJG9">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IJG9"/>
    <dbReference type="InParanoid" id="A0A0N1IJG9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="16">
        <location>
            <begin position="844"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="788"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="400"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118380" checksum="C424C78D4BD3BB61" modified="2015-12-09" version="1">MLEAEEVDVDFFTPVSSTSLSKIFSIDKHIEDKENASLVYVPQPVQNDAQQKHEESKASHIIYASVFYAYEWSNNAYVSKGKTGAAILKNQKTERYNIILYDSNKVTLSCTNISPQLKVVVKENANLSFYDNTGKYWSLYGTEAEISKCIENLKLFGVTIDNSNEDSKSQPEIMKCEENNTLTQNPTDHKESDTDSSINRRTKDSILKRMATMGHSVLPMQSTNYTKSNSSDSDDSAEKVIRYKPQRSIGKTKASEKIDCTDSCTEINWKKTSPISQSPENITVTSYDHRIVPISGSNIINNPILNNSNELNLFMSEQRISNSEIRINMNRMTDKLDKILDNIQGVCNKGNNNIGYENNIIQKLLAEYENKIKLYEDFIMSKGLDCSILKSSQKQENDDLNIHKNKITNLQSIIEKQEKENSRLCNELKSLEEKYKILCKEREEEYDIKMKEVTSLRYELNVKNEELKTQAVEMESNKMQNKDDIKNKLKSIMNRTFHALSANFDLQFENDSLAEAQGDMRESLLTLKSQMQKLIQVTQESLDAQSKEPNKEQNVESNVLGTDSSKNELDDEYALFMQEMSKSGAYSTENNQDSTETSKEDGNKSDIEDELATLLGMKCAVYHTHKWGGQPSLHNAMVSSVEPHQDNDQFSDLQVRVLFTHPTHAEMLPCPFYLDGECKFSDEQCRYSHGALVQLSSLKEAIEPNYETIKPGSRILLKLKPEDGEDISVAKKSTEKYHLWHIAVVKSVDFDTKECVAKLENGVKTGEKRKISADEFHLSFEEIFPLSNDNEDVESDDSLSDTEYPDNKSCRTEPEGAGSGRPELLVEKSLLTNTPAIGEWERYTRGIGSKLLLSMGYVPGCGLGAAGAGRLQPVEARALPAGRTLDHCMQISQAANDPLKVEQKLKRLQKREEERNKRAYEREKERERRNVFNFLNRTLGDSSDKPETSKDTSLTDIKQSTNKDLNIEQFKITQDSKRLELELNKLKNSLNKYPTGSSVSLNIKSQIAEKSRELDNLKSREQNIEKEQRRRKDKKNMTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INX7</accession>
    <name>A0A0N1INX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C16orf73-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460748">
        <property type="protein sequence ID" value="KPJ12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INX7"/>
    <dbReference type="STRING" id="76193.A0A0N1INX7"/>
    <dbReference type="InParanoid" id="A0A0N1INX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="224" mass="24816" checksum="948C39DDBA9FCBF2" modified="2015-12-09" version="1">MPVRAVEIVDNTTPASLYLEMFDTDTIQRAEEWRPLGSVLFIADARVSWRGRGARTQVCGRSVVTHQPHTSDAEALRLYIQDRAAGGEAAAWSEWSGQRACAATVEQVRDRLADGAPFCASLHALLTHLDLDDLINSTDNNCEELRVRFADHTGELTARLPANILQNTLGYTAQQLKAMSSEERAAVRWRLLLEQCCAKLAATPHRLIVLSLRKANPADPIPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP65</accession>
    <name>A0A0N1IP65_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP65"/>
    <dbReference type="KEGG" id="pmac:106713355"/>
    <dbReference type="InParanoid" id="A0A0N1IP65"/>
    <dbReference type="OrthoDB" id="6596404at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="17547" checksum="FD83563AA62BD18E" modified="2015-12-09" version="1">MEKCFVACGCDDQEGVTKGDLDRFTDKIENVLNDEKGRRLFRNFMFTTKMKDGRRTLDFLEHIERLLGYSEDAESTSYRNYLRDFDRLIDEAERIEELDFATMERLAIARDSENKDEMEAALKLLKVEAIKALRREYSAFRRHFIPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB2</accession>
    <name>A0A0N1IPB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metalloprotease zmpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPB2"/>
    <dbReference type="InParanoid" id="A0A0N1IPB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="469" mass="49081" checksum="35F9C39732080C66" modified="2015-12-09" version="1">METTDLLGDFASGDAVPAGEAPPPQALKRDQDSTDDFEHLEREGKRDEFESPSHQHGTARAATQNFLDMERDEFVDTPRAPSVTDKLADHIADKFTDSESEADTAGESPLHRPEPSVHVDSVPTPEVPKQELRAQPEPTPLQAATPAATAAPPPTPTPIVLSSTLPPKPVALPETDIKAKVEPATPAAEPVPKAPSQPAAPKAPSQPAAPVTAAPVPERKPEAVRAPTAHVIEAEVIFCQMGLASGCAWQAASFTLVPAPSARADVSPCSSRLVHPVAPPAPAEARVQYISLVTKLRRDHDTFVEWQGLGPAAGAAVTHQQAAARPRPPAHVPATAMRAFAGARLTHASAMPPAPRTPRSVRPVAGRGRGRLGERDGEHDACALRGRGAERGAASRPSIDATMLGSTLKDCTQKVSGGGVGGGGRRRTRPATVSAPATATTLTDSSPLLVPLTWLVRLRSSAARSKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB9</accession>
    <name>A0A0N1IPB9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPB9"/>
    <dbReference type="FunCoup" id="A0A0N1IPB9">
        <property type="interactions" value="1909"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPB9"/>
    <dbReference type="KEGG" id="pmac:106711255"/>
    <dbReference type="InParanoid" id="A0A0N1IPB9"/>
    <dbReference type="OMA" id="QMRNANA"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFH" evidence="7">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="668" mass="72372" checksum="0D5A49A19D64CEEA" modified="2015-12-09" version="1">MNPSLVIKQGTTTGQSGMQTGMVTVPITVSSSMSNTIPNALTMNKPGQNVVVTTQNLGSGQPTILPNVQILNMRPEAPSVAAQKSVATVSPRVVIGTQQVVGARAVAPGITLQTLQSLQQGQQGHLLLKTDTGQYQLLRVGPAPGGNTLAAPQPQTLRLSTVPAHPGVATVSTSIAAPAQMPTQIQQGPAPVSVSASMQSATPPPQPPTVTTQKPSDNTKEKCRNFLANLLDLSSKEPKSVETNVRNLIQELIDAQVEPEEFCNRLERLLNASPQPCLIGFLKKSLPLLRQSLVTKELVIEGINPPAPHVAFSNIPAPTQQVVSTSNVQMQKPAPKVGGTIAVLQNIPVHTKINVGKVGKTVGVNNKANFPRPGLSSAALSTVITPGQSLLKEKEKRSSMPFTPPHFVDDKMAGDDDINDVAAMGGVNLAEESQRILGSTEMIGTQIRSCKDEFLVPMHLMQARVKATCAKHGLEEPPPEVSALLCHALHERLKTIVEKLAVIAQHRIDLCVKMDNRYEISQDVKSQIKFLEERDRVVKKRCEDTEREMLLRAAKSRSKNEDPEQAKLKAKAKEMQRAELEEVRQREANLTALQAIGPRKKPRLNEGIGGSGDNVSTNTNQTSSGMTGRGQMALRTRIKRINLRDMLFLLEQEKDTARSLLLYRSYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPI8</accession>
    <name>A0A0N1IPI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460470">
        <property type="protein sequence ID" value="KPJ14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPI8"/>
    <dbReference type="InParanoid" id="A0A0N1IPI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="540" mass="60588" checksum="BADF3B81ECD540D7" modified="2015-12-09" version="1">MQNKVTNAGWHADLCHQALVESDLIWFATSASTPVPEENTEAMYVRNNNSTNQRSEGDVEEIKVNKNVVNVGWHVIPCHQTLTESGLVWPASPTLSSAPERENKNVHARGTTNSTHLYYQWSESGVGENKENKNVTNVGRHAYLCRQTLAESSLAWSASSAPLLVPERKNGIRCATDTISSIKWRGKRTEKRVNENGENKKVTKEGWRAYLCHQPQTEGGPLWTASAISFSEPERSTGTKYNRDKASSITEIKRININTIFSSERGKRNIAAIQRKSERSKKTLLKLTGSIIILGICKIMVQILRQKWPSTSAAFLRLIKSPTHKYVYPRPTSKTEMLGALQTAPISGLQRPEGGVKENEENKNVTNEGWHAYPCHQALVEGGHVWPASSTPSSVPEKNNDAMDTTNSINLRGQRPERGVKKNGAHKIVIKEGWRTYRCHQPYTEGGLVWTASFIPFPDPNKFTGIKHNRGKAISINEIKTKNVNTFSSRRGKRNKVVIHRKPEKCKKIILSRYGLSHLEIVKQSCKYCCKNGQVPVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPN1</accession>
    <name>A0A0N1IPN1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.361</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_02801</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60344"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.361"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.361" evidence="3"/>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPN1"/>
    <dbReference type="STRING" id="76193.A0A0N1IPN1"/>
    <dbReference type="InParanoid" id="A0A0N1IPN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140944">
        <property type="term" value="F:histone H4K20 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043516">
        <property type="term" value="P:regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10528">
        <property type="entry name" value="SET_SETD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016858">
        <property type="entry name" value="KMT5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047266">
        <property type="entry name" value="KMT5A-like_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51571">
        <property type="entry name" value="SAM_MT43_PR_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="176"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="311" mass="35228" checksum="7FB4F8EEC10A8188" modified="2015-12-09" version="1">MVEADGAVMTPHRIELCEKELLRPVRSYRSRRILVASPKKTENGDLLTKAPIRKAQVKSKPLKNSNGSNNSTNMTNGTTLRSRSSRTSAKGNDSHKLTEYFKEELKVPKVESPPPLKAINKTAKVETKAVNGHTNNSNHKLTEYFPVRRSVRKTSKCVMAEKMRDLERAVREQREDGLKVEYFDGKGRGVIATRAFLRGQFVVEYAGELVGVAEAREREQRYAQDPEAGCYMYYFRHCDQQYCIDATAESGRLGRLVNHSRNGNLHTKAIWVDGPRLVLIAAQDIAPGDELTYDYGDRSREALRHHPWLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ76</accession>
    <name>A0A0N1IQ76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoribonuclease Dcr-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ76"/>
    <dbReference type="STRING" id="76193.A0A0N1IQ76"/>
    <dbReference type="InParanoid" id="A0A0N1IQ76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="347" mass="40476" checksum="D327A974E075716C" modified="2015-12-09" version="1">MPTRVLARRMVALQACRILHKSGELDNQLMPIGKENFKAVELEGTGNGNGNGIEPIDPNDSARPGTTKRRQYYYKRTACAFTDCQPVVDATDEEIESGEYDASKRHFKPVTAARRRRRRRRTKREYLTFLCISSSYNKREVKQVLCETEMRVFMRFVFSDVLRVRRRGMKLQSEGSTHNNYYIVPTIKTINEDGTSKVDIDWSFLELIFKHTEEKRNLEVEKPIFFQQEEEEVIEEKKVENNGKGKDEKVKKMDNPLLKEGETFTFDPEKYKEAVVTPWYRNQDQPQFFLVAEICWNLTPDSAFPSATHTTFRDYYSTKYGVTLTQPNQPLLDVDHTSARLNLLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ77</accession>
    <name>A0A0N1IQ77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459718">
        <property type="protein sequence ID" value="KPJ20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ77"/>
    <dbReference type="FunCoup" id="A0A0N1IQ77">
        <property type="interactions" value="1524"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ77"/>
    <dbReference type="KEGG" id="pmac:106708778"/>
    <dbReference type="InParanoid" id="A0A0N1IQ77"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="431" mass="48645" checksum="F5E8D46375FACCEF" modified="2015-12-09" version="1">MDIDEIVPSDHQENHNGSSNDYEVTYNSNEHNQYEYPKLFNSKTLLELCYSSSPSLKSKGDVQPYLRGCKWSPDGTCCLSVVNNDGVHVTELPRDLYSGSVDSKRKIDVLDPVIHVKESGLIYDFCWYPGMNSTIPESCCWITTRQNAPIQMWDAFDGSLRCSYRGFNAVDEMEPAISVTFNNEGNRIIGGYKNVLRTFDVERPGRDYAEHKINSPASCFATSGNLLAVGSWNTTISLFNVNEMGNYKSIGKMHGHTGGVTHAKFTPDGLKLVSGSRKDHRLLIWDIRYYRTPLNVLSRAVDTNQRVYFDISPCGKYLVSGGTDGLVKVWDANKVNWHSSLDVTDENKYNVTYIFPLHKDCCNSVSIHPCRPILATGSGQYHFKDPLAITSDEKIDEIEKNQDTKECINDIKYSDEAENSLVFWWTGDIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQS8</accession>
    <name>A0A0N1IQS8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable alpha-ketoglutarate-dependent dioxygenase ABH7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034022">
        <property type="protein sequence ID" value="KPJ21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQS8"/>
    <dbReference type="FunCoup" id="A0A0N1IQS8">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQS8"/>
    <dbReference type="InParanoid" id="A0A0N1IQS8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="28777" checksum="D3D0D7F49FA0F074" modified="2015-12-09" version="1">MYTAHTSCDTRPIVYEAGFFYQLIQLGTYDLLFVIHVSKGPSPDPDYIEVLPSWPEGEAIMRINATSSMRIYPNFVSEEEEASLLAEVEPQLKRLRYEYDHWDNAIEGYRETERDSWNEQNAAILKRVRDTAFQPNAQLLPRAHILDLAAAGYIKPHIDAVRFCGNTIAGLCLLSSAVMRLVHESRPEFQLDALLERRCLYVMRDVSRYEFTHAVLGGEHSMWRGEKLPRRRRIAVICRERPLPEHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFS4</accession>
    <name>A0A0N1PFS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein CG7816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFS4"/>
    <dbReference type="FunCoup" id="A0A0N1PFS4">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFS4"/>
    <dbReference type="InParanoid" id="A0A0N1PFS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="41249" checksum="9456EAD459413C06" modified="2015-12-09" version="1">MAGFVPEYIWNFVEELDEHPWLFAALASILVGLSGILPLLIIPIDETATFKDGAGAATLRILLSFAVGGLLGDVFLHLLPEAWQHDLANTKEGEHVSMKCGLWCLFGMLVFIVVEKLFAAAEAHEEEEEEKPKGPIKQIEIEEIEKLLIAERKSRGKENGGLCGNGTVTAKQLYDTCVFNNNTKGEGGCCSAVTTNGAVKCKGSSRWMGRCLLREAREKAHQLSKEKTEKKDVAGYLNLMANSIDNFTHGLAVGGSFLVGFRVGLLTTFAILVHEIPHEVGDFAILLKSGFSRWEAAKAQLATASAGLIGAMTAVIFSGARNAIEAKTSWIAPFTAGGFLHIALVTVLPDLLREDDKKESAKHLAALLAGIGVMAFMTKYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH01</accession>
    <name>A0A0N1PH01_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460419">
        <property type="protein sequence ID" value="KPJ14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH01"/>
    <dbReference type="InParanoid" id="A0A0N1PH01"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37059" checksum="66026209330DCF63" modified="2015-12-09" version="1">MECLGARAPERGPRLGLSLVTRLAFRFKANITTTTWLALGEEVAEETPATLLLLIGENLPAMRPYRENDCRSRHRLWSIVLWSLKAPLVTNKMNTTMVMQGDRKSNFPREYERWEADGATWIIQDLPPEDDEKFIEILVDHLSTDEVLCSITRLAEHPESVKGISDFWRVCLAERTSIACYKEVDGVRTLAGGNCCVLAKKDDKPSIEIKGDEWKTVYEGLKFPEDKCDPFEYLGEDKLLVGYGLVVQREFRGARLGARILNAREPLCKQLGVKAATTVFTGISSQKLAARCGYKVIAEATVHEMSQAGLKYPKDDQRSIKLMVKRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHB5</accession>
    <name>A0A0N1PHB5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine protease K12H4.7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460423">
        <property type="protein sequence ID" value="KPJ14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHB5"/>
    <dbReference type="InParanoid" id="A0A0N1PHB5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="445" mass="48943" checksum="52A7C5EF880C3403" modified="2015-12-09" version="1">MRYYYNDEFARTNNIVVVLGGPWAISPDWVSGGLPHQLAEKIGAGLFYTEHRYYGKTRPTSGTSVPELRYLTVDQALADLAQFIQHVQSDQFQDGRFRAGQVALAGCGHAGSLATWMRLAYPHLVSAAFSDSGPLLAHDEFSEYLEVVWEVVRAQGGPECVATLDVAMERLVIETLTQEGAERISNMFNTCSPIEASNPLDTSTFFWQGVLEPLARLVQSATSADISRACEVLTDPNVPEPTERLAKWVTSQPWTQPCIQADYTAHLAAHTNTSYDAPHSVDRLWMYQSCVQFGWHRTTASFNSFHSAVALPYFRALCRQYFTDDFDDTLQRAGIERTNLLFGGLTHMPDAVVSVVEGHDPWSPVGPNATHATRMSPVYVVPGGSQCRVIRSTGENETQQVEVVKQAVLLNMQELLSGKPPTHVASAACPSVAIILIIAALALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ75</accession>
    <name>A0A0N1PJ75_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methyltransferase KIAA1456</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1PJ75">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ75"/>
    <dbReference type="InParanoid" id="A0A0N1PJ75"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF37">
        <property type="entry name" value="FIRE DANCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="941"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1247"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1469" mass="162890" checksum="B60CDF5A8D36DC8D" modified="2015-12-09" version="1">MRVEGTRAGSGGSARVSGSPRARLMPFVPVPYTLCCGNGKYLDINPSVFTVGGDRCTRLTAQARQHNNEVVLCDNLCLPFRDESFDAVLSIAVVVLCDNLCLPFRDESFDAVLSIAVVHHFATAERRARALRELARVTRIGGRLLLTVWAMEHEGRNFHSQDVLIPWHRPATLCPPTPTARFLSVDYERNESWKSRDGSPGSSSLSSPNETCYSFVRRALQRLAGRRSFLSSWSLSTRVNQRPCSRPEPPAADLPIELRRLDEALPSRLVAQTSETTTLKSRSLTDIADIERRAMVRSRSSLPSLGGDETEVPLQDQQSVETTETRKKPKLVKQKKSINEDDAEEDLDKPTDMKSMVEEMPNFKIHTPRLQSKKPGVFKQSSLNEELMSTERLREKERLRKNIQKQASLNEEYLYSRPGTLDSIRDSIFSTSATTAKKFQSLKNGLTNKFKTSTTNIDKVTVFVRMLQGWKTHGPVPEVPTPSDSNANSEKSYPERRHSKEDGSDSSKDSSLQSDTSVDSEDSFASVIYVPKADGSGDPLSPTPLSPGPTSPRLKVSSVPTSPRMKSSPGLPSPRMKQSFSLIRPPSSPNSTQSPGAVNKILVAQYSLKNYSTTNTPTTPPLKPQSKSQPNSPPKSESEEKTLPPEPLPPVITRNISIEVFEEPDPIPPIKEEEETPTEVTKELLAEINKDIEEIHKLTADTNDLKPRVVLQDIKPYPKITLQTVAELPEIPQFKPKEPNKSPTSDTLDSRLADRKRKERIRQIKEMLNKGIPPLSVSRRPPFPIVRTNKPEPIAKSHPKLMSLELFNPATDDMDSDSSGVSSPDSVDSVISVIPDELRKTAIEKDLPNPTTTEEKKDNAPNTPEKSNSSSPAQSLIEAATEVAHSLDETCETVIQSSPRTKRKHLDKIENAEAMAIVQGASSSSSSSNWSLNKLSPGDLRILEDRSRSQSHTSSSGSSSSLERLSPGRRSKDRSPKQGSTSNSTWSLNRLSPNRLDGRSLDEKSHRSPTRLPYDSISISSTDSEKSISKSESFNRNIANEPLVTCKSDMLAKEEDWIVEQERNQHLTEFAEKLSEKLLQEIDEYSKRINEDDFDLPSSSSSEKSISLRLKREEEDRNTQKILDELSDSLQHLEEPYANKLSTDMHGLNKMSTNEKRYITSLSDTQESDINKLFPKCGSKTKSKKRSKDVDPIINKYRELKKSMKVTSDEDIYLNNCANVQYHVTKIVADDKLPEVTDTKNPDEDSAISSSNGNPEITIESGTYDTSQSLETGYSLESEISVDSLCTSTDKRSSLKVGQSTDSSDLDKMEISPESVTSRSSASTAPLKSGFSVESSDTSAGSDWSRRDKTGSTASLGCASLNSLPSCSECSREKKLLEKRSSSEDTAMVTAETCRAVTHAPLLPSLSDASDSLPSEGGAVTLHRYYHVFKKGELDQLIEQYVESLHVVSSYYDQASWCVVAEKVQVWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJI9</accession>
    <name>A0A0N1PJI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ommochrome-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460423">
        <property type="protein sequence ID" value="KPJ14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJI9"/>
    <dbReference type="KEGG" id="pmac:106711053"/>
    <dbReference type="InParanoid" id="A0A0N1PJI9"/>
    <dbReference type="OrthoDB" id="7234944at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879817" evidence="1">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="30947" checksum="1954B9FA3DC58C0A" modified="2015-12-09" version="1">MLKLFILCLAAIQTTSSEGCKGILYDGRNYKEELMKADIYKPSSLAIDYKTNALYFTHIEQTGDAFYKTSKINLKDGKFTNLEVNNGFSLDVDQNNHVVYIGGHKGLYKYNEKSKKAHLIVPGINAWNVFYKNVLYYIEFISQTIYTYSNGKSKPYEELEGIKVYYFVIDHEGYIVYSNSSGVFGKKKGEKEVLYKEVKSVDEIREITLDRNGRVFVLSADGIYRVNKVTKSIDKVAEIQDVYGIAFDINNHLIYSKENSLLRLVPNKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKI9</accession>
    <name>A0A0N1PKI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA synthetase family member 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01017204">
        <property type="protein sequence ID" value="KPJ21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKI9"/>
    <dbReference type="STRING" id="76193.A0A0N1PKI9"/>
    <dbReference type="InParanoid" id="A0A0N1PKI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="13243" checksum="6F557B74C216657A" modified="2015-12-09" version="1">MSEVGMALSNPYRPVEQRQVGCVGVPLPGVTARIATVDELKPLVTVESPVPDTKISLDKLGLSGTKEFFTDSEGSEWKQPTVTIHERNQDDEYEGELLLKGPAVFTRYDIKLSPATPSARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLH0</accession>
    <name>A0A194QLH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase II subunit RPB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLH0"/>
    <dbReference type="STRING" id="76193.A0A194QLH0"/>
    <dbReference type="InParanoid" id="A0A194QLH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="30" mass="3472" checksum="8F8B529F0A155423" modified="2016-10-05" version="1">MNALTDLTSELSLFEERFKEAIKEKKDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLX7</accession>
    <name>A0A194QLX7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLX7"/>
    <dbReference type="FunCoup" id="A0A194QLX7">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106720393"/>
    <dbReference type="InParanoid" id="A0A194QLX7"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ05965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="54074" checksum="F850E5628FF84B98" modified="2016-10-05" version="1">MIANLPLLFANGNPIAISTISASQLEKFITFMVTCSWGHDTAKDIRQPPWWPEDVEFSHPFVKPAQVPQDWETRLKNLVRRCYNHHKSAFLLVFSAHLARLPRKRLRLVDNRDHTTSMYYRPSGRLLVTFRNENLFYDREESVEKEESHVKSADIYLCDNCDSHFDNLHTLQAHERLCNNEIPTSTCNGGLAEFLSALKLQSIQGIAQNASAKNVDIDTRPKNSRSAANVDRGPPFPFSSLAYMRNAKTNVNRDSTYSRERIERYCCTSTPLNRNVVSKSRNQFPIRYRRPIDYWHRTHIFPDQRNKKLLDVKGQLLYLKCRPVSVNVERMSLKSMTDYIEKLKKESENKMYAVDKDIVYVDGFDSDQAAEADIRSADPLKRLDNDCEVIDLCSDDEGPSGNENCDPRAGVTCVMRGGAVLRRAAATPNALPAEPCGARQRPLPALQHLPSAVLQPHPVILIAHTLNNLQTITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM36</accession>
    <name>A0A194QM36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM36"/>
    <dbReference type="InParanoid" id="A0A194QM36"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="78" mass="8995" checksum="A5D3C3B88F42051F" modified="2016-10-05" version="1">MTRRRRVCHSWMPRRVVGYSLSICMRSGSLVEKFLLISSSSTQIPLDNHAAHLIAAEVIQRYHYLYFVAEVLCGKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM68</accession>
    <name>A0A194QM68_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tyrosine aminotransferase</fullName>
            <shortName evidence="13">TAT</shortName>
            <ecNumber evidence="5 13">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_14198</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 13"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM68"/>
    <dbReference type="FunCoup" id="A0A194QM68">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QM68"/>
    <dbReference type="InParanoid" id="A0A194QM68"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="43"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="57008" checksum="5F5F157CC2835F90" modified="2016-10-05" version="1">MSQPGRRTQEWDVRASTLARNTHNLIRSIVENLTVEPNPSKPFIALSVGDPTTFGNLNPPEQVLQAVRESIELHTSRGYGPAKGHQEAREAVAEYSAHQGNVTAEDVILCSGCSHAIELVISVLADSGQNILVPRPGFMIYKTLAEGLGIVIKYYKLLPDKQWMVDLDDLENQIDEDTAAIIVINPSNPCGSVYNKDHLNEILDIASRNRVPIIADEIYEHFVFSGNEFTAISSLSKDVPVLTCSGLTKRFLVPGWRLGWIIIHDRHNILGKEVRNGLANLATRILGPSTLIQRALPAILKYTPQSFFDEVVLFIEVSGRFHETTIPNQAKMAYEELLRAPGLRPIMPQGAMYMMIEIKISHFPEFKNDLQFVERMVSEQSVFCLPGRVLNRYLKKPGLRPIMPQGAMYMMIEIKISHFPEFKNDLQFVERMVSEQSVFCLPGRCFEYPNFMRIVLTVPEDILREACQRLVIFCKEHIDIGEKCKEIDNNIIPVTNETEFICDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMB8</accession>
    <name>A0A194QMB8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMB8"/>
    <dbReference type="InParanoid" id="A0A194QMB8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="8663" checksum="554B5B5FE224CCCA" modified="2016-10-05" version="1">MRATLSVAGVELSGCRAVELCKRCAFGAAGPALTRRARGERAMPRSRRLLGRAFRDTTRTHCTLHSPGTASTHAIILSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN23</accession>
    <name>A0A194QN23_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein grindelwald</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN23"/>
    <dbReference type="FunCoup" id="A0A194QN23">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719909"/>
    <dbReference type="InParanoid" id="A0A194QN23"/>
    <dbReference type="OMA" id="CHAVSEY"/>
    <dbReference type="OrthoDB" id="6599193at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264500" description="Protein grindelwald" evidence="3">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26869" checksum="DFE2985AAD4883BE" modified="2016-10-05" version="1">MSRFTILLAVAGAASSQLTMDGVKCGQLTCLYEEYCSPETNRCAPCSAVCNKTHHNYDSGLCVKECQGYLLDLRYLRRTEYEPPNSNTNSAQRQAQTALIVSGVALAVLLLVLIIVCRRKISWRSIKQRFQPPKNQIKHFPSDLTHHNAHADFPRPKHELKLEIRNPEPAKRTTQPLNVKDLETRTSQTDKSQGATTPKTVSTAISNRHPAEDTTLDFSYDNMAMNVNPPEQPESTNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP06</accession>
    <name>A0A194QP06_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP06"/>
    <dbReference type="InParanoid" id="A0A194QP06"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264525" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11444" checksum="91F633E50A4FA68D" modified="2016-10-05" version="1">MQLVSRNLLAVMSLPLWALLETHQLSFIDLSSVKMLKHVAVSPHRARADSVSLASTASCCSLGSLEQRHDSVGDLSHRTADTAARPRSARHLLTDCDTTLGLQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ41</accession>
    <name>A0A194QQ41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ41"/>
    <dbReference type="STRING" id="76193.A0A194QQ41"/>
    <dbReference type="InParanoid" id="A0A194QQ41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tRNA modification"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="22178" checksum="541C346105D508C2" modified="2016-10-05" version="1">MLIKSTPCFVQVYKGLDIVTAKASRQERELVPHHLLDLLEPHQMFTVVDFRNRALKIIQNLTEKGKIPIIVGGTNYYIESIVYQILVEDMNDSNALLWEISKRKRDYVQNDESKPKKLAGDCKSDVNKEKLDCSDVHEVEDVVLGQTMVRWITHHVARDVMPAIRKSAKMLHTTCVVSRVRAPPPAPASIHSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQG8</accession>
    <name>A0A194QQG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQG8"/>
    <dbReference type="InParanoid" id="A0A194QQG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2_4"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
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            <end position="54"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="770" mass="90960" checksum="22629E1D1FC56D79" modified="2016-10-05" version="1">MVEGLMMYRKVKALSISKMSQNPTHYVCDYCSRTFTRKYNLQTHIENYHMNSSCYCEICDQRFGSPAGLQLHLSRGHNRFGQAFPECDICGRIFTRKQNITSHMITVHLQSGRPDIRCHLCEKTFTTERNLKRHKNQLHNPNAEYPICDMCKKVFKSKSALITHIVSTHQHVDKDSLKCQLCSKVYTNNRNLKRHVEMFHGERGEFKCPICPKVYTSNQSLRRHNKTMHNPDSVQFNCQICCKEIYGKENIDEHVILCTQNNVPEYKETEIISEPMYNCINCDKSFNKEPLLRHHVKTEHTFQDFYNYCKKSLLEMMTQTPTKDYICEFCNNTFNSLHELKDHLLFIHEKYYNLSTCNVCFTKFSTNETLLEHRKFCLPPPDVNACEHCDRLFTDIASLEFHMKIFHPQAHLSSSSNDEYTDQNYKCEYCDRVYNNQKSLKHHIKLKHNKEQSFDCHYCGKVCSNKYYLTSHIKIVHSNISCSKCDYCDKWFKSKRNIRRHIEYTHLGMQRHKCIECETLFKEKRSLRKHVRIKHPNSTLFPQCHICYRRFESAKSCKVHLKLIHSFNLSTHPCGLCSISFSSIEALKEHLETNHLAEDEIYKCDECNLLFKGQNKFDQHKEIYHSNLIWSGKRKSVPRCVICMKDFSSRKTLKRHIKKFHNEFDVDDLANYSWLVKITNVDCDECIKIFTDDLKNIHYDKLKESLETIVYKCDTCLTSYNMLEYSVLRHKLNISSRGKMILSEFCTAELSEGEDELNLSQDMEPESTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQM8</accession>
    <name>A0A194QQM8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">RR48_11210</name>
    </gene>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pmac:106718636"/>
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    <dbReference type="OrthoDB" id="7467515at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1208" mass="131534" checksum="AAA232062BC03AC9" modified="2016-10-05" version="1">MATIIESESPPSPTNNESDGEADQDDFEEEKYDIKPKNTGNGFADILKRLESAGALLKKPKKEYRCKTCDEDFVDWEDLENHLYQHVSLPSVVLERLPSDYEDTVASEDENWSDDEELQLPLKREAHKTPQKVDISQILKKTGLTIKKSETGKSSDAALNKLSNLGFTIKKSSTPIKKEKIEERNETRDSERNKKVGNIKLKLKSDGNNINTFKVINGLKEFRTSDDDDEESEHEGGNDEEFGENKSKNKNQDDDEEDFEADSDEEQHLNDSRRSSENSESGKNDLLNQMKKFQGKQIKIEPIRIQKSGSLTIVKQLPAKISIKSDASIEQNKEILKRETPIAKSLGRPSVKQTPKRGPNNPLPIKNQESQQTSDSPSPTKEVHKTPERRESQEVNTENVAVKQEVHDSTETESKNVPFVSQEIKSERSSPPLDRAPTPIIAKIKTEPSVSNATTTANSFLPVTKTEDSNVTIIEINGDSNDEDDDCCVVSSTPAPDVKPIIPKTEVATPLPPPSYSTALPYPASSQPSSYTTAPVLSSRLSSTPSLEKQHNFNWNAPDSKPPIDMLEKSADDIFESLLSSSTKKENMSSLSDVSEYISLDTLGPKHTCEVCNTRFTDISLFEEHKRMTGHSNSLVAPSSSTLLPYNPASNLLSSLLPVKLAEQVGKLSTIGNSGPGFTHQQNVMINIQAYPGAGGVMQPPPQPYNSYGPQGHNQQGGYAQAPNNMYTSSPGQSMPGQYPGSTYPQSPGYGQYPTPMSTPGYPGTMPTNVYSSASSPYSTASPLQSMQQAVYGQSATGMMNQQPATMMAPPGSSPSQVYSSASSPNAMKQSSNIRIQNVQTFPPGHLGQTINSGQTATSGQQVGSNQQPMHGHNISMGQPMPGQITNPTQIRMAVGANNPALPRTRMPVVRGPRQAVRPAVHHGQIRGGAAKGPRMPLKRPGQVIGGTPQKRRTDMLLPGKHDNEDCQVMSMQKQREGLPLIHSVQGAKDKLNLGSQISITKKTVNKEANAMANVLASRGISVKQKQKSRSPSPPRALPNLPNIPGVSIKHSSKSSNFSIPEAKIGGGMLSCKICKKMFMSSTSLSVHMSNAHPQSKLPLFKCDECPASYPKSLQLQHHKRVFHNVTGPDRELGLPVVDLSQVDNLQRLSSLGIYSFIPLANREQGNGCFGIPVISVHNVQNGLTSGLQALGADGLLSLGPLKPLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRV8</accession>
    <name>A0A194QRV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRV8"/>
    <dbReference type="STRING" id="76193.A0A194QRV8"/>
    <dbReference type="InParanoid" id="A0A194QRV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBE2O-like tandem tSH3-B" evidence="2">
        <location>
            <begin position="138"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="574" mass="64031" checksum="6B96E1D4D3758AF8" modified="2016-10-05" version="1">MAGQNPGSPTDFQYFYEDEVYKINNRGQVVFGLVLENYEANSSDQESDIETPIQKGEIRVVWHPSGTERVISEKSVGLADRSLMPGDVVRRLIAGKDTQRGYCRDIVMTAALQIVGTKHVIPSVASERLQPLEEFTPDLAVCLDSWVGTSKAVHSKLRLVSADGSRLEYPDLDSCPLEDYSMRRRRSTPYSSSEFYPGQVVYGPLGTLDSANWLHVTKEMKAARKHKMHDHKFTVEAVVTESVSVHWQCRALSTLVTDSNAPQQPKFLVEGEDLKNLKLLNVFEPCTLQVGDRNFLTIGPEDTYVSKKHWRKHQSKFYRNLRKQSRPVKKPSKTDANSTEHIPSRPKKRASSHRKLKSTDVSKFYRNLRKQSRPVKKPSKTDANSTEHIPSRPKKRASSHRKLKSTDNEMEVDGGDEKLESLDEALKADLNCPSIKIEPSADVTMPVCSSQEDTATEEKNDSGISPEPSKEDSQLLNGDSKVGDSCLNDDDSDNWENTSSDGSDTDSSQEDTATEEKNDSGISGLSKSHIRSPEPSKEDSQLLNGDSKVGDSCLNDDDSDNWENTSSDGSDTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS33</accession>
    <name>A0A194QS33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRCA1-associated RING domain protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS33"/>
    <dbReference type="STRING" id="76193.A0A194QS33"/>
    <dbReference type="InParanoid" id="A0A194QS33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="39346" checksum="A976F275503FDF3C" modified="2016-10-05" version="1">MHTKRIQPKRGLSKSVQSQSSGLESIQAQVSEVNPQGRPKPVETQSGEYKRVQSQQEKYKRMHPKCVQPKRGKLFQPGSEKPECVQPKRGKLIQPSKLKGVQPQSGKSKEVQPLQRKTCIQSQSLGPKFILPRRGRLIHRRGHPKPLQPKRKKHKPTQPLPGTPQQPFTDVPVSLRIQTQIAIKNSQEDIIQEVSLTEKRKRNRMNAEGTGRTFLHTAAFNGSHTKVKTHLKKGRNPNTHSSSGWTPLHDACLYGYEKVVRALLKGEAIVDIRGPNGETPLFDAVTADNFKIVKLLLKYGADPHIKNFDGLEPSYYANTAIKEYLQKLKDHPKTSQVGCTRDELHQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTB8</accession>
    <name>A0A194QTB8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trinucleotide repeat-containing gene 6C protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="532"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
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    </dbReference>
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        <property type="entry name" value="RRM_GW182_like"/>
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        <property type="entry name" value="GW182_RRM"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="UBA"/>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="PROTEIN GAWKY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
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        <property type="entry name" value="M_domain"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="731"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="672"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="966"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1039"/>
            <end position="1078"/>
        </location>
    </feature>
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            <begin position="1146"/>
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            <begin position="1321"/>
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            <begin position="252"/>
            <end position="263"/>
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        <location>
            <begin position="270"/>
            <end position="286"/>
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            <begin position="287"/>
            <end position="326"/>
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            <begin position="349"/>
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        </location>
    </feature>
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            <begin position="494"/>
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        </location>
    </feature>
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            <end position="541"/>
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            <end position="1068"/>
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        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KPJ08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1355" mass="146322" checksum="A2E371A876065E53" modified="2016-10-05" version="1">MSNVSVILCVPHLIKDNCYSNIDTVTEPMQCKNSTLMLVVNTNKFGACKRVEENESQQVSVKMVDNNIYNVEFVDSIQQNQMIGDMPNYCIPLTINAITVQGISYSDPYFSSFNLKYKMALGAPEYMNKSDYAFKSSVCIIHEPCMDKTQLLNEKAFRLSKTKTRMITCDNKFVEAKNDNNTSKVDGQSTSKRAMRTFANGDLTFDAMLELVDSEQKIINDLKKSHQVDLWGVPRRFRLCGGGESSLNAAAGWGSPPSSNNAGNWGGNSSGQTNNGTNNTQQWNNTAQRPPTSQADLNSNKSNGNQMPPTNVSTAQGWQNSGPNMQNAPPNNNGAPASNGTNNGGNGNNGANNPSNPSANSNGPSVTNGNNGNNGNSTSSAKIEQLNSMREALFSQDGWGGQHVNQDTNWDVPGSPEPGSKVEPAAGGPPPWKPNINNGAFLGTDLWEANLRNGGQPPPQPVAKTPWGHTPTTNIGGTWGEDDDAADSANVWTGPPPPQQWPAGPPQHAQQWGVPKKDDWNAWGEPHRPSDPRLDPHRTQDPRQQASDPRHDLRGGISGRLNGDMWSQHHQHTGGPSKMMTSAGVNQWGSQGPKDPIKATGWEEPSPPAARRGFDDGTSLWAQRGSIGGMQGRGAPQGPPVQRIPPTPTKPDAVWSAHTQRNGSWEEPHTPGWPDRDVAGWPDASGPGLWPVPKPKPACPGGGWPDDIGEWGGPKLPQSGPLGKQIPKEMVWNSKQFRYLVDLGYKKEEVEAALRSRDMNTEEALELLTAARSETWRRDDHFHHTSFQPPSVPAVSPAVVQKMLNQPPPQPVQHHHSYNPNSGSSNSGQPSTAQLRMLVQQIQMAVSAGYLNHQILNQPLAPQTLVLLNQLLQQIKVLQQLVQQHTLALSKGNSTLAVQYSVQISKAKQQITALQVPPYLPPQGYGSRGGGCPTSPAPNGGSDVRSRRRPYRAAEGLDKPVPPPRPPLVNQIATQQALYMKQQAGGADLFKQNHDPLNHLQNNFNEISISKDSQSAYGASSNQQSRLTQWKLPLLEKDGEGSEFSRAPGTAKSATSPPLNQLGLQPDSTWGVGRSSEGWGDSGADVADGKDAWGTHAVHQPVYDLVPEFEPGKPWKGNQMMKNVEDDPAMTPGSVVRSPLSLATIKDSDMLGGKTSPPGSERSLSSSTWSYAPPVSNSSATGAGLKSDAWGTKPRPTPTGIKAWPQHVNQRVLPTWQASTWLLLKNLTAQIDGSTLKTLCVQHGPLQNFHLYLNQGLALARYSTREEAAKAQMALNNCVLSNTTIFAENPAESEVQMILQHLGSGGGGAWRGGAGGGGKDGWGYPALWPDQHDQRATPSSLNSFLPPDLLGGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU26</accession>
    <name>A0A194QU26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integrin alpha-PS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_12248</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ08495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A194QU26"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 18" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="454"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="618"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="771"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="897"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ08495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127884" checksum="35C19A359626FEB0" modified="2016-10-05" version="1">MACGNTYTFRTCRNPIHCYRAPHPHARYRFDLYNSFNGIFGIIPILLSRLLVGAPLGQNLQPNTTRSGALWRCRLTPALGDCEQIITDGKTLDSYTLTAPYEDEIKDGQWLGVSVRSQGPGRKAVVCAHRYIRKSGESQFGQGLCYTLSNDLQLLDSWEPCRGRSVIKEHEEFGFCQVGTSSSLLEDDTLLIGSPGPYTWRGTIFTHDTNDDLLERDMSFYMAPVEDGLSPVEKYSYLGMSVTGAGFFNSVPSYAAGAPRARGTGQVVIFSKRVIKDWGRTDIDILEYNLTLNGEQFGSSFGYEVASADVNGDGLPDLLVGAPFYFSRDSGGAVYLYLNNKFSLRQEYDVKITGKPESQFGIAIANAGDLNKDGCEDIAVGSPYEGNGVVYIHLGDRKKGLHTKPDQVIEAESLPRVMKTFGYSLSGGVDLDANGYPDLLVGAYENSSVALLRSRPIIDIKTSIKPSNTIINIDPSKQGCTKDPISNYTCFHFEACCIIKSLVKSTQAITHELSYVIEAETFSGGRKYSRVLLDSEKTNIVNKTLRLGKDVEVCRQHIAYLKNNTRDIQTPIKFLVTYKLVNVEPVFSTVKALPNIDDFPVLNATAVTAFSANFLNDCGTDGICISELRVVPVLLLPKSEDGNSYALTLGQEEEIKLSISIDNLGESAYEGQLFVQHHPSLHYIAANISDKHMICSSVNKTIVSCMLENPFKKQPDGAAPVIMRFDARALEDNEATISFTVWANSTSKERYPGKKPAKVEALIIKNAELLIKGVARPEQVFYGGEVKGESAMTYFDDIGTRVVHTYQIFNEGPLRVSSLQVVISWPHQVAAEGPQGKWLLYPEDLPTVDGDGDQNNGECFLSDGEINPLKLTMRPGSTEPLLENLEMDPFLTTGKLSVSSNQNNGECFLSDGEINPLKLTMRPGSTEPLLENLEMDPFLTTGKLSVSSSEKFNKEYNRTRKVIEYSAASENKVRRKRENDVVKAEAYTDKDGHRKHVVNMNCQKKTAKCIQFHCIIYGLRRMQASTITVRARLWNATLVEDYPRVSHVNIASSAALRIPEHYNIHQSKHHDDVATVETVAYPDLKISEPSEVPLWVIIVSVIVGLIVLILLIIALWKLGFFKRSRPDPTLSGNLEKNNHESSPFIGRDRNSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU31</accession>
    <name>A0A194QU31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar fusion protein CCZ1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU31"/>
    <dbReference type="FunCoup" id="A0A194QU31">
        <property type="interactions" value="2251"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU31"/>
    <dbReference type="KEGG" id="pmac:106717938"/>
    <dbReference type="InParanoid" id="A0A194QU31"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="3">
        <location>
            <begin position="200"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="4">
        <location>
            <begin position="343"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="451" mass="51623" checksum="9BA18E60924A8131" modified="2016-10-05" version="1">MIDIESKINSFFIFNSTFGPKEGEELKRILFFHPSQISADARKIQVGLCEAVVKFMSTFSSEPCEALQTQTKRYIFYQPEKNYWMVLVVRIPYATKALSSIGEKKGEMIQPSIMQNLLVTAYKMFRMFVGLFTDVPADMIYTKCQQFFTPYILSRCITNDVTNVIQGINYLPLEKNSFLKIVCFIDLLEINFQDFKCIGFIYNEQLIWNGLSTDDMLTLYQYLVQSLLPKQVEKEIQGGAVTAAQRHGRFITPSDGIHTDEDIDKLIKVYLKLEDDTETKQYYLIIYRTLSATICLTVNADKTLELETLKTLDAFIGPQLYTIASTISEQCTLHALQNAQLANTEKKFLYFNRINLAFKSSVPINSLSPSTAIKPEVLNIIAGIHSDRKSLGNHGEIIIKTLDEYWITGKSSNEREFYVIIQKKNANVIEIAEEVKQVCEGQMKGIFFYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUX5</accession>
    <name>A0A194QUX5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUX5"/>
    <dbReference type="InParanoid" id="A0A194QUX5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="114" mass="13330" checksum="4A401BC5E8AB09F9" modified="2016-10-05" version="1">MNTKEKLMKCRESLRKFFRHDIFGAVTATKVWRESQHYHRLGITTSPSPPITPVLHLRDEETTLFLYALKHTVAIYNDNTIFVKQAKELFRYLCEERGVSRMSDAEAGRELRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV85</accession>
    <name>A0A194QV85_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV85"/>
    <dbReference type="InParanoid" id="A0A194QV85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="781" mass="87689" checksum="66D6A93BC79F65F3" modified="2016-10-05" version="1">MDTVLQFSVIRNFVGKDIPNNWRFYLIPHTFGPPPRNLFAAGCHGNQPDKCKHLALLVAVASVQIQADRPKKKIRIHLPQTVKHIHHHKKIYITNHPASSQYAPAFMPNAEGAVAVPTNIALPTVANIVPFNSVDILEDSVRTPGLTASASKLIPLYHARGYYGPTHTEIDEQEFDLASIPEPGDSYVFPSPIIASPQDTNHHSSKRIKVVKVSEPPRKKIIRKAKPKRIPVRKPVTTVQQENELPVSTFHEQFYSDVQDAGTIRKFKKPQRFEKIVDGNTEHIHTYSEEHIHKVVFDEEPKYTGIVGLESISGIPAYTHPLLPLKQSQILAMPSDPYRTVAIPGSMGTPAQYEYAAYNPREVTHDHFFHDHGEIPEEVDITRDIYSIPPKVTYNSQGIRIDSPLPKRVKNKYTHRPTKTSSGDYTYYENVYSSSRVKPTKTAAPAPLYVSQNDNGNQFKSVSTYRYKDGVSSKARNKIPTYFGKPTPDYRVKKPSNVPYSVSSKIVHEYKPTQQSYSGTAPGSNGLSAYEDQFANFKDSFVNNYEYDNYASSSNVHQAEEKNHHHAYGHQGRKGRKKSISSQNIRFGRQNGKYSENFANENILVGDNDGAPSALDGESYDEAVIYDSATSASLTGKESSPYQYYTVMAVKSLADDQLTVPEASNNNYQYAEAPTPAITPNPTVATTTTLASELLANQNNFEFTTRPTEIIKEHKYNKKYPENNAITVTNAPPSERHRGLKEMKNSDNFHKIRLQSSEKYTNNVISTTSTERSQVKYGDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWD0</accession>
    <name>A0A194QWD0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipopolysaccharide-induced tumor necrosis factor-alpha factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWD0"/>
    <dbReference type="FunCoup" id="A0A194QWD0">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWD0"/>
    <dbReference type="KEGG" id="pmac:106717273"/>
    <dbReference type="InParanoid" id="A0A194QWD0"/>
    <dbReference type="OMA" id="CSARVMT"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="13935" checksum="6FF7707A3AFE5C57" modified="2016-10-05" version="1">MEKMGNPPPYGWGNGPRMQPPPAAPPSYSQAVGGVGPSSPYTPQYPATAGPPIVTTVVPVGSHPTHMICPSCQAEIDSETQTKPGIIAYISGAIIALGGCFCGCCLIPCCIDSCMDVHHRCPNCSAYLGRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX46</accession>
    <name>A0A194QX46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0764 protein C16orf89-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX46"/>
    <dbReference type="STRING" id="76193.A0A194QX46"/>
    <dbReference type="InParanoid" id="A0A194QX46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039178098" evidence="1">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="46296" checksum="B2390C5743C6A5D8" modified="2016-10-05" version="1">MNVKQFVFLTACIAAVAAIYPYFDTQDFIYNIPKVYRISITLDKLLEYYEKKQSKDPEWFIALGVARAQDFLLSITLDKLLEYYEKKPSKDPEWFIALGVARGQLEYTINELDKSVPPKLKENLQNITRKMDRIRNNTDTSKFTYRSKDYEYVVKAIIENMDVLSSLMEPLTLGTVGTQKPYRFSFEQYVQEARTKMPTRKAADACTMQLLISAMETQTTQSEGACELTPECQAQLMKGSGLAFQQTSRVRAAALARLFDCMEGFDLSAHIYKLCIQIYKETKSLEAWGHPPGTKTLFLQQILYCSSQGYGEFIKPRWMNKILAWQEPKGCYSDDRKSFLKLTGFVGPASSPPPKDREEEYRVKKVATSVGGSCNSLTSAMALGSLVMYVRALLETDQAFQYDVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXS1</accession>
    <name>A0A194QXS1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRP18 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXS1"/>
    <dbReference type="STRING" id="76193.A0A194QXS1"/>
    <dbReference type="InParanoid" id="A0A194QXS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="7">
        <location>
            <begin position="564"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1185" mass="136143" checksum="8828E3C2134462D2" modified="2016-10-05" version="1">MDILKAEIAKKRKLLEEKNILNPTKKYFKRGELLAKEQEEYFKKYGLKPEEPQSDSKEDEEKVNKQENESKQTESATLPRTEVVKRLRERGHPITLFGENEVQSFRRLRRIEIQEPEANRNDNEKAHNEDDLDDSITYEFIQEMAKTMGQGDRNHDMTVIMTLLQYLLKMWGQQLNSATAAEKNSVKHKMARATYTQTQVYLKPLTRKLKKKSLPEDICDSLMEITKHLLERNYIMASDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYIQALKRLMTKCQDFMKLFETYPDVGDKVLCSPVQSLPICNHDIIKAQQTILESEEYKTLISQLRYKFLKRNVRARFFGLPVCPELHRTVFPKNVDMGCFLKVSGTVVRVTQTKMLEYQRKYVCMKCKFENCIEADFENRYILRGPSKCGNNDMRCKCSTFTQVNLVSREHCRDYQEIKIQEQVNKLSIGTIPGSMWVVLEDDLVDTCKPGDDVNICGTIRRRWRPSVQNKKSEVELVMQANYLEVSNAQRSEVIASAPDVKDCFNEFWSKFEACPLKGRDQILASVCPQVYGLHLVKLAVILTVITGSNHAFDDDTNKELKEDKYAMHVRGQCHLLLVGDPDSIYDEMYSILDVTLFVGGVVMRFIVYLQEDGEWQLEAGALVLSDGGVCCIDEISHLREHDRTAIHEAMEQQTISIAKAGIVCKLNTRCAVIAACNPKGHYQTDEPLSANVSLGTPLLSRFDLIFILLDSKNKSWDKLVSSYILHGAASAKQSKTKWTIEKLQMYIGLVGPRCTEMTKSANAILQSYYMLQRKSQNRDPSRTTVRMLDSLVRLSQAHCRLMYRTTILTVDAIMAVSLVDLSMQDCTLNDTMDALHSTFQKYPDFDYLCKARMLLERLNLNQIWKEELLYYANLLQTDRKTLETDIERGSTKLFTKYDELTDDNIPLSCSLITSTYFKKDEKPNHSNSKKENLNTGKQGINDRLAATLKKHSTLNKVDDKLPDPRKKMTRKRKLKEITADVSAIMKNKPKFSKKNKIESDSDENNDSTAMLNAVPSVNDIFNDLDIDLINDNESNTIETEDNIEKDSEQDKRYFNKANESTNIENKPCSKTLNFLKQFEYVKKEDPNKSEENIKDNEIILLNSIKKEPNESVNKSFNKPTSSSQISIFESTDCDIDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ08</accession>
    <name>A0A194QZ08_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein HGV2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ08"/>
    <dbReference type="FunCoup" id="A0A194QZ08">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ08"/>
    <dbReference type="InParanoid" id="A0A194QZ08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="7">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="431" mass="46617" checksum="FCE95E0BA368F7C1" modified="2016-10-05" version="1">MSQVASNELTKAEFLTSLSKQQRKPLLDVSIMADVADVSTSSPVELLSVGRRHLAVRDYSAAVEALTKACELLAAEHGDTADQCAEAYLWYGKALLGLSREESGVLGDGMPGTGNADEDENGDQEDNDEQNEDGEEGTEAEAKMETQDDSADSGTEVEKTEAESTTKDDEPTVVAPSGTDDEKPGTSNGDAMDESMANLDNEDDVDNLQLAWETLDLARSILKRRVEAGGGDAARTLLADVHLALGEVALESETYDKAVTDMMTCLEIQKELYSSDDRCIAETHYQIGLANSLASNFEDAVTHFKNAANILESRIKALENANPKDDATIKKYKLNDPFYSIEAEIKELKELLPEIQEKIQDMIDCKAETIKRVRETLCPANGEGSGEPSIASSTSSEPKVKPAASDISHLIKRKRKASDGEADSASKRVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZM7</accession>
    <name>A0A194QZM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZM7"/>
    <dbReference type="FunCoup" id="A0A194QZM7">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZM7"/>
    <dbReference type="KEGG" id="pmac:106715789"/>
    <dbReference type="InParanoid" id="A0A194QZM7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="24627" checksum="788A6B0EA40DA3D2" modified="2016-10-05" version="1">MSNEHTLDLHYVHQSFQRSLKEEDDVVIEAYIDGYNELVKFLNLIGSVFSFVSSDVKSKIKVMEKHREGDDAIYYESFKKMMKYEKETCLHEKNGFVSGSRTMLRLHRGLDFIRLFLKRLSDSDDAVNTCTTCQSSYNETLAEFHPWYIRKAATLAMHALPTRPDLLKKIFGTEDRLTEAMTILPQTLQSCDEVYQRVEQLYTDFDFHGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZM9</accession>
    <name>A0A194QZM9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZM9"/>
    <dbReference type="FunCoup" id="A0A194QZM9">
        <property type="interactions" value="1521"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZM9"/>
    <dbReference type="KEGG" id="pmac:106717180"/>
    <dbReference type="InParanoid" id="A0A194QZM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000477">
        <property type="entry name" value="gamma-soluble NSF attachment protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="325" mass="36022" checksum="2F00516C670960A0" modified="2016-10-05" version="1">MSAKMNEAHEHCKAAEKFLKTSLLRWKPDYDSAADEYSQAAQCYRIARDLKSSKDCYIKASEMYKKNHSFFHAGKALENAIIVSKEISTPDEIFTLACDSSSLYQQHGSGDSGANVLDKAAKIIEENSPEKAVKLYQQAADVSSVKHCSQHQGSEYISKSSRILVKLQRYDEAVDSLRREIGFHQEAGNIGAVGRLTVAIVLVQLARGDAVAAEKAYKEWGNNCEAPEMQTIEQLLQAYDEEDRDSAKRALASPFIRSMDVEYARLAASIPLPEGIEPPPKAAVRENAAPSYVSPNASYMQAKSDDNKADYTYEEKKTDDEDGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZP2</accession>
    <name>A0A194QZP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZP2"/>
    <dbReference type="InParanoid" id="A0A194QZP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11749" checksum="95A3C959CBD7A397" modified="2016-10-05" version="1">MDVDSLSKLEEMLKTVDGDKTPSRKELLEMLEQSEMEEEMKENLRGMLSGNVPQLFGSYGSGTYLGILFVLIIFGVLCKCSFGGGWLLVKNIMTDVLKNVVYAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2A9</accession>
    <name>A0A194R2A9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2A9"/>
    <dbReference type="InParanoid" id="A0A194R2A9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="69" mass="7721" checksum="4CB97E51E7179851" modified="2016-10-05" version="1">MAPVVHSYEKYTVQTGCRPDLAQFRPVVTLEGMSGDQHVPYIPCEFCAHHLPLDLIGDHQSYLSIYSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2Z4</accession>
    <name>A0A194R2Z4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WASH complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2Z4"/>
    <dbReference type="FunCoup" id="A0A194R2Z4">
        <property type="interactions" value="1761"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2Z4"/>
    <dbReference type="KEGG" id="pmac:106714134"/>
    <dbReference type="InParanoid" id="A0A194R2Z4"/>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="1">
        <location>
            <begin position="564"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="3">
        <location>
            <begin position="923"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1087" mass="124787" checksum="AF055AE4803E6555" modified="2016-10-05" version="1">MRNDKEKEAGAFILKNYGQFFKRQYQDHLQICGPTSLVENKTFLPIKIDMIPSEHIPIPELVASDNIIMTKVLGVLSALCVEVSTLKKEAFERHFLFLAVYEEYPESDIASQMESICLLNAFISHCNDTLQNLCNQVFAIVSESHINLNGIQLHYIINNIGELFTIIILLELLISRTSLPTKWNNYCKSLKTFASENLDTCDEKFKAILGAIDNITAKIMSDDIVQNTLHNLLNLRKNNLIGKNCTTITSEFSQYIKQALSNLEKLVQEKPTTENMYKCIKINSLFVLSSHLFGGDKKIFKALVDLNTKAHSIHIIGTTMWFPEQFLQRYSPSLFSNHGKLSQTMLKARQSYMNAKKLSLSRDVAILQSISSQWILNVEEQFSNYIKLNAAEMNLHAKIILEGLEIASTIYHSLLTFLNLHLSLGIPLSKQTLMSLFEIIDILKGVKIAVTRNSNQIINSTTMIIQHLLFQTASSIQEVKKMLMCDKKYASKKLDELTCIVIAEQAVKGAATVERNTATNIALSFVPDSTYVDDTYVKLGTLLEKIQILTQFLNNMDKYCNCSWMLWHQNIIPVYFDQPFSRQLNALKLKNFFMVFEDCAGLLYKTDKYYEYAKIKDILNSATDIIDEKILNDMSQNIETNLRLHTHSHLKLDIVNPFTDDMIKKILLIANNLRISNIYTNVVPNVEHYLSKTFYNLTTVVLSDWKTYGEMRQMAKLKFNLSTVQDNLPKQTLEQGLDILEIMRKIHIFVSKYHYNLNNQIFVEKSSNNKHLNSINIRHIANSIRTHGTGIMNTTVNFTYQFLKNKFFIFSQFMFDEQIKSRLIKDLRYFKENAHSSGNMYHYKHAEKFNKGIKMLGLAEDGQSYLDLFRDLITQIGNAMGYVRMVRSGGRHCCSDATAFLPSLINKSFKQLCQENSIGDKATEAAENLDSNINDLVSNFVEGTEYFKLLVDVFAPVFRNPKNVHLKNFFIIVPPLTLNFVEHMILSKDKMSKKNKAGAAFTDDGFSVGVAYILKLLDQDANFESLHWFNSVWSHIKEEREIIDKQKNQGTLQLQQALALSEKKIKTLEEEFQLLYYSLTSARIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R447</accession>
    <name>A0A194R447_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mismatch repair endonuclease PMS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R447"/>
    <dbReference type="FunCoup" id="A0A194R447">
        <property type="interactions" value="1446"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R447"/>
    <dbReference type="KEGG" id="pmac:106713749"/>
    <dbReference type="InParanoid" id="A0A194R447"/>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="226"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="675"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="859" mass="97265" checksum="A19D1CF9AA94B6F9" modified="2016-10-05" version="1">MEDECNTKHTQVAIKPINKDTVHKICSGQVVLSLAVAVKELVENSLDAGATKIDIRLKNHGIDLIEVSDNGTGVTEDNFSALTLKYHTSKLTDYSDLLGVSSFGFRGEALSSLCALAKLTITTRHQSADYATKIEYDHKGNIINKTPCSRQVGTTVTLTDLFSSLPVRQKELHKNSKREFNKMTSLLYAYCLISLGVNITCSNQSNSNTKSLVVTTQGSISYKDNIASVFGVKQLENLLDIKTEYVPNIKENIFKGLSGEVKMSEESINVEDTEIDLSEDSNDAENNEITNTQGSVQSSQKSQGYKNGSSPVELVGYISTCAHGCGRSSTDRQFYYVNSRPCEPTKIMKLINEIYRQFNPHQYPFVFLNIVLERTLVDVNVTPDKRKLFLAKEKAILDVVKCSISKLFENIPRVMKLESAHSISNTQIVPDIEQPRIFNSFMQQFSNKSTKSDIKTNGSTEKKPELKRKSNTLLDYAISKSKRVEIYQNVNQDDIKLCDENDCNAEVENIINGDLYTPRSNSIVKIEPENNIDEQPSDIPAENEKPEVMYLEFSNELPNTQIRNITDVVIEKSKTIYCKTTNTPVKPVLAPTPKSKRQEIVTDKEELGKYNRKSITMKTSIEHVTKLAEIYNNQKQKIKPDKIKFKSEINPVHNKKCEEELSREISKDSFKDMIVIGQFNLGFIITRLDEDLFIIDQHATDEIYNFETLQKTTELTSQKLVIPQQLELSGVNEEILMDNLQIFKKNGFTFEINENALPTKRVKLLTIPMSKNWIFGKDDIEELLFMLRENDSEYCRPSRVRAMFASRACRKSVMIGTALSKADMKVLVDHMADIDKPWNCPHGRPTIRHLVNLAMVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4B4</accession>
    <name>A0A194R4B4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4B4"/>
    <dbReference type="InParanoid" id="A0A194R4B4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="18270" checksum="8F28366148E6EABA" modified="2016-10-05" version="1">MGKSTQVDGDNNPTSAESDPAKLLEAALLQMDGIIAGNTMPGCWHLPEHVTRWWLLDVCSQRLFGDDADSQIPQQAGGTATGATTPSGPGRAARARALELAQQLASSLQHAIPPPPRPDFTTASAILRWLQQNNNSVALVSGSSSEITNVTSPEVTHEKREREDRKTCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4R2</accession>
    <name>A0A194R4R2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dynein heavy chain 7, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4R2"/>
    <dbReference type="STRING" id="76193.A0A194R4R2"/>
    <dbReference type="InParanoid" id="A0A194R4R2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF1">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="10">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="11">
        <location>
            <begin position="279"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="468" mass="53190" checksum="AA41097C46560F34" modified="2016-10-05" version="1">MKAAATEPRVLDVIMIEKMLDRLKKSNNLLEMVQRGLNAYLEKKRLYFPRFFFLSNDELLEILSETKDPMRVQPHLKKCFEGIAKLTFTDDMVVTHMRSSEGEIVLLTMTINTAAARGQVEKWLLELEVSMKSSVHHVVHISYDDYSQRPREDWVLVWPGQAVQCIAMTFWTSEVTEAIHISIRAMRAYWDKCNYQISKIVDLVRGELSLQNRITLGALVVLDVHARDVLMLLIEFKVQQDNDFNWLSQIRYYWEEQEESGYQIVTRMINSQLMYGYEYLGGAPEGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDYIALGKFFKGLASCGAWSCFDEFNRIDLEVLSVVAQQILSIQRGINSGATELLFEGTLLQLDKSCAVFITMNPGYAGRSELPDNLKALFRSVAMMVPDYVLISEIELYAFGYLNAKPLAVKIVATYKLCSEQLSSQSHYDYGGYKFVSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4Y3</accession>
    <name>A0A194R4Y3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4Y3"/>
    <dbReference type="FunCoup" id="A0A194R4Y3">
        <property type="interactions" value="1077"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4Y3"/>
    <dbReference type="KEGG" id="pmac:106713753"/>
    <dbReference type="InParanoid" id="A0A194R4Y3"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="443" mass="49779" checksum="C415FFD038A90591" modified="2016-10-05" version="1">MSDDNVEDMEASSSSSENEEEEMAEDEENGPKTYLPGQPLKEDEHLVCDQSAYVMLHQAQTGAPCLSFDIVTDNLGSDRTEYPMTAYMVAGTQASSVHLNNVIVMKMSNLHSTTKLDEDQESDDEDDEDEEEDEEKKPNMTFAFIKHEGCVTRIRTTNFRNSVLAASWSELGVVNVWNITQQLQAVDDPILLERYNLSNVTTPVKPLYSFNGHQQEGFGIDWCPTELGVLATGDCRRDIHIWKPNEGGTWNVDQRPLVGHTSSVEDIQWSPNERNVLASCSVDKSIRIWDTRAGPQKACMLTAENAHQSDVNVISWNNKEPFIASGGDDGFLHIWDLRNFTSNSPVGTFKHHTAPVTSVEWHWTEPSVLASAGEDNQVTLWDLAVERDDDEVIDEELKNLPPQLLFIHQGQTEIKELHWHKQIPGVIVTTAHTGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R563</accession>
    <name>A0A194R563_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPPDE peptidase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R563"/>
    <dbReference type="FunCoup" id="A0A194R563">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R563"/>
    <dbReference type="InParanoid" id="A0A194R563"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="529" mass="58715" checksum="46BE2231AF27B22F" modified="2016-10-05" version="1">MKADIKYGRCAYSGAAYRLLEHNCNHFSDEVAQFLCDARVPEHIVAQPERDLPPPLRAALAAMLERALPAPDPAQGLAPNDLGFSVCNQAAYTNGVRGGREDSPDYLTLNNQIEEARLQSHELEQRRSTLAEKLARTQRRQERRQQRDRRAQPHHTPQDTPQDTPPDTPHHEMAECVELEEAAGPSSRPAGSAPDELEEAERPARAVRDPPILYRDIDAAAEFAGLTRALEAAGLELTAEERQSLDELRQYLVLGEGSWVLGDDFLNFIGRVLSEGGEGGKAGGAARRAVVRCLAAAALRDDVSLLLHQDRRQHALLAYAHRVDLLPPPEQHALALFMCNLFAHASSSEWLLYISEWEAHGQMLANIRVTTKVCVHCALSEEPELREAGTALLYNVATKEVKTVKRLLIHYDSDGVSSDISCSMHRSMHRSMHRSMHRSMHRSLATLYYVKVFDEVCAELALAALQLLRAEPAAEEEHVWRACSALARLAHHSPDVPQLVAVVGPDPAAYRGTSPRVDEQIDLILQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R714</accession>
    <name>A0A194R714_PAPMA</name>
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        <submittedName>
            <fullName evidence="5">Multiple C2 and transmembrane domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R714"/>
    <dbReference type="InParanoid" id="A0A194R714"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="75"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="227"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="609" mass="71381" checksum="0BC4DA9E0D63E6E1" modified="2016-10-05" version="1">MSGFYDFVPNLRDSIDRNDDGIPRSRNIPKSFKMWRSTSMSNLVSNSNKIRSHVYESAPSDNSKYASAESLTTLSSYKSKKSHWLLKDLENFWDSWDTIVTIILVAAKDLPRPPNDGTTHELYGKFRLGSETFRSKSVIHTRRPEWRERFKLHLHKDHSLKLTLWDRGRQKIFMGSCVLDLSKLEKERTHDIWQELDDGYGSVHLSVTMCVVRYLHTAPKTIKTDFQHEQVYWNNDWRLVGCLKVKVIRAKGLSGKPSAYCTLELDNEQLQTHSASSGPDPVWDKSYVFNVYDVTSALSLKVYSSSLTNAFLTELLGQVSIPLLNITNGETRWYALKNRNNRNVAKGNCPRILLTMTVTWNPIKATLRLFQPKEVKYIEEAPKWDISLLMRNLPIFVDHFNNILYFNEIFKRLFEWNNREMSAIALFFWLMLCYHLTPSMIPLTLLLVFIFLRIYTWIQGNNYFIDSGAEIKSENNSNNNQKENKGLAYRINDMPEIILTVSNVLELIVSFLERLKNLFTFQVPFLSYVVMSILALLSLVLYFVPFNYLLMLFGIYKFMRKYLNPDRILNNDFIDFISRIPDDRILKDWKELNVPEPFLKKFREKIHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7N6</accession>
    <name>A0A194R7N6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7N6"/>
    <dbReference type="InParanoid" id="A0A194R7N6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="13584" checksum="D31C60FCAC98BC64" modified="2016-10-05" version="1">MPGAPPQASTGRGSSAAPPAPGLGISVRWRSAQCQCGYIGTVAQCAVSVWVYRYGGAVRSVSVGISVRWRGAQCQCGYIGTVARCAVSVWVYRYGGAVRSVSAQCQCAVSVSVCQYRDGRRVAGCGGRLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB67</accession>
    <name>A0A194RB67_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the hemolin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB67"/>
    <dbReference type="STRING" id="76193.A0A194RB67"/>
    <dbReference type="InParanoid" id="A0A194RB67"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="9908" checksum="88A5B3805E152348" modified="2016-10-05" version="1">MQPPRFNMQPSSLNSIVREGTSKILQCSAVGIPQPMYRWLKNGVPLSEYSTDIFYKIHNTQRQDAGAYQCIAKNDVGAIFSEKNNNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBD6</accession>
    <name>A0A194RBD6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M-phase phosphoprotein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBD6"/>
    <dbReference type="FunCoup" id="A0A194RBD6">
        <property type="interactions" value="1262"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBD6"/>
    <dbReference type="KEGG" id="pmac:106710695"/>
    <dbReference type="InParanoid" id="A0A194RBD6"/>
    <dbReference type="OrthoDB" id="20403at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="137" mass="16091" checksum="B2418C5671816B4B" modified="2016-10-05" version="1">MSQVSMKKLQLPKSVLDMKFMKRSKDRIERELENTKGHEELYSNIITNEMRSATGNYVSEASFIYCEDLLEGRLSFKGMNPEIERLMELENAVKKGYGDMKKDVSDEDLLRNVEKLRKRKSETTPPSQYVFKKQKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBR0</accession>
    <name>A0A194RBR0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBR0"/>
    <dbReference type="InParanoid" id="A0A194RBR0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265054" description="Cuticular protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="11972" checksum="C2ED98B12283FE4A" modified="2016-10-05" version="1">MAKILIVALALVAVVSARPGYGGGIGGSSGGFGGSSSGFGGHSGQQGGVGGHGQSGFGGHSGLQGGGGGHGQSGFGGHGAGSGYGGGHSGSQSDFGFGSGGHSGGLGGHGGHGGLGGGSGFGYGHDKQNHEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBR5</accession>
    <name>A0A194RBR5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBR5"/>
    <dbReference type="FunCoup" id="A0A194RBR5">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBR5"/>
    <dbReference type="InParanoid" id="A0A194RBR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265061" description="Glucosylceramidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
        <location>
            <begin position="154"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="9">
        <location>
            <begin position="422"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="490" mass="55291" checksum="3A76EB91AAD659E2" modified="2016-10-05" version="1">MKILKLLIITLTILIGVFKPGDCDLPCRARDVGIEGRSIVCVCDANYCDTITKETPAKGTFVAYTSSNDGKRFEKSYGVVNGFGAANNELSNESTQDDDSIESNLCIRKNVVLRVMTSSKKQTIEGFGGSVTDAAGINWRKLSAAAQKQLMKLIPMIEMAKAMATDEVKITATAWSSPIWMKTNEAITGFGQIKPEFYQSYADYHMRFLEEYEKFNIKIWAITTTNEPINGVVPTVNFNSLGWFPRQLGRWVANNLGPTVRNSRFNETLILAVDDQRYIIPIWLRGMEKEDPKSIEYIDGIAIHYYGNFMPATVLTRIQKKYPGKILLSTEACEGPMPWDKNKVEVGSWDRAAKYTRSILEDLNNFVVGWIDWNLCLDENGGPNWAHNYVDAPVLVYGERDEFIKQPMYYALGHFSKFIPRGSQVVEVSRMSSATVPNIAVVTPEGNLVLVLHNMNKYETNVRIRISTLRYVDIVLEHESIKTVEINPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RED7</accession>
    <name>A0A194RED7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphorylase kinase</fullName>
            <ecNumber evidence="2">2.7.11.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_09998</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + phosphorylase b = 2 ADP + phosphorylase a.</text>
            <dbReference type="EC" id="2.7.11.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.19" evidence="2"/>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RED7"/>
    <dbReference type="FunCoup" id="A0A194RED7">
        <property type="interactions" value="1268"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RED7"/>
    <dbReference type="InParanoid" id="A0A194RED7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004689">
        <property type="term" value="F:phosphorylase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14093">
        <property type="entry name" value="STKc_PhKG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000138">
        <property type="entry name" value="Phosphorylase b kinase gamma catalytic chain, liver/testis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000149">
        <property type="entry name" value="phosphorylase b kinase gamma catalytic chain, liver/testis isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002291">
        <property type="entry name" value="Phosph_kin_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01049">
        <property type="entry name" value="PHOSPHBKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ15952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="464" mass="53030" checksum="3B067481052A9357" modified="2016-10-05" version="1">MAKEEDDDNLPDKDAAKEFYAKYEPKEIIGRGISSTVRRCIEKETGHEFAAKIIDLSQESQDGVDTHTMRDATRQEIHILRMVAGHPYIIELQDVFESETFIFLVFELCKNGELFDYLTSVVTLSEKKTRYIMRQVLEGVRYVHSKNIVHRDLKPENILLDDQLNVKITDFGFAKVLNDGEKLFELCGTPGYLAPETLKANMFEDAPGYGKEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGRYSFTSPEWADISEDPKDLIRRLLVVDPSERIDVHESLMHPFFNTVLWDQDMTPLKKSLSGTSRRMSRIEQLSMAIKSGGFNARAKIRLAFVVVRAAVRLRRLPHTAAQAVPLVDALRDPYTMRALRKVIDGCAFRVYGHWVKKGEGQNRAALFENMPKTELKSLYTSKDTQAMECEKYIKGIFIMHKGVNVYQGSIATDEVELRPAAPTQSHVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REX9</accession>
    <name>A0A194REX9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pro-resilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REX9"/>
    <dbReference type="FunCoup" id="A0A194REX9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194REX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="17943" checksum="50B1D23925519B0C" modified="2016-10-05" version="1">MAVSVAYHKFNVHRNGYRPQTCIALALVACVGAEPPSGYSYNRPSGGHGGGGFSGGLSGGGPLQPVPAGYQTSEGQHVDAQLLEQVRQILLKEEASSGSGFGGGHSAPSSSYGAPSSSYGVPSSSYGVPGYSGRVVDINLEGVRQAIQVAQYEQSGGSSGGYPSSSYSAPSGSYGAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGE9</accession>
    <name>A0A194RGE9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein KRTCAP2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGE9"/>
    <dbReference type="FunCoup" id="A0A194RGE9">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGE9"/>
    <dbReference type="InParanoid" id="A0A194RGE9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14236" checksum="CE271613DD020A7C" modified="2016-10-05" version="1" fragment="single">VNSATSFVLSSILTLLIFSGMQMYKPLLIRSPITIIFGGYLGSLMFLFFVTAVGNLEATLFGKNFQLKLPEIVLSMAISLIAAGMVHRICFTTCLIFSLMTIYYMNKLSQKTYAAVAPVAAPTKSRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH16</accession>
    <name>A0A194RH16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH16"/>
    <dbReference type="STRING" id="76193.A0A194RH16"/>
    <dbReference type="KEGG" id="pmac:106710578"/>
    <dbReference type="InParanoid" id="A0A194RH16"/>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265205" evidence="1">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="29197" checksum="7F8F6A8C8F97CFFB" modified="2016-10-05" version="1">MMRAGRFAVVITALLVCCNADPHREQDGSVNEHSSERYDANDYRQKEFDYLLRFLLQNEYRNGDRNLNGIGGSTLMGRNINGGLGGSTLLGRNVNSYEALKSGNRNLNGIDVSSLTGRALKKNLNGIGGSGMLGRDVGEYSELSARFVDPLGGSNFVRNLDSLGGGNFVRNLDSLGGGNFVRNLDSLGGGNLVRNLDSLGGGNFVRNLDSLGGGNLVRNLDSLGGSNFVKKNLDQIGGPNLVKRNLDSLGGGNFVRNLDPLGGDNFVRALELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIE0</accession>
    <name>A0A194RIE0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_08513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIE0"/>
    <dbReference type="InParanoid" id="A0A194RIE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="441" mass="49352" checksum="C0A5EAED6C9DB86A" modified="2016-10-05" version="1">MHSLSKAFVQVPRVGRLVDTSRQVKARRSPAGLSAVSGHAAVLRRAGYWRLSAGSTCVRRLHTVYRTMVFATTCIYLLQECFYAYQEKSDMAKLSRVMFLLLCHVTSLAKQLVFLTDADRIDRMVAEATRRALRTRSGSAHRLLHCAAAHVARLRRGYAGCAAFTCLLWAVFAAQAHARRQPFEFPLWIGVNTTDTVGFVIVLLYTYYVTTLVGIANTTMDAFIATVIYQCKTQLSILRINLERLPQSASALSTASGRRRDDVFAALFVDCWLQYKRICETAGLVQDIFGGAILVQFGIGGWILCMAAYKIISLDFISIEFASMILFILCILTELFLYCYYGTELTEEASISALLVDAAYSMRWAGEGRAARRLLLLLLVRVHRPLRLAAGRVVPLSLDTFVKVCLCPPRTFASSLGRLLLLPFYYSPFNRTHLLGLFEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIK6</accession>
    <name>A0A194RIK6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_07146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIK6"/>
    <dbReference type="FunCoup" id="A0A194RIK6">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIK6"/>
    <dbReference type="InParanoid" id="A0A194RIK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="539" mass="55766" checksum="16BBA6B3D22B774E" modified="2016-10-05" version="1">MGSAGVSDEYSPPRLSRLLHALPHVNVTLHRVNDTFAPNSPIYLESLGILGSIPGAWLILTLTVLLIYLLTRCCDRKQRPPRSITALKITLMILSVVCCGAIGVGLFGNDDLHNAVLQSIQAGNQLAGLINTVKNQSSILEEAMGSRARAPLARLADALDAPVANQTALGTLLRALSALRNNASAAASAADNLRRPLAALNLDAVMKRAWVWEAARWAGGMAGWCCGGAVCVALLAAAARRSRVCAGCAGGVLVCGHALLTAGAVAAADACQEPARAVAHYAPHHLPVDMVYYYLSCKVSRENVLTAELRNAQRAVVAVRQALAVLSRGAPQMFTDPVLQPALGALGAGTGEAERALVSLSGALECRTARAYFVAAARAACDGGLQALSLQLLAAIAAGFLFTAIVLVDSHAWIYINTKRSGGGEEQAPFLSSGSSAGSRSLPRPAPFPNGKPPSYSAAVQLMDLADRERPSAEVACARRSRMSGSATLGRASGGLGGLGGLGALGGAGGSHTLGRAPHNGKYATLSKQCKTLESSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIX8</accession>
    <name>A0A194RIX8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hairy/enhancer-of-split related with YRPW motif protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIX8"/>
    <dbReference type="FunCoup" id="A0A194RIX8">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIX8"/>
    <dbReference type="InParanoid" id="A0A194RIX8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11440">
        <property type="entry name" value="bHLH-O_Cwo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000079">
        <property type="entry name" value="CLUMA_CG001539, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="437" mass="48115" checksum="2B6CD71EC53E4950" modified="2016-10-05" version="1">MSEFACRCNACYNSNDGFGRVASGGGNAVAGEQLAFAAPSEDEADFANYKKGKQDPMSHRIIEKRRRDRMNNCLADLSRLIPPEYLKKGRGRVEKTEIIEMAIRHLKYLQDRVNASEVQAGSGEGHYRAGYQEAVGEALRYLSEAHGYPADGLCAQLATHLQRHCDHITKGDNSRDKGRSLGSSSETASSSSSSLGYGKAQPPPRPPPYAPDLYDANNDGPYNMDCDRVRGAVENGGTTSPACGEGGEGTGEREGDKRETLRKMRKPDHDDYIHSYKFKNSIERRFSRSQDSEAAESQARAANGKPYSHKRRRPARPAPAASTSASTSTSASASTEEARDTSPQDTSSESPHRHQYEQYEKPPQAQFVPVFALNSIGKYYVPLSVEYGCVSRQLRACDVLDARAPLAALHPVTIHVNFTPCLNYHVKRDPDPDWRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ27</accession>
    <name>A0A194RJ27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase/reductase SDR family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ27"/>
    <dbReference type="FunCoup" id="A0A194RJ27">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJ27"/>
    <dbReference type="InParanoid" id="A0A194RJ27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="378" mass="41318" checksum="1C98A34134C48732" modified="2016-10-05" version="1">MERWSNKTAVVTGASAGIGAAVCLSLANAGMQVVGLARRPELVEKLKQNITGKGAIYSRKCDVSSIVDIKAAFTWVDEKLGGTDVLINNAGVLYYPGFISDSCDKTITVEEISATIDINFKGLVICTKFAIASMNKRNFDGHIININSVAGHYIPSIAGYNVYPSTKHAVTAFTSSLLGELADSKHKIKVTSLSPGLVATDMAGKHVPEDIPMLQPSDVADAILYVLSTPPHVNIKENDIQEKTTTTSIPTTTKDQESRSEIDVINIMKECNESFRIQMSYLEQLNNSGSFPDETDKTPKCYIHCVLESSRVASEEGQFDAASAALVLTQLNDGYDTNELIDMAFQCTDRQEACKCERSYQFIKCIMEKQINKIENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJF4</accession>
    <name>A0A194RJF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Growth inhibition and differentiation-related protein 88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJF4"/>
    <dbReference type="FunCoup" id="A0A194RJF4">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJF4"/>
    <dbReference type="InParanoid" id="A0A194RJF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="556" mass="63369" checksum="5AB99FCAB4DD02EC" modified="2016-10-05" version="1">MTMERRIKLKTLNSHITCKICRGYFIDATTVTECLHTVLVFPPVSNYRRFLIHRCVERLARPDLATFSIGVSDERRTVVCYRERILRSGSAKPRRPDRAVYVPRALRGADNSSSDEAKADPQRRSSRSVEPKCPKSPSGRDKSAHGTPKRSIDKNFCNVYTPPHLRNQRSHTSIASPPPPEDNDSPPDCPVPNSDSAISFSDNSYNEVEVGETFYIGDYFANGQLGFYNPTYYEYDSRDLESYADEGFTNDHVTMEDTQQRIIDGDYVYSKDEDDEQNELKRASKEINRSTKRIIKQSFDSDILVISDPVEEEKVKQTEVEQKEKVVEKKTKPKLEAKVSLKRDENDWETVYDDSGECLDPSLLEELTSTVGKVHITKAKNNYDQYQTRGQALFNGPYDETFAHVVEVYDFPSEFKTNDLLSLFSEYKDTGFEIKWVDDTHALIVFSSAKIAAEVLSTQRSLARCRPLHAATLESRNKAKKCAEFLQPYRQRPETCTALARRLVSGALGVRLSTARQERAEERRLITIAREKKRQAALHKEAAWDGSLANQSVHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKU9</accession>
    <name>A0A194RKU9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative G-protein coupled receptor Mth-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKU9"/>
    <dbReference type="InParanoid" id="A0A194RKU9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265284" evidence="1">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="229" mass="26284" checksum="26EBAD5E4DB6698C" modified="2016-10-05" version="1">MYSELVLITVICLIHGSQVVIAAVGETDLNDLSEQQHSVVINKCCEENEVMVDSVCRLANKYNQSIWIPKFKTEDGKDAKLKYFKYLNGVPDCATTQQRPIFYFGKSEDELNLLTDGRLRHLIHHEHNAGSIKDDSITNTYSLHAPIVLNLLTDGRLRHLIHHEHNAGSIKDDSITNTYSLHAPIVLPEVKEPSSYIHDQNKYCMDKIYMTLKNIVFFSDLYDKHKLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKW1</accession>
    <name>A0A194RKW1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKW1"/>
    <dbReference type="STRING" id="76193.A0A194RKW1"/>
    <dbReference type="KEGG" id="pmac:106721777"/>
    <dbReference type="InParanoid" id="A0A194RKW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="41485" checksum="7DD0BB3C27C46AD7" modified="2016-10-05" version="1">MSSLQKSIMKNKLPPRVPRSSGIAKLAPFGSSRRKDYSPVSWKQYFDRCVDVETEAGSFRVYLSPEPDHPSRPRIFTLHGGGYSGLSWSLFTEEITNMIHCQVVSMDVRGHGETKVKDPDDLSIETLVSVQTGKLAINEVETYKKEDAPRAPEPTRHGPHANCITEESDEESDTSEASEAKLARTDSENEDIKLTRTNSTNSENEDNAKLARLDSTDSENEDTKLARLDSTSDDAEASNAKLPRSDSTEKDQSATFAVPNAVGDGASMKYKWRIELSRTEKHWEGWFGGLSSAFLHTRSPRLLLLASVDGLDRELTVGQMQGKFQMQVLTRCGHAVHEDTPGEVARVVASFILRHRLTTATENGELMNLVSAPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL07</accession>
    <name>A0A194RL07_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL07"/>
    <dbReference type="FunCoup" id="A0A194RL07">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL07"/>
    <dbReference type="KEGG" id="pmac:106709066"/>
    <dbReference type="InParanoid" id="A0A194RL07"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="36711" checksum="248FBDAE38504E1E" modified="2016-10-05" version="1">MHSLKRAIKLKVKSELRYIRTLSTVSDIRIYEVGPRDGLQNESKFVPTDVKVELIHKLAAAGIKNIECASFVSPKWVKQMSDGIDVMKTIKRSPGVNYPVLIPNLKGYETAMKCNIEEVAIFPAGSEGFSQKNLNCSVEEGLKRFKEVAVQAVKDGLRVRGYISCVVGCPYDGPIHPKGIAKITEELFEMGCYEVSLGDTIGVGTAGSVQRLMREVLKVAKPENLALHFHDTYGQGLSNLLAGLEFGIKTVDSSISGLGGCPYARGATGNLATEDLVYFLYGLGVNTNVDLVKLIEAGRYISNFLGKMTESRVNRALSDRFKNHSDIVKIAACTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM31</accession>
    <name>A0A194RM31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(RC)-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM31"/>
    <dbReference type="STRING" id="76193.A0A194RM31"/>
    <dbReference type="InParanoid" id="A0A194RM31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="17360" checksum="544D37A427DEEDEF" modified="2016-10-05" version="1">MTVPNELIGCIIGKGGTKIAEIRQISGAMIRISNCEEREGGSTDRTITITGNPDSVALAQYLINMSVELQKANLEGSTSGGSTASTNNPLASAIPLAQLLTKTGALGALNSLTALGGLTDLLSGSSSQPVQTTGVHRNHKNFTQRRQDDDSPSKSSKERNKYNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMA6</accession>
    <name>A0A194RMA6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
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        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="PCI_dom"/>
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        <property type="entry name" value="PSMD12-CSN4-like_N"/>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
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    </dbReference>
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        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
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    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="195"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="408" mass="46997" checksum="7A03EEDC064CB295" modified="2016-10-05" version="1">MPLTLQGVRQYLTELRNSGGLHKDQAEKYRNVLLEILVNPAELAESLKAFVEAIVNENVSLVISRQLLTDVSTHLALLPDEVSQEVSHFALDVIQPRVISFEEQVASIRQHLADIYERHQNWKEAANVLVGIPLETGQKQYSVDYKLETYLKIARLYLEVDDPVQAEAFVNRASLLQAETTNEQLQIYYKVCYARVLDYRRKFIEAAQRYNELSYRNIIHEDERMTCLRNALICTVLASAGQQRSRMLATLFKDERCQQLPAYSILEKMYLDRIIRRSELHEFEALMQSHQKATTSDGSTILDRAVFEHNLLSASKLYNNITFEELGALLETPPGKAERIASHMISEGRMNGYIDQISSVVHFETREILPQWDKQIQSLCYQVNSLIEKIAAAEPEWMAKVMEEEMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMB4</accession>
    <name>A0A194RMB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMB4"/>
    <dbReference type="InParanoid" id="A0A194RMB4"/>
    <dbReference type="OrthoDB" id="6107953at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="771"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
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        </location>
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        </location>
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        <location>
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        <location>
            <begin position="1106"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139666" checksum="9C97242E38BB6A5F" modified="2016-10-05" version="1">MNPPSALYGSMNKERKPFTYTPGGLDLSQIKSERMAQRLLRNAMDQGVPEQQTSHLQSPPTPTALNVPNFNCLPVQVFPTFPLPSNPKSLLKTRSNQQKEPCLQDIPNLEQLKTNINGIGLKQCFQNNNKNISNYNQSNNENKNNDQSLPLHEYTPPIVRSYPSYETSEYADAGSPKCYLPTEKEVITLEDNQYKYNDEIIKNKSICEPSVTKTSDTLLRPLLTSTYTMEKNIPETLEEMTGTENNQNEVKVVKKQIETENNTEEQNGDANVEAAVTIKLPGKKSSAKTETKVEVVKNVRPDGSIEEVKTTTTKTTIDGKTEIRTKTETTIIPKEEEYEEEEFVEEEEEEEENEQENPVVEETAASNEDQRENNVENDSEVDEDIKQEEKENLSQEETSETIITKQVTVTQSEQKQENSEETEEVEEEEEKEAEVESKNEENQIENNITDNREESEEDADDEDEEKIHIQNEKKQEPEEKDMVQENQEPEAKPEEELEETETVTPESEETRLEETMKTEDEKEKEVITDDSKSLTNVIKATVDNEPCDNEQSENSTVQSKDTKSTNEHKEEIIVEVQVLKPNSQETQDSKIENEVKSSLPSERNIPFREPSAPLEKVEDVEIKPIGEIISKTRTENTEIITSSLDKPTTGLSTQTAYNRIENIVTVNKTTKTLDHAYDQHAPLGIPTVKTYFAPTTDRLTTSPYQPVYTPEPQTERRHSLLLDRLSVDRQIPAAELYQSNYQTYEQNQWTQEPQSEVLTVSNVKPSTITKNQQWYQQTRKEEVSYDSAPSHNAPTQDWSTPPQQRQTPQPSQTQFQYQPQTQPSYIDKQDTFTSTLNNSNAFQQSTYQPTYTPKPTSWVGNNVNLPKTIPTINKPPSQYSYVNKEPTETYQTPPQPYSSSYIPPPWEQDSNYVPENLNQTYYTPPPSNKFTSNATPAWTPKPTSKFSKPKPTSYIPPAPNQSFVKPVTVNDQPKLPGRKTYYSEYERRYISVPESTYIPTENKFQAQPDPSPQYYYDNNEPKENVEHEWRKELREFSEKTQSQTFTDQTSVKPPWEEDPKYYAPTVTTEYTSTPTWSQTLRPSSWRDRSFESEFGRAKELARTNTLGRGRPQSSYVKSNISTPIPERTRGVSVDRYNPNNYKSPVPSEYPPVQSHTLDPTVGAKTYHNPNVPAYNSRASAEPREQTAAFPQPRHYAEARAPPLQSRSFKYLQWITGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMT1</accession>
    <name>A0A194RMT1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4795 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMT1"/>
    <dbReference type="STRING" id="76193.A0A194RMT1"/>
    <dbReference type="InParanoid" id="A0A194RMT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032013">
        <property type="entry name" value="DUF4795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16043">
        <property type="entry name" value="DUF4795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4795" evidence="3">
        <location>
            <begin position="541"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="650"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="841" mass="92802" checksum="8770F3C9136DB62C" modified="2016-10-05" version="1">MRRAFQRLDEPNMSDSTLLLKVEDLISMALGPKTQNLVNFKHMQTVLFMLARQLRMLEQQVEIRICESEEEIVPEVKKSEKKMRKRKTLQDQTGKKDTGFDKKGKKHKDTDETDEDTEVSGRGTKKKTGKSDEKQKKETEKTLDKEKKVAAKDIKSIEREKSPGDKRTPADKDITSSDKEKQTGYKEKLPGDKKVPEDEGKVPGEKERLAAIKEKADQEKKYAEKVKKQKIKAGISDSSIDYRDRKSRKSTGRAHVGNVEVVTQAEFAGLEAAVRQLEQLASHPPGLTMPDNQTLRDDLLHGTASLTEAMHTMQVNARVQAAEEAIGRMAGLLTQLAAAGALPAQLAAALRDGRIDLSAPGLGDLQQILLRQRKETARATGAWQTGPTGTTLGTMEGERAVDAATEPAAPPEPEPAPPPPALPTGLRDPSAPVTVVEFDSDLVTELKTQMSFEIQQITSKANSAADNAIKTAQFVAEKLEPAMGMAERINVLRILVADYADQLNGFDAGLSTQMQGFQEQMNQMRTELKSGLEQLAAVNNNSEATALAELTARYEDMVVGLDDVNTTHQALYTVQSKLSDELRNLVESVEMLRDQKSDRDEVLDALRDKADISRLAGLLTEEKFAEAHGELERMLDICQDKFKRQDKTWIRALEDIEKALEMKAEQTELMSSRQDVEARLQELHDLLQRLEEQLGDPIAALLMRRLGRGAVCGACGTSALMTPGVPPQPPELPALPAPHTARRPVPAADADSTQVCVPHPHVEDVKTPVRWCGGEHTIRSQLRQRARPPPRTPLTTRPYIGVGVDGRTYHMEEELQPCMECNELLEPRKDAAGGEGGAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMZ0</accession>
    <name>A0A194RMZ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMZ0"/>
    <dbReference type="InParanoid" id="A0A194RMZ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="36432" checksum="D155D0AA73DF55B3" modified="2016-10-05" version="1">MESPKPDLIAIYRLEFYKKKKNWKLSDAKKHKRDKISNLKKLLNQTYDVDEPKVEFSQLNNAFLDTEPDSNATTNNQLVNISKDIEDTNFVSNSVTEFQEIKQIKDNTVELVELPDISSLDGRMEIVQNYLDQHTEDVQNYSNNYRYLEDDKYWQDHNGNWRIVPEFTQYYPNDPTQVNNGLDCGDNAANTLDWQQREDPFWVPTDDLHWLSNLYSYGAVEADNCEIQTSDNSVDSWGEFVRGADVAPHSSEIELTLPKSLNEADVSANSLACLSSAQLRAAVQAHTNLLRSLINEENQRRVSLNKQRQYRTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ47</accession>
    <name>A0A194RQ47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ47"/>
    <dbReference type="STRING" id="76193.A0A194RQ47"/>
    <dbReference type="InParanoid" id="A0A194RQ47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="19418" checksum="DF35A0D910B39478" modified="2016-10-05" version="1">MSVMVWAYAQMSLALRGHGIGECTQYQMQIVRAKRKVVRMFVLVVVVFAMCWLPYHAYFVLMYHHQSSASAPIAQHIYLAFYWLAMANSMFNPLIYYWMSNKFRVYFRMALCLCRSVKNSTPDQLTKQFELNKSLSGKLTLKIVYIVLTNILTCRKRFLHYISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ91</accession>
    <name>A0A194RQ91_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_12039</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ91"/>
    <dbReference type="FunCoup" id="A0A194RQ91">
        <property type="interactions" value="1504"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQ91"/>
    <dbReference type="KEGG" id="pmac:106721684"/>
    <dbReference type="InParanoid" id="A0A194RQ91"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="481"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="567" mass="63126" checksum="CB2683D5EC2C3DC4" modified="2016-10-05" version="1">MKALVATVISLALTTVVIGNAYYQKKQFYPSIVYLTNSNPSMAVMYLQAFILVLLLGKVFRRIFFGQLRPAEFEHLIERSWYAITETCLAFTVFRDDFNPKFIALFTVLLFLKAFHWLAEDRVDYMERSPVIGLLFHLRILTLLTLLTHADFFFIHHAYQFTTSKGPSVQLVFGFEYSILLIMIINIVIKYTLHTIDSRWEAPWESKAAVLLYTELIINFLKVLLYIGFVAVMVRIYTLPLFAFRPMYETMRSFKKAYNDVVLSRRAIRNMNTLYPDATAAELAAADNECIICREEMHSGAKKLPCNHIFHAACLRLWFQRQQTCPTCRLNVLRAPAPDTPHVPDGIPPGNVPLVNVPLGNVPLGNAPLGNAPLGNAPVGNAAAPPPAPNVVPPPFPNIPPPPMMGWGLPPPPPRPASLATLSAAELQRMEGHERRNIEARLQLLREIQAMLDASVLLMQQYSAVVANLPQNSANVATQTDNIQNEPTPGPAPVKVKTDPDVGAGVSSATPSTSSAQPTASPAHTQHTDVSSSDNTSLHVDREPKTETDADADELRRRRLQRFTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQK9</accession>
    <name>A0A194RQK9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQK9"/>
    <dbReference type="STRING" id="76193.A0A194RQK9"/>
    <dbReference type="InParanoid" id="A0A194RQK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="733" mass="84201" checksum="48B2C3C2BE19D12E" modified="2016-10-05" version="1">MDLDYKTCEVLRMLSTLSASGVFSSSVDYFCLVCESRLRDGADATAHIAKPVHTKNFLTTEYFGNQQECVRKIKKWYLCELCNVLLPTAARVRLHVVEARHAEHRVARAVQRNADRVLAFASVQLEDSAWNGILDDTCAICNTEFDDEHIHRNETSHILKLIQSKIEYDENQNLYRLVDESSFQCLTCNMVLALNSIDEHFNEIEHKERYQRCCDNFKIAENTATSHTIDSSKNTKNDNNCNEKVAIKITDRTETLDVLNSMDKNKTIIPSDEKSEIKTSTINSDVSKTEQNTTKENSKQSDPVKSVPVDDSEICKILNATDYITRDENGKTWCILCNWVMDPFAIKNHINDQHHQTILKLHKKRLSTLNSEKKLTGNTPIIKSDINTLKNTENIEKESILNAVEKFQKNNININFEIETAVCKKCSKQLDFNSQAIENHIQEHAKIKNKKNDRKGIQITSGLELTNDMKPSNKETSLYTTPVKVTKKEKQEQIKDTTDAKIKKESSPLLDYNELEKYAEQNHMTYKFDKHNENKVHCNKCNIDITPCMKLVKEHVGGVDHKKKLNEEPSQVNITSKAKQIDKEVNLLKIPTSSFVVSAVTVDSLQKEIIINEKFCINMLSFDFKVHLDVAKHDTILDRSLVVIDLENEFIREHKPGCYHCGYCNIPCQSWAAMESHLQTIDHKNCRIAAQWRLQQLLPEIARQRKEKEMQEKFMIHMMLGSGGWHGYNSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQT9</accession>
    <name>A0A194RQT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Smad nuclear interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQT9"/>
    <dbReference type="STRING" id="76193.A0A194RQT9"/>
    <dbReference type="InParanoid" id="A0A194RQT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="564"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="693" mass="82915" checksum="0B8D04668DE36B29" modified="2016-10-05" version="1">MKSKKRHYSSSEDSEESNASDKSSSSSDSESEDSSVSEHRGKKKRKRADSSESDSNSDNQKRSKKRKHKKKKKKHGKKKKRSDSADRGNVESISSLSDGEIISKKKRKQKHKHSKRAESSHSEEEQQEHRLHSVVKECRQSSDEGSQPPRTYYQKDYPMRHSASADNYERQSEVQRFYRGSSKEHQSSYQESYGYDRGHNERVYDKNRERYGHNPHYATNSEYNRRPKEFDEFKRHPRYEEHRPEEDFHRRPRDEPYQGREDSRGYNRYNNQYDHRGAHKQREVHDVRDYRERHPRYEEHRPEEDFHRRPRDEPYQGREDSRGYNRYNNQYDHRGAHKQREVHDVRDYRERRGPPDVERYREREYVEKRDKYREERYSGDRNRELRRERPPRVEKPSSPQHREHSKSRSPDRYREKSIKVESREERDGGREGRPLKERVEKRESSRGGEERRDRPRRSEERPRPAENDSRPRERKSRFADVDDKKEYGWGKTEVKKEGKPEGEKEKPNFGLSGKLTADANTVNGVVIKYAEPDDAKQPKRRWRFYPFKGDKALPILYIHRQSCFLIGRDKKVVDIALEHPSISKQHAALQYRATPFTRPDGSQGRRVRPYVIDLESANGTFVNNKKIEPRRYVELLERDVVKFGFSQREYVLLHENSKDDAQDDDNQDPPAVTTTDHIKHEKRIKEEVAADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSH8</accession>
    <name>A0A194RSH8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein FAM57B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSH8"/>
    <dbReference type="FunCoup" id="A0A194RSH8">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSH8"/>
    <dbReference type="KEGG" id="pmac:106721313"/>
    <dbReference type="InParanoid" id="A0A194RSH8"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF66">
        <property type="entry name" value="BCDNA.GH12326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="87"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="391" mass="42885" checksum="002DE5FDC7E90C2B" modified="2016-10-05" version="1">MDPPTSKARYRRAKLCVLGAVNAGTFAAAVNLVLTLDPEDRISVKRGCALTALGFVYFMSLFELFTFAALFTTSGSRLRHKYRLNCGDVLDINNKLVSAVQAALCCVTGAVVCLWSCTRDFMRSSHFMSEAYAWFGAAYFFYDIWSMYLVHVRQMGFSKSKSSNDKVKSLNEAPKNVEGSDAPKNVEGSDALTTTSLEDVGCMGPKKHKRGPKCAACGDCLGEGVNVISFFSYCRHEPVILFHHLFIGGFGFLVIVYLRGGLGDCVFGFVYLMELSTPFVSFRGILSRLGLKSSRAYLLNGLAMLATFFVCRVLSLPYVCLMYSRVIGLPYFEAIKSLPTGCKISICILLLPQLYWFYLMSAGAVKVFVGGAQSRAKSGAPLAAGDNHKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAY0</accession>
    <name>A0A0N0PAY0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAY0"/>
    <dbReference type="InParanoid" id="A0A0N0PAY0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="756" mass="86693" checksum="D8E67B547840624C" modified="2015-12-09" version="1">MELIVKAFDVNQTLTMSIKWSWVLVALAVASASGERERRGSSLRGALEALQRRQRGRSHGPIMPPPDYEDIYEYLPPHAYPENDYVLDTEDTGEENAPKYIFELLDDENERSPEGAYEYKVIKKKTHPNSLKKESAFRERTQNSDNDMLRNIFMNPNDQDDKMQDRVENDAEYALLLNQLWSKYKQNNNNMRADNTDAPQGVVKLYKEKVVKKRYPDNWGPIAFKKKRSSDIEDERLNYEENKNRANVNNNYNAYDLADNDNNDMQEEYAIAFQPIDDDRLSEILDDDQYPYDAIEKRFPVTKRSSGPYISPQQKRFALNQSKRDVPKNFRSNIGTDPKVLRDLSKIFGEPESEIIKNPVKRSSDDGETSHEIKPPNLTILSHNDTHQHNVTQDEEDSHEQHSHPIHHPGLSGKEIEHDSDRLRKQYFDTFNREVINPVSSFRKHTNVKRNFIQPKPNEETEIQIDHTQAVAVRNDNKRNTALDNDSKLDNIDRKLRNMEGLIVDEALHYSNVGEKLDSKEEQEMKEKLLSRLAAAYSLEKMRKALKEFKQSLQTQKAINMKLSTGNDETKSKRVAVKKEKAMSTTNDVANYLKDDDKIDDFQDEQGAGHYVNGKIEEQLSEGYMGGSGRHRTPIMSNVDSTGPCPVLSKIIQRCRGVDLLAGDRGQLFLTHCSLHQICYLCGEAAPTTCDLVFLSEADTTCEGDMNCQRAARSTLMALRELHDNLTDELDGECEASPCLAATLKLNNGWQRGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAY1</accession>
    <name>A0A0N0PAY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAY1"/>
    <dbReference type="STRING" id="76193.A0A0N0PAY1"/>
    <dbReference type="InParanoid" id="A0A0N0PAY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857318" evidence="2">
        <location>
            <begin position="27"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="35550" checksum="5BB2AE5AA357EE15" modified="2015-12-09" version="1">MLFWLPLFSFVLIVIIVKVYLQLTSGICRSNAHMVGKVVIITGGSSGIGLETAKNLAERGAKVIIACRSVRRAAKAIEEIIKQTGNTNVHHRQLDLSSLKSVREFCSNIYKTEKRLDVLINNAAAGGLGSGKTEDGLHKGMQVNYFGPFLLTCLLVPLLKSSAPSRIINVSSSMHKYGEMDFDNLNMERYWSDHLVYANSKLFLNLMTLELSRRLRGINVTANSLHPGVTATTVYKNIKNSIIREIVNTLVNFLNKDLWQASQTSVYLAVSPEVSNISGRYFSDCREKQPSLLSQDLELAKRLWIESENLVDYKLPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB89</accession>
    <name>A0A0N0PB89_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461098">
        <property type="protein sequence ID" value="KPJ09476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB89"/>
    <dbReference type="STRING" id="76193.A0A0N0PB89"/>
    <dbReference type="InParanoid" id="A0A0N0PB89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="64"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="436" mass="46380" checksum="47C2F5C76529661B" modified="2015-12-09" version="1">MADTLDPLSPSINSPRVPGLMHKLRMRFGRSPPPRPPGEGYVEFGEFRTEAPGVKKVGTFAGVFCPVVLSMFSALVFIRMGYLVGNAGLLVTLGQFALAYLIVIFTVTSICAISTNGAVEGGGVYFMISRTLGPEFGGAIGTLFFFANVVSSALCISACTEALVENFGANGYLVGSSGGLPTSWWFSFLYRSVLNALGLAVSLAGASLFARTSLAIWLTVLICLASAFISFFVTSPGMIERPDTNELVNTTSFHYTGLSKETLYSNIYPSYGRDYSTSTGDRVDFASVFGVLFTGVTGVMAGANMSGELKQPSRSIPAGTLWALLFTALCYTALTLLSAATCSRELLQNNYVYLLPINVWPPFIAVGMLLATFSAGLSNLIGASRVLEALAKDDIYGMLLATFSAGLSNLIGASRVLEALAKDDIYGKFINILLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC20</accession>
    <name>A0A0N0PC20_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like subfamily B member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC20"/>
    <dbReference type="FunCoup" id="A0A0N0PC20">
        <property type="interactions" value="1411"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC20"/>
    <dbReference type="KEGG" id="pmac:106713296"/>
    <dbReference type="InParanoid" id="A0A0N0PC20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000040">
        <property type="entry name" value="dnaJ homolog subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="271" mass="30779" checksum="58B1512E9662DCFB" modified="2015-12-09" version="1">MLINKVYVCLIYLISSILLTLAGRDFYQILGVSRSASTNEIKKAYRKLAKALHPDKNQDDPDASQKFQDLGAAYEALSDPEKRELYDRCGEECLKKDGMMNNNDPFASFFGDFGFHFGGEPQQHETPRGADIVMELTVSLEELYNGNFIEITRNKPVIKPASGTRKCNCRQEMVTRNLGPGRFQMMQQTVCDECPNVKLVNEERLLEIEVEVGAPDNYKTRLRGEGEPHMDGDPGDLVIVFKTERHHQFSRRGDDLYTNVTISLQVNTVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCI5</accession>
    <name>A0A0N0PCI5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="9201" checksum="B242F40D36B4F69C" modified="2015-12-09" version="1">MAGWCLVGFLVAVLGSSVLAYPRVTFPENALRSHNRIVSGWEAKEGQFPYQISLRMVNLDGRVNGCGGTIIHPEWGLTAAHCTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0N0PD00_PAPMA</name>
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        <name evidence="8" type="ORF">RR48_03177</name>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Lepidoptera</taxon>
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            <taxon>Ditrysia</taxon>
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            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KPJ15387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BESS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="352" mass="40315" checksum="A45675A40255AED6" modified="2015-12-09" version="1">MQRKCYFACEFNGPLHSFPSPSYPHEDRFNKWKSVLGPLHSFPSPSYPHEDRFNKWKSVLGEDLKNKGNDYIHKNVRLCRRHFEGHFHTSGNRLTANSIPTLNLFVNDGSITVTGLEHQTVPDVISVQIQKDTSSFSRETKKVFAKKALQAKEKWKNLRSVFVRNLKPQPKGSKKKKYYLTDAMQFVKPYIKIAGTPSSLPDPDEQGDEYNEPQDPLSPASSPSRSSTPLSDSTRRSSSDFSNQNYRRKKKKISETDELLNEFMKSKNTKKDDDEKPTINNANKMFLLSLLPDLNCMTPTQVRIFKRQVIDLMDNILTEPPNSSTLTLTLKSEHIPSTSNASSSQITRLEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDC2</accession>
    <name>A0A0N0PDC2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PDC2"/>
    <dbReference type="KEGG" id="pmac:106710864"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000153">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="37806" checksum="8004050564CF2343" modified="2015-12-09" version="1">MTQFLPPNLLALFAARDPIPYLPPAAKLPHEKKQKGYDGVGGFLEKFENYDTSESKLRREFEGYGPIKRICMVYSKENGKPRGYAFIEYEHERDMHSAYKHADGKKIDGKRVLVDVERARTVKGWLPRRLGGGLGGTRRGGADVNIKHSGREDNERERERYRLEQRDGEERAHRGERPDRERDRERVRRRSRSRSRRRSGSRPRRRERERDRERERPREEEPEKRRRRSRSRSERRRERRERSERSERSRSRERKRARRRDHKVKAEDVKVKEEPADDYPQFRLPPPDVHIKQEPAEEEDKYNPEDANGDHYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDG5</accession>
    <name>A0A0N0PDG5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0489 protein C5orf22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDG5"/>
    <dbReference type="FunCoup" id="A0A0N0PDG5">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDG5"/>
    <dbReference type="KEGG" id="pmac:106709265"/>
    <dbReference type="InParanoid" id="A0A0N0PDG5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="381" mass="43488" checksum="C759B1F8E72DBA76" modified="2015-12-09" version="1">MTDTFGNNAALKRFKKIPVYVVEEHNEALQFIYSAIGGKKLPVEGNTLVHLDAHPDMLIDRMLSGQEARAGKSVLPLLQIENWIVPAAAAGHIGRVLWLRPPWARQFTDGTRRINVGDHPMTGLLRVDSKEPYYLSDALYSSDLLNAREFTFTVAELSNVNSEHYIEEFAKNLHISEPYVLDIDLDFFSTGNPFLSLYEDIGLYDRLEPIFSFELPADDDEQTVEKVVALRERQLQELEHLFQFLEEHNTLENYDGEKTDLFRRVSNLAEVVRAEAERLSDSPDWWAVFAAGCTRDNGGLPYHISSQQEIEHYVRGTLKLFLSRLPPPTLVTVARSTDDGYCPPDQVDFIQSLVLQTLQEIYNTDDPHLYYLNVNIPNSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDH3</accession>
    <name>A0A0N0PDH3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Circadian clock-controlled protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDH3"/>
    <dbReference type="STRING" id="76193.A0A0N0PDH3"/>
    <dbReference type="InParanoid" id="A0A0N0PDH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857499" evidence="4">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="27276" checksum="6AAD2E710414079B" modified="2015-12-09" version="1">MTWQFVTQGLYLFLFSASFIKKCHFNDKELESCIRKQIENSLSRFTKGIPELGVPSIDPVQLDDINIDGNGLKLKFAEAAMHGLSNSKLTDLKVDIGSDEEDFNLGFKGNMSLTAKYNIDGKILILPIKGDGDAVVKANNVEVNIQSKLVHVKDSKGRSHLKLITPNYKYDIQSTTFDLKNLFNGNKELAETTLSFANENWRQLMDDLAPPAIKQIVRTVIKAINKFFSKIPIAQMLEGYKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDH4</accession>
    <name>A0A0N0PDH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein rolling stone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDH4"/>
    <dbReference type="FunCoup" id="A0A0N0PDH4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDH4"/>
    <dbReference type="KEGG" id="pmac:106709314"/>
    <dbReference type="InParanoid" id="A0A0N0PDH4"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF49">
        <property type="entry name" value="HEADBUTT, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31213" checksum="30702B107346543C" modified="2015-12-09" version="1">MSAIRSYFKEEGQLSMLGLECSKPSCFYLSAWQRNRSTTPLLVWRSLLFLTSLGILLSSMIMYGLKGKLGFWFIYLTHWGLTLNTVATAMSAAVSARCYFYGPIGAEFALPWYVKSYWVFYNSAVPIAFLITVFYWTILYEAGFEEELNHGLDVAVHGLNSLVMFLLLVSASQPSRLLHVCQPVIFGLTYAVFGAVYYFAGGVDTNGNTWIYPVINWAQPGSTMAMVAITGLLLVVLHLAVVGMANIRDAITARVIRRSIITHIEEGIPLRTATNQQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDR7</accession>
    <name>A0A0N0PDR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460126">
        <property type="protein sequence ID" value="KPJ17597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDR7"/>
    <dbReference type="InParanoid" id="A0A0N0PDR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857426" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="120" mass="13205" checksum="805519DA187591BD" modified="2015-12-09" version="1">MAVKIIVLLALLAIVDAQENCGCDNGQILQEASDTFKFLKTLSPKVGEEYPIMPGLLSPLVSCDCGGNRKKRKTLPDTMNIVKEIRPTPKYEDHAAAGIRNKCPLGFRRIGFMCLNVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEH5</accession>
    <name>A0A0N0PEH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TD and POZ domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEH5"/>
    <dbReference type="STRING" id="76193.A0A0N0PEH5"/>
    <dbReference type="InParanoid" id="A0A0N0PEH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="331" mass="38101" checksum="CAEA9B6716146374" modified="2015-12-09" version="1">MENGDVSPLNNCQTKEARRLYIYDIGTKLNTPGQYDIGGTYTEDESDLWFFCSTSLCPGYQYLLNVFVCHRKPGIISVGISTSDVLTYKVNIGTVTNNVLPDSLSWQTLRAVEADEINHIKTFCFTEMDMVRMKYETLIVPLSIEWEPKCFVSDSVIKRVKLKHNFGELLTNESSKDFELKTPSGKVYKIHKLILAAQSPVLRKTLKNLNEKSLLLDICDNDLELLLQFFYTGTINNVSEQNCIQLLEMAGRFELRSLFLFMQDVVKKQITVENAMDIAIISEKYKLEDMQKNIFQFIKEHPQVLNTESWKKLNDINLTKKLLENIYKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEU2</accession>
    <name>A0A0N0PEU2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459795">
        <property type="protein sequence ID" value="KPJ19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEU2"/>
    <dbReference type="KEGG" id="pmac:106712628"/>
    <dbReference type="InParanoid" id="A0A0N0PEU2"/>
    <dbReference type="OrthoDB" id="7411278at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015318">
        <property type="entry name" value="Znf_GAGA-bd_fac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09237">
        <property type="entry name" value="GAGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="261" mass="29716" checksum="87771CF126023C04" modified="2015-12-09" version="1">MSTIQDSAWSKISGETLNPKEKCLNITEEIYKRINITFQIKKLETGSQSDISDCSDQIDSNELSNETDLFACDKSSLSSSTDQERAISKCEKYININNNEETKLNKPAPVYKRPRKRFRKRVKKHQSNKTRSDSDCSSDEAIPLSRVDIDTRNSQSESPDSVMGVPNIIIVAKESKQKPKSTQKNQQKQDKPSNSVSEDSPIKMKTSQKPISDKSQQWKHCPICSLSFRGERGLRRHMTMSHIESNDIKDTNEIEKDVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFC6</accession>
    <name>A0A0N0PFC6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01020461">
        <property type="protein sequence ID" value="KPJ21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFC6"/>
    <dbReference type="STRING" id="76193.A0A0N0PFC6"/>
    <dbReference type="InParanoid" id="A0A0N0PFC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="82" mass="9193" checksum="0E287E50AFDECF24" modified="2015-12-09" version="1" fragment="single">LFNSRSPSFCDADPRMDSSGTSGRVCRIGRTSRTGSCDLLCCGRGHALIRRSSIKPCNCTFHWCCRVDCEKCHDDKWVAMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFG1</accession>
    <name>A0A0N0PFG1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01000549">
        <property type="protein sequence ID" value="KPJ20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFG1"/>
    <dbReference type="STRING" id="76193.A0A0N0PFG1"/>
    <dbReference type="InParanoid" id="A0A0N0PFG1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9991" checksum="5CF0DBA4516ADEB4" modified="2015-12-09" version="1">MPPVQMLNCKKPIKVNKHFFQHGRVEPSSNEVELAVQWAIEAGYRHIDTAWAYKIEDQVGRGLANKFPDVPRNEIFVTTKVSDKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I549</accession>
    <name>A0A0N1I549_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I549"/>
    <dbReference type="InParanoid" id="A0A0N1I549"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137640" checksum="D7D1550E29517E2B" modified="2015-12-09" version="1">MKDLPSCLLKRYRALDEVIRDLRSVAESRPSNSNCECGCKSDHGLKLMCEFWNMLQDNPNCNPKAASFDQKCSDKLKELMETEQQLKDAIKKLEAREKESIRMLKEADCMWMSMEDTYKKKMAETFERQKLLEKELRGVATSAKKWRENMKELEGKIEKVDKYRCDVRDKTSQKSNDIKYFDTEIKDLQHRLENNKKEIEATKKSIVTKKEATDKKIAKYREDIKSLEKVVAEENKTKKEKELQGSKIIKEAREDLQKICGILLKKKLENEDLRAELSSAIPHSNQYMRAALSSEIELLLQARDKCRDKCDLRQKSIENQIQNLDKQINDQQTKCSKCNQCTDTVEINRFCSDCPKCLEERRCALLGDHCGIDHTMDCICTTVKRKFLDNVFENMYTVLERQIKKGGGKAVADQILECLKRSRNGKLDDKTRKMLQEFILTAVKKYLNLTIVGGAVKTRCELDPDMYKQLMTCLQKVQVSKPEKVDKGTVSKKAPCNRWGGTSECYCPKGPKDCICTKKAPPPPHDPSPCPVDDDYEDDDKKLCPYKEKMICGPECGKEDEKFRQMMNEITKSRCDTCSGSTCKMSKNMRTATCVLKPDLSSTIPTRDSSLPKSKLKQHLTDQGYCDCFYPATNSKYDQDAKQLNKRQRDAQTTCPITICLNDCFLNIVKTPSGASVLEFDKDLVKALENESKMHPPSSMNLIITDSGQILIEFKSEFQNSYIDRMMKLKKVLPGCLFFKGNKNVSELFQRTLDNMSEVSSNLYKKVGQMQPNAVLRKTSSGIVLIIATEPLDQVHNTLLALLPETYTKLKVLQNDDSIYDFPGVLKSTPSRNYVLAIDKEFEKCLKATVKNVIKDDSTAILTLRKSESGSHVVKFGCCNTEPQTEIGILQKTRSGNIKIISNVFRDLSLAKKVISESEEAMKLSKCCKELILNLPKTKYYQVTMHQTDQLYNIYENRLPSSNKAEKLTKQNQVGKSLGQIPLNKDFKANFIDNIKSFLDSSKSLPIKSTVSDSIILFVRRRCSKAPILLKFTRSSNIYVSKIKKRPIKDVAAVNSSHLHNMIQNRRMENKLVGTKSIVQHKNDSCDLLEFDSNEVSRLIQSETIGTMKSSSKDIVTIRGKRNSIKSDKTKPHIVIKPTPGMSCVYHNSDYNELSELGSRNIFDEENKEEASSSGNDENKKHHWDSLRFLPPQLPSFLGEVVHMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I833</accession>
    <name>A0A0N1I833_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KQ460880">
        <property type="protein sequence ID" value="KPJ11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I833"/>
    <dbReference type="FunCoup" id="A0A0N1I833">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I833"/>
    <dbReference type="InParanoid" id="A0A0N1I833"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="158"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="448" mass="50505" checksum="F9B2811D9A6EC239" modified="2015-12-09" version="1">MVVDLIRNIRFTRTDVTAVKLYEEYVIAGIGSSLFIYKKDTLEVVTIHHKILDGQKIYGIEFSKDGSKLLIFGDQRITVFKAKENENDLEFVKQIMTDVSDVQGLDLIEYTENTITICIFGKGLEVLTIQLEERQLVQNTSNTSMAPQVTAVTEPVTLGEGPHWDHREQALYFVSIFDRSIHKYVPATKKHTRSVLDDLVGFIVPIEGKPNHFVVGLKRRIAEVIWDGQDGTAKVIRTIAEIDKHNPENRLNDGKADPRGRLFAGTMGYEYEPGKFYHKKGALYRFDPDGKVHTLAENIDISNGLCWDVEEKAFYYADSFEYAIRRYDYDIETGDISNPKFVFNYKDHGLEGIVDGMTIDTEGNLWVANFDGHQVLKIDPKKGKLLQKIRIPALQVTSATFGGPNLDILYVTSACMNRGVEQKPPCGSTFQLSGLGVKGHPNANARFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8V9</accession>
    <name>A0A0N1I8V9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8V9"/>
    <dbReference type="InParanoid" id="A0A0N1I8V9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12900" checksum="07B6B96FB1FD8831" modified="2015-12-09" version="1">MTQKMVCWPLAKNMAAVDDNVKILPTMCLRVCEFWTWRLMSIYIACVGIFVAFIFGPLQTVVYLTDQHSEMSRLINTEINLALMLWFIVAFIDGTPFAITPEGGKLFFLEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICF5</accession>
    <name>A0A0N1ICF5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICF5"/>
    <dbReference type="InParanoid" id="A0A0N1ICF5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7481" checksum="58380A37DB6FCA3C" modified="2015-12-09" version="1">MRRDLRVVRAFKSTLEDLEERLSAHSAAGLRSRLRAPPQDIAYIDADDVPNAATAPNATAARTETTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID25</accession>
    <name>A0A0N1ID25_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KQ460864">
        <property type="protein sequence ID" value="KPJ11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID25"/>
    <dbReference type="FunCoup" id="A0A0N1ID25">
        <property type="interactions" value="1409"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ID25"/>
    <dbReference type="InParanoid" id="A0A0N1ID25"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="39416" checksum="14EF8EF3AF9A3012" modified="2015-12-09" version="1">MSSQEQEVLFETLNNAGVITLNRPKALNSLNTNMVTMMLPQLQDWERSKGLVIIKGAGEKAFCAGGDVKSAIDRVEGPKFFHTEYNVNYLIGKYKIPYIAFMDGITMGGGLGVSVHGRYRIATEKTLIAMPETKIGLFPDVGGSYFLPRLQVNLGLYLGLTGDRLKAKDVVKSGIATHFVPSRRLFELEKLLSRCNNDSEIRNLLNKFNEPPEEFSLAPNIKHINYCFAASTIEEIIERLQKVQNDWSVKTLKTLSQMCPGSLKITLRALQRGAQLDLPQCLRMEYRLACRATENHDFPEGVRALLIDKDNNPQWNPKTLDEVTEDYVESYFKKLPEDRELKYFDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDV4</accession>
    <name>A0A0N1IDV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00032</name>
        <name evidence="1" type="ORF">RR48_00033</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01010926">
        <property type="protein sequence ID" value="KPJ20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LADJ01057871">
        <property type="protein sequence ID" value="KPJ21586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDV4"/>
    <dbReference type="InParanoid" id="A0A0N1IDV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7525" checksum="78B46C9767B4F7CC" modified="2015-12-09" version="1">MGLPRYCSASGMFAEARTDGFDAIMRKRCASLLRRMRDSHNVILNALLDRWDSVMLARWINIHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEB5</accession>
    <name>A0A0N1IEB5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01031091">
        <property type="protein sequence ID" value="KPJ21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEB5"/>
    <dbReference type="STRING" id="76193.A0A0N1IEB5"/>
    <dbReference type="InParanoid" id="A0A0N1IEB5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="260" mass="30043" checksum="7625339A8D58C1D7" modified="2015-12-09" version="1">MYSEMLSEGGQQLLIKFVLKGRLTQSAKLRVESTYKTVSDMITDFRKKLLVKKSFTAIQKHIESISQGHKSINEYGSELEKLLTDLNISQADGNEYASTILKPINEKMVIKKFTDGLRSEKLSTIIAARNYSSLQDAIQAAKDESVPSSSAEVFRMTSTHRGRNNFSKYHRKGQSFQNFPENSYNNGRYSNHFTSKPPQSNFRGRFQNFRGNFNHYNKNVRYNHIKRNSYLVQNNNDQIQNSDRSGQKPPELDKKQFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEI8</accession>
    <name>A0A0N1IEI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle glycoprotein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEI8"/>
    <dbReference type="STRING" id="76193.A0A0N1IEI8"/>
    <dbReference type="KEGG" id="pmac:106711825"/>
    <dbReference type="InParanoid" id="A0A0N1IEI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF38">
        <property type="entry name" value="SYNAPTIC VESICLE 2-RELATED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="553" mass="59523" checksum="95F4658646B5869F" modified="2015-12-09" version="1">MHSSPYEFFYGYGRFSRSVLGACACAFFTTGVQNCVMSYVLPAAKCELRLTTYQAGLVNMAFMCGGVASAFFWGIVADVFGRRTILSATLLIDSVILLAQSTVSDYRILLAARTVNGFLIGGPSTIVFTYLSDLVGVKRRQLYLNITGMSFVAAWLILPAVAWLVIPFKLESHSQLPIHSWRLYLALGSIPGFLAGMWVLLLPESPRLLCDTNRSEMALKLLAKIHRCNMGFAGEFKVKKLITDNIFVAKTVNGEENRTKVLFIGVLKDLKMFVSKAYAFKSTLILFVFFANMAAGFGLNLWIPELLLRMQGKECAFARSIPETAKLFNASNVAWKDLSKAHDHNSEIDRFNGTLFNAYEAVGSSVRCDENIDSAVFTSGLIVGVCCVLGNAACAVLSGRGGARGVQRAAAACTLACALACACLAACACSCATSSKVAVAAAAALNAASLNGNVLLIRLLLHALPAKLSGLGVCWGAWWGRAGGVVSNLAVGVLLDYSCPAPFISVAGLLTISIGAIMMIKLDEHNNNESVEDKTEQESEKYTGLDRYISTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEW0</accession>
    <name>A0A0N1IEW0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEW0"/>
    <dbReference type="KEGG" id="pmac:106711103"/>
    <dbReference type="InParanoid" id="A0A0N1IEW0"/>
    <dbReference type="OrthoDB" id="417175at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="26249" checksum="9D24808943B5BBB7" modified="2015-12-09" version="1">MISEFANEKVFWTRKMNLKLVYFIKNNPNVWNPKHPKYTSVEHKDQTYAEFAALYGNKFSGQAVKNRWTNIRSTFANYLRKFKASRANGEEEYKINWHLWGPCQFLMKVNRTVKDSSLNLNESDEKNSSLIHNQYNSNDNIIDDTNTNSHCKAIAENLVKIFKKMQNDPFGLDKTQYGEVGQTVSKRLSEMDSYDAAKAVVKITEILLLYDKQNLLNPNNFKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF15</accession>
    <name>A0A0N1IF15_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03486</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IF15"/>
    <dbReference type="InParanoid" id="A0A0N1IF15"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="703"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="843"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="956"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="1344"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ07773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1398" mass="158482" checksum="630034A46E540877" modified="2015-12-09" version="1">MSSQASNSKYNTIIAPLNDNLKGPTLQDTFSLFKTPLQIPSLEEIKQGITDIIDAGQKESQDFQQTDFDPLNESSNRNSVLSNPLQLNFPKSNYLGKPLTDRYLRPFQNARNNIAGYKSILDTTSLKPLITEPFDYPSMLRGYPSSLASDRSNFAGNKNLKASSDATRISSLDDITRFFQNQNLLKPTNINLPKTNLLKSPSFNPQRINSLADDLKYRLDSLKPDFKQANHGNQLLGKPRSEKDDLLLTMSKKHEDMKQKLQALHFDFNDRLASMYKRLNDQKKIQSVNIPTFKTKDNILGLPKTASNKERTGQNLNSNSLAKLDNSFLSQPQLLQDHTSMKKKLTPKPKSIYKVKASTGPLKEKENGHISKYPNLSENHKLNMNKQKTFTPVSKVKISFNTTPKPFSSSSSNLQKSQDPIKIPSRLSESERTADLNSNLKDISKAFRSRFQPFIDLNHSPSELIETKHLNADLSNSEPRINSKQANSDFAQNLKQMQDTKKTESPLISNLREALKARLQNITNTHAKPFRSPVESTNLREDDAVVLPSNVKTSVLKKSKYEYELDTGTKYQTIEGFGTAATGSAGYNLNTLPAAAQDNLIRSYFSDEGLEYNMLRVPIGGCDFSLTEYAYNDLPVDDCRLTNYSLTCEDLNYKIPAIKKMMEVSKSPVHIVASTWSPPKWMKYFNERSPNCGFLKTEYFQTYADYHLKDHPKVLDYIDGLALHWYYDNDVPVQTLQKFQQNYPYLFTLSTEACEGYQSYAKNKVDLGSWERAENYIKDIFQNLNNNVVGWLDWNFCLDTNGGPNCMNNFVDSPIIVNSEKREFVKQPMFYAMGHFSKFIPRGSRRIRVKANCSPKCIDEAAFITPQNTIVFVVYNDSSKATRISVNVGEREIPLKLEAKSITTVEFNNEDCQCKSNTTSITVHASSNPVVLKLKAARKVCIDVLKVNPTKTHQKIQGFGGGITDSAGINLFSLPPNMQQDIINSYYSERGIEYNMGRVPIGGCDFSTHLYAYNEYPINDTYLTNYTLSYEDYNYKIPIIQAIMNVSTAPLQLVGTVWSPPGWMKDNYGDSGVNRLKDEYMGTYALYFLKFLQLYKENKIPFWAITTTNEPLNGVIPLGEFQHLGWTVKRMGEWIKNDLGPMLRNSSFKDVKILAVDDQRYSIPMWFNVLLQLVPEAEEYIDGVAVHYYLDNITPASILQETVKSYPKKFVISTEACTGFTGPTDQRVVLGAWDRAETYIIDILENLLNNGVGWIDWNICLDMIGGPNWVQNYVDSPIIVNAEKKEFYKQPMFYALGQVTKFVKRHSHRIEMTNVTVCPNSKDTDEASENVFICNSDGNDPVYNSAAFLTPENTIVVIIYNRGDAKNVVISARDKEAVVELEASSITTVEFQNEDVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF51</accession>
    <name>A0A0N1IF51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase [NADP+] A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460773">
        <property type="protein sequence ID" value="KPJ12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF51"/>
    <dbReference type="STRING" id="76193.A0A0N1IF51"/>
    <dbReference type="KEGG" id="pmac:106713649"/>
    <dbReference type="InParanoid" id="A0A0N1IF51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="21373" checksum="9873D61EDEA08174" modified="2015-12-09" version="1">MVPTIPTVRLNSGYEMPVVGLGTYARKADPGQFCKAVEWALETGYRHIDTASVYNNEEEVGEGINNKIKQGVVKREDLFVTTKLWNDKHAEKDVVPALKESLERLKLDYVDLYLIHWPVSVNKNGEDEDIDHSETWRGMERIVELGLARTIGVSNFNEQQLSKLIEMAKIKPAVNQFEVNFAFIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II06</accession>
    <name>A0A0N1II06_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING finger protein 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II06"/>
    <dbReference type="STRING" id="76193.A0A0N1II06"/>
    <dbReference type="InParanoid" id="A0A0N1II06"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16472">
        <property type="entry name" value="RING-H2_RNF38-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000024">
        <property type="entry name" value="RING finger protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF3">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="34182" checksum="598BE506B617CF77" modified="2015-12-09" version="1">MGGVYAGLPYHGGFPPPPPRAPFASPPHAHYIAGSQRAEGGRLEVVGGGEGGLSPLQPAPDLHHAPHGPLLLTAEARGAPLELMAPHHARHALSHHHRRSSVGVGSGVGGVGVVGAGSRAARPYVRAAARWPPHPVHHIHAQSGGGLLGATLPHPQLQVTPTLSLPPPPPTYQVTSHCARRSPPSAGVTTRRVGQVFLNLLAMFPLSPYGEAREEAAESEPENYEALLSLAERLGEAKPRGLARHEIDQLPTYKYSEQTRHGEQTSCVVCMCEFEARQTLRVLPCAHEFHAKCVDKWLRSNRTCPICRGNASEYFNNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INB2</accession>
    <name>A0A0N1INB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INB2"/>
    <dbReference type="STRING" id="76193.A0A0N1INB2"/>
    <dbReference type="InParanoid" id="A0A0N1INB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="93" mass="10938" checksum="DA65A3FE21E0F479" modified="2015-12-09" version="1">MDGIANSCPNLERLELRWDPENLRFSDKSQKAIDILRVKCLKLKCLVLSDGRYYEIVKANFERADRLTVVRTSTNCRVSNYYLLSNYKDLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPF4</accession>
    <name>A0A0N1IPF4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPF4"/>
    <dbReference type="STRING" id="76193.A0A0N1IPF4"/>
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        <property type="term" value="C:phagophore assembly site membrane"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
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        <property type="entry name" value="Atg1-like"/>
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    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="155"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="766"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="827" mass="95300" checksum="EFC1313D982760F8" modified="2015-12-09" version="1">MAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGEILLRYRFAQHMTEEQLRCLRGSPLYMAPEMLRGRYDARVDLWSVGVIMYECLFGRAPYSSATFKELVDKIQRQAPIELPPRSSISPGCQDLLSRLLQHDPDKRISYEEFFAHEYLDLEHMPSKENYEKVSVIMYECLFGRAPYSSATFKELVDKIQRQAPIELPPRSSISPGCQDLLSRLLQHDPDKRISYEEFFAHEYLDLEHMPSKENYEKAVGLIKRAIELDSAGELAGALSAYSDSLLYLVPAVAAESDALRRSALTAKLTSDSLLYLVPAVAAESDALRRSALTAKLTSWRARSPPTATVCSIWCPPSPQRVTRSAAARSPQNSPGQLAGAPSAYSDSLLYLVPAVAAESDALRRSALTAKLTRYMERAEEIKRYLKGESNRQVQCTPEQQRYVSGQVEVAPNVQDTTSCVQETIKEQETEEQNKNEACPERAKRPGALARLLRRSQVPQLLRGDASVTDEQIDKPQKNEDGNDGCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPI3</accession>
    <name>A0A0N1IPI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead box protein J3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460480">
        <property type="protein sequence ID" value="KPJ14357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N1IPI3"/>
    <dbReference type="KEGG" id="pmac:106711589"/>
    <dbReference type="InParanoid" id="A0A0N1IPI3"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="305" mass="33891" checksum="53C641EFB6C35363" modified="2015-12-09" version="1">MSESPGVEWLPAYSPGPPRHSPLGPIPRFLYEDVQPPCLQQENNNKEVDLKENLNKIKHTKPAYSYASMIRLAISSSPNGKMTLNEIYNYICNAFPYYKEAGKGWMNSIRHNLSLNKCFMKVPRSKDDPGKGSYWAMDTSYKMAEVTPRRRRSLRMAPYSPECSSNSSGEAGMLPCAIDAAPTPPATPTTPTSPTVTAVTTVKEEPVVKEEYDISHTDDALSALMNEELMPDVDISRERWWWSGGRRHVCGALRHSSLTDDYGNFVEVRDDCDCPVDCEDTPLSPLATPPAPLATPPAALWPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPM6</accession>
    <name>A0A0N1IPM6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPM6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPM6"/>
    <dbReference type="InParanoid" id="A0A0N1IPM6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="19858" checksum="EAE0DBA88EDD206A" modified="2015-12-09" version="1">MMQMGQKRGEKPPKLPPRENGYGPADIPKPDYDDIEVNGRVPSQFPRGKSDKGKDNKKYDDPYYCGLRARVPNFVKANGKHVLPTMTERLTLKEAPVPSKRYSVAHAHPGPFLPHMPPFAHAPMPPAALWHARSYESGIDGEHYDPYALYGRLPVPGRGFPPPPAPHARQMFIGEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPX7</accession>
    <name>A0A0N1IPX7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPX7"/>
    <dbReference type="FunCoup" id="A0A0N1IPX7">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPX7"/>
    <dbReference type="KEGG" id="pmac:106720831"/>
    <dbReference type="InParanoid" id="A0A0N1IPX7"/>
    <dbReference type="OMA" id="AHCKKGQ"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000184">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="17038" checksum="1EB0E10E70553275" modified="2015-12-09" version="1">MAAVQETRREPIQAVQVFGRKKTATAVAYCKRGHGVLRVNGRPLDLVEPRLLQYKLQEPILLLGKERFAGVDIRVTVKGGGHVAQVYAIRQAISKALIAFFQKYVDEASKKEIKDILVQYDRSLLVADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ95</accession>
    <name>A0A0N1IQ95_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459687">
        <property type="protein sequence ID" value="KPJ20456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ95"/>
    <dbReference type="KEGG" id="pmac:106720600"/>
    <dbReference type="InParanoid" id="A0A0N1IQ95"/>
    <dbReference type="OrthoDB" id="6776666at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="408" mass="47568" checksum="DB8A117E0F7A3AD8" modified="2015-12-09" version="1">MTSHRIEVCHSADLKKLLLEAGVVCARTVAESEDTSLSSEETVKDVPGLEIEAEHEETVVHEEPTYPIEEIIEELPEIFPTPSLRKILPDKIRMIEKHNRIHVLPEVFNTDIDPMKIPRISSTHAQKYINDLAEITGCKNYMNSLAEFWFLDTLANLLRRAQEDGFEKSSQVVLIQWFCEWMKEIQHFDAATRQRMLKRFKDTMLLAAGHLAQYDELPVPADVGVSYKPEETVNASLPPMATASKHLVTFENFQCCLTDLTKMIHYIFDLFSSDFQYDLIRSVFTFTPEYRIIDVPHTLQQPKRFYTTYKPKSKEKAPKKEKEQKTAKGKKKEVESEQFLHLVQLQNEIEREKEEEFEKEREDWHRRSHLLPLSFAVTDEFFDKYWPPPTPEIVSIPETEPKGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG92</accession>
    <name>A0A0N1PG92_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG92"/>
    <dbReference type="InParanoid" id="A0A0N1PG92"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="412" mass="46787" checksum="54602E9B72DCD478" modified="2015-12-09" version="1">MADKGFVSQHFNIDPSILLSLYSLRSVGTYESARILAMFPTPSISHQVVFRPLTQELAKRGHEVIVITPDPAYPKGQAPKNLTEIDVHDISYSKFKILMERIKDVARDVIKQVEVIIDSNNAVFEEQMKTESVQEILKYKDDYFDLILVEACMRPAIGLSYVFKAPIIQDLKSYLDSSKNGVIYFSLGTNVKPSNLPSDKLQVIINVFSRLPYDVLWKWDDEELPGRTKNIKISKWLPQSDLLRHPSIKLFVTQGGLQSTDEAITAGVPVIGIPMLGDQWFNAEKYVHFNIGHKLDIDTLTEEQFDNAIKSILNNNSYRENIVRLRSIMQDQPQSPLDRAVWWTEHVLRHGGARHLRGPAANISWAQYLELELVLTLAAILISSLIILFIVAKLIWNVLKVQLSAVIKVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH75</accession>
    <name>A0A0N1PH75_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH75"/>
    <dbReference type="FunCoup" id="A0A0N1PH75">
        <property type="interactions" value="1166"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH75"/>
    <dbReference type="KEGG" id="pmac:106711667"/>
    <dbReference type="InParanoid" id="A0A0N1PH75"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="215" mass="24417" checksum="5AD8614C23E9E13E" modified="2015-12-09" version="1">MFVLSEMKDVIRVTPEHFHQSLTESITTLLNRKLANKVVLNVGLCIALFDITHIGHSYIFPGDGSSHTEVKFRYIVFRPIVEEILIGKIRSCSRDGVHVTIGFFEDILIPVNALQHPSRFDETDQAWVWEYPKGEGEKHDLFMDSGESIRFRVTSEVFEESLPTGPLGTECPVQTIAPYRIIGGINEPGLGLLTWWEAQEQDDEADENDDQENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHA1</accession>
    <name>A0A0N1PHA1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone deacetylase 11</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_05762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with HDAC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHA1"/>
    <dbReference type="FunCoup" id="A0A0N1PHA1">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHA1"/>
    <dbReference type="InParanoid" id="A0A0N1PHA1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000009">
        <property type="entry name" value="Histone deacetylase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="31089" checksum="53B179C83475231A" modified="2015-12-09" version="1" fragment="single">LYFDIRDDQWPLVYDEKYNVSVLGLEKLHIFDAKKWGNIIQHLLRAKLITKDCLVHPNEAKKEDLLVVHTKKYLQSLKWSPRVAVIAEVPAVACLPNILVQYAYLKPMRLQTGGSVLAGKLALERGWAINVGGGFHHCSSDKGGGFCPYADITLLVRFLVDNEMIQNAMIVDLDAHQGNGYQRDFLGVPEVYIMDMYNKHIYPKDKEAKRAIRRKVELDHLVEDTEYLLKLHKHLKAALDDFKPDILVYNAGTDILDSDPLGHLSITEEVNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIH5</accession>
    <name>A0A0N1PIH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSCD family member AGAP003962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460773">
        <property type="protein sequence ID" value="KPJ12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIH5"/>
    <dbReference type="STRING" id="76193.A0A0N1PIH5"/>
    <dbReference type="KEGG" id="pmac:106713650"/>
    <dbReference type="InParanoid" id="A0A0N1PIH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="19814" checksum="893150F3A284299E" modified="2015-12-09" version="1">MIKTLRKSILFLAATVALYFSITLIVLSNNEKQYSNDKINTGYSSIDWCKKLHWRTPPLPFAIALASYPGSGNTWLRYLLQQVTGIVTGSVSLDYSLRKKGFPAENISDGSVLVVKTHKYPPKNLNKFESAVLLIRNPRDAILAEFNRINSGHTGIAPKSAFEMKVRAPKRKGYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK89</accession>
    <name>A0A194QK89_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK89"/>
    <dbReference type="FunCoup" id="A0A194QK89">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QK89"/>
    <dbReference type="InParanoid" id="A0A194QK89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ05988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="39886" checksum="565728DE334C7895" modified="2016-10-05" version="1">METAVEIFHFVSEKLGIQWAPRGVPMTRRLQTLGAAGWICLVLFGEAITVLVYLSILYSSMWWLALAYAVWMLKDVETPNKGGRRFEWVRNWSWWRNYCDYFPIKLIKTSELDPSKNYLFACFPHGVVSSGAFGAFATNALNFYKTFPGMTCHMITLGGHFLVPLFRDLILALGGCSSSEESILHLLDRRKHTGKCVALVVGGAAEALDSHPGEYSVILSRRKGFIRVAMKTGAPIVPVFSFGEPDVFRPFNNPRDSRLRRFQEKVRQWTGISPILPIGRGIFQYTFGVFPLRSPITIVVGTPMEVERNLEPTDEEVDAVHAEFTRRLIELFESEKSKYLKDYENKTLVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL24</accession>
    <name>A0A194QL24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative odorant receptor 67d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL24"/>
    <dbReference type="STRING" id="76193.A0A194QL24"/>
    <dbReference type="InParanoid" id="A0A194QL24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="53868" checksum="DDE291C4802611D4" modified="2016-10-05" version="1" fragment="single">PFWIFLLSCSFYLDIVGFVTFHIFYADGLIDMLNSYFNISLFVFIYNTGRWMIFERKGLRKVLKLAERNNNMAMQFENITPKHTALMKSMKKLVIICYFFHFVNDFIVFTPQRVSKIEDFSVTSCVATFWALHFVLLLYIYGFGCLFYQIKFANGPGDFIKSYVNVSIFTLTATSSGWFLMKWPFCKNVLKNVIKNDELTRQSAFLKKRHSNLLSAIKKMLLVFYISNMINVFFIYLPSRADLQNDNYSMTQCVGLEPLSTSPNREICQTIILTLELSLVTIVLNYQGLLLLLISHTTAMYQLMADEMTALNENDNENVKERLPIMIVRHSMTMGTVDDLKKLYSVPIGIHFGSNAVCICLFFYLPLQDWITFIPVLMYCFLVYFLYCFLCQRLINASEVFERAVYCCGWETFDLNEMKLTYMMLMQAQKPIELLAAGIVPVNIYTFATSMQAMFKFVTVVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLC4</accession>
    <name>A0A194QLC4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLC4"/>
    <dbReference type="STRING" id="76193.A0A194QLC4"/>
    <dbReference type="InParanoid" id="A0A194QLC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13342" checksum="2D1ED1399EF0E13E" modified="2016-10-05" version="1">MAEDIFAQDERERESLRRMLYDTLCFVYLRLDQAAVPLRCNRPQDFAYGLTAKCKSERTCKRYLYSGCGGNQNNFQTRDECFKTCLIPPSNSLKEISTFTTCIPVNYIPAIFPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLF9</accession>
    <name>A0A194QLF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLF9"/>
    <dbReference type="InParanoid" id="A0A194QLF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="851" mass="94231" checksum="C65B984C0BD4DC5F" modified="2016-10-05" version="1">MSFDDRIVSRVKEMCAVCTRQLTAHRVHNIQFSAPWFVGGICVKVPVSPLFWIAANFTFVMLTESKRLPVKCGDSRILQECKHERPLEAFSAPKCEESDAPDSEGKLSTESSPLRRRRGGILKGGRLWKSLDADKDFNEQNDDQRSTTTTASDEDGSVTPRSVRFVERPKESNEEEPISQVEPESAQDSDDETPIQKDTTANPTHRLETPLILTIQTPKTNSAVQQLFNSNRPPPPAIEPQLITSETLRLETPLILTIQTPKTNSAVQQLFNSNRPPPPAIEPQLITSETLRAWDAGVRPKAEDVAVRRVAERNALRCSLLRSEARKKQQAKQETTSLAERIRLLTCDVEDESTEDRASPAAVSVDKLSSSSDKSSDKSFTMDKNSEKAFGSASSSSSSSTLSAPMLVRQHPPDLGDVHQEQPKPRPEPRRQFLSTLAPLTACVGSAAHHEGFYYVAPGDRTSASVPTNIDYKDHNDAPAPDVVAGTPGANDGDDGLAAFARASAPRTERIRQRYGQDSHPVSSDDEHDDYGFHRRPAVRGIAVKQQLGTSNDMLQQMQNELQPTSSTAATHHQPHACQRTSSTYSWPYYSEANLNSRPQSRTSTNTNWMKPTDYVSSRQCSNAAMPQQQHSEMCHAHTQNMVPPYPQYQQRQPETMFRNCSLYANIGCSDSSQELYSSQTSSEQTSPVRAASRCRRPESPPPIRSHHQLLYVPYSSHQHYQPEYPTHCPPNDYNRQVQSYYQQQARSGASTPQPNVALQQRAHYSHALQLQNLCPAPARYRPVPAPQPGGGKQMICYSEKVAPPLYQPAPGSPSRVPRTAPEGAASSSQAPSATSPLAQPPNPVYYAMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLI7</accession>
    <name>A0A194QLI7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QLI7">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLI7"/>
    <dbReference type="InParanoid" id="A0A194QLI7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19815">
        <property type="entry name" value="Bbox1_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047543">
        <property type="entry name" value="Bbox1_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047542">
        <property type="entry name" value="Rcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032065">
        <property type="entry name" value="RNF31-UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041031">
        <property type="entry name" value="RNF31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LUBEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18091">
        <property type="entry name" value="E3_UbLigase_RBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16678">
        <property type="entry name" value="UBA_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1839"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1843"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1212"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1549"/>
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        <location>
            <begin position="1673"/>
            <end position="1765"/>
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    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1344"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="425"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="542"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="570"/>
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            <begin position="618"/>
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            <begin position="657"/>
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        </location>
    </feature>
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            <begin position="706"/>
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            <begin position="724"/>
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            <begin position="1157"/>
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        </location>
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            <begin position="1239"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1704"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2237" mass="248078" checksum="78B5A086362A3293" modified="2016-10-05" version="1">MLKGRGRDPRAAVPPTPTMSIRSVGRPPLARPEPDYEVVEFPAEQYVNAKLQPPPPPPPRPQTGHPTEAGASCGLCGGGGARVRCAECGRRALCASCDDMYHRHPKRRHHQRQALSQSQLLDERPPLPPKTGPPVPPPRKHKISGDRLSASPRLPTPDQRRATLTSISTNDVPVLHGPAAANPNHFTARAQTHLPAPPPPHLGSMPYLSGTMQHAQTPVAPTHEQSNTLGHVPNAWGRQRTSLPGFVPPNMVQPMPVGTWDNSNGPNPTQSWGRPLRRGTSVMELGVGPQGGPAGPSCAGCPHCLAQPWRYGSCASLDHAWAGHAAWPHNYCPPTHQPHNTVHPAYPHAHQHPPQTPQPYRRAESRAVSRAGSRAGSRAPSPAMSVRSRASRRPKHRTPSPPPLPSSDADSESESESDHGPAKEQESEEDLLGPPPSPPSATWQCEHCTFVNEPGVRVCVVCCRTPTISPRIINPATIQNDIKKLKISGDRSTSVVGSNGDGSISKHVTAKEKTKTKKERTSTACGPSPPREDRATRKAVSQVATPARETSSAAPARARHDMAVGPSPPKETQTIPNLTQTATIRPSPMRSSTPREYKTEKHSVSVGPSPPRDIKAPTQQNLSQNSTSNQKKSTGTSPPRETRLDTPSSLLSSTSSRANVSNTGTSPPPQSISTQTYEVPSGREWERAPSVSVSSARRRERSVRTSGGGGGGGGGGGTLGPGRWEWRDREREPRDSSPGGEWSGSERRRSTRLTRRASHLDLRRTRPSRPSRRSSIYGSEAPSPEPFTGNRAVSLEALAGAGARRETERGLELARLMGEAEKLGFSAAEVHAALAQNPAAPIAWLRERWPSLCAGVRAAAVRLAPGAVISERDARTALARHRGAMWPAVTDCVEKWRRQTESLGLGSEGRLRGHVWGSPTGVEDDAAPPMDRSHRIRAEESSDEYEISPAVIQDDDWMYLPLENVNNSYYENYPTNEQIDSPNPETEDIALKLKSLLIQAGIPNINEQLLLKGLLANQRNTEMDTNSNTQNTDSNVKQNSNDFVQSENDFIDAYNALTRLSPLPNISKPNEIAHTEQESNDNKDSETVLKEQVNTHDSNKNNKPRKNTNSIPSEQNLKTTQKHPQTQQLTKDNQNESVEKIPQHKHVTKVNLQPKAKTSKSPKRTTAKQNQRIKKKLESSDSETYEDEEKRNNLSDMVDNTQRIIQQMKKELNSDMNSLDSRSNSRSENDISSNDSESSSEKESSYNERSESESEDISSDDSEGVTSKTENNSMVKATTVTRTSSEDNEQFEEAIDHLEIEIENTIPQIDNLENPHLDFQQRNIEILDSIAKSLQEEYSSVQDQQINMPRNDHQDFNNNLFNTVNSFEEIYEQLTESNNSTNSNTEQPTKSIEIDNAAHYSVIQKSNYNKQEVKFVTFNPQTANAYLLSDNNVTLHNAIIEDINNEIEINVYDSLNSTVASEILDSNEYQSEDNSMGPNEPKDNNIIINHNSKEHETFTENVMNSRTSVDNTYISTPSDNNSTHTENIEKIEDYELELNSNIKEKNETEVTDKITKKDSKLDDSENTTVNNKNIPNTNPSKDGTRVKTNSSSNKGIFNRSNIPKLVKALQNNKLKVEKTTPKVLGSKVPVRRTSIKHYPAPAPPNGHFGNVQNGNVKQLQTKLFNNKVQNSTNMSTEVEVKPSTSATSTLSKKKPAPLPPTTNHVERKLETPTEEVQDKEKEHYFRETCRTEDEWTDSDAEEPQIPVSKENNEPEAVPVSPPPPITMRRVSGQLVDLATIRLPEGSPERQARMLLAEGATENWEQAQLAVELIKRGINPPSALLAALECVDLDSALAYLQQDCELCASRLPEYEMVSMLRCTHRCCRECARHYFTVQITERSIADCVCPYCKEPELENLPEDAWLEYFAHLDILLKTLLNTDVHELFQRKLRDRTLARDPNFKWCVECSSGFFVHPKQKKLRCPECRSVSCASCRKPWSSNHEGLTCEQYTKWLDDNDPERSVAAVQQHLRENGLECPRCHFKYSLSRGGCMHFTCTQCKYEFCYGCGKPFMMGARCGLSEYCAKLGLHAHHPRNCLFYLRDKEPHELQTLLQMNNVTYETEPGPGSTGRCPVQLQRETPTGLVDGACGSESSPNNAGLCKRVYEEEGAAVSFGCACRNHYLEYLSRLVRSREVDPLPILGVDDLETLVRRAALRLPPRPYGTLEGLYKRGLIEVCLRPLYLQDALRGVPGGAGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM34</accession>
    <name>A0A194QM34_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MKI67 FHA domain-interacting nucleolar phosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM34"/>
    <dbReference type="STRING" id="76193.A0A194QM34"/>
    <dbReference type="KEGG" id="pmac:106720217"/>
    <dbReference type="InParanoid" id="A0A194QM34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
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            <begin position="313"/>
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        </location>
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            <begin position="343"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="55114" checksum="8F99B0EAB76A5641" modified="2016-10-05" version="1">MEEHVALDSKKQKKFVKSLKGIKKLMKETGALPEKPQKQKKHEETGKIKKKRRPRRGLVYLSHIPHGFYEHQMTDYFKQFGVVTNARVIRSKRTGRSKGHAFVEFRDMTVAQVVAETMNNYLMGKRLIKAVYIPPKDQRVHARRKNWNLQNNPGRKMKLKMKKAYNSKKSENEDMKIARKLFTNLTNTKNKLKDLGIDYDFFTPVDVPEGLMEQLEVKKEHEDKKDIVDEKPNKKKENKKKDLKNESDDKNKTTDIVHTKQEKLTTKEKKQKKGNKDLESNEKNAVVAVNNKNNKQVNGTEKISAKDKKNKKDNKETTVLETIKKDKLKEAGVKPLEDYISIVDEEDDDSDSSYQFDSDEYDNELNADDSDTDASSEDDEDNNDNDESNEDDDNEESDEDIDDSDSKEIPLQRINKEAKKSKVPTKASKPKVKQVPFMQQMKRKVAEKATVPSKKPKFEKQNNKKLPSKQLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMU4</accession>
    <name>A0A194QMU4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein heavy chain 2, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_11357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QMU4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMU4"/>
    <dbReference type="InParanoid" id="A0A194QMU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000008">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="350"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="957"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1783"/>
            <end position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2981" mass="341295" checksum="AF940F5D6F84BAD4" modified="2016-10-05" version="1">MLKKGDIEKCHFVPLSSLERVIDMVENYNPEHDHRCQRNLLQLQLEGGSTENNFRQRKWRHKLHAAMSRAIYAHDWEKLLYLLKKSPIWEHDTNRLDQLPIYTRAMTILLMYHPYAKAQSLLSEYFHMNAVGLPIAKAMISEDGETIEWKHSVLLDGPAEMWLLGLEHMMRVVLREQLIQTRLALRKCRYQREQWINDWPGQLGITCSKIQWTSDCTRTLCRCEIMKEKKPMKKLRKKQNQILTTLQNMSRKEITKILRCKVNALCVIEIHSRDCVDKLYKMGCMSVTAFEWFSQLKFYWDREREDCYIRQTNTSFIYTYEYIGNSGRLVITPLTDRCYITLTTALHLYRGGSPQGPAGTGKTETTKDLGRALARWVVVTNCSDGLDYKSMAKCFAGIAQSGCWGCFDEFNRINIEVLSVVAQQILAVLQALSLQQKRFLFEGFDLKLDANCGIFITMNPGYAGRTELPDNLKSMFRPIAMCVPDSLIIAENTLFSDGFTAYKINAKKVFTLYQLAMQQLSKQDHYDFGLRSMVALLRYAGVKRRAYSNLPEQEIVILAMRDMNVARLTAKDVPLFNGIMQDIFPDVEVPTLDYEMLETAISAEMRLIGLQPVKAALLKVIQTYETKNSRHSSILLGDTNTAKSVSWKMLAATMTRLKREGVPGFEIVQVYPMNPKALTLGELYGEYNLATGEWKDGVLSAIMRTVCQDESPEQKWIVFDGPVDAIWIENLNSVMDDNKLLTLVNSERISMPPQVSLLIETLDLSVASPATVSRNGMVYNDYRDWGWGPYVNSWLDTVDDIDYRDMLRRHFQNILSPVLALKRTVGEGLRGHELSGVRALCRLLARTPPPPHPTEEDDDTFAKMRFLFALIWSVCATLDEDARRRLDNWIREHEGVFPLKDTVYDYYLDERLRQFRPWEDRLPDNWRFNPALGFHSILVPTVEFIRVQIISLELLKGGHGVLVAGPTGTGKTYLIQGTLSQLDPEKYSNQVINMSAQTTAANVQDMIEARLEKRTKGNYVPAGGKKMIAFMDDINMPVKDDYGSQPPLELVRLWLDYGYWFDRQKQWRKNVKDMVLCGAAGPPGGARSHLPPRLLSCFHAFFLPSPTHQQLIKIFGTMLAQHLMEFDEETKTVGKIVLVATIDMFNNIVAKLLPTPSKMHYLFNLRDISKIFQGLLRSNKDYTNTKPRFLRLWIHECFRVFGDRLTEEKDRDWFMNQVAEMLGKHFELTFHAVCPTKSPPLFGHFLNPFEVYDDMNDPEILRKYIANQLEEYNSSPGVVKMDLVLFKDAIEHVCRITRVISQPRGNMLCVGIGGSGRQSLTRLASYICESNSFQVVVTKTYGVKDFREDLKTLYTSCGVDAKQTTFIFNDTQIVEESFTEIMNNLLSSGEITNLYKPDEFEDIKQALEKAMKNANIMQTAESVYLFLVDRVRSNLRIVLCFSPIGEEFRNRIRQYPALINATTTNWFLEWPREALLEVAYKFLAGVELLASITGQRVRRKESVVESREEILRASVASIMSLVHSSVGRHSVRMWNEMRRVNHVTPTNYLELVSGYKEMLKNKRAEVALQANKLRNGLGKVEETTKLVGQMSEELAVAKVQVAEYTEQCVEYMGVINAQQRNADEQQRSVAARSKKTQEEEVQCKRLADAAMRDLASAMPALEEAVKALDALNKKDITEVKSYAKPPQKVEMVMEAVLILLQKEPTWAEAKRQLGDQYFLDRLRDFDKDNISDKTLKKIGTYTAKPDFEPEIVGTVSLAAKSLCLWVRAIEKYGKVYKIVKPKKERLEEALESLRMKQQILAEARAKLRELSEMIARLQKEYDEKLAQKEELERKSRMLQLKLERAEALITGLSGERERWEMTVERLDKEFDNLPGDCLIATAFVAYLGPFVSEYREELMDDWFREVYNEAVPVTMDLSMKNFLLDDATLRDWNYMGLPDDNFSAENGIIVRRATRWPLAVDPQGQALIWISRLEENNGIEVVDFGQPNYLKVMEKCLSEGIPILIQNVGEVLDPSIAPILDKAIVKIGSSMVIKFNEKMVPYNSNFQLYLTTKLGNPIYTPEILTKTTMVNFAVKEQGLTSQLLGIVVRKERPQLEQMKDTLVLSIARDKKVLVDLENDLLRIMYESQVPLLENEELFQTLQISQRTSLQVKEALITSQVTEKEIDTAREGYVPVAVRASVLFFALNDLSRIDPMYQFSLDAYTDLFMYSIDRSQKSSELEDRINYLNEFHTYAVYKNTCRALFERHKLLLSFHMASRILFQAGKLNMNEYLYLLKGGIVLDRSEQPDNPTNWIPDECWDNITELDKIAGFHGIIDSFETMSKEWRDWYLTPEPETQPLIGEWNEICSEFQRMLVVRALRADRVGACAAAFVLRALGPRYIEPPVLHIRAAWEESSWKTSLLFVLSPGVDPTSSLIQLAMDVKMFDKFQSLSLGQGQAPAAERMLVQGMEEGGWVFLANCHLACEWLGSLRGLDNPTIHHRFRLWLSSMPDPKFPLGMLQRSIKMTTEPPQGLKGNLVRIFANLNEDKFDEATPKYRKLLFCVAFFHCTLIARKRFRQLGYNDVYSFNDADFEVSDNLLANYLEEYDEVPWAALRYLLAVINYGGHITDDWDKRVLLAYINQFFCEEAHDVPFYRLSSMPAYHVPRDGSLESYRDFLELLPTAERADSLGQHSSADVAALAQDASIMCSTLFLLTSSGSGGAAGGEDQKVDELAAEMLVRLPGKIDMETTEKLMGPEIVMPMCVSLLQEIGYYNVLINYIVSGLKELRRAIEGLVVMSEILETMYRCIFEGKVPTFWQKGRPTLKPLGSWCRELWARGDRLGAWAAAPRSPPPLCWLPALLAPTGFLTAVMQTTARGEGWPIDTLCWDFTVLTIEEQNIMRAPRDGGVYIRGLFLEGASWFKKDAHLQDPLPMQLVFPMPPIHFKPVRATGRRPKNRYTCPCYYYPLRKGAFVVAVELASGREHPDFWVKRGAALLCTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN52</accession>
    <name>A0A194QN52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family G member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN52"/>
    <dbReference type="InParanoid" id="A0A194QN52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF105">
        <property type="entry name" value="FI02074P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="9">
        <location>
            <begin position="230"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="51952" checksum="B94DF154F89C5CFB" modified="2016-10-05" version="1">MHDDILQPRLTTLESMRIAAELKLGPEIKKANKKVIVTEILQTLGLWRQRHTMCERLSGGQAKRLAIALELVNNPPVIFLDEPTSGLDVVSVRQLLLLLRLLSRQGRTIICTIHQPSASIFNLFDNAYVICGGQCCYQGAPSQLVPFLAEAQYICPPSHNPADFVIETLAAEITARNKMSDLCQNGKICRWSKDMSVQLSDLEESENNKCMEQVNKDKSLNLEFPTSFCTQFLILIKRLYIQSKRKQLNWFIQLMQYILCGLFIGGIFYMVGNEGSTPMANFKCYICITVFIIYTYTMVPILLLPMEIRIIRREYFNRWYGLKAYYAALTCSTILPANGAILGPSIISPLLVLCCYGMGFGRHIEPGMRFLMHLSYLRYGLTGMTLPLYQNRTRMHCSEDACVYGDPIYVLQELGMDEDTYIIQILGLSVFIVLFRAIAYFTLRHRLANEYSNSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP33</accession>
    <name>A0A194QP33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate sulfotransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QP33">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QP33"/>
    <dbReference type="InParanoid" id="A0A194QP33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="311" mass="36266" checksum="F57DF94387E44D26" modified="2016-10-05" version="1">MLRRVNFYSICIAFGLSVLLILAGSRYTDNTNYRPSSENRRNIKNIQKVEDGEELLQPLPTNPDDGSPDIEKIIEKTRCNFDGMEDYFEYGKGHLHQFSHNGRLWDHCKYKKELCFDSEFTARFCKQFPFQSMKVVRVRLRLIQEILQDKELNVKVILLIRDPRGVMQSRQHRNFCQPAPDCWQPELLCADMISDYVAAGRLXVLRYEDLALNPNATTYKLFKFLGLSVTPSVTEFLRSHTSVEVAGVSSTFRVSRDVPFRWKNVLKYDYVEDIQITCKEAMSLWGYKMAHNASHMLSKDFYPIESYSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPH1</accession>
    <name>A0A194QPH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Viral cathepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPH1"/>
    <dbReference type="InParanoid" id="A0A194QPH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264533" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="17522" checksum="3239F71EB116EDEE" modified="2016-10-05" version="1">MAGIKYGFILIFTFVITSRALDKPWYDLRNSEELFKKFQYDYNRHYETEDDRERHYEWFISNIVRINYLNSKEDTAVYGITIFADHPVVDAKLMLGYITDNDDELWLPVATYRVIPALRLATAAAFETFVSDVLIDILQQRFGTRFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ55</accession>
    <name>A0A194QQ55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194QQ55"/>
    <dbReference type="InParanoid" id="A0A194QQ55"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:collagen binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:extracellular matrix binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF29">
        <property type="entry name" value="FOLLISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="357"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="434"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="511"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="583"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="663"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="730"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="798" mass="87154" checksum="B72BB42FDDA091ED" modified="2016-10-05" version="1">MNRPGYDYTVPATNTYYASNNRPPQYERGYGQLTAVPLYSPTSHPLSNYADVYEGNNDTTLRAEERHWYIENHKNLQPNYDINNDPIPQEAKIKKEEEKKADIQPVRRTDGTQARQRRKEDRCSCECWPTSDNNAVQDSAGNETTRSLSGVDIVASYGVYGNPQDEDSSGFARLSEKNAAFGQRSDAPVQGVIVNQQGNSAVIRSTPSSDSACGKCCVWSSNENPSNSEDYCWIHYCRPALIVLLLLFFLVLLGVSTGFLLTNNYLHYQPRPPAPEEACEKTFCRWGAECVSLGDGRAHCACPVSCPATQVPVCSTAGRTYRNHCFLRKEACERRLNLRVKHEGECAGDPCSTVTCPLGARCTVTYGQAECRCPRSCQRRKPVCGSDGREYPSSCHLDKHACDNQLNITIRYHGKCDPCEDHECADGGICQLNESRTPVCRCGPACELAPRPGAALCGSDYKDYPNECALRRESCRTRQQLSIAYRGECASAQHPCESVKCGVRERCLLDAHGVAVCACGAPCEDFVRPVCGTDGRTYDNPCSLDRTSCLENRDIRVAYMGPCGVENPCARASCPWGGACVSRSGAAQCSCPVCDASLAPVCASDHNTYGSECKMRMHACQANIKEQDLQVLYNGTCQTCADILCHGGGDCVLDTDTGRPVCRCNHNCTEALESEVVCGTDGQTYMSQCELDSTACREQSDLRLAYRGDCALCDGVQCSFGAHCVAGECVCPTDCTDAPREPVCGSTMQTYPNECELQKAACGLLPPTTLHVIFYGDCKDRLAVVPPIAMSAYIVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ79</accession>
    <name>A0A194QQ79_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SREK1IP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible splicing regulator involved in the control of cellular survival.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ79"/>
    <dbReference type="STRING" id="76193.A0A194QQ79"/>
    <dbReference type="KEGG" id="pmac:106718795"/>
    <dbReference type="InParanoid" id="A0A194QQ79"/>
    <dbReference type="OMA" id="KHHKKRQ"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437:SF1">
        <property type="entry name" value="PROTEIN SREK1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437">
        <property type="entry name" value="SREK1IP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="16339" checksum="78978C1C376F3FE6" modified="2016-10-05" version="1">MSNYNDLVNKFGKDSTRAACKKCGYAGHLTFQCRNFIKVDPNKEIVLDVSSTSTDSEEDYATPLQTLREAELKKKLEQLKNIKKKTKKRKRSSSTSSSSTDTSSTDSSDSERHSKKKKSKEKKKSKEKKKKSKKSKKHKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQB9</accession>
    <name>A0A194QQB9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQB9"/>
    <dbReference type="InParanoid" id="A0A194QQB9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="47741" checksum="9EFEAD97B05D56A7" modified="2016-10-05" version="1">MIIDAYEIYGHDPTDKLDFLVHYQIEMMKIKRARDQYLINEHIHIATDHLGRFITLHIKELKVLLIALEDAIDNMLTMYDNHNAIKSERVATYNTGSGGAVPTEFYLSQEFYCGKNVYLFVSELYSDIYNMGRGPAPYCKSRGFHFLGFVHYMDENRYFLEEDPNIVFQMDNYIHGLECHLGMCIFRFPFKKNLQHVRDVSTLPKAIVKCGTDMYKLPPLTAASCIITSGSFILDFNIQGIRFRHYDYLLIMPNGHTYYTKEKFSPLVCDHHVCEWNNTNFYGGPFIIPGDPGTGLSPIPPFIEQTTEYFQQTTTTPNEFNPNITYTLDGCWFMFPPNYGSIGGISYLDPLSINEYRYTCQGVGNNKGLYWYPQWMGAPPHHPYPQSDDAPADIPQGIAGSYYPHLQHVPPNIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQJ3</accession>
    <name>A0A194QQJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Semaphorin-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQJ3"/>
    <dbReference type="STRING" id="76193.A0A194QQJ3"/>
    <dbReference type="KEGG" id="pmac:106718778"/>
    <dbReference type="InParanoid" id="A0A194QQJ3"/>
    <dbReference type="OMA" id="PHIPRDG"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11237">
        <property type="entry name" value="Sema_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000346">
        <property type="entry name" value="Sema-1a, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042068">
        <property type="entry name" value="SEM1A_sema_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF131">
        <property type="entry name" value="MIP07328P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264555" evidence="9">
        <location>
            <begin position="18"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="10">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="737" mass="82243" checksum="E0D1D92714798ADF" modified="2016-10-05" version="1">MAVARAVLVLLASTAHAWMPDANARIHVKYGEETSEQFVGNSTAPDHFRILDKDDFSIIVGGRNAVYNLSLYDLSENVDQRLEWQSTDAHRELCQLKGKSADECQNYPRVVARSHGRLLVCGTNAFKPLCRRYDTSRQNHRLEEFDGSGRCPYDPEHNSTSLFTDGQLYTATAADFSGTDPLIYREPVKTERSDLRILNDPSFVGAIASTSHAYFFYRETAVEYMNCGKAVYSRVARVCLNDKGGPHTFSERWTSFLKTRLNCSVPGEYPFYFDEIQATTELINGIYGSGNTRNDIIYAVFTTPQNAIGGSAVCAFAMRDILDAFDGPFKGQESMNSNWLPLEKEKVPHPRPGTCVEDSRTLPDSGVNFIKTHPLMEKAVPSFLARPILIRVSLQYRFSSIAIHPQVQAMNGNKYDVMYIGTDDGRVIKAVNVAANDGSFDASVDENSRNPVRTAVISEVQVLPSGVPIKQMHVALTTEKLIVASGDIIKGVSLSHCTNVLSCRECVALQDPHCAWDSKQQQCSWVGNRQFPNPERFLQNVEYGKTEVCNKLPALLPERRNKQPADTVAHDDVRNEILIEVVETNVVSEDKATNNHKHETDLLTVEAADGNIYSAQALLTAVVASCLVTLMLGFVIGYLFSRRFRHPFFADTSPFNEQHNHLNRLSPLETPLNVNSGYMPPRSKNVNMVANVGPLVKQDNLHLELGKDRSLDMRNSTESLDKDLKCGTLQKVKKTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRE6</accession>
    <name>A0A194QRE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 21-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRE6"/>
    <dbReference type="STRING" id="76193.A0A194QRE6"/>
    <dbReference type="KEGG" id="pmac:106718392"/>
    <dbReference type="InParanoid" id="A0A194QRE6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="205"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="838" mass="90337" checksum="025EA6241B816237" modified="2016-10-05" version="1">MPSIDNDHETSSRSVLTAMDSGQAMTLWYTDILSPGGASGAVAAESGSRDALDVRYSLAALADDYTKRKHVVRVTTAAGAELLLQADGAADAQRWLEALRRHSAEPPPAEPAPAAPAADNTTEPTTTPAPAPASAQPDCPSPLPPQRSKKITRNRSPTGPPTPTLPSSPKNKTWKGRMAKQLRRMQGGAGAGAGGAPAVTGWLGAPLERCPTDPDHPGVPLAVTLPATAVEAYGLRTVGVYRVPGNAGGVAALAAALDRGCAPAGDPRWADVHVASSLLKAYLRRLPDPLLTHHLYPAFIAADRSPERGRELRRLVHALPAAHYATLRYLVQHLRRVAAHSASNKMEPRNLAIVFGPTLVRAASDDMLAMVNDMSSQCRIIESFLIHYSWYFEESSGEPPAELQGGDAPQPSRDLLIHNVKKIEGKDVSTRDIVSSIISAANRKIQRKPRTKPAAADKKWAGSDKSPPSSPPHHATSLAHYDGLHHSHHSRHSTDKIEIESGGARHTLNTFSIDGPGDLVSSLTSTFDQKLRTLNNSSPLDDGSIPYADECQDDAEGEDKSSDSSPSLGRERASPAPSPAASPAARAHELKAAWLARDLRHSSSSSNEDEARHWPRRDRSEKPLDNDDSEKENCLGPRRPLDDDKDVDTRSQASSADTAPDNDKRLPYYAPIRLANTDSGKRNSAALALDGEATTAPDGDDECAKLKRSESLSREQERGEARVLRSESLNCRADRLQRSDSLSKADRPSKLEKCEWNVARRREAGAWRSTKLKRKNGMPERGIKRRHTVGGTKDFDKDGWGARHTRTSSPDLSAPAPSPAPWPAALVPPPRPPLESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS99</accession>
    <name>A0A194QS99_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS99"/>
    <dbReference type="FunCoup" id="A0A194QS99">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QS99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264591" description="TIL domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9828" checksum="BA8D5F67D82F916F" modified="2016-10-05" version="1">MKSILSLLIVCLLFANSSQFLQKLFCSGSHEKWIPCKSDCIKDTCAYVGRPVSCLKVIPCAPGCVCEIGFARKNESGPCKPTLTVEFPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT25</accession>
    <name>A0A194QT25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gastrulation defective protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT25"/>
    <dbReference type="FunCoup" id="A0A194QT25">
        <property type="interactions" value="2065"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT25"/>
    <dbReference type="KEGG" id="pmac:106717768"/>
    <dbReference type="InParanoid" id="A0A194QT25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001228">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="597" mass="66806" checksum="C8C2C31CBDD208A4" modified="2016-10-05" version="1">MNKKPISFGKISLNINKPAKDDASTSGFGTFGRIPIQEQKEIEEIADDLENQHVHQIMGIKNFGKKAKNFNVEEMMEQAKKTAQEVTKNKIDAETNKEVSNNSESEDDSYIGPPVPPGLQDDSEELIGPPIPKEVLEGNTKSTSKVKSTSKGNESNSEEDSYDELSGSDDDDVSLEKKIPNTHEVEMLHGSKAVVALAVDPSGARLATGSVDYDVAFWDFAGKTKGHTASLNSGCWHPHIREEFMTCSQDGTLRLWLTENPKQHKSVIKPRQQGGLRTNPTACTFSRDGNTVACGCFDGSIQMWDHRRNFVNTTALLRDAHQKQTEISSICYSYLGTQLASRGNDDTLKLWDLRNFKKPLNVFNDLFSRYEQTDCGFSPDDSLIFTGESLQRNQDVGRLLFYDTKTYKHVTSIEVSKSHVIKSIWHAKLNQIFVGCGNGTIKCYYDQKRSLRGAKLCIVKTHRKKSSVGIVSTQQIITPHALPLFRQEKLRTSKKRMEKDRLDPVKSRRPDLPITSGQGGRVAASGSTLSSFVIRNLGLSKRVDDEQDPREAILKYAKEAEENPFWVAPAYKKTQPQPIFQNENEEGPTDPKKQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT77</accession>
    <name>A0A194QT77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT77"/>
    <dbReference type="STRING" id="76193.A0A194QT77"/>
    <dbReference type="InParanoid" id="A0A194QT77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26826" checksum="1029B431EB337AF9" modified="2016-10-05" version="1">MESIPTEPSTTLFFAYGSHMLTVRNELDNIRAEFVSIARLDVCYFAICIFLQICFIYLQINLHLFKKIIYRITDWISSGIQSFGAGRKLQWCPQQMLRNKQVHLKRYYIIHTEVNTPHMGKLVCRVYIQKINPLPRGDNDDIPVEQWPSRTYKKVMILGAIEHNLPYYYIRNLKKLKHNGELGCYRMAKLLKLFTTRYPCTCRLYDPRRPRILDMKKLREKMKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV43</accession>
    <name>A0A194QV43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Venom carboxylesterase-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV43"/>
    <dbReference type="InParanoid" id="A0A194QV43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264656" evidence="3">
        <location>
            <begin position="18"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="644" mass="71404" checksum="DA9234B5CECE7B47" modified="2016-10-05" version="1">MAVALSVFSLCILGALAQTPQLRMVTIAQGTVVGSVAADGNYYEFHGIPYADSTSGSNRFKAPSPPPSFQSMFIANRKGVKCVRALGVGYEGTEDCLVADIYTPTLNNTDRLPVMVWIKGKEFDKIYEHDLSFTNFMERDVIIVSLNYRESILGFLCLGNEAAPGNAGLKDIVAGLRWVKQNIAQFGGDPDNISLFGHGSGAAAVDLVSLSPFADGLISKVISQSGTALSPWAVTRDNLKYAIEVAEALGHTINSIHDVTDAFKRTSVAALMAVINELDLTDNSLAFAPCLEREDIENVEPFLTKSPYTILTEGTYSRIPFMTGFVDYEGTIRAEEAFEDNWLQKMEESFDEFVQPDLKLEDNEDGLQTIQDIRSFYFRDNIINETQINSFLSYHGDTMILVSAIREASLRASSNSSVYLYQFSYKGMLGDPFVGPIEVNRAAHSEELAYLFYHESESQPSEMDLAVSDILVERWTNFAKTGTPESELSQVVWKPFTNSNSNYLRFLDDEEVNENQGGSLEVDLQNPHIETLLFWEQIYSKHFVDAKGRWDLADRGEDDDSDVIIDNGSGEEGSGEEGSGDEEGSGMSIQIERVLRVRRACRSRLARAMWPTSCLLPPFALAPCSGYSPDELQSTEKRRFTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVI3</accession>
    <name>A0A194QVI3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVI3"/>
    <dbReference type="FunCoup" id="A0A194QVI3">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVI3"/>
    <dbReference type="KEGG" id="pmac:106716747"/>
    <dbReference type="InParanoid" id="A0A194QVI3"/>
    <dbReference type="OMA" id="LCENPTR"/>
    <dbReference type="OrthoDB" id="5399166at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017246">
        <property type="entry name" value="Snapin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305:SF2">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="146" mass="16315" checksum="2427500C41C9C62A" modified="2016-10-05" version="1">MDDTESTTTSADENTGNLCDNPTRDTLAEGLLGLLKPTVDQLDDRVRATRISQLELKQQIDSLNEELLKVRESLNNHPDLDPYVKKLITCKHKVTVVLNILQASQDRLNQIRRMVEKDKPKVKVISEPLPEPEQGTSGVSDKGSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWF1</accession>
    <name>A0A194QWF1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWF1"/>
    <dbReference type="STRING" id="76193.A0A194QWF1"/>
    <dbReference type="InParanoid" id="A0A194QWF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="11166" checksum="B032E7773A27A3C6" modified="2016-10-05" version="1">MSNFDDILFELTPPELSIIAQNASENILPEKSKIRYIPTYNEFIARREKKKANRFSENVMLAYFSELSAKLKPSTLWSRFSMIKSMLKITNDVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXX0</accession>
    <name>A0A194QXX0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LIM/homeobox protein Awh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08982</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXX0"/>
    <dbReference type="FunCoup" id="A0A194QXX0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXX0"/>
    <dbReference type="InParanoid" id="A0A194QXX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09373">
        <property type="entry name" value="LIM1_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09379">
        <property type="entry name" value="LIM2_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000023">
        <property type="entry name" value="LIM homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="32560" checksum="FC6F2F3885CEB843" modified="2016-10-05" version="1">MDGYVAHKADLRRGFCTPTEHHTCCACGEAIADRFLLEVGGGTWHTGCLRCCVCAVQLDRHPSCFLRDRQVYCKQDYVKTFGAKCSKCCRGISSSDWVRKAREQIYHLACFACDACGRQLSTGEQFALHEDRVLCKPHYLETLDGGSISSDDGCDSEGYHKSKAKRVRTTFTEEQLQVLQANFQLDSNPDGQDLERIAQVTGLSKRVTQVWFQNSRARQKKHQHTGKGKQNQLMSRDADPAGFGRPINLHLTYSFQNKPPFVPIDGTSFTDSSMDELSEDSSIHCMQSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYL0</accession>
    <name>A0A194QYL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenosine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYL0"/>
    <dbReference type="STRING" id="76193.A0A194QYL0"/>
    <dbReference type="InParanoid" id="A0A194QYL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="18536" checksum="89EF567E477E7165" modified="2016-10-05" version="1">MLQLQRHFADAGISDKSNAFFDEFQIGAGDTRNLSENSSENLNIISAFIISINRSNGISEAEDIANLAIEYHKKFPDVVVGLELSGNPALGKFEDFISIFTKARNAGLKISLHCGEISNPEEIIQMLQFKPDRIGHGTCIHPNYGGTDETWEALCTSKIPVGMFRKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZR5</accession>
    <name>A0A194QZR5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZR5"/>
    <dbReference type="FunCoup" id="A0A194QZR5">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZR5"/>
    <dbReference type="InParanoid" id="A0A194QZR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054167">
        <property type="entry name" value="Tor_FN3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054166">
        <property type="entry name" value="Tor_FN3_3nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF620">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TORSO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23008">
        <property type="entry name" value="FN3_Tor_3rd"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23006">
        <property type="entry name" value="Tor_FN3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="582"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="897"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ10470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="945" mass="106324" checksum="E0BFC0A20B224D27" modified="2016-10-05" version="1">MSMGSRILVKSGPYRKPTTSLPPSLTIRCQSAESVTFMRSSNQGLQLVVLVPLEEDFERAVTFTILESADTIGQLNTTPSRNYTLWTTLLDKDGSPMLWLRGPDVYVWTSPAHVNYDVKTEMLLRHYKNGTRHIPAEFTWNAIDESDSCFYVVNKCNKDTQGDFFTDSIPAKRSFEAHVCAHYRPTSFQPDSNRSVLIERLPLDDVCVFMLTGKYGQTLVKYRTPQCYDIRGCVPLPEQFSNVSMKVADVYGKWRVRVSWKRPRVTPIYYNASLYADTTYNVIVPGNATEVIFEDVSGEGKYTVSLAATTAGGTARTSRTGYFPILEKISNLSMEIGEAKGGGWRVRMRWARPRSTPMQYNATLYADTVYNMVLPGNYTEVVFDDVYGEGLFNVSLMSTTTAGTVYISSEGYFPSEKSSNMTVKVSEDENGGWRVWARWPRPPAQPIQYNATLYADTVYTVNLPGNSTEVTFDEIYSEGSYNVTLVSITSSGEQFYASHQGNLPRLSHTLSVGLLVGAAWLTALVFVIAVSMLVYLKKKSSEKDKFEYFQGLKDKLYKESALEAVSEPVVSEDRWEVSVSRLALHELVGEGAFGRVCRATLAPATEVAVKMLKEFPTPDEVRSFRAEMELMKSVGSHPHIVSLLGCCSGRRPLIVVEYCSRGDLLTFLRNSWDVMITKRNARYYNTKDNLEYGMSLFKIDEHEQSKAIVNKLYDLQDVCDELTFLDLLSFCRQIAMGMEFLASNRVVHRDLAARNVLVTSEKTLKVADFGLSRDIYQENLYKQKGNGKLPVKWMALESLTHRIFTTHSDVWSFGVVMWEVVSVGGAPYPAVAAARLPRLLRTGYRMPRPANCTPQLYEVMMSCWRVRPNERPTFAQLRARLDALLSAAASDHYLVLDVPTDPPPSPAPTPSALLNGKEKRQRVHNYERTSALSNHYTSTPVTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0D1</accession>
    <name>A0A194R0D1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_14887</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0D1"/>
    <dbReference type="FunCoup" id="A0A194R0D1">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0D1"/>
    <dbReference type="KEGG" id="pmac:106714813"/>
    <dbReference type="InParanoid" id="A0A194R0D1"/>
    <dbReference type="OMA" id="QYENYVC"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16634">
        <property type="entry name" value="mRING-HC-C3HC3D_Nrdp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000268">
        <property type="entry name" value="E3 ubiquitin-protein ligase NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="NRDP1 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="316" mass="35867" checksum="DB07CCA193C4081A" modified="2016-10-05" version="1">MGFDIKRFQGDVDEELICPICSGVLEDPLQAPACEHAFCRACITEWISRQPTCPVDRQAVTASQLRPVPRILRNLLSRLCTSCDNAPHGCNAVLKLDSLASHLVDCEFNPKRLMPCEAGCGLVIPKDELAEHNCVRELRVLIASQQGKLTDYQQELTEQRLIINEHKRELALLKEFMRAMRVSNPAMRALADQMEREEVVRWASSLARARVTRWGGMISTPDDVLQVMMIKRSLSESGCPSHIIDDLMENCHERRWPPGLSSLETRQNNRRLYEKYVCKRVPGKQAVLVLQCDNTHVDEHMMVEPGLVMIFAHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0H0</accession>
    <name>A0A194R0H0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0H0"/>
    <dbReference type="InParanoid" id="A0A194R0H0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="185" mass="20213" checksum="21E55F9BEE3047CD" modified="2016-10-05" version="1">MNRYNLAKRNISVKKKPKVAPRARKSASYGTRRQAAVDDQVVGRGCGRERRGQGLPEAAATLFPPQLGCVPYVTPCACCPPYILQPAPHPHPLPLPLPLPLPLAYPLQALEPQAKRRPQLSNMVSTTAMFPADSATCSRSSDNFLGQRARLQLLTNKCDNSSRERATATDTIATSIRQAQKACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R146</accession>
    <name>A0A194R146_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Carboxypeptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_15066</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R146"/>
    <dbReference type="FunCoup" id="A0A194R146">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R146"/>
    <dbReference type="InParanoid" id="A0A194R146"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF93">
        <property type="entry name" value="CARBOXYPEPTIDASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="395"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="849" mass="96620" checksum="25661FAF128287CD" modified="2016-10-05" version="1">MKETTFIPNVLIVVPSFNKSYESYDLITHKYIGPSNHNQPLYLDMWSSFTKEFYKNNNLFPHDMSDMYGKVVKVACFTYKPYVLLDLNSTLVPFGRDGMEIRIIEEFCRWINCSVEIVRDDEYQWGEIYKNMTGVGVLGSLVEDRVDLGITALYSWYEEYLALDFSAPCIRTGITCIAPAPRLLASWETPFLPFTLYIWIAIFFTFIYASIALTFAQGGSTKNVFLTTFGMMITQSQSDVGRSWRIRSITGWLLMTGLVLDNAYGGGLASTFTVPKYEKSIDTIQDIVDKRMEWGATHDAWIFSLALSQEPLIRQLVNQFKTYSFEELERKSFSRSMAFSIEKLPAGYYAIGEYITDKAVLDFTIMLEDFYYEQCVVMLRKSSAYTNKMNELIGRLHESGLLLAWETQVALQHLNYQVQLEVKLSRSKKDVENIEPLALRHVLVNKPEVKYVGNIHGNEVLGRELLLGLADYLCEQYSQNDPNIRSLIHKTRIHLLPSMNPDGWQLSTNFGGQDYLLGRGNNHSVDLNRNFPDLDAITFEFERLGINHNNHLLKDVTRLAAPVIGARNSRCNPLDNVNTVCAELLVANYPYDESRSGALASEYSASPDDDTFKEIAMAYANAHADMASVNRPGCHVNGPDQSEAYNFGKQGGVTNGADWYSLKGGMQDFNYLATNAFEITLELGCKKYPLENELENEWNRNREALLAYLWKAHIGIKGIVSDDTGFLENAIISVVNLTGHTPKPIRHDVTTGVYGDYYRLLTPGRYEVTASHPGHYPAQRIVTVPQRQSSARILNFKLEPIRYEDGALFFDPPFIRYQHVVGDQPRIYKRSLFEKVTNTLLQARDTPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1B1</accession>
    <name>A0A194R1B1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1B1"/>
    <dbReference type="InParanoid" id="A0A194R1B1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="10966" checksum="39876415C1F2B94F" modified="2016-10-05" version="1">MESYEEDRDYTGLIMHEGRKEDPFTWESSVRLTLLGREEELGMYLEEREGRKRKWHQGDADKTMRREDADEKEPRKVPPKKIMGTYTPQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1D7</accession>
    <name>A0A194R1D7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1D7"/>
    <dbReference type="InParanoid" id="A0A194R1D7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="14"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="566"/>
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    </feature>
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        <location>
            <begin position="595"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="947"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1086" mass="125347" checksum="EF59AF449625BDDF" modified="2016-10-05" version="1">MDANLSFFKFPFVDAETSDLEFNKIKPLDGYDDLQSTLPSHGSLLANDDVLAEFLTADGPLEEPDLNGPTTLHCEICSKKFDNAKKYYGHLRVHSKDNLWICDKCPDQKFSTKQQLMKHGLTHKPLGWVWKCPQCTMAFEALWRLQQHLFAKHLDYRPYKCDQCDKAFYKPSDLKKHVDVHKGVRNFPCTSCSMQFRDKSNLKRHMLTHTNEKPFCCSGCGNRFKQLASMTRHKRYCPMNRNQNEIVDKTVRKNHCRVCGMTFQYKSALLEHCVRQHTNQSKEPENEEKVIDTNADANRTVDNIVDDILSAEDDYMTIRQQSNLAFNSQYITDPATDDYLMQVEFLKEINELHSLDDELLYNDIDLETFQNNQVFNSNIDIDYNPSDRNGEILFDFTECGKSMDHDIISALCQVKNDLPDEFLNVPDINFDRPELKVPETVDECEKIFESDVDLEASTNLAANLKQLIGENSVQYISSEDHDTFIISLNSEIDAAQLTDLLNIDVEKTEDNKIEELPIVPVKVDNINNVENKMDAVLEKEIKQIEPIKLDDKVEDIKGKEKKKVIFVCKICKKNFNKKDNYKSHIGTHNPSLRRHKCSVCGERFSYRSTLNKHVSAAHEPRVLSAHSCPHCDNTYRAHWMKVIDTNSDANRTVDNIVDDILSAEDDYMTIPQQSNLAFNSQYITDPTTDDYLMQVEFLKEINQLHSLDDELLYNDIDLETFQNNQVFNSNIDIDYNPSDRNGEILFDFTECGKSMDHDIISALCQVKNDLPDEFLNVPDINFDRPELKVPETVDECEKIFESDVDLEASTNLAANLKQLIGENSVQYISSEDHDTFIISLNSEIDAAQLTDLLNIDVEKTEDNKIEELPIVPVKVDNVNNVENKTDAVLEKELKQIEPIKVDDKVEDIKGKEKKKVTFVCKICKKTFNKKDNYKSHIGTHNPSLRRHKCSVCGERFSYRSTLNKHVSAAHEPRVLSAHSCPHCDNTYRAHWMLKNHIERDHERLTPYVCDVTQCDRKFYKKTDLEVHKRHHSGERPYVCEMCSSAFQQISHLKRHARTVHGHKAYVALSVYTVYIHVVNSIIVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1G9</accession>
    <name>A0A194R1G9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flexible cuticle protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_15003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTICLE"/>
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        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="17231" checksum="0BC74D07F8BC7A6F" modified="2016-10-05" version="1">MLQPSLRRNTFIYKTEVRIHNHQTNCAFFEDNSRCKQTIEKMKVFVVLAFIAVAVAAPQNPQDVQILRYESNNAGLDAYNFAWELSDGSLHEEQGQLKNQGTENEGIAVQGRYAWVGPDGVNYIITYVADENGFQPTIQQGPGGAIPSAVVASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1H2</accession>
    <name>A0A194R1H2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1H2"/>
    <dbReference type="InParanoid" id="A0A194R1H2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9484" checksum="28B8B710834F60BF" modified="2016-10-05" version="1">MFDVVFIFFLFLIAVTCVMNYMPGRSKKQEVTEDEVEDDVIPPPPLFAGEVIERQASTSRDTYVVISPPIDNHKTKDGCPIHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1W1</accession>
    <name>A0A194R1W1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1W1"/>
    <dbReference type="FunCoup" id="A0A194R1W1">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1W1"/>
    <dbReference type="KEGG" id="pmac:106714372"/>
    <dbReference type="InParanoid" id="A0A194R1W1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000750">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="709" mass="79001" checksum="8F8436F6D6F08EE3" modified="2016-10-05" version="1">MDSKYAVLGKENNKKNSNGIKVKRIKLCVENPSKLNGNHVAIQQVADQRDIKETFVEDLRETRKSLPVYAVRNRLLEEIKKNNTMILIGETGSGKTTQVPQLIHEQRLEGSGSIAVTQPRRVAAITLAMRVAAEMNTEIGSIVGYCVRFEDVTSVRTKVKYLTDGMMLREAVADPLLKRYSFIILDEAHERTVNTDVLFGIVKLAQKERNEKKLLPLKVIIMSATMDVDSFKNYYDECPVIYLEGRAHPVTIYHTKMKHEDYQYAALCTIFQLHTTSPANHDFLVFLTGQEEIETLMSNIKQIAKESSGPLIRVCPLYAGLPAAKQLQVWKKTPPGMRKIVLATNIAEASVTIPQIKCVIDTGFVKERTWCTSTGAERLRVGPCSQAAAWQRAGRAGRTARGAAYRLYTETDFGARKPHNVPEIVRCPLASTILLLIASGFEPLTFPLIDPPPEESVKASLLLLKELGAIENEANPKLTVLGKKMTAFPIDPKYAKILLSAPEFDCLDEALSLVAVLSSENVFHMPIHKREEALKVKQKFVSTLGDHITLLNVFKAFCKAPLKKQWCKENYLNHKNLSYAFDVRQQLLAICQRLNMTVTSCGAALDQLLKCLLSGLFTNCAWLRSVVGGARYATGSGAAAGLHPAGVLHSLRPAPPALLYTELLHTRRPYLVTVSVIQPQWLHQVAPDYARRCRATRTCPESIFKPTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R208</accession>
    <name>A0A194R208_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 4C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_14924</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R208"/>
    <dbReference type="STRING" id="76193.A0A194R208"/>
    <dbReference type="InParanoid" id="A0A194R208"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="483" mass="55714" checksum="D82C00783E455211" modified="2016-10-05" version="1">MFLWLLCLVIVLAMTLFRLKRRRLYRLASKIPGPDDELPFIGVAHKFTGTTEDILNSLQKYSYEAIKKNGILRGWIGHILYFVVVDPIDLEVILKNCLEKDDLHRFLKNAIGNGGIYAPLPVWRRRRKIMVPAFSPKIVETFIEIFSEQSEKLVSMLDECAGKGDVTMGPFLCRYTLDSVCETTMGIKLNAQNNPDNRFLRALKNILNFFCKRIFHLWLQPEWLYKFFHQYTEEKNYLKEMHDFVDGVNLYKYKTRSFLDLLIEFSGGENGYNDLELREEIMTLTIAGTDTSAVSIGYTLKLLAMYPKVQDKLYQELVDVFGNSDRPIDKEDLSKLKYLERVVKESLRLFPPVPFIIRKILDDISLPSGRTLPAGSGVAVSIWGLHRDPNYWGPDAEVFDPDRFLPERFNVKHACSYMPFSSGPRNCLGYQYALMSMKTALSAIVRRYKIVGEEESGPVPQIKSKIDVMMKAVDDYKISLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2D8</accession>
    <name>A0A194R2D8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Very low-density lipoprotein receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_07990</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2D8"/>
    <dbReference type="FunCoup" id="A0A194R2D8">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2D8"/>
    <dbReference type="InParanoid" id="A0A194R2D8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000105">
        <property type="entry name" value="Lipophorin receptor 1, isoform K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000113">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="558"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="645"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113527" checksum="DCFB7A4DE7EB0D6E" modified="2016-10-05" version="1">MKKRHKHNVFVFVRTESRTCTSNEFRCKTGRCIPLSWRCDNEKDCSDGSDEEPGTCIFTSYQNEFRCKTGRCIPLSWRCDNEKDCSDGSDEEPGTCTAQSSNCPEHKFVCASGQCIPAAWHCDDAPDCPDGSDEHHCEVEACGPEEFTCRGKHGECVPLTWMCDDNPDCSDGSDEKACNETCRADEFTCGNGKCIQQRWVCDGDDDCSDGSDEAKCPAPTCQPHAHFSCADGHCISARWRCDRDIDCPDGSDEAGCPTSPKVISPCVSTEFQCHDRVTCVHKTWVCDGDRDCPDGGDEAPEICRGNVTCRIDQFQCKDHSCIPGALYCNGEKDCPDGSDELNCTRPKPICDSKTEFDCGGGMCIPLSKVCDKKPDCPNFEDEPRDRCGANECATNNGGCTQRCIDTPVGYYCDCDKGYKLVDNRTCEDIDECLDPGSCSQVCSNEKGTFKCECYSGYARDPRDRTRCKATEGHPSLLFARRFDIRKISLDHHEMVAIVNDTKSATALDYVFRTGMIFWSDVTDEKIYKAPIDEGSLRTVVIGDQLITSDGLAVDWIYNHLYWTDTGKNHIELSDLQGNMRKILIRDSLEEPRAIALNPLDGWMYWTDWGQNPKIERAGMDGSHRQTIVSYDVKWPNGLTLDLVRKRVYWVDAKMSTISSCNYDGTARRLILYSTDVLRHPFSITTFEDWVYWTDWDKTAVFRANKFNGKNVEAITSTHTLQNPMVIHVYHPYRQPDGVNHCAAVNGHCSHLCLPAPQLGPAAPRVACACPTGLRLLPDNQMCVEDNAIKPDVEVHKPRNVSNEPIVVHEKPVTSLLLKLGRAIGEVIDSTEEPDAEEPTPTTNANSEPMKAYWETDKKELKSKNQPLIDLYLKGVALERIPDATEEPIKEFHYNLERLRQYLPDVIVNNIKAVPETPKTNTGISSSGRDAGVVAGIVIAVITGVVVLAALIIVVMYRHYMHRNVTSMNFDNPVYRKTTENQFALEQNGYAPGSKLYPSTVGEEAQEPLNTPGTNEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2H5</accession>
    <name>A0A194R2H5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2H5"/>
    <dbReference type="InParanoid" id="A0A194R2H5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="178" mass="20279" checksum="35AF262033AA1156" modified="2016-10-05" version="1">MSSRIYPKVWTEFERQADDGRILNFSIEDVPEDMWKSAVEFMLGSYIKEDVWWKTAGTAEDPEAIQEYRVLLTSIIEQKMSLACFLTAPEGAGRTLVGVNMCMPQDKDRFVEHVPVRTKELGFKVTGGIFTSDSAQKSAEKADMECLFKISYKQFGEQCDIEFDSETEDLKIFGAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R313</accession>
    <name>A0A194R313_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R313"/>
    <dbReference type="KEGG" id="pmac:106714225"/>
    <dbReference type="InParanoid" id="A0A194R313"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="561" mass="62038" checksum="2D2465FA8AB1DAE3" modified="2016-10-05" version="1">MADGSHERWGSQLEYLLSCLGYAVGIGNIWRFPYLCYRNGGGAFLIPYFLTLVICGIPLVYLETTLGQFASAGCISIFNINPLFKGAGYAVILVNIIATTYFAAIMSFPLLYIYHSFTSPLPWQSCGNSWNTDRCSELTGNSTSVIGNTGAVTTPEDEFFHIRLLQMSPSIHEIGGIVWPLFCCNLICWVFVYLCICGGVKSVGKIVYFTVLFPYVVLFALFIRGVTLPGAGQGILYFILPDWSQLKNPKVWADAATQIFYSLGPGWGGLVSMASFNKFHYDNLRSSIIIPIVNSGTSIWAGFVVFSVLGFAAERAGVPVSQVATAGPGLAFITYPAAVTLMPAPNFWAITFFVMLFFLGIDTMFVTIEAVITGLLDEYPKLHRRRKLITLMTCLILFSISTICNTKAGLHIIGLLDSHVAIACVPIVCIMELVAAVYTYGQDKLRTDVLFMTGRPLKRFWLILWRYILPVILMVVAGYSLREASGIAGWCVALASVVCIPFFAAKTIYMSRGPLLQRIKENCRANALWGPAETEVRAQWNTFRKKKLHVSLDILNNHADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3G1</accession>
    <name>A0A194R3G1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A194R3G1"/>
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    <dbReference type="InParanoid" id="A0A194R3G1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264887" description="Histidine-rich glycoprotein-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="139"/>
            <end position="164"/>
        </location>
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            <end position="181"/>
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        <location>
            <begin position="190"/>
            <end position="199"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12059.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30447" checksum="A330AEC5E9C00609" modified="2016-10-05" version="1">MKLLLWTVLLACALASSHGRNFGLTDNESKANGPAAGAEENAGLVASNIDQITAGTEKKEAKSTNQESGGGHEHHAHHHKENEEKGDKGYKSHHHHDKGEHGHKEHHHHEGHHDEHGGHKKKHHDEHDHHGEHHEAAHGHKGGKFGHKKGHKKGSKTTGYHHKSHKDEYHKEHKFYDDFHKGGHHHKHGDFHGHHDKKDGHHKKGGHHEKGHHEKHHGKKGQHDKGHYDEDHKGHKGHHGHEEHHAHHHEHGKKGGHAGGKEHGYSHGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5R1</accession>
    <name>A0A194R5R1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5R1"/>
    <dbReference type="STRING" id="76193.A0A194R5R1"/>
    <dbReference type="KEGG" id="pmac:106713506"/>
    <dbReference type="InParanoid" id="A0A194R5R1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264944" evidence="2">
        <location>
            <begin position="24"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="46571" checksum="FF57467D7445CB3F" modified="2016-10-05" version="1">MFVRFQDYVCVFLCVVIISSGRASVLKEVLEDHLKDISHDEAVESVKHDKEKGDKKHQIESQINDSQISQYAKVADDSKYSKKEHDSKKSTDNDVYAGYNSKQDKAEDNETTGFKRGHKKGHHKQGFQNSYHKDESSNKSTYYDDFNDENDQSSYNTRLNTNDNEGRRSYKGGHNNGQEYSLDNYNSRGHNNYKNNGNKQIEHQDYAKNHYLDDYENYNKHRNNHGTHRRDNSRNRHEYHVPQNQNRGWDWQSWDDRNQWERPKWDRNQGRNADYRDPGYDDRGFGYDNGYGYGLKYGYGFDESQAQPVAHIPSDPPVLAQRKQTITIYEDPRYDGSSQGQLRREEGDYLHLDIQPSHRRYASYDSSYYDTPRRERAMETSRINRLVYNYRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7S0</accession>
    <name>A0A194R7S0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7S0"/>
    <dbReference type="FunCoup" id="A0A194R7S0">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7S0"/>
    <dbReference type="InParanoid" id="A0A194R7S0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33369" checksum="7771B08A317CCC20" modified="2016-10-05" version="1">MAPLPAPIPARRSRGTSRPVVSPVTSVLRMRGVGADDVLVRRNYMDSLCKDHFLQRQYRKLDGGVLWSRNERNLDCTVTFQTHSILQRFMLHFDMLQLDCNDHLYVYDGAHATAPPKADLSCRNTKQQVGALFTRSNFVTLKYVTDNWGTDANGFKLVITAVKDPKHGCKEFRCKQREFCVSADLACDGVDHCADGSDEDTAALCPENGGAGGGGLWLMGAAGGGVLALAAAALALCCYCRRRTPSRRTHLHLAQMASSNGAGSAGKPAGGESPPACPGDTRLPGNWALPAGPRGYNAARPGRLRASAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAG9</accession>
    <name>A0A194RAG9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAG9"/>
    <dbReference type="FunCoup" id="A0A194RAG9">
        <property type="interactions" value="2008"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAG9"/>
    <dbReference type="KEGG" id="pmac:106713235"/>
    <dbReference type="InParanoid" id="A0A194RAG9"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02667">
        <property type="entry name" value="Peptidase_C19K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF781">
        <property type="entry name" value="LD34905P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="197"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="940"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
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            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110702" checksum="B90EEBAAA658CF08" modified="2016-10-05" version="1">MVKKKRQSDPGENGDDSTESCDESVKSACPHVAKAVDLTRLKKSLKSGGFEKECSECKKSNKIEVPDPNFEEDVTLWMCLRCGSQLCGRTRNKHALNHFNTPHSDCHSLTANTTTWEIYCYSCNNEVTASSSKKLHECIEYVKKQASCNKLLPSFEPLFDSQPKNFDVPLPVESIIKNDQYSKGKEKAIALSLPRVRGLSNLGNTCFFNSVMQCLVQTPYLQDVLHEMATPGERFTLPGGKLKLKVDGDDGKEVELPPITGQLGEWGTLTRTLSETLAELQAGEGGVYTPRKLLSALVNKLPQFGGGDQHDAHELLRHLLEAVRSEDLRRYQSVILSSLGMSSKVDPAKVDGEVKQKVKFYGQQASDTMLRPEQVFRGFLVSTLECQECFHQSDRAEYFLDLSLPVAATRPQPPALVRRKTPNEENMYNVQEENKTSKHQLKKERMAARKAARKSKGNSNKEKTPGEANGGKEEGKSSSEQSDADVEDNLEELPRRADTHCASVGSQAIAHTAANFAAYHMESGYNSEKVVSSDSIRASPAPHDKEKTDGTPEAPDKDREYVNCSTSTTAIPLEYKSLASLDNLSNPDSGVASPEATKHNSTETVDNVDSPINGKELGSHSSLSSEINLDLSSPQHSKLSPVKTEYERPVSRIAFAPEYTNEVVTRGISVKGSRNLLEHSGESSYESLPESKPPEPAPYNVSNHQDVTNILDKLKLDMDDPQASKPAIPLPAPAPAPAPAESPVYPPPTVPRPKINIEPEKNQRDFLSLNRQSPMSSRYVCDEDECSIQSCLSQFTALELLTGNNKVGCETCTERINGKDGKTVYTNATKRFLVSSPPAILILHLKRFQIGPRCMFRKMTKHVDFPTILDLAPFCAMDKLKKLPNVTRGQSELLYSLYGVVEHSGGMHGGHYVAYVKVRQPVKPGDPRWWFLPKSANIPASSGGDGDADSESDLSGYESGEGPAPMPDPPAGKWYYVSDSMVSEVTEDKVLRAQAYLLFYERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBM1</accession>
    <name>A0A194RBM1_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Fungal protease inhibitor-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KPJ15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7278554at2759"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11138" checksum="289DCB5C47E35ACF" modified="2016-10-05" version="1">MKATLVLALLTCVLALVYGDLVCGTNYCKQHPCTTRVAPTSCRSPSLYRPNHAGKCACCPACVTLLGEGAACKTYSKELGETPSAVCREPLKCLTGVCTKVTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBN3</accession>
    <name>A0A194RBN3_PAPMA</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmac:106712821"/>
    <dbReference type="InParanoid" id="A0A194RBN3"/>
    <dbReference type="OrthoDB" id="7425674at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265058" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="14179" checksum="58BA74F60006D03C" modified="2016-10-05" version="1">MKAPLAALATLVLLATSAGALNVFQYNTEVVKGASCSTENKPLGPFFIPDNQCSGVLYNLTQHCERLELVKVSVTDYAHVKVTIDDSLSSVSIERSPNLVSTCPGRAAVRAVLGCGLHSSDEAPLAGHDSVLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCT8</accession>
    <name>A0A194RCT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Smoothelin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCT8"/>
    <dbReference type="InParanoid" id="A0A194RCT8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21200">
        <property type="entry name" value="CH_SMTN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="28045" checksum="C3B561B89D858AB3" modified="2016-10-05" version="1">MTPPPPQPRPCSHFNRPPLHSMYINMSAKPPIIECNRHGSWAFGDAEEEEVTTVTSSVRRNSTEKTVSTSTTIKNSKVIESMTRAAPKPVSPFAKFRQLEKQNTINSPNAPASPQSPGSPSQPYFKFTDPALQASAVTIKERLLHWCRDKTRDYENVKLENFSTSWADGLAFCALVHRFVPDAFDYRALSPDKRRHNFTLAFKIAEEKAGIYPLLDVDDMVAMRKPDWKCVFTYVQSIYRRFKDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD65</accession>
    <name>A0A194RD65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD65"/>
    <dbReference type="InParanoid" id="A0A194RD65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13826" checksum="170C64C6B191A896" modified="2016-10-05" version="1">MFESLVSRLTSPTVSRRRHTVHAAREVCSEPEEEAAPVQRRTRTAKQLLDKRRKARLSCADLTTAGNAEPEKSSRIEALKAFLPLRQSKSLGRLDGLKEPTPRPSNCETSNGSPYYGITSTCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDA8</accession>
    <name>A0A194RDA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucuronosyltransferase 2B15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDA8"/>
    <dbReference type="InParanoid" id="A0A194RDA8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="579" mass="65836" checksum="A54DEA70582F3AD4" modified="2016-10-05" version="1">MNCCSSLSKGRFREGEVLDEEGFREKHPFVIQSHSSGNADCLNDRRPSRDNGSMLINRKTFFISLLVLIANSEGLRVLVFFPMMSKSHSILGQGVVSRLLEAGHEVVHITSYPRSKPEPRLKELNVSTIGERLRDEMKNSDNPFALRNLVGKGNVGDSVLFLYFTYDLHRRVLEDKLVVDLLSDTNEHFDAVVIEWFFNDVVAGIAPLFKCPLIWFGSTEAHWQVLQIMDEIPNPSYNVDIFSKSRSPLTFWERIMELWMIFKKSMMMNLVVVPFERSLYNRVFPSIASKRGVTVPSYDEAIYNGSFLFLNSHPSIGTPFKLPQNAKYIAGYHISKEMNPLPKDLQILMDSAKHGVIYFSMGSNLQSSDMSETMKDSLLKVFGQLKQTVIWKFEQDLPNVPSNVHLVKWAPQASILSHPNLKVFITHGGQLSTTEAIHFAVPVVGIPVMADQHVNMRSVELKGSGLVVTLAEDMAPKVKIAVEEILQNPYHKKKAKEGSEIFHDRILPPGEELVHWVEYVVRTRGASHLRSPALGVPLYQKLYLDFIIVLITIVYLMVKFINVLRRKCSDYKSKKLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDC2</accession>
    <name>A0A194RDC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lachesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDC2"/>
    <dbReference type="FunCoup" id="A0A194RDC2">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDC2"/>
    <dbReference type="InParanoid" id="A0A194RDC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF271">
        <property type="entry name" value="DPR-INTERACTING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265119" evidence="9">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="240"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="381" mass="42775" checksum="3A8EFB648E012A58" modified="2016-10-05" version="1">MRTGKSCFWTMLQALAFLPSMALKDSQTTTKRVIEEPEFARPIGNHTFFLGREAVIGCAVSNLGKHKVGWLRAEDQTVLTMHDRAVLGARYSVNMDAPHTWQLRIRPLRAEDRGCYMCQINTQPTMIWQIGCIDVFVPPDIISDDTSSDVSVQELENATLTCKATGHPPPKITWRREDHEPILLKKPQTREFEKVESYVGSSLPLLRVDRRQMGTFLCIASNDVPPAVSKRITLLVNFAPTVKVPNQLLGAPLGTDVKLKCYVEAYPNTINYWIKNRGEMLLDGPKYTIREEKTSYKVSMWLTIKQFSKSDIGTYNCISTNSLGKSEGTLRLYEIKLNSPSEDFNNQISVAGGPMVFVIISTLYVSTEELGPSPKLGVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REB3</accession>
    <name>A0A194REB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REB3"/>
    <dbReference type="STRING" id="76193.A0A194REB3"/>
    <dbReference type="InParanoid" id="A0A194REB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="209" mass="23087" checksum="FFA8A5CE621BEBE9" modified="2016-10-05" version="1">MSASAPHAHGRTPVRRRGHQHHPRLRGDRVPAPGASTNTTPSKQVTLDTQIDDVVPCVNSVSESQELTRTNSDDALSNRNTIEDSNIDDEIEFDVRIIGAESNGSSDDEFSFKEERSAGDGAEMTVIASDISDDDPETAELAKLRCTSECTEVLAARENRRRRRCADYPGLAFGSSIFSSDTMMKFSIIKNELQNIKNTALKRVMYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF45</accession>
    <name>A0A194RF45_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF45"/>
    <dbReference type="FunCoup" id="A0A194RF45">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF45"/>
    <dbReference type="KEGG" id="pmac:106711429"/>
    <dbReference type="InParanoid" id="A0A194RF45"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="30418" checksum="A9F0B41B903F3F02" modified="2016-10-05" version="1">MVQKKPKKKVGKKVAAAPLVVKKVEPKKIVNPLFEKRTKNFAIGQDIQPTRDLSRFVRWPKYIRIQRQKAVLQRRLKVPPPINQFTQTLDKTTAKGLFKLLEKYRPETEAVRKERLRKAAEAKIAKKDEPPAKRPNTVRAGTNTVTKLVEKKKAQLVVIAHDVDPIELVLFLPALCRKMGVPYCIVKGKSRLGALVHRKTCTSLALTHVESGDRASFSKLVEAIKTNFNERYEELRRHWGGGVLGNKSNARIAKLEKARAREIAQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHM2</accession>
    <name>A0A194RHM2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">28S ribosomal protein S6, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHM2"/>
    <dbReference type="FunCoup" id="A0A194RHM2">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHM2"/>
    <dbReference type="KEGG" id="pmac:106708790"/>
    <dbReference type="InParanoid" id="A0A194RHM2"/>
    <dbReference type="OMA" id="ATHFTIT"/>
    <dbReference type="OrthoDB" id="268530at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000014">
        <property type="entry name" value="28S ribosomal protein S6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17578" checksum="4947722032862CE9" modified="2016-10-05" version="1">MPTYELALILRAMPKQDLKTTLTRVSHAIFSRGGIIRNIENLGFRALPYKTSAHGLVHREANFFVFKIDTATKAVADLKEEYSRDVDIVRQRMFKTQTDCEHSCTLEEEMLPPAYREEVQKMIEIGKTQVDRFKYKFKYNSGLDYYPFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHX6</accession>
    <name>A0A194RHX6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Muscle LIM protein Mlp84B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHX6"/>
    <dbReference type="FunCoup" id="A0A194RHX6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHX6"/>
    <dbReference type="InParanoid" id="A0A194RHX6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="17229" checksum="A3084819B9684163" modified="2016-10-05" version="1">MPFKPVDNPKCPKCGKSVYAAEERVAGGLKWHKMCFKCGLCQKLLDSTNCSEHEGELFCKVCHARKFGPKGYGFGGGAGCLSMDTGDHLKGENACMMSRSARGPARSGSAADRTASVRKRSSSDCSPLPIWATMCSEATVRKPLCKRLHGFATLQTHPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI43</accession>
    <name>A0A194RI43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI43"/>
    <dbReference type="STRING" id="76193.A0A194RI43"/>
    <dbReference type="InParanoid" id="A0A194RI43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000052">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="348" mass="39483" checksum="627F6B1BF8EA034F" modified="2016-10-05" version="1">MRRRDENFPDNGFEDGGGYMQVKIAKLEAQFSSCVGREVTRLSNIFNGVSIYVNGFTKPSADELKELMAQHGGVYHTYQRSNDYIIASNLPDTKVKNMSLSKVVKPEWITESIAANSLLDYRKYLLYKNSRTQPQLNFNKLIATKIKTDESHLKDERENIEENLTYDSDKGLNEMGKSSNVSTTDTKPVLNKVNRNDCLAKTAVDPNFISEFYNNSRLHHISQLGAFFKQHVNDLRDSSDFSFPARAALKSNILSSSRTSLHADTSFDNGKVIMHIDMDCFFVSVGLRKRPELRGKPVAVTHSKGSKPQTKREGVDRNIEFNLYKQKQAGTLKWSGSQPQIFMTKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ59</accession>
    <name>A0A194RJ59_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acyl-CoA reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ59"/>
    <dbReference type="InParanoid" id="A0A194RJ59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9411" checksum="6B23A0AA5B7F4E30" modified="2016-10-05" version="1">MVARPPSPVGALIPRFFAGRHVLITGATGFMGKVFDVIRQTNPAQLDKLRVIPGDVSEPGLGLPQSALQILKEVIGVLCRTHFAFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJH1</accession>
    <name>A0A194RJH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJH1"/>
    <dbReference type="STRING" id="76193.A0A194RJH1"/>
    <dbReference type="InParanoid" id="A0A194RJH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02848">
        <property type="entry name" value="E_set_Chitinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013540">
        <property type="entry name" value="ChitinaseA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08329">
        <property type="entry name" value="ChitinaseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="191"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="594" mass="65655" checksum="35F72510762420E5" modified="2016-10-05" version="1">MLALGTDSPEVFLDDAIVFIALALGGSAQPHVRFESDMRHHILKLLSGVSLLAFAKCGPPGKPSLGWGERTFAIVEVNQAATAYNQLVTRKDSADVTVTWNVWSGDPADTARVLLDGDEYWSGASGAATTATFKVTKGGRYQMQVELCNSDGCSSSEPTEIVVADTDGSHLPPLMYTLGEKNKPFKQSSGKVVGAYFVEWGVYPRKFPVDRVPIPNLTHLLYGFIPICGGDGINDSLKEIEGSFQALQRSCSGREDFKVSIHDPWAALQKPQKGLSSWNEPYKGNFGQLMSLKQARPELKILPSIGGWTLADPFFFFTDKEKRGRFVDSVKDFLLTWKFFDGVDIDWEFPGGKGANPDLGSPKDGDVYVELMKELREMLNDLSEETGKKYELTSAISAGWDKIQVVDYSEAQKYMDHIFLMSYDFKGAWSNDTLGHQTPLYAPAWNPKETYTTDFGVKYLLAQGVNPKKIVVGVAMYGRGWTGVHNYENNNPFTGNATGPVKGTWQDGVVDYREIANEIAMGKWEFHYDNVAEAPYVFRPSTGDLITYDNPRSTIAKGKYVRNNKLGGLFAWEIDADNGELLNAMNMGLGNSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMH1</accession>
    <name>A0A194RMH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TGF-beta-activated kinase 1 and MAP3K7-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMH1"/>
    <dbReference type="STRING" id="76193.A0A194RMH1"/>
    <dbReference type="InParanoid" id="A0A194RMH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="406"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="583" mass="65450" checksum="4B40F32C9AE82153" modified="2016-10-05" version="1">MQLFHELKQKFPGVPDHVVSSTIELYCHDKQACETHLHREVKASLTHAYHASSSAAARQLNELKVNVPVKCRNQPIVKHEIVRTSAVKSVTCQGPQKAVISCNSIGEENEKKINTDANQNVVEASIDNEISKCPSPVTIINIDNCFAKYSAESPSDPELTNDNKKEVNENHGKEELSIQKTGSDATQSESTNYKILKSNKIKCNLNERLEKGKEKKTIKKEPQTVKPVEEKPKRPNTLDFIKPNPDIAFKETLKQDNPEPCRSVSPAVSTQKDNQSKEKPNTYRRECGYPLNLSVNVNCHMDLSRSYVDPWMEDYESPRAITSVNLTVCTPTSNMASPVRETRDDEGGFEGHVTVTVSPSTTRPPRRRAPPPPPPAQPPPTRLESPRPSRTAPEPPAGSNHGTIDRSLIERQKERLSRLAAALAQEKSRVAQLSRETQILAAPPPSPTATQRLKNYVERLRDECNTLSKRLEMANNEPDDSDSFYRNIYTGQRPSAMWQCHMCTFRNHELLTKCEECEMPRILVGTSPSRNHDSGFGSFRDRNRRGIPHDTSHHEVNEVPHVIESTFPNVNQALRSQSLSHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMI0</accession>
    <name>A0A194RMI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMI0"/>
    <dbReference type="InParanoid" id="A0A194RMI0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF118">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="94"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="56937" checksum="CC7C14F7FC8742F3" modified="2016-10-05" version="1">MILVSFELYNTIKRRHKTPWYKRLHYDQNSYVDKSGMRVIVGHYVGGNSGGNLSQETVNANNYAPVQGAGEGGRPVQLSPREIITARELYTLHSYNILIILVDDASDRKYLGKELEDAVAKLENVQILRSTQRKGLVGARLMGARSAVGDVLVFLDAHCEVTPGWLEPLLERAGSDDVFICPHIDLLSEDTFAYTKSIDAHWGAFSWRLHFRWLMPSTEVMKQKAEHPSKPYPSPAMAGGLFAVTKSLFWRLGGYDEGMMIWGAENLELSWRAWQCGARVEITPCSRVGHIFRRHSPYKYPGGVSKVLNSNLARAATVWMDEWADFFFKFNPAVAVIRDEQNVGDRVQLREDLKCKSFEWYLMNVWPQHFFPTKDRWFGRIRNDKGGCIGVISSTPGLGGPASKVHCGSDLDLDSLVVYTPEGRIMADEGLCLEQGNGRAVWKGCSDSKKQIWKQKGPRLKTMDGLCLTSLINSSSNVTDNPLTSKKCVKSDEQIWHFERVPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN96</accession>
    <name>A0A194RN96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-27A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN96"/>
    <dbReference type="FunCoup" id="A0A194RN96">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RN96"/>
    <dbReference type="InParanoid" id="A0A194RN96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001149">
        <property type="entry name" value="Rab40, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="209" mass="24458" checksum="FB10BDAECF9B5909" modified="2016-10-05" version="1">MDYDYLIKLLCVGDSGVGKTSFLYKYTDGVFHTQFISTVGIDFREKTVIYQQNGRQHRIHLQLWDTAGQERFRSLTTAFYRDAMGFLLLFDLTNEASFLEVRNWIEQLKTHSLSDDPDIVLCGHKCDLQEKRLVNQNRAREFAKNYNLPYLETSAKTGQNIDRAIEILLDKVMYRMEHSVEYAMLCASGRRRQSLQKLQAKQDRKFCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNN8</accession>
    <name>A0A194RNN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNN8"/>
    <dbReference type="InParanoid" id="A0A194RNN8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="239" mass="27115" checksum="27102625945559F6" modified="2016-10-05" version="1">MDIIKTAETSWMHLAKNRERLKVVQTSIIYQYGRLHAIAFVIPSNGSQQAFDDIGFIIVVKDNSMKWRTIGLFDTVNRTDDDFEWFAQIFNKDEIEHKVVGYTVPKIIHHLVIPDKQFYLTELPVVVNINLCPSILTFNNLISGFYSPCYHSCSVSDYEIGAKSCASYHGVEGAAVFNVASNKLLGVATWGPTNMKPLPVGFAVPNSKNFFEDYNCAKRIRDDENYHDSGYQELCDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPA3</accession>
    <name>A0A194RPA3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPA3"/>
    <dbReference type="STRING" id="76193.A0A194RPA3"/>
    <dbReference type="InParanoid" id="A0A194RPA3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="437"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="664"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="919"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129495" checksum="BF7792CB96F2D466" modified="2016-10-05" version="1">MLCEDIKVCNAALEVYVRRAYTSYEITCLQHLALSGELGVVHFQFVLPTGHPNRIPISQSEIELSAAQDAEGVPAELSTAAMRKCHHRTGALAAFLSFEQFAQYADELLDLVHDFASSATVRKEDLQALQEGSESRESTSINVGMDYKQIVDATDVPLEPIHILMIGVRDNGEIDDVAASRRFGSFCRAHRHDLHAKRIRRITFMLLIKRQFPKFFTYRARNDFTEDTIYRHLEPASAFQLELYRMRSYDLEALPTSNQKMHLYLGKAKVKKGQEVTDYRFFIRSIIRHQDLITKEASFEYLQNEGERVLLEAMDELEVAYSHHLAKRTDCNHIFLNFGPTVIMDPAKIEESVLGMVMRYGPRLWKLRVLQAEIRFTLRMGPGVPTKNVRLCLSNGSGYSLDIYTYEEVSDPRTGVIMFQSYGPRQGPMHGLPISTPYVTKDYLQQKRFLATSQGTTYVYDIPDMFRQTIEKRWRECIEEGSVDGPVPDNVMTSVELVVEPDGERHVVEVTRLPGQNTVGMVAWRLTLFTPECPRGREVVLIANDLTHYMGSFGPHEDWLFYRASHYARQRNIPRIYVSVNSGARIGVAEEVKSEFNVAWLDAERPERGFNGRRQQQHQLHELFSLSEIPRPHRRQASSGINSKYSLISVDKLSMVPIMRCADPIDRPVEWVPPRSAHDPRLMLTGDAHRPGFFDAGSFDEIMRPWAQTVIAGRARLGGIPVGVIAVETRTVEFTLPADPANLDSEAKTKARLGGIPVGVIAVETRTVEFTLPADPANLDSEAKTMQQAGQVWFPDSAYKTAQAINDFSRENLPIIIFANWRGFSGGQKDMYEQILKFGAEIVRALRGATAPVLVYIPPGAEVRGGAWAVIDPSVNSQRMEMYADPEARGGVLEAEGIVEVKFKQRDILKTMHRLDPELLRLGARISEMKEQMKEISKNLDRRGSIDDVLVRTDAGKQAECKVRELEADLLAAEKTVKAREKELSPIYHEIAIQFAELHDTAERMLEKGCIFDIIPWRWSRRLLYWRLARLLRQNAQERRVQEAVQPATHMDQGAAAATLRRWFTEDQGETQSHQWEHDNEAVCKWLEAQAGAEDSLLERNLRAIKQDAVLQACNALVMELTPSQRAEFVRKLTALEMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPK9</accession>
    <name>A0A194RPK9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPK9"/>
    <dbReference type="FunCoup" id="A0A194RPK9">
        <property type="interactions" value="1315"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPK9"/>
    <dbReference type="KEGG" id="pmac:106713841"/>
    <dbReference type="InParanoid" id="A0A194RPK9"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.20:FF:000002">
        <property type="entry name" value="ATP synthase subunit O, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="209" mass="22577" checksum="FD1CCFBBC7DAC5E5" modified="2016-10-05" version="1">MSLMKTNMLVRSLSTSSAASQLIKPTVQVFGLEGRYATALYSAASKSKSLDVVEKELRQFQQSIKADAKLKEFIINPTLKRSLKVDALKHVSSKVNLSATTSNLLGLMAENGRLGKLDAVINAFKIMMAGHRGEVTCEVITAKPLDQAQRQSLEAALKKFLKGNESIQLTAKVDPSLIGGMIVSIGDKYVDMSVASKVKKYTEIISAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ83</accession>
    <name>A0A194RQ83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ83"/>
    <dbReference type="InParanoid" id="A0A194RQ83"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8451" checksum="AA21069BABA2B7CD" modified="2016-10-05" version="1">MNKFCKSSLCVEKKVRERYVLNGRRVVAVPGGVDAIRLPQDFSDSTTLTCHRPVCGLELSVRTEEDSPPALRVDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQY4</accession>
    <name>A0A194RQY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pupal cuticle protein C1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQY4"/>
    <dbReference type="STRING" id="76193.A0A194RQY4"/>
    <dbReference type="InParanoid" id="A0A194RQY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF5">
        <property type="entry name" value="PUPAL CUTICLE PROTEIN C1B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="182" mass="18619" checksum="2ECFD59EC0CE9D1E" modified="2016-10-05" version="1">MSMPNAILPIKALPFLIGDISLTGFQAQLNMMLKLLIVVCAVAATNAGGLLSPVGVYGGHYGTIGAWNPYGSYPAQPAIASQQSNIYRSPLNLGQVSTFSKAVDTPFSSVRKSDVRISNPGVALAPAYQGIAAPLVTHYGVGAPLAAPVAKVAGGLLGVAYSAAPAVSHMSYTNGLGLAYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRF3</accession>
    <name>A0A194RRF3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vam6/Vps39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRF3"/>
    <dbReference type="FunCoup" id="A0A194RRF3">
        <property type="interactions" value="2065"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRF3"/>
    <dbReference type="InParanoid" id="A0A194RRF3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="14"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="532"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="853" mass="96299" checksum="F9F524271C230368" modified="2016-10-05" version="1">MHEAYEASHLLNATVQIEAIAAYDDNLLLGTRQGHLLMYSLSATNGNQKYELQLLRYCKNFSKKPIQQIEVIPEDNLLLCLTDNLLSTYDINGVNFPFIKSIPQTKGASLFALDKKTGESNSVVHLCVAVRRKLQVYYGKNGEFKQHQFEFTVPDVPKVMAWGQEYLCVGFKAEYTLFDLSSGKPKELFPTSSSRSLEPTIAKYSDNSYLLGRDSTSVLVEEAKDIEIKKTIKWAEPPLAVVWETPYILGLLTDRVIVQTVEPSMFIQTLPDLNKARLMYRCFGVALVNGHGGCFNCSPEEKKQTIHSIQMLSALELFDEKNYAQSMKVFIQLNTDPADVIKLFPELDNKPGAEDDGKLKGKDLQNALTALINYLVQVRLKFAEAVEKGNIDNADKMTPGASSDITSHRNVTQQLELIDTTLLKCYLQTNDAYVASLLRLNNCRLEEAEKTLLQHGKHSELIILYRTKGQHTKALQLLREQAKQADSSLKGYHPTKSYLQSLGSEHINLIFKFSDWILQEHPEEGLKIFTEDIAEVENLSRPKVLDFLLREHKSLVIPYLEHVIHTWNETNSLFHDALISMYREKILEHKNKSGGTTDEEVKHTKAKLLAFLEKSTHYTPERVILPFPNDCLFEERAVILGKLGRHEQALAIYVQILGEVERAIRYCEQVKENSTSKGPDVYVILMRILMNPEQGGALAGPLANVPRHPNSTVPDLETALAILEKHADHISPVKALSVLPNSVPLVRLKHFLESALERHLTEKRKMQVLKGLLYAEHLQVKEVKHYHESKSIVIHDYNVCPVCKKRFGNQSALHVRKVGSVMTRGDATAPQRMPTAATLCRRLCGPMDKASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRN0</accession>
    <name>A0A194RRN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Nkx-2.2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRN0"/>
    <dbReference type="STRING" id="76193.A0A194RRN0"/>
    <dbReference type="InParanoid" id="A0A194RRN0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="35198" checksum="2196CF15F797BD6A" modified="2016-10-05" version="1">MRSAEGDGESRAPPLLAPAGLLWSPLLLPPWGPAFLPALYPAAFRSAFPGLLDSMKMPGQRPGFQISDILGLNEAKGLETAPAPTGLGCGLELPPYAPPQHHYSHDLLRHHQPWLSLDQHEPTGGIGQQASPDSTSRASELSYVGASASSPTITDPRHDQDQDQDHDDIDHEDEDHDQPTNTSDPSLAHKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAVQEKGAHDLNVGSLNSPRRVAVPVLVKDGRPCIGKPDGLPPLGMSLPPYQPMHHQPPVGHGSQPSGCWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAN7</accession>
    <name>A0A0N0PAN7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_02876</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461184">
        <property type="protein sequence ID" value="KPJ07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAN7"/>
    <dbReference type="FunCoup" id="A0A0N0PAN7">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAN7"/>
    <dbReference type="KEGG" id="pmac:106718886"/>
    <dbReference type="InParanoid" id="A0A0N0PAN7"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="64"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="32656" checksum="C86B4152EE26242E" modified="2015-12-09" version="1">MGYDIGWIIPRLRNPGRLWTCASSITVAVVGLFSKIIIEFLNKTTVHNREALARAVRRPPGVPLLTVSNHHSCFDDPGLWGVLEARTLLSRARMRWALAAHDICFTNALHACFFALGKCVPVVRGAGVHQPAMDFCVERLAQGEWVHIFPEGRVNVDKENIRFKWGVGRLVAESWARGRTPLVLPVWHEGLDRVLPNVEPYRLRLRKRLQLCVGEPIALAPLLHSLQTANASEEETRRVVTERIQLELHRLRDAARALLPAAPTAPTAPTPPTPHAAPTVRMRNGIERDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAQ2</accession>
    <name>A0A0N0PAQ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAQ2"/>
    <dbReference type="STRING" id="76193.A0A0N0PAQ2"/>
    <dbReference type="InParanoid" id="A0A0N0PAQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="571" mass="64545" checksum="66AA2BA22CB04A88" modified="2015-12-09" version="1">MEKTYYSGRVRAGYDAGEPLLLTPYIEEKKLEEARKAAFVDPGYTLPDMESYSGYLTVNKEYNSNLWFWYFPVADKPIEETPLILWLQGGPGASSLYGLFTEIGPFRVTENSNLEEMKYSWGKNHSLLFIDNPVGTGFSFTDDDRGYSTNQTTIGENLYAALQQFLTLFPELRKAPLTLAGESYAGKHIPSLAVQILWHREEHEPVNLQGLAIGNGFIDPLTLQRYSHFVREVGLLDDKAADAMNHLETAVIQFINNGEMLKAYAIGENLYAALQQFLTLFPELRKAPLTLAGESYAGKHIPSLAVQILWHREEHEPVNLQGLAIGNGFIDPLTLQRYSHFVREVGLLDDKAADAMNHLETAVIQFINNGEMLKAYAYYNYLLQLFISESRLSNLYNYLQDDISLQGSYVDFIQRDEVRRALHVGNTNFTSIGVVYKKLVPDFMGSAKHWLEELLENYRVMIYNGHLDIIVAYHPSVNTYNALSFSGTADFKSAKRMPWYHDGRVAGYYKRAGNLTEVMVRGAGHMVPTDQPPAALGLISAFVRGVELDKDTAALVDEKKDTQRRRQLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBM1</accession>
    <name>A0A0N0PBM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homer protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Homer family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460955">
        <property type="protein sequence ID" value="KPJ10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBM1"/>
    <dbReference type="STRING" id="76193.A0A0N0PBM1"/>
    <dbReference type="InParanoid" id="A0A0N0PBM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035256">
        <property type="term" value="F:G protein-coupled glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007216">
        <property type="term" value="P:G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01206">
        <property type="entry name" value="EVH1_Homer_Vesl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000014">
        <property type="entry name" value="Homer homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045027">
        <property type="entry name" value="Homer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044100">
        <property type="entry name" value="Homer_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10918">
        <property type="entry name" value="HOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WH1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="18591" checksum="25A059DF820DA593" modified="2015-12-09" version="1">MTAGKETMGEQPIFTCKAHVFHIDPKTKRSWMSASSAAVSVSFFYDSSRNLYRIISVEGTKAVINSTITANMTFTKTSQKFGQWSDVRANTVYGLGFASEAELGKFIEKFQEVKEAIQAQQCGGKAAPNGSSGAATPVASATASPLLAGRAPPDEPPALSPAQVFQLLTNCIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC63</accession>
    <name>A0A0N0PC63_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC63"/>
    <dbReference type="FunCoup" id="A0A0N0PC63">
        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC63"/>
    <dbReference type="KEGG" id="pmac:106712986"/>
    <dbReference type="InParanoid" id="A0A0N0PC63"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="38879" checksum="7A2BE2E34954CAA9" modified="2015-12-09" version="1">MEANNSGNQVAGALTYPDRNDDNVESVPVQPRQPSNLQGLLRFAMEATKSEDAPGTSEFSPMDDERRTFLEEALKSLTVDVPKVLMDAVKVLSDAEKMNSIQLGQELPDDVAAAFFNIQEFICDIDVANDFHKIGGFSIFPICLSSENATVRMEALTILAEMCQNNPYGQARALDAGLMYMLVQLANTEEGNFLVTCLYAISCMCRGYGPACDELFANGGGALLSDLVRNPNIRVRTKAAFLVSFLAINHPSAKEIFLENNVIGNIATSLDRGLDGSTSCTLHALHALLQGQELPPQVNDPKIKLKKVLEKLENTKEIKYAEYTDERKVLKNIMKILKNVPEVEDVNDEEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCD1</accession>
    <name>A0A0N0PCD1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RNA-binding motif protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM RBM42 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCD1"/>
    <dbReference type="STRING" id="76193.A0A0N0PCD1"/>
    <dbReference type="KEGG" id="pmac:106712656"/>
    <dbReference type="InParanoid" id="A0A0N0PCD1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="37066" checksum="F6477AE8036CC0BD" modified="2015-12-09" version="1">MDDSNKFQQMQDEMSRFEAEISGSEIAAGPRAVISSSTFGAAQQRLERVPPPPPPPALLPPPFEPGVMDPGMMGTGLMYPGVSQPPPSSLMVPASVQRLRPSGPSEPYPGPMPFLRPGLPGPQLIPPPPPKPQPVVLSAAPKLYKQAKDDDDKKEKEGKKRKREPSPVAEVVVQREPTPPPAPAPPPQQDVAPKLKKEKKHRKVIRTAGGQVWEDVTLLDWPDDDFRMFCGDLGNDVTDELLIRTFSKYTSFQRAKVIRDKRTNKSKGFGFVSFKDPGDFIKAMKEMDGRYVGSRPIKLRKSTWRSRALDVVRRKEKEKAALLSLLMAGNKAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCK0</accession>
    <name>A0A0N0PCK0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 197</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460555">
        <property type="protein sequence ID" value="KPJ14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCK0"/>
    <dbReference type="FunCoup" id="A0A0N0PCK0">
        <property type="interactions" value="1746"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PCK0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="69573" checksum="357C559C96014CB2" modified="2015-12-09" version="1">MHDSIILHHIKEEDSINIDIVKQEDVTNKDDQNLDLQLKGIESPKAEDITDSYFDNFLEDSHPQSSDDDIQLSKLKTKKKKRKNKGDKSKKRVKDDELPVTFVSEIDNKLDETVKRSRKLKNLPEDFVELHTMSEEEMWQVRAKDVTREEFVTLKYKCDDCLTSFNTEKLMNFHLNGKHVLKSEADVQCDVCKAYFITRDNMSCHRALHLTAYKCRVCGDVTTRKRCILKHVRTEHGAPGTACVTCGKTFSSESKLSYHRGVCHKESPQCDCCGKVFASKLTLKYHLKILTPKQPEEKVHLPCKGCDKVFYSKKSYRAHVVIHNGETYPCPICGKQFQWKRNLARHTRNHRERDAGATHECRECGKTFSSRDCYNNHMRLSKRHVPEDAYIHSCNYCGKKFASKWCMVDHIDWDHLKVIKYQCSVCLKAFKTAKIMVAHMNNIHEGKKNKEPESEHLCEICGKSYKSVKRLKGHVWAMHTNRSSTKTFKCKLCPATFTWQTSIYKHMKMMHDSSKRNKQTRITTVKKQDLYPEIELTNRMEYFQQNLANNIQNMRSFMFTLVLYLLPLKTLGPLRSPPEITSNIKGLLGLFVELGWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDJ8</accession>
    <name>A0A0N0PDJ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460141">
        <property type="protein sequence ID" value="KPJ17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDJ8"/>
    <dbReference type="FunCoup" id="A0A0N0PDJ8">
        <property type="interactions" value="1431"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDJ8"/>
    <dbReference type="KEGG" id="pmac:106708198"/>
    <dbReference type="InParanoid" id="A0A0N0PDJ8"/>
    <dbReference type="OMA" id="YPMETMA"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000016">
        <property type="entry name" value="cyclin-L1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000031">
        <property type="entry name" value="cyclin-L1-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="48722" checksum="59E47D50CBD139CB" modified="2015-12-09" version="1">MSTTTVQNQTKNNNGTATKPQKTYGKIVLTLHNCLLPESIFKQTPSQVDGLDIETETDLRILGCEMIQTAGILLKLPQVAMATGQMYLQRFYYSKSFVRYPMETTAMGSIYLASKVEEKPCRIRDVINVFHHIKQVRAQKTISPLIVDQNYIELKNQVIKAERRILKELGFCVHVKHPHKLIVVYLQLLQYEKNRQLMQLAWNYMNDALRTDVFMRFPPETIACACIYLTARKIGLPLPNNPHWFLLFKVPEEDIREVSLRILQLYKRPKVNPEELESKVDALKKIYQANKHIQAQKDREAKAEEKKADSPAASTSKESKRDIKKEKSPKTPPLSKYHSSGHKKRERRSRSPYDRKRDYSSKRHKSRSRDRELDRSRERRMDDKRSRVMSRKYDDYDRAKSSRDGRDSRDEKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDX9</accession>
    <name>A0A0N0PDX9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03868</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ460144">
        <property type="protein sequence ID" value="KPJ17458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDX9"/>
    <dbReference type="FunCoup" id="A0A0N0PDX9">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDX9"/>
    <dbReference type="InParanoid" id="A0A0N0PDX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ17458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="411" mass="47520" checksum="A928113439E21FBD" modified="2015-12-09" version="1">MLYLLALVTVLAGLLHYYFTRTFDYWKKRNVAGPKPVPIFGNLKDSVLRRKPQVMVYKSIYDEFPNEKVVGIYRMTTPSVLLRDLDIIKHVLIKDFESFADRGVEFSLDGLGANIFHADGDRWRSLRNRFTPLFTSGKLKTMLPLMSQVGDKFIKCIDEVSQTQPEQSIHTLVQKFTMTNIAACVFGLNLDEGMLKTLEELDKHIFTVNYSAELDMMYPGILKKLNGSLFPRVVTKFFDNLTKNVLEMRKGTPSYQKDMIDLIQELREKKTLELSRKHENEDVKTLELTDGVISAQMFIFYMAGYETSATTMTYLFYELAQNPDIQDKLIAEIDDVLSRHDGNITYECLSEMKYLSKVFDETLRKYPVADFTQRNAKTDYVFPGTDITIKKGQTIIVSTWGIQWVEVFIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEJ3</accession>
    <name>A0A0N0PEJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox protein orthopedia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEJ3"/>
    <dbReference type="STRING" id="76193.A0A0N0PEJ3"/>
    <dbReference type="InParanoid" id="A0A0N0PEJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="208" mass="21634" checksum="5932FE6FE198EC2F" modified="2015-12-09" version="1">MYVVVLSHTRLHVVDLLPRLQVWFQNRRAKWKKRKKSTNVFRSPGALLPSHGLPPFGAPDVCGAGVFADRPWSMPSGLGQLSQSGVSMGVGVSGFGSGALPQLAADLAPSQQYQHYPLNSIGDSMMSYCGGGGGGAGGGGNGGALDGSPASPHAHCNTASPGTPGGGECEEQSWRGHSIAALRRRASELSAAIPPYLQLNYDAHSPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF98</accession>
    <name>A0A0N0PF98_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01013315">
        <property type="protein sequence ID" value="KPJ21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF98"/>
    <dbReference type="InParanoid" id="A0A0N0PF98"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="23645" checksum="B67005E987AAC9D5" modified="2015-12-09" version="1">MSWHRNGYKTFFELLLNTYKGGPGLANLNIKLNTEVTKITWPQKPLTPVEVTCKNGEVYRANNVIVTVSIGVLKERYMTLFVPSLPEEKALAIQRLSMGVVDKVVISYLNKWWPNSNVYWFNQTKQERDRAVKDNGWVTYFASVPFGSGNTITLWYSGDAAKLVSIVFFLFLYQRGFMDFNNFGPIINHLTYIIYSDNSISGFKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFM0</accession>
    <name>A0A0N0PFM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01016049">
        <property type="protein sequence ID" value="KPJ21032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFM0"/>
    <dbReference type="InParanoid" id="A0A0N0PFM0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11562" checksum="E4677B21F9A49587" modified="2015-12-09" version="1">MTAVIACPQEWRETHQYWGGPDCALIQLYPTFAVIEHAPKMLYLNTSIRGYPHGLRAGSDPRKPLLSVNADFDSFTFQGVPYTIQAIEVVLLYYLPTDQCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFS2</accession>
    <name>A0A0N0PFS2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Interference hedgehog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01057511">
        <property type="protein sequence ID" value="KPJ21581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFS2"/>
    <dbReference type="STRING" id="76193.A0A0N0PFS2"/>
    <dbReference type="InParanoid" id="A0A0N0PFS2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8713" checksum="57CD8D08CEB79898" modified="2015-12-09" version="1">MIPPSRPNVTRMSDESVMVSWSNAKEGLPIQFFKVQYKEVSNSSNSSGQWHTANYDIPSYIHAFEIDGLLPDKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I672</accession>
    <name>A0A0N1I672_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I672"/>
    <dbReference type="STRING" id="76193.A0A0N1I672"/>
    <dbReference type="InParanoid" id="A0A0N1I672"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="51709" checksum="54B887D016E6771E" modified="2015-12-09" version="1">MTETTLVKVKTERPDEAEIRELAAKMVEANKAKALAASAAVPRPPPGLAGAAPVGPGGQMGILNYLNRKNGVSIELQRPTSDDKKTPAPDEASYKGHFGWDMLGKCHIPYIYRSGEKYVAVRMVEIKLLNKYLNYLHADIYSCTCIRSYYITEVEARLLNEINTRHCDGQFGRDAFTQKDLVVRLSDAYEFYNFLDVCYNKLLRGTTNNKDKCGFIRINKESVVPYTVRDNQKFVPLFYFEGETDNLKLKADQLKGWDLSYLKFCCKVQGIRNELFASETCSVISLTDIKSYFPPGTEFEEYWPNKVVESQLLISAKGSASGGGQWTRAPPAPPPGASASAHSAGGVGGAGAAAAMGGARGRRPQARHSPAAAAAALQLPHGGITAAAVQALANNWNLPAALSQAQTQQVLRLAQAQVAAQAQAAARYNLAASMPQHRSQHQRNVQFPNSSITMAMAQQPPPPLVRSTANTTTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6Y4</accession>
    <name>A0A0N1I6Y4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461131">
        <property type="protein sequence ID" value="KPJ08902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6Y4"/>
    <dbReference type="InParanoid" id="A0A0N1I6Y4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="53" mass="6302" checksum="F666F499FE5DD0A7" modified="2015-12-09" version="1">MATARFHREIRSWWVTLMPLVGSLCNFHRFRRPFCATEEFSSANSLNEKIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I906</accession>
    <name>A0A0N1I906_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I906"/>
    <dbReference type="InParanoid" id="A0A0N1I906"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7843" checksum="926C9346D572915A" modified="2015-12-09" version="1">MLNGYSFTNPSPMTGGERWYCSGRLRWNCNVCLHVNDDYELVCIANEHGHSPPIYEKTDDGLYVEIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I952</accession>
    <name>A0A0N1I952_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein D-ETS-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I952"/>
    <dbReference type="STRING" id="76193.A0A0N1I952"/>
    <dbReference type="InParanoid" id="A0A0N1I952"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF305">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="15436" checksum="19776D024FD6EDCA" modified="2015-12-09" version="1">MANCSTGASGVGGGQVQLWQFLLEELAAGAPGICWEGAPGEGEFRLADPDEVARRWGRRKQKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYRFCWAGLAAACQAQTGDASPYWRCPPPHQPDWPPPAPPPPPPAPGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAJ9</accession>
    <name>A0A0N1IAJ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 9"/>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAJ9"/>
    <dbReference type="FunCoup" id="A0A0N1IAJ9">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IAJ9"/>
    <dbReference type="InParanoid" id="A0A0N1IAJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="13">
        <location>
            <begin position="474"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="590"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="925"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="927"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1015" mass="116755" checksum="2E76DE20AF40B6F6" modified="2015-12-09" version="1">MTKKFEFNWQIPVPEPLLQGAVFDRWTEEKDNTELEQNCLFKVDEYGFFIYWKSEGKDGDVIELCQVSDVRSGGVPKPESKLSTNLFNKHGETLEDKSLTICSGTDYININYQHVVCPDAATAKVWLDGLRKITHNVKANNVCPMTCLKKHWMRLCFLTDPRGKVPVKVVARTFASGKTEKLVYQCLSELGLPSGKNEAMEKEAFTFDKFYALYHKICPRNDIEELFRSITQGKSDRINLDQFVNFLNEKQRDPRLNEILYPLYDDKRALEIITDYEQNEEAKNDKCLTKDGLIRYLMSDENAPVFLDRLDQYMDMDQPLAHYYINSSHNTYLSGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDEEPIITHGMAMCTDILFRDVIYALRDTAFVTSDCPVILSFENHCCKAQQYKLAKYCDEILGDLLLKEPLPDHPPEEVVAEAAAAGEEAPPPVAYTGSTTNVHPWLSSMVNYAQPIKFQGFEEAEKKNIYHNMSSFAETTGMNYLKSQAMDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQTSDLPMQLNQGKFEYNGNCGYLLKPDFMRRADRSFDPFADAPVDGVIAAQCSVQVIAGQFLSDKKVGTYVEVDMYGLPSDTIRKEFRTRMVPANGLNPVYNEEPFLFRKVVLPDLAVLRFGVYDESGKLLGQRILPLDGLQAGYRHISLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAALSDPRAFMGAAKERTDNMKAMGIEESAPEKKVTIEEKKEEPPLVFEPITVESLRQEKGFLKTGRKQQKELETMRKRHAKEKMAMQKQQCAALEKMIKGKNKEQLSGDAAFRTLVTEQSAAWSELVGRQRVEEWASARTRLHEQRDLLRKMMEQTQLAQMKQLEAKHDRELKEMNARQAKISMETSKEVANDKTLKTKQEKDRRLREKKQNNTKKFMDERKTQIIKHTREKEKLKGTHDKQLEELSKDVDNLIEMYKMEESEFEMATKTEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBX5</accession>
    <name>A0A0N1IBX5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative zinc transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461113">
        <property type="protein sequence ID" value="KPJ08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBX5"/>
    <dbReference type="STRING" id="76193.A0A0N1IBX5"/>
    <dbReference type="KEGG" id="pmac:106717386"/>
    <dbReference type="InParanoid" id="A0A0N1IBX5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="75"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="316" mass="34664" checksum="0E06A8CB657A3E2F" modified="2015-12-09" version="1">MSDEPEARMWDDEGTRYDSRSRGSYFESAFASTEHLDRAPLLSEETYSEVQTTSTEDHHCHWKPQNQPPSSVPQLLAALLLCAVFMVCELVGGYLAGSLSVMSDAAHMLSDCGGFALALFAFRCARRPPNATMSYGYRRAEVLGAMASVLLIWALTGIFVYVAALRIHTGEYSIEPDMMMIVSGCGVAFNVVLALVLHGCASDIAHYHSHGGAACGHTHAHTHSQEQRPRIAFRMFRRSKHNGLVNGDYSLKDMATVEADVNARTKNINLRAALIHVIGDLIQSCGVLLASVLIKFYNTILGIAAHKQAEYCAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBX7</accession>
    <name>A0A0N1IBX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBX7"/>
    <dbReference type="STRING" id="76193.A0A0N1IBX7"/>
    <dbReference type="InParanoid" id="A0A0N1IBX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="390" mass="43618" checksum="5603F9C79DCA5794" modified="2015-12-09" version="1">MALQLSRREVDDLRSSLDRAIYRTIGKSDSSLLSTVASCLTNGYERRKIIDKISSHIDTKKASKLADKVLALAQELISNSKTSKRKYESSSDKDRDTKRSRHDEKEIKEEKRESKIEKERQEKEDEKKVGNGMELPIILPEGETVGSKMAGLSADKIKLMMANAQKEIEERKRALLALKGEQRPSVNAAVAAAQQLKVQMQQNNAIPPPSVIKPVLYSRPSAAQLSQEELEKQRKIAELQARIQRKLAGGALASAGNAGPAPLILDREGRTVDTSGKRVQLTHVAPTLKANIRALRREEFKAQLSSGSASSVPAASAPWYDDRVESKPPVRARRALRFNEPGKFRHLADRLRMKVLGTNPDFYQCVFRFTYVHLSNILTVKEKHRDAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICP6</accession>
    <name>A0A0N1ICP6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SMG7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICP6"/>
    <dbReference type="STRING" id="76193.A0A0N1ICP6"/>
    <dbReference type="InParanoid" id="A0A0N1ICP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF5">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="960" mass="106448" checksum="627A5D47BA947D06" modified="2015-12-09" version="1">MVLNAAVQMLREADELKQKILKFNSGTSMLQDRSLWTTQQQLQNVYQKILMLDLDYALDKKVEQDLWNVGFKQQIEALQAISKDRKNPLRSEGQAMLSWVLQAAAGFYLCLLHQICATFKLDLPFRRRASLLGSVEAWGPGASAAPAAARYASQHCLVHLGDLARYRQQLRVAHTFYRHALAVSPHSGQPYNQLALVAWRRGRRLAAVYWHVRSLLVRAPFPPAPVNLARTLEAARTSTKGQMSCVLIWLVQSSSEDLSSESALSADEAVAARLAASLAANTVLALLLPAYTAPEPPKKALPALKVWLQWAAARGRGRGRGGALQGAAWSARPQLWPALAHTLTALLPRAAALPADLYDTVPLPEDEELHGFLPLEEAFQGLKFSYHTTWDTYGGRLPDIDTGQDGDTGSPSSIAASCFSSEPELEDKVRAHRLVALGKQLAEQHAEHFTCETEEDGTVRFSASAVGGEQLRRALAELSAAAEQGAGPGAAEGGADDSEDEAPPPAPPIIISEADFREKVREKRVGILKPQGSLERAREERAREERATVHEEHLPLVHDLEIDEESSKSEDKKEGRKARVNIAMAAIMRKQEETNKQVKFASPPPTPDSLTEGSESGAKEAEKLKVLQPKAIKSLSNLPLGRKTGGILSLKDKSAGYPHLVNTDPEPPKKTEKDEKKDPKPNNNTNQNSQQSYQQKWQDHPPQNWPVQPQPFSEPRVAFQKTYGIQSAGLSYNPNYQSAPGFGQGIRLPVVNPKEIDVRTAALQKQNSRPEIFQEGHKFTNHGYQMSSDKKNFLNDLPPRFANQYRYWHNTQETQPNENKFRDENFTNNATFESQPLRSWPTPQPEYPQPMTWWKPENSQVFNANFSAPMNVQPNFYSPSPISSNTQNPYLNLTYNQNQAQKPDSVNPNWQATIGQPQMPTLQNLVTSPNFSGALNNFGSYGAGVGYDAAMYPQFANKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID65</accession>
    <name>A0A0N1ID65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_00785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01063757">
        <property type="protein sequence ID" value="KPJ21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID65"/>
    <dbReference type="STRING" id="76193.A0A0N1ID65"/>
    <dbReference type="InParanoid" id="A0A0N1ID65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="194" mass="21919" checksum="A0AC2876CD5E5863" modified="2015-12-09" version="1">MKSRFFLCYQIVDPSATKPEDWDEEAPAQIVDPNAVKPDGWLDDAPEMIPDPEAKKPSDWDEEMDGEWEAPLVDNPACAAAPGCGPWSPPLIPNPNYKGVWRAPLIPNPNYRGKWSPRRIPNPHYFYDENPFKMTPIHAVGFELWSMSPMLLFDNLIISDDMEAVTDWTQQTYSLKRAKISSESVSTPSLAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDI3</accession>
    <name>A0A0N1IDI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460736">
        <property type="protein sequence ID" value="KPJ12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDI3"/>
    <dbReference type="STRING" id="76193.A0A0N1IDI3"/>
    <dbReference type="InParanoid" id="A0A0N1IDI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF4">
        <property type="entry name" value="FAM193 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113832" checksum="7C7B0D2D55A5D971" modified="2015-12-09" version="1">MPELQQPPPSPEKKPEPIYDLPIHNKPTLTPQQQELIRQQQLQQQHQQHQRQLLSQQQQQMHQQQLQQHQQLKQIQQQQQQHLQQQMQQRQGRQQQQRATVSLSSRDTSVFSTSSGCSGGSFWRCGRAEDPRDLDALLQYIEGPQRHVDRGKKKAKKQRQRAKKVTEDKQKLNPAVQAKVQLLTEQLTQINTFISTTTEDVPDQQLDLQLRNFQKLKEVAKALGGGDGCGVVRVRRAGSDGVTLSVDGRDDVPLSHLLQATNTQLADEKPRDETTPQTKDQPQRKQTWEQALAHINQIAKGTNKEKKKQKETQAVKAEVKTKEQKKTQSEPEPTALSKKQRKLLAKQQAEEEEKKKQQQQAEAKKKEKKAEPPKPEPVSKKVEKKPTASEIKAEEKAKKKECKKQEKMEKKGKEKQEKTAQPVKQKQPQPPAQKKEKEKKKEQEPTAKQQAIQKSKVVTPDTTLEVVNNKSPCPSETEKPASCSIMEQLSSGVQVADLKLPPGITLTRVQPNEKKDTPPPLNSVPLWRCSELTAQPTPPPRPPPLINADPAHAVFTTHMPEPPKTIIVPDPPPAPQNNAGKSKKSKKKGKKSTDNEIKQDGAKMVTLRNPMFHPNLPTVQITNAPPKKTEIRIPEPIPMPPTACQATITPTSNGMYTIRNPLMSIMHQQSLMGIRNPVPQNNHTLFTQPPYTYVNPNVYNPVQNQNQYVMEPSRNSPKNQENDLNNRILNLASFTKKSDEGYSLFSTPEDTNQRSFLSPVYYEEKSKPVVSPNPIGTRPNTDRTFENESLFANPIQRPEPIGTPRNDDFKGSLYTPFGQEDRNVFRSALFSDNSVASSNVLNTQDVGVPHLSNGDSLPYFQRLRVGSKLNSEVTIHHVTESKFYKQDGPQDEVRGDESLFSRRSPPAWPDTLYAHNHTGISSPISQGECDNGAISPSPPNDDGPGAIGEGAPHSRHESSVFLPDRTITNLSALEAAEREIESFKRFDFYFEPPQHKPRVALDVNALRPGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEL8</accession>
    <name>A0A0N1IEL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane and TPR repeat-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050186">
        <property type="protein sequence ID" value="KPJ21477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEL8"/>
    <dbReference type="STRING" id="76193.A0A0N1IEL8"/>
    <dbReference type="InParanoid" id="A0A0N1IEL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="5">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="78" mass="9003" checksum="547432AFD611EAF0" modified="2015-12-09" version="1">MGGMKPEFKPGDNPAAFANNTFTKVATFHYIYFLNFLILLWPQWLCYDWSMGCLKLIEKTCADHHLLLRGDTVSALIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFL9</accession>
    <name>A0A0N1IFL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFL9"/>
    <dbReference type="InParanoid" id="A0A0N1IFL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="23954" checksum="F5AF8B2DAC8BF4E4" modified="2015-12-09" version="1">MYDFDSNNKVPGIYWLKQPIDDLKIKITIKPQTTAINLPKYEEFMNISTTADLEKIDNNKNEEYIFKWQEKVFSTWEINNYSEIHNCITETQLDHHNTLNSIVYKPQKVFTYIHKDYYLPLPLDLKKTQYQTDNFNLLLCFENLNLDGRFSGSFGGTSSMRQLYRSEDSMIEKSSWIAMHVVFDNSKYTDNSIRTELKNKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGJ8</accession>
    <name>A0A0N1IGJ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Huntingtin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460794">
        <property type="protein sequence ID" value="KPJ12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGJ8"/>
    <dbReference type="STRING" id="76193.A0A0N1IGJ8"/>
    <dbReference type="InParanoid" id="A0A0N1IGJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="779" mass="87338" checksum="41FC7EFB713BE3DB" modified="2015-12-09" version="1">MNVLEKAEKSLEFLKSGEGSAKSHELQAAAGTLGRCLGALGSRPNCARHYANFLHSAVPIFLSLASNDSAEVRLVGDEALNRSVAGGFAFHSYKTNIILQNQIDHNKNARWIRAALSRICLGDCWLRPGVGKIRTQAQTLFPKLSQIVQHTNEIQLIVEALEFNLPRILNALAEYTTDEEISELSKALLSHVDCSEVSVRRGIANCVAHLTSHREPLLTNILNKVFENLWPAAASDTSIVGWFCVVKAMFQINDMEKFTDNDLFSVQDYLELYNLCIYYLEQTTIEHNVQNSVMECLSVLLSQVNVDQRKALLEKHPRLVCLDDRKSEKGHRRNISSVSAVSCRSAPSPLTEGRDLDVLVRGALQLGSLLQLTTPSLSVEDLTIQVSTSRCEKNLLLEKLEEMDITDHCDDDVQISHETSFKINIGSSTDDDVVLKYCARLLVSKFLLTGNKGVFIPDRSVRVSVKASALTCLSEILRVYPQIMTMYLDKDADIKLQNYSGSSEGVNFCQDNEFILERNVCYQDSITESISQELSHKSTDSHTNTQTQQTSKKSTDKTDSPDRKSSKDTPLNLQDIRLLGKMDLIASGISADSTNANMTNSNFTSNSNMTGSNDPISSGYPMSSSGDVLSSSIDLDMKFDHFGESNTNLDNLDSLKDLERKEDRKKMKRNEVCQEKEKIEDDKSEKEFEFQHMCDLFVLEGHSDPQIRGLVRVCIGNYLISALDLSHGDYNRWRCYTNMTKDNADCLCIDKLMDILMKVSFKLRLKVCKMKLIKGFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH47</accession>
    <name>A0A0N1IH47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH47"/>
    <dbReference type="FunCoup" id="A0A0N1IH47">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IH47"/>
    <dbReference type="KEGG" id="pmac:106712704"/>
    <dbReference type="InParanoid" id="A0A0N1IH47"/>
    <dbReference type="OMA" id="GQRDGIN"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="24094" checksum="5E53A5C993DC8936" modified="2015-12-09" version="1">MVIYGVYIVSKSGGLIYNYDHNIPKVETEKTFGYPLDIKLQYENKKVVVVFGQRDGINVGHMLLSVNGSPVAGRTTEDGRDVFDLIEAKENYPLSLKFGRARATTNEKIVLASMFYPLFALASQLSPVPKSSGIELLTADTFKLACFQTLTGVKFIVVTEPGMAGAEAVLKRIYELYSDYALKNPFYSLEMPIRCELFDTSLHTLLELVEKSGTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIB2</accession>
    <name>A0A0N1IIB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interleukin enhancer-binding factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460301">
        <property type="protein sequence ID" value="KPJ16132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIB2"/>
    <dbReference type="FunCoup" id="A0A0N1IIB2">
        <property type="interactions" value="1555"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IIB2"/>
    <dbReference type="InParanoid" id="A0A0N1IIB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="6">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="22496" checksum="F5B8F196DB980072" modified="2015-12-09" version="1">MVRGVGRGGRGMPGRGGMGRPPFNRPRVMLLRPPFDLILAEPAFPRCKPAPDDSALTQALLKRHAELCPTPSEQASVLSLVTKLQTVLDNLVVAPGDFAACVNEEVNKLTRAMGTGSVTCACNERGFTVTAAGAAVRVLVTTLHQNLRKLEPEVHLEYKVISSHLAAIRHSRWFEENAHHSSVKTMFYICDKFLQHLLNRSGDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIT5</accession>
    <name>A0A0N1IIT5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Box C/D snoRNA protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIT5"/>
    <dbReference type="FunCoup" id="A0A0N1IIT5">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IIT5"/>
    <dbReference type="InParanoid" id="A0A0N1IIT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="3">
        <location>
            <begin position="47"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="35141" checksum="6C11074767D077C4" modified="2015-12-09" version="1">MKDFTDTDLLSDYRLLEECARFVYAVRRDEKKKFTRIDKDLPIHLFKLKMAARNRGIALQFLAQNFTRHSVNTTRYHYKTNIISWRVEWIFPNVDTKPLKFVDEKCPEQNKLSRLLDKYLNPNASPFEGSKSLAFYKSAGFSGIKILLKAEKIRGSAKKFFELDPTETLGENLSGKCIVEFPIIFIVLKDHACNFEIITPEDEFESNMKEHDERENIENDVKSKKNESGLEKARQNINEQRKRPRQLLTEKVAQQKKMEIEKEIREEKKKRPKNLLFTTGYSSEESIVSSDSENESSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJI4</accession>
    <name>A0A0N1IJI4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJI4"/>
    <dbReference type="STRING" id="76193.A0A0N1IJI4"/>
    <dbReference type="InParanoid" id="A0A0N1IJI4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="64247" checksum="24126BB895824488" modified="2015-12-09" version="1">MKTTETIIHETEDITVTYQTEKWAIEEREFYTAFEETTCNDLGPIIIINPVPMYKYLKSWNTSSFTDNDCAKVYPLDTYLEFSCEDIVTSCKKIEATGILKSSPSTSPNTDNTLLTATHVLIAIGSVASVTLVSYAGYCISQKIIDIIQSNTYRGVVPWWRGDVGMGAVLPLALAAVLAAVSGARALPADPKTTAPPVSLTTPRTTQTTGPAPPAQHAQPLLEEEEDLPHLDYYDEERINISQKGMYLGSPCDSSCSPKLVHVYCEPSTLSCQCDPKHPVALGPTKGCARPKKLGEQCFYRQTCRAFDPHASCVQVNHNAYCQCEPGYHSTTHTRPVPRLFCTEDMVLLTADMPTLLGVASGIFVLAGLLCMVLHLYTRARYHPAHLADARLTPPCLYSLNDTGGTLSATRASSRASSRSGCTSGCTSGTLEGGRGRGIGASRAGAARAAAILLISRHLKPVRDGGAHPPKCAAKGEPDDVCSAQLYCSSRRPSLNSVQSSSSSIRSYSAKRWEREREQKERRQMSMRLAQLHDKMAAGREPPRHAPTPSPRSPNNSTDGLLPAVCEIRELITNSEQQLQGVDGPCSSSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IK33</accession>
    <name>A0A0N1IK33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin-XVIIIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459707">
        <property type="protein sequence ID" value="KPJ20332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IK33"/>
    <dbReference type="STRING" id="76193.A0A0N1IK33"/>
    <dbReference type="InParanoid" id="A0A0N1IK33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="36495" checksum="AC17C12A32C2FCF3" modified="2015-12-09" version="1">MIITSFVINASERLELELLHWRSAENGVEPSDSEGSEAESGIGSDKYKRRYEQAHRELQLLRAQLRRQHEDDLEQLVTVKKQLEKKVQDAYEEVEEQRAVAAGWKRKLQKLTNDMADLRSLLDEQTCRNNLLEKRQRKFDAELQAANEELKRERATRERHARDRDQALADKYALEQTLSEARLELELKEERLSAATRELEERGGGGDELAALRRARADLERRVRDQEEELDDLAGQIQELESSLELEATSRARVEGQLARLRDAHDALAAELGAARARDMHAADELRKLQRSIRYITILQLLSFIHYILQISTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IL32</accession>
    <name>A0A0N1IL32_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01057229">
        <property type="protein sequence ID" value="KPJ21575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IL32"/>
    <dbReference type="InParanoid" id="A0A0N1IL32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7531" checksum="68DCBC71EF40AF43" modified="2015-12-09" version="1">MGSPVFNYMASNTIKTPPVGQPPYQVSIEERMRWAQIAEAMAQANHYAVRLFIYKSIAPTNKGQCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INR5</accession>
    <name>A0A0N1INR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INR5"/>
    <dbReference type="STRING" id="76193.A0A0N1INR5"/>
    <dbReference type="InParanoid" id="A0A0N1INR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="86" mass="9495" checksum="3A0817176A528188" modified="2015-12-09" version="1">MAAGLVTIAHRSGGPLLDIIQSSPVRTGFLAAEPEEYARAILEVVALTTENRRKMIEAARDSVDRFSSVEFEKAFIRVTEPLFVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPJ0</accession>
    <name>A0A0N1IPJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPJ0"/>
    <dbReference type="STRING" id="76193.A0A0N1IPJ0"/>
    <dbReference type="InParanoid" id="A0A0N1IPJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874206" evidence="9">
        <location>
            <begin position="21"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="10">
        <location>
            <begin position="56"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="568" mass="64800" checksum="59F1E1F30F9BD9C5" modified="2015-12-09" version="1">MRTLACVLCWLSGLSGPVDAHSEDFLSRAYENRTEPDSRQLYDFRKTHPKPIGLFALSSGYPVEIRETNALNSDLLMNRFFLDNILHFVSERIPERVAAAKGTAALGYFEVTNDVSQYTKAEVFTGVGKRTPVAVRFSTTVQNRGGVDAAREPKGMAVKFYSKEGNLDLLCLNAPVYFYKDPEYFFSVVHGTRRNPRTDLFDRTMRGDMFTLRFDAINAFLRLLSDSGIPNGFRKMDEFPIHTFEIYNAQGEKYFVKFNFRTLQGIENLPSDEATRLNGQDPDYFVRDLYNAIAEKRYPMWRLDMDVLTFEDLLHLDFDPFDVTRLWKKGTYRTVTVGRLVLDKNPDNSHRVAEQLAFNPANLVPGIAGPKDLLFRGRSLAYPATQNHRLGSNHNKIEINRPLYEKNYNRDGDPPERDNMKDAPSYYPNSFSGPVPYVDAARPKEQIMVYESNAVDLEDPAYFYNHILQTDDERDRLANNTVDFSLLTAPPFLQRRVIKLFSWISPDLGRRVAQKLRQRLAAPPPPPPRVLRAARCSAAGDERVTVTATTRTSHTQNISSIIELSIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPZ8</accession>
    <name>A0A0N1IPZ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Facilitated trehalose transporter Tret1-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPZ8"/>
    <dbReference type="InParanoid" id="A0A0N1IPZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="472" mass="51956" checksum="39676BC8568DB633" modified="2015-12-09" version="1">MTFSSGLTSGYSAILLPQLKEPDSVIPWDESTASFIRPDVWDSAILLPQLKEPDSVIPWDESTASWIAAMAALPMAPGCLLSGWMMEKFGRRNSHYIVCAPLLIGWILIACANNLLLMLIGRFLTGLCVGLLGPLGPVYIGETSEPKFRGIFLAAVSLAIAVGILVAHLIGTFISWQWTAVICCLFPILSVILLSTVPESPTWLICRGEVEKGVKSYYWLRGYSEEAKAELQAVIDKRKQTDSEPVPTWREKIVNLKSPELLKPLAIMIIFFITCQFSGVNAVAFYSIEIVEKAVGKGMDHYVAMLAIDVLRTVMSVVACVICKQYGRRPLCFISGIWTALSMIGLALFLYFTEGKPTDMSWLPLSCLMIYICAISIGLVPLPWMMCGEVFPTKVRGLGSGISSATTFLAFFVVVKTAPGMMSNLGEVFTFLFYGIVAFIGTVILYFILPETKGKSLQEIEDKFRGIKSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ17</accession>
    <name>A0A0N1IQ17_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459900">
        <property type="protein sequence ID" value="KPJ19350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ17"/>
    <dbReference type="FunCoup" id="A0A0N1IQ17">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719179"/>
    <dbReference type="InParanoid" id="A0A0N1IQ17"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="47365" checksum="0D33C44249406CC7" modified="2015-12-09" version="1">MLKRLLDKLESERMPLLGPNVKALKFWGLLLPKKMLPRNLYMLLHLLVIIFTATEYVDIWFIKSDINLLLNNLKITMLATVSVIKVMTFLFWQKHWKSIIQYVNKADLAQRITDNRIKKLTIEKYTRYCRRITYLYWALMYTTVIIVMVQPIYKYAALPTYRELVRNGSQPYMQVVSSWVPFNKNTIPGHITASFIQSFASIYGGGWITSFDTNAMVIMVFFKGELELLKIDCGDIFGTESNPVSDNVANIRLHNCHKRYVELIKYIRLFDSCLSPIMLLYMFVSSVMLCATAYQITVETSAMQRFLTTEYLIFGVAQLFIYCWHSNDLFYASRQLINGPYNSMWWNRNKYCQKDIQLLIGQFNKTIVFSAGPFTDLTVATFINILKGAYSYYTLLQQSQETTVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ37</accession>
    <name>A0A0N1IQ37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459836">
        <property type="protein sequence ID" value="KPJ19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ37"/>
    <dbReference type="InParanoid" id="A0A0N1IQ37"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874112" evidence="1">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="251" mass="27861" checksum="6FD45F6D99D23252" modified="2015-12-09" version="1">MFKTLFLLLVPSALVNACYTKQITILSDFSNEDDINFFKSTLPWIVDNIGNVLKIRYHFKDSDGAKECVLEQMKGNTYFQVSYLSKIAQGMPTRDAVGSCKINDRKLQQCLKRKVRNFIKKANREFSKVKSETTPVILLPGKKEISGNDPEIVLKSICILFGRNQPFGCLNPKDFPTSTNQNKNPNTTIPAESTVNVETNITTETRSSIETTITEAKTAGISITEAAKTIVTDSTSVETTPTTTTTVSDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ85</accession>
    <name>A0A0N1IQ85_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KQ459928">
        <property type="protein sequence ID" value="KPJ19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ85"/>
    <dbReference type="FunCoup" id="A0A0N1IQ85">
        <property type="interactions" value="1734"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ85"/>
    <dbReference type="KEGG" id="pmac:106719717"/>
    <dbReference type="InParanoid" id="A0A0N1IQ85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="409" mass="46892" checksum="4443D1E13B97D4F7" modified="2015-12-09" version="1">MAAARGLKTLQVVALILFVRILSVLFVQTWYVPDEYWQSLEVAHKQVFGYGALTWEWQKGIRSYLYPSLFAALYAVLKFTGLDSPEAVVLVPRLFQAVISTAADYSFYKWTGGRKWALFLILTPSFWFYTSGRTLLQTMETCLVAIALSVYPFKDGALARYEKENNKWVWLACISTFLRPTSAPIWLVLALYNINTTNQGKLKLLAGTYLPIGFIPHKEFRFVLPLLPILLYLAQNVIVPWSRKAKAWKLYLVATVLLLGNAVPAIYLGQTHQKGTVQVMPLLREAIGSNNRSSILFMMPCHSTPLYSHLHLNITTRYLHCDPPSPGETYESEAFYNNPQRWWRQEYSARQTPSLIVMFDVLRGRVENLLQGYKLIYEVPHTQYPEGEVGEKVLVFQKNVQMKQTDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG22</accession>
    <name>A0A0N1PG22_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG22"/>
    <dbReference type="InParanoid" id="A0A0N1PG22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="8681" checksum="91D93EF057B4C8FB" modified="2015-12-09" version="1">MSEKVGLRALEPPRGALAPSETIGPYTNELTLDADDIKAIMSGEKLKRERQNRQTSKEPASAPAPASPGPAGLLGAPPPAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGR7</accession>
    <name>A0A0N1PGR7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dual specificity protein phosphatase 23</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Low molecular mass dual specificity phosphatase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_02655</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGR7"/>
    <dbReference type="STRING" id="76193.A0A0N1PGR7"/>
    <dbReference type="InParanoid" id="A0A0N1PGR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14504">
        <property type="entry name" value="DUSP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000063">
        <property type="entry name" value="Dual specificity phosphatase 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="50"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="31480" checksum="2E60DF65EFF18D28" modified="2015-12-09" version="1">MSTVTKRTNVKLAKLFYKYADAAIKEKTEEIKEEKPVEEKKECESYPPYNFSWFVKGKVAAMGWPQTIENLNYLVDSGINHLITLSPEKLPPIYDFDRKLKWTEIGIKEFGAPTLKQIIKFIEICERAEINGEVIGVHCRHGRGRTGTMLACYLVHFKNMAPERAVLTVRVQRPGSCETYEQEKIVCHYHDCVRGTITKPDYRLVDDKVYFDCTMKYTYPDEEVIHKDDVQSDIDVPEITFEKLDVEEIIERHSNEKKSKAMVINHKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGW9</accession>
    <name>A0A0N1PGW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGW9"/>
    <dbReference type="InParanoid" id="A0A0N1PGW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="16749" checksum="243CFC7DC4036905" modified="2015-12-09" version="1">MPDLDPFDIIHPDCVTCCDNIEKSKRIQYANEARDYMNACVTKNKTLPSHIVNLVDKDVETCRKKQSSDDNEELRRRAFALYKNYVEGRKEGGKCPTKKGAGREIADMYLKHPGNESSSDEEGTETGVIEGTSIQNCKEDIVRRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI77</accession>
    <name>A0A0N1PI77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="14" type="ORF">RR48_02285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460497">
        <property type="protein sequence ID" value="KPJ14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI77"/>
    <dbReference type="STRING" id="76193.A0A0N1PI77"/>
    <dbReference type="InParanoid" id="A0A0N1PI77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF40">
        <property type="entry name" value="INNEXIN SHAKING-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="232" mass="24920" checksum="CE906D17DDD0648C" modified="2015-12-09" version="1">MGKTSGGRPDAGVRALRINNRRESGVSWGRRGWGARGGARGPGSAGVAGAGRRRERGGQPRRPMDILTSIYALLSGGVPAENQRRGSLVCPCFAELVPFCHTLCLQGVNPKIDSVAFRLHCGATTAALLAASAALTTRHLVGNPIDCIHTRDIPEDVLNTYCWIHSTFTVAGEAAGGAYPGVRSAGSAPRRYGKYYQWVAFTLFFQVSYFLGLSHIILRLVKLCYVILTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIK8</accession>
    <name>A0A0N1PIK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIK8"/>
    <dbReference type="InParanoid" id="A0A0N1PIK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12794" checksum="5806E2C559988525" modified="2015-12-09" version="1">MEFYSERRWPNNVVPYYIKNSLKYYDLDKVRQRLNEVNHILKTETCVHIKEISEKDVSKYQDYLILDQSPDYVTGRVGGKQVRIVYQINPNKLRQNKISSNIRNANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIX3</accession>
    <name>A0A0N1PIX3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inhibin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIX3"/>
    <dbReference type="STRING" id="76193.A0A0N1PIX3"/>
    <dbReference type="KEGG" id="pmac:106711986"/>
    <dbReference type="InParanoid" id="A0A0N1PIX3"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="7">
        <location>
            <begin position="137"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="242" mass="26498" checksum="BB0D6365283059F4" modified="2015-12-09" version="1">MISVAGETLNGQRLIEFRLGHEAESEQGLAVERAELLVRAEVRSRRPRFTLWAFTVAGNGSETRVGPLAGAARGAGRAWQRLDVTRAARQWAARGARAPLRLLLDCSGCAGRVRLRLGGAAAARPLLRLTLAARAARRRRALDCDAAARGGCCRQTYYVSFRALGWDDWIVAPEGYYANYCRGACAPFLNYHAQVVEAARLERAACCAPVRFSALSLIYFGADSNIIKRDLPEMVVEECDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK04</accession>
    <name>A0A0N1PK04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01061467">
        <property type="protein sequence ID" value="KPJ21620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK04"/>
    <dbReference type="InParanoid" id="A0A0N1PK04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="13554" checksum="CAB309C883C99F3B" modified="2015-12-09" version="1">MSFKILIVTLFFSDETKEIWSAIGTLLQDGTLLNNYDKVFDDIAGSLTRRLGELRHLENALNDEISTELYRWALEMLGAMLFGIRLGCLDGPAHVPTDENRYCISDIDSRVNCNRNQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKH3</accession>
    <name>A0A194QKH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKH3"/>
    <dbReference type="InParanoid" id="A0A194QKH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264409" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55128" checksum="AFC95DDDCACB158B" modified="2016-10-05" version="1">MKFFVVVFCFSIVVCSSLRSVSEDEKSLILRDKRVSDDSSNTRQLIKELARKLSDSAQQAIEAVRNFTVGIKDEIQLYTEKIHADRQRLRRRIRGAIRKIPDQLLEAGEGITTCIDSHREEADNLIDETYARSRSCADDRIKEVNDMIDELMTESNSALNYSKNILESMRNCSIDDNGSILNVGQCLSPLTNEAQAAGAIFTSNSGISITRINLAIGTLPAAFEMCAGFNMIRATIGTAKIIIDIGRCSATSDVYSVLSNEHNVDNILTIQRTSENQRSLADLWNNVKQSAINAWESVKNIAKHTAERINIWIQKVKTKANEINSSFKSRLQDMKKEMNNLIASIKVSGILVKQCIKRQQKAIEKILKDILINVTACISQNTYYLPLLEETSKQLLTDKDEFIANIDKELQACLNHEDIDECFNDVRKKVYDDLENEEKDILKYRDATRAIADEILDTIVSCTSNGLIEASAAITNTTIQIIKCVSAIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKR2</accession>
    <name>A0A194QKR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKR2"/>
    <dbReference type="InParanoid" id="A0A194QKR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="7832" checksum="CA7603DDB330A128" modified="2016-10-05" version="1">MEPLSMHSLKSLVHEYGTRVAEAAGTGVQRVRGERPAMTSARPDAARLQLNPNYDLRRPWVELDASDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLC1</accession>
    <name>A0A194QLC1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ribosomal RNA methyltransferase NOP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLC1"/>
    <dbReference type="FunCoup" id="A0A194QLC1">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLC1"/>
    <dbReference type="InParanoid" id="A0A194QLC1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="331"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="626"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="423"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="840" mass="94966" checksum="28A9799D70D2885E" modified="2016-10-05" version="1">MGRKAKFDETKKVKKGPGRKARKQPDPIFRKELLEDESEEKKLSHRQKQRAARRLKKKAQLAEKRKAAKQAKKNVNQEEEKEMSVDDKSSDEEVKGGFTDDNKEWLTLKKPTKTKSKVDKPVSNSDEESGSELDSDSETKEDSDDNEEVEEDNEKESGRKENYKVGTLDDLFQDSDNENAGENGLESDDDAPKMTYDSDSSEGDGKDEGDDEEDDDDMLPIEKANLKLKKKQKLNQKLADEEMQLNIAKQDVFAFPTEEELQNPTSLQDIHQRIKDIVTVLGDFNRLKQEGKSRCEYTELLLKDLCTYYSYNEFLMEILMQIFPVQELVEFLEASEMSRPVTIRTNSLKTRRRDLAQALINRGVNLDPVGKWSKVGLVIYSSTVPIGATPEYLAGHYILQGASSFLPVMALAPQENERILDMCAAPGGKASHIAAIMKNTGALFANDANKDRTKAVVGNFHRLGVVNAVVCNYDGRQFPNVIKGFDRVLLDAPCTGTGVIAKDPSVKTTKDQKDIQRCFNLQRQLLLAAIDCCNAKSSTGGYIVYSTCSILPEENEWVVNHALKRRNVKLVPTGLDFGTEGFVKYRHHRFHPSLKLTRRFYPHTHNMDGFFVAKLKKFSNVIPEPFKDEDDEEELNDEKVATENGDASPSEQKEDQTNTTNGPLKRPAPSDTKEPQKKKKAKENSVETEEKAVVSSEGKKKKNKKNKQKGKALNEKRAQEKTTNVNEKVNDDKSDETDNGKNEKQQQESLPKDSVNTIVGTPSPKKKGKKNKKKKNQQSNPTVVSKNEQNVTEKVQLEVSKKLKNKMKKKKKIGQINNKNQNKEKKSVKPNQKFKTKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLQ7</accession>
    <name>A0A194QLQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OTU domain-containing protein 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLQ7"/>
    <dbReference type="FunCoup" id="A0A194QLQ7">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLQ7"/>
    <dbReference type="InParanoid" id="A0A194QLQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="140"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="288" mass="33659" checksum="654462F5FC2FD238" modified="2016-10-05" version="1">MADYIEENNEIEMLENKHKKEKKELQAHIQALKKVAKNDKTKKKELTAEIARLELELDSRQKKEIEAVSKELSIENGLEQTDESEEIKVKLSKAQKRRVKKEQQEREREQEIKLQKKENINGPRNLENKAICNRLKEINLQVYPISSDGDCLYKAVSHQLLIKRKQSISVEELRKQTSNYIRENKEDFMPFLSHPETCDMLTDGEFEEYCEKIINSKVWGGQIEIRALSNYLKCPISIIQATGPPSIEQGEEFEGPSLVITYHRHMYRLGAHYNSTLVIEDEHHNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMN6</accession>
    <name>A0A194QMN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminoacyl tRNA synthase complex-interacting multifunctional protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMN6"/>
    <dbReference type="STRING" id="76193.A0A194QMN6"/>
    <dbReference type="InParanoid" id="A0A194QMN6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="172" mass="19079" checksum="7B59CD20915A0602" modified="2016-10-05" version="1">MLNKISSNILANAETAEKRLADLRRKVEDIKKFKVEEKIQELIKENSVLSEKIIQAKNELIKLEISHGKKQYSVPSKEITKSNVVSICIEKPQDKSSEVENAQPTAPKKEKNSVKKIKEKVNPNPSTDNIIDMRGVTSEAMVMCASSPEKVEVLNPPSDAIPGEDLALLCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN71</accession>
    <name>A0A194QN71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN71"/>
    <dbReference type="STRING" id="76193.A0A194QN71"/>
    <dbReference type="InParanoid" id="A0A194QN71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="38460" checksum="D2DE5005D54194F3" modified="2016-10-05" version="1">MEPLSENGLCLSELELHGGHLHESVAASVGSAISSLMAPLHHEPQHAPLHHAPPLHHEPLEKLKRESFKSFIIHLRVYKEALAAGMEPLSENGLCLSELELHGGHLHESVAASVGSAISSLMAPLHHEPQHAPLHHAPPLHHEPLEKLKRRVTIAAGGEFVRSTRPEQIFVSLVRVAPEIIKFISSRLNLTDDTAPDKHPMLIHCALQAKLCTPHPACYMLYSARCTIHGRVTIAAGGEFVRSRRPEQIFVSLVRVAPEIIKFISSRLNLTDDTAPDKHPMLIHCALQAKLCTPHPACYMLYSARCTIHDINTMHLVHSRNLDQVIAPSCGRPTNCVDQAVAAILVLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR08</accession>
    <name>A0A194QR08_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">RR48_14408</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Ya'a_city_454_Pm</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR08"/>
    <dbReference type="InParanoid" id="A0A194QR08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="26" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1237"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1410"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1440"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1476"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1549"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1586"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1629"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="24">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="24">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="21">
        <location>
            <begin position="389"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="23">
        <location>
            <begin position="696"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="25">
        <location>
            <begin position="1282"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="22">
        <location>
            <begin position="1401"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1682"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1690"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KPJ05966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1701" mass="195940" checksum="AE5E7D276E1A364F" modified="2016-10-05" version="1">MALSTSRQQFLACETQGLDDIHYGRKGGIFISTCICISFVIFAVILAFIVGVIVYFVTYFKISQEAPHDFWDDTEPFGYTNAPSPDLRLPAYVYPSFYRLKLKTDIENSVFSGDVYITLRASKQVKEIILHSKGLSINKNARLTEQIYEQETINARKRRDISNITELTTVNTVSVPQNESENSVTKENKTDIFNHTTLNPLNNLELTVDTQVTHSSVRNIKILSIKESTGDRLILTLESPLKSGIDYILELSFAGNISNSMTGFYKSTYTTSKNEIKKLGVTQFEPTSARAAFPCFDEPAFKAKFEISISHLTNMTALSNMKVSAQENIEEEPGWQWTHFERSVNMSTYLVAYVISDFKYLETNYTSKDNITKSIKIWTRPELIHKAKYALSITPKLLEYYEDVFGLPYALEKLDLIAVPDFSSGAMENWGLITFRETTLLFDKDENVPRDKQSVAIDIAHELAHQWFGNLVTMKWWTDLWLNEGFATYIEYVGVDRIEPEWKMFESLTQDKMNLLKSDALKNTSPVSRKVIDASEISQKFDEISYMKGANLIRMLNHTITEELFHKGLETYLNNWKYSNAVENDLWEAMSEVIKNHSMFQHLSVVEFMNSWTRQAGYPVVNVERDYDKGKVTFTQKLFTSSGEPYKEMTDQLWHIPLSYATMDVPRANWTTRPKLWLTDRTATTDLHINDTQALYVNIDAIGYYRVNYDKRNWELLNQALKSNNFSNPLTKAQLIDDAFNFAKADQLEYSYALGLTTCVINGEDSKIVWDLLLNNMYFLKHNLRATSGYVYFQDYMKIILKKQLERLNYGLNTPKDDNEAFLIESLLMWECIVESPRCLDWARQQFYSWSTQKDLTNNPIPNYLRSLVYNMAVKHGGRREFDFFWKLFLNSTDPGVRSQAINVLPSTRQESLISMLLEKSLSEIPKQYAVAVWSVEPPLGTRLAQDFLIHNFDRVYDKFSQMDAFMFPAVVSGAFGFITTTEELNKYAVAVWSVEPPLGTRLAQDFLIHNFDRVYDKFSQMDAFMFPAVVSGAFGFITTTEELNKLKKFAHEHKEKLLPMSQTLQKIVDSATMRIHWLQRHAAHINNWFQQYVTVNATILQESIDNTTQPLLTQNITFNIPANNADNATVLPTDRTESVASTSPRVLASLSLVPCSRLHTALRQNITMIQVSMDTANVGYSYHLPTAGWNYKIRNTLSQFSDLFSEFNKYIAPAYHHDRCERSVPMRIYSMHKGEFVMVFIAFFACFGLGVFIGLAGPSPTSMTSVAGSSVLANASEVFRGPYSLRSPALGTRSQQLWLFAEILTNNNDEEIFDKSFQISISIDGVLSDHSTTNLLPESDATNRTQHLKCKKQICEEVMVLHLGALEFTHYVLNIRFYGLQEFHKRYFIREIVFYFKTYNPAFTQMETWFRFIFLLTTFTVACWFAHSLRKYSTQDWAIEQKWLSILLPLLLLYNDPLFPLRLVSTGCFAPFIDTVFQSMFLICVLLSWLALYHGLRQNERRFLSFYLFKLIIVGLVWMPVMIITVWQKYYAFYDPTFNYALNTNYPVIKIVFFGAITLYFLYLLVLIIKAYSDLRNMPFFDIRLRCLSIIVGTVTTITTLLALQSWGPAALQDHWASQPKVTYDTSAPFMALYGLFNFKMYLLAYLFSPGIGSIHETAITKDNPAFSMINDSDEEVIYGSDEESRRPLNSHRRVSHEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSD7</accession>
    <name>A0A194QSD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSD7"/>
    <dbReference type="FunCoup" id="A0A194QSD7">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSD7"/>
    <dbReference type="KEGG" id="pmac:106719850"/>
    <dbReference type="InParanoid" id="A0A194QSD7"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF240">
        <property type="entry name" value="LD25378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="495" mass="54233" checksum="D5C11293C3BC116E" modified="2016-10-05" version="1">MAKVSASEGLQPKEIDVGDDVNDEKGSSERVRLKKELSLLNGVAIIVGVIVGSGIFVSPSLALKNAGSKGMALIIWVLSGFLSMIGALCYAELGTMIPKSGGDYAYIGEAFGPLPAFLYLWVALFILVPTGNAITALTFAQNILQPLWPACQPPTDAVSLIAAVVTCFLTAINCYNVKWVTRVQDTFTAAKILALLVTFFASLWYLFSGHTENLENMMEGTKTAPGDIAIAFYTGLFSYSGWNYLNFVTEELKEPYKNLPRAICISMPVVTVVYALTNVAYFAVLTNAEIHASEAVAVTFSEKILGVVSWIMPLFVALCTFGSLNGAIYASSRLFFVGARNGHLPLVISLIDVRRLTPVPSLIFMCLVTLVLLMYNNVESLMIYVTAVEAIFILCSVAGLLWMRYTRPELDRPIRVSLVFPMIFLVVCTFLVVFSCFNNPMEVGIGVAFIAIGVPFFYVFIVWKDKLTWMQSACNSFNLTCSKVFLCLPEDSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSE3</accession>
    <name>A0A194QSE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tripartite motif-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSE3"/>
    <dbReference type="STRING" id="76193.A0A194QSE3"/>
    <dbReference type="InParanoid" id="A0A194QSE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF285">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="330"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="776" mass="82421" checksum="4C9AAFF26A09F2C2" modified="2016-10-05" version="1">MASMSSTLVETVSINYEDFNESFLTCGTCLCTYDGGEHTPKLLPCSHTVCLHCLTRIAASQTRDAGSFRCPICRELITIPRGGVPALPPSFLVNQLLDLMARQRREVIPQCSSHPGRELLFCETCDCVFCRHCADGPHSDTPCDHTVVPFSIALKRMSEILLYRANECLSKLGSARDAVASELRRLEAAATAAEEAIDRHFTELRAALDKRHSELKSAAAAAATHKRKLLEEQLKLIDAEKTKVEAECSGLQQQVEVREVSSRAAALGARLGDAAALAEPRENAFLAVDFAHNDAQQRFVEALAELGRVRTSTTFPGLCTLQLESVCVCGLEVAVVLRTVDYHGEPRSTGGDPVSAAATLDDAPLPCAVTDLDTGLYRITMRPWSAGAISVRVLVFSRAVRDSPLRASVLGAAAPLLVWGTRGTGKDQLSQPVAVARCPKRREIYVLDAGNSRVKVLDDETFAFKTHIVNEGLSGRSCTGIAVTAEGVVAVNWRTRTLTEVSVDGCTVRTVRSERLVEPVAVAADVASRRLAVADNGARAVFIFDAHGNIEREIGSGELGLVGGLALSGDMVIIADVAVRIYDLQGNLRNTIAPVPKGRGGYGGVALERCEGGEGAGEGECVIVCTRAVRGRPALIGSGELGLVGGLALSGDMVIIADVAVRIYDLQGNLRNTIAPVPKGRGGYGGVALEVEGAGEGECVIVCTRAVRGRPALVALEAGGRVLAACELAERRPRRGAGLGLSRGLLLREKSGAASYSGEVPAHIVQYPHNFIPTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSH3</accession>
    <name>A0A194QSH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_12226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination. Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Polycomb group (PcG) protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of caly/calypso, Asx and sba (MBD5/6 homolog). The PR-DUB complex associates with nucleosomes to mediate deubiquitination of histone H2AK118ub1 substrates; the association requires the positively charged C-terminal tail of caly, probably due to direct binding of DNA. Interacts (via ULD domain) with Asx (via DEUBAD domain); the interaction produces a stable heterodimer with a composite binding site for ubiquitin. Homodimerizes (via coiled-coil hinge-region between the UCH and ULD domains) to mediate assembly of 2 copies of the caly-Asx heterodimer into a bisymmetric tetramer; dimerization enhances PR-DUB association with nucleosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="13"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSH3"/>
    <dbReference type="FunCoup" id="A0A194QSH3">
        <property type="interactions" value="1047"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSH3"/>
    <dbReference type="InParanoid" id="A0A194QSH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000002">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 12 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="15">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ08473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="503" mass="57306" checksum="7423DDB6F67974BB" modified="2016-10-05" version="1">MPVELNSLTEGWLELESDPGLFTLLLEDFGVKGVQVEEIYDLHKPLESPVYGFIFLFRWIEERRSRRKFVEQIESFVRDEETINNIFFAQQMVPNSCATHALLSILLNCPNLHLGETLSRLKHHTLGMNPENKGWAIGNTPELACAHNSHAIPQARKKADKNAGVSTGRFTGEAYHFVSFVPINGHLFELDGLKPYPTDHGPWASDEDWTDKFRRVMAERLGRDAGEQVHDIRFNLMAVVPDRRIALTQKLQSLEMNQKRVKEAISKISKHLRHMLSKNRELNEDTASQVSSDSLIDTIQITEEAILNAIESSQAQTFDIDYTHPITIEIGASDRPQQDNSLALVDPVEQGDTVKFVTLNRECQILDDIYPTSTSALVRSNDMAVLVYCEGAAAEQPFRLKKLLLTQPELALLMANIVAEVQACQQALNDENDKRDMYKVDDCRRTHNYDEFICTFLSMLAERGALAELVAAQLERGRSTRTRRRRPRPRPRARPRPRPRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUL0</accession>
    <name>A0A194QUL0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUL0"/>
    <dbReference type="STRING" id="76193.A0A194QUL0"/>
    <dbReference type="InParanoid" id="A0A194QUL0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="142"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="472" mass="51982" checksum="C9124C739329B770" modified="2016-10-05" version="1">MPIKILLARQIFDSTGIPTVEVDMVTELGLFRVGVPNTDVKKIAEAVQLRDNNPAEYLGMGVSNAVKNINTIIAPELIKQNYEVTMQKEIDQFMLALDGTETRSRLGANAIMCVSMVVAKAGAAKKGMPLYRHISDMAEVTSIIMPVPHFTILTGGVLSSNELPFQEYSIMPTGASSFSEALRLGTEIYQYVKKTIISKFKMEASYVSDNGGFSIPLRSNRDALIFLTDAIKQCGYAGKVEIALNASATDLFKDGSYDLEFKNPNTNPQDYMSSDKLAELYLESMKEFPICSFEDAFDYDDWAAWSTLTSRTQAQLFGNDLTQTNLRRVGLAVEKRAGNTLGIRINQSASLTELIDVFKLIKTSGFGAVVCDRWGDTDDLFLADLVVGLSAGQVKCGAPARSERMGKYNQILRIEEELGALAKYAGSNFQAHSLSWSRRGEKPTAGTLHAKIWVPEDPKMFCASNNIVDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUR5</accession>
    <name>A0A194QUR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUR5"/>
    <dbReference type="InParanoid" id="A0A194QUR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="299" mass="33791" checksum="55705F9E7E490FC9" modified="2016-10-05" version="1">MEGLINKSSSKKSSNILDYGKKQTNKVSVKNTHMNQTTKKSNTENFDRKVGSTVTAINPKQNKNNFPHSTSTNNDKKYSPNIFGEKAGSSKNHGLSTFMPQPTPVADNNYVSSSYKDAKNKKSSMRFGIIWLPTKRRNKLKDNLNHSDGRDRSKERTPSMYKFMSDRSLDQIETTKERDLFASGTLKMTSPVYFGKKTSEQSLDQNHLYYDKYDDQDEREGNEAGGSNTSVNGAKEDTSNQETNADKKQSKGEDVVDKVNVLHRQSISKEQTADSTGEKEECIVVWLHYMLQCSDCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVP8</accession>
    <name>A0A194QVP8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin-likey domain-containing family G member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194QVP8"/>
    <dbReference type="InParanoid" id="A0A194QVP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="307" mass="36555" checksum="D8A1C5EA1C05BFAF" modified="2016-10-05" version="1">MQRYYEKCNLSPSEESQQAVIRELVNTEADYIRHLKSLVEVFMAAAHALQESSFMLEVDTQRLFSNIPDLYNASLEFWNATFYPMILDSVETGGPLKPELMYEGFHNIEDYFQSYETYLMDQSRAVEYLRSLAGNTEFMSYLSWCHKQKEINRLQLADMLAKPMQRITKYSLIINRIHHYTEKDTARELINSMETTIKSFVQHINRCIRQREEKDKIMTMSNLIDAYELEFKDEEMERCYRLYYQLDLQAPMIHAMSDIIRCMVFNGDLRFKDNTNKEARKVTTTEPCVLLSVQEEHWFIFTFRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVW0</accession>
    <name>A0A194QVW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcription factor SOX-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVW0"/>
    <dbReference type="FunCoup" id="A0A194QVW0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVW0"/>
    <dbReference type="InParanoid" id="A0A194QVW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF317">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="423" mass="47279" checksum="97B7BC68C38D0CB8" modified="2016-10-05" version="1">MHEVRFPMTLGHANCKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQNKTRPNQPAPPASAPPATSAALGSPYATGTDSPDTRFSHNPGAGFSPYRTSPLASDYQQNQYNGHVQTPESSPARSPEPQGRRSASTEAPLPTPDASPVENEKENFQYEERRRAINASSISDSYSYKFRTPGSYSPAPVAAMGMANGMYVMCTQRTLAEQSPLVTGTFFPPVATSQDQQTLGTSAPRVSSAPSGSMNAEYNIQYHPYEQYEQIYKTEDSYVSHYPEQPKTEYDTGSSYFSEEPPSNQPQENEQGFMPRSEIRTGSPESDVDAREFDKYLDYGTEGAMDQHQQYRYEQQQGYRPYCGEAAPGAEYCGERMYASPYPTVISGAPPPGQYAPPAPPGAEVRPEDEFSVILAGVRQTCYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWP3</accession>
    <name>A0A194QWP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWP3"/>
    <dbReference type="KEGG" id="pmac:106716892"/>
    <dbReference type="InParanoid" id="A0A194QWP3"/>
    <dbReference type="OMA" id="GVPNFPF"/>
    <dbReference type="OrthoDB" id="7465547at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264701" evidence="2">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="251" mass="25472" checksum="F931C2B0B00E3263" modified="2016-10-05" version="1">MQFLLLCVCLSVAVGTTLSTPIPADGFVFPDAVRNQRKLEPITPPVLPVLEHLERDPSTLLPGEGNRRMSETPKPRFGFGGGFNVAPTGNGGLSASVSSSASGAGLSHSASQSFSFGFNEGFSASHSASQASSFNGFGSFSGSQASSQAASFSGAGASLSGSAAAAAAQAGSFGSQSTSSAFGFNSINDGFPRPQASFGEGLLDIRHRGVPNFPFPNLLARNKGSGAAAFRTLNGPKSRNGDDFLAVLVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWS1</accession>
    <name>A0A194QWS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWS1"/>
    <dbReference type="STRING" id="76193.A0A194QWS1"/>
    <dbReference type="InParanoid" id="A0A194QWS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="545" mass="57629" checksum="E5507B43B60B1264" modified="2016-10-05" version="1">MISGLSLMQCALLASHLRRKRYLMIYNLIELNNESYSTKAAPTDSANGECEKIIVVISLLANVLAYHDPDLNYHLSQVQKGQGCGDSGYSYPVPTTQLTTGVASNQYGGVAYQQQAIQATAYQAPLVTQANYIQTANQNEFHGYATSAGLSSAASSGRTVTPSATYAQAPIIAKVTAAPLIARYSLSPPRTTYVSNNLLTQQSISLGSAKASLNSYSVQSGGPVVSQVFAAPTVGYKTSSAIQVQQTPQIAYATAAPAVINQYQQAGPIYRAPAIATSQYIAPTVEEYHARSGGQYNSQSNAASIGYSTSKVSQYAPSVVTQYSAPAVTQYSAPAVAQYSAPAVAQYSAPAVAQYSAPAVAQYSAPALAQYSAPAVAQYSAPAVAQYSAPAVAQYSAPAVAQYSVPAVSVQHAAPLVRYSAPAVSVQRSPSVVQYSAPAAAVQHSATVSQYSTQAALRGHASLGVKNVHTEFLENYDAHPRYAFEYGVNDPHTGDIKQQKEERDGDVVRGQYSLVEPDGSVRTVDYVADWETGFHANVHNSKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY73</accession>
    <name>A0A194QY73_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_12279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY73"/>
    <dbReference type="FunCoup" id="A0A194QY73">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QY73"/>
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    <sequence length="433" mass="47131" checksum="D74CA9B458EE2BE6" modified="2016-10-05" version="1">MPIKSIKARQIFDSRGNPTVEVDLVTELGLFRAAVPSGASTGVHEALELRDNVKSEYHGKGVLTAIKNINDIIAPELLKQTFEVTQQKEIDQFMITLDGTENKSKLGANAILGVSLAVAKAGAAKKGVPLYKHLADLAGNSNIVLPVPAFNVINGGSHAGNKLAMQEFMILPTGASSFSEAMRMGSEIYHHLKKIIKEKFGLDSTAVGDEGGFAPNIQNNKDALFLIQDAIKQAGYTGKIEIGMDVAASEFFKNGTYDLDFKNPKSNPADYLSSEKLAEVYLDFIKEFPMVSIEDPFDQDDWSAWTNLTSRTPIQIVGDDLTVTNPKRIATAVEKKACNCLLLKVNQIGSVTESINAHLLAKQNGWGTMVSHRSGETEDTFIADLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGDKAKYAGKNFRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ97</accession>
    <name>A0A194QZ97_PAPMA</name>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">Ya'a_city_454_Pm</strain>
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            <name>Ca(2+)</name>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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            <begin position="1"/>
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    </evidence>
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    <sequence length="649" mass="72400" checksum="664A72F3E9527511" modified="2016-10-05" version="1">MRVFLLCLLLEIVWSRESDWRPIVPEPSQAYTSYANLADRSIDAGCVLKIMRVFLLCLLLEIVWSRESDWRPIVPEPSQAYTSYANLADRSIDAGPQLKILNRRPIQASHTTNKLTSFYNVASAPSTDTCSVYKVSMNQELLYQYLEYDNLLPDLKEFTLCMWTKFHNHSQDHPLFSYAEKGSQNKNSQFKLRTTELKGNVYAAIVNLNILVLDKSAVGDNPKEISSWISNTQEASYYSMAVHGQTFFRLNYPLKLNTWYHACQSWNGKTGEWQVWVNAERVGRGFHNRLVGHVIKGGGVAITGQEQSLLYNKDGLDPVIHQSGLMGEITMLQLYHVALTAGKAHKDHKHHHVHHFKHDGTPLDQPTEAATEPPPPQPTHLGNGNYLIGGQLQRAPNLNLAGTQQQMVPVQLPNGLQIHQQYVNGQLGNRVVSEQLLSEVQSPNGIVGAASQIPLVGLSITPLSQSPSYSPRQVQQSSAPTKTSTVLFSSSLLNPANVQYIDGPSSHKLFRRDSMKRDKRDNPEKELIEENASSKKDKRGLVSLSDGSIVDEALLTPSIVDDSEDAVFQRSLLQGLAGVVGNVPIQNLQKQNSDEREPAEAEVRAVMQVCSGCAQEPFKKALVLSWRSTPKKLYSGAHYYKGLPICRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZD9</accession>
    <name>A0A194QZD9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZD9"/>
    <dbReference type="InParanoid" id="A0A194QZD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="10905" checksum="A01474A99E380340" modified="2016-10-05" version="1">MKGSFILQCGISHRLMTLLMRRFLVDSATTSTEGTSSDSGTVADSGSETGSVSQTSGSGIAPSGSSDVFAHHAHGTVAAAVGDGTSASGRQRTLQTDGAQERKLTTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0L7</accession>
    <name>A0A194R0L7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase N2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0L7"/>
    <dbReference type="FunCoup" id="A0A194R0L7">
        <property type="interactions" value="1954"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0L7"/>
    <dbReference type="InParanoid" id="A0A194R0L7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="344" mass="39858" checksum="7CFA6829D07B42CB" modified="2016-10-05" version="1">MLMDLFYETVPIKEKLRVHFNSFMLNIHSRIHELKIQSGKGASSFRDEASKPFDPIPPVAADITQESWLICFDEFQVTDIGDAMILKRLFTQLFDNGCVIIATSNRKPDDLYKNGLQRSNFLPFIPILKEHCTVIQLDSGIDYRLRGSGNKYSKFFINSELNEDNNAVNTLFKYLVSMETDTVRPRIINIMGRNVKFSKSCGRVLDSTFEELCDRPLGASDYLVISKTFHTVFIRNLPQLSIMKHRSQLRRFITLIDTLYDNRVRVVIAADCEPKDLFRMEEKDEFGDADRALMDDLKITKESDDAKAAIFTGEEEMFACDRCLSRIMEMQTEEYWDKWGKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0S4</accession>
    <name>A0A194R0S4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein still life, isoforms C/SIF type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0S4"/>
    <dbReference type="STRING" id="76193.A0A194R0S4"/>
    <dbReference type="InParanoid" id="A0A194R0S4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="349" mass="39054" checksum="0280FE8E471D1F03" modified="2016-10-05" version="1">MVETHRAPAPRCARAPEPRGKPAPASAPPSLAGSGTLLHLRRRRHKTVHFGENLLMQVCADRAHLATLGARIPDISFCHKAHTGLRKGDARFCCVAHHCCLAAGALATLASTASTGPIARPKPRRERSGDSHSSGGETTERGDSVSGAAASDNKRKTRHHHHHHHHHHHKVHNCPYHDIVPPPEEEPEEKPIVSKKTVSPYLYIPSKLEPNVQQLFSFIESVLSAWAAEEGLTSTGEYSEPDERIVRRRKLNKYKKRTDVLNIRRIVYEVSILHGAKLLGNVRFRHYHWKGTSQTCNEAFLRKMNQETLVFIRKHFDALSVACRVSKMRSSQVYLYVAGLINGFQVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R184</accession>
    <name>A0A194R184_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R184"/>
    <dbReference type="FunCoup" id="A0A194R184">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R184"/>
    <dbReference type="KEGG" id="pmac:106714743"/>
    <dbReference type="InParanoid" id="A0A194R184"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="935" mass="101056" checksum="287DF0E08663C16A" modified="2016-10-05" version="1">MEYTAQNLEYAVNVFYNGEQTEKTNAHTWLTTAQRAPEAWNFVWELLQPHKGTEIQFYAATTLHTKILRCWNEVPPESYEELKEKILQAVTSYSQGPKIVTNRLCISLAAVILQLGATDLASTLRPLSNVENTSLLLEVLTVIPEEYNSMTMGTALRTKNQNALLHACPAVLDDMLRYLQSAYNDYSKGPPCDETVKTWLNVAACAGSWLTMACGDCMAYTTTSVPDFAPLCRALLTVVHVLYSCYEAVSDIALEACESALSAVRAAGGGAGSLRRPVAAEQVLADLLQLAERVLARDNVPNSINEELLSAVITCLVSVADCHSRQVVRGVVAEERAPRQALELLLAAQSAPGHYPLHETRSHFVFSFWYTLQDEISNTLDSKRKMHPVWLDVFSRLLLSLVAKAEVPADSALSQDDRELLRCYRQDISDTITYCFCVLDDSIWKVLEEAYPVGGSEERQEAVLFAFLAVGEIRLTKQAVTPPIGTLLRHAVRAANTANNKNLLETALDCLGGYSTWMSNSSSAEEVELARQSILAAGAALQRSPARAAHALRKLCTECDALAASMAEDIVNATQNGMVRCDSFVRRQLAGAAGAALAAAPLDVAAPLLQKLAQSLLVDLRAQAAEGVRARTAAECGAALLTALVAAPALAGELFQALLPALAHFAHHADLLEAMYKVLDQALSSLLDASLPHMPQVAELAVAGFHTQPCAPGLVVLNLIMLISYDTWSEAGRVLRACVSASAARAAADVRADPELTSQLFLTLATLTKKMPDCLHWIEDLLSQLVELACRCVTVWDAATARGACTWLIALAARQPAPLLPHAPALTAAAICCIGGASPRAQVSALSELLLALNRAELGAGAGLRAWLHAALDVDGFPTHHATRSHKQKFITAVLKERNNRRIVFEAAQEFSLVCRGLVGTEYARQTIASKQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1D9</accession>
    <name>A0A194R1D9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1D9"/>
    <dbReference type="InParanoid" id="A0A194R1D9"/>
    <dbReference type="OMA" id="INELEGW"/>
    <dbReference type="OrthoDB" id="8186615at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="25839" checksum="3280D39409A6F430" modified="2016-10-05" version="1">MGEPSSDSNTYGMENWTKEEKYNLFQALKVCDFHDYEKLSTFITTKSIDDIRGAIAHYKNKISKHPVLYKKVKKSIKKTGGNLIPLTDWAKFLTESLNLKDLRTETATALRLIADFEEFPAPICTNNIDFSKIYHTLANALEGKALTKDKMIISMMDKCLIDSALTSKAFIRSSSFKNVLKTLNMSDNELNSFPHYTDNQELANIRHLASLRSYNPLNLSEDVLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1G1</accession>
    <name>A0A194R1G1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1G1"/>
    <dbReference type="InParanoid" id="A0A194R1G1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264831" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="20354" checksum="1996731E18C3F57B" modified="2016-10-05" version="1">MAGMYLKFAFCFVLFVSLECRVIKIIDDEDSNNDIVVKIILKHNKKEHSKVKKDKEEKLKEDLDEADKLKAEAKLEEIIEEMKNEMNKKSHKNKEDSHEEVTNASGNDNFELSKNELPDNLDESEDEPRDSISDNLIDKEPQLTEYIPKFNSRSLIQVGVCPLGFIRRGPICSPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2Q7</accession>
    <name>A0A194R2Q7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2Q7"/>
    <dbReference type="FunCoup" id="A0A194R2Q7">
        <property type="interactions" value="1306"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2Q7"/>
    <dbReference type="KEGG" id="pmac:106714057"/>
    <dbReference type="InParanoid" id="A0A194R2Q7"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="9">
        <location>
            <begin position="210"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="649"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="888" mass="100866" checksum="6859D89D2919E6DB" modified="2016-10-05" version="1">MENKSLSSKTTPTWQNCVHCPSLLFSSALEFERHIQDKHSIKEGSIILCQYGQNGICSALQFGDLRKAGFKYHVREYHLYAKGGSEDWTFYSSSQNLPAVLNDPNKGKQSNFFTKTWGDSFVEKVDIHPSPYLPDIGLSHFESYCKKISRRYRRHCQLKEAPPVKSKLKVAVAEENICEVPNIFYSQTLLLNDPQIFSQVFPGLSNSSDSSSAIRSLQETLSTYLDVIEMKISKQVAQKSDAFFHAMLSHDTIMEQMAKAVKTVQITRCNITTVKQNLTQCPLQLISLTRINNNLNNVCELLKLIGTVQQTQPMIQLLLSTSDYVAALDLISSTQKVLLTRLSGIQAFRHLSPQLTEMRRLIHKMLSNEFLRFIVTDLNRPLIDLTDLPDKDKIVSIVSGILRLKEFDFLDIFKAEAMTSIQATIKQCVIEIISERDGSSEIVLRGSQSDNTWLMCNEGIVFLQKVTPNLVIIFKRILSLSSLILDISQMDDVTGNESEEMWTQDEIASISDKIKKMIGSLSDYCNERCANLIVTKTDKDYIFSDLTQLAKLTELIDAFSNECEKITGHYSNTMKLALRSFAMKYIQSLHTERRSQLTATLNAERWKMADVPYELQSVIHKICEFGKIPHTLHYESGRPDGKYLVINKENYAVVATVQLLIKILLEYCDATKQSPDIVQYLVHCMLELIRLFNSRCCLLVLGAGAIQSAGLKTISTSNLALVSRSLQVVLWLLPLILDLLEKLHSKELTLNGFASIENDLINHKQEIENKICIIVSTMLSSQLSSWDAKPPVPSQTFRNISKHLVKLHEALIDILPIEQIRSIYMKVHDNFKDKLREQLVKMNIVANGSPQHGVVTSELTFYLQTLKTLRIINENDTEDNILYDIWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2X0</accession>
    <name>A0A194R2X0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-tocopherol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2X0"/>
    <dbReference type="InParanoid" id="A0A194R2X0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="134"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="40695" checksum="B3E2098E5D486978" modified="2016-10-05" version="1">MAGAVAIYQKYDVICKCSRKNRTCGLYSGRASERRARMKSITGHPLIIVTEEDVEKSRSLCGVEQPERIKESLDSIDEWCKKQDHLVEAYNNLDRNMLERLFLLARGSVEATKTRLDKILTSRGMMPELVLNRTVEEFDELLQGLIYIPLPRLYSVDQSRIMVTQFFPGKLDNFNLLSYLRYCFMIGEYRLYYDYCLSERYIVDLANVNLSLLSKINPVILKKGEILCSEGLGTKIKGIHILNAPPYVDKFLFVLKQALREKVASRIHVHSSYEDLRQHLPKEILPMDYGGDEQYVEKLASQWREELTTKKARQIIKDMDKLVSDETKRTSSKFNEEYMGMPGSFRKLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3M7</accession>
    <name>A0A194R3M7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3M7"/>
    <dbReference type="InParanoid" id="A0A194R3M7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9990" checksum="20E039D94D469834" modified="2016-10-05" version="1">MATKSKTKCSSCGRFKGSDNPRNVKQIEKFLKRKSKEAKLRKKDRLTGSHSYIKYLRKQGTPRSKTECCAGKGHRGRLKKKKCCEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6B7</accession>
    <name>A0A194R6B7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6B7"/>
    <dbReference type="STRING" id="76193.A0A194R6B7"/>
    <dbReference type="InParanoid" id="A0A194R6B7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VHS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8710" checksum="6CA7DBAEF62D673D" modified="2016-10-05" version="1">MFRVNNFDKLLDKATSNLRLEPDWPTILQICDLIRQNDCSPKYAVAAVKKKLYSQNPHQAMFALLTLESIVKNCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6S3</accession>
    <name>A0A194R6S3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6S3"/>
    <dbReference type="InParanoid" id="A0A194R6S3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="429" mass="50075" checksum="4825840326E85D02" modified="2016-10-05" version="1">MHHRPELNLRLELSLNLDNAELDNWLGKFDEELDYRFDHDIPLQRSISLDGGIEIFNYLNTLGSDWSGASEWSLNSNDSDRMLEQYRSFEDVPASQYKMISRRASLAMGNEVNNMALHALRSYKGVEMEKGRLSPQVKKLQKTFSFKSFFDEVKESEKSFNEGEIEDDEMLEMRAPLIRSVSYESRTAKTDDRDEGSGNMLRQRRMGTIHNVWYEETQKSRTLRKKVLMKRCTSHIQFKSSERLGKSIDDIRCGSVENVANLKPVPFIRFKDRYKDIDRISTFNIQKHKSDINFITIPTIVVTDTDSLVKDDYKIDTLTDMHHDNSIESVANQVNIDTSDAVEEKESICDCRICREDDEDYSKSFLSRKLNKLFIKIVSLIEFGKKLTYWDDNNNISEGEMYSCIMHVLKLMFGLWLRHFDHNPQVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R816</accession>
    <name>A0A194R816_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethanolaminephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R816"/>
    <dbReference type="STRING" id="76193.A0A194R816"/>
    <dbReference type="InParanoid" id="A0A194R816"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="10871" checksum="F2C49580E4AD58D3" modified="2016-10-05" version="1">MTTGPRLFYILTGTIFSNINCRLIVSQMSDTRCEVWNGLLVPYACAVTLALCGTLSPMSELLLLAGLCAAVTAAHLYYATRLVSNQHNVCNIIALLLIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R870</accession>
    <name>A0A194R870_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium channel protein Nach</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R870"/>
    <dbReference type="InParanoid" id="A0A194R870"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF247">
        <property type="entry name" value="PICKPOCKET 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="516" mass="60128" checksum="320DBEFCC39753ED" modified="2016-10-05" version="1">MSQIEPKIDTTHDVSSANSDIESLRSLEYMGNYYLKDYEYLSPKVLERGRGAGNIVASLERNKAGNCKLFARLWLREVMKGLKQFLYEGSLHGVKYIFEPTFSFKERMIWVVILVISIAICAVNIFQLFSKWHSTPFVNVIDSLPTPIWAVPFPMVVVCPQLHLQRSFVNVSEIDKQSLNHFFASLVCPQMSRTKQAPQKRMTPKDNVQMQKFIVEGSPKCTDIIKSCYWRPTQEFEWLEKECCEKMFKPIFTDYGLCFAFNSLPLNAMNNDTQYWHKTFDKDVTQQPLNWSLDGGYPKVFPPDPTMIPLRVMASGEIHGLGVELYLNSSEHQYECDGNNLGYNVLISSPTDHVYVSTVLRLPMNKMTTIEVSPTTYKTDNALRALAPYIRQCFFQDENKLNYYEFYTDSNCKHDLWIREVKKKCHCVLYNWPRLYIWESICSTKSDFRCIEEVRAKVEEKLTYAYYEDSQEDRKAQTEFASCYPACNDILYSSQVFYSDLISVPRISKSDFRFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA85</accession>
    <name>A0A194RA85_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_06927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA85"/>
    <dbReference type="FunCoup" id="A0A194RA85">
        <property type="interactions" value="1449"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA85"/>
    <dbReference type="KEGG" id="pmac:106711170"/>
    <dbReference type="InParanoid" id="A0A194RA85"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000166">
        <property type="entry name" value="Trna selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF3">
        <property type="entry name" value="TRNA SELENOCYSTEINE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="33497" checksum="26DA0CBEEF1FAC83" modified="2016-10-05" version="1">MAMQCQLWMGSLEPNMTESFIMAAFHRMGQRPLAVKVMRNKFTGEPAGYAFVHFQTDEEAIDAMHKLNGKPIPGTFPVVRFRLNTASREARSNLQQEREFSVWVGDLSPDVDDYSLYRVFASKYSSIKTAKVILDGTGYTKGYGFVRFGNEEEQRNALYAMNGYTGLGTKPLKICTAVPKPKGATTTQNSTASVSSNTAYNSGSQDYNQYYDPSTYWQNYSAWSGYYGQGDQSAAAVTTPVAEPVQAAVVKAQNDELALVEHKKTIDIDQMNQEFLDPELSLWDALESSQWFPNEVIEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBB3</accession>
    <name>A0A194RBB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coagulation factor X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBB3"/>
    <dbReference type="STRING" id="76193.A0A194RBB3"/>
    <dbReference type="InParanoid" id="A0A194RBB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="345" mass="37235" checksum="E0ECE81C7B8A73E0" modified="2016-10-05" version="1">MTPYLLSITPFAFGDSDPKWALASDNKVSTFPDPTPSRLSSGPAAPEDLYPPHPSSNTCDGQLGADHSVVSSCGVARGARVVGGGAVSPGELPWLAALKRDGKVICGATVVARDHLITATHCIFDNTCSHAQESPDRRMGCHRVTREMTADGVEASRLSVLVGEYDVNNSQQDGIPVAHVTQHPDFNRFTYDNDIAVLRLSEPIPEHLYRSACLPDFEDDNRLEGVEAIVSGWGSTIEKGPPSSIPMKAEVNIWAQEECSGAGYGRRKVTPRMLCANAPERDSCTGDSGGPLLLTRPHYTIVGIVSWGRGCARQGYPGVYARVAKFLPWLKVALRHACMCHPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBN2</accession>
    <name>A0A194RBN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alba-like protein C9orf23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBN2"/>
    <dbReference type="FunCoup" id="A0A194RBN2">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBN2"/>
    <dbReference type="KEGG" id="pmac:106710779"/>
    <dbReference type="InParanoid" id="A0A194RBN2"/>
    <dbReference type="OMA" id="VTCAEIM"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="20027" checksum="AD6F2E71A07EB16B" modified="2016-10-05" version="1">MENYFKGKNVEEELERNKIPIKDLPTDFLWMQVKGGSKMSNLLAHASGILEDKAASSVVWTGTGVAIPKAISCAEILKRQFSIEHQVTKLTFKKVEEYWEPKIDGLEKIIVKREIPVIHIFLSIDEIQDKNQIGYQSLKGKKFWQKGQTSTISKNQQPYKTKKPFKHKKNQVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCC4</accession>
    <name>A0A194RCC4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein hairy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCC4"/>
    <dbReference type="FunCoup" id="A0A194RCC4">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCC4"/>
    <dbReference type="InParanoid" id="A0A194RCC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="23484" checksum="2829F6BB7324D5B9" modified="2016-10-05" version="1">MEKRRRARINNCLNELKSLILDAMKKDPARHSKLEKADILEMTVKHLEGLRSEGVASPDRFRAGYRHCLSEVAKYPGLEAGLKRRLVRHLEGCVTPGARPAAAPTPPSDNEDHVTPQHSTIFISAGPGSGVRLVPTRLSNGDIALVLPAGVTTSTLGALPTLVPLSPHEGTSSTSSEARCFSPASSGWGTPPPNDESVPLALITRRQSPEEKPWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCD3</accession>
    <name>A0A194RCD3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-dependent DNA helicase HFM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCD3"/>
    <dbReference type="InParanoid" id="A0A194RCD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19862">
        <property type="entry name" value="DSRM_PRKRA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19864">
        <property type="entry name" value="DSRM_PRKRA-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="1516"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="1618"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="1813"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1885" mass="214391" checksum="309A49B867694B9A" modified="2016-10-05" version="1">MYLGLPKSAPTDLISKKIEELCMKAVNGLESSGLMTKDEVCCIQSTEAGRLLSIYYLDLETMKRIMKDEVCCIQSTEAGRLLSIYYLDLETMKRIMKIKGDESLEQLLWVVCESHELSDMHLRVDERRCLNALNRNNTAATIRFPMKGKINTRQMKLNCIIQAVLGCLPIHEPSLNQEAITIMRIAVRICKCLVSYVTRPNALRTSSQNYQAILNAIVLAKCMESQLWENSKYVSKQLKGIGPTYSTLLASAGKINFMLLEESHPRDLERIMNKGPPAGNVLRKQISLLPKYQLTITPIDENSIKIQLKLLNQIYLAESLDQLTAGTNHKSYLIIGDSENYLLILASFKDKDLITFHNGEITYQTVRRHQFEHKIMAHCISSNFAGIDVHCEYLFQELDFGSKDIIPISPIEKTDRKNIKQTAITDTFKIRKRKNHDPVDTNVVEKKKCDFAIIEQIKSFTQSHNKLRNVIESKNNKDIDNFHDLQQNCFDVDLDNDDQVFTNLNEINIEKDDEQINEILNVIDNEILQQDRPNFNIPQNQVPVVSDTGGNKTYDSEVRTTKTRIRCFNETMEKEKNNFNVIDRVQNKAFFTNFSGSNKEEDDEQINEILNKIDKEILQQDKPKYDITEKQVPVISNPYSIMNVGKKTNNSEVKTTKTKTGYFNKTIQKEKNNFNVIDEIQKKANNMTETENRDTDEQSTFVNTVKNHIDEYLEKAKQSSKVAEKQILQLVEISPNKTITKSFCKKKTDAKQNIVTSDKGLSETNDQKNVYLTDKNIDDTLKDNENENTVSIYENKENIEEFKLPQIQKEDLDYAIASEISNVNKTNSVISLRKNKPSLNHYVVNELESRNFKEGYSNYTNNRSIWNTSDIGKTNQIPNHENERNISKDFFALEELQNEHENDRISNAVTNIYSKDHEVLDHENKPSNNNSIDYDHLKNSEKTKTISQLENVKHNTTKDCILQKLKEIDDYKDVRNNNKDVHTNCVNPDQFNNNESMEIDYSNDYDESNKALVPILSSNAANNVYENCKLSPNSTLEQAAEKMEEKEMLPDSKKYGSSSPSVIKNNISFQPYFNKVLDNTVSFGCEYMKKFSFTKTQVNVCTKSNTEANYCIISKVQIDLDIIKNQSTIEKGNFKPIEEKLPNVLEDNKLNGDQNNLENSKINIEETRCKNDIVKREQTNNINNNQDGLSTIQSKFKESPQTSIELKEQCEKTYMEQYYSVPKTCHTVKDIINKYQKLASRIKDLDKHYKPKTQNTNIQPPPELDHSKLMAKIFESIKDSTETNKHELEVNKLIDEPDIEYTRNKNFNDLESPDLGSPDLESTDLESPIIDDESPSFEKTDLLNNDLDISQSMLNPKSLLESLAQNDITLPPLQFRDEAKRNSPVFDIDLNDFNLTNVDKINLDDAFEKDDNTSSTASEIETWTMSKDDETWSNISKPTTAEMDGGVVHPQSGGMHPGVPGVLHGMPMHGAGPDGEHVPHGPRRRFQNRPKQPNNLERLPLDEAAKREMEALPMKTPVSVLQELLARRGTVPKYELVQIEGMIHEPTFRYRVTVADLVAMGTGRSKKEAKHSAAKALLDRLTGAAPAEPPTNGNVPEPGAVVSLFEDKLMGNPVGWLYTLLTAMGTGRSKKEAKHSAAKALLDRLTGAAPAEPPTNGNVPEPGAVVSLFEDKLMGNPVGWLQELCMSRFWPPPSYHAENDDNVNRRLPHERQFTIVCTLLKRREVGTGKSKKLAKRQAAYKMWQALKDNPPESFQNEEEGVASRYADLKDSKISTLTTSHSHKVSQFHKHLKQSIGPNLAKLQVTPLNNKDFNFVQFLQEIASEQAFEVTYVDIEEKSMTGRSQCLVQLSTLPVAVCYGSGLTSKDAQSSAAQNALEYLKIMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDK3</accession>
    <name>A0A194RDK3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spectrin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDK3"/>
    <dbReference type="STRING" id="76193.A0A194RDK3"/>
    <dbReference type="InParanoid" id="A0A194RDK3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand Ca insensitive" evidence="2">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="8512" checksum="983E79C7C251F865" modified="2016-10-05" version="1">MFKFKNKTNFIARNKTVTESKTKLASINFKNLTKEMADYCVARMKPYVEPKTERPIPNALDYIDFTRTLFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDN7</accession>
    <name>A0A194RDN7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDN7"/>
    <dbReference type="FunCoup" id="A0A194RDN7">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDN7"/>
    <dbReference type="InParanoid" id="A0A194RDN7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14535">
        <property type="entry name" value="PTP-MTM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000038">
        <property type="entry name" value="Myotubularin 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="12">
        <location>
            <begin position="230"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="442"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="674" mass="76904" checksum="A638588CEAACC839" modified="2016-10-05" version="1">MDKHNSSELLNSDFSLSKNASSDSLDSDSKSSSLNSKHGQDSSQLLGDIQLLDGEKVMGVARDVTYLCPYSGPSRGVLKVTNYQLHFRPTEATSLQTTLSVPLGVVSRIEKVGGASSKGENSYGIEVFCKDMRNLRFAHKQENHSRRGIFEKLQQLAFPLSHRLPLFAFSYSESFPEDGWHDMRNLRFAHKQENHSRRGIFEKLQQLAFPLSHRLPLFAFSYSESFPEDGWHVFEPIAELRRMGVNNDMWRITRINDKYEICDSYPSIWAVPAAANDDLLRSVAAFRSRGRIPVLAWIHPSSQATITRCSQPLVGVSGKRSREDERYIQLIMDANAQAHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKELCFPQIDQTRWFSGIEASCWLKHIKCILAGAVRIVDKVENHKTSVLVHCSDGWDRTAQLTALAMLMLDPYYRTLRGFQVLIEKEWLAFGHKFQLRIGHGDERHSDADRSPVFVQWVDCVWQLQQQFPTAFEFTERLLITIVDHLYSCRFGTFLFNTERERVKEEVKSKTVSLWSYINSRQDLYLNPLYWGPSSGVGAQAQYSRPQIVLVPVASLRIIKLWKALYCRWNPTMRQQDPIYQRTRELVALRAQLEAAAAAAAGDHAARHRLALTPPRVASPHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF26</accession>
    <name>A0A194RF26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_13602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF26"/>
    <dbReference type="KEGG" id="pmac:106711500"/>
    <dbReference type="InParanoid" id="A0A194RF26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF92">
        <property type="entry name" value="ACYL-COA DESATURASE 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="76"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="45245" checksum="875BA15F81650FFF" modified="2016-10-05" version="1">MTAEDLSTGHTNIGDDTTLELKIKNCYTPARVIGTDYSFKHKIVWKNAIGFLILHLLGLWGLFVFLTGGVGIKTALWTAFVLFVSSEGITIGAHRLFSHKSFTATPLLRGILLILQTVAGQNSMYIWCRDHRLHHRYSDTDGDPHNAKRGFFFSHVGWLMSKKHPYVIELGKRIDMSDLEADWMVMFQKKYYYPLYVLFALFIPVWVPIQYFGETFKNSFLVCYFFRYLFQVNGTWLVNSAAHLYGTRPYDKNLQPVESWFVSLICFGEGWHNYHHTFPWDYKAAELSMHLNISATIIRWLEKIGLAYNLKTASPEMVAKRIIRTGDGTHYALGNDDAKARVTAIGPLHPINPSYTTKYEAPRTNLNDQGLPLFHETDVINVNTKNINRNFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFH2</accession>
    <name>A0A194RFH2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFH2"/>
    <dbReference type="STRING" id="76193.A0A194RFH2"/>
    <dbReference type="InParanoid" id="A0A194RFH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="19709" checksum="D6B23E1FB3AECA73" modified="2016-10-05" version="1">MESSNESLSVMSSALGSSSGVLLTPGRTRNIAQDMEALRLSRQDNPYLQQVMASRESLIDSHAEDCGSDDTILMSQEFGSTALDFVEEDPLTLKEVHEHMIRSPPPTSCWPHDINFALITHTTRSRHCHSLPLTLSGRQPAGGGQRARSRALRTHLLPCDFFVLCRRPRASSPAGRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH21</accession>
    <name>A0A194RH21_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_13738</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH21"/>
    <dbReference type="FunCoup" id="A0A194RH21">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH21"/>
    <dbReference type="KEGG" id="pmac:106708678"/>
    <dbReference type="InParanoid" id="A0A194RH21"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="112"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ16882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="51719" checksum="554CB781C1079BB3" modified="2016-10-05" version="1">MASQWGQKADELEISNKIGGLDLVKKNENQKSDTDDAPDAANPAEASLLMKIIRQGLVESKLDIEVQRKDPNSPLYSVKTFEALHLKPNLLKGVYAMGFNAPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVDPTKNYPQVLCLSPTYELAIQTGEVAAKMAKFCPEIKLKYAVRGEEVPKGTKITDHIIIGTPGKMLDWGVKFGMFDLSKIKVFVLDEADVMIDRQGHQDQCIKIHKCLPPTCQMMFFSATYDSAVMVFAEVIVPNPIIIRLLREEESLDNIKQYYVKCKNSDDKYRAICNIYGVITIGQAIIFCHTRKTAGWLSEKMSRDGHSVAVLSGELTVEQRIAVLDRFRAGLEKVLITTNVLSRGIDVEQVTLVVNFDMPMDLNKKADCETYLHRIGRTGRFGKAGIAINLIDSSQAMQICLDIEAHFGKKIHLLDIEDAEEIEKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH30</accession>
    <name>A0A194RH30_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH30"/>
    <dbReference type="FunCoup" id="A0A194RH30">
        <property type="interactions" value="1753"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH30"/>
    <dbReference type="InParanoid" id="A0A194RH30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="10">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="628" mass="73158" checksum="CCA2416CB95BB87D" modified="2016-10-05" version="1">MVVEVNLSYQGEDPGAVQYGNFINYYSFHNSNQRIEGLHASMFPNFDTNEDIICLDIGCNTGELTKEVYDYLKNKIYPKSSCHILGVDIDPILIQRAKDHINISDITFIKSNIMNEVDQNIIAQYLNSFNRKKFDIVFCFSVTMWLHINSGDEEFINFLKSIKDYTNSLIIEPQPWKCYRNAQRRMKKSGSHFPLYESLKIRSNVELVIEDTLVKNGLSNPRFRHWSPQFRPRGQFLRRNYTTNHFRYSGPQEQNNYEFWCETCDKGFQSLHILENHKKQHQKCNIDGCQFVAHPKIITKHIQMQHSTGLYKKIAKLNNPEEIRKWREERKLKYPTKKNIEKKAAELKEKIERGEKMGMNYQKHNRHGKPELHSRKQHNHTMSKGREKIQSRHKNNKFKNENPICHKKPPAPKKVCRTIPQPDNTQRLNPFAGIQQIIIEDNHDEEIEESLQNSLIEDDDIFTEVGTNKLNGKSQVCGALSSLMNEYGSSDEDVSNAVSNSINGNVKHLVDLTKTETKKEIIEKKLPIPVNNKSDDDSGPEETVITKSATDHNVDESSSNNLKPKLENRFRSPLNIKHYKKPKYQLPSTLLVKLLSREIEQERNIILQCVRHIVKNNYFDTKTTSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHB2</accession>
    <name>A0A194RHB2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHB2"/>
    <dbReference type="InParanoid" id="A0A194RHB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18396" checksum="29C9CCEFA1E2665F" modified="2016-10-05" version="1">MGILITKDTRRISFVNTIEINPALLVEKSIEDQDSFVQNNLEVDCTDELAFDEIIPCKEIQDEEQKYWSGRIESLKNEHQMITKIIEAEYEKTIENTNKLYEEPIITEEKIEKIKPCYNWRTKMLQCYESNPHQPLVCSPVVKAFNDYIETCRLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI55</accession>
    <name>A0A194RI55_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Little elongation complex subunit 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI55"/>
    <dbReference type="STRING" id="76193.A0A194RI55"/>
    <dbReference type="InParanoid" id="A0A194RI55"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019535">
        <property type="entry name" value="ICE2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10505">
        <property type="entry name" value="NARG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Little elongation complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="235" mass="25798" checksum="2851C6E4AE1A55D7" modified="2016-10-05" version="1">MKSKKKYSINNIIIANGDKQNSVGEVVLEAVPEYQLELGASELSSHTISSLALSLMLRRHATLMTVTVPYYYNVSVLHIVVRQNSVGEVVLEAVPEYQLELGASELSSHTISSLALSLMLRRHATLMTVRVDGQSGEVVRVDSNNLEELRAEHPTAGAAEAAHTLGTTLAQLQGLLPGHYLLRHEVLLKAVCRRYRKILPCAFTPHELQVAKETKKPAARQKPPPHAITVSMSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIL4</accession>
    <name>A0A194RIL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein unc-13-like B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIL4"/>
    <dbReference type="STRING" id="76193.A0A194RIL4"/>
    <dbReference type="InParanoid" id="A0A194RIL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MHD1" evidence="4">
        <location>
            <begin position="331"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="5">
        <location>
            <begin position="580"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="766"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="942" mass="106820" checksum="6F00D8DE8A1640C0" modified="2016-10-05" version="1">MFSFQYTCLHENLFHYLCEENGGAVTLPAARGDDAWKIYFNEIPEEIVDEFAMRYGIEAIYQAMTHFHCLSTKYLCAGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNLGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSAEKLMDLKSTVDLLTSITFFRMKKEKFVKLLDQLHNSLRIDLSMYRNNFPASSAEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRDPSDHGPQLDSVDFWHKLIALIVSVIEEDRNSYAPVLNQFPQELNIGQLSAATMWSLFAVDMKYALEEHEQHRLCKSSAYMNLHFKVKWLHTNYVKDVPPYCGAVPEYPAWFEPFVMQWLNENDDVSLEYLNGAFNRDKRDGFQKSSEHALFSNSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMKRFAKTIVKVLVAYADIVKKEFPEHLKEERVACILMNNIQQLRVQLEKMFEAMGGTKLERDAADILHDLQQSLNTTLDELASMFANSLEIRITASVKELGELLQKVGGGAAPGQPQPPAHHEADEVLRPLMDILDGSLTMYAESCEKTVLKRLLKELWKIVMKILEKTVVLPPMTDKTMMLKNLTNNAKNLAANAKIEDMTQLFKSTVGKQDVKHALSGVMDISKEHLSAEKSLTPKQCAVLDAALDTIKLYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQTTDTLIRTFVTSQQNQDAAVAEEGSVGEVSLQVDLFTHPGTGEHKITVKVVAANDLKWVIASGMFRPFIEVNLIGPHLADKKRKFATKSKSNNWSPKFNETFHFMVSATEQLELFELHVCVRDYCFAREDRLVGLAVMRLADIAEQGSCACWLPLGTRVKMDETGWTILRILSQRHSDEVAREFVKLKSEMRSEAPTGSQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIU1</accession>
    <name>A0A194RIU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Connectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIU1"/>
    <dbReference type="STRING" id="76193.A0A194RIU1"/>
    <dbReference type="InParanoid" id="A0A194RIU1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265243" evidence="4">
        <location>
            <begin position="23"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="527" mass="60802" checksum="9EEDDFCE078092AD" modified="2016-10-05" version="1">MAFKFLIIIIAFATIKINLTESRQSDKRRWKTDKSLYSHYVNICDIQDRVSKVHCYCENIKLKTATKADCWVFNGGIAEDDPFWSNFYSQPMIEKLSFNVRADGGLTYIPAKIIVRLERLQNLNIQYANIQSIPSFAFTNSTSLRDIMLPKNKIVKLERMSFAHLIMLSNVSLIENQISELQRDTFYDLPNLQRLYLSKNKIEVIHEGCFKHLNNLIKLDLSSNLLAVVVRENFQGLSNLMNLDMRNNKLMMIGDLAFTELWSLHELYLDNNEIEFISERGFGGLTQLRKLSIADNKLASLDGNVFNDVQKLYVLDLRNNYLEYFKEETLINLIENFKSNYALIALNGNKLTCDCSLAWLQKLRNETRSKRVKVALTRLSCISDMKPKSNGSTGRDKSNGHVYKGNTMSLKNNLDKSYEETEVNVEDDTVYEDTMQDQDNELNGNKIEYRRKLIDIPGEALPCPSRLSFEASFSPPTQDEVKYYKSSASKKVNRYDLGSFKKRAYHHLKGQQRICDSSGIAHDHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJB4</accession>
    <name>A0A194RJB4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_08616</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJB4"/>
    <dbReference type="InParanoid" id="A0A194RJB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="67"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="21062" checksum="8EABA93CB3131E98" modified="2016-10-05" version="1">MGSYQKGVANEVHMNQKSVSRCIREVTKALNEISNKWIQFPQTSTQRTKIKQGFYTKFNFPGVIGAIDCTHVAIVRPAADVLCFYNRKGFHSLNVQMVCDSDLRITNVNAKFGGASHDSHIWASRRLQSHMEALQLSGKSVWLLGDSGYPQRIYLMTPILNAEPGSRGENYTRVHVKARNCIERAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJC2</accession>
    <name>A0A194RJC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJC2"/>
    <dbReference type="InParanoid" id="A0A194RJC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="10343" checksum="968E54529D52E11F" modified="2016-10-05" version="1">MLDGLLLGGREAKFFISHPVNKPNPEAYEIRIFRYVNDEFMIYEECSLSGFTRWLISRNRNPTDEELQKIIASENDLKRLDSQKFCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJN7</accession>
    <name>A0A194RJN7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional repressor CTCF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJN7"/>
    <dbReference type="InParanoid" id="A0A194RJN7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000373">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002321">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000049">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000875">
        <property type="entry name" value="zinc finger protein 236 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN 672-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ18043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="476" mass="55385" checksum="924FE9050BA60CEE" modified="2016-10-05" version="1">MTTKSIVKPMQVQEIDVKEIDIMVENCNNECEGVTMMPLKNISGDINYVIMVQEDTMQANNNIQYDGIQIYECDKNENLNIDTNNIKADATDKKANTKHFRGHFECSFCSYIATRRYLLLRHVKSHSEVRQHKCDVCGRGFKTASSLQNHINMHYGVKPHLCKYCNTSYTTSGELIRHIRYKHTHEKPHKCNECDYASVELSKLRRHLRCHTGERPYQCPHCTYASADTFKLKRHLRTHTGEKPYKCEHCNMKFTQSNSLKSHKQIHNATERQVFACDVCPTKCGRMTDLRIHIQKLHTSADQPFKCKICDEMFPDRYTWKIHHKTHKGEKCYKSKICSFAGCSMARLKTHMLMHMDIKPFACKQCEQRFRQKQLLRRHENLYHKPGYVRPPSKEKTHSCHECGRAFAYPGNLSRHLSFHEPKPAPSEQVVIPDRIKEVQCISGQPKVGEEQEVEDAEDVKNNLITNVDTCFGFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK49</accession>
    <name>A0A194RK49_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK49"/>
    <dbReference type="InParanoid" id="A0A194RK49"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="259" mass="29417" checksum="8A9EA30D693EA4F2" modified="2016-10-05" version="1">MLKNLVDEYKDKSQDYRPTYALMRKVFRAAMASFQVFVCIYITTINSEPTGRACYHAKVCVHNAVEKCGIDSKGKLRRFIDSCDIKEYNCLKGTDFEKTLFEKCASLPSPKEDRKKQDKMKTKDNEEVDSQSQESSETTTKKSVGSKNQNNNSKKKKVKADKKEENLKVEKEDSAITDQEEGSVPQVNPDQANGVSGENVEKVKRGPERNNKNKNVSKSQSNVENDGTDSEENVKDNDNSQNNDNDEHDEEVHEDNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKF9</accession>
    <name>A0A194RKF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine/arginine-rich splicing factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKF9"/>
    <dbReference type="STRING" id="76193.A0A194RKF9"/>
    <dbReference type="InParanoid" id="A0A194RKF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000420">
        <property type="entry name" value="serine-arginine protein 55 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="402" mass="47269" checksum="5577DAD361343A0B" modified="2016-10-05" version="1">MFHDEYETSIFYKLKEGLNIPDLTMVGSRVYVGGLPFGVRDRDLEKFFKGFGRIRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVVEPARGIDRSADRNRRDRHYERDRGRSRYDDYNYRYGPPTRTEYRLIVENLSSRISWQDLKDYMRQAGEVTYADAHKQHLVKLVVEFATHSDMRAAIEKLDGTELNGRRIRLVEDRRSSRRRTRSSSSRSRSRSRDRRRSRSRSRSRRSSRSRSRSKSRPKTKSPVAKSRSRSRSKERSHSKSASASPQRKSDRERSPQHSADRNGRERSREQSRSRSRERSRERSRSRSKSRSPRADKERSRSRSKEAQSPKREEERRATKSRSRSRSRSASRDRSRSRSRSRSRSASPRQNGTGQDRASTDRSPRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKY1</accession>
    <name>A0A194RKY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKY1"/>
    <dbReference type="FunCoup" id="A0A194RKY1">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKY1"/>
    <dbReference type="InParanoid" id="A0A194RKY1"/>
    <dbReference type="OrthoDB" id="636773at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18488">
        <property type="entry name" value="BACK_BTBD3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18282">
        <property type="entry name" value="BTB_POZ_BTBD3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000003">
        <property type="entry name" value="BTB/POZ domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.820:FF:000001">
        <property type="entry name" value="BTB/POZ domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000015">
        <property type="entry name" value="BTB/POZ domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049737">
        <property type="entry name" value="Btbd6a-like_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF9">
        <property type="entry name" value="LUTE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="535" mass="58997" checksum="08C16EF7E9C9BE15" modified="2016-10-05" version="1">MSNLCSRIVSKPPKRLQDNRDSMSVAQTNTWMNAENINNGGGISLSPPHTVSQRETATQVSQCYSGPPSPCGSSSSASSPTVSPAPPPGTATLDPNWQATKPTVRERNAAMFNNQLMADITFIVGSPGHTQIIPAHKYVLATGSSVFYAMFYGGLAECKPEIEVPDVEPSAFLTLLKYLYCDEIQLEADTVLSTLYVAKKYFVPHLARACVNYLETSLTAKNACLLLSQSRFFEEPELMQRCWEVIDAQAEIALTSEGFVDIDVSTLESVLARETLNSKEINLFEAALAWAQAECVRREIETTPANKRAMLGSAIYLIRFPTMTLEEFANSAAQLGILTPQETIDIFLHFTAANKPQLSYPIKQRAGLKAQICHRFQSCAYRSNQWRYRGRCDSIQFCVDKRIFVVGFGLYGSSNGAADYNVKIELKRLGRVLAENNTKFFSDGSSNTFHVYFENPIQIEPECFYTASAILDGSELSYFGQEGLSEVYMGTVTFQFHCSSESTNGTGVQGGQIPELIYYGPTMNTSLPNPNASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL33</accession>
    <name>A0A194RL33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL33"/>
    <dbReference type="InParanoid" id="A0A194RL33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="13346" checksum="81D251012C8ADD80" modified="2016-10-05" version="1">MIFSRAFSGGIKPTRLWYLTGMKHFKKMLDSRHEAGNRPFYPRDRPQLLQLIAFNLAVVGGILYSYGWFTPKVCPGGDETDASGKQKICKNIKGQPCPVDENGRMPEKCPEPNKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLN6</accession>
    <name>A0A194RLN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Harmonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLN6"/>
    <dbReference type="STRING" id="76193.A0A194RLN6"/>
    <dbReference type="InParanoid" id="A0A194RLN6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ16896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="546" mass="60024" checksum="0F4999956544AF86" modified="2016-10-05" version="1">MYSTSTASTTTSGSRGEPAVGPMERRVRVVRLLRPRRAAPAFGFALRGGREYATGFFVSKVDINSEAHLQGLKVGDQIVSVNGYRVEDAVHAELAHYLTSQSRLKIKVRHVGMIPVKEKDHEPLSWQFVSERASLSSAASSSPTLCDLAERLTDMRLSILVPPRAKLGCGICKGPDWKPGIFVQFVREGGIAREAGLRPGDQILSCNGQDFANISFNEAISAMKVSGRLELVIHEGAGTELVSPESSGYNSSASSAAGERSPAPAPAPLPLALAPPAALRRKLASVAEEAADRADRLTMNRIKRRTWDSLDFKWKNDDTHNFDAPSDIEPDYDSPSIPNNPHSYEKKTNLRKNKTDYEPARVTSPLNRTIINLTEDGATIQCSYDNNQTPRKNVFTNETNRDKEKKTIVVEVHHVAPPACANTQLNFPPPMKKDINSDTSSISSTATLSSAIAEEIQRRKMNKKPPVEIPPVLNQVKKPIAPKPVDDKKKQHDALMDEFKKVHRKMFANQDANDATLTEDCTDGVSNEATVRATQSEVLRRVCSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNL9</accession>
    <name>A0A194RNL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ryanodine receptor 44F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_07099</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RNL9">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNL9"/>
    <dbReference type="InParanoid" id="A0A194RNL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000132">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2226"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2422"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2505"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2692"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2768"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="domain" description="RIH" evidence="12">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor Ryr" evidence="13">
        <location>
            <begin position="557"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor Ryr" evidence="13">
        <location>
            <begin position="677"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="RyR/IP3R Homology associated" evidence="15">
        <location>
            <begin position="1772"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine Receptor TM 4-6" evidence="14">
        <location>
            <begin position="2263"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="2654"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1359"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1627"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2316"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1369"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1629"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ17611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2892" mass="327532" checksum="24960E5D3F5B93A2" modified="2016-10-05" version="1">MAVMMNTLGRRAQAQSDAQPANPPAADDTSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLKAIVDANKMSERIADRRKLRDLEQEGDINFSHPLPESDDDEDYIDTGAAILNFYCTLVDLLGRCAPDASVIALGKNESLRARAILRSLVPLEDLQGVLSLRFTLNNPAAGEERPKSDMPSGLIPGHKQSVGLFLERVYGIETQELFYRLLEEAFLPDLRAATMLDRNDGCESDMALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYERCAKYYGSTGGQGVYGASSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCALPPDYSLSKNYDDEFYGKENQATGADNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAWASRKIENGWVYGESWSDSQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSTNRSSMRRQSKSGGTDSATPFNYNPQPVDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELVVNGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPSKATQIDTEQTTTGVAIELRFAYSLLEKLIQYIDRATINMKLLKPSTTFSRRPSFKTSTRDIKFFSKVVLPLMEKYFSTHRNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNVADDLGHTILNLQEGKYAHLRGTHLKTSTSLGYINGVLLPVLTAMFDHLANCEYGADLLLDEIQVASYKMLGSLYTLGTDAMLTHDRKYLKTEIERNKPALGSCLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMAKMEQSMPTLETILNEVDQFVESDKTYNEAPHIIDVVLPLLCSYLPFWWAQGPDNVTPTGGNHVTMVTAEHMNQLLKNVLKLIKKNIGNESAPWMTRIATYTQQIIINSSEELLRDSFLPLAERVRKRTDTMFHKEESLRGFIKSSTDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRNNSSTDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRNNVPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVLIMPTATRRVTTIVDGTPQGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMSEQDVAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKTTITVETAENKAKIIDDTVERIVAMSKVLFGLHMIDHPQQMSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRACNIFARTYYELWLEEENTGQEVMIEDLTQSFEEAELKKSDVVEEEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYAHIIAKSCGEEEEEGGGEEEEAGGEAEGEEEGGASIHEQEMEKQKLLFHQARLADRGVAEMVLLHISASKGVPSDMVMKTLQLGISILRGGNIDIQMGMLNHLKDKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKMKDLTSSPSFQEIDANNDGWVLPKDFKEKMEQQKSYTPEEIEFLLACCETNHDGKLDYIGFCDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEIMGGSKRIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMAASEESSGGPKNREAAYMYMGDDDDERAGKDPFRRGFQSVKDGISAAFSSLSPSNIKAKIADLQQMPPAELALGFFKMFFYLFYYLGYGVLVVVRYIFGVLLGLMRGPQTDEPPPEPTEEEKIGQLRHRFLSQQQSPSRHLPALPPADDTGQMQVSAFGLDITKEDNGQIQVKPHESPSTSTPSSGEEAEVSPDEGTEHTEEQQPPSLIDLLGGEQAKKQAQERMEAQAAQQAAMSAIEAESKKAVQGPAPSALSQVDLSQYTRRAVSFLARNFYNLKYVALVLAFCINFVLLFYKVSTLEGDGVEGSGLGGIMAGSGSGSGAGSGDGSGESGEDDDPLEVVHIDEDFFYMEHLLKVAAVLHSVVSLAILIGYYHLKVPLAIFKREKEIARKLEFDGLYIAEQPDDDDLKSHWDKLVISAKSFPVNYWDKFVKKKVRAKYSETYDFDSISNMLGMEKTSFSAQEDEGSKGFLHYIINIDWRYQVWKAGVTITDNSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYVQEEDDEVNRNCHDMLTCFVFNLYKGVRAGGGIGDELEPPDGDDGEVYRIIFDISFFFFIIVILLAILQGLIIDAFGELRDQLESVKEDMESNCFICGINKDYFDKVPHGFDTHVQREHNLANYMFFVMHLINKPDTEYTGQETYVWNMYTQRCWDFFPVGDCFRKQYEDVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS56</accession>
    <name>A0A194RS56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RS56"/>
    <dbReference type="InParanoid" id="A0A194RS56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032055">
        <property type="entry name" value="TMEM72"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16054">
        <property type="entry name" value="TMEM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="33895" checksum="61C0977262D54AFF" modified="2016-10-05" version="1">MSVESSKPIRSDAGEPEPQDTTIRSPSIRVTAPKKSLALRLWVLLQPLARLWGLITAVVLSGAGAELMVLGYEVAPGFLVGAALVFLLETMWVAALFVDLLCRRGQYTLSLRCWDFARWSCGRARAPFYACAATSILFANLTILAAVAAVTYIFFDPPNDDHDRRNARRRGKRGKRWVPGVVRARPSRDESVVLRGYGLQIYNAAHSADDSETGSCEMQRLLSPQHRQQEHLTYARRHALPLTLHYRISHAPCLQIDIRKYYAPATCFTNEPTRPVRRPWTCVHDHTEERREVELIPCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAS1</accession>
    <name>A0A0N0PAS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Cyclin-dependent kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_03487</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAS1"/>
    <dbReference type="FunCoup" id="A0A0N0PAS1">
        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAS1"/>
    <dbReference type="InParanoid" id="A0A0N0PAS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051446">
        <property type="term" value="P:positive regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="215"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ07774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="529" mass="60906" checksum="54F4C0CABC6FE9D5" modified="2015-12-09" version="1">MDDFLKIEKIGEGTYGVVYKGKNKITGQFVAMKKIRLESDDEGVPSTAIREISLLKELNHPNIVKLEDVLMEESRLYLIFEFLAMDLKKYMDSLGSGKFMDPAVVKSYLFQINNAILYCHQRRILHRDLKPQNLLIDKTGIIKVADFGLGRAFGVPVRVYTHEVVTLWYRAPEVLLGSLREQTLCGSSSGGEEKRLLPSDEMVVRETRLFEMDDFLKIEKIGEGTYGVVYKGKNKITGQFVAMKKIRLESDDEGVPSTAIREISLLKELNHPNIVKLEDVLMEESRLYLIFEFLAMDLKKYMDSLGSGKFMDPAVVKSYLFQINNAILYCHQRRILHRDLKPQNLLIDKTGIIKVADFGLGRAFGVPVRVYTHEVVTLWYRAPEVLLGSLRYSCPIDMWAVGCIFSEMSSKKPLFQGDSEIDQLFRIFRMLRTPTEEIWPGVTAMPDYKPTFPNWNTFNLHNHVQNLDETGMDLLQKMLIYDPMRRISAKDARRHRYFRDVVIPPGLAVHKAYIRYSPEYNETDNAQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB77</accession>
    <name>A0A0N0PB77_PAPMA</name>
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        <submittedName>
            <fullName evidence="11">Orexin receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PB77"/>
    <dbReference type="InParanoid" id="A0A0N0PB77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12830" checksum="24FF4854BF0E4E21" modified="2015-12-09" version="1">MSNENFTEYAEIPYYIKATSMTFCIVIMCLGVIGNVMVPIVILKTKDMRNSTNIFLVNLSIADLMVLLVCTPTVLVEVNSKPETWVLGKELCEYYFKLFDHYKINGFDGRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBE7</accession>
    <name>A0A0N0PBE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP and coiled-coil domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460954">
        <property type="protein sequence ID" value="KPJ10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBE7"/>
    <dbReference type="FunCoup" id="A0A0N0PBE7">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBE7"/>
    <dbReference type="InParanoid" id="A0A0N0PBE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="507"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="718" mass="83596" checksum="862ED7DF4B45077C" modified="2015-12-09" version="1">MESLSKQELISTITKQADQIKRYEARLRDVVAAYKGLVKEKEALEISLKALSRGDKDSGQGSEDSVTTLMQSLATLTAEKSRMEEAFQADKKVTREKYENMLASMREETKTLVQQHLVEVSNLKAKIAYEIQERENERADHAAMMNNLKAKIAYEIQERENERVDHAAMMKELHAKLTSERKNKERLEDKVVNTSEAQASQAELEKRVRDLSSSLEASQRRLQRAEARTVETPALLVRLQQKLALLEQSHSIAIREEQIKAKRAEESARKICARQEERVALLEGKLAELSQTIGEYDLRRRKDQQTIQQLKNRLMAVFWIKWLPDVEQIKAKRAEESARKICARQEERVALLEGKLAELSQTIGEYDLRRRKDQQTIQQLKESLNGSLLDKMATRRDEFQQKSETDNEKLADSEYLQTLIDKIHILKKELIAENIKLGNPVDITTVFKVDGYDNVHDKCKEELEKLKLDFENYKAQNIKRSHDDDVTEVDDLKTEIVVLKEKVETFKLMWEEEKQDKEDSLKLYEEKLKSEREYHKEVTSELKSRVQTLERQTQAQRERYATLLEETDTYMRTRSERARKLSSEELLKEGHGMLNEGSAPPHMLHYAHELARKDLDITQLRKEKHLLEGHYRDCQRDATIEKERFKEVIRTLKEEIDRWQTSERPPEFAEIATRPLPIDICNLYLSVIDGEGDAQKEYFPSLHIPSCIKSPSLPILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBG0</accession>
    <name>A0A0N0PBG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03814</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBG0"/>
    <dbReference type="FunCoup" id="A0A0N0PBG0">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBG0"/>
    <dbReference type="KEGG" id="pmac:106716224"/>
    <dbReference type="InParanoid" id="A0A0N0PBG0"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ10026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="294" mass="34119" checksum="C937474CE11027EB" modified="2015-12-09" version="1">MTDERNFRSAYYEKVGCRGVEEKKSLEILMKEKPWDKVKLKQFCLRFMVPASYRNLVWKVLLDIIPVYADSHQFVMEQRKQQYGDLLYAVDMLELVDMSAPRTEILLAMWLLENEERKPPLFPETNFNSADTFLPIAKTLIELYDNEVDVYWLCKSLTEIVRNMQKDIPKLKEAFQSMLEKEDVELFNHLVDMNALDVLPLTKWFNSCFAGVLDVTSLPKIWDKVCSGAPKILSVVAVMLVITLRRNILKAQNGDEVLKCVSEIPEQCEEVVANKAIELWQYGAQPQNDQLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDH2</accession>
    <name>A0A0N0PDH2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoacylase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460339">
        <property type="protein sequence ID" value="KPJ15642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDH2"/>
    <dbReference type="STRING" id="76193.A0A0N0PDH2"/>
    <dbReference type="InParanoid" id="A0A0N0PDH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="213" mass="24296" checksum="3F2C373BA1859BB7" modified="2015-12-09" version="1">MKSVAVQYLEAVRRLKNKRIRLKRTVHLSFVPDEEVGGAKGMAEFVKTDHYKNLRVGFALDEGIACANEEYQVFNGERTIWHLNVVCPGKSGHGSLLLPDTCGEKVAKDNDRDDVMFYTEILVSETNDINPKIATNSRALKMIDQVTKLWTNFAKYGNPTPDESLGVIWKPYTLEGQDFLEIGENLVAGTRPDKDELEFWERIYMKYCPKYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PET6</accession>
    <name>A0A0N0PET6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459805">
        <property type="protein sequence ID" value="KPJ19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PET6"/>
    <dbReference type="STRING" id="76193.A0A0N0PET6"/>
    <dbReference type="InParanoid" id="A0A0N0PET6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="354" mass="41413" checksum="BCEE0569204FC38D" modified="2015-12-09" version="1">MKDPDLLRDHTAKVHQFANLELVVFDRTKNNRNRDAAVKIDVTDICCKLCYKQVNNLEQLIHHLIIAHDAEYDVSVPNCLLPFKLDKDQPTCPICDMKFVFFEYLLRHSNKHHLSHDYICDICGTSFQGENHLKMHNRYYHREGGYTCEHCGITLATLSKKILHEKNVHMINLSTCPHCPETFKSPYFKKLHLANVHGVEELKIKCPYCPKVYPQESIMSRHMRRVHLREKNVECEVCGDKFFGPYDVKLHMLKHNGDKKFVCAVCGRKFSKKNNLNTHLITHTDRKFSCDICNKEFTNQQYLKAHVKKHSDIKNLNESEQKIILDDLNETEIIQMEFVNDEIEGAELTGQYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFP9</accession>
    <name>A0A0N0PFP9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="LADJ01050554">
        <property type="protein sequence ID" value="KPJ21491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFP9"/>
    <dbReference type="STRING" id="76193.A0A0N0PFP9"/>
    <dbReference type="InParanoid" id="A0A0N0PFP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="160"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="28933" checksum="552E3B759D3BD77C" modified="2015-12-09" version="1">MVTSSSLLQPFLQKPLHPPLHSSFSTPSMVTASSLLESFLHKPLNLPLHSSFSTPSINGRWIFDKFVCNCCLLNLNSGEIRYTKNGEDLGIAFKLDQSRKSDCYFPAVVLKNAEMSFNFGATPFKHTPPKDYVALCNAPKECVKLNVVSSVQSTDSKPVNNAPQAIIIEPSRELAEQTCNQITKFKKYLENPKVRELLVVGGINVKDQINQLNAGIDIVVGTPGRLEDLIQGADRAPAPTDPEDHQRWTTSADGGLLGYFTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFS7</accession>
    <name>A0A0N0PFS7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01058387">
        <property type="protein sequence ID" value="KPJ21594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFS7"/>
    <dbReference type="STRING" id="76193.A0A0N0PFS7"/>
    <dbReference type="InParanoid" id="A0A0N0PFS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box helicase OB fold" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="112" mass="13456" checksum="B2AB696396DC8952" modified="2015-12-09" version="1">MIIFHRNREWRIAIKSVAHLERTGHYLTVKDNQVVQLHPSTCLDHKPDWVIYNEFVLTTKNYIRTVTDIKPEWLLKIAPQYYELNNFPQCEARRQLELLQARLDSKAYQEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I511</accession>
    <name>A0A0N1I511_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folliculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I511"/>
    <dbReference type="FunCoup" id="A0A0N1I511">
        <property type="interactions" value="1122"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I511"/>
    <dbReference type="InParanoid" id="A0A0N1I511"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="36739" checksum="EA38F4EB66B62EAC" modified="2015-12-09" version="1">MNAIIGLCHFCEAHGPRPLFCTFTTDDENHTTESSQCSVQCSGCTSLGPETVLVSRDDDGTIYCSRESVPNAEINTFLRQAAVRSITCEVSWSKEGGVVYFSDAQGHVLSLMFQVKDTRARGLKRWFSIVVLMKDKMLLLNLTPMLSEHMENISKELQHLADDVYEKEQSICSQRALRLKTGRNDFGQSRSLIQLTDDENVYKRLHSHFTWMLKTGALTYSETLYTSKDLLDKICPKTMKKTIFEQDICLSNYNCEISIRSLENLLTKSVFRILLYCILTGVDVSDIFFFICIFYKSLYKHNYNDSVTFWNIFVIIITQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6Z9</accession>
    <name>A0A0N1I6Z9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL/TRIO N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6Z9"/>
    <dbReference type="InParanoid" id="A0A0N1I6Z9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11534" checksum="615965CC4B9ED490" modified="2015-12-09" version="1">MPVELEFDYNAATAAMDIFSQDDINLLKQWTQKLDKSKYVPKDLSDKQLLLFYNACYGDLDKTKTCIEKYYSFRKNAPEFFDTRILNSEELWPSTEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I771</accession>
    <name>A0A0N1I771_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the riboflavin transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I771"/>
    <dbReference type="FunCoup" id="A0A0N1I771">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I771"/>
    <dbReference type="InParanoid" id="A0A0N1I771"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF10">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="453" mass="47803" checksum="0996A00CC42869EB" modified="2015-12-09" version="1">MTDTTNRTRVFLPATNATSFKEMTITEEKERVPCLGKGEAGGGGMVTRRRCVALDALLACWGLGAWLGVNGLYVQLPLLVQALPEGWSLPSAMALAVQLANVGLLAYAALRRLLPRAPDAAYIYGLLTIGTLALLLNSFLYTATTPVAGADRSVAFLTLTFFAALVGCTSSVLFYPYLRHFREVYLATYLAGEGLSGFIPSILALVQGVGGEPECVPGPDAETLVPVHPPARFDTSAFLLMLAGLSALSLVSFVGLHNLRAFDSERVPRAAVAKEEEAEAPRGSRTLWAAVMSLTLLLNALSNGVLPSVQSYSCMPYGVRAYHLATSLAAMANPAACLAGVWLRPASARMLAALLAVAAVPLAYLLAAALLSPAPPLHRHPAGEVLIVVSWVWAAASVSYARLWVCAWARRGGARGMRLCGAATQLGSALGSLLLFLLVTRTALFTQPAPCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7I4</accession>
    <name>A0A0N1I7I4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Putative G-protein coupled receptor 158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_04990</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7I4"/>
    <dbReference type="InParanoid" id="A0A0N1I7I4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12913">
        <property type="entry name" value="PDC1_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF29">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1092"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1115"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="19">
        <location>
            <begin position="469"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="843"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="907"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ10167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131246" checksum="2F2051C7D1CDFC1F" modified="2015-12-09" version="1">MFGLTKKLLCSRKIQSQSIDKSGEDPVVAALRPYSAPDEDEPKESAEPFHKLFGNFSGTKHKEEPIDDVSLLDHLYNVEHSYDNNETQKLTMEDILSVDNAKDSLFNDTLNDTDNVTIVRPTVHEDVVTKFLRLIETQHLLGENCTAGTHLNLGEGVVDRYAQERFRIEAEVAVNRANMLTRLWKYAGPSVMHNEYLLHASVFSMVEFDDDVFAAGNCYDQYQYKDYQLFCPFAYRLPEGPILAKDLAVEYKYLSNTSEWFYIARKNAERVIRNHNQFKRGYNTYTYNDTAHTEREFDEILSVTYEDGKWSKPYYDCGGGNIWMLTYTVPFFGYSNGTYFFKGTSGIDIDLRRVDIDQCPLKPGSTQLNIFAGTDKCKKKTTECVPVPGLGFRRGSYRCLCRRGFYFPNTTAEHRYYNGSDIEEEYEKHLLHQLSLYSKISAFECLPCAEGCEACVDGSPCVAALNWVVRSSILALACFVISCLPFIVYFTIKYGHVRVVRAASPALLRVIVLGAALIYCTTLVMYGRPTVFTCTLRVWLREVGFCLTYGALMLKTWRISMIFQVRSAKAVKISDMYLLRRIGVIVGVACVLLSIRTLVAPPAVIVGRTREDLKAYLCNTDWWDHSFTTLEVIFLMWGIRLCIMVRKAPSDFNESRFISMAIYNEFLLSGFLNISMLFLQSPANPDLLYIIFFCHTQLTVTLLLLFIFGSKAYMVFRGHGKDDREKTGKFRTRPADSTYTMTTNNTHFCDNMTERELEEEFKKLCNQLDKLRERCGSSSNIARCITEMQDAAIRNERRGNTNEHSAPLRLNNVFNAVAGRLMCNVTPGEESSSSGRDIVFEAPPAYRQRATPTKSGETSNAEQSQTDVTTDSPKKKDDQESKEEAQNGVFRISGEANCSDVRPPDVSNINAPSTSTANRNPLSTNIIRNLPSTSSTDRNAPSTSTDSRNVPSTSTVDRNLPCTSATNRNVPSTSTDSRNVPSTSTTNRDIPSTSTVNRNVPSTSTSNRNISSTSNSDRSETRTSPNASESVRGGVRSGHARTHAIVINLDDKSRFTEEVTLTMSQASCNQYASESKKAVELFRSWLQTHEEAQIMVGSVLIVFGLWWLARTLFALIVNLLCPLLFVLLAVICVPQLRVSLLGQNYPIVANLLRSILLKMADSLSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC12</accession>
    <name>A0A0N1IC12_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA topoisomerase</fullName>
            <ecNumber evidence="1">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="1"/>
    <dbReference type="EMBL" id="LADJ01003315">
        <property type="protein sequence ID" value="KPJ20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC12"/>
    <dbReference type="STRING" id="76193.A0A0N1IC12"/>
    <dbReference type="InParanoid" id="A0A0N1IC12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15427" checksum="5460ECC95B80914D" modified="2015-12-09" version="1">MLLYFIGRYGDLDASLISYGPCQTPTLGFCVQRHDEIQTFKPETYWVLRVTASTDEGRELPLEWKRVRSFEKEIANMFLHGIKEIKEAVVINVQAKEKLKSRPVALNTVELMRVASSGLGMGPHHAMQVILYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICG0</accession>
    <name>A0A0N1ICG0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vitellogenin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICG0"/>
    <dbReference type="InParanoid" id="A0A0N1ICG0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.20:FF:000003">
        <property type="entry name" value="Vitellogenin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1430"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1470"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1617" mass="183528" checksum="852D029F0870BBB0" modified="2015-12-09" version="1">METDVTGDCQTLYTVSPVASEWRRELPKFAEEEEPIEITKSKNYGHCHHRVDYHFGVPEGAEWAGTAHRTGEDQLIKRATVSRILAGKQGPIYKAETTSTVHVHPLLHGKQKAEVLSQVKVTLDSQEQDSEPEWENPEGSRPIQNLLYSLTPKQVNIEDSSSSSSSSSSESHENRDQQGYNQDSPKNRQRRSSGLKKIVTANRVVIKKRSNDRSSSSDSSSSSQSNSAYINDDVPRSNEPAYAALYLNPQPHGDKKQNPMNAQKLVQEIAQQLQNPNNMPKGDFLSKFNILVRVIASMSSGQLSQTSRSIEIAKSSNNNLKSDMWMIYRDAVTQAGTLPAFQQIKTWIQTKKIQGEEAAEVTASLPNTLRYPTKELMAQFFELAMNDEVRQQRYLNNSALIAATKFINMGQVNNRTAHSYYPTHMYGRLSNKDDDFVLKQVLPRLQQELSQAVENDDRHKQQVYIKAIGNLGHRAILEVFAPYLEGQIKVSNYIRTQMVNNLQTLAKQEDNHARAVLFSILKNTAEHYEVRVAAIRNIFMGRPNSPMMQSMAEMTHHDPSIQVRAALKSTIESAAALKNPRYFELARTAQAAKDMLTKEEFGKQDSAKYFDENHDEDSENTILSVISQIGSRDNLWPKQLNYVMKNKAGGWDKPESISASVSSVQKVMDYLKEQLFGNNAKDNNDDVNHKYSAKKVAQMLNIKSNNAEPLGASFQINFMNQERFFAFDEGDLQMLAQSIKQYAQEFEKGVDKHYTKVFNQDQISVMFPVATGMPFIYKYKEPTVFHIMSKAKGQYEMKSPKEYSGSMDKDIHFTYAKNIDGSVGFLDTLSNQHSSAGVVTKFQLYIPIKMQVQVKTGEVQVSVSSLEPEQDHTILHYSSWPYTANQKKDTLTPISQDPTTKLVARNNKVVALDTKFGQQVGIQFQLQGYSYSNDFKSIRNKFDWDHPMSSIASAIYQKDIAQTHFNLKHLGKQSKNKDIKLTFAYDAYYNQKQDGQYNPTASDVKDVSPNSEERRKELVKRAVTGINTAKAQVVDFSVTFEGAQKVEYVATAAIGDSPVDDKVQYAIFAGKNSPQGNTQINGVGKHNKPESTTFNYQEALKKDLKMPFDLDIRYGPSGNIHMNGQVERSKKYGDELKNLPLAKQCDQEIAQGNQYQRACYQMIIRSQALDSLRTTVTYKDVSPAVKNFVFQAYKIAESLGYWQTEVNPFKTLPEGRLEYSIEASYLTNSLHLVLNSKYGEVQVKNMYIPDVAASVVSAYRPINTYERVSNHYSRQQYQPYCSVDGTRVKTFSGRSYEYPLTKSWHVVMLQDAEHPGQSNEQVAILARKPNSNEKQQELYISYKSEYGKQLEIEIQPTEGSKQQQVKVTTNAKKVSDGDLTMYWDDEEERPILQYHTESDGTLMLNIREDRLRIMYDGYRSVVLNRESRNSSRGICGQISGDKRDDYLTPNGLVDRPEHYGASYALDDENSDPKTKQLKEQAKEKAYEPEIHYTTILRSDQEWKNAMHSSSSSEEDWGSQSVYRSRSYSKQPGPCKVQQQVQYYENHGEICITTKPLNSCQSSCRGDGYKVQAAQVVCRPKLDQQFRAYRDQIKQGQNPQVNGVPQNKQFRVPSSCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICI3</accession>
    <name>A0A0N1ICI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICI3"/>
    <dbReference type="InParanoid" id="A0A0N1ICI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1620" mass="186863" checksum="5D7AD85CAF6E49DC" modified="2015-12-09" version="1">MSTIQALNKIKSFEIEYFSKYEENGAGIKIFDLLLLNPPSKTWDLLGKELILLLQYWLNALRKHLIIHNNNWWPFLQSILKFVKELGLKECKLNDVIVKETAECLLDLATHTRPDINQRYKILCALNACSIACSREIRVALRTHFEVYFIKLATLLSSCGDAAVQYSIMETLLRWLLPRYVQEVRRDAALKWFPTYLYDKETVTMFVERPWKDFFQDTRDFLNAHNARSDLITSVICKKLIIGQIVVITGSEKCYNWLDINTSTKCLTVMLEPRLLRTLGCGLHAEACEALVINEVNTDAAKLRKIAQEVTIFVKTLEPAHLIPSTISLSSENCKEIKIVVSTKCDMGKVDSALRRIFADKYQVLFDIENGIPISPQKNNTRQDTSEEDTTFSIPSVRPKRRTGYVVKSRTVASEILASSASTTSLAQLHEKLEELPYYEIKHDRMKIPYPGLSRITEASESDAGRSCGSSAFKLKSFGICQKSTFTQAEKSKTKEVKKTKLISPAITDEENSVSCLFVATIGSADESVINDTLERLPKNRNPENIIDVLVQEAFNANNVSCDKNNDNSDVPKEAGNTLNKPILKEITNENRANKRKSCTVISNSTSEEIVEGTQFSNTLFEKRNTKEFIMKESEIFPVKVSNDKVEEFFSQHFSNNPVTEVISPSIARKHNETESEPSEEDTRRKEDLKINDSDIDLDVELCLKFIIDTICNEFDRCEDLHETSIVDKHPNIQDSQEEIHEENTTKDTDDFKRRRFPTVKEAKSIKKITLKFKNPKKPNGKTQKKSKVKSNENSVMSKKVETAKNTKNISSVSDTSNNMDESIPKNKRTLRNKRKLYSPKDDEFNDKCDETENRSKVAQNTKTYNKTRTSITSYKEIEKERNEYRKKLRNKQSKENKLIFISPKTKKMNDIFDTLKSNIDTNQEVTLVNKTNTFGNVDVYNFSSDSEDNFKTSAVKHLSPKRSTLEKKSKQDKKKKTYSRKNAKSKPKLSIKIERPLIDERMREAPPETLDTSFELRRSPRNIAKEPIPNIETEHEMEVLQDVKTKHKANNKRVNTKLEKKKKSPLKNKKKNLNKITNYIKCNETFDTTVSPLPGLTVETIPNKNVANVSASPKRLEKIREMYAESPEKFENFNTTQNLLMDLDQTSECGVQEIEHCAEIHQNSQDNSQSSRILRSQKKQTPTKKVVVNKKNDLIKSIKKNKNKNKRRNEIDPTKYVIDISADSNSEISINTVGICPITAHGDFELCYKDLPPNQDILNKTIEPRNLEIEEQNESIKELYLQLQNERLEDQINQTWNRSFRNNIESVSTKKSTPLNITKISSDDYIKYLPSLRDSDTSSNHSVDELDKPRSYNSNKPVSRSKINSRISDNLNRNITLKSQISPIILFHDEQPNHNKSESNRSIDSDNIKQVRNLFYKTKLSNKSSTMKTRNSDINSSKRESLRDSVNKLVKRKSSELLEMNKKRKIESVLSNTPIHSSENISSSFVNNWFDQCIPSTSRDGRHNYDENVRCILEKLDTTLVEIHHNTDRRFIKTFVETQKRFSELKRVHHEVYEETLRDLNYKFKRLQEMSDEIFEEMKSRMRDVITQDRKQKIAMVKILKEDVQAVVDFNARRAKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDS7</accession>
    <name>A0A0N1IDS7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDS7"/>
    <dbReference type="FunCoup" id="A0A0N1IDS7">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IDS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873896" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="14385" checksum="C7056B286564E5F5" modified="2015-12-09" version="1">MMKFVFALCLALAVADATNVQRSRNMQSMRTLATAYLGAVPVPYNLGNNANTCNFLTNTRCPVSSGTSVNYTLRMYIESWFPVGTSGTIEFRIVDDRNQPVVCVRVPIRISRSGKFIEGESELPRGIEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IER9</accession>
    <name>A0A0N1IER9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IER9"/>
    <dbReference type="FunCoup" id="A0A0N1IER9">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IER9"/>
    <dbReference type="KEGG" id="pmac:106714679"/>
    <dbReference type="InParanoid" id="A0A0N1IER9"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF134">
        <property type="entry name" value="AT07769P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873911" evidence="8">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="282" mass="30410" checksum="4E962C8800C2AEAD" modified="2015-12-09" version="1">MFSFKLFTLFLLFGIVQCNSSYGYHILVGIPRARAIKIVEGMSRIVGGSQVTTLNSFPYQAGIVTTLTTGAESICGGSLVSKTRVLTAAHCWSDGQMQARKFTIVLGSLKIFSGGTRLDSTDVVVHPQWNFNEITNDIAMVKIAAVNLSENIQPVALPTTSELTENYAGLSGIASGYGKTRDSQNSFPSTTALYQVTLSVLTNEQCQQRFDMPLHSSHLCTDGVRGVGTCDGDSGGPLTVVWKNRRTLIGIVSFGLGDGCQLGLPSVYTRVTAFLPWIYSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II32</accession>
    <name>A0A0N1II32_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460393">
        <property type="protein sequence ID" value="KPJ15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II32"/>
    <dbReference type="STRING" id="76193.A0A0N1II32"/>
    <dbReference type="KEGG" id="pmac:106710481"/>
    <dbReference type="InParanoid" id="A0A0N1II32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="272" mass="31717" checksum="D6DB0D4A36BA9939" modified="2015-12-09" version="1">MSDKRKTFALPISKPVKSTQVQSSVRKTISTTKKRNVPRLNTTLCTKVNLADVTICKADDLQDYEEQYRQIAYGKFMRTMLEACLVREKFEREETEVDVQMCQLAERFNKTTDQLDKTSRRLKEISFIVEQKRLADLKSNDYTQFHEMSQKSNAEELLQNLASTEQALLDKLETKNVDFGYNKETGHKQLLDAVTDAIDGLAEIKKHSNLDVNKFKEYEKTQSTLNKLEREKFDLESMRLQFEKRFPNFNESLIKDASERISQLLDNNDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IID4</accession>
    <name>A0A0N1IID4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01061754">
        <property type="protein sequence ID" value="KPJ21623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IID4"/>
    <dbReference type="InParanoid" id="A0A0N1IID4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="6474" checksum="91238E1F651C8A81" modified="2015-12-09" version="1">MAAASSTAACAPVTSHGDHQGKLSLASKIHGLAERLQQLGKSSGDSVDGSEKGSRSRTGIIQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKJ6</accession>
    <name>A0A0N1IKJ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">omega-amidase</fullName>
            <ecNumber evidence="2">3.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nitrilase homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:32963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16769"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:32964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-oxosuccinamate + H2O = oxaloacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57735"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:59413"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="LADJ01006408">
        <property type="protein sequence ID" value="KPJ20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKJ6"/>
    <dbReference type="STRING" id="76193.A0A0N1IKJ6"/>
    <dbReference type="InParanoid" id="A0A0N1IKJ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7359" checksum="CFCE724DE5DEC27F" modified="2015-12-09" version="1">MTTGPKHWELLGRARATDLQLWVALVSPARDTSAGYVAWGYSTLIDPWGTPVAKLDEKAGTLFADIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INK7</accession>
    <name>A0A0N1INK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurogenic differentiation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INK7"/>
    <dbReference type="FunCoup" id="A0A0N1INK7">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INK7"/>
    <dbReference type="KEGG" id="pmac:106716158"/>
    <dbReference type="InParanoid" id="A0A0N1INK7"/>
    <dbReference type="OMA" id="AICYIRH"/>
    <dbReference type="OrthoDB" id="9946827at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000090">
        <property type="entry name" value="Salivary gland-expressed bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040259">
        <property type="entry name" value="Mesogenin/MesP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937:SF3">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="230" mass="27497" checksum="8E6B25671D281C25" modified="2015-12-09" version="1">MYNQTYEETPIPLVANYTIVKGVDEEKREEDRVILEIGRPDDRPREELTFSHKKYDKTISHHRSYVLDEYTEPRRITYFRPHELESLPQEGFQYNEYEGYRDAIVAQDAANSESSLDFSHESQDNSKYDDHQTDVTNWKERALQMEKEYKKTACDRERTRMRDMNRAFDLLRSKLPVTKPSKKKYSKIECLRIAICYIRHLEYMLSGGAPEDNPAFFELQAAERQKQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INR8</accession>
    <name>A0A0N1INR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 330-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOA36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INR8"/>
    <dbReference type="FunCoup" id="A0A0N1INR8">
        <property type="interactions" value="1171"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INR8"/>
    <dbReference type="KEGG" id="pmac:106715125"/>
    <dbReference type="InParanoid" id="A0A0N1INR8"/>
    <dbReference type="OMA" id="CFCDEHV"/>
    <dbReference type="OrthoDB" id="10258894at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010531">
        <property type="entry name" value="NOA36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06524">
        <property type="entry name" value="NOA36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="306" mass="34165" checksum="ECEDB6BC4EE6828F" modified="2015-12-09" version="1">MPKKKTGQRKKAEKQKQRQKEIRNAREHVDIAQHPCNMPMECDKCQKKQKSRAFCYFCQALQRLPACAHCGKVKCMLKSGDCVVRHPGVFTTGMGMVGAICDFCEAWVCHGRKCLQAHACTCPLTDAVCLECERGVWEHGGRVFRCCFCQGFLCEDDQFEHQASCQVLESETYKCQSCNRLGQYSCLRCKTCFCDEHVRRRGTRPDRRAAPPCPKCGFALLVTGELSMSTRSHRYGRQGAQPADDDDYGAGGYTGYEATAEGGDYSYSCSESDDDDDDEEDDSEEQESDDSEQTDTAATASGNNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INS2</accession>
    <name>A0A0N1INS2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INS2"/>
    <dbReference type="STRING" id="76193.A0A0N1INS2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BACK_BTBD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_BTBD1_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="50740" checksum="9F50126E59E92F3C" modified="2015-12-09" version="1">MASGSKNDIVNRLLNVRLEGGGDEQPPQNMLPSNQLARRLENVADEDNGRIPEAVPSSSSAIENLQPSNNTGRLHNWQATKTTVKERLSFLFNNEILSDVHFIVGRDANQQVIPAHKFVLSVGSAVFDAMFNGVLATKSEEVELPDVEPAAFLHLLKFLYSDEVRIGPESVMTTLYTAKKYAVAALEEHCVDFLKSNLGTDNAFLLLTQARLFDEPQLAALCLEMIDKNTVDALNAEGFTDIDQDTLNAVLERDTLRIREAKIFSAVLRWSEAECIRRQLPVTPGHQRAVLGRAFNAIRFPLMSVEEFAMGPAQSGLLDDREIVQLFLYFTVNPKPNVGFLDTPRCCMTGKELTVNRFPQTESRWGYSGTSDRIRFTVNQRIFVVGFGLYGSYFGPTEYEVHLQGTDSYYGTKGLRRVTVDGNNGEKVVFQFSYAAGNNNGTSVEDGQIPAIIFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB7</accession>
    <name>A0A0N1IPB7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor subfamily 2 group C member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_04482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A0N1IPB7">
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPB7"/>
    <dbReference type="InParanoid" id="A0A0N1IPB7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="224"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="488" mass="53729" checksum="8918C2147D9593C2" modified="2015-12-09" version="1">MRVRGEVGEERGAGSLPTALLFKTSYIMDAQDQMELKYSAGGEVGGLELCIVCGDRASGRHYGAISCEGCKGFFKRSIRKKLGYQCRGSMNCEVTKHHRNRCQYCRLQKCLACGMRSDSVQHERKPIVDKAKGEAREALHERPGAVYSKLLGLAGQAQTGQINPKEEPSEFGSVSPAPALNFALAAAVAFNKSAPVPYLPAGDDARRHLMLQTQLAKNLFKMGQFGAINEYLQSAYGSTPETPLSALHATDNQQPEGAGVDVGILSTAESQRLSLSLPAGAPPPLRLHAACEAGARLLHALARWTLAVPAAAALPFEIQATLLRKCWPELFVLGLSRCSSSLQLPSLLPHLAAHLQRELRARRDNQHLHHVRDARAELTIADYSEERISEVSALLSRLHQHLAALDLLRLTEREHAHLRALCLFSPGESNLTYIINVNDIITVILELEKEGRRVVMWNFEAKHQQLFEQISPDMKGKFFNGIAIEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPI5</accession>
    <name>A0A0N1IPI5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460474">
        <property type="protein sequence ID" value="KPJ14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPI5"/>
    <dbReference type="InParanoid" id="A0A0N1IPI5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="16621" checksum="AD7A934E2C647441" modified="2015-12-09" version="1">MTTKNINVENLISLVQNRPVLWDKTLEIYKDKNLRTAGWREICINLNEDFEEMEEKNRQDYADTHDSATIVTPNPADDSTAATVTSDVTHDSAMALDNLFGEDVANNQDATDESQQESNNENLVGGSKRKKSRPSRQNLNVFDKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ81</accession>
    <name>A0A0N1IQ81_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ81"/>
    <dbReference type="InParanoid" id="A0A0N1IQ81"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="25279" checksum="7173F52DC227BCD6" modified="2015-12-09" version="1">MVKLDELQKITQNLDQELAESQKIMKEIKTMFDAASQVNVAQVNNKKQDNIVTHTITTELLGASVPNLIMSDMENVSGHQSSQEELQSLIAIMKNYAENLRNEIARLPSQTFGNAKEFEKLDLKEYAINFDQLAKSLANIKFNKGVVNNRNLELEAKLAQLCEDVHSFTQMVETKTAISESNKNWTDNQQGNEQRNALYYDETINKLLNGINEVTYLLKNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQQ0</accession>
    <name>A0A0N1IQQ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01051523">
        <property type="protein sequence ID" value="KPJ21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQQ0"/>
    <dbReference type="STRING" id="76193.A0A0N1IQQ0"/>
    <dbReference type="InParanoid" id="A0A0N1IQQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="146" mass="16454" checksum="177A380E9D650F8D" modified="2015-12-09" version="1">MRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHSGYLSCCRFLDDNQILTSSGDMTWGMDLAEEETNWKEKYPLSVRPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PET1</accession>
    <name>A0A0N1PET1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PET1"/>
    <dbReference type="InParanoid" id="A0A0N1PET1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="333" mass="39415" checksum="BF0ADF1D8BABD276" modified="2015-12-09" version="1">MAKALATLATLAAGMAGSTGILLIVCFIQLGSSNNQVDTKNHSGMEKYTGEYYRKYDIQEYPQGLKNYTEVYELDKEREMPKLIIKKIGKHKKKWKKTEEKEKYIMMKKKKISKNKMKRKKPPTKFVKTVSDKNKDSNMSGSKEVADDMGRKPDIVNSAIEQRNPTVLKPTTYFTEMMSLYPQIPTKNVSYFEKSENLLRMPKKYYEDRKRKRKTIKKLPKRTVQKIIKKSKTKYRRNFNLATMQPTQVSNLIDKSFSVLNNEVTTQMNLRKKSRKNLKLMRYPMPFQKLPFHYRYKRENDRDVYILKDLDEIQFLSDEDGYDVVKAHVKNYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFW5</accession>
    <name>A0A0N1PFW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFW5"/>
    <dbReference type="STRING" id="76193.A0A0N1PFW5"/>
    <dbReference type="InParanoid" id="A0A0N1PFW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="26920" checksum="F1846FB6DD1B00B8" modified="2015-12-09" version="1">MSGKSFSNKVVFISGASSGIGAATAIEFTKEGANVVINGRNETKLKNVYKQCEAFGKKPLIIKADISKDEEAKAAIDETIKTFGKLDVLVNNAGFSRSGSILDGNLIASYDEIMATNVRGAMHLTALAAPHLIKTKGNIINISSVAGTAVPLLPQFISYCVSKAALDHFTRCSALELSKHGIRVNTVSPGPVTTDFQINAGIKDIMVDRTIPTALNRVSESIEIADVILFLASDKAKAITGSNYVSDNGFLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGV4</accession>
    <name>A0A0N1PGV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461107">
        <property type="protein sequence ID" value="KPJ09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGV4"/>
    <dbReference type="InParanoid" id="A0A0N1PGV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="162" mass="18847" checksum="F5F263D603EBE26E" modified="2015-12-09" version="1">MNDLSFGLKMTVLKDLPTNMNKRRVGLEFMRNKMEDALGRSAPTSFAENEIKLKLFRMMHESISDSESKIKRAEMIRKTYENNTSFEIGFIVADTTDKYTTMVDVGGMLDRLFDEWRPIEHINAYEHIANKGIEISQLIELVKTVVKKNRTSSYRRFLNISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGV9</accession>
    <name>A0A0N1PGV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGV9"/>
    <dbReference type="KEGG" id="pmac:106709765"/>
    <dbReference type="InParanoid" id="A0A0N1PGV9"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="23151" checksum="024882C5ECB5F7A5" modified="2015-12-09" version="1">MIKTQPWIGGTEEEYETKHFGFGAQSLKIAVRQMVEHKIKSGVKDMESYLQDKLDLNDTDKLTLTHSCDKLVKLYCERAGPSLEAIDSEIERLLKIPPNVLLPEDEVQLEQVSDEEYQKLKEEVALLRKRVERGASLEALLSAEDEELSSIENVCEIARKDMEILDLLQKSCIKSDVKLIKNATEFICSMVPFLKKSDSIFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGX4</accession>
    <name>A0A0N1PGX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myb protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460427">
        <property type="protein sequence ID" value="KPJ14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGX4"/>
    <dbReference type="FunCoup" id="A0A0N1PGX4">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGX4"/>
    <dbReference type="InParanoid" id="A0A0N1PGX4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HTH_MYB"/>
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        <location>
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            <end position="39"/>
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        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="427" mass="47527" checksum="5642A777C60E59A2" modified="2015-12-09" version="1">MKTGYLPSAQQLGNQWAKIAKLLPGRTDNAIKNHWNSTMRRKYEPDILDSFENIRRKQARSWTDPFNESIQSNTSSNAPSKQVQHFRQLLKEQLSSLQKTHNSPDRGNLVAVDTVEIVESPFKYVNIGSLPDSPIKNFLSQTTTTDNQPMNNVTTTSYALQAESNKEIVVPSVYISPKKSMESSSPPPILRRAKGKKPLPAHISNEWSASPLLQTPTPANITPGGTQLRNMTPKTPTPFKLAMAELGKKSGLKYEPSSPGLLVEDITEMIQREENSDTTVHLNDSILSATEEAQALAGDSSVLFSPPSIVKNSLQEESTSLHSLLSSENTPENVKYEEMDIESVITEKTKVRRVSDEPIVVKKSAVRSIKFDQAPAETATDEKPMLLLNDNKWEIYACGKTQDQLDLTVLAHQYLRSTALKPRSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHH2</accession>
    <name>A0A0N1PHH2_PAPMA</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="136"/>
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            <end position="223"/>
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        </location>
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        </location>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ19704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="414" mass="46555" checksum="85325123602A5CB5" modified="2015-12-09" version="1">MTSKSEKDRAKQIQDRCQNILIQMLKDEDNKYCVDCDAKGPRWASWNLGIFLCIRCAGIHRNLGVHISKVKSVNLDSWTPEQVVSLQQMGNSRARAVYEANLPDSFRRPQSDSSLEGFIRAKYEQKKYIAKEWVPPTLPKVNWDKEIDEELERQKRKKKSTTSTLGPLPAPTVGDKKYNKSDVIPSLPKPKSSVSPKLGRSTPTSSQTDTTKSSNGSADLLGLDTGKIETKTSTNDDIFSSFFSAPQEKPAEVPKPETKSDLKAEEENFFKQAAPTEKEKSKLTKDSILALYSQTPNTNLVNQFSSVPPGQPQAFPFAPTYQTPMYNSMPMQNGMQQFNQFQPINNQFQQFNSQIPPQMQTNPPFPQNNQFFSNQPIQQPQQLTQQFGSLNLGQSFPTAFGQPNTNVASNTSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHI9</accession>
    <name>A0A0N1PHI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative metabolite transport protein CsbC</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">RR48_04718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N1PHI9"/>
    <dbReference type="InParanoid" id="A0A0N1PHI9"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="611" mass="66896" checksum="5E07BF1A9E30EF84" modified="2015-12-09" version="1">MNVVLAVCGLYDIMGERNSENFVKDRPRPRPTARSVQYHDHTDDKRKQFHNLSCFTHGCSTGWVSGVLGSEALAGGAWLAALPCLVALPAAPFFAVLADSRGRKAGAFCISLSFIISWSLAAWCGPRGVWTARVAAGAGGAGAMALAPLYCAEIAPRTRGLAAMPALACSCGILFAYCAGVLLSPHALSLSMAVAPAVLLLSLLWLPETPLYLINAGKIQEAARVMCWFDGSDFREDLTDVIEQQEVRIRTSECAGRRQHLRRQDSDTFQPMLKRSSGLDSNCDKKEQISPCRELLTRRRSRRALASCCVLVCLAAGSGAGAVSSFAAALLRHSAHKLPSLNLTAYNFTIYNGSLPRDAWGAWDAGCVLCGLALVLGAALATLTVDKLGRKTLLLWSCSGIACCLAILGVYCDPHLRMHSWYQQPLYKKIIKEKTREIERIDRESFRDLYNESITTNVSGVPIGLFRISLENVTPTSWSVKYEQSEGESEDIWAPITLLSMVLFLYNIGLGSVPYVLISELFSVNVRSLASSFLISCTWLSNFLLLRYFGSLASYLGLHAVYYLCASSTLLGTAGLYVLLPETKGKSQGQIEEELNQPILNWRKRKQRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHR2</accession>
    <name>A0A0N1PHR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM102A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHR2"/>
    <dbReference type="STRING" id="76193.A0A0N1PHR2"/>
    <dbReference type="InParanoid" id="A0A0N1PHR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="592" mass="64490" checksum="9DB6539AEB328F1C" modified="2015-12-09" version="1">MRLCVRYREEVCNHSVRWNAQFSFVCKMCANANTGVLEPALLRVSVRKECKGGRSYQKLGFCDVNLAELAGAGEATRHCLLEGYDPRRRQDNSVLRLRIKMNMISGDPLFKVPERKQEAAEGGDSGAESAAPPDDDCACSTNSSGFGSLTGAKPHVPVSEGVTPPTIAALAACEPPPEQEDPPAPDHAAVSGGVAPCASCQQHTHSRNSSNTSGDMSSKASGYGSSVSAASAHSRQSSEGECAPDSRDTRHHNSVCVERTCTTSTSCTSSSTLHVPAPSGRHSGRALAKLLLEKTLVSETSDLYLTPNTTLTGPPDVIPRHALHSASPASEEYRTPDSTLLEENTFAMPTYFDHKRKAAAVVSAAVEPLANFHIFKQKSLNTIPALLERNKKNEELFTNFPFLTPLAHRKNSLVSNANRLSGCIEDEFYCIPSDPEGDAELVDRIDVRHRFRSLSNQALDDDVHTSTPKNDSNAEVLQRNSFASQRGRKVEVLRHSYTDYTRNPSSGSLTASASESGSLERARAARDRRQRAPPHPPPHTPRTPRTPRPLTTCSTRVASERMVVSSDWSSPTSDLAPVSRPRRTRKYFIDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIF6</accession>
    <name>A0A0N1PIF6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047215">
        <property type="protein sequence ID" value="KPJ21443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIF6"/>
    <dbReference type="STRING" id="76193.A0A0N1PIF6"/>
    <dbReference type="InParanoid" id="A0A0N1PIF6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11379" checksum="736B1150B3BAF0A0" modified="2015-12-09" version="1" fragment="single">PHAFTLLAILNHTRHQVRELYQLGNNDAAMAYSCVLSDLAKLLILLNKQQVPVVPDEWPRLASWAERKERVDKVGSRRIIKPTNVASIFVMKAKAHAKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKQ0</accession>
    <name>A0A194QKQ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative muscarinic acetylcholine receptor gar-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKQ0"/>
    <dbReference type="FunCoup" id="A0A194QKQ0">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QKQ0"/>
    <dbReference type="InParanoid" id="A0A194QKQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="105"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="798" mass="87125" checksum="B79B04F1EAE8994C" modified="2016-10-05" version="1">MNGTEATDVNRSTPIYAIGTSFITQWKLQKFKERTCVSSSSYPECQGYLISNSTNDTDVYYYNTTIDTGLSGDGTLEPVLPPFPLWMAVIFATCLVLVILLTVSGNVLVLLAFLVDRTIRQPSNYFIASLAATDLLIGTLSLPFYTDYVLKGYWHLGPLLCDLWLSVDYTVCLVSQYTVLLITVDRFCSVKIAARYRAWRTKNRVIWMVTVTWIIPALLFFTTIFGWEHFVGYRDLQEGIFKTAYDMQKKSEAKQRKMQSMVALSAGVMSGMAGRAAGMAGLPKPTISSEDQVKVSESEQKDATTKGSLAAPLLNLGGSSDSNSSQKSSAHKSSATATGTSTTAESEGDKKEEQVEAERSSSPAFDSDDESTTQCNVKKRPSVANLVMQTGAMHLLNNMRLNGGMLLNTDVKQSPVLKHDIDKPKTSLSQISEKSLLDTENADTFKSNRHISAPVTTSSASVISPDSSGLATPSEREVSSTIAQRIIPPPSDFRCSPTVSESPPSHSESSRTRIIKLIRGDGSSYDVLVGMDGADLRYMDESSVNVPSPTNESPPSSITFPTATEPSSPPIISGNVTNTSLLQAALIRATAEAQVTQPKTNVCPSPPIKVNTEVSLTTGERPKPVITLVSSSSNNNENMPPKEVENKTAPTRLTPGVSMAIESSELSSPAVSGTGRSDSKKEFVKNIGKKLKSKRSKRDGLFPSIGRQKSKSENRARKAFRTISFILGAFVVCWTPYHILALVEGFCTDPPCINKHIYMFSYFLCYANSPINPFCYALANQQFKKTFTRLLRGDFHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL58</accession>
    <name>A0A194QL58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ecdysone-induced protein 75B, isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL58"/>
    <dbReference type="STRING" id="76193.A0A194QL58"/>
    <dbReference type="InParanoid" id="A0A194QL58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11469" checksum="83E537D151900EAD" modified="2016-10-05" version="1">MACGAELRERHSVLVSMLEARRESSDSGCSSDESSDPERETNCSCDSQGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM10</accession>
    <name>A0A194QM10_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM10"/>
    <dbReference type="STRING" id="76193.A0A194QM10"/>
    <dbReference type="KEGG" id="pmac:106719799"/>
    <dbReference type="InParanoid" id="A0A194QM10"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF68">
        <property type="entry name" value="GH19763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="56097" checksum="72FAAE651AA4A69D" modified="2016-10-05" version="1">MQACYPKKYPKTHWDTLNVVYPVRVLDQKDVSSESIARKWRPEPEVIQQNTKTDRDIQEHRDYNPYNECMRSQTSLDYGFKIPEIKRFNKHTPCVENEYIYPLSRRIEDRPPACNVHGTTEMKESFSTPQSFSRLITDKDQFKHPVSLESNPIPIAPSWHKELEPIDTTYEGFEKYLDPYLTTSRLHHRPYTADQLKKISNSKDIVTYYTLSDIPWVWSTKPTHNDWFLRVKCPKTMYDREKFKGDFREIRTHNKLHWVPGSFRTEAKDNYGFNTHQKDIKMEKHEEHLLTVYYESKCPDSKKFVLDQLQPAIELLHRYVKLRLIPFGKSRSINYGDDGFECQHGPEECLGNMVQECALRHMRGHSDVQRVTYVVCEMASESGARGSLACVKHAGLSVSDVERCVLAGEGVALQLDSEYHTDKLKPKFIPTVTIDGVFSQDFQDAAMTDLIGTLCATLREAAPCARYYNNRAWEYIFYNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMJ5</accession>
    <name>A0A194QMJ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10-like A, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="COQ10_START"/>
    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="24749" checksum="18F6C71FD4A03122" modified="2016-10-05" version="1">MTSIRFFSSRSFQGHHINRNEGNKSSIHCQCQVTGQQSRNLFNFSKPSRKREYSGRQLVGYSMDQMFEVVSDVENYYKFVPWCKQSVVLMRGPGHLKADLIVGFPPINESYTSHVTLVKPYLVRAECMDGRLFNHMLTLWRFSPGLKREQQSCVVDFQISFEFRSALHSQLSNLFFDQVARQMEGAFIREAGKRHGPATMQPKNLLLNNQTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMY6</accession>
    <name>A0A194QMY6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein dachsous</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMY6"/>
    <dbReference type="KEGG" id="pmac:106719384"/>
    <dbReference type="InParanoid" id="A0A194QMY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Dachsous cadherin-related 1b"/>
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    </dbReference>
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        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protocadherin alpha 2"/>
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        <property type="entry name" value="Cadherin-like_dom"/>
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    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264490" evidence="11">
        <location>
            <begin position="20"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="112"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="224"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="343"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="442"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="583" mass="63916" checksum="5934AF1B8BE93F27" modified="2016-10-05" version="1">MLRVITLLVVAAAAEHVREFTVRENARAGTLVGHLGDELPDAAPPYTIVPVPGSAVNDDLKIDPHTGEIRTRAPLDRENRDQYALVAIPASGDNIRVVVRVSDENDNAPTFPTPVMNVEFSENTPRDVKRKLNPARDQDLGVFNTQRYNIVSGNTENAYRLSSHRELDGVLYLDLQINGFLDRETTDHYELVIEALDGGTPPLRGTMTVNITILDVNDNPPVFAESVYSATIPENATIGTTVLKVFATDSDAAENGLIEYSINRRQSDKENMFKIDPDTGEITVNKALDFETKELHELVVVARDKGAQPLETTAFVSIRVTDVNDNQPTIDVIFLSDDATPKISESAQLDEFVARISVHDPDSKTEYANVNVTLSGGDGHFDLRTHDNIIYLVVVALPLDRESRSTYTLNVVATDKGSPPLHASRIISLRVTDVNDNPPVFLESVYKTSVPEAAAPGTPVIQVSALDADEAENSEIRYSLLPTPQSDWFAIDERSGLVTTRSRVDCETNPMPKLTVVATDRGTPPLSSTATLLVTVLDVNDNEPIFDQSFYNVTVSESEAVGSCILKARRIALGPYLEEDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPJ3</accession>
    <name>A0A194QPJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBX domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPJ3"/>
    <dbReference type="FunCoup" id="A0A194QPJ3">
        <property type="interactions" value="1773"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPJ3"/>
    <dbReference type="KEGG" id="pmac:106719449"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14302">
        <property type="entry name" value="UBA_UBXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000044">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041923">
        <property type="entry name" value="UBA_UBXN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="35977" checksum="2EF3EF56780D11FF" modified="2016-10-05" version="1">MAEIQTLMEMGFPKERAEKALAVTNYKGVEPAMEWLLAHADEPDLGSGQTIGGSSSTDVAATPSASSEPASEPASEDSAVAKSFKCDECGKLFKNQDEMEFHAAKTNHSSFSESTEEKKPLTEEEKKAQLALLEERMKQKRKEREEKEKAEALERERLRIKSGKDLQDAKLRLQEQEMQKLVEQRRREKIEDQKARERVRAQIEADKQARKLAASGQKEVPAPAPIPPQPAPAAPKVSYEQARIQLRLPDGQSLSHTFGAKEQLAAVRLYLQMNSQEFAQQENFKLMTTFPKKIFSVDDYEKPLELLGLVPSAVIIVSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ36</accession>
    <name>A0A194QQ36_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lysosomal alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_08487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ36"/>
    <dbReference type="STRING" id="76193.A0A194QQ36"/>
    <dbReference type="InParanoid" id="A0A194QQ36"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1089" mass="125271" checksum="DB3B1C9805EFE024" modified="2016-10-05" version="1">MPKPNKNEKSRELDDDYEVVSFEEFCDKPSNAKTDLLSLNDNINYRIYYESLKLPKDGSSSNIEEAFDREIEGQKETSLNGPKGGVYTKYQRFSQRRTTLQRAWEQLKNICPGMLGVGLMCVLCVAVWLVVGGTLGGAWTEDKYRKLWQRVHPENTERPMTYYEMVVPEVHYHDHNNLSTKNKFNGSEGSRKTPLDDEKYQRLMRPKPIQVPTEAPETAKYLKRTPEMLRNMCSNVTDNMRFDCYPQTGANEEACLKRGCCWKSTSIQGAPYCFYPPNYDTYKFYNMTENKRGVTAYYALNRPSGYPGDFRMVRVDIMFVTGDIINAKISDAENPRFEAQYPEIPMVYGSIKTMKYKMVLESSSIGFKVVRLSDNVTVFNTQNIGGLILSDKFLQISSLLPTNQIYGLGERRARFRTVLNEWKTFTMFNSDQAPVENTNLYGTQPFYLALEPDGKAHGTLLLNSHAIDVVLQPTPAITYRTIGGLFNFYMFLGPSPGDVVSQLTEIIGKPFMPPYWALGFHLCKYNYGSLQVTRDVWKSNRDAGIPLDVQWNDLDYMKNGNDFTYDDVKFKGLPEFVKELHEAGMHYMVLFDPGVSAAEKAGTYPPFDKGLEMNVFIKNSTGQPFVGKVWNKVSTVWPDFTHPNATMYWTQMMSNFHKKIPYDGAWIDMNEPSNFVSGSLYGECAPEELPYTPHYLTNGLKHKTLCMDAHHYAGDHYNWHNLYGLTEAIATHFALVEIRGSRPFIISRASFPGLGRYAGHWSGDVDSSWHDLRMSIPELLSFSLFGIPMMGADICGFRGNTTVELCKRWMQLGAFYPFSRNHNSDSSIPQDPVSLGAEVVSSSRTALRMRYSLLPYYYTLFWRAHLHGELVARPLYFEAYFPAGYWYSLDGTLLTSGWRNVTEQHMLAVKNDTMMCDIRVVASCLYKSRQRAWCQRVSVARALYMCWPHLTAAQARAILYWDDGLGLQTYDESKYSLVHFILDKQEFRSELQWWAYGMPTVNKITIFGQKVPIKNVTINQKPCKKPNCEFSYSSNSKIFVIFNINLRLNEPIHIQWMLQEKLKLTELYLIKALTIYIYNNHHQLTIHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQF8</accession>
    <name>A0A194QQF8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQF8"/>
    <dbReference type="FunCoup" id="A0A194QQF8">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQF8"/>
    <dbReference type="KEGG" id="pmac:106718685"/>
    <dbReference type="InParanoid" id="A0A194QQF8"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="27807" checksum="16B8044E9DD44A2A" modified="2016-10-05" version="1">MEVQNINVDDFLPAKKTVKLKNVKRRAVSESGDGMEVEEHNGIQGKPKLSKPKAKRVKKNAEPNESKVNMRKVPVPAHRYTPLKENWLKIFTPIVEHLLLQVRFNTKTRNVEIRVGPETKDIANLQKAADFVKAFIYGFDVEDALALLRLDDLFVESFEVKDVKTLQGDHLGRAIGRLAGKAGRTKFTIENVTKTRIVLADSKIHILGSYQNIALARRAICNLIMGSPPSKVYGTLRNVANRVAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQL6</accession>
    <name>A0A194QQL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spectrin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQL6"/>
    <dbReference type="STRING" id="76193.A0A194QQL6"/>
    <dbReference type="InParanoid" id="A0A194QQL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="26943" checksum="357E26E493F9DEFA" modified="2016-10-05" version="1">MSVCPKTIFTGGAALEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDALKEFSMMFKHFDKDRSGRLNHHEFKSCLRALGYDLPMVEEGQPDPEFEAILSPLHRFPKWQYSHEERFNSWKAVLSSETQGNGNAYIYNNVRICYKHFENYYQLPSHQLTRNAVPTLNLDLPENLQRQPIFTTTATPPTKNPMDSFAHPSTSSTYHSRQAISGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQP2</accession>
    <name>A0A194QQP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQP2"/>
    <dbReference type="FunCoup" id="A0A194QQP2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQP2"/>
    <dbReference type="InParanoid" id="A0A194QQP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="44510" checksum="37AECF3E880B5016" modified="2016-10-05" version="1">MTNVFTMGQGLQREKSSSLVSERQREALVKGAPESHTERGRGQDDARGPGAEACAEAEAVAPTHEDLVTRAEGVLRRLLLTDNYDSVSNFISLYDAFEKSAEPLQQLFGKYTPPIRPRQHTCVGLGIELLRRWRSLDKRRPGFAAACALVSCEEAVEDVREYVTSGEGPEAVLAAEKEHVMVCVQIVVDGRAGVLLADPGYHVPRVVTVMADRGYPHTGWFTQSEEAHCRKEYSYAFCPLNNGYVEWRERETRGSNFKCQTSLVYVARPYLDGVNVTERRNLVYNFRSLLARDQKGHLIAGLYFPVGGRGKDAQFTLFFDTGAEKHKTKYKFNNFIDPDAIPESISEEVEICNAQMNYKKGELRNIICRLAEVLEDHSFIEQLLEINDDICRMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR58</accession>
    <name>A0A194QR58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Troponin C, isoform 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR58"/>
    <dbReference type="FunCoup" id="A0A194QR58">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR58"/>
    <dbReference type="InParanoid" id="A0A194QR58"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="16956" checksum="D7425EE587447778" modified="2016-10-05" version="1">MSMLNIEVLRKAFDGFDHNRSGSIPCDFVADILRMMGQPFNKKILEELIEEVDADKSGRLEFPEFVTLAAKFIVEEDAEAMQKELREAFRLYDKEGNGYIPTSSLREILRELDEQLTDEELDGLIQEIDTDGSGTVDFDEFMEMMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR64</accession>
    <name>A0A194QR64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane GTPase Marf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR64"/>
    <dbReference type="STRING" id="76193.A0A194QR64"/>
    <dbReference type="InParanoid" id="A0A194QR64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fzo/mitofusin HR2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15435" checksum="563215CCA225068E" modified="2016-10-05" version="1">MLQLLKTVGWRVVALTGAVYGALYLYERLTWTARAQERLFKRQYVAHAGHKLRLIVDLTSANCSHQVQQELSTMFARLCRLIDEATTEMDSELGEVRTAIAMLEDASAGAKRLRNKAHYLSHELELFDEAFLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRU5</accession>
    <name>A0A194QRU5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_14703</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 13"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRU5"/>
    <dbReference type="STRING" id="76193.A0A194QRU5"/>
    <dbReference type="InParanoid" id="A0A194QRU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ06261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="857" mass="97097" checksum="2A7B15ECCB97CA80" modified="2016-10-05" version="1">MSYTELEHGYQGLRQASQPQFYVENDGNLVPIRSPGELELCESPEAQCDGGKKVAVGVCAMAKKSQSKPMKEILTRLDEFEYIKMIVFPEEVILKKPVEEWPICDCLISFHSKGFPLDKAIQYEKLRKPYVINNLHMQYDIQDRRKVYAILEGEGIEIPRYAVLDRDSPDPKHHELVESEDHVEVNGVVFNKPFVEKPVSAEDHNIYIYYPTSAGGGSQRLFRKIGSRSSIYSPESRVRKTGSFIYEDFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVILSNQEKLISRKVCLAFKQTVCGFDLLRANGKSFVCDVNGFSFVKNSNKYYDDCAKILGNMILRELAPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCVVGVIRHGDRTPKQKMKVEVRHPRFFEIFEKYEGFKRGHVKLKRPKQLQEILDISRALLADIHTRHADPEIEEKQGKLEQLKSVLEMYGHFSGINRKVQMKYQPRGRPRGSSSDDGSGSAGGGGGGGEPSLVLILKWGGELTPAGRIQAEELGRMFRCMYPGGQGRHIPGEGSTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANTNGLLDNDCDSSKVQNMAKARLHEAMQVDREFTEEDRARINPCSSLSISAAMQLVSNPVRCCAHVHALIQRLVHIVLAKRDDPKTKDTILYHGETWELMGRRWGKIEKDFCTKNKSYDISKIPDIYDCIKYDLQHNQHTLQFDQAGELYIYAKYLADIVIPQEYGLTVQEKLTISQGICTPLLKKIRADLQRNIEESGEETVNRLNPRYDFEPWFLLLVKLILYAVFLKGKVNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSQ8</accession>
    <name>A0A194QSQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger protein 512B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSQ8"/>
    <dbReference type="STRING" id="76193.A0A194QSQ8"/>
    <dbReference type="KEGG" id="pmac:106719930"/>
    <dbReference type="InParanoid" id="A0A194QSQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="30797" checksum="DA4FC771A5F74398" modified="2016-10-05" version="1">MSILLSSSNAGILHGGHSGLAVPPPPPHISASSFSPSSFPSGSLPSATFSGNGFHSGGLAVESHGTGYDASGDAGPILAAATLPGAGINGPVGAPLTAPSGAGLGTPLGSFGASLSGPGGPLGGPLNLGGGAPPPGPKAPVINEIHGLANSNGAPTQYRVRDETYQVVRDVTHRVPQPVPVPVPQQVQIPVPQPYPVQVPVVRNVPVPVVKIQHVNVDKPVPYPVEKIVKVPVERVVKVPVDHPVPIEKIVEVPIVKVVEVPVHVVKTYPVPVVKTVHHKAHISHGHGHGHGYGHGHGWSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT06</accession>
    <name>A0A194QT06_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_11718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QT06">
        <property type="interactions" value="1425"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT06"/>
    <dbReference type="InParanoid" id="A0A194QT06"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000006">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="17"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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            <begin position="552"/>
            <end position="603"/>
        </location>
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            <begin position="1643"/>
            <end position="1716"/>
        </location>
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            <begin position="2300"/>
            <end position="2487"/>
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            <begin position="2507"/>
            <end position="2558"/>
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    <feature type="repeat" description="RCC1" evidence="11">
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            <end position="2612"/>
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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    <feature type="repeat" description="RCC1" evidence="11">
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            <end position="1332"/>
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        <location>
            <begin position="2996"/>
            <end position="3012"/>
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            <begin position="4104"/>
            <end position="4114"/>
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        <location>
            <position position="4043"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ06671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="4127" mass="448763" checksum="AAEAC2FC8E891815" modified="2016-10-05" version="1">[encoded data, 4127 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT94</accession>
    <name>A0A194QT94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine-rich with EGF-like domain protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:animal organ development"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
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        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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    </dbReference>
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        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="176"/>
        </location>
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            <begin position="166"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="37573" checksum="170A031F0279E80E" modified="2016-10-05" version="1">MQIHVDYCNRLKARTNLGRGEIDDCNRCKVLSDSFKNWLQKTARGKYEGGDTAWEEAKLKSYSRSEMRLVEIQEGLCSEVKKHKDRCYGLAEEVEHLLEQWWVHEDPNSQDLFTWLCVSTLQYCCPQNHYGPLCTACPVDENNKICGEKGSCDGDGTRKGNGSCICNRGFAGEFCENCAENYYSTPEADCKPCHKACNNCKGEGAAACVICQTGWELEVDVCTDVNECLKENLCKVNEYCINWEGSYSCKTCDVTCKTCSGKGITNCTSCEVDEILVNGMCLDETLKHQYLLSTMKRLALYALLLLVASEGSYEIVNIKCAKQSSDFSGKKLGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUG4</accession>
    <name>A0A194QUG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUG4"/>
    <dbReference type="FunCoup" id="A0A194QUG4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUG4"/>
    <dbReference type="InParanoid" id="A0A194QUG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="591" mass="64259" checksum="C3CEF05D2260C3CA" modified="2016-10-05" version="1">MKSKPAHYADPPFRPWPPLSRQAQPNFYFRPPDPIDVRNYKTSSSKGSTYSDFSGVSAYSNKSRDYYFLSPSYRSAGAPTPGSYADSYINRDRPRQLRHPNPASPAACPCSRSRSLEDVRTEIVTEWEDDDENGNRIVAPATKFNRSPYKVNTTFQKQGFLTRHSMENLVDKSPQVPPPKRISALQRSAPIKGKAKILINRHVSERVAVKLRQSRSAPLNRSAPSCACAVTDTTTRNGGHQNAPISPSGAASVGLGADVNGSRPTFKPVTVLEDLQAVRCAEFHPNGKLYAVGSNTKTLRICTYPKIDDIKDISAPTAPTVLLKRTKHHKGSIYCLAWSPAGDLLATGSNDKTVKLMRFNSHTCNLEGQEVELTMHDGTVRDVCFIEDTSNKTSLLVSGGAGDCKIYVTDCATGKTFQALSGHSGHVLSLYNWGGAMFVSGSQDKSVRFWDLRTGGCVNIISPPTGHANKGSAVASLAVDPSGRLLVCGHDDGSCALHDVRGSRALQRFTPHSGDVRSVRLSPGAYYLLTAGYDGRVVLTDLQGDLTCAMPSVPVARHPDKVISARWHPDDFSFLSTSADRTAVLWTIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUH5</accession>
    <name>A0A194QUH5_PAPMA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUH5"/>
    <dbReference type="InParanoid" id="A0A194QUH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="35" mass="4043" checksum="814F648464D559E4" modified="2016-10-05" version="1">MSTFLSCLETERDLLVDYWTSVEGQELLRADHANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUH7</accession>
    <name>A0A194QUH7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUH7"/>
    <dbReference type="InParanoid" id="A0A194QUH7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="18739" checksum="B1B01922F5CB886F" modified="2016-10-05" version="1">MDSAESESVESSGCWLDGPGPSLFRFLLGIPISDNIKKNTDMFSPDALEAILAGTLSDMELSSDDEEPFRFTSERELQSVRVGADVINQNQREVFPPDSDEDEGPSSSWIGTNDPGVTDTCEWFSKHATLHPDVELQEAQDLRVDSEDSPQPQAPVRFVLRAEELRSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUT8</accession>
    <name>A0A194QUT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Enkurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUT8"/>
    <dbReference type="FunCoup" id="A0A194QUT8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUT8"/>
    <dbReference type="KEGG" id="pmac:106717195"/>
    <dbReference type="InParanoid" id="A0A194QUT8"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF0">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="253" mass="29700" checksum="3A3C31FB2CCA49DC" modified="2016-10-05" version="1">MSLVEITHHDEVIYRILDKPPPEPPKTPRYESKLEKELKATKIPQRRRTFGYAETPMKPPEQFLKKGEGIGQPTKKSDHKCIMGNLPAVPKCPPPEKAKEKPKVNIKVRNIKAVLKAKPRPVEPRLVDTRDGHIKKIKGSGEVPEYCLRPDFGQMPKYLVKRNRKIQRRLEKIRLNEENKESLCKLINEQERQKLLDDLKQNWQLMQKAFLQLPMLTDTIPKIIRKTKMEQELRQLEKDIALVESNPYIYIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVG5</accession>
    <name>A0A194QVG5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_15455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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    </dbReference>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub2"/>
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    </dbReference>
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        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09314.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
    <sequence length="228" mass="25554" checksum="09BF6E812041670E" modified="2016-10-05" version="1">MNILEEEQRNAITYAHERLLKLAAIRGPAQIAKQIADKGATGSLAVPTLINLECARWQALCTGAPFPWAAATRAIAGELRQTNAAQTLAYTAGYRAATQRCRVQIGLPITGKYRDPESDQYYNNNDGAKIILASHFDLEYVLGHKIAFLCIAKGSPRPHITWFKDGVEIFAHHYLHIHEWPIEEDRVKSKIEIDPATQMDAGVYECTADNMYSIDRRSFKTDFSIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY9</accession>
    <name>A0A194QVY9_PAPMA</name>
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        <submittedName>
            <fullName evidence="1">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial</fullName>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Glossata</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="pmac:106718745"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="KPJ07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="19302" checksum="DF963D4C9E59E2FA" modified="2016-10-05" version="1">MEAIKCRNLDHEVNGKAMTAAYLTEVERQYKTKYLRDISTHAELLVYDWTGGGEVEVVVEDIERLNFDKYTEREEPKMKDWRLPREVEWADQRMLYTNKKDYLMNLLAIPRLDVPELITSADDAYEREKVIYGHPDFQHLDGYNKKDGALLTKTKMPKYSEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWI6</accession>
    <name>A0A194QWI6_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Putative odorant-binding protein A10</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">RR48_13303</name>
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    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053240">
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    </dbReference>
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        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
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        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264697" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="120" mass="13896" checksum="38F349009AE0636E" modified="2016-10-05" version="1">MKLFVVVLCVAALAFAEDKYEEIEDNFNLQELLENDRLLTGYIKCLLNKGPCTPEVKKIKDKLPEALETNCAKCSDKQKQMGKVLVKQVKKAHPELWDELKNLYDPQGKYQKEFQQFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX98</accession>
    <name>A0A194QX98_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">RR48_12935</name>
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    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="92"/>
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    <dbReference type="STRING" id="76193.A0A194QX98"/>
    <dbReference type="KEGG" id="pmac:106718211"/>
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    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="529" mass="58567" checksum="6ECD9118244D958F" modified="2016-10-05" version="1">MEDMNVVQAHNLLGQKTQIPTKRKDNALTKALRSCCVIPQRYILGVMGLLGVCNAYTMRVCLNLAITQMVNHTKSAGSHFDPDACPDDVVVGNATAVLRPYATFEWDEKTQGLILSGFYYGYAATQVPGGYLAERFGGKWTLGVGLLSTALFTFLTPIVIRAGGATWLFILRVLQGMGEGPTMPALMIMLARWVPPHERSFQGALVFGGAQIGNIFGSFMSGILLADGKDWAYVFYFFGGFGIFWFTLWSLLCYSTPNTHPYISKKELNYLNKNVTTAENKTAKDPVPWKAILRSAPVWALVWAAVGHDWGYYTMVTDLPKYSHDVLKFNIATTGTLTALPYIAMWISSFLFGFICDLFIKKGWHTIKTGRIIHTTVAATGPAICIILASYLGCDRTAAMVYFILSMALMGGFYSGMKVNALDLAPNYAGTLTSLVNTTSTFAGIVTPYLIGLLTPDSTLVQWRTAFWVCFVVLVGTNVVYCIWADGQQQWWDDVRQYGYPEGWKHGPLIREENPEQPESVKLTSRNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXG1</accession>
    <name>A0A194QXG1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXG1"/>
    <dbReference type="FunCoup" id="A0A194QXG1">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXG1"/>
    <dbReference type="KEGG" id="pmac:106716798"/>
    <dbReference type="InParanoid" id="A0A194QXG1"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000035">
        <property type="entry name" value="28S ribosomal protein S9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="401" mass="46628" checksum="350DD897043521D0" modified="2016-10-05" version="1">MSHVIKTSLKQITPITRYFYSCGKNPNLHNIRFYSNKVTTAHDDIYKNFTDWETLNKKKKISKPMRAYLERAKEHDEFMKKQQFEYNIGKRHLANMMGEDPETFTQKDVDRAIEYLFPSGIYDPAARPLMKPPEEVFPARKAAEFDEAGRPHHFLFYTGKPNFFKLLYDAAENIQLLQQFEDKVIRKKATPDPNGKLDLNATLWLTKDQLEQLLVEKLNDLEYDNFKLVMERLASLPYSYRIKDFIEKYRKSLSSQKFALEIPKPSYDDQGRAFVTTYECLRKKARGNVTIHSPGTGLITINGKDLTYFEDTQSREQVIFPLIFTGLEHKVDVECNIEGGGPSGQAGAIRWGIAWGLRSFVDKSMLEAMQVAGLLTRDHRRRERKKPGQPGARKKPTWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYB4</accession>
    <name>A0A194QYB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotrimin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYB4"/>
    <dbReference type="STRING" id="76193.A0A194QYB4"/>
    <dbReference type="KEGG" id="pmac:106715680"/>
    <dbReference type="InParanoid" id="A0A194QYB4"/>
    <dbReference type="OMA" id="HGGQAHQ"/>
    <dbReference type="OrthoDB" id="6365338at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264723" evidence="2">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="317" mass="34403" checksum="5A72323A946D3831" modified="2016-10-05" version="1">MAGKLCGDVLGVLLALVICVTRPEHVSSAQRELGKGVSGNASATSPPGSDNAIRAGPAGDGPRPTPRTGPYFDLAMSKNVTALLGKTAYLNCRVKNLGNKTLNMQVSWVRHRDIHLLTVGRYTYTSDQRFRAIHLPHSEDWTLQIKYPQHRDSGIYECQISTTPHMSHFIHLNVVEPTTEIIGGPDLYIDRGSTINLTCVVLYSPEPPAYIFWNHNDAIISYDSPRGGVSVVTEKGETTTSFLLIQQARPSDSGTYQCNPSNAQSKSVMVHVLNEANSIFPLSGEYPAAMQRGGQAFAPTSPAHCFVLAVSLLISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ82</accession>
    <name>A0A194QZ82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chondroitin sulfate proteoglycan 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QZ82">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ82"/>
    <dbReference type="InParanoid" id="A0A194QZ82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013040220" evidence="7">
        <location>
            <begin position="16"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="2200"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="199"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="427"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="569"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="684"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="923"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1495"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1602"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1833"/>
            <end position="1931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2267" mass="254147" checksum="C999F28A3E891628" modified="2016-10-05" version="1">MELLLVVSLFSLVLAYDKASFYGASYIAYPLQEAKGATDISFKFRTHLSDALLLLAAGKTDYCMIRLESGRLKLHINLGAGESELSSSKGIHLNDTQWHHVSIIRREANLTMKIDESTVKKRLPGRFFELNIHFGIFLGGQGDFSELFLGHMENFRGCIEDVYYNGVKIIEKARSRSGSVHVEGVTWNCAPEFDADINSDISFVDEGAYLILPRINSRAGGRWQIEFKTTTPNAIILYNYGGGRGSDFLAVEILEGVVRVKMAKGQIVHTVRVNDGQWHKIHLLFNPSLIELSVDNIAMSTRIESGGMRYLDLSDSFYLGGIESEKRQRAFAKGIKAADSSIMGCIKPIEVDDKLYGLPNAVVTYGVSPKCVWWYPCHANPANPPCLPNAVCEQHGLDHFTCKCDSELCINPDYAEKYKVFSKSSSELELVSLYPLTVQEGGVAVITTQNIDVVLDHHKYGVRPSGVVLHVAQSPMHGRIAVDLSLQRNLPQYANYIDGEGKSKQFFTLMDLSRDKVRYVHDGSENHQDAIVVEMELVPEARFTLPSYLQGRHAFALHVNVTPVNDAPVLNLPPGKVLRLTQGTRKVITSEILKAEDPDTAPEDLLYTVLHGKNEASSGHIEMSGQPVDSFTQHDIDAGVVSYVHGSSGDKQLNKTSLRLTLQVSDGIETSGPSVLRISIVPLQVRLVNNTGLQLVHNSYAIITAENLTFATNAEESNAQVRYDIVKPPQFGVVERLRVLDGTWQTVDSFTSEMINFGRVRYMHLLGNPSHDEFKFKASVGAIRTNILYDFRMTFIKLELYQSTNEELVLNNTREAFISPLHLRFQTRPIPLSADRILYTVLKPPKYGILHLSSGKHHLLMYGTFTQQDIDTDQLWYRLHRRAYSHIHDEFAFVVGANECENVTGVMTVRHTPSYLTSEHSQSRLHTTLERLQVMEGSRMAIPASHLDFRTDTVTNLLFNITHAPKHGKIEVINDNLKVIRDNTTYFTLQELNSDRVYYAHDDSESRHDSFHFMALSPEPEDFQYVGVFHIDIILKNDNSPVRANENIFHIVHGGARLITARDLSYTDADLDTRPSDIIYTVQRFTKDPPNGGIFRADNPSEQIAQFSQDDINKNLVLFKHQGKEYGKMAFWISDGLFDVNGNLEIQASPPFIRMYPTNGSIVENGKAVVITTRDMQVDTNMNCLEEDIRYEVTQEPKHGTMEVGEGVGASTFTQLDVAAGRVAYRHTEPSVPSDCFRFKVMCLDTFGEGSYPIKIFPSSYWEPLRVTTNKPLIVEESTSVNITKDILEVMHPQIEPSNILYQVTEGPYYGWLEITSTPGTVELENYNEEPVHTRVFDQSIINVNRLTYVQSGVNRTRDRIKMDVTNGIVWLRGVELTVIIIPEHFYVRSLNLTVVEGEAVSLKPGLFKTITEYYRGKVVSYKVIEKPKFGKIVMGDQDIGLLPVLKLNSGNIQYVNDGSEESSDAIRLVAITEGGKESEPFYLYVNISPVNDETPIVAANTGLCVWEGGTFTFTRNELYVNDIDTPLENVTIRVVDILSGYIALKHDLDTPRHSFTQADIDSGRVIFVHTNGTKGKMIFNVTDGLHELSKITFLISTKSVSLKLVRKHNLRVFPLMREPLNNYFLMAKCSDPTRTITYKVIRAPNLGRLIMLNGDNHHRTIKMFTQEDINNTLVYYEHTHPFSDLYTNDSFVFSIEAALAKSITDQTFNIDISVSSGGLAKYVNIPQTKVQEGDKVPIVVNVTNVISYLESQAGVRQPQVEGQWSQPAHGALNPSMSSLTQAQMETGVVSYEHDGSDTLQDKIDMSLYLLPDYVLLCNVTIPITIVPVNDQPFRLLTDTPQIQVVQGENYTITKNDLSTEDADTEPSGILYDIISGPTQGRIVMLDKNQSMDDAHSINKFSQEDINNGLVVYEHSGMLQTATFYFRVWDGQFKPTYTVFTIDVIPVILNATSLHPIYLQQGSNVATVTNEQIHVDTNAKKSKVWYNITRQPLHGMIYVGRSPVTYFSHKDLMDKVVIYMQNDMTVANDSFELIAYAHNTNSTLPFAIEVIVQPLMILGELKVDGEKAKLNLNIMDATELAKLTASDPVYTIIKKPRYGTVKKIIRSSGEKTSAREREVTYFTHEDVKAGVIYFVTKKKITDLNGYEDSFRFLLAASIFQPAAGDVKILIGSRSKKNLPGPNDPESHEGVLVNNGESMSYYMMIVMALSGVVLAIIVIAGLIKCRRYLARERNALVKIHGQGQGAVAPIPLPRPPEHLMPGHLDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZC2</accession>
    <name>A0A194QZC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OCIA domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZC2"/>
    <dbReference type="FunCoup" id="A0A194QZC2">
        <property type="interactions" value="1784"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZC2"/>
    <dbReference type="KEGG" id="pmac:106715907"/>
    <dbReference type="InParanoid" id="A0A194QZC2"/>
    <dbReference type="OrthoDB" id="6513616at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="26903" checksum="A5E0EAAB226DDA57" modified="2016-10-05" version="1">MNDPRSFGYENSNEQSTLRPAAPVPPGQYKFSPEELKVISECNNESFFKRSLPLGTILGLGTYAAVQNGNLKPNPRFGAFPKVTLAVVMGYFIGKLSYQQACAEKLMALPGSYIGQILRDRRDGRTGITAPPSNQSTSMLGASPSDIYSDAGPGNSLDLDIERPLFSDDTYRPYTDAPTNPAETAPPRPSLSYDDLRRKNRGEYTDARQDPYKVNPNSAPPVTRPRVPPPTPPATAPTNKYGDQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-07-24" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R037</accession>
    <name>A0A194R037_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R037"/>
    <dbReference type="STRING" id="76193.A0A194R037"/>
    <dbReference type="InParanoid" id="A0A194R037"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="186"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="44340" checksum="5CF8DA475E4B56DA" modified="2016-10-05" version="1">MNESTVQLLQEYMRIDTSHEENIESAVLFWKRQSNVLGLPFAVYRPAKKPICVITWTGSDPKLPSIILNSHIDVVTVAEQEWKHDPFSGYIDENGDLYGRGAQDTKALSITYLEAIRTLKEEGVKLQRTIHVLLMPDEETGGFSGMVPFVETEEFRALNPGFFFDEGMTSPDGKLYATYQDKRPWQLNITLHGESGHGSAVTDGSAMEKLQRLLDITREFRTQQKRIMSSKEPMDYGSYTTLNVNIIHGGVATNIIPSKVNLVIDMRLSMSAQVSDVNAMIQSWIEQVGNDTELSFIRKIEVSERTTLDGSNPYWVALVEAMREMDLKIEPIVCPATSDMVEVRNKGFPAIGFAYRPYTVSRIHAADEYINIATFQQGIQVYANILKRVANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0Q2</accession>
    <name>A0A194R0Q2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0Q2"/>
    <dbReference type="STRING" id="76193.A0A194R0Q2"/>
    <dbReference type="InParanoid" id="A0A194R0Q2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="27366" checksum="5EE10EBCAC7C381A" modified="2016-10-05" version="1">MSPKPKPNTRVSFFFKIPSEYSHATPSAERREHLYKILVIGELGTGKTSIIKRYVHQFFSQHYRATIGVDFALKVLNWDSNTIIRLQLWDIAGQERFGNMTRVYYKEAVGAFIVFDVSRVATFDAVVKWKNDLDTKVQLPDGTPIPCILLANKCDQQKEGIVNSSAKMEEYCREKGFAGWFETSAKENINIEEAARSLVNKILLNDKLLHNNDKDGERFALDHKIANGENSRSGGGGGKSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R141</accession>
    <name>A0A194R141_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0691 protein C9orf116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIERCE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R141"/>
    <dbReference type="FunCoup" id="A0A194R141">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R141"/>
    <dbReference type="KEGG" id="pmac:106714944"/>
    <dbReference type="InParanoid" id="A0A194R141"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF1">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13999" checksum="E1FE502A9BD9C871" modified="2016-10-05" version="1">MSSGGQLAITDKQEGGFCSATCIDKVCLQNEIKKPEIKTSDLYATCNLPKRFEHPHWFNGYGCQKSNQHPLYRTTSSEYGWYPPGVHSVTSVYYPAGQKFTNHLLASGMYRNYSLNTGMDPVGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1D8</accession>
    <name>A0A194R1D8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1D8"/>
    <dbReference type="KEGG" id="pmac:106716650"/>
    <dbReference type="InParanoid" id="A0A194R1D8"/>
    <dbReference type="OrthoDB" id="7380977at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="15053" checksum="B895CDF1AE4DEB99" modified="2016-10-05" version="1">MSTFIVGFICAIVLAVVLIAWLAYYMFCRERHKPEHYQYSIEDLRIRNIEIAQDQDEGVKKQVTAGIFLMPSRHHIDNDYISRPDYPESPAPQLQPKMEKLIEILNDGPVDADVNKNVSFDLSSQCHTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2B3</accession>
    <name>A0A194R2B3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_09865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2B3"/>
    <dbReference type="FunCoup" id="A0A194R2B3">
        <property type="interactions" value="2003"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2B3"/>
    <dbReference type="KEGG" id="pmac:106714233"/>
    <dbReference type="InParanoid" id="A0A194R2B3"/>
    <dbReference type="OMA" id="CHKKNCT"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="14">
        <location>
            <begin position="131"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="33130" checksum="9CA287D2AF451C0F" modified="2016-10-05" version="1">MSVEEDVMKIQKKLTKMTSEDGTGQEDALELLKNLQTMAINLDVLTKTRIGMTVNALRKSSKDEEVISLCKTLIKNWKKFLSTPNTPSKDSGSSSKPKKDSSKDKEKKEDREKDRKLPASFPPQSNTTDAVRLKCRELLTQALKIDGENPNSCGSPEELAEELEECIYTEFKNTDMRYKNRVRSRVANLKDPKNPTLRTNFLNGVISASRLAKMTPEEMASDEMKNLREKFIKEAIDDAQLATVQGTKTDMLKCGKCKKKNCTYNQLQTRSSDEPMTTFVLCNECGNRWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3L0</accession>
    <name>A0A194R3L0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Visual pigment-like receptor peropsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3L0"/>
    <dbReference type="InParanoid" id="A0A194R3L0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="35145" checksum="0B8E77A520A1ABF1" modified="2016-10-05" version="1">MCTGRVGRVLSVCKRRGTRSAPNAAALLPSLCYVIRMQALFDYQENGCPWYYFDSSYKMLLGACLIVFGVFGVLVNGWLFATFIHSHLLISKSHILVLNLCTASLGRNILGFPFSGSSAIEKRLHFRFYFTVVGVCWIKSAIFATPPLFGYGVYSCDSTGTICSFLWPALTSSTKELGYSVPYVILCGLVPLIAIFHFMGKAVRLEQIYYRNEQLKEEKRLTKSVHGTCIATLALWVPAGVLAGWQWVPLLIYGYRPHVPPALSLLAPIASEAATSIPVLCYLCGDERLRAALLGRMRKQYGLLRPDRAQRYMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R435</accession>
    <name>A0A194R435_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease 3'-5' domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R435"/>
    <dbReference type="FunCoup" id="A0A194R435">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R435"/>
    <dbReference type="KEGG" id="pmac:106713519"/>
    <dbReference type="InParanoid" id="A0A194R435"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="92"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="36354" checksum="90A664CC654EEABE" modified="2016-10-05" version="1">MDNLYMKGELLQIQTKNSEVIEGRFYSMTTDKSKISLYNVKELPQGEGDKGVCHYYDSEVRNITKIHEENEQIYLKLTQKECEEIIKTAKKYIYINQVDKNFHAAIDDLAQYNYIALSTDGANMGRKCKMPFIVLSTPQQIYIFDVQVMQYHAFDAGLKKLLECESPKKIVHDCRKISDCLYHKHNVKLNSVFDTQVGHLIVSRNKSGRIPRTVKTLAESLSTYLGIKNNTIEELDIVQCTERPLSTNIKENLAKNIAYLHRLSEMINDEMMLPFQRGVECYIENIRACDDFKAWELCGKSKQTPKDFKSAIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4D2</accession>
    <name>A0A194R4D2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General transcription factor IIH subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4D2"/>
    <dbReference type="FunCoup" id="A0A194R4D2">
        <property type="interactions" value="2154"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4D2"/>
    <dbReference type="InParanoid" id="A0A194R4D2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000115">
        <property type="entry name" value="General transcription factor IIH subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="608" mass="69091" checksum="756200E73CFAD80A" modified="2016-10-05" version="1">MTTSSEDVLLSVGYVRYKKGDGTLYVMNQRLAWMLENRDTVAVSHKYADIKTQKISPAGKPKVQLQVVLHDGTCSTFHFVNPAGADAQAKDRDQVKMLLQNLLPKFKRQIDGELEMKSRLLSLHPTLKHLYEDLVISKVLSSEEYWNTPTLKHYTDSSNVKQEAGVSGAFLADIQPQTDGCNGLKYNLTQDVIDAIFKTYPAVRKKHIDYVPNKMTEAEFWTKFFQSHYFHRDRIASSSSKDLFGECAKLDDQAIASAMKNTTLDLTVCKYLCLNEYGVSGAFLADIQPQTDGCNGLKYNLTQDVIDAIFKTYPAVRKKHIDYVPNKMTEAEFWTKFFQSHYFHRDRIASSSSKDLFGECAKLDDQAIASAMKNTTLDLTVDLPQFIEPVPLLPAEDEQPQDKDRGDSTSIHRNMIKRFNQHSIMVLKASHKTNSSNSNSSNSKTTNNNNKVVENGVRETNGVTEKRPGEEKCSTEPLEKKKRILEKIHYEDLEDSNTNGETQELKLSKVKSELHRLYLSCGEVLRELWRSFPQPGSGAGETEEAGARAHAFYEALLRFRNVKLRPFEEKMLRDLTPLATTLTKHLNQMIDTACAKYAVWQQRQAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4S9</accession>
    <name>A0A194R4S9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox protein unplugged</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4S9"/>
    <dbReference type="InParanoid" id="A0A194R4S9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000360">
        <property type="entry name" value="Gastrulation brain homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042982">
        <property type="entry name" value="GBX-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334">
        <property type="entry name" value="HOMEOBOX PROTEIN GBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN UNPLUGGED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="43134" checksum="8286F818125C5863" modified="2016-10-05" version="1">MESEVEKTQTKKKEPRPFSIESIIGNTDRKSPDIDIENNLSENSKTSEDDEPERNEDFNRMRYYLNAPFLHQSGVSFPFLLGYPEPWLSRVLGSNVATQNMSTESREEERRESPLSVGSEVESDGAEDNTQGVQSNSSDGDVSDGMVDKKRRPSTAASAPRPLAVAASDCQKSQTLGPRPLNEGNDSEPDLEDSSTDTTRENSKARRRRTAFTSEQLLELEREFHAKKYLSLTERSQIASALKLSEVQVKIWFQNRRAKWKRVKAGLASGSHSSGKNGSGTKIVVPIPVHVNRFAVRTQHHQMEKQNGLQFRLDRTQPLPGSLLQSQTSAFLSAAKVNSENHQEPVLLNPVLSRNTIYDASMSARLATLSQATTLRHYPNHNGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5L3</accession>
    <name>A0A194R5L3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="9">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5L3"/>
    <dbReference type="FunCoup" id="A0A194R5L3">
        <property type="interactions" value="1134"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5L3"/>
    <dbReference type="KEGG" id="pmac:106713245"/>
    <dbReference type="InParanoid" id="A0A194R5L3"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 9" id="KW-0385">Hypusine</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="17511" checksum="F7EA41C5CB584B08" modified="2016-10-05" version="1">MGDIEDTHFETGDSGASATFPMQCSALRKNGFVMLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFNGKKYEDICPSTHNMDVPHVKREDYQLTDISDDGYLTLMADNGDLREDLKIPDGDLGTQLRSDFDSGKELLCTVLKSCGEECVIAVKANTALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAG2</accession>
    <name>A0A194RAG2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAG2"/>
    <dbReference type="FunCoup" id="A0A194RAG2">
        <property type="interactions" value="1571"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAG2"/>
    <dbReference type="KEGG" id="pmac:106711748"/>
    <dbReference type="InParanoid" id="A0A194RAG2"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="212" mass="23963" checksum="189FE379212B845D" modified="2016-10-05" version="1">MGTREDEYDYLFKVVLIGDSGVGKSSLLSRFTRNEFNLESKSTIGVEFATRSIEVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLSYENVERWLRELRDHADQNILIMLVGNKSDLRHLRSIPTEEAKAFAEKNGLSFIETSALDSTNVEPAFQNILTEIYRIVSQKQMREPPEGDVIRPDAEPADVRPAADSVRKQCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAU9</accession>
    <name>A0A194RAU9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAU9"/>
    <dbReference type="KEGG" id="pmac:106711473"/>
    <dbReference type="InParanoid" id="A0A194RAU9"/>
    <dbReference type="OrthoDB" id="6362496at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="297" mass="33317" checksum="B270FF0DC3AAAB7A" modified="2016-10-05" version="1">MMSDGRSLLNTSATSSKIGCDEDPEVVAVKKYVKDLLKSRIFLGRYLERRLIDQLSCYRDIVLLSPAETELKRDLLEAEAKLRSIFSNGLWIGVTSAEKIGNSSGVCIWTEIDDQPLGAFWFQIKSVRFRENEVILALKCIRHISDAYLEMEPILTGSAKKNVESSENILDNSVVSLKESYNDLLISIKSALSITNVKEFFTFLIAFAIAVVTGSTTFVSFLGNFILALIREISIFVKNSTPMFLGILDFFGKIVGGFYILLAMLFKPNTPVRVSRRALPYDGQLHSYNQFSGKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB24</accession>
    <name>A0A194RB24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZIP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB24"/>
    <dbReference type="FunCoup" id="A0A194RB24">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB24"/>
    <dbReference type="InParanoid" id="A0A194RB24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF169">
        <property type="entry name" value="FI24038P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="305" mass="32488" checksum="527A74A19606C569" modified="2016-10-05" version="1">MEVSTAKALSMVALGVGSFVTGMIPACFTEGARQRHPLFISTLLCFGAGVLLSTSLVHMLPEAREKLPKYSELMLCIGFFIVYFVDEVVHLFYGGMGHNHQGSRYGSGEATRLLAHGNDGEMDRCCGDNGNQRICHVNHTPPCNRSSSGVIGLLCALFVHSLLEGLAIGLQETTSQVLLLLGAVASHKYVVGFCLGVELCASFARRLCLHLTCVLIFSGGSVVGIGLGAGMDAFSSMKDSAAVPIMQALAAGTLLYVTVSEVLPRERAAWHERRRAAGVAQLAAVAVGFALMYTTTLYLGKLSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB95</accession>
    <name>A0A194RB95_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED11</name>
        <name evidence="11" type="ORF">RR48_09125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB95"/>
    <dbReference type="FunCoup" id="A0A194RB95">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB95"/>
    <dbReference type="GeneID" id="106710814"/>
    <dbReference type="KEGG" id="pmac:106710814"/>
    <dbReference type="CTD" id="400569"/>
    <dbReference type="InParanoid" id="A0A194RB95"/>
    <dbReference type="OMA" id="WHRIQHV"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3490:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14723" checksum="C2C23FE71E72BD0F" modified="2016-10-05" version="1">MAGPMERIQVLDDIEKDIITCLQCAAQALLELGKEKSSQKQAETNTSQFLRTLSQVESKLSDQINYLTQVSTGQPHEGSGYASQKVLQMAWHRLEHVRSWVNELDRLKASHLAAANRPTPGIPNGSMTSSGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB99</accession>
    <name>A0A194RB99_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Valacyclovir hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB99"/>
    <dbReference type="FunCoup" id="A0A194RB99">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB99"/>
    <dbReference type="InParanoid" id="A0A194RB99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="229" mass="26178" checksum="681D6A9A475A5AC5" modified="2016-10-05" version="1">MPGALGTIWSDFKLQLEGLNRDKFTVLAWDPVGYGKSRPPEKEFTPDFYEKDADIAAELLKQLRIPKFSILGWSDGGISGMILAAKYPSVVKKLVIWGSNSFMLPHEVEALKKIRDVKTWSEKMREPMIKAYGEEKFAQYWARWVDGMVAIAQAQDGNICNEIVKNISCPTFILHGEKDPLVDNVHVSHLHTHIEGSRIHLYPEGKHNIHIRYADDFNKKVQDFLLFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC27</accession>
    <name>A0A194RC27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein goliath</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC27"/>
    <dbReference type="FunCoup" id="A0A194RC27">
        <property type="interactions" value="992"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC27"/>
    <dbReference type="InParanoid" id="A0A194RC27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16668">
        <property type="entry name" value="RING-H2_RNF130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF23">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265068" evidence="11">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="483" mass="53720" checksum="411A58F1D142EDBD" modified="2016-10-05" version="1">MRREEMWSQLATLGWVAVMVGCHAPAGEFAGSRLATADDRFSDTFTAAYINITYPNEHGKLYTETSETGKYGEGFVGSSRGVAVHVRAAGPEGEKDHTGCKWPILLYGATYVLLSRITSEPNKEAEVKTGKYGEGFVGSSRGVAVHVRAAGDKCICLCSDVWAVVNNAWRANATAVLIYNDRDAPDLEKMKLSTDNGRNISAVFTYKWKGEEITRLADNGTRVMVAIIKGRQTITRITGVNKTSVLFVSISFIVLMVISLAWLVFYYIQRFRYIHAKDRLSKRLCCAAKKALSKIPTKNLKTEDREVQGDGECCAICIEPYKVSETLRSLPCGHNFHKNCIDPWLLEHRTCPMCKMDILKYYGFVFTGSQESILQLEVEEARSRALSPARNRHPLTLLTSDNSYTAGSERSSRASSPDELVPNTVVTNTYHTVITDTYHTFVYIIAIWWSESGVLEAGDGLSELGQRRPRLNASNIGVFAHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCB9</accession>
    <name>A0A194RCB9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCB9"/>
    <dbReference type="FunCoup" id="A0A194RCB9">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCB9"/>
    <dbReference type="KEGG" id="pmac:106710624"/>
    <dbReference type="InParanoid" id="A0A194RCB9"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="37313" checksum="91D48F4B6B7FF5FA" modified="2016-10-05" version="1">MDKNKTTPFKNNHFITLVISVIAIPLSMSMWIINIIYSKLLGQNEGLDEPIVISPARWLAACFIPLLICVYGYKKKTLNLSGALLAFVVGFVLTLANLCFFADLLIFFFTSSRATKVKGHLKKKIEEDFKEGGQRNWIQVLCNGGMATQLSLLYLLDVGASERPINFMKDYRASWLSLGVMGILACCNGDTWASELGTVFGKGDPVLITTWKRVPKGTNGGISLNGTLFSTLGGLVIGIAHYLTVLYFSDSSLWLYAPPQWPIILLGAYAGFFGSLIDSILGATLQYSGVDKNGKIVSHSKHAVKHISGINILDNHSVNLISTIVMGILLPTVSKTVWPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCF4</accession>
    <name>A0A194RCF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_10770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCF4"/>
    <dbReference type="STRING" id="76193.A0A194RCF4"/>
    <dbReference type="InParanoid" id="A0A194RCF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCM4</accession>
    <name>A0A194RCM4_PAPMA</name>
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            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
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        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">RR48_09251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
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    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        </source>
    </evidence>
    <sequence length="1507" mass="162038" checksum="53C2E7CCEADB819F" modified="2016-10-05" version="1">MTESKPLAMANTNGLMDKSKELQKEILMEKLRSKTSQYKNLNETSKAVRMALLDKRWAVDSADRQILQKCLDSLQHCIKVSSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEILVESLGSVKDVKIHHEGKIEQQSCEEMVASITRGDFADFTAQLEGLIAVYQLNAEKKVKCKAFSALQSLEEDLCTLRQLQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKEKGLQPLTTELLTLGKPAASSGLASLVAPSHTPVGYSATILLEGSTANKLQLCPIISSGQRSGKGNGPVYAPLVPQNSAMLPACFTLRLSQPMPLCTGLAKLIHATTEHLPEQTQCYFICESRGLEGCVVRSVPFTHPSHVPPLLACLRQQALFNTLIASCVRLQNKQVVEMEGVVMLEVSAVSWQHISVSLEHPADESVATLELSLSEPAAPRAAVCTLHAPPSEHVDEYVTRVLQKSHSIPVTLRSLVKIWKMEAKQMNGNYSALDSNFSCDLGGLDPGQQHHLSMICQDPNSSESKPQTDERKSKKRKSDDLWSSSQKKGKQGITEAADSESDSDNSYVNEDDNTMNSNSTNEEGPESSVSQNEFASDLELSAMDATDALSTHDNRSSDMDNSNDGEPEEMIRNSFHKSEHKRQKLKNKESDSRSSRSSASLLLDLTDGKSYMPSSVSITPIGSSSSSSASAASGTNLSSMLCLDRRPGIEIIPISSATPATLPSSITITPITSSQLKSLDSRSDKKSSKSSEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPMRPSSPNSILRKFSPSPTHGRSVSITKSPSPSSVKSLGKPTGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKHSSSGSGKPSMSTLKSATTGSPSGKSGTTGYDLSKKISKDSYGSSSMTSRDKEKKHSSLSFSTSDRSSPKLKNQTKLKQLEITPVSCDSPVAEPLISPPNIEVNKSNTPSSQARNRKGSLSAVIDKLKSAHHSADTDIGSGKSGSSSSTNKFSDPKNSAAGSGMKVSESKNQEYMVKPSSDGMKITINKTRSKESSGSKLNYSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGLSTSSTPPKNNTSPSESSGSSSLPKVPYSKSSSGSSTGINLSKSASKTSSGSPKNSNSDLSKIIRDREREKVRTKLMSNSEKSIFSSKSERHSSPSSSRDDVDGDRYKASKEANFLVEGLIKPLDTSKFQIPKLKNQNTPDKNSPVSQYDSRSLVNDFARTLDQNKFPFSHFDNTNARNAESLQKSGYTLNVPKPLLNVGAMSPKTVSSSKLDQADRADFSKNLEGLGKGESPQRSKDDSKEGFPGAFPMMPLDFKTDMAKGFPAPKGSSEDRKGADSCMKPPASGSVARSGATTPQEAAEMLLDFSSSSGSKVSGMVAVRPVYPASPALALQLAKSPAPSPLVAPSPHSNSPCITDDELMDEALVGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCY1</accession>
    <name>A0A194RCY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemicentin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCY1"/>
    <dbReference type="FunCoup" id="A0A194RCY1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCY1"/>
    <dbReference type="InParanoid" id="A0A194RCY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF32">
        <property type="entry name" value="NEUROMUSCULIN, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="237"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="337"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="434"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="800" mass="87620" checksum="A08C168AD1E1432C" modified="2016-10-05" version="1">MLGIQCKGLRQGCWSVRAESLDAVNLSAVAGGDATLPCDTRSPQPPDALLLVVWYKDDVPIYSYDSREKSPSAHWADDSLGGRARWHAAPHAALRIRDVLPTDRALYRCRVDFKVSPTRNYKFILHVIELPEKPKIFDAREKEVVGVAGPYIEDTSLKLTCVVSGGKPMPRVRWWRDDKVIATLAPTEDGSRLSLLELKIPKLKREYFEAVYTCTADNTALVPPLRTNVQIQLYLRPLQVEILAREQPLSVGQEAELACRAVGARPPAIITWWLDDKPIVVTEPQKNSDDFNETVSFLRWTPRMEHDGRVLTCRASHVKLEHTTIETTMSLNLHYVPIVVLQLGSKLNPNDIEEGDDVYFECVVRANPPAYKVVWEHNGQVMTHNQRAGVIAGSAHLALQGVSREQAGKYVCTASNVEGDGRSPPVNLLVIYKPVCKNKEVSLVGAAVNEAAKVTCEVDAFPPPKNFQWTLNNTVGTVELEAGKFTVDGAGRSVLSYTPSGDTDYGSLACRATNLAGQQIEPCRYTLLPAVKPDPPSNCSSLNLTDDSAELRCVAGYDGGLQTTYVVEAWETEVLVANVSATAPVWKLHGLGSGKALTLVFYANNARGRSEITTLRVHTLSRLALQTEANTRSNRVDSSWALGIVAGIAGTLIAVTIIALVAKRKHHRPLQYEAPTQTAKAYKGSIQPVNHSPIQPDDKNPDVVPLGKDFNCTRDEERPPEPPPYGAVVSPPVGSSKSTHSLHDVRSNTPHTPNTPASDIQSIGTLAEDRRSVTSGTLSRRREVVTTRTPLLANARESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RED2</accession>
    <name>A0A194RED2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RED2"/>
    <dbReference type="KEGG" id="pmac:106709842"/>
    <dbReference type="InParanoid" id="A0A194RED2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443743" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="32145" checksum="80E762A1036AB787" modified="2016-10-05" version="1">MWVYLTLLLLSLSGLDLVPLSTKDIDISIPDDLDHNSIDGDGEDIDLSSLGPDAYGTPNNDSGDSLSTWSESSLMNPEEMGNYGQGDILMPPHHARNGMKDKTSRWPNGIIPYSIDGHFTQEQKDTIMRAIADYHRLTCLRFVPYNGQTDYISITSANTGCWSSVGRIGSRQEVNLQTPGCLSKKGTVLHEILHAVGFTHEQSRPERDDYVTINYNNVKPGSENNFKKSDSSYTSGYGVPYDYNSVMHYSEYAFSRNSKKTIEPKVGGVKLGQRDGLSRGDVRKVNAMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REI0</accession>
    <name>A0A194REI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/ethanolaminephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REI0"/>
    <dbReference type="FunCoup" id="A0A194REI0">
        <property type="interactions" value="1447"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REI0"/>
    <dbReference type="InParanoid" id="A0A194REI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="419" mass="45755" checksum="2E51F659E53224D0" modified="2016-10-05" version="1">MQFYKERILNAAQLKRLSEHKYSCTSASILDAWLQPWWCWLVSKTPLWLAPNLITILGLIVNVVTTLILVWYSPDARQDVPRWACASCALGVFVYQSLDAIDGKQARRTGSQSPLGELFDHGCDSISTVFIALGACIAVKLGEYPTWMYSPDARQDVPRWACAACALGVFVYQSLDAIDGKQARRTGSQSPLGELFDHGCDSISTVFIALGACIAVKLGEYPTWMFFQVGVIEAYCMLISLLTSTRSLKFNGTATAPMPRSRRVASCFCAMTLFYCAHWQAYVTGTLKMGRIDVTEAQYAIMAIQLVSATLGSDFWATKVGGLEVRYSLAGVAVVGAALTLGTLTTAILAGGVGKNGSTVAVSDNTFILGVWGLTMLRIYISCLRVIDQNLVNYIENFNHFTGFCTTLSGITPIPPTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF47</accession>
    <name>A0A194RF47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF47"/>
    <dbReference type="FunCoup" id="A0A194RF47">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF47"/>
    <dbReference type="InParanoid" id="A0A194RF47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="245" mass="27445" checksum="29AA733D3574D577" modified="2016-10-05" version="1">MLDKLGGVYAPRPSTGPHKLRECLPLVIFLRNRLKYALTGNEVLKIVKQRLIKVDGKVRTDPTYPAGFMDVVSIEKTNELFRLIYDVKGRFTIHRITPEEAKYKLCKVRAVGTGPKSVPYLVTHDGRTVRYPDPLIKVNDSIQLDIATSKIMDFIKFESGNLCMITGGRNLGRVGTIVSRERHPGSFDIVHIRDSTGHTFATRMNNVFIIGKGTKAYISLPRGKGVRLTIAEERDKRIAAKVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFL3</accession>
    <name>A0A194RFL3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RFL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1479" mass="168101" checksum="3E92410D3250D0D6" modified="2016-10-05" version="1">MSEDPLVHLPIERWGELKDVFKSDWPRSVSGFTILENMEYILKQGIDYGFKVYCPYGEPSNGMVAFNLKKTFNEIVIQTPKDDTSNLQEALKTSKLIDWTRQIEVPFAPKHVMDCVRRVNLEKNMKTVISRTETFILDKDMPLFKDIRLPDGFTFKPLTLEYVDLVNSTWPHRYDSSDWYFDLLTRANLGYGLFKQNDLIAWVFIKEMGALGHLYTLEEHRQKGYGELYPEIMNMSRQGARWVHKLGQQSRGGGGTNAVCRLSIICASNAQNSRLLQAPHNNGHGWDIRLAVPGQPGNDYPTLATIPRTSFSCAGREPGYYADTDTNCQVFRVCTVGATYGFQSFLCPNGTLFNQAVFVCDWWMNVDCKNSDEVLRNKNDQFENLKLGPQLMKDIKNILTHPVRNPFDTNTMKSKLLVMQSYKPPSGQLFPNGALLAPPERAPSHIYIPTKAIQIALRQNEYRPPSESFAASTSNPQYIPPIFSTFSPTTVRNVEILQRQVLNTQNIQNTNSQSNSSEQMISNGHAGQVQTQNRYTQSMNNFNNDQTNRQLQRYNNFRNTQRAQSNTEFNYVQTRNSYNTLQAARTFGNNAHQLRNKVKKNNISNNVSLLHPIKQQYTYETSRQPSAQLNQTQTSEKVKQSLVSSDIVPPTILTKTLTYSRLVQEPKQGQPKARITFKTWVLKPTKNANLIENPTPYTYNEPTKSIKEKLEFEGPYSYDKPSESVSLENTPEPKTAGYNYDKPSEPSFEITPTDEEVSPLYVSATTLRPSIKEPLLTTTTIQPTQASRQYLAPDRRNLPARQYFPPTESASIRSNKYFSPKSSLRQLSRYQNSESIASQTKSTTDYATSSRIRDTNPLQTKRVSNSNINHKNFSFYDYLSKEKLDITINEIVNDTDEIAGSESPENFGQYYQKLDSMASNSLPSESNSEDKEELTERPGTLPKPIKLVAIPSNKLEPPIETFDIYENSNKYTKLPFLKESMLPTIERTVSIKITIPESIANFIFKTPKDAELEILNTGNSNYLVLRNTENDITNTNFTPIGKLTWNENFNHSASQALVFSLLTDSINKAKKYNNIIQDNVQTLTTSPPPQFQAVNNEELGRISNTISQLTASQFTNNFKTHNFNNANTASVSKQKSNVSNKDEKLTYLKYMQNLAAAKQNDKSQFKANNKQLNPFVPDFRSNTNTDTPIYSGQLYKYPVPEVTRQIINAPNPAKSNILIQSDIDEVKSQRIVVPKNSITKNIDTSTNIKANIFNTQGTRNSPLRLEVSPSEKPQLKTENNILTTGTGITAQLRDKIVGTIPHPTDKNKFVTYKKDQSYYLYSNLSDGNSITNGQAAKQSVKQYPNNNYPDLITFHFIPSENQNEKESFQNEPQSYQLTELKPVENINSIELTDNNINDDTYSTDLANNIIRPSQKQRETINTLYDGPSSYSAPQLSIGNLISTQEGQRNNFNSRVEGLEENNNFSGYLKERPVRQFTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHT9</accession>
    <name>A0A194RHT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHT9"/>
    <dbReference type="STRING" id="76193.A0A194RHT9"/>
    <dbReference type="InParanoid" id="A0A194RHT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="377" mass="42660" checksum="574811F5B3F99F59" modified="2016-10-05" version="1">MTNLTHEDYLIRPPITQWSKIIREAEKIVGYPTSFMNLRWLLSDEFANMAMHLRKVVDSNHPLMKTAKSVIYNEHNNLQPWGLVILLLSKAVNPPMSPLQASKVNESQRNLAELTEMIRTGHSVHRGLLNIPRGKYKDFDTELFANKIAILIGDYLLVTANGMLARLKNQDLSYLISTALRDISEGEFFGDRDSQNMPLPGKPLSMLDLYEINSDTLPFDVTNVLGSPTKEWTLRTLYDGGSLFGRGCEGAVLLAGKGKKEQERAYLLGCHLSLVWQAASDLQKFTTNNKESFSLVSAPVLFALNESPDLYEEIEKFKNDLRELDYDALKSCVLKTNAIEQTRMLFSTNSKIASRYADMFGNCESIRTIKRLIETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI59</accession>
    <name>A0A194RI59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI59"/>
    <dbReference type="InParanoid" id="A0A194RI59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17564" checksum="C8CF0709655B821E" modified="2016-10-05" version="1">MARKLLLRQFKQLRSLRRFTTSVNLKNQEQYVIKSPLEDVIVPDMRFLDRLWLESPSFVNHVAISITWLSYSMRGIPAYGLRTNQNDRDSFDEYRKSKDYHPAYAGPNEQCKPFSACECYDISESVHEFRSQRLEPLNWGSTTKLAVHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJC1</accession>
    <name>A0A194RJC1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BRCA1-associated ATM activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJC1"/>
    <dbReference type="FunCoup" id="A0A194RJC1">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106708037"/>
    <dbReference type="InParanoid" id="A0A194RJC1"/>
    <dbReference type="OrthoDB" id="10057956at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038904">
        <property type="entry name" value="BRAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="108038" checksum="B84CFE0C05663F3B" modified="2016-10-05" version="1">MENAKIQSKVKLLFEKILQPHYVMNNYYADNLFIKINNTDPEVTYFKSLPFLSQLLVDSLDGFETYDNTVKVFLIRLLAVVCDNEVNFAKIFCRKGDMLAQAFNQIDGPSMNSSLRVAYMDVALSLLNHSSGVSWLYDSDAWKHILVLCNDKRTVFVVRKTYKFASKLMWELNHLGDMTKIITVLEYIMKPVLDTDYLAINLMTSEMEEEISKTLEPMLQMLLSIITNADELRKGNSMLIEYIIKKSNLITHCYVVLDKIRREDMTLLMTKILFAVGVARLLHSQPKLVNDVYEKENFIELGATYLNIIQFLIHRRSPTMVFDFCNACSEMWTRAWEGKAPAMIEADGKKFELHNQIVAMILVPSLVYANHGRSMSSSFTDERVDEFLVKLLNSMCYHNARAAYALRDLTVQLDILSITLQSVKRLSCWKNRFTNEQANLVFQALFFVLKQYDPVDDNGEMKNEITYEDSRDKVLVMTYVLDSLLSLVKTYNINWHESFEVLCLYNVVYHILKRPNLTCKFVVTALNVIAITIKKFLPPNLSLLMDSKPGSAMHELGKLIYMKLHDFHWEVRDSALELLLVCTEISFIKFPPIQNQILSNNLMTVTVTIALNDHEFYVRASALKCIGAATKVAPIWDDLKANFPNIQHMILTIMVDNPEGIVRKEACNVFCEIYHNLRVTPAFKQVLYECMLYTALNDFHWEVQLSALRFWKIVIQHQLNAQGMLDGTFPPVTFAKDSRKIVTLNEKEIQKRLLKTLEELASIGCLTVLVKLLQDESEVDIMEAALSISIELYSVLEKYKVPETLQADDSEMVNVDETDRPIKLIDYSTVNSGANNASNVDNVIEGIVKADDINLLAMMYERQMKLQNEEMPVNDQPPKPKLLKFASPHLFVTFLKSKDFKAVIEQKKKWREGIKSLSSLLDDVLGIYEINDDVNTLDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKG4</accession>
    <name>A0A194RKG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKG4"/>
    <dbReference type="FunCoup" id="A0A194RKG4">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKG4"/>
    <dbReference type="InParanoid" id="A0A194RKG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11301" checksum="81843BB2ADE242F8" modified="2016-10-05" version="1">MSSIIQKCNDDNIPLADDDPQVIITDDNENNRLDHGRSMDSLPSSYTGGSSSPGLNGPPSFEPDSGIDEQEEKARLISQVLELQNTLDGKYQIYISYSLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLF1</accession>
    <name>A0A194RLF1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vitelline membrane protein Vm26Ab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLF1"/>
    <dbReference type="InParanoid" id="A0A194RLF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265294" description="Vitelline membrane protein Vm26Ab" evidence="2">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15885" checksum="515176FCA4D90DC1" modified="2016-10-05" version="1">MSNRKSPDMYKWVLFACFLALATEQVSALPVTPPDVETYNAPAYGSHAAPLKFSDYSAPAGTYSDQKYAQPYSNYFFIFACFLALAAAKPGVLPVAYTAPVAAAYTAPVAAAYTAPLAYSAYAAYTAPVAAYSAFPYAAPYSAYFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM73</accession>
    <name>A0A194RM73_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM73"/>
    <dbReference type="KEGG" id="pmac:106708723"/>
    <dbReference type="InParanoid" id="A0A194RM73"/>
    <dbReference type="OrthoDB" id="6424379at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="56995" checksum="F557CDCA3BDD301E" modified="2016-10-05" version="1">MDERNNDSPREASSRAIWTVKNVWNESFTSIKRDLLESKLTDTIKYFFNKKDQNVPNVNKEVNTEILTAEASDIKSERLIANEVRNIEDDLRNEEDEEIRKNVWSDVDDELYIANLIKLRTSNEDKRVKRDTSAHISVSDIGDKVVNSVKLDYEMWELEPTDLTECDCLGPPPEFLLPPPPRPPFLQAEYYCGDDPIPDLETCDTEPKIDAYNHSGPSFQTSAVIALCSVVLLVGVLVGAVLVWKHKRKVTNFLPSKSSAPSHSGGSQRRASPQAPLYEDLQDLPRRPPLPHRPNIEPQLEMVETKRPNCPGRVFVCDSGGTWRGGNSCGGDACGAPLYEELPHRSDDSIHSDDHFAEDELSLVGEAAPCRTCSRPTVPHSLPHRQRPQRLDRRPKSLERRRGHHRMPRHMHPPDPSEFHEGVLLDALLRLYPQVGTVGARPPGPLPMQAGGAWPGGELPGIACWRGPRASPKPPSGDSSFGSDSGYSNNTCGTCGTRASSRHRLSAEIPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMZ5</accession>
    <name>A0A194RMZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein son of sevenless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMZ5"/>
    <dbReference type="FunCoup" id="A0A194RMZ5">
        <property type="interactions" value="1189"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMZ5"/>
    <dbReference type="InParanoid" id="A0A194RMZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22914">
        <property type="entry name" value="HFD_SOS1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22915">
        <property type="entry name" value="HFD_SOS1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="206"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="477"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="632"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="828"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1268" mass="144873" checksum="24B9824E60DFF43F" modified="2016-10-05" version="1">MLPTVEESRGYDFQDPDNAEKWRGLFVNSLRKVLESVHPTLTAEESALEYVESLCLRLLAMLCAVPSPLTVQDVEERVARTFPTPLDKWALSDAREAATNRRRRLLLPLDKLHNLLQKEVLLYKIDTSVSVFMTAVLEYVSGDILKLAGTFVKKISQKSGYQTISCSDIKTAMCADKVLMDMFYQEPELLAAGAAGERRGRRGSLTYGELVRDLLADERNFLRDLHLIIRVFKDELEKILERDSRAISLIFGNIVDIYELTVTLLGNLEDAMEMSQDSPTPYIGSCFEELAEVEEFRAYVRYANIVTRKESREALQNIVDDPVVKLAEVEEFRAYVRYANIVTRKESREALQNIVDDPVLSERLDTAGHGFRLAVKYYLPKLLLAPVAHVFLYHNYILALLQIAPASEDRESFKQVECNLHPIKKLLTKALGNGPKMEATLRTAARTRRQLAIEKCNELARLVDNWDNRDVGQWCNEFIREDTLSKIGPGKRIAERRAYLFDGLLLLCKPITSLVAVNSSGLTAGGSGGQQLKLKEKLHVRKLELVDRPDTDEGRHMVELCPRVGPPVLLAAASCAEKRNWMCDLVMLNTKPMLDRSLDRIIGEYFNHFPIVSNLLHFITHVTIYTNQFTFGHHTYRGATLLKLVERLTYHIYADLNLVRTFLTTYRSFCSPSELLDLLIERFKIPEPSEVYDAPRIDCVESTASSDAEKLSKNTAREDWKRYRKEFQQPVKFRVINVLRHWVDQHFYDFEREPALLERLRDFLESVDGKPMRKWVQSVLKTVQRKSGQNSELELGGGVSHVFDKAPPAVLRHVADPEKHAWHPLVLHPLELARQLTLLEFQLYRLVKPSELVGAVWTKKDKDKTSPNLLRIIKHTTNFTRWMEKWIVESENLEERAAVVCRFLELAVALRDLNNFNGVLAVAAACGSASVHRLRATFQLAVALRDLNNFNGVLAVAAACGSASVHRLRATFQMVPLRLIRALEEFRELNSDHFRRYQERLRSINPPCVPFFGMYLTNILHIEEGNLDFLPNSELINFSKRRKVAEITGEIQQYQNQPYCLTIEPKTRAFLESLEPFPGMDDNEVTNYLYAKSLEIEPRPPVKQMPKFPRKYPELSLKPVKLSRRSHDSTHHSASSASSADDNLSVSQLSPTSGSTWDGTSVASLQLHHEDKVELITSLPRKYPELSLKPVKLSRRSHDSTHHSASSASSADDNLMRNLYEREPKDGHEREKFLGALDSRLSRFDFTTNSHPQPRRINRDYGLYLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNE1</accession>
    <name>A0A194RNE1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein DGCR2/IDD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNE1"/>
    <dbReference type="STRING" id="76193.A0A194RNE1"/>
    <dbReference type="InParanoid" id="A0A194RNE1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="48741" checksum="F1B5A31640726997" modified="2016-10-05" version="1">MQKRKREKQRRDETTKNSRRMISIAAQGECTDLRGRHISHGLHYVPGPDTCTLCVCDNGLPKVCKAVLCSPPQDCRSFRVGNTCCEFICLDDVVKPAEGEAGVRVAAGGAAALVVATVALVVYRVRTHKRRRPPRLDDQRSLTSIGYISGSMGYMGGTCETALAAWKPPSNYLPRGEAPPPYDEAVAQCRVDSMRMNNESFHRSYAGVEGDMQCSGHAYVNVPRPVQQIANTQSCYNAPLLQAVHAADGRDPPIVPHHALPSNVVGFPSTIRLTGSLGAISGRGVSVGGAGAGQTAPPPPAAPPHADHERPHNVPGFYTHLHPIHTSLHRTIPRISTGMETSLSESVSGFLRADSHRVCVVTRVVARVGVGGAAAGEDADDYRSECENCKSATSSRWVLEEGWDGEEEEGGTQTLQRRAPPPAPPPPATATLPQPVTKLRYVCHTVQGGGAKGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPK4</accession>
    <name>A0A194RPK4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPK4"/>
    <dbReference type="InParanoid" id="A0A194RPK4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265356" evidence="2">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="152" mass="16966" checksum="2E9FA8995D53F739" modified="2016-10-05" version="1">MCVWWCQGVSMRVWCMVAVLIVVALWATAEPAPHRYRSEWRAARGSRELARPLRDLLEPESAAASASASEHRERRRAHNSKRASYLPAEIPGSQTMLRASRSNRPYDVPQIASLGATLHNNIGAELTPPRKLFIFNGSSEFCLHGITEVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRP6</accession>
    <name>A0A194RRP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cep192/Spd-2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRP6"/>
    <dbReference type="STRING" id="76193.A0A194RRP6"/>
    <dbReference type="InParanoid" id="A0A194RRP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135512" checksum="4F112CA6DD9F5D19" modified="2016-10-05" version="1">MDNPLTPNKILRLLHYAEDKSFSLKKRLAQEDEEKRMDTQEGTTNKSSMHLESSSGILDLDKVEGFGEGGISIMSFNKSSAFNPGEMTGRSTGTDEVKVHKERKEPGKKPDAYDEYGRHSFALESLTSNLEKQTMEVNDIMRHSIASNYSFHSKKDMTAEEASFVLNHAPLPVQQSTQVNITADNLPENTTNMSVGGYFQDRCPEFKNIFQMTDSPIRSVRPSISEVSLSTPLNSISNESKKTYVVDQSLDCIPVRQSRAANNDAVKIKESTFSMARNFTVPEISDSSCSTNMSPAKNDLFKVPMSKVYDQEDSSNIKQNLLQKRLLQSLNVEQFLKKSSPFQIPTEESGVSVDNDNENSLSISKIADYLGKQSNVSITGMMQLTNQKHAYKKEPLSELHMNLQNNTRANDRMSVTNLKGTEITSSTGKMSIVTSLESLKIREKKTVPTVVVTPSLNKTECSDTDSRKRISRSKSPSSKSPSTLSTVQENHNSFKSNDSPLQKSKGEANLSHVASPNLQYKELDNSVDWREVLQHKSRMRDRLVKEQWVEIRATAVKGYVGTSSDATITITTLTDSWLTIKLHFLDLPNNGKDLTIELPRQPLLLSPGKTEQLKLYITSNLEINTTLPFKVCLRDSSLDADIEQMGKLDVDFKMPTIQAISGDGMNKIIFPTVQERCSTTKFFVIISDCPVDLQLDLSIIENNDVFTIKNVQEIRQSEVNKVLMERDIEEDKTGKSKGKHLNKQLCRLTSGNAIKVSVVFTAPKLTGMDCNENLTKFKGALNINLIGIKDVLNKVDLYGDVGSAKLQVDIPPHKLHISNEPKTIMLRNSGSMAGTWFIRIKHKSLNDYNVPFQASLQRVEVRPGADKELTITYKGSQDEFVEGTLYFEEAHTGNKTNIDLTGGSDKPKVFPIKTTYRTMSWVRSGRKELNLRNSTNKKIQLRCHIIGEGFTIDLPGVESRGTYCLSFGPNESRSLPVLFAPSSPAPHAAALHLVYDKSCDFSRKVQLFGVCSGSCVRWSGLVTYGDTALVRAVARQPLSLPLYNKYNVPAFICAHLRFNLQYRCCEESAVVEGAQCVVGARRRHTLQLRVDWARVERRARTQPAAALAALTVLAGPEITRRRILRIIRNKTTGELDTSLLPAHLRVLAQDIEGQEVVSDEALKDFEETISSLNELIESLQELSAQIDLPQDFADEHTILISDDTVLDHHTLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSJ8</accession>
    <name>A0A194RSJ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSJ8"/>
    <dbReference type="InParanoid" id="A0A194RSJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="235"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="525" mass="56583" checksum="9F1CF78BCD90C89B" modified="2016-10-05" version="1">MDKTRPTQNKAKATGSFHASTSQPVKAGPSKSSATTSKGGGKASANPTPTTSADAQNNEAAPTAPVMAPPSPPQRIDDDLSAAWQVVSRRAKDKAPKRNLEPTKTGTTGEEPAGKPKKWKRPTKLQRYRAAQLKAQKGELPRVTESPIPDQVSPQAGPSGQCATGSGRRPPEPTTISGKGTAPVKGKAPQRPGKETRAGKRALNSSTSPRGDHKKQKVERPSRTTAISYSDAVSSDLKVAVTCARSGNLTREIANTFIKNMTQAMVKVAWKPEGGSSDQMPVFVTRPTYVEGAIRVTCEDQLTLNWLKGIAADPQMCQGNQLVVKPQADLPRRVRCGMFVPDQFDLLTDTRDIGRLLYRQNRWIDIKEWQFLDGEKQAEGWFIKVTIPETQIPTVLAHNRRLACTINQCYLKFLGKGGKYYETPQTSTPAQPTDMPTPQEQEQNTRDKVADDASTNSSAAEQTKGDQTSQDPQVSIPGTSGFQQVSSPAAGESLVAPSRSMIALCSLTEAAKDSKRASQAPSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RV89</accession>
    <name>A0A194RV89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein C1orf31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RV89"/>
    <dbReference type="FunCoup" id="A0A194RV89">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RV89"/>
    <dbReference type="InParanoid" id="A0A194RV89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="13054" checksum="0E0B399B4492D714" modified="2016-10-05" version="1">MTLNWIDSSIPKPQVGTVPHGRLLVGGKMSFPDRAQRKTCWDSRDRYWECLDSHNIRDSSRIPKECTEYRMIFEKSCPPKWVTHFDRKRDYDLFKEKMQKEGFEPIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAU2</accession>
    <name>A0A0N0PAU2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAU2"/>
    <dbReference type="InParanoid" id="A0A0N0PAU2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26555" checksum="1E9D6261D02F8495" modified="2015-12-09" version="1">MTQSEAATEIEKMRALEERIKAPSIWGRLPCGIRFEDLQDTRYDDAVKLLKKHYLPEESFLIKIYISLGAFSRTFSRVKLTHNPLYSKVMKFYNEIEKPIDLFKEMGVRRYLKFYVIALKGRYRHRGIAKEMLKAARELAASANVPAIAGIMTTSRGQVIAESLGFVKYNEIYYIRYLIDDQIAFFDTGLGNYGAALMGYRIPDVEEPVEVQPQRSSRFNIQPITTEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAY6</accession>
    <name>A0A0N0PAY6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-binding protein 5-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461113">
        <property type="protein sequence ID" value="KPJ08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAY6"/>
    <dbReference type="STRING" id="76193.A0A0N0PAY6"/>
    <dbReference type="InParanoid" id="A0A0N0PAY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF8">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="432" mass="48223" checksum="46EC845BCE9FB0CA" modified="2015-12-09" version="1">MNDSGAECSEALDPRVQIELERLNTATDEINRLEVELDEARLAFRRLLAEGHLRIQQLTKKLGTSVHKARPYYEARFRANFTSQELQAATLAYDKANSAHAAAREMVYLAEQGLARLAEGSEGGLTLDPAWQEMLNHATHRVNQAEADRATATVTQRTKAAAHRAAATLVQQLQNGLKRHIAKSRPYFEEKARINAALEAQKARIQTLEEQVAEAKQAILLQHLEISKEYPMKYIDIGQGDSLLRNGVDIEASIVSEIVRLHTAHLGGPSAPFEKCSLRPRSTPEKTPSPPSPLESKVSAASPRRIIRSERTALRNELRHELRHELRHELQNARRQSLDALLHDTGERVKEMFQGGKQARDQLNSPKWRSPTASSASSDRHSDTDSLPSVEMLTDDQIASLMLDAQLEAVCERLAGVAVRQPRSPHSPEARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAZ7</accession>
    <name>A0A0N0PAZ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 4C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03624</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAZ7"/>
    <dbReference type="STRING" id="76193.A0A0N0PAZ7"/>
    <dbReference type="InParanoid" id="A0A0N0PAZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="453" mass="52125" checksum="342EAC76D7897EDA" modified="2015-12-09" version="1">MLVLGLSVIAFALYWTWRWRVTSRLEPPAYPGGIPFIGHAHLLIGDSIVVTDPDDCLTVSNACLQKDNFYNFAKPWLGEVPIWKHHRKLLNPAFSQLVLDGFQGVFNSQSRRLVRDMAAEVGKGPFDHWAYTRRNALETICLTALGVDFCENSVLNSQYEHAAEQMFNVLVERFQKFWLHSDFIYNWSSLKKKQERCLEILHNMSNTVLKTRKASYLNNKKNGLEASTGTKFKAFLDLLLELSIEKGAFNDLEIREQVDTMIVGGHDTSANVLMFTLVMIGSYPKVQERIIEELHDIFGNDDRDVTKQDLSQLIYLEAVLKETMRVYPIVPVTARWLDRNVKLKNYTLTAGRTCFMFVYGVHRHAMWGADAEEFKPERWLDPATLPHSPNAFAAFNMGRRICIGKTYAYLSMKTTLAHLLRHYRVQADHSKMVLKLDVMLKPECGHFISIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB67</accession>
    <name>A0A0N0PB67_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB67"/>
    <dbReference type="FunCoup" id="A0A0N0PB67">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106717425"/>
    <dbReference type="InParanoid" id="A0A0N0PB67"/>
    <dbReference type="OMA" id="MCLDSAP"/>
    <dbReference type="OrthoDB" id="8180181at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22100">
        <property type="entry name" value="F-box_FBXO28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF1">
        <property type="entry name" value="DAMPENED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="500" mass="55692" checksum="3D464B7464ACAFD0" modified="2015-12-09" version="1">MVSTRQMSSIGSSNSGGDGSGPSHAEPVTVARVTRHSSALLPGGSSPHAGSSKNTLAPPPKVFTTNFLDMPTEVVEKIFRILGFKAVAQLRLVNRQFNTICSGLLNSTFQRLQNQMLHRFQSIKAKMPRRESARRSHPLACESDIIETLHMRLSLLQMTFGKHIERKHCCFFPGEILDEVYGILSYLKTATKLARPYKVTDELFDLTTMAMEYFKEHIEPNLPEITYFGTDFFDITNAFSPGESSKSYLCLDSPPPSGFEARSAAPGGSSAGDRDTSVMNPYLEESLPPSPPPPQSNMVLRKRIHRIKQGMKKYNDQLSALRTDLRSCKRKTALQQKQIAEQQKQIAEQQKQTLEYANRLDDYDKKNEETSRKFQTLLQELNKCKTELQYWRSRSPAVPPLCAECGASLRLSPAALDQWATAETETNETATAGGSKDAAVTPASTEPEPVTEIPLKNDHKSEASSGEESTNTPPTRRRASADATATPDRKKRRLTRPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC77</accession>
    <name>A0A0N0PC77_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC77"/>
    <dbReference type="STRING" id="76193.A0A0N0PC77"/>
    <dbReference type="InParanoid" id="A0A0N0PC77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13561" checksum="D251FC828A270518" modified="2015-12-09" version="1">MHKGYTYYQHVGSRMFYCSKRKSGCLARIKLGKDETIRYKFIPSSKVKGKQWILCEKYTYAQHMYGLLYYCTRKNSGCKARIKLNKHGNVTAYDPCHLHEPPLYYVTSKGKYVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDB4</accession>
    <name>A0A0N0PDB4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460253">
        <property type="protein sequence ID" value="KPJ16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDB4"/>
    <dbReference type="FunCoup" id="A0A0N0PDB4">
        <property type="interactions" value="1500"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDB4"/>
    <dbReference type="InParanoid" id="A0A0N0PDB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="21285" checksum="BBBCC586AF8E697D" modified="2015-12-09" version="1">MAIRPVYRPTIVKKRTKRFIRHQSDRYDKLKRNWRKPRGIDNRVRRRFKGQYLMPSIGYGSNKKTRHMLPNGFRKVLVHNVRELEILMMQNRKFCAEIAHGVSSKKRKTIVERAQQLSIRVLVHNVRELEILMMQNRKFCAEIAHGVSSKKRKTIVERAQQLSIRVTNAAARLRSQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE28</accession>
    <name>A0A0N0PE28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfotransferase 4A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE28"/>
    <dbReference type="FunCoup" id="A0A0N0PE28">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PE28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="269" mass="31703" checksum="00FFEC0AFC73973F" modified="2015-12-09" version="1">MRTKPVLTFSKLDEETGEMLDRMFEKKDCMVEINPGRVILPADYMSIGQDILDMEVLEDDVWMCSYPRTGSTWAQEMVWLIGHDLDYEGAKSLQQIRCPLVELSCIMVDGHAQWHEESVRGTSVDLVKHRLAHPRYIRSHLPWDLLPLDIQRDDGSAKPKVIYTSRNPKDMVVSYYHYCILVHGLKGTFEEFCDIFMRDRAPFGPVWNHILELRYLEKSFGRNYLEQTDLRFIRKGEIGDWKNYMSDDLSRRFDDWAERHLKGTELSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEN0</accession>
    <name>A0A0N0PEN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459719">
        <property type="protein sequence ID" value="KPJ20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEN0"/>
    <dbReference type="InParanoid" id="A0A0N0PEN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="309" mass="34433" checksum="8106A229E6BD82B2" modified="2015-12-09" version="1">MNESPSRSERISFLKAGNASAILLVLRMSMGVDDHFGVPVALLKTFKLDPKRSAEAYRPSELSNRKTLLVQPFLRKNQTEKKPYLLETPIKRKPALLRTPEECKRQKINSNTEEAISTEKEPSEFPKNSNNHHQCCCKRVEKENSCSYSKTPEENCAHKTRPENCAHSNTQQEKSCPSSKQENSYDLTKQDTICNCSKKENICLCNKQDNCNHNKTQQENSCACSKQENSCGCSSLPIVFTPVMMPPAFGSIGVPYMIGQPVKFNKPYSTGSCTFVIIISLSSFTAECRLPPSIATMPGPVPPLSSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFE6</accession>
    <name>A0A0N0PFE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01026996">
        <property type="protein sequence ID" value="KPJ21151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFE6"/>
    <dbReference type="KEGG" id="pmac:106707369"/>
    <dbReference type="InParanoid" id="A0A0N0PFE6"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ21151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="470" mass="51049" checksum="B9BB5EFA8F90782D" modified="2015-12-09" version="1">MERPEYEYDRIEKLRRIEMDTSIKFQLLIVACINIGQIVVGYSVGWSAPIIPKLQDNSTSPLPEPITDLQASWIGSLLYIGAMSGPYVTGILSNLIGRKPCLLIGGCINVLSYILVITTKNVAMVMALRVMSGLGMGITTVCNIVYVGEIASTNIRGILLTSTGIVGITGTLIVYAVVPYVSYVATGYIALAISIAHVLGLFFFVPESPVYYAMKGQEIKTAKTLNLLGRSSDLDKVLETFAHKKGETSSKINDWIEIFTIKSNRMSLFITFTLGALQQTSGVAVVLFFATTIFQLAGSSIRPDLATIIIGVTRLISSLIAPTFVERSGRKILLLVSMVACAVSLGVLGLYFYLDRVKSPAIESIGWLPLVALIIYFFSYEAGFGTIPNAIVGEMFRANVRANGSALAITLTWLVGFGLTTGFNSMIDALGGDVTFWIFGGSCIVAFFFTYFFVPETKGKTLNEIQEMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I560</accession>
    <name>A0A0N1I560_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I560"/>
    <dbReference type="FunCoup" id="A0A0N1I560">
        <property type="interactions" value="1596"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I560"/>
    <dbReference type="InParanoid" id="A0A0N1I560"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17527" checksum="75B3DCC23D840824" modified="2015-12-09" version="1">MENVGSLEEQALKRKERLKNLKRKHPSDENSSTNTSNAEAVVLPKPKFRSYRPQDETLQEAKLDDAQPAVVDNEVKDLLEAGKEKVVLQDLDISSLAPRKPDWDLKRDVAKKLEKLERRTQKAIAELIWERLKDGAEDNLGALVTMTNKVPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I822</accession>
    <name>A0A0N1I822_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0528 protein CG10038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I822"/>
    <dbReference type="FunCoup" id="A0A0N1I822">
        <property type="interactions" value="1935"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I822"/>
    <dbReference type="InParanoid" id="A0A0N1I822"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="157"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="291" mass="32533" checksum="02B2213D887F9102" modified="2015-12-09" version="1">MADVTMALSDMGYAFNADGQLRKLGKYKMLSAEPFQFDISTDPEECQANYEKLGAVVTNYVYQLLESQEKMIRLPVPKDSTPENGTFIFVSRDYDLKDVLLVLIQGSGAVRAGQWSRALIINESLDVGTQIPYVRKAIGKGYGVMILNPNDNCRGDNQKIPNSATGEEHAKYVWDNYIKDTKASKILIVAHSYGGVITVTLADQLKEEFEQRVKGIAMTDSVHGYSEFKVTDYLKKVSKNWISCSTPLDTPMKTPEFDITRVSAGHPRHEMTSAKCIDSVFTFLEKKLTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICS1</accession>
    <name>A0A0N1ICS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICS1"/>
    <dbReference type="InParanoid" id="A0A0N1ICS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="38143" checksum="D3A1D3CCE45CAE7F" modified="2015-12-09" version="1">MLKPFIYPLYVHLLKSRTVGHGRGAPASGERSCRRNYTLYMNTLRQHAAAVTYWHTPPGLYYTSYWSTPQGTHEGAGEALRRRPTARRATGDGGRLSCRSARSHAMAAARPFALPLVALLIALIAVLLAPAAAAPRARRQLADDAALQPLDRSDGEHFSVTSRVSMMCARSWATPCRGGRLRHRPPRALGNPPLPSARPSPAIPLSLKEDAAEDEQTREKRKLEGVTQAKFGIKNAVLGFVFGKINSLIDAKTRFVDTLDRQNIELNKQYGIEPPAPGGLASLSGVVTQVIGPKLQLLGPKLQAVTGLLGGLSGGSSAQGGGSGGSGLGSILSLVTSLSGSSSGGGGGAAPSVETVDSSEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE76</accession>
    <name>A0A0N1IE76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trypsin, alkaline B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_00574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01028292">
        <property type="protein sequence ID" value="KPJ21177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE76"/>
    <dbReference type="STRING" id="76193.A0A0N1IE76"/>
    <dbReference type="InParanoid" id="A0A0N1IE76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="240" mass="25799" checksum="A341677D45A4A071" modified="2015-12-09" version="1" fragment="single">EEFPYIVALTYTYPGPGITVQRCVGGLISSWHVLTSAFCFTGANLGNFEVRAGSTESLSGGTVSTIRDVTKHPDYQESPLANDIAVVLLQTPFAITNNINVLFLPPQNTFIPDGQSVKVVSWGFETMTGPQLQTLKKVYLKKVSLDECSAGFENVGNVAVSDSVICASEEGAVGTCRGDSGAPMVIDQVVVGISSYFHECGDDLPDVFTRTDRFTDWIVSVATAPNDDDVTPVRVKSVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEW5</accession>
    <name>A0A0N1IEW5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="12">ARD'</shortName>
            <shortName evidence="12">Fe-ARD</shortName>
            <ecNumber evidence="12">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="12">ARD</shortName>
            <shortName evidence="12">Ni-ARD</shortName>
            <ecNumber evidence="12">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_03583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="12">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="12"/>
    <dbReference type="EC" id="1.13.11.53" evidence="12"/>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEW5"/>
    <dbReference type="FunCoup" id="A0A0N1IEW5">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IEW5"/>
    <dbReference type="KEGG" id="pmac:106714153"/>
    <dbReference type="InParanoid" id="A0A0N1IEW5"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0533">Nickel</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="184" mass="21909" checksum="5313BE7AEFCF99DA" modified="2015-12-09" version="1">MVKAWYMDNDKTDPRAEHQRNPPEFISIEELHRKTGVELFKLDLKTYESEGVLEKIKKDRGYTYEDEITISKECLPDYDEKLKSFFTEHLHADEEIRLVTEGSGYFDIRDGLDEWIRIKVTPGDLIIIPRGSYHRFTLDNNNYLRARRLYEDEPGWLTHIRPADDMACRKKYVEQQKRGFSSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFH0</accession>
    <name>A0A0N1IFH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Small conductance calcium-activated potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFH0"/>
    <dbReference type="FunCoup" id="A0A0N1IFH0">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFH0"/>
    <dbReference type="InParanoid" id="A0A0N1IFH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000022">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000027">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01451">
        <property type="entry name" value="SKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="12">
        <location>
            <begin position="416"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="629" mass="69834" checksum="EFB3EF9527079C39" modified="2015-12-09" version="1">MSMGRGRFVVSANSGGRLLLRKPVSTVSIPGAMKAYSGGRDAGAEEAGVALVGVHSEYPRFGEERALGGGTYKGGGTAKHKPNIGYRLGRRKALFEKRKRISDYALVMGMFGIIIMVIENELSSAGVYTKASIYSQALKTLISMSTVILLGLIVAYHALEVQLFMIDNCADDWRIAMTWQRIAQIALELAICAVHPIPGQYTFTWTTKLANKGGVIGVEVVPYDVTLSLPMFFRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRGAGCTALLVTVASRKLELTRAEKHVHNFMMETQLTKKLKNAAANVLRETWLIYKHTRLVKRVHPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKDPFLLQTQNTVYEIVSDMSTRQDTIEERLTSLEEKLTSLQEQMNTIPDIMARCLQQHWERTEQRRNYLHPDTAAVPTPPSSTITPYARPLASASHPWPPSPVGHQAARAHSAPESTAAHTPTAQLAPTSPAPAPPRTQLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFP2</accession>
    <name>A0A0N1IFP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFP2"/>
    <dbReference type="InParanoid" id="A0A0N1IFP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="15466" checksum="113FC8FBCFC92E1D" modified="2015-12-09" version="1">MNSSDEHYFIGHAESYQLVAQHPRVDRGYECRPTISPRKGQKKIWRTDRQPSLVEEALQEEEEEESYQKGECGYKYHEPWGKARGYVGLLPVPGPEWDRKKESIPTKPLWFPLPHHAPGRGDTNVFFNTSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGX1</accession>
    <name>A0A0N1IGX1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459805">
        <property type="protein sequence ID" value="KPJ19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGX1"/>
    <dbReference type="InParanoid" id="A0A0N1IGX1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="434" mass="48334" checksum="D2A87620F83C5289" modified="2015-12-09" version="1">MDIVKCNNCNIVICELLAFVQNKADVMDEDSILRLCSTAFTTDEITQAKKLLFESVQTTSRKVNRKGEGKNKRDMEDILCVIKETDPDLVPIFVARDLQRLPPVTFDHVDVTRLLRDIIKLQDNVLFIKENYATKEMVLNQIGRPHISTEEFQTESTDIINTSCIDNSMTQRPVAHSLSSDSLARKGACNYDLSLSRPTERLTGETGSGDKRSAVSPARVASRPARIEVSQPGNNSYADAAARAPLASETAGSSTSASNMKICKNDDWVLVQRKRNKNRFTAMTGKADSHYNTFKAANTRIPFYIYNVDMKCQTEDISNYIMSKTGVDVQLEKVNMKFKKDYGGYKFMIPKDKLSIFMDENLWPCGVSFRSLTGAVVTDLESTGIIAQRRLTSGVNASHCRASDAKSEESTRAPGLDKRGTQTTSVMLLSNEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHW1</accession>
    <name>A0A0N1IHW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOXD1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460017">
        <property type="protein sequence ID" value="KPJ18451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHW1"/>
    <dbReference type="InParanoid" id="A0A0N1IHW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="20559" checksum="081CB8A3FB8A57AF" modified="2015-12-09" version="1">MHAGVKCNDTVQWIPIVARMTHDSMKPTVPTTVFLAALNFARVPAQNTMLGVPGFSEMRREGTAQRADDPEPPIYSKRVGLMIPDDGITIVSVLLHAHGTAKKISLKHIRGNNELPKVSEENSYDVRYQQSRIVPGGRKFLKGDTLITECTYDSTGRDKPILGGDVPIIRAVLPSHAARRLLLHDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIC1</accession>
    <name>A0A0N1IIC1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01057479">
        <property type="protein sequence ID" value="KPJ21579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIC1"/>
    <dbReference type="InParanoid" id="A0A0N1IIC1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="13221" checksum="DE0CA7968979A8E8" modified="2015-12-09" version="1">MAFEGKVYVHDRDENFEGFVATLGLSEDNVQKLKNSKPKYKLEKNGDTYTATTFSDKYNRVVTFKLNEEFDEAVVDGRNVSIYTHRKRIFPLIPTNPHFLPILTFIRKGWEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJW4</accession>
    <name>A0A0N1IJW4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETFB lysine methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein N-lysine methyltransferase METTL20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. ETFBKMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJW4"/>
    <dbReference type="STRING" id="76193.A0A0N1IJW4"/>
    <dbReference type="InParanoid" id="A0A0N1IJW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050078">
        <property type="entry name" value="Ribosomal_L11_MeTrfase_PrmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="216" mass="23727" checksum="FCCCCB937ABD1346" modified="2015-12-09" version="1">MRNQLVSQIIKHTIVSRAHLTPEMALRLLTPQCSLWSAPPEENPFKDPYWAFYWPGGQASARYILDNKHLVKGRVVVDVGCGCGASAIAAAMGNARRAVANDIDPVAILASQLNAQLNGVAIDTSSEDLVGTVCSCDLVVVGDMLYDEEFADRLFSWLTRLARDGKLVLIGDPGRDGLTGERRSQLSLMRSYPLPKNICEENHGYTDANVWRLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INP7</accession>
    <name>A0A0N1INP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INP7"/>
    <dbReference type="InParanoid" id="A0A0N1INP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="78" mass="8965" checksum="96808653AA4369A5" modified="2015-12-09" version="1">MSSTHFHKEKTGNEHFDPKSLKSDLRPPCVVSLRRPPHLTQLTRTGIATDATRHKPSQHTASEKCARNHINWMRPIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP24</accession>
    <name>A0A0N1IP24_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP24"/>
    <dbReference type="STRING" id="76193.A0A0N1IP24"/>
    <dbReference type="InParanoid" id="A0A0N1IP24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF107">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="240" mass="28021" checksum="1F27AAA32C4AAF26" modified="2015-12-09" version="1">MVDSFVSDWSEYLTYDQIYNSTNYVPETPYSIQPSHSHSTIRYNDRDDTKVNVHSLRANDNSRNNQLLVGYSHDPYRYSIPEGDYIKGVRNIDPKAYTNKNESRGKRGVLHLYNMIFCATGCEPLAYKGYGCYCGFLGSGRPTDGIDNCCRLHDECYENIYCPFYTVYFQPYYWKCYHNQPLCALENYQTRHNFINGCAARLCECDRKFAMCVKKYSCPRGRALCHSSPLRLLQNLLMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPM0</accession>
    <name>A0A0N1IPM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein rolling stone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPM0"/>
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    <dbReference type="KEGG" id="pmac:106709309"/>
    <dbReference type="InParanoid" id="A0A0N1IPM0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="30789" checksum="A050BE092A857BBF" modified="2015-12-09" version="1">MTQLSWRQKAGCFFGALKPGDERPELFARSWLGLWAVYWRVPIFLWSLITITWSTAAFWGTTEKYMLYMTHWGLLLILVESLFGVIVALKEDGYVPDKKAEFPWYVKVYWVLYNITIPVAFLITVFYWSILNTVLRTFKKKVNYAPNPTLDVMLHGVNSLVMLTELILSAHPSRLRHVMQPLYFGIVYLIFTIVYYDAGGLDPWGHVFIYPVIDWSKPEQTLVVASLTGLFLALMHILTVGVATLRDMIARRCRSTPNGLYNDGFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPY9</accession>
    <name>A0A0N1IPY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein enabled</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_01352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ena/VASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460128">
        <property type="protein sequence ID" value="KPJ17574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPY9"/>
    <dbReference type="STRING" id="76193.A0A0N1IPY9"/>
    <dbReference type="InParanoid" id="A0A0N1IPY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000047">
        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="WH1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="307" mass="32873" checksum="749B5FCF26D05168" modified="2015-12-09" version="1">MVYDDHAKRWIPSGSSSGLSKVHIYHHTQHNTFRVVGRKLNDHEVVINCGIVRGLKYNQATATFHQWRDARQVYGLNFSCREDADSFARAMMHTLEILANKVTNNSAPPPAPPNPPAYNGHAHYDEDMGYRTMTREDAERGMHTHQTQVVGQSASVGNSAPPAPPPHAAAAAAHTLPHAPHPHHAPPGHHRTSRYTISPLIVPHQGADSSPPGAGAAGGAAGAGGAEHSGSSSSSGSGRAAGTLHCMMHEMARTLARRRAHLDKAEESSADNSATSTPLKTWERSATLPHRLPAACNGNTLLQNSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG50</accession>
    <name>A0A0N1PG50_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Connector enhancer of kinase suppressor of ras 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460557">
        <property type="protein sequence ID" value="KPJ13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG50"/>
    <dbReference type="STRING" id="76193.A0A0N1PG50"/>
    <dbReference type="InParanoid" id="A0A0N1PG50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="229" mass="24896" checksum="F2CEA83556D496C5" modified="2015-12-09" version="1">MGSLNIAEWSPDQVMDWLSGLGPTVAGYVPALRQRGLDGAKLLTLRCDDLEYLGIHIIGHQELLLEAVEHLRNFTLSSVAVRVLWLCAGVPVLQQYEVSRECVQQLALRVSGAATYTRIPHIIKETNETIKDYGSLEELYNLRRWAGTGVALGERKAALLKLALEAATCAQRDRFAEQPARAVAAAAAAAAQLADYIIQVPHAAAEPQPQPHAAAAAARTSGRPTHRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGP4</accession>
    <name>A0A0N1PGP4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA (Cytosine(34)-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGP4"/>
    <dbReference type="FunCoup" id="A0A0N1PGP4">
        <property type="interactions" value="2186"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGP4"/>
    <dbReference type="KEGG" id="pmac:106711911"/>
    <dbReference type="InParanoid" id="A0A0N1PGP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="560" mass="63850" checksum="1B312C6A07C2CF5C" modified="2015-12-09" version="1">MGRKNRNVNKFAQRKRDQKEKAKNPQDKPAADTRKHYEDIIRENAAFEEYYKTQKVCPEEEWSDFMSSLKENLPTAFRITGSKAEAAALLNIVKSEYFSQLLNVKIKNEEKGEEEEIKPVSLPWYPGGIAWQLRLSRTDIRRNEPLYKLHNFLVAETAAGGVSRQEAVSMIPPVVLKVEPHHKVLDMCAAPGSKTAQLIEFLHADEDKVPSGFVMANDVDNSRCYMLVHQAKRLNSPCILITNHDSALMPALVTTDNKDPTKTKPLKFDRILCDVPCSGDATLRKNPDIWLKWSTGNGNNLHGIRILPHHQDTGGFFVAVFEKTGLLPWEKTVEEKTEKETEVKEDKKEPPQKRRRMGGYREDPFVFFSGDDEDVFPSIKEYYDLKEDFDSKCLLTRCYVGKKKNIYLVSSIVKDVVQKNEANLKIINTGVKTFVRCDNKNMTCPFRLSQEGLQSILQYIGAVRRVNILKQDLILVLQNDNPSNPPDIKLFTEHTQNLVKDLATGSCVLQYQDTESNLKLTLVGWRGVHSLRAYTATPDTVHYLRLLGADYSKYGNTKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGQ8</accession>
    <name>A0A0N1PGQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGQ8"/>
    <dbReference type="InParanoid" id="A0A0N1PGQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32079" checksum="28C040E1CA516CFD" modified="2015-12-09" version="1">MFPAVIVCPEIAFPGNKIEEFIKNLDYPANYTEEYLRAHIQQLAAFFSPDVFYSLNDLEIIENILDYNNVDVETAGLSLTASCEECITRNLTDLESVPAPSNNKISKNFDFTDGLMIVVNQSQATPFDVDISYKWLSLHGSQRYVNLPENGTPITPGTELHARYIPNMLRVDYEAANIDRDQKRCRMSNEALEYFPVYRKQHCLMETEMRRTIELCGCLKLGHLRVPGVPVCRARSLQCARLASVSFGKFDSNCPVTCDADAMDYFTTSSYDLNTNISPNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGR1</accession>
    <name>A0A0N1PGR1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins. Required for ufmylation of Atg9; protects the nervous system during aging, possibly by stabilizing Atg9 and supporting its function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with Atg9; the interaction is transient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGR1"/>
    <dbReference type="FunCoup" id="A0A0N1PGR1">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGR1"/>
    <dbReference type="KEGG" id="pmac:106717679"/>
    <dbReference type="InParanoid" id="A0A0N1PGR1"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="294" mass="33527" checksum="D0DF5CA9FC95B6E9" modified="2015-12-09" version="1">MDPVFLTVAIISGLGLIIFTIAFLRKFQDRPQPRASKPTAVAPRDGGPSRVQAVRNQRARMRANAARHQAALIEEEPAAVEAAAVEEESSSNSQNVEFVDKMGAKKRAKVEAKMEKKKAKEAEDQMREMRKMEEQKIEEEKRKLDEQREEEERKAEEAERKAEEERKRREQEEYEAMKAAFTVEGEGYDENEEEDKDNMLKDFIDYIKAQKVVLLEDLAAHFKLKTQAAIDRITDLQATGELTGVIDDRGKFIYISQKELEDVAKFIKQRGRVSITDLAESSNDLINLNPVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH25</accession>
    <name>A0A0N1PH25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat protein soc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460195">
        <property type="protein sequence ID" value="KPJ17212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH25"/>
    <dbReference type="STRING" id="76193.A0A0N1PH25"/>
    <dbReference type="InParanoid" id="A0A0N1PH25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="357" mass="40462" checksum="5EEF84A0913B0D1E" modified="2015-12-09" version="1">MSAILKFIRENHILAVIEQAVAKKKSRLSLNAFEIAEIPNLLYTCLDVEHLYLHKNKISSLSVQLTQLSNLTTLTLDYNNLTSLPSEISNLKNLVNLNISYNPLNELIPEIGELENLEAFWCNRIGLREIPKEIGKLSKLDTFGARGNELKEIPEEMTALQKLRWLTLEYNQIETLPNTMDKMESLVHCNLRNNQIREFPMSIMKCPDLMFLQLNNNQISSMPENFDTSPLTMLEMIDIRSNPICDLPHQEYPLVRFTEEIIPNPQPSSSRTHATQALAVNATALRLPAVPAARHNDPLVIAEMELDASSIESSEDWENSVNSSELDVQYQSDEERAENEAIGMVLPELSRYASTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHW9</accession>
    <name>A0A0N1PHW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHW9"/>
    <dbReference type="InParanoid" id="A0A0N1PHW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="15221" checksum="1836A04E7A03D8AD" modified="2015-12-09" version="1">MSKSYIENDKNIANSKNEMIYNYKTLDDKINQQARNEKPLKYNTEDKERSDNAKKSHNKSYSSVQEEHGIGDDKLSSTSRNSSSDESEKLEVHRFDFTPIPGEDDDPDLHNKCWEYWKLIQNVRSSKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI80</accession>
    <name>A0A0N1PI80_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MAM domain-containing glycosylphosphatidylinositol anchor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI80"/>
    <dbReference type="STRING" id="76193.A0A0N1PI80"/>
    <dbReference type="InParanoid" id="A0A0N1PI80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051298">
        <property type="entry name" value="Heme_transport/Cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917:SF6">
        <property type="entry name" value="EG:8D8.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917">
        <property type="entry name" value="HEMOPEXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="417" mass="45315" checksum="6EB2C5B6FBFFBE16" modified="2015-12-09" version="1">MYITKIWFYALSSLLSLNSSEKQKYILFEKWGNQGNTWYDAVLPLVDFSDNFQIVIEGIRGSSFTSDIAVDDVAILQGKNCTAAQLDATTPSVLLSDSCVGRCDLLGTQKTGNGCSCTASCFAEETCCVDFFDTCIFSNDGDTNNDDNASNTTEIAPQTQKLIASSSETTSTTITTTTTTTPRTTSTERTTTTTSTTTTTAKPTTAKPTTAKPTTTKPTTTSTTSTTTTTKPNVTKVVDTGVVNKTNPINKSSTTQQSTTTTILPTTTVKTTSAKVQIDYSYTPIQDVFQDEVKKETNDEKIGEKEQHTIVYAKEPTKSGLKTSLISLLAILCCIGLVWLVLEVRSSRGRRTLARIRESGSLKTSLISLLAILCCIGLVWLVLEVRSSRGRRTLARIRGHITSDPEVRYLSTDVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIE5</accession>
    <name>A0A0N1PIE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040129">
        <property type="protein sequence ID" value="KPJ21349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIE5"/>
    <dbReference type="InParanoid" id="A0A0N1PIE5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="8184" checksum="C89C505F93768474" modified="2015-12-09" version="1">MGWPYCPQNGRPCGHKVLEWRPRTGRRSEGRPPARWTDDLVKVAGVSWMRVVKDRSSWRSLGETYAQQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIG6</accession>
    <name>A0A0N1PIG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050760">
        <property type="protein sequence ID" value="KPJ21493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIG6"/>
    <dbReference type="STRING" id="76193.A0A0N1PIG6"/>
    <dbReference type="InParanoid" id="A0A0N1PIG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14647" checksum="38D0E36ABDBF0DEF" modified="2015-12-09" version="1">MAEAMKESPNNTIDENELNSSTEKEGVEIFFFPDESNMKVKQQSSEAINLDTEPKSLEEEDNSLPVEEVLETKPPLIQSTKDVTDTSTPKSTPKKPKRKKVNTFKDSITIIIENNALYLFKTLFDVKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIW6</accession>
    <name>A0A0N1PIW6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_05582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIW6"/>
    <dbReference type="FunCoup" id="A0A0N1PIW6">
        <property type="interactions" value="1908"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIW6"/>
    <dbReference type="InParanoid" id="A0A0N1PIW6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="240"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="663"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="812"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ18403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="920" mass="102572" checksum="D71DFF1EEC353FD7" modified="2015-12-09" version="1">MSSFKRDKKEEEDSGGNPYQNLDKTIVLQEARYFNETPVNPRKCIYILSKILYLLNQGEKFTTKEATDVFFATTKLFQSKNVMLRRMVYLCIKELSTMAQDIIIVTSSLTKDMTGKEDLYRPAAIRALCSITDSTMLQAIERYMKQAIVDKNPAVSSAALVSALHLSSSAPDLVRRWVNEAQEAMNSDDPMVCYHALGLVAGLKKNDKLSTVKLITRYFGTSVKSPYMLCLLIRFAAQMEAMNSDDPMVCYHALGLVAGLKKNDKLSTVKLITRYFGTSVKSPYMLCLLIRFAAQMVETDDSDTSKRFIDFIEYCLRHKSEMVIYEAAHAIVNLKKPVRDLAPAVSVLQLFCGSSKASLRLAGARTLACLTAKRPTAVAACTVDLENLISDPNRSVATLAVTTLLATGAESSIDRLMKQISSFVSEISDEFKIIVVKAIRRLCTKFPRKHQSIVAFLAGMLRDEGGLEFKAAIADAIIEIVEENPDAKETGLAHLCEFIEDCEHSALAVRILHLLGREGPKSRQPSRYIRFIYNRVILESGPVRAAAVSAVAQFGAQRPEMLPNIKVLLSRCELDDEDEVRDRAIFYNAVLDTGDQQLINDYIINVVKLNPIQLEKALREHIATKPDETFDIMSVPTEELNEDKEDIVEVEVKKPTQMSTEEMYNEMLSQIPGIERLGPIFKRAQVVELTEPETEYTVRLYKHTFARHIILQFECVNTLNDQQLEQVHVRLETPPEYNLLSIVPCQKLVFNKPDSVFVVVEFPSAYLDSLGTFGATLEFVVRDCDPNTGNPDPGEGYADSYPLEEFDINCADQIKTRTAAEDFEETWECAANSPEASDTFALPYNDIEEAGKAVCRHLALPNEAVSGDAIKEIKGCGIFRGGAPVLMKAKLVAINVGVTMKLAVRSPREDIAQLLLSAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ13</accession>
    <name>A0A0N1PJ13_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ13"/>
    <dbReference type="KEGG" id="pmac:106720872"/>
    <dbReference type="InParanoid" id="A0A0N1PJ13"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="443" mass="51133" checksum="7F00CE89597752E5" modified="2015-12-09" version="1">MSDLAGEWDRRKTYLTRCLFEDLPLLSPIPERREPDQSETNDLCSALPDLIIEKEKNRHDEPEEFYQELEKKMLRLYRKLFLCHHEDGSFLSINSTSSYDVTELIEDEIRQDSDNEVSNKIPFDGTVFTPGDESTRISDGGTDKEPMYSLPQDCLIQSDDECSEEPRHEIITIEAMIHTGEDSQRNRKRVNEEISYSMAAQSPIIGCKHVQQINEDWDEQTSDRRLSTQDATFASSNSPLLVSRVSFLDENEARLVAKQAITQKYSKSTSHDFEVYDFSPIEVMRQKRNEDSNSSIPEVRHNRRSSMEPEFVKNLNENEASPVKMTQTYIEEEMASDVVRSDRVSQILGEGDLRNNTLRDLTTISSPVLETISRKRLRSDSWDASQELPKKRMKYKDIGLQTTIKESFSNVTQPCCEQPPTNYFYGTPMILNICRCKDHTCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL35</accession>
    <name>A0A194QL35_PAPMA</name>
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        <recommendedName>
            <fullName evidence="6">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14541</name>
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    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QL35"/>
    <dbReference type="KEGG" id="pmac:106720310"/>
    <dbReference type="InParanoid" id="A0A194QL35"/>
    <dbReference type="OrthoDB" id="10068079at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF3">
        <property type="entry name" value="TENECTIN ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264454" description="VWFC domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="2973"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="6">
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            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
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            <end position="378"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="2973" mass="328298" checksum="17ED29D6361FDAB3" modified="2016-10-05" version="1">MEGRRAAALLALAACVACSHAAPTASNQTALDLYEGAPEGCYYNFQHYGEGDRIMTNEPCLNCTCHNRMLMCYLRVCPFTKPIGQDCTVEKRADQCCPIVTCPDVPVDLLTSTSTSSPAEYGATGVGHQDKYGCSINGRYFPEGSKVPPTPNKPCEHCYCIRNMTTCVMQECTLHVDGCVPIYHKDVCCPVRYSCDHPEDDIKLLDDMTTTVRPTPGFFLTTTTLSPVTQVSQDCVHDDQIFADGALIKTEKACEHCYCMKGDIVCVVQECGTPMENEGKNCTSLPPRQGQCCPDTYICEGDELTTEHMPELTTEEILKSTSVTPPKKGIEGSGYRNEPDEPYTDLPIFETVEMEGSGEDQSTLSIGQSESVTPEKPTPDFADEMLLTTIKQFESQPTSATEIDIGTMVTKSDKLNTEITPSHETEYDIVTESTKSDGEEESKTDSLNQVTETTHIDSHDNKVTEKPLLTTLSDFISSTLGESLIPVEDKSDKTTESSFRKEDDLSAVPEVTTKQTYDGLITEGEYNEPKETKEDMVPTTATSIISGEEDDKKLHTTTEIVMTADIDKEVKEKVETYSSTTTMRSDTLETTNPTENEIDEEILPILSPGRIPGEGDCLLNGITYKNTTDVPSTNKCHTGCRCVSSIIKCDPIICSPPPEYANMNNCEPIYDSAESCCPTYICDHSIEGTLPESHSQMSGTESPKPVKNNECIGDECLTDEHTISPTQSEKRPGQPECGKEGCIDTVPVVSEYPDKCDKETGCQVTAVTPCEGDNCKDFITPEPDTHISSPDNQDDTIEKECHNESCRRKEISQDTIKLPSPCVGTQCETDTQTDVITSELTSEIPIVSEEATKTSHVPTTITPESQTFRTEEQLTTLGDESTSKYDSTSRKIDVEKQELTTESIQHIDEVSDTGMTRGPETYITEHPKVTGVVDDSFAGDLDSTTIADTEEEHLTTSSHDLEAPEPTISEEKPELEQPVSDLSKDFTTMPQTSAVEESQGITMSEKEEKLTTTSLESASPSSQTEKESDQDESTEPIDVHYETTPVLGGDLTTKETYATESAIIKEENDQQYSEKLSTVQDSDYTTETSKLTKADDGTTPEIIKEYSTSSPQSQGNDETTPEIIREYSTSSPQSQSVEEKTTETAIDSTEKAISNLLDESPANVAKDGSTTTVSDIIITTAGHEFVTESFKEPEKDIQPTDQSSEHSIEGESTQKYDKTPADQYDMSSVASESDKYDKDQQITPEAVYTTENPIFGIKETAREEPSTELSVTDNVVINEITHPSQQDVIESLNGRATEGPDVYEHDGLQTMAQDADLYTTVLTESAVTSSDEKHLETVSTEKTTEKSFEQDIETKKPTQLESGTVKVVTESVTTEPERGDGISEDDNLVDDMDKMLTTNVLLNEITTVKIDATEQTLKEEAEDHKEETINEVSPTVEHMSSTETIKDSTEVNTETYLVTSSEKHDAQSYSTETLSLVTERTVPERHELEVTPTSSYPSEKETSEDSEGSGEINKQQDDREEQHTSIPTKMSEEITTEKQDVPSSITTTLPDISENILHTTLLEEHIATESPSSQVTENIVQESLPTRRVVDQGTEVTVSLEEETTTKSSGLTETITESPDLTTKANEMPDGEEEKVTIPSHATVFNEEDKTTKIDLISEEEFKEKTTIMPETVTSEQLFTNAETQKDSEITIIEQTKLTEVPEKSTSKSTVTELEAVTEKLFTSDLIKTTEEPEKTTAGQYYTESIIENVTAEDKDESTGFPNVVTPSKLETETPELTQTVQDISIQDRTTVIPDLLVTEHIHTDLEKTTFKAPEMNIDLDENTVNIEDADRTEVTDFPIKATETYETHEQTPEKLATTQQEPLLYETSSPDMLYAEKTTESAEKIRYPEHISTESSEPTDVSAGHEDGLSSDKTQEEVTLPDMITESVIITTESSNVEENMKDTETRDEKTTEQPLIDTENAEKEIDFATGKPLIQDHVTEKQPEANVFEEKATEKPFINVDDVEKDVDLVTDTPMILEHVTEKETGSHIFDEKIPETPIKVDDAEKELDFTTDKHVILEHVTEALPETHVSGYPRITTLAEQTPTEQVVTEMPEFVDSQQDTTTVKPEKSTLESATVIPEHKGTGTTVLSEVETSSYLPDKSIVTEEGTTISDEKSPETESKPVESTVVTELPELLTTSKSAEDFDKVDVTAATESTISQGGSKTTPILDTVPSLISQETDSEKPTTDEPHIFSTISSSEEKLEGTTLKTIHEKTTEIIEPSTVGETSIKTESPETTSERELDAVKINIDGEDKTVAYTTEQYTEMPEQILTDIHKSPSQSSESDTTITEISDIVTHSPEKHTTNIEEEQTFTHEKHEHLTTIAESLMTQQVETETVLPTTLSTERTTQGIETSEHLTEAQLDASKAPELSKYTTESGDIATPTLMEHTVNEETVQTELPVTSMTPRDEDTHHEVISETKETKPDYYTTEKIEMSTKSNIESDIPVATESSILESRPSSESPAHPQHTEETSEKIDEHSESTPYFVELEEHTHKGIEETAPEVYHEDITSTIKPEILYPGKLHDELTTEKQETEESLEITTEKQNIDESLKITTEKQETDESTKKETVETSTSAVSQIDLGTPEILHEISTELPTNDDKITTLSPKPTEIETDVSKLSTVSNDKDRTTSIPVVTTPSYEEAETPKQEDHATTIEKEKETIPVKPTDVIPSSQETTALEEEFIPAVTQGTTGKTMEDITTLSPTQSHKFTEPKEKPMESLPSTSAPELQKPGFNDMLPTDEIPPTDEDSHFPPTGSSGYGQEPDYGEEDQAFGPGTCRYGGKVYVSAQQIPRDDPCDFCFCFRSDIICLQQSCPPPIHGCHEEPIQGFCCPRYECPVSMATTLNITTTTTTTTTTLPPHFLPHAYKGAAQRRGCQIKGHTYKVGEVVRASSGPCLHCTCGGDGQMKCDPKACTPEPMLRQMIAAAVSAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL48</accession>
    <name>A0A194QL48_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL48"/>
    <dbReference type="FunCoup" id="A0A194QL48">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QL48"/>
    <dbReference type="InParanoid" id="A0A194QL48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14513">
        <property type="entry name" value="DSP_slingshot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="345"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="407"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="939" mass="104962" checksum="7CEE4240E3DEE2EB" modified="2016-10-05" version="1">MPVGVVECLLNGYIACCSLNECYFANKGAALVLGGAESGCAERRRLPAPPPQPDIHHHLRAMFYLVRPEDTLKMAVKLESAHAGRTRYLVVVCRHDEAALLGIDCNDRTTVGLVLRVLADTSIKLDGDGGFSVCVCSQQHIFKPVSVQAMWSALQTLHRASGRARELNHFAGGASHAWCAYYETRVDSDRSCLNEWHAMDCLESRRPPSPDSLRHKSALQTLHRASGRARELNHFAGGASHAWCAYYETRVDSDRSCLNEWHAMDCLESRRPPSPDSLRHKPRERDETERVIRCTLKEIMMSVDLDEVTSKAIRGRLEDELDMDLAEYKSFIDQEMLTILGQMDAPTEIFDHVYLGSEWNASNLEELQRNGVRHILNVTREIDNFFPGMFDYLNIRVYDDDKTDLLKHWDNTFKYINKARNEGSKVLVHCKMGISRSASVVIAYAMKAFNWNFDKALKHVKAKRNCIKPNTNFLNQLETYQGILDAMKNKEKLQRSKSETNLKSPKTASKTENKITDPTPFILALTGSYSGRPRSWSPDTKLASELLPPTSVSLENLAAETRHMLMPCAHGSYSVSPNQIIRLKEEKESGLSVKHIVNEIENAASGDRRDVARRHQRLNFGNHTDVSSGRSSEVSIGLSAQVADAPTKQSQVSPSRHLGHKYTYSEAEADKIHTWDPGEAPWSRGDEIRNGNDSDNIVKSDSGIIDVKIKTSDAYVNCIDRNIECDDRRTMEEDAPPPSRQSSWSSFDSAVVPDLSRHSSWGSYDTRTARPQVVVRDDSAKRVKDRADERSERSAEPAPAAKQASDLGIITEHSEPKVPRRVDISANERKFNETCAILKELANAAARMERARDRGAPALRGAEGSWTRGAQLLLRRRATGARDAAPRAPRTPRTRCAVAGAGRLLECGGLNCDVESSKQKTIATWENPSLDEAQLEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL78</accession>
    <name>A0A194QL78_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL78"/>
    <dbReference type="FunCoup" id="A0A194QL78">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QL78"/>
    <dbReference type="InParanoid" id="A0A194QL78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="371" mass="41517" checksum="224F678653E92A21" modified="2016-10-05" version="1">MNIPLLSVNDLFKENISTITAADIPECGRHSDEESRVKFFSLEEIINSIGEMSTKAQGLKRIITTLEKLCLSPNHKLYILKDEKGNGQLQHADKIRASQPLCFKTLIIIIIISSLYVPTEGLGAYPKGDGEVIGILKIGEKKLFLYDRQGKLMISTPMCVLDFFVLDNRQRSGFGKKLFDYMLQDQKLKPYELAIDGPSPKMLDFLKKHYNFTKVIKQSNNFAVCEKFFESANMGTNRPQEQIAAISHTNFKNWDSEVGSVIHGGSSSSSNLSHKSNESEASISEADGETSEERWEVAAPPPAPKQESHDPSADTKISSKPPERPSTLTFECCNVVETEATVELSKTSDYSDSQLTDQGYVDLKFHHIKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLJ1</accession>
    <name>A0A194QLJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Troponin C, isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLJ1"/>
    <dbReference type="STRING" id="76193.A0A194QLJ1"/>
    <dbReference type="InParanoid" id="A0A194QLJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="584"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="660"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="694" mass="79047" checksum="2616044E6424FED8" modified="2016-10-05" version="1">MAFRGVITRPPSNNNRCKADSCRVVCYNAPYYNSYEEDIINTAIDTEPNCEIIFLTLKNPMFVNSTLPLNWLSSLRSKIGSLAIIGGNLKHIAPNAFINTFATNVRTLSLEDVTLTNWYPETFIGLSNIEELFIKNTKLLTIHSGALKTIDDTLTTLDIKATNVWDPINITGSANPDKLTTVDFSKNIFKHILNKNSFSRLQNCKILYLNSCKISVIANGTFDHLINIEILFLNNNFIHTVPDGLFSQILTLKHKPRINLQDNPWRCECTTNELRKLHVHDLLIVEPSCYYPKEVQGLTFSEFENYCLSNDSQTQVIIPDINDYKNFNRSYQTLNIENKLSCDYDSDVGYEITPLISTSNEYRCTGFRAQNYKLIPTVSNSLCDLFSTDNKWLKPVFYSRSEPHSVIEISSQGPSNHGLLWYRANCPREIYCVSSLPQVLRIFNVNKNNNYIFCRFYNRTVLTDECVVYDFSKSDQSYRRKPIFLLCMVTAIVCLSLGALVVYGLIRKNPGLLKGSKRVLFVKHKQVDALVLPPKVPLRSNQMKETHFSKRVLKKTFEAFDQEKKGCIGTVMVGTILGMLGHQVSDESLQEIITEVDVDGSGELEFEEFVTLASRFMVEEDAEAMQQELKEAFRLYDKEGNGYITTTVLREILRELDDKISAEELDMMIEEIDSDGSGTVDFDEFMEVMTGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLS9</accession>
    <name>A0A194QLS9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLS9"/>
    <dbReference type="InParanoid" id="A0A194QLS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027905">
        <property type="entry name" value="CFAP95"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15139">
        <property type="entry name" value="CFAP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="23558" checksum="9B3A462BFCA2A7EA" modified="2016-10-05" version="1">MAKKPPQILFCKNKYSPNVKVENWDLVVRAEKKDNYVYRDQLSNHLSTYLRLGSHDQGVGPTETGHMLQQVFMRKDPVYIYKPLVNFTSYPCTDTPGRNRLMKTAGLAQLPPDFGIMDYLSTQQDDYRNPHPTVLKPITMPSPIWLMNRVIRSQLTQNYGTAPPRGDYQCLDTHTPIDHIRKMRLKRYQSFDPASGLQDFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN33</accession>
    <name>A0A194QN33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Down syndrome cell adhesion molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="interactions" value="90"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264496" evidence="1">
        <location>
            <begin position="26"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="32585" checksum="535ACE4F1CAA8086" modified="2016-10-05" version="1">MGQGVSGVKTTIWLYLLHGFVFFTADSGTESPLDTSTMDISSRRFRAEFLQEWHEAADAPYFDPNTPRNITGLVGHPVRLLCRVKNLQNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAQHKPRSEEWALRIRSPQRRDSGQYECQISTTPPIGHAVFLNIVELFIQAGSTINLTCIVKHTPEPPSSITWTHGEQVINFDSARGGISLVTEKGLRSTSRLLVQQARGADAGVYTCGPNNAPPASTRVHVLSGEHPAAMQQSSAKCSVDKTILIFYLSSMLYIIGPFNVLRFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNM2</accession>
    <name>A0A194QNM2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pulmonary surfactant-associated protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pulmonary surfactant-associated proteolipid SPL(Phe)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_11453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pulmonary surfactant-associated protein B"/>
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        <property type="entry name" value="BCDNA.GH08312"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0767">Surface film</keyword>
    <feature type="domain" description="Saposin B-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="13">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="512"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ06954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="573" mass="63612" checksum="22834BB09B74F0E8" modified="2016-10-05" version="1">MNSACRDVPVPTITKYCREHTAHLEEYLLALLTSQTSPETMCSVVAMCNSDKLDNVLSMIKKKTTTPKTPTDKYGGKLLGASKCTWGPSYWCSNFSTGRECKATHHCVSRVWPRAEYPQDSDSICKICTDMVKQARDQLQSNETQEELKEVFEGSCQLIPIKLVRKECIVLADDFVPELVETLASEMNPQTVCSVAGLCNSARIDLMLEDYMCGQMGSFSDSCSMLVFKYYENILAGVKKDLTPTGICHLSGQCAVRYHSHDQYDFPDVKIDQLKATDDVPCEFCEQVVKHLRDVLVANTTESEFHRVLVGLCKQTGSFKKECLSLVEEYYPMIYNFLVSELKADAVCAMMGICHNNSDVPVAVLLPKELAVKVTQSPLLIGNDEANSYTTPKLARVSLKKETNVRIMVGEQSAQDAQLPIERMYVAAPQNKAACSFCQYFLHYLQVELSDVNNEDTIKDAVEKACDKLPDSVNGECKQFVTEYGPAVIALLVQEIDPASVCPALGLCPQTEEVRRVAINSDKSNCPLCLFAVEQLETMLKSNRSEVTNQQFTSSSTGAAIAVTSIRKYVKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNN3</accession>
    <name>A0A194QNN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein spire</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KPJ07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNN3"/>
    <dbReference type="InParanoid" id="A0A194QNN3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament network formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament polymerization"/>
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    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cleavage furrow formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spire"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="58077" checksum="080DCB93B269EBF6" modified="2016-10-05" version="1">MGVCITSTLAMEISHIFKNGTFEVVPIVFRRVHEIAACLQSQTCFERARQCHTSSKLRRSRVSPAALLLGTRPVSGLLEPVRSPEEPALDVAQDKAFWGSVAATMTCNYRTQTSNGASSGPGSVEVRRNGGGGGDVTPHAPPQRRLIKVDFDNLEDDEDEDDTETCISPETCIPQPFPRHTAPQQPAPKPWKRTAYDLATQCPSRRASMRRHTVTHVCPPSDGAQSLPHSRPGSRASCAGAASLASSELDAQLGELSWSRSSLQDELIKSVSGSPSSKHKQWQEAIMSDDRLSLTLEEIVHIRSVLTKAELEFLPSEGRVKEDVEKRRVCFLCLKTRFGIFGPWGQKCKLCKKTVCQKCCSKMRIPTEHFAHVPVVLLSPSLLPSPEDEAPSFPRSLVSRLVSPEHHDNSVGSAPSSPVSRRACPQSAPGSRGGSRGGSALGFADLAVHAPSAMTRSVDGPGSMPCVINDRRSRGGRGSGGASAAERLRGVQMAVCHDCKAMVLQIIKSSRAARSASRDRALRHLTLDLAPVYTDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNX4</accession>
    <name>A0A194QNX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating Rap/Ran-GAP domain-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNX4"/>
    <dbReference type="InParanoid" id="A0A194QNX4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="181"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="479"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="944" mass="104784" checksum="D82654E9A81E8C1C" modified="2016-10-05" version="1">MRHRGHTEGVSCLSNYLFGLDYFDQFTYALRKEKLSASVEGGGAVDAIVRRYRLENGNSLGEKDELFGPPSAPVLENPEFQTRWYFKYFLGKMHQNYIGVDGAREPYLLSVVQEGAGLLRAILFNKMGAHKIYLPASAWSGGGGQTPTRPTVKQILAQFTAMERVDKVPREITCPELQKDILLLEEQEGSVNFKIGIMLMRPGQRTDDEMLSNEKGNEKWERFISLLGDKIRLRGWNRFRGGLDVKGDMTGSHSIYTMHQGHEIMFHVSTMLPFSKDNKQQLERKRHIGNDIVNIIFTEDSTHNTFNPQYVKSHFTHIFAVVSEVDGEGYRLSVYSDDSVPPFGPSLPCPPVFNDPQLFREFLLVKLMNGEKAAFQTPTFALKRQRTLDTLIRDIYAEHCSDHKVPMLSRRALSDVWSGGAGAGGAGAARTERFLHVGQALKLDAVLRGDAPTSLVSTGSGGSRRAPWEGRVWRAAPLPATPVCAEQLSEGRLLLSTTSNTYILEESGTTRVVLRWEGCVRAARVTDRVGLFRVGPRVVAGGGSTTGGAGGAGLYALPLPELCAGAWAMRPLQDCKHARLPRTKTAHYFDVIENVDGGKTLLAVAIGRRVILLLEEQKTENEMGFEYTHIKDIQLNESPILIKLMDGEVPVVVVGYKHHWEVLETTTGQAIKRAEGSEDSGPRRGALVNALRIGDERDGQIILCYNHTCHFERITSKGLESDSEYDFHWTTVPTAVVCAFPYIMAFAEDLLEIRLVANGSLVHAACIPGLKLLCGRRRSLQDIFYVACAPEYVPLGRELDPGLHDTYDLLRHITRQPNTYSVDDDDADKSDQGQNNRTSEDNSASSRSSSVSSEQENIRPPLQRMAPVSPPTSPQVLPENSGRCVRIYKIPQSNLSAGAYQRQSVSADQVVTSYFSDRPNSIKQRLAELRLDSKSRGGGEDDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP14</accession>
    <name>A0A194QP14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear receptor coactivator 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP14"/>
    <dbReference type="InParanoid" id="A0A194QP14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="302" mass="34200" checksum="6DB90FEF5A70AD19" modified="2016-10-05" version="1">MKNRATAHLRIYVGGITERATLEELYEHFSPFGQITGLIFNRSFGFVQFENEASAQEAIAKGDGSIFQGKSLCVRAALADRQRRETDFTPASNIENTSSNDNYTPKEGNNEQSKSNNYSNYGDQRQSSTDYREEETDEAYGKGYGEGYDANEPRGQREVRESREQREVRESREPRESREPRGGMRGRGGPRGRGKARGSVPSYRDRTPVNPRGGEWPERSSFERYPPPDYTRTLPITERNDCEIIVVSKALTEYAEYIESRLKRLGIVVDLLFPMEDVPIGKVLGNIASRGCLYAILVMPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPK0</accession>
    <name>A0A194QPK0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPK0"/>
    <dbReference type="STRING" id="76193.A0A194QPK0"/>
    <dbReference type="InParanoid" id="A0A194QPK0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="462" mass="50281" checksum="CA03DE1FB2649DB6" modified="2016-10-05" version="1">MLCQEMPGYGCYKFKREPASEGDDSSSQSAHDIFYHQRVLMLQATPLPAAVKVEATEQDASSQILHHLQVGVGLELCPPAPAAPAATPVHARRTPHDTPASPRSPHAAHCFETLEPARAHTGTTLLDRHLRLIADAAEPDLMPLLSVKDEPLSEGEQQMLSDEASSCGGSSEGAEARGGDSPPGPRAWGPRDMQRALQALRDRRMTLTKASATYGIPSTTLWQRARRLGIDTPKRETTARSWGEAELLAALAALRAGTLSANKASKAYGIPSSTLYKIARREGIRLAAPFNAAPTRWRRGDLQRALAAIRCGAASVQRAAAQYGIPSGTLYGRCKREGIELSRANPTPWSEHAMGEALEAVRVGQMSINQAAIHYNLPYSSLYGRFKRCKYQSQCLQYQQSDTRNNYEADQEMQTRQESLAQEQVEVPYSQLVGEAHGVLAHWQDCAPGLLHAHGCSGLAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ49</accession>
    <name>A0A194QQ49_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ49"/>
    <dbReference type="InParanoid" id="A0A194QQ49"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="11339" checksum="5D868AC964736433" modified="2016-10-05" version="1">MKISHLSSLNHSLQQSATTMWERDLLFMLYENRISEGCSCIRFTSTYGKERGTFSSPDYPRPYPAHINCLLYTFIAGPHQIVELVFTDFDIYKEHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQC5</accession>
    <name>A0A194QQC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQC5"/>
    <dbReference type="FunCoup" id="A0A194QQC5">
        <property type="interactions" value="2067"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQC5"/>
    <dbReference type="KEGG" id="pmac:106718729"/>
    <dbReference type="InParanoid" id="A0A194QQC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="277"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="44667" checksum="F79D3D9D7CE25622" modified="2016-10-05" version="1">MAGNSEADTKKPMSDTERLELCQKLDQELDDFINSLERKRYTEGWPEDRWEEEMDKHPFFMKSNPDGDEMSPLAEGLAKLKYDPEENTPMVLANNYKEDGNFNFKHKNYRLAILGYTEGIKVKCDDPEINASLYNNRAASHWHLKNYRSALYDSEKALSFNPEHTKARLRAAKSACQIAKYDVCIQHCEKLLSQSNDKEVVELLSIAKKKKLIQERDERKEKRRTNKKEEERDAIVKMIIERGIRVSNCDDEDDIDLSKLEPCLPDSQDCMVHIENGVLKWPVLIMYPEYQMTDVVKSCPENVPLLNQLEQLFPAPWDTNNKYNISTVNIYFEGYDKMPHVIDPKKNLGDLLVMKYFELKAGTPAFFILPRGSVIESRFLESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQG2</accession>
    <name>A0A194QQG2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQG2"/>
    <dbReference type="InParanoid" id="A0A194QQG2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="366" mass="43181" checksum="25876A648DE482FB" modified="2016-10-05" version="1">MLIEREQDTSEYWRETEILTLVRHDEEGIDYEKCEQNAPEVSALRLPARRTVRPICRTAYELIFINLLSTIFQFWILMSKDPRFCVFWCLLFRERTVMPSEYRTYCDQKYGKWHTMFLPADYSQCRCCDERRSFRYELPTVEECPVSCRGYDCQSLVHEDQCPQGAFLPDKDYCNCCGRCSTFFQLNQKCAEFKKTIHKLNESEEIEIEEEFLEPGCDDGLVCRQGICQDTHTLMSRSMQRLKREQLPFGALEPCKQEMKYFKKKYGVNGHLHHEAPQCTPLWLYAPVQCRRFVCYCALEDGSRIEGIKVPRVEVSNMNCDCAREKCRTASDLECDGYGNYKEAVFMPHVEQWPEQEEVYESGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQN1</accession>
    <name>A0A194QQN1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
            <ecNumber evidence="4">3.1.3.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Inositol polyphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">RR48_12649</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Ya'a_city_454_Pm</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83420"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57627"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:77144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77155"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:77156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:25018"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EC" id="3.1.3.67" evidence="4"/>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQN1"/>
    <dbReference type="STRING" id="76193.A0A194QQN1"/>
    <dbReference type="InParanoid" id="A0A194QQN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
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        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
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        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="24">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="23">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="25">
        <location>
            <begin position="156"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KPJ07807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="354" mass="39551" checksum="5022C47EB33F3ACC" modified="2016-10-05" version="1">MGFPAEKLEGVYRNHIDEVYRFLEQMHKGHYKIYNLCSERSYDKSKFHDRVVRYAFEDHAPPKIALIQPFCEDVHKWLSQDPRNVAVVHCKAGKGRTGTMVCCYLLYSGQKATADEALKFYGTERTYDEKGVTIPSQRRYVEYYAALVRSGLQYSATKLHVRELLLSPPPALNGAQCTLELSATQLDPPFKTSLGSQEVRKAASCVRVPVAHCTPLRGDVRLELHWKPKMMRRDKLFHFWINTFFVAAAVGAVRVPPPDDTAVILSFSDTETDGHWDSGETPPPPGLAPCAPEGLAPEGLAAPGAKLPKVCSDHAIADSVTAARPRLSLGDVRASWRGLTKFSDSRKKKHRDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR03</accession>
    <name>A0A194QR03_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR03"/>
    <dbReference type="KEGG" id="pmac:106720278"/>
    <dbReference type="InParanoid" id="A0A194QR03"/>
    <dbReference type="OrthoDB" id="7457990at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ05961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11038" checksum="F11D3CF4A659576F" modified="2016-10-05" version="1">MAPRDTQTHREPTKGVNIVKKKPVKTNKIEVAEAKPKTAPAPKPVTPKSCKKENKQANVTGSVTKSAKKPMRNRRPKPAHSGVPVPEKMRKRLAQLLNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR65</accession>
    <name>A0A194QR65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM and SH3 domain-containing protein 3</fullName>
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        <name evidence="6" type="ORF">RR48_14468</name>
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    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR65"/>
    <dbReference type="FunCoup" id="A0A194QR65">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR65"/>
    <dbReference type="InParanoid" id="A0A194QR65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="537"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="619"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="839" mass="92812" checksum="34A6A9FAF79BFF8E" modified="2016-10-05" version="1">MSPRMRVLGGPGTPQTPPSASPGSLALNNLTTSHSQPIYVPGKYSPSSCLTDKEEDEIYGFGYGVFGKHMLQRQQQQKQLLLAQPNQPLIHNQQHNYQSCLSPRSAYFYEFPPSDNCLGTAKKKVTTFSRLLRGLKSHRKEKHGSCSPKHSHSPRQVLPPQRVDTPDSVLQSGLGLGPGPDTALRSMVDPRDYDRLRFFQMNAAQPNTFEETIHRLKVQEAMKKKDKLAREQEEILRDIRHGLMNMGRDGVRGPFGGYIEYSFTDDTYMYDDEARGLSGRGHWYDEPPYESDPEDFLMGAGAPAASFQNGRVCFTLNLRNESRGEGVISLRSAGDISLARTPRRGLIIPQSGPYPTTVIPLHTARDRESGDYAASDIQSIGSRLSGISLESSRSERDNRRGYRQMSGYRIGIDPLSPASSDYEDQESETDSQHIATVHKSADECEGVSNLAGKVRGLRQDVQRKISRLRQERGPDTIDRRTSGDQAFPCSNSSFESLPSGSGSSTQALVRAGSNHSSLSAEENIELSPAGRSLLVPQMLCRARALVDYVPNIYEKDALRYKKGDIIEVINMNASGIWRGVLNNKVGNFKFANVEVLSDRDTMRSRSSKWCKSRERLWETRPRTVEELLKRIDLPEYTLAFARNGYEDIELFKEIEPSDLDYLGIMTPEHRTRILAAVQLLHQLECGEADGEGEGGGSSSEGGDSPFGRRQFPRDSGCYEASVGVGVGGVRVRTSPLVHRVDEPSHRPPEPAPQAKRSIRRRQPDEAECDRIERYPGSGAERSVVRGGGLPGGSRDDTCETDHKLNVVKFVAGGEPCASEKSSDSGVSSSSLSSAHPHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRJ7</accession>
    <name>A0A194QRJ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spatacsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QRJ7">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRJ7"/>
    <dbReference type="KEGG" id="pmac:106720361"/>
    <dbReference type="InParanoid" id="A0A194QRJ7"/>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008088">
        <property type="term" value="P:axo-dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1918"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1939" mass="223564" checksum="91ED8D8712FEA65B" modified="2016-10-05" version="1">MEGLTQNEKIIWSCWEEKSPRDVVREAAAKGTHIDLAIQYLMQKNSWNESSSREWFLAEVKAWTVQLLLRKQIFKVLHVLNKVNINPEEHLMTLAATSSNIEYRDFIVEHLEKLSKDIKSENLDKWLNFKRHWNLLRYLEKSFEVDGTFKQNKVFGEGNDRVFVNESEIKALTIEEIEKYPSHWKSKIATTLFFNTFEYSLLDFSSPQQMWMHLLEHNKAMVLVRWINVQTSEVVRDMNARYNFFINENFVSKLLNVDTKGFSSEVLTNLDKIFRSWPITNEMIQSVAASNCFVYTKLCIYDTLCSYGIVNDEERKNLYVIISRLARTQNLKQIDDIFTESCATITKQEFYVELAKYCVKNKLYNVLTMCVEGHILDTDLSEVEQEAKDCIELWLLFKSIEQTSDRQSHVVPVYKTCQQIAKDNIDNYISTNPHLVLGMILLEDDANLFDIFSKLDNLQFKDFKLPNKGYKHKLPHLYNVYKKFAGGYQMYDSRDVNVYQLLSGYRGLDVSKIFEFQLINQNMKSILAEKSDRRSLGSLLSSDVDVTGGIKTLTQRSVDMPDFENEKLIKRYGYVAKLNHVYYLKQYRPCNASQAFVAQQYQTYNRLQEKSIKSACCEAHALALQNWSDPAMAACAVSFVAMIGCNPSRCRVHMSAAKMIKEHLMVNKNFSEEKANKVVNEYMSKLMQSNDQAAKEILLYLEEITINKLKHMQSEDKFDMTLVLYESQTMVKFAILHNLQLPELQLKEFVRNNSWFNFLLFGDVFRYPLSQMLQLSQDFEKQSYAEHLKYIMLHKTTEEDKDYKSVSSNGQRRFSRLNSMEVSPTQNLSFEFPLSWYMGRELWEVAAACHGPEDPPAALLRAADICREPLLVLIASCYEPNAVDVLWAQWVLASIGLSEPNREELQAKISHRPLSEQFLVVAEVCLVEGYIATLQESMLVFMSDSPLTLLTTFLHRCIRLCTFDMETSRTLGNFLQQCQRKYSSESAGLPWHMSKEMLQKIAVELVKIALSYSFDSAYHQREFLRCLSEAQFEKGLMVPTPNFKTLFEIIQISMQTSLVVNIQKLLRDDCENYLAECIKMYTENRNYDVALKIAKLAALPVNDILQVEWAHKYEMLHMRETEIEDKDLTMFIAECSEAFKKASVTFTAATDFLTRHAASITDPIQKFYSYRIIMTWFEENHEYGKRREEIEHSMWHAYFSVENQDNVFLNSYQCLLHFVLTGQKDKTLSQSMGQMNSDKFSVTLHQIEVESDVGNIEDVVLLEEPETIDCWRRVVNQLLELRLLVEAFRLSGLYETPPEYLYRTPACPVQIIRTCLRLAEGACSPYELPQELRLDISSPLLNKLTLSETSETSFEELVVIQERQESGAVPHLAAREDADRLAALDALAVRSGLALAKQIASYFRIALQIGREYMFVLKYECSPVDFINLVSGRARMSLANLVFRTFNVPSKQVAEYLCLEMVGAIISPHLVKTSTFRQKEHFQYTLWGFVLNSDIEMFLNMRPDACSHIGRLILDHLIAFQKIYKATTTFKIPENTLDDSCLDLETLIDEEYQHVDNDEVESVLTEEGTLLSAETESVYSVSTVYTVGNKLTRDTRRNLFDAISRSNVHIRYEVKSNLRKITKGAKLSTKQVNIICIELLVLAHECFSGACDTEGVAVTLRSAQALAGRLLAARSWRLMVRLLTGLARYTECAYIFQALRDNHQFEYLLGQFDYMLGQQADRIAAFKHGLLDFLKTHCPGDTDAYIMVALHFNMYAEAADVKRRQALNLIDDLERIADEVRPKKTQPTWVMIHDNVSTRTLLDTALNHCTDAAELYLQGGCTGFAGEMATLAQQIALQMSLLNASPTRLILNRTPEQMYNLVSDYLSFMEGLVLLCGRGGGAWRELAYRRALSNDQAYLRDMAAYRPDVAHDFINRYKTEKKKTPVSQAAMTELRNLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRM3</accession>
    <name>A0A194QRM3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ragulator complex protein LAMTOR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRM3"/>
    <dbReference type="FunCoup" id="A0A194QRM3">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRM3"/>
    <dbReference type="KEGG" id="pmac:106718179"/>
    <dbReference type="InParanoid" id="A0A194QRM3"/>
    <dbReference type="OMA" id="WAAYEKN"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000004">
        <property type="entry name" value="ragulator complex protein LAMTOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13546" checksum="005C9512FBE83451" modified="2016-10-05" version="1">MLKPKALTQVLSQANTGGVENTLLLNHQGALLAYSGYNDKDARVTAAIASNVWSAYEKQGRNVFKEDKLHLILVDCQNGKIAITQVANLLLCLYAKDTVGFGILKEKINAIAQYLEGPLKQVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRQ6</accession>
    <name>A0A194QRQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRQ6"/>
    <dbReference type="FunCoup" id="A0A194QRQ6">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRQ6"/>
    <dbReference type="KEGG" id="pmac:106718100"/>
    <dbReference type="InParanoid" id="A0A194QRQ6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="516" mass="57101" checksum="56D026840731A44A" modified="2016-10-05" version="1">MLTGWRLALSKLFIIPQRYVLAILALLAVANAYTMRVCLNLAITQMVKRTVAVEGDAHYDPDACPDMNVVTNSSASYLQSYLRMDDVVVFEWSEATQGLLLSSFYYGYILTHIPGGMLAERYGGKWVLGLGLLSTSICTFITPITVKMGGATALFILRVIEGLGEGPTMPGLMVMLLSRWSPKEERGRMGAIVFGGAQIGNIAGSYFSGLIMHNGIWDNVFYMFGGLGLIWFILWSIFCYSTPNTHPYISDKEKKFLNENVTSLIHSQKADLDPVPWKALVRSVPLWSLIIAAIGHDWGYFTMVTDLPKYMTDVLKFNIKSAGLLSALPYVAMWIASFFFGLLCDFCIKKGYHSLKNARKIYTTIAATGPGICIILASYSGCDTTLAVFWFIFAMTLMGAYYSGMKINALDITPNYAGTTTALVNGIAAVSGIISPYLIGLLTPNSTLKQWRVAFWVCLVVLVVTNIVYLIFAEGDQLWWDDVKKHGYPAGWKHGPLPTKSKDAEESKESETTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRZ5</accession>
    <name>A0A194QRZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 6C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRZ5"/>
    <dbReference type="FunCoup" id="A0A194QRZ5">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRZ5"/>
    <dbReference type="InParanoid" id="A0A194QRZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10924" checksum="F1BCC13A4272DE27" modified="2016-10-05" version="1">MVHGWNNFKVELKKSNFMADKAVSTIAKPQMRGLLNNVIKRNLITAITLAAVAGFSFKQLVGNERKRRYAEFYRTYDAEKEFEEMRQKGLFQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS26</accession>
    <name>A0A194QS26_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS26"/>
    <dbReference type="FunCoup" id="A0A194QS26">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS26"/>
    <dbReference type="KEGG" id="pmac:106718227"/>
    <dbReference type="InParanoid" id="A0A194QS26"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="297" mass="32237" checksum="589C1E5569C00E46" modified="2016-10-05" version="1">MASVSFVTRVILSKNVINTGRFATLSNTGFIKFYSTAPQYENIKVDVVGTKKNVGLIQLNRPKALNALCKPLFIELGKAVNDFDADQSIAAIIITGNEKAFAAGADIKEMQNNTYSSNTKDGFLKQWEDISNCGKPVIAAVNGFALGGGCELAMLCDIIYAGEKAKFGQPEINIGTIPGAGGTQRLPRYVGKSKAMEIVLTGNFIDAHEAEKMGLVSKVFPVDKLLEETIKLAERIGTHSPLIVKMAKQAVNQAYETTLKSGLVYEKSIFYGTFATADRKEGMTAFIDKRSPNFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSU5</accession>
    <name>A0A194QSU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Huntingtin-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QSU5">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSU5"/>
    <dbReference type="InParanoid" id="A0A194QSU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17006">
        <property type="entry name" value="ANTH_N_HIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="87"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="1223"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="492"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="697"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="831"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1473" mass="165608" checksum="214DF3CC178F6B15" modified="2016-10-05" version="1">MANPTDKRFHQLTFQTNYRTQRRLKVNGHCSTPHPPDTTRSASRSPRHPPSSFERDEDINLIAECYVILACTGGRCFIRKGTTHHPLAIKPTAALTLAIQKAINAIETPVKEKHVRSTIIGTFQEQSAVTYWMVAIRQPLQDNRIVAWKFCHVTHKLLREGHPACLDDSQRHTGMIENLGKLWVHLREGYGRLVHLYCALLVSKLKFHQRNPRFPGNMQLTADELDAIAENDVNNYFQLCVELFDYMDDIFLEVRLFESLGNARANSMTASGQCRLAALIPCAQDSSHIYDCNVRLLFRLHAALPADTLIPSAIQEVKFFLQAREQPAVLQESSNAASLAIKSTEFPVTVICFNMLVKVNFSLLLQSELEEEKQRAEVLSAETPEIKQKLLQTEDKAKVIDEKFQKLKGAYTQLREEHITLIRQKAEVDKLSSNLRAAAAQHESSKMLLQQQLNDRMKDVELLQQSTSSSEEIEAYKNEISNLRDVELLQQSASSSEEIEAYKNEISNLRSELENSRQKEVELESLKASMETLEIEHKTAMTEQKEKVILVTNELKEVNENLEKVQKEKEEKEAELNRAKEELNAVKVESGADVKRILEEKEAALQEVAELKKQYQQEKENFNNEYEHSAEILSLQQKVDELVEGKKSAEISADLLESNNFNNEYENVKTDYDEMYRKQSAEVLSLQQKVDELVEGKKSAEIRADLLESNVNDLKNKLQEMTEIKVVIEKALEDKEKNISSVENKIKEIEHENIIEIEKLKKLLEKKDEFCQTKTAENETLSNKLSELETMLSSKDENITELIKKLNKELGVTDDVFNNFKELLTDKDQQILALNTEVTKLTDQLSRLEEELKETNAELEIGNNELIVLKDDFENMKVQHEFELSIKNKELQRLEKETSKVSAEKGDIEIEKNKIINELSVEKEVLENNVQEIKETMLKLNNDIDIIRNEKAEMENNLNGKINELNCIIDDTTAKLKEYEHDVINYRQVLHNKEITLDLVMKERDDLRTKLDEMEQIKINEKDEMDLVLSEKIKDNQMICARLEHTETERLNAECELQDLLQHNTVLEADVASLKAQLEEAQSDIKQQRSRVLSCAGEAALAVTCGALDAYEHGSARDTYRLAAELAANALNELATQKEISGNEETLAKSAVYAAHNTAQLSAYIMEVCNVSTDMELSDKLSNECRSMLSATKTCLQSVAAGRLEARQCAEALGGVRRAAESAARADAAPAPGSVDDELATMDTAIEHAAAQIEEMLAASRAGDSGVKLEVNEKILDACTTLMGAVKVLVQDARRLQQELGDISTRQKMYRRNPQWSEGLISAAKAVVFAAKLLVSSADETVNGKGRVEGVSAAAHSVAGSTAQLVAASRARAPPAAPSLARLTAASRQVATAAGAVLAAARHAADLARDTEALDTSALTLTATRILEMESKVRALELETALDKERARLAELRKRHYHLAQLEENGNMVNGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSV8</accession>
    <name>A0A194QSV8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QSV8">
        <property type="interactions" value="2510"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSV8"/>
    <dbReference type="InParanoid" id="A0A194QSV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2081"/>
            <end position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2315" mass="270208" checksum="E4953B4199BEC9F6" modified="2016-10-05" version="1">MSLPPYLLGPNPWATMMAQQQLAAAQQAALQAHAAAAAVMPPVPPSQPPKPHHIPEEKIKEKAQKWLQLQSKRFAEKRKFGFVDAQKEDMPPEHIRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVMKLLENMPMPWEQIRDVKVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEPIQIELDPEEDAAVASWFYDHKPLMGTKHVNGSTYRKWNLSLPQMATLYRLANQLLTDLVDDNYFYLFDSKSFFTAKALNMAIPGGPKFEPLVKDNSAGDEDWNEFNDINKIIIRQPIRTEYRIAFPYLYNNLPHFVQLSWYHTPNVVYIKTEDPDLPAFYFDPLINPISHRHSVKSLDPVPEEDEFVLPEEVSPFLQETALYTDNTANGIALLWAPRPFNMRSGRSRRAIDVPLVKTWYKEHCPPGQPVKVRVSYQKLLKYYVLNALKHRPPKPQKKRYLFRSFKSTKFFQTTTLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIVDSHVQYRLNNVDSFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVSKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKMKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRTFREVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLLPPWVKPADTEPSPLLVYKWCQGINNLQEVWEVGEGECNVLLESRFEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVLDLLVLGLQRASEMAGPPQLPNDFLSYQDRQTEVTHPIRLYCRYVDRIHIFFRFTAEEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLYCRSQHEELSHRDGVWNLQNEVTKERTAQCYLRVDDESLARFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHDEDQLIPNLYRYIQPWEAEFVDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKVHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFSAYKWNVSRPSLLADSKDTMDNTTTQKYWLDIQLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGLLIAIDLAYNLHSAYGNWFPGCKPLIQQAMAKIMKANPALYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNTERTKVLLKPDKTTLTEPHHIWPTLTDDDWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQSKEQSQLTATTTRTVNKHGDEIITSTTSNYESQTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKESGYTYILPKNLLKKFVTISDLRAQIACYLYGTSPPDNPMVREVQCAVVPPQWGTHQQVHLPRQLPRHPALAHLQPLGWMHTQPNELPQLSPQDITTHAKIMAENPTWDGEKTIIITCSFTPGSCSLTAYKLTPSGYEWGAKNTDRGNNPKGYLPSHYERVQMLLSDRFLGYFMVPSQGSWNYNFMGVRHDPNMKYGVQLGNPREFYHEVHRPAHFMNFAAMEDATAPTLAADREDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTF7</accession>
    <name>A0A194QTF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTF7"/>
    <dbReference type="FunCoup" id="A0A194QTF7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QTF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="458" mass="49326" checksum="B785D162965353C2" modified="2016-10-05" version="1">MPISSPVVFGSNEKWRINRNILVLGFAFMVQFTAFHGAANLQSSVNSDAGAGTFTLAAIYFSLILSNIFLPAIVIKWLGCKWTVALSFIAYMPFIAAQFYPKLYTLVPAGLMVGFGGGPLWCAKCTYLAVVAEPYAKLSGVSADVLVVRFFGLFFMFYQMAQIWGNLVSSAILSSSLGETVTYFNETLVTSTSDLVSNVSLPTVDFGATCGVNFCSGSTGHENTNLEPPSPLKIQVIAAVYLACMVSAVILVFVGVDSLKSVAGGDSATTSPPVPAAPSASYRAFVGCAYGISNIGFVMICFGVFNALAAPLAGAIVKITGRYPVMLTALVLNLCLISALLLWRPSPDQWLVFFVLAAIWGAADAVWLVQVNALSGILFPGDEEAAFSNFRLWESTGSVLSYASAPYLCVRTRLFILLGLLILGFSGYTVIEVMEYKVKKTHHRERNFELVAEKNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU50</accession>
    <name>A0A194QU50_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proto-oncogene tyrosine-protein kinase ROS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU50"/>
    <dbReference type="STRING" id="76193.A0A194QU50"/>
    <dbReference type="InParanoid" id="A0A194QU50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="161" mass="17204" checksum="780B9D11988714A7" modified="2016-10-05" version="1">MAPESLLSGVFSAASDVWALGVLMLELVTLGEPPYGARSTADIVAGLRAGDHPPLPANASPDTRHLLLWCWQRCPGKRPSAAQVRDALEQHSAALAPALRHEHPALTEHPALTEHPALTPLTENPALTPHTEHPALTEHPALTPHTEHPALTPHTEHPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWF7</accession>
    <name>A0A194QWF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative WD repeat-containing protein alr3466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QWF7">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWF7"/>
    <dbReference type="InParanoid" id="A0A194QWF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF28">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="5">
        <location>
            <begin position="544"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="946"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1425"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1648"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1659"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1670"/>
            <end position="1686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1686" mass="187607" checksum="3FB0075879CE7905" modified="2016-10-05" version="1">MSAPEPAVLRALQGYTDHSDKWPGPRLVKIYLASIYNEFREERRHLLEMVGPELQATYDDRHIEIEFVDMHYGTDGKDETNPALLRYHLDEIRCCNHTSKAGYFLCFIGGDASQYEPVLPFKIPVNTFEKLVKSDSAQAALVRACYRLNGNNAYQLEGDDKWFSDLLEREDQRSRLSAIQKAFKALALEALGEKDGLADLLRSSTEIQCELALELLKNGKHPKGVIAVLKDIPDLEHDDSKITVLAHSRLKKLQRKLEETLPEGHVIRLEVPSADSSRTDGASDNDEKLSPFRDQIQTVVSSLIDDSLSTEPDQGRGRKKTVQEVFLEHITHLRICIEHNSLYKVTVKQIADVAKTILNTVKENYENRCRHPPVLIYGPDASGKSTLLTHLYFQCEKLFSRPVLRIIRFSAATPRSAYNLELLRVMCQQISIILNIPEGYLPKDASFDPLYINNWFQSLLRRCEDMENEILLIFIDNVHRVNPLECDIVTGLSWLPMSLPRNVFLICTSAVSLQQLQLTPAQKEKFKIQNCYYLLDAIEETSDNHSYGDYIDGAFDNLETVFGAKAFSKLAGYVTCSEFGLTELELLELLMPTSNSEAIITLQDANFNFSTLCVTKYMMKSLIVENVVSGRCTWRWRAAAAGARARRRYVRVQSALRDTHSDLAALHFANFLHESDDTDTSEAQELGCVDDDDALLDSTPFHSASRTAAAFTQRHVEESWLHLLLAGDFSKLKDLTVCNFDFLLAAVQTVTISYLRCILEHVRCYILDRDVELVYGAVRKSSDILTRDPMQLGAQVQTVTISYLRCILEHVRCYILDRDVELVYGAVRKSSDILTRDPMQLGAQIIAWLRPAIARRGVLATLVTAAMAWCDGYDKPLLVPLNGWLQPPIASTVRVMSVGGTAVGTAGGAGARLLQLAPSGQHLVLAPAAGDPQLWHVMSNSRVHTFKGHSGRILCMCVTRESQYLLTGSEDTTVVVWDLHTLAVKTKILEHIAPVLCVAAIVNRSLVISGGEDSAVIVTSLVDGALVTKLDHHRGPVTSVKVILDGEILVTGSHDGTVCTWNVDNFTILSTITVGTPIHIMDVTDDNVFLITLQGDHELHLRTFITGTYLHALKRHKAKVKCFCVAHDSSRAAVGCADQRIYIYSLHSGQLLRTLAAAHDLAALAVADKDHFLFAAGGHRVTIYSFHTEDNLTNFRPTKQMKRRQTKSTTNITLLQAEQSELIPISCLEVSRDGQLAASGCARGLVRVWHLSTHRLQTTLNGHIGHITCVTFSPNNLLVLSGSEDRTVVVWQLADNSPSLTYKGHSAALQTLLMMSDGRRAMSGDRARNIHVWLVDSGIILHSANGPSATIDVTLNMKFAVLSDGDNSIRIWALTGGEEERRSVSHAERITCFALTADSQHVVTGSMDMSLKVWQLDGGKLSQVLVGHTDIVTCVAVSITNKTQVVSGSWDFNLIVWDINTGSDVHLLSGHLGKVTCAEDKTLIIWETKRGLALTSLALHVPLLGFQITSDCARIVVHLLDRGCLPIICLHNTPATYVKIPTYAAPTKDIDELRPLAPKRPMRRLLKKEVSLDTYTWQKKYGHLTSAAMMAQVDERLKRRFSVSASMEEISKIQEAKNKDLGSQVSLGPEEAAIAQSQHFDQLEALWNKISPPRRRSNKSLSKQSSLIESRFDSSDEEHTPVEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWH5</accession>
    <name>A0A194QWH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWH5"/>
    <dbReference type="FunCoup" id="A0A194QWH5">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWH5"/>
    <dbReference type="InParanoid" id="A0A194QWH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264693" evidence="1">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PLOD1-3-like GT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="48825" checksum="0CF22C2BC0593E00" modified="2016-10-05" version="1">MKKLLLLSLLFVGYATALDDVTVVTVATEDNDGFKRFMRSAKVYDIDVHVLGQGEKWEGGDMNFPGGGQKVNLLKQKVEELMKTKENDHIVLFTDSYDVMFLGTLGDILVKFKAMPETRVLFSAEPFCWPDPKLAVMYPNADVTNPYLNSGGFIGYLSELNTILNARKIKDTEDDQLYYTKVYLSELRDSLKISLDHKSEIFQNLNGALSDVQLRVNTTEEWPYLENVATKQRPLVVHGNGPAKLMLNTMGNYLAKAWSLKNGCVLCKERKIELNDDNLPHVMLAIFVEQATPFIEEFFDSVLLLDYPKNKIHLILRNNVPFHEAYVDEFYNKHSKEYATAKRIKPIDYMSEAEARNLAKDRCASSMCDYLFSVDSVARLRPQTLRHLLSSGYDVIAPLLANFELQLPSVLLSLYYHTDVYLKNVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWL7</accession>
    <name>A0A194QWL7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWL7"/>
    <dbReference type="FunCoup" id="A0A194QWL7">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWL7"/>
    <dbReference type="KEGG" id="pmac:106718456"/>
    <dbReference type="InParanoid" id="A0A194QWL7"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="175"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="37169" checksum="70314D4CF8B19549" modified="2016-10-05" version="1">MKARYLTFFSYIGTKFRSSEKIWLKGGKNYPDPESIQGLMEIGLLKLRPLNYPNLTLSSRTDGGVHALNSSAHFDLERYGTNVYDPEYITYQLNKFFLKNETSISVKKCLRVSDQFSARFNAVSRTYLYRLAVLKPDIELPESSIISSYMPIEEWKRCHFIRLPGFDIEKFKAGAKYLVGYHDFTTFKKFDKLTSHKQNRRSIQSFEVKPGQPLVTSYSSTQDNVFDYWDIEIKGRSFVHNQIRRMVATLISVAIGKIPPEEIKVMLQVPSKHSWHTFIQNCPPDGLYLCNVEYNPEDLVYEKENIVDESNTEESDTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0A7</accession>
    <name>A0A194R0A7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat-containing protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R0A7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0A7"/>
    <dbReference type="InParanoid" id="A0A194R0A7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1246"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1400"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1819" mass="209411" checksum="A55A7EF1FDF13E2C" modified="2016-10-05" version="1">MDVKTKQTWFRRSTTGGSVGNITSYRVDPNYRIAIAEGREGDRDPLILLYTWPQMEIDAVLRDGTSNAYSIMDFSPDGELLASVGKEPDYNLTIWNWKKHKILLRTSAFSFDVNAAMFSKYCPGQLTTAGAAHIKFWKMAETFTGLKLKGDLGRFGKTEICDVLGVYPMPDEKIQFMLSPAGDEVTTISRDGCVRAWYWDTVEQADPPEDDPFVELNPVAETCVPGCQIMCLKHQKDMYWYAQFSSYSFSKDGNGGIWTVDIEIDKIECNHNKISTYHAGEVIAMVALRLHPILLTVGCDGALQAYSTETQMLLARYQFPNAVTCMLYPPHEVDPSARIVLIGFADGVMRTLLIHPDILQAATALIDVRIHSALTIHSEDSLNPDALDLISLLKPHSKSLTQITINYQNTLLVTSGQDSTIFMYQLKSGRPFTLNRLGFITTPNNVTYMTWKPDEERVLLLCGPVGSLMEVVLPNAEVQKYSEITTFKLEFISSKQTQIKKHFLRYRPFPQEEDLASIDEEALKAKEEAEKEKDDEEEEWIGEIQLIEDETIAGTTLTWAAYCEEGVWTVQQDTGALLLVRPGLSKIFKYGPIPEAWTEDITTLKFICDGAYLMIGTNTGYIRVVRMPLEDEDNEDYHYMTWRLAQQKLLRKLKGRRLAKEETQPTPRIDFNDYYYLPMHDFYTGAITCIEISADGSRLFSCGKDGNIFSYTISFPEPLIPKFELKPIDLPKVPKMKEPSTIDGELMSHEQLKQKEEYDKKMAIANAHKKQVRDQLAELTVEYNKLIKANKALPYSQQIDVTLDPPPLIEQEKELDEAKALTKRKLAHQLEASDLGYQKMYTRNIIQLDVFPFTLKAIRDPNIMLRPLRQKNLSKAFYEQFDEVHQKMAEAALRGRRAESIARRVISKKASWGPPRVASFLLGLPPRAPHPLKKAIRNYYKRLNRHHLQFIEWHEHSARKPDPNAMPPGAAEALKEAEATIGNRLLKTQPDYVAPPGHNTQLRICTKRKEIHDNKHEFNEKVLELRQHKLRLVDRMKSIGDRLGEIRSEIPHNMVKQPPPVPAIDEALEFPEKNLEIKPEVTVKHHMTLTKKIQQERRKSISLSQPRVRPSRVARFVPITVTRPLAASWELLKTKQDQETSAVEVEIRERRIKRHLYEQDMLLADAAVSIQQFDSRLRELQRERIRVQIRGVQEQIEDCEHRIDEHYTEKEMLDASCQEIQSQFKRLVHDNKFADFLRRIFKKKYRPPRDRDDDESSESESESSSSEEEDDASLDSRDIGPIRLDPNVCPEGCDKEIYDKTYELRNTRHRHEQEMIEKDRLVELLRKDIEAHNKVKRTLTIQLDKRKNDLREFMMEKQNCMNEVDQVVVLRYDQIRASAFRGCTGPQGLSNTVVFPERLLQKLRQRVLELRDEIKQQRQRHKINRTHLFRMNIDLKAMEEQASELRAKMRDVLTRKLGKPRRVDRTLDDLLRQMARRHKFTSAVGTMPQMQMQIRQWHERLGELEKKYLKELDHYSDRLRLASALQADILPQKPCKDPNVMVGNYEPEQYQRDVVRLRIIRSQQLQQIAALKEEIKGLRTKPFPQEIGPVVQEVNVMSLLYDCLDAMRVTRDDADQLLKDLTDQLPDVLAGTKSRFEVIDSLVRKWLLKHGGDPSLYKKQTRAFDALAALADRLIKEHIAAMEGAEPKELEAMKSLEDALREVSDKDQTLHRRLGPALAALMHTTDMEELATPETMTLLVNSLIGGDHRLTAESVDRIQPDDVIEDIRECGVRAPINELRKIVKLAVDCLRSQLIGPEEAKFLDAEVAKALSVESLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0L9</accession>
    <name>A0A194R0L9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome-associated protein ECM29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0L9"/>
    <dbReference type="STRING" id="76193.A0A194R0L9"/>
    <dbReference type="InParanoid" id="A0A194R0L9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="53913" checksum="A54753032F7EC782" modified="2016-10-05" version="1">MSEMEVTETGSDCSNDLLLLDRVFLRLGNVDTDEQLESCLNRFLPPVILKLSSPHEQVRTKVMELLVHVNKRVKCRADVQLPVQTLLQLYKDPAANSFIINFSKIYITMGFPRLPREQQLILTPSLLEAIENKPQPHQDGILMLVMPLLGDIKETDLNLKEKPKVSSLILKFALDILLLPYRALPNAGESEFQVPPGMSMKTYKRIVGNNQLNPNQLEEMKLSIVNFISKDIFNMNDILLTLIVAAADSRFSVANHANSPLIRVNSSVDWSQPAVVGPLYSLYLGTWGGMKVPPDDRKVPACTRLRLKLIQYLNKATGPAIMFPHCVQVVFSSLFDPNTNSRLRNLSLMFLLNVINNGDSEQLKKVGTVFLHGLLKLIRSDEYADHHSKAYMCLGRLAMKCPESINRQFTLLEELVKKIPEAVPEMKTALRDALLDMSVAYTMHTPDEAMDTSAAGTSNDMDVDEASESKKPRPNPYDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R168</accession>
    <name>A0A194R168_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C4orf29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R168"/>
    <dbReference type="FunCoup" id="A0A194R168">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R168"/>
    <dbReference type="InParanoid" id="A0A194R168"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="563" mass="64226" checksum="37F7EB73C8CBC3E7" modified="2016-10-05" version="1">MSTSRLDAVYRSILITKFFTKGWGKPENLRRLFEFRKIVSNRDECFKLVEKDYPVTITKEQNLSDCKLLEGYFLTPLERYLPGIVPEIAQKAHFQALLPLHWQEKGCKPVCLHLAGTGDHYFWRRRNLMVKPLLKEAGIGGIILENPFYGLRKPTDQIRSSLHNVSDIFVMGGCLILESLVLFHWCERNGLGPLGVTGLSMGGHMASLAATNWPKPLVLVPCLSWSTASAVFLQGVMSHSINWDLLEDQYLSDGAYREKLSKMVTIVDEAFLAGKKFARTYSEKVKIGIQTNTQIEKQEHLIKSLKCDSYKDLIICQEDKAKQQGDTKVDLNTKVPIKIVKSEEGTTEFDNLNKDLNLLLNENKITSDSNEIQKSTEQVSDRTKLKQTENLLSTETSNKQSSLKSVTANTKKSKETEQLNNIIEQIDKKSEKKSWNVSEMTSDFWTNLPFIKSGKKIDIGKIHWRDREALQFMRGIMDECTHLSNFSIPYDTSLIIAVCAKHDAYVPREDVGRLEEIWPGAEVRYVDAGHVSAYILHQSVFRACIIEAFERSKKKWKDGKHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R171</accession>
    <name>A0A194R171_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R171"/>
    <dbReference type="FunCoup" id="A0A194R171">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R171"/>
    <dbReference type="KEGG" id="pmac:106714884"/>
    <dbReference type="InParanoid" id="A0A194R171"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="219" mass="24891" checksum="A695233E83FD7391" modified="2016-10-05" version="1">MGGADIKWQKDAGDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEEERVVSADRGRQLAEQLGVEFYETSAKENINVKTVFERLVDIICDKMSESLDSEPAMLAGGARGQRLTEQPQNNANPNCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1M0</accession>
    <name>A0A194R1M0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osteopetrosis-associated transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1M0"/>
    <dbReference type="FunCoup" id="A0A194R1M0">
        <property type="interactions" value="763"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1M0"/>
    <dbReference type="InParanoid" id="A0A194R1M0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019172">
        <property type="entry name" value="Osteopetrosis-assoc_TM_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644">
        <property type="entry name" value="OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644:SF2">
        <property type="entry name" value="OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09777">
        <property type="entry name" value="OSTMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="28122" checksum="BA11A91163D52C2C" modified="2016-10-05" version="1">MYSYPKECYKILESFSQSASNLTMCSILNARPVRLCEKCVDHYVCFRNKYQELLKTVVNGTSCRSVFMSHDRLNVVLQYHDSISAVWEQGNCNNCFNWTDNKPAIKNDINHFIKLFNDTMNCFSNNYDPENNNTVCEKCMQFYLQLDSFYATLSADSMGLDSVCMDIVDSMNATRSIWSKTFNCCKLRRSPEIVFLSSAGVIALLPLIFYISVRYCGPIRDLPQVLKQSRIKQTILRSINSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1Z9</accession>
    <name>A0A194R1Z9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RuvB-like helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_14914</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1Z9"/>
    <dbReference type="FunCoup" id="A0A194R1Z9">
        <property type="interactions" value="1574"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1Z9"/>
    <dbReference type="KEGG" id="pmac:106714847"/>
    <dbReference type="InParanoid" id="A0A194R1Z9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 14 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="49916" checksum="C31A5C80BE6AC084" modified="2016-10-05" version="1">MKIEEVKSTAKTQRISAHSHIKGLGLDENGVPIQMAAGLVGQESAREAAGIVVDMIRSKKMAGRALLLAGPPGTGKTAIALAIAQELGNKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIRETKEVFEGEVTELTPVETENPAGGYGKTVSHVIIGLKTAKGTKQLKLDPTIYESLQKEKVEVGDVIYIEANSGAVKRQGRSDTFATEFDLEAEEYVPLPKGDVHKKKEVVQDVTLHDLDCANARPQGGHDIMSVMGQLMKPKKTEITDKLRKEINKIVNKYIDQGIAELVPGVLFIDEVHMLDIETFTYLHRALESAIAPIVIFATNRGRCQIRGTEDIISPHGIPLDLLDRLLIIRTLPYNKAELLQILKLRATTEGIAIEEDALAALSEIGANSTLRYAVQLLTPASLTARADGAQRISPPHIQAVHTLFLDAKSSARILTQHSDKYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3E1</accession>
    <name>A0A194R3E1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine sulfinic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3E1"/>
    <dbReference type="FunCoup" id="A0A194R3E1">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3E1"/>
    <dbReference type="KEGG" id="pmac:106713752"/>
    <dbReference type="InParanoid" id="A0A194R3E1"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF12">
        <property type="entry name" value="BLACK, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="508" mass="57368" checksum="DA66FEC4BFD95014" modified="2016-10-05" version="1">MPADSNLIVAGEAIKESLFQSLPDRSKHEEFIRRAVDLLVERVVFGRSQRSAKVVEWAAPDEIKSVIDLKPREGPISHDELLAIMADVARYSVNTGHPYFVNQLFSTVDPYGLIGQWLTDALNPSVYTYEVAPVFTLMEEEVLREMRAIVGWKDGDGDGIFCPGGSISNGYAISCARHHFYPDVKSKGVYAVPKLVLFTSELAHYSTKKMACFMGIGSDNCITIKTDELGKMDVEDLEIKITEAINAGSSPFMVTATAGTTVFGAFDPLIPISGLCKKYNLWLHVDAAWGGGALMSKKHRHLLKGIELADSVTWNPHKLLAAPQQCSTFLVKHKNVLKEGHSSNAKYLFQKDKFYDTSYDTGDKHIQCGRRADVLKFWFMWKAKGSDGFEKHIDKLFDNAKYFLDHIKQRAGFKLVLESPECTNIMFWYVPNCLRGCENDPNYRERLHKVAPKIKERMIKEGSMMVTYQPQGNLVNFFRIVFQNSALDHKDMVYFANEFERLGSEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3Y0</accession>
    <name>A0A194R3Y0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3Y0"/>
    <dbReference type="FunCoup" id="A0A194R3Y0">
        <property type="interactions" value="1406"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3Y0"/>
    <dbReference type="KEGG" id="pmac:106715691"/>
    <dbReference type="InParanoid" id="A0A194R3Y0"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="10241" checksum="A5A912C94122BC51" modified="2016-10-05" version="1">MSDLSDYSSTKAGDSELQDFLMVEKQKAQFHAQIHEFNDFCWDKCVDKPGSKLDSRTETCISNCVERFIDVSLLVTNRFAQMLEKGGGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R630</accession>
    <name>A0A194R630_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R630"/>
    <dbReference type="STRING" id="76193.A0A194R630"/>
    <dbReference type="InParanoid" id="A0A194R630"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="260" mass="28784" checksum="12933D0EEDD8FF63" modified="2016-10-05" version="1">MEEEDDERKVRRQKLAAFTSLNARIVHSSLEEGFLRQQASSESADANTSSISTAQFSDRSFVSKTSTFSRSGTSSSSQEECEVAQTTITSGQYLAAARVETARSMESLRPSKDTSPARPASSCTTVRVHRSSFLTASERDVRESRGLPARRALSGEDMGNSAEKRRGLFASTERRALQQLSLPPPERRLTILSPHSPLATTELQWPTPPGIRGRRKKGMVLPKLILPRSDSDGSEVFFESITVKENHYPKIIVLLQLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R772</accession>
    <name>A0A194R772_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMRFamide-related peptides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R772"/>
    <dbReference type="STRING" id="76193.A0A194R772"/>
    <dbReference type="KEGG" id="pmac:106712574"/>
    <dbReference type="InParanoid" id="A0A194R772"/>
    <dbReference type="OMA" id="GYPQRKS"/>
    <dbReference type="OrthoDB" id="5813613at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF22">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264965" evidence="7">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="21341" checksum="4DFE359BC6F7262B" modified="2016-10-05" version="1">MACSKSITLLLVCLLSSVLCNPVRRSPDLEARRRSADRNMIRFGRSYPHEATAAEIRESLQRPTRRGNSFLRFGRSQPLTFTTDDLISLLRSYEEDYDTPTKRVSNFVRFGRDPKFIRLGRSVDDEKTYEQNTDLYVNGNPQRKNRARDSFVRLGRDSEDVIETEEVLDERRKRSVECDDCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7H6</accession>
    <name>A0A194R7H6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II-associated factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7H6"/>
    <dbReference type="FunCoup" id="A0A194R7H6">
        <property type="interactions" value="1779"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7H6"/>
    <dbReference type="InParanoid" id="A0A194R7H6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="519" mass="58839" checksum="43B7F9AB3FC0A4A0" modified="2016-10-05" version="1">MPPTVQTNEPEREKRPQRTGERRSELVTRVKYCNTLPDIPFDLKFITYPFPSTRFIQYNPTSLEKNYRYEVLTEHDLGVHIDLIDRDIYQGDGNATLDVADEKLLEDDVLTPQDSKRSRHHAKNVSWLRRSEYISTEQTRFQPQSMEKVEAKVGYNVKKIFSEETLYMDRDSQIKAIEKTFEDNKKPIEKHYSKPGVTPVEVMSVFPDFDMWKYPCAQVIFDTDPAPSDKNIAGQIEAMSQAMIRGVMDESGEQFVAYCLPTEETIQKRRRDVTEGIPYMDGDTYEYKMAREYNWNVKSKASKGYEENYFLVVRNHCVYYNELETRVRLSKRRARAGVAAQALTRLEEDEEEEEDEEEDEEEEKQEQNEEKERSRSRSKSGSKSPQGSEHSKESNRSRSGSREKSRSRSKSKSKSRSRSRSASGSRKSRSRSGSAQSGSASSKASSRATSRASRRSSRASSRASSKASGSKASSRASSRKNSGSGSGSDRSRSRSASGSRQGSRSGSASSASSKRSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7Q1</accession>
    <name>A0A194R7Q1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7Q1"/>
    <dbReference type="InParanoid" id="A0A194R7Q1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13692" checksum="B5E9FD5754F76892" modified="2016-10-05" version="1">MPINAETVNLAATYMILLNVVVSITASPPDSRRLPSKRRFYYCTLIFINVDNIWCERGVASRRRSSAGDSFVGRVSFLERLVKCRAGAVCNMPNHETTSLIATYLILVLLLASLWLLYSGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7R7</accession>
    <name>A0A194R7R7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylphorin subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A194R7R7">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7R7"/>
    <dbReference type="KEGG" id="pmac:106712172"/>
    <dbReference type="InParanoid" id="A0A194R7R7"/>
    <dbReference type="OrthoDB" id="6371642at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264980" evidence="3">
        <location>
            <begin position="17"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="162"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="447"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="702" mass="83610" checksum="4E89A623AB4B056C" modified="2016-10-05" version="1">MKTLLVLAGLVALAMSGAVPTETVHFKTKTVDAEFVTKQKKIFELFFAPSQISKDAEYYKIATEWSIEANIENYTNKKAVEDFLVLYKHGFLPRNHVFSIFYEKQKDEAIALFHLFYYAKDFDTFYKTAAYARVFLNEGQFLYAYYIAIIHRPDTKGIVLPAPYELYPEFFVNSDVLYRMYRTKMQGGISNPDFASEYGITFENNYYVYNTNYSNYWTYGDEEYKLSYFTEDIGLNSYYYYFHSHFPFWLEGDVFTVWKERRGEAYYYFYKQLIARYYLERLSNGLGEIPEFSWTKPIKTGYIPFLTYYYPFIQRPADYQIPYESNVQELQFLDTYEKTFLQYLERGRFKAYNQEVDFTNSKSVNFVGNYWQSNVDLYEKFGPRNYHRSYEGTARRLLGASPEPVDKYSYIPSVLDFYQTSLRDPVFYQLYSRILKYFIQYKEYLAPYTQDLLHYVGVKVTDVKVDKLVTFFEYFDFDVTNGVFFAPEQLKTYKFTPYKVRQPRINHKPFTVTVDVKSEIEGDAVIKVFIGPKYNGEGYPLTLEDNWMNFVELDWFVHKLTAGQNKIERSSTDFLFYKQDSVPTAQIWKLLEQNKVPTHMSTEADFMPSRLMLPKGTKGGFPYQLFVVVYPYHGKEHTSELDSFIVDNKPFGYPLDRPVNEPYFIQPNMYFKDVFIYHEDEIYPYQSNYPYYVGHKTTYTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R863</accession>
    <name>A0A194R863_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R863"/>
    <dbReference type="InParanoid" id="A0A194R863"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264983" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="8461" checksum="A17828C291495D61" modified="2016-10-05" version="1">MAIAMGGLQGAAAPSRILNNMSVLFVAALFLASVSAKPQVLLDTYGYYAAAPAYVASYSAPLAYSYPYAYAYSYPYAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9G1</accession>
    <name>A0A194R9G1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Receptor-type tyrosine-protein phosphatase beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KPJ14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9G1"/>
    <dbReference type="InParanoid" id="A0A194R9G1"/>
    <dbReference type="OrthoDB" id="5794147at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265020" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1631"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1726" mass="191005" checksum="6E62DA02A0EB3362" modified="2016-10-05" version="1">MESPVRICIGAAIVVNLLLICTLVNGGPLSHEASSTTIKDEKTTKYSRMNSTWTTKNQPKTPDVALNELHPKESTSEEHTEKNAKYKDRGRVKFQSHLKSTSESPLRRIKSSTEPTKYVSSTTETMKSAKIANDIGKPRDKKSSEVSSSTTSSTTSEEEEITESDDMQEMNDSQLAEADEDNIFDRYTSSKFQDSFNLPGYNDDDSYKDKMYSQTKHEFSNFDKVLKHFSKNMFDSSENDNVHGDPYNSHSYFDFEADLTTPRNDYFDQKYADISSSIMNNLASVKTKSPEMNSTTPQDIITENIGFEKLSNGSPNNKSMMIIKNTKEIRRLDNDQAGTANRELSDIHGTSIYYEMSVLSTETYNINHSDDYDCDNDTLPAETTMSTSLQEEDQSLTAVQPVMATASSMPVTITAIPAIVLPNVIPNSLNTIIPIQDSNIPISSQNYVSNTERTVKVSPRNRNYSKRLNLTGNKVSPNSVTPQTIPTMNSGWRPVTHKFYFTTPKIKPIWIAPRRNISKVYKTSYPTTIYAEHFNIKDKYSTTPRPMAPQKTILTTLPSDIDPVLQSDVSGVEKFVQSQIITDNTIPTLSKRGSMKFTTSVPLSANNTEHKDPTNIIGTSKEGASSSISLTNSSKEIETVDEAGTTASVSSASQTQFVNKISSTDKNTPSKISTVKTITPNLSVSLDEASTIDKTGEMDLTDPLSATTNSESDSTEEKDYLNQTGTIGNSSATSNESLDQTESVSQSNSKNISETPFGKTNKVREGSPPGSTESVGTASVEDTDNTSQTSSEWVTSVGGMSINDLEIPPTMTAWALASLRTPPTMSIKVLNGSQSTQKTVDENELQKVSEPLDQKETTTVSTTPTTTPVAALSNYVLKNITEIDQNKLPWKPIISIEVRDEKEPVTKSERLPAESNISVQSSLKPENTTKRTQTEEKIAMTTETIKINDARPSWIPAMINETTTEETDENEDEIQPVDVKKSTGFESITKLPSGVTTPTDENDTSTEQSEVRTTTDYDITTIRFSYVPTEQMTETEVPIINKTWHKIIPTRTNKPTTPITTYRPTFSTTTEETEETTTMIVDTTPQLESSSINDNATNQSHEGIGQTTTEEITTNNPTTTYPTTSNPTTANPTTTNPTTDSTTECDETTTMTTAASMMQRTDPEEMPQIATTTEPPIQTKNESISEENSDSNEVIQDTTKPPTTTTIITTTTITTTTEKGPETTVVPSTTEQTTPGYSETTIKPNENIPFHHEEDTTTESSEMTTKSINELEDLTSYTDDMTTEASSRVFTNEETSSGATIAIVVTTIGVTALILLVVLLLVVRRRGRRGVYAQRCTPVSLDAYSLDSVSVGHRKGNHRLCSKRSYGNPAYDDEVTSHPMQYAALANFALDVESISAEFAEIPSVSVPPEAVPPGCEDKNRYSNVLPLPETRVPLTRLGNDPTTEYMNANYVTGPGNIRNYYILCQAPLANTVADFWRMIWEQNSRLIVMLTEYMENGVEKCYEYLPPSEVSDNKRCFGDFQVVLKKREQRDKYAISTLQLIHMGTRTWREVTHLWYFWPAKGVPDDYDSVIDFISEMRSYMKISQTAKEYDEEGVEVIYGDDTKSSLETLSKLRSEGRASGRGPHVYSPARAEEMMRSNNGTLRSQGVRPCVCVCASGAGRSAAMVALETCARALSAGAVDVPRVVRRLRAQRPHALANRHHYIFIYKVLSEYGNKLMGSGVDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA61</accession>
    <name>A0A194RA61_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Esterase FE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA61"/>
    <dbReference type="KEGG" id="pmac:106711163"/>
    <dbReference type="InParanoid" id="A0A194RA61"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265039" evidence="5">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="585" mass="67408" checksum="A46C8ED7B0638E66" modified="2016-10-05" version="1">MKLFLLLCLITYFQQLKTNENNVNVKIQQGELEGKIDKTLFKNLSYYSFKGVPYALPPTGELRFKAPVRHDKWVGVYEAFTEKPTCLQFSSRQRNGESFGISGSEDCLYLSVFTPSLEGSAPVVVFDYNDNLKTGFNGTKTYSPDFFLEEDVIVVTINHRLGLFGYLTTDDDVIPGNNGLRDFIMGLNWIQDNIKQFGGDPNRVTLMGNRGGAVLIDTLLYSAKAKNLFSAAILQSGTSIEPFLFYDKPREAAFELGELCDINATDSYSLLEELQKIDAEILITKDVSVTDKTFDLAQLVIQPFSPIVEKNNPDAILTSLPENGLVVNDVPIIIGMNSREGLDLASPYIFEPRLLTEYNQDFFVHLPKRTGFQFNRNSSIFQEAVKEIQNFYFEEGYLHYNNILEYAVYVGDVLQNYALNLAAEKFSKDLKSSVYYYVFDFRGSLNENIEYMYRRIRFPIENWGATITDELCYLHLCTRIKNNYMKLRKLLSEQPEMKVLKNMVRLWTNFAKYRNPTPDASDELLKDFTWQPLSKEKYNYLHINKKLRMKENPMGERLKFWDDFIAKYSVMAEDGVVNDKNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA74</accession>
    <name>A0A194RA74_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chorion peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA74"/>
    <dbReference type="InParanoid" id="A0A194RA74"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF106">
        <property type="entry name" value="CURLY SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1474" mass="167969" checksum="0E2D446890673BA6" modified="2016-10-05" version="1">MSMVSGRFATSANTCGRLVVCHLIMALLLALWGTYAAALASLSIPADDDCALYLTGPGRSSAYDYSLNLLKGNFEYLKTFFTFMYLFITIKFENYNFNSINCNLLTFVSCYLVVAQPKGDWKPEDFASVGELVLDISIQLARTYGLTYEEIEKGLPLIDTSRTLIREVCPPVFSHVECRAGKYRRLDGLCNNLQHPTWGATMAPFQRLIGPLFSDGINAPRISHSGRDLPLSRVVSRTMHPDDGFHDHAGTVMVIAWGQFMDHDYTLTGTPLDPVHRNDPEECCKRPLHLKHPYCNEIIIPDDDYFYRLFGVKCIDFVRGFPSPRPGCRLGSRIPYNTLTGVIDGNTVYGVTDKFARKLRTGYGGLLRMNPVFKEYGLKDLLPLKLDIPDEGCTRPNKNMYCFEAGEIRVNEQLVLTVMHTLMAREHNRVAEGLAAVNPHWDDETLFQEARRINIAEIQHITYNEFLPILLGKDVMEKFGLVLEKQGYWNGYDPDVNPDVIASFAAAAYRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYVMGLMNQVAQAMDDSITQEVTNHLFKKVGARFGMDLVSFNMQRGREFGLPGYMEFRKFCGLSGADTFDELFGSMPNETVRKYETIFEHPIDVDLWSGGVSERPLPGSMLGPTFACIIATQFSYSRRGDRFWFELPNQPSSFTPEQLSEIRKSRLARVICDNTDIIDTVQLYPMVLPDHELNPRVPCRSGILPQMDFSKWADPIPFHGSAKQFLPSNENQNITLNKPPYNATEVKSIKNTTTDDVNDKVSNSTIKEQIIEVPQKDNHNVTEKSAGDTQTAFNEQSTIESEYILNDNNDTLLKYIYKKNEKENLPLKTKGHVQNSLKRRKRFINSSDSEIVPKAKILSVPVHYLDSNQGNIKEEKFLPVTQTRGIVQSSNLADFNIETIHNDEAKPGNGVNIKGNNHPNAAINAKFYPRLQNDETKEESQESVENNQNKHRLKNDVKTKDLDENRSGSEETSSSFESESVETPNISTSSEYNKDSKETEKYRDSVNPIPRKRKQSDENHESDKSYESSIENSSEANQGYIGKSIELHSDQGNKNKPLIVPKQEAEDYINLEINKSDVEKFPKVSREKYTKDDTADSLETPKISEEVSNESKSDESKEIYTDSSSVEESKDIKSEKQTLINDEEIKPVVELNNGSIESSEEVSEEDGNSRLKNNSKLVSLTPVKIFDIKNEEISALNDNLDKVNIKQQFERIPLDYIHANEVNKNNTSNTTASHIKPTEISSEEKDKEGTLDTLSPISPTYDDELNIKFHDVSIKLPEIKLPEDILSYAYDGPYYETKKGKDKEGQKPKFYYNYEDDDLDENTKEKNIYEEDDFNDYYKEDKEYDNVQQNSKIKNEDDDSEDLYEKFVRERFGKKSIKQRSQKIQDESIPSQLKLRKTLKNILKKTENVKKEAEKSGDPNANYMWTLEYGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAC8</accession>
    <name>A0A194RAC8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAC8"/>
    <dbReference type="InParanoid" id="A0A194RAC8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="14204" checksum="4FEDB7B613C5BA20" modified="2016-10-05" version="1">MATPGSKKSSKDWDKVSVNSAVQWCCYVLLLALCGYSLYRQHGLERRLHLLEQQHGGLRRLVAALQPPALRRRRDLTDCICPQDRDRAHKSAFIQFSTAIIEVAVDVGVSACEGKAVDLGRILKMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC53</accession>
    <name>A0A194RC53_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09209</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC53"/>
    <dbReference type="STRING" id="76193.A0A194RC53"/>
    <dbReference type="InParanoid" id="A0A194RC53"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000006">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF30">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="367"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ15182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="619" mass="68757" checksum="56A5AD0E9D7A374C" modified="2016-10-05" version="1">MPDDEEVEARDSEDTLSDMRDDDEDSVLSPQDESESNEESKILAMLEEELVNRDDDKELADATNFCLKFKSIEAESAFTLRTDVCPLAAMLPPLVLLPAVAAVASFAAPSAWSLHAVYLALELEIGLVNVLYYACYKYTQFKKKTVSPMWKLTCSIFNVTMFVTANVTTMVICGDFDTALSADGLREDAPARGGARRCMHPSYYYHMGAGAACCTLWPALVGGVMRFAYLVSMALMHTLPALYVPDLLAPRNRARDPYHTLLHHANTTHYADQFLSVMVHLHSARNIIMLFIIAIALVVYNRYSESLERARHSRGERMRAQAEQAIDLRRRNQALVHNVLPPHVASHFMGARHHHRDLYSQSYAEVGVLFASMPNFSEFYSEETVNNQGLECLRFLNEVISDFDLLLEDSKFSKDIIKIKTISSTYMAASGLNPTRQMQPSDGVLVRWAHLACLVEFALELQRVLTAINEQSFNHFVLRLGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGCIQVTEETCQILQCFGYYFEQRGLVAVKGKGQLMTYYLQGKRDSVTGEPEKSMMEDPCEADATDALLSNGDATASQRALQQSTVAGAGSGNDVARPLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCK7</accession>
    <name>A0A194RCK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCK7"/>
    <dbReference type="InParanoid" id="A0A194RCK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="8004" checksum="581CD0EE2208DB0A" modified="2016-10-05" version="1">MNPELGDTHHPSAPRQRQPPPEPRPRQPPPEPKKATGQSPPQPRERQPPPKPRERQPPPQPRDRKPPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDM7</accession>
    <name>A0A194RDM7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDM7"/>
    <dbReference type="FunCoup" id="A0A194RDM7">
        <property type="interactions" value="1900"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDM7"/>
    <dbReference type="KEGG" id="pmac:106710388"/>
    <dbReference type="InParanoid" id="A0A194RDM7"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000008">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="284"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="485"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="437"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="672" mass="76581" checksum="A53F9865624D5C26" modified="2016-10-05" version="1">MSQEISCGLEYISTPDLQACLTEALHSNYSFIVANVVHPRFRRSYIPGASKIGGFTRSDMVLSPQDWTSRIVAKISPYICVDSESPVVRQRHEDCLNEELSYCRGLGVPAIMLSLQSRNTNNLSRILQTYYETSHHPSLIWASVPMYCTRNARRNNQDDDDECEEAWDETWHWWSKFHERLEWDKRVGVVLEISADIPPQNILKRWLGEPVKAIVIPTSIFHNNKKGYPVLSRAHQQLVVNMVEHEAQVIVSGARRSNIEYYLQYLFRLWQRRPYKADDPMLSYARGWEDYLQTPLQPLADNLDTHTYNVFEKDPIKYDQYQRAITQALVDIKEKRLNKDNKEMMNELCNDVKEFSVSNEKNEMGHGDCLQETESITVMVLGAGRGPLVRATFNAADITKSKVKVIAVEKNPCAVVVLAAQVREVWRDRDVVVIPGDMRHLNLSPKADIIVSELLGSWGDNELSPECLDGAAGLLKPDGISIPKEYNSYVAPISSPRLWAAAKVASSSSTNQKEKNLETLWVVYMQNKHDIAGTKPVFNFKHPAKGTKDHEGDELKDYRGLPLTDNRRSATVSWVVEQDNVMHGFGGYFDCSLYGGEMISIVPSTHSPGMISWFPVFIPIKTPLRVHKGETITATFWRCVNSRRIWYEWIVEVGNYTTPLHNANGRSSEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG60</accession>
    <name>A0A194RG60_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG60"/>
    <dbReference type="InParanoid" id="A0A194RG60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11860" checksum="E24280D78BA5A0D4" modified="2016-10-05" version="1">MSNSLSRDKGDLIVDYNSLQAKVEEAYRHKIQTHYKMFGKLIILFAILAFAFARPQVYPGYSYGTYSGASYPGYYGYSGYSNPYPYGSYGTYSASPYSSLGYGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGM2</accession>
    <name>A0A194RGM2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGM2"/>
    <dbReference type="FunCoup" id="A0A194RGM2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGM2"/>
    <dbReference type="KEGG" id="pmac:106710839"/>
    <dbReference type="InParanoid" id="A0A194RGM2"/>
    <dbReference type="OMA" id="CFEVLSN"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="585" mass="64701" checksum="D44EF9A3FD7E589D" modified="2016-10-05" version="1">MSNLYEKLPCKEGSRPYKCVEFGTKVSLKLNNLRKDGRFCDIDLISGSTKVKAHRVVLAASCEYFDAMFSVGLEETHKGHVILPNVPPGILPMIVDFIYTGEIIIDKATVQHLLVVADMLQLRELVSGCGEYLKRELHPSNALGIYRFAESHNCMSLAEEALAHAQVHWNLVTKGEEFLELPLQQLVTLLSSEELKVDNEAQVLYPALEWLEHDPASRRRHCFEVLSNVRLPLILPQILDDALKTVRDPSIAVALKTVRVDMKTGRGALVSLAAEPRARSRRVLLVAGGSCHDNNVMPSFVTDNILSTVLKFDLYKREWEELAPMDIARIQPGMATMGGRVYAVGGEQGSQILANGEVYDPQNNKWSDIAPMKEARCEFGLTGWNGHLYAFGGWVGSDMGGSVEMYDPINDEWTLIGRMPEQRFGMGVVTFEGLIYVVGGCTHSWRHTRDLLCYDPSTRTWRTLAPMRHARSQAAAAVLDNHLYVIGGNAPQRTVLASVERYNFDDNTWEEVASLRQARAGCAAGAADGVLVAAGGDSESDDGQRAFYRARTTLASVEVYEPAENVWRPAPPLPHVRAEAGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHJ5</accession>
    <name>A0A194RHJ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHJ5"/>
    <dbReference type="FunCoup" id="A0A194RHJ5">
        <property type="interactions" value="1596"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHJ5"/>
    <dbReference type="InParanoid" id="A0A194RHJ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000113">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.400">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="624"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="712" mass="76716" checksum="4E57D2E968C0C04F" modified="2016-10-05" version="1">MLNRKRFILSKLKLKGLCYCRLLSTQTNVGEIEVPFSNGTTLKLSTGRYARFADGACVATLGNTSVLATVVAKAKASAASFLPLVVDYRQKAAAAGRIPTNFLRRELGPTEREILTSRLVDRSVRPLFPQDFTSDTQLACNTLAVDGTNPPETVAINAASAALALSDVPWDGPIGAVRLGQIDNELIVNPTRRELERSSLNLVVAAASGNLVVMLEGGANDVLQQDLLKAIKLGAKEAQHVVRAIERLASAHGKRKRAYAAPPQLPGDVADALRALCTMKIREILSDFSHDKTSRDAALAELRQTAVAQLRDAGDPALLVDCFNAHLRQTFRDLIFETDVRCDGRALDELRKINCEVSLYEPLHGSALFQRGQTQVLCTVAFDSPDSALKLDPLTAITRYTRVLAPSYHPLPPPPPPAPCPDRAHPAGSSSMASVCGGSLALLDAGVALSAPAAGVAVGLVSRYQDGALCDYRILTDLLGIEDYMGDMDFKVAGTKRGVTALQADVKTAGLPLKVVMEAVQRACDAKARVIDIMNKCIDRPRQDRKESLPVTEELTVEPHERSRVLGPAGINLKRLYVETGVQLSALDERRFSVFAPNAAALAEARARLAGWLSAERAPDLEFGAVYTARVVELRDCGVMVSLHAALPPALLHNSQLDHRKVQHPSALGLAVGSEIHVKYFGRDPVSGQIRLSRKVLTSPPPATPRKLDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHL8</accession>
    <name>A0A194RHL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Potassium voltage-gated channel protein eag</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHL8"/>
    <dbReference type="STRING" id="76193.A0A194RHL8"/>
    <dbReference type="InParanoid" id="A0A194RHL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="235" mass="26467" checksum="926CBC881D02BEC3" modified="2016-10-05" version="1">MPGGRRGLVAPQNTFLENIIRRSSSQPDSSFLLANAQIVDYPIVYCNETFCKMSGYNRAEVMQKSCRCSWMYGELTEKEAVQRVDRALDHHLADQFEILLYKKNRTPLWLLVHVAPIRNERELVVLFLLTFRDITALKQPIDADDPKGGLSKFAKLARSVTRSRSVLVSALPALKEPARQSQLAHVSTNAHHVRTIRTPFFRFSGLVAAPRHRRTSPPPHLAAAATDDPTSPQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHP1</accession>
    <name>A0A194RHP1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Immunoglobulin superfamily member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHP1"/>
    <dbReference type="STRING" id="76193.A0A194RHP1"/>
    <dbReference type="InParanoid" id="A0A194RHP1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="131"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="389"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="850" mass="96704" checksum="1C9AE2972D6B4DDC" modified="2016-10-05" version="1">MFRLQFKNAHLTPEEEERRTASCARPWERPMPSDSPVILGKKHLDIIKQIGKPVKIPCEIQGEPAPEIHWSINGVGVEDTEPYKIYRDHSLTFKASIETMGKYSCEGVNKLGSIKKTANVSVFEPVSFGVPKELMIKIRVGRTLDISCPVKGYPTPKVRWEFYSINGTIRRTLSEKAQLIISAIQASEHGYYVCVAINPDGEEKSLRYVVNVEVPPSIIPEEKNIVAVVGDIGIRIPCNSYGDPKPTISWIYQGQPLATGNEYYDMESDRTLIFKNVKGSVAGMYACVAESDLGKVFEYFNVKIEAFPRTSNIVSEKYLEVSQSAVVQCNVPHSATDQIRWYKGRNVVAYGDLIFNKYKSSRSGLYKCRVSNYFKSVTGAMRIKTGFKPRFAYPTIQHDFMFYEPNLCLNCGNSANPKAKISWWKNKMKIVYSTDTYCCKNVVSSIGEYECVVENDLGKISQKFYVKGNDCLIDIKEEFDRHHPLVLNRYNKLSDFSVIDGHLAIPMGHSAQFFCQGSFNKFTDSSLKAECVESQIFKINGEQVDFSKLKCKEALQPVTINKNEDCANGNGEIFRIGINVNEFLEVYHVCFHRKLKIPLYAEYNLKASAAGVSCASPEKWFNSDVLNYNKDEMYDCKQQRNHLTAIIGRDMPGKEDECFGSRQLVNEKDLPAGFPQMLTHSYLNIIPQWNSDSMKNWDILEEILRTQVKKRHRSFTRSNVFIRTGVSQNFLLPIGKSKRYKDIYIKDKAGNKFILPVFLWKVITDELSAATVVIIQVIIPGSLRGDDIKNYEICTNQCDKIQWLDGIDAEYLKSGYMLCCSINDFEKAFPYRVSFSMGYKKILSIFTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHX4</accession>
    <name>A0A194RHX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHX4"/>
    <dbReference type="InParanoid" id="A0A194RHX4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="408" mass="47377" checksum="A65441D9D28B200C" modified="2016-10-05" version="1">MIYLTETTKGDKKSIYLFSVRSEEKLKQQENTETNTWDDYECFKISQENFFPAKVIDLDIQKIIITRFLNFYVGGKVPKGLRVSDLLFAVISIIPLTSDTEEFIWHENEYRDDGFLFFLTPEEKLNSDFKNIAKKANKTYIDTIEDNNSNIIESDSNKFSDYESKNDVGAPSCDEKAPKCEEQDDTSTSDNNSDDNLKKTSSYVSIKWRGLKTSFASSCEITSEQYGPVENSAFISSCNKLLIEWDESKESRIIIKWFFDLKDEEINDSMEQVRNFILKYMKKEECFTYHWARYFDSTQFEYLSCSKSYATAVLLAVFIEKLMGKSDVWRSGWVRMQQVDLDRYKQLGEQLYKQYECKTKGTLQMFFSWLSSETICDGISKPILLRDLLQSEHTVSLKAGNSSAVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIM7</accession>
    <name>A0A194RIM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Poly(A) RNA polymerase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIM7"/>
    <dbReference type="FunCoup" id="A0A194RIM7">
        <property type="interactions" value="1567"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIM7"/>
    <dbReference type="InParanoid" id="A0A194RIM7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF133">
        <property type="entry name" value="POLY(A) RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="172"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="601" mass="68934" checksum="96BF883EAA321FFC" modified="2016-10-05" version="1">MTVFFQTGKFSIIRKCLNAPICNSLFIRNYSDPVKKFKSFSDVIAQRKAEARRSLVVQVNSETSFNELYGYCSKYASIKDIHHYRNSEKEHFMLIEFETEENVKEVLKACSSHQKDVDVMPIESPFLWFRAAVNKKEKLSCPSTKTLATKDGIEPVDNDLLYEELLNCETVTQQIQHLYERTKLNDLGVRLRYMVARQFEVIFKSLYANVAVQPFGSSVNGCGRMGCDLDLVLSNVLTEDMSDTRRRLVYQEKREEYAGGGRGGARQLELLGALLELRVPGAGAVRRVLAARVPILKCTHHLAALHCDLAASNTSGVYMSELLWQFGALDPRVRPLIFVVRHWASAVGLTNPHPGRWITNFPLTLMVLFFLQQKRKTGFILPSLKVLVDRAGKEDIRIAEENINCTFLRDLNKLPHEEYGQSGEDLHTLLLQFFEFYAQFDFQEHAISINRGVPIRKPNALPLYIVNPLEQAMNVSRNVSYEECERLRAEVRNAAWLLEEGLEGKKGDDWGVLRLIERKDSRGLKQLLRVGNSHRLVSVKDLFNEDDEDVPITKSKKTDAEVDKSVKEMRRVTVEKKEQKIKFKNSQIANEVYRIRRNKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJR2</accession>
    <name>A0A194RJR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative uridine nucleosidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJR2"/>
    <dbReference type="InParanoid" id="A0A194RJR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="707"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="833"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1494" mass="169354" checksum="F7109FD222210394" modified="2016-10-05" version="1">MLQRRIYDMYDNVLEIPDEVEDLPRAEPIVPGHTLLRPALGMLKSSVMFPQKDYRNFVYGNIDNLGITFGITKRHSNCSSPVMRISSGVDDHLGVPAVRSSFPFITNSNVVKLNIRRFHPRRSSKSKSKYRLRDKYYDKSSSDSSAVDESESHERNPGNPYTVHKNHYKQNWMRNHVMTGDHMNVNPYAPLINNYGPSGAALIFGRKWWYFNQAVLPCNGVSLLQQLEHIARRRLESRGEHPLTRRVFFSFDRGEVTNIAGVPHSPKHLPIAEPILPGHTLIRPALGMLKSSLKFPHIDFEDGSGVYGSVDNIGLRYNGAIERVMYSDFRRRASDYLMVVPEKNIENPSKPRFKLLSTVLDLGNKDTIKNLLQQLQRLNQQGPIRLISHPPPTIWRPTWGQSIQQRNIPYNLATNAGKSNQPRYITRRCQKFGILHHTQQSFSCHQNAQKNIDLTLDNIPSLQMPRSTSSIGVKQVENVEVVIEKIPFNVRILPSRRRRLESRGEHPLTRRVFFSFDRGEVTNIAGVPHSPKHLPIAEPILPGHTLIRPALGMLKSSLKFPHIDFEDGSGVYGSVDNIGLRYNGAIERVMYSDFRRRASDYLMRENLNLNNKLKEDLPDSNPVEEPNSEEDKPEDKDILENNAMKQKFVDMIKSMNAYNHIKISESAPDYATFMPAHVSNNLRDWWFFNERFQFLSSSEDTVPGPKLVIDHDGGADDAMAIFMALQYQKYFGGNQVIALTTTHGNVNEPQVFNNTQKFLNIVDRRDVFIYRGSKFPLVKGIESDYYFGMDGLGDSESEFLEYEPIEAQSNSAALALIELSKKFEEDIVPGPKLVIDHDGGADDAMAIFMALQYQKYFGGNQVIALTTTHGNVNEPQVFNNTQKLLNIVDRRDIFIYRGSKFPLVKGIESDYYFGMDGLGDSESEFLEYEPIEAQSNSAALALIELSKKFEGELIVVALGPLTNIAIAVRLDPEFISRLLKLYVAGGHIYSDIYNEPEFNAEMDVESYYIVLQNSQPDIVTLVPFSQVYSSHNISREWRVSTLGSIPSELIRALNVFEQKSIVKSEEWILLDPVAMAIVLNKTQIIEEWRYTYNSIDLCGSITSELIRALNVFEQKSIVNSEEWILLDPVAMAIVLNKTQIIEEWRYTYNSIDLCGRGRGTNTNNFTSNEYFNSKIVYKVKEEPGRPKPKIIIDNDAGGDDAMAIFLALLYEKHFDGPKLIGLTTGNGNTNLENVCRNNQRILKAAKRQDVPIYRGSQASLVVTPSVTDYYGKDGLGDCGLYMSGLAPLKEQSAVTALIELSKIHEGNLIVVTLGTLTNVALAIKLDPDFLGRLKQLYVAAGHIQNEENPDPEFNASMDIEAYHIVTQYATPDKVTIFPFSQVKSCLNFTRNWRLESLGKIKTDIMRAQNLFEKIAIDKNEEWQALDPAAVAVVINEDLVDEYKYSKNGIITCGEQRGINTNYFVAKEDANVKLIYSVKRDEYKEFLLNVFSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMM7</accession>
    <name>A0A194RMM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMM7"/>
    <dbReference type="KEGG" id="pmac:106720985"/>
    <dbReference type="InParanoid" id="A0A194RMM7"/>
    <dbReference type="OrthoDB" id="8194217at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="17057" checksum="D1A6C71F6F12CF46" modified="2016-10-05" version="1">MCLAKDGSPSPQKEAVSPRSPWKKLLNRQSSKPKLPRKVTTSTRVNLNKCWTKLGELISNASPRADLPSQKTVDPEEPLLVPFSEYFYPVDPVKPVPVEDSDNAENQNILNNNRFELISEALEINDNMANEVREICYSATKNNCFVCKLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMY4</accession>
    <name>A0A194RMY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMY4"/>
    <dbReference type="InParanoid" id="A0A194RMY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="40" mass="4588" checksum="7A1F271987189751" modified="2016-10-05" version="1">MTAHWRVFGLFTWITMETAGLPLPGYHYIAPNHIVKAPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNZ7</accession>
    <name>A0A194RNZ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc carboxypeptidase A 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_12556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNZ7"/>
    <dbReference type="STRING" id="76193.A0A194RNZ7"/>
    <dbReference type="InParanoid" id="A0A194RNZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="781"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1081" mass="121820" checksum="BABE9BA7083D5847" modified="2016-10-05" version="1">MPSEDIENMAFGFSIGYQKSGKLVIGAPYSDLNGRVYICAIEDIMKNNGVCEKANIDVEGLTVNSTREDYPDRHYCLGASITATDDYFLTCAPFWKSSYDKIQPVVTSSSYGTCFIYNGTAYLYNGPYEQFIKDKINRRSALASGTFFYSGINQTLYAFSMRTDDTYGKISFLRYKNQKLYLVPRISIDFEAVNTMFGSAMLGADINSDGYTELLVGAPAFYEDDAYETGALYIYTGGDLATIGSRNRTRLIVGNKVGSRFGSAIASTDVDGDGFPEVIVSAPYEDLGIGAVYIIYGKELNKKCLKGNDFKETMYLSQFVSTQRIQNVDFKSFGVTLQVINDVDNNGADELAVGCPESSRVIMYRGVPSVGVTVSSHLVGDQRILHPLEICILESIKYKLNAMIQINVKNISIIFKFLSLGVVIMAAVFWTGAEVETRSKDNDEQTMIGGAIWTQIVVTIGLIISTVVDDHIQPFVEGYFLFSAMALLIVTGVILIINNGSILWRRVRAIIKWKKQIFIKEYKIFQTSVTTDCVRQNTSEEVTYVCMLTLEPNSIFKIIPTTIIMENDVEKYRVGDTLNISSSLELYLLPTEEKKEFSLTTVIKYHKELSIGQNKPLIIAIAVIVALLILALVIYILRKIGFFKRNTKKKLIQEKREDELRKSVKRMAPSGANDASTSSGSTGLQNKALESTEIPFKSECSDIEICEEDNLIKTREVEETLSYAETRDGGEFVVAPHLEDLFNKIVAQENLKATMIYDDISKIIQSEKSMLRGNKEFSWTAYYDIDDIYKYLTNMSKSYSNWSELIVGGKTYQGRSILGLRINTPSQEYTPKPVIFIESGIHAREWIAPATTTYFINELLTSKDANITALRDQFDWRIFPSVNPDGYHYSYTVDRLWRKTLSKTTNRCFGADPNRNWDYNWGQHSSTHNPCDYQTYAGSRPFSEIETRTLASYIQSIDNMVAYISFHSYAAMLLLPYSDSTEHVHNYDDLVKVGQSSLDYGYKVNKDKRYEGPGTAAEILYKASGGSMDWVRHALGTPLVFTYELRGNSFHWPPSRIQEQGDEVTQMMLGLFTEANKLGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP10</accession>
    <name>A0A194RP10_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maternal protein pumilio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RP10"/>
    <dbReference type="InParanoid" id="A0A194RP10"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="236"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="508"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="590" mass="63446" checksum="3140FA03D82D5F3D" modified="2016-10-05" version="1">MAAPWGMYPGLVAPPAQQQAQQPRRPLTPQQGEQQVNGQGQYVIPYYDPGSIVLGGRNGTPLRLVSPGGVLAPRQYPAAHAAATPAPPAPPTAHQPPQPQPQQTGSVWAVAGGAATRRDSLEFGGGGPAAALQEYARKWGPSPLSPPLALGPVGLRPVSAAPGAETAKYRAVSSLAQGLTSNGMFGSSSSLLSKLSGVGTISELVGGGVGGVGNVGVGGVGGVGVGALVGDKPPAGRSRLLEDFRNNRFPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATVPEKQMVFNEIIGAAYSLMTDVFGNYVIQKFFEFGTTEQKTTLAQKVRGHVLALALQMYGCRVIQKALESIPAEQQQEVVRELDGHVLKCVKDQNGNHVVQKCIECVEPTALQFIINAFAGQVYALSTHPYGCRVIQRILEHCTPDQTAPVLAELHAHTDQLIQDQYGNYVVQHVLEHGAAEDRARLVAAVRGKVLQLSQHKFASNVVEKCVSHATRNERGLLIDELCGFNDNALHVMMKDQYANYVVQKMIDVAEPTQRKVLMHKIRPHIGSLRKYTYGKHIIAKLEKFFMKASELGPIGPPPGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPR7</accession>
    <name>A0A194RPR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0668 protein C10orf76-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1193"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPR7"/>
    <dbReference type="InParanoid" id="A0A194RPR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="629" mass="70928" checksum="ED1B431FB5D99549" modified="2016-10-05" version="1">MAMRKRSGSGSKRHLKEKVVQIYESFFRGEDLTSDNPTFWDEFFLLKPKIPQLEAEIHKLTVEQLNNMKENMNVLVTQCIEMLGQEHHIRLVYALQTFSALLTTMYQRAAQEPSINIKLVLLGNENYKMQKLLEHCSAVLSGDVPDSLKSMVIKLLLVIATGVDNIDENPLVEYLMLNSLFDPLIQLLCTSTERQHHGYDVVLLLMFLVNYKKQESANPYVVKLSILDDELALNGYGQVITAALNDYVMSTFGGMHGGGNASGWLSSLTSMVGGIFLTSEDTQPLVRGHRTSGGEEGMLLALYEAAHLNRNFMTTLAHSSSAAASSAPPSPPATLPPHQTPPNLAQIQALDNDQPTNLLVQLYRLPMRHRKIVPEEPPSQPLASTLIDLLVEFMMCHLLKKFPGELYSLCVGVLLRLLSYQKRGRVRLSRDWRPLWAALIALLKFLVTNENTLLKRHNIFVMAQQVVNIFNLFITFGDTFLPTPASYDQLYYELIRMHQVFNNLFYMALRYSTGDGEYKAEALRLANCLVNVRAIIQHFSPKIDSWLNSQNLSTPTEDQILEIVRKNYDSLILKLQEGLESYERYSEREHRALLVRLVRAAAGGARAASDAEALHRHSAALLSHYTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPW8</accession>
    <name>A0A194RPW8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPW8"/>
    <dbReference type="STRING" id="76193.A0A194RPW8"/>
    <dbReference type="InParanoid" id="A0A194RPW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7645" checksum="B22713C06FFD103F" modified="2016-10-05" version="1">MLHIFEKKFIYMCEVNPHWVSMVDYVLVTTNLGAGVLGLMLHSTYNHEVMERITKVNENGKMKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQJ0</accession>
    <name>A0A194RQJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative multidrug resistance-associated protein lethal(2)03659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_06524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQJ0"/>
    <dbReference type="InParanoid" id="A0A194RQJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF324">
        <property type="entry name" value="LD17001P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="819"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="98"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="447"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="801"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ19664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1393" mass="155809" checksum="A651A08BDE96EB02" modified="2016-10-05" version="1">MDPGHYDTNRQQNPRESANILSKLCFWYTRGIFVKGHIGELTISDLYRCTPGHRAAQRGDTLGASWKYQLTKRESGGKASLLKAIVAVYGYKFIVGNLIFSLVESTIRLSIPMCLEGMINYFSSSNSGIPESHAYLYAFGVVGLQLVNAIIMHPFFVWMLAMSMKLRVACSSLIYRKLLRLDLTVGGQASEGLAGHVINLLTTDAQRFDMAILFLVDLVRTPIESAFIVYLMYRQIGVSTLFGVAFLLLFIPLQGYLGTISSKLRHRTTVLTDNRIRLMNEVIQSIETIKMYAWENAFSKIIGEARKQEMKILKKMCWLHAVMTSCVKLNTKVAIFISILSFIYFDNDLTAAKVFVIFYYYENLKYTLVDFLPMAIAFVLEAYVSVKRMQEFLLLPEVNNNDGVDLLRIHEESKPVHKNGVYEKVHTEPPEEEIELKTTSVKSDVLVRMENFSVRWKSSGDEANNIPALTDINLIIRAGTLTTVVGAVGAGKTTLLEAVLRELTPCAGTLLVDARLAYAAQEPWLFDASIRQNILFGEEMDMQRYKMVLECCQLQSDLEILTHGDRTVVGERGSSLSGGQRARVSLARCVYQQADLYLLDDPLAAVDAKVAQAIYEKCVRGFLRDRAVVLVTHQAQYTRHADNMCVMRDGMIVAQGTYSELQETLLEFERLVENVEVNQGTQKKAKENDEKLKEENAMRLKRTISVTSKISYDANPIDADYEGEVQNKGTIDSSVYLAYVKSGGSAFSMVCLFSLFICAQLFYSSTDVWMKEWVNLEESNNIYYRNMTQGNLTSNLTFPDVDTIQNPSNYLQLSREQCIYIYGALIVVCIVFTWNKLVVFYNICIKASINLHDSMFRGVTNAPMWFFHHNPSGRILNRFSKDIGQVDSSLPVTLLDCIGFFLEIVSVLVVVCLANWWLLLPTAVVAFLLFLLRELFLGTSRELKRIEAIARSPSLNQAAATVSGLTTIRSCGSRQRVLAQEFDKLQDLHSCAWTLVLDTNQAFGFWMDMVCCLYLVFVTFSFFIFASEENRGGNVGLAITQAIGLVGMCQFGMRQTADVENQMTSVERILEYSNLPAEEPMEVDMKAFKEQYPNLDFDKWPEKGEIVFENVFVEYEKPPKKEKEGSAVGCEKAEEPSYAVRGVSLVVRAGEKVAVVGRTGAGKSSLVAALFRLARVSGRVTVDGVRAEACGLRAWRSRLCALPQRAALFAATLRDNLDPERRYGDAQLWAALERVRLRAAAAGLPGGLAARVGDAGGTLSAGQRQLLCLARAALAGRAVLVLDEATANVDTETDEHIQATLRTTFAQATVLTIAHRLNTVMDYDRVIVMDKGRVVESGHPFELLTSEDQRSRGDENHLNRHNADNPGIFKSLVQQTGPETAAMLHKMASEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC94</accession>
    <name>A0A0N0PC94_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC94"/>
    <dbReference type="InParanoid" id="A0A0N0PC94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="287" mass="32247" checksum="8C5153400DE22684" modified="2015-12-09" version="1">MLLLNRYTYKKQRAFASGKVLWYCSSRIAKNCKAFAKSVGDIYIFGGVQHTHPPPGYKPTDRPMEPDNEKYVGTSRRGGEILHYQGQVFNLRTKSAAGKKTWCCKYYYNCAVICPVKIKTLGDDNENLNLIITDITSEANVQNESDDDVIEVVRDEAPIEILSDDEETELERSKLVTAVDEFLFADLPARLENSIDKAKNSPIDPLFSNTYLESSIDVTDCNTAQNEVTNNLEDEERSTIVNVTDLLSDNQKNEEIGLNLPHTENKHIDNTSIPNVPNEGSTDNKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCJ1</accession>
    <name>A0A0N0PCJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endothelin-converting enzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCJ1"/>
    <dbReference type="InParanoid" id="A0A0N0PCJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="35146" checksum="3BB097700ACDAD4B" modified="2015-12-09" version="1">MFKLEVLTCRTLPCDDDVFFALVSVALAKPKPGGLFSSFDHGFSSLDLHQPALTLSQPTYTVAQPVVHAAPVVHAAPVVHAAPVALAKPATSYSSFQQVVHPVQVAHAAPAVVHAAPVISQPIVHASPVVHTIAQPVIQKYLSLGSYGGSYGGYGHVTMNAWGNEGDDAMGPSVSRPPSVATVTRHPPLKNGGELRETGYLIGIGSRTARFRRKHRKKLYWLILLILLFTIIFMGIMITLIYKYIFKPPPNICMTKECLRSAANLALSIDKTAQPCDDFYQYMCGNWPKNHPRPDEYISYDWFSDQETRVYAAVRDFSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDI2</accession>
    <name>A0A0N0PDI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trypsin CFT-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDI2"/>
    <dbReference type="FunCoup" id="A0A0N0PDI2">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDI2"/>
    <dbReference type="InParanoid" id="A0A0N0PDI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="7" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857232" evidence="10">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="200" mass="22272" checksum="D78049612361D911" modified="2015-12-09" version="1">MRLFYVIIFLIVGLTSVLAFPGKQQRIIGGSITSIDRYPFAASLLFSWNLQQYMQSCGGTIITNRAVLSAGHCFYGDSAARWRIRVGSSWANSGGAVHNTAQIIIHPNFDYEHFDSDIAILRTATPFVYNNQVRAASIAGINYNLADNQAVWALGWGLTAVNGTASEQLRHVQIWSINQSICKSRYNELGERITENMLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDL0</accession>
    <name>A0A0N0PDL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger Y-chromosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDL0"/>
    <dbReference type="STRING" id="76193.A0A0N0PDL0"/>
    <dbReference type="InParanoid" id="A0A0N0PDL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="52140" checksum="FB2DE618D6571BE4" modified="2015-12-09" version="1">MLYFCDFKKHPYRIKMESVIKSEAEKNEEGEETPTDSPAPSGPLKFISVTSSMLTEEQREMYESVLSTWKPVMFPKRTKQYICQKCSKEFKNYQNLYLHTTRVHSSEDSAVICDICVKTFKNKHYLYMHRMNKHYSESEKCYCQFCFQEFRTRRALHMHVKRAHPATLPEIKCPVCGKEFSVPYKLRHHMDSCHIDDKDKYQCPICQKLYKTHLNLNRHLHFQHSQVERHQCVFCPMTFKSRHHMKRHILNIHPPLESKVQCPECLKEFKNDQYLKEHMQVHTSFESKVKCDQCDKYFHSAVRLKKHKKIVHPDKPKLRCEKCDKEFAHAHYLKRHNNSVHLDVDETKYEHECPQCNKKFKIKRYLNNHLQRHEQQHLKRISQMVKTVMGDEHKAGNPPKRRGRPRKVHKEFEFIKCEPVSSSESESEDTETESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDM0</accession>
    <name>A0A0N0PDM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cadherin-87A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460146">
        <property type="protein sequence ID" value="KPJ17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Cadherin-domain_protein"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
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            <end position="129"/>
        </location>
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            <end position="240"/>
        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="378" mass="42214" checksum="6B40DC9B555318BB" modified="2015-12-09" version="1">MDVGALVSWFSVRSDGEVSVAGVLRRNMAAVVTLPVQVTDASAPSLQRSYGEFGEVTYNISGELSNLFTIDTNTGMISIAEGAVIDRENITDIYLRAVATDNAPPQIRKTTSVPVHIKVVDENDNAPVFTQKVYKSTIAENLQLEPPAAILQVLAEDRDEGDNGKVQYSIEEQSEPAQADYLITTIKATDADSGDNGRVSYYLKVDNRNVRDTPEFSLDTDTGELRTKTFLDREHKAEYQSLPGTNGFADRDNGRVSYYLKVDNRNVRDTPEFSLDTDTGELRTKTFLDREHKAEYQLVIAAVDNGTPAQFESLRLLTVVLSDEDDNTPRFTQRHYQLTLAENLPPGIIVGSAHQFFILHHLLRNNLFRPICRQTDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDR1</accession>
    <name>A0A0N0PDR1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trissin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460127">
        <property type="protein sequence ID" value="KPJ17577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDR1"/>
    <dbReference type="InParanoid" id="A0A0N0PDR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8963" checksum="026CE5EA22E87837" modified="2015-12-09" version="1">MLVSGLSCNSCGVECASSCGTRRFRTCCFNYLRKKRSDAIEIPSHIPDVEGYNAYTPEDLDWWNSILDNGRSKFDFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF04</accession>
    <name>A0A0N0PF04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459752">
        <property type="protein sequence ID" value="KPJ20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF04"/>
    <dbReference type="STRING" id="76193.A0A0N0PF04"/>
    <dbReference type="InParanoid" id="A0A0N0PF04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="27521" checksum="18EA9A7528B84329" modified="2015-12-09" version="1">MACVSAVEEQLPFASSWPSKLGQRVGEQSSYITRRCRPIHKQLPISFTMKVFVCLLALAVVAKAGYIGGGGGGWSGGGGGGYGGGGWSGGSSGWSSGGGGGGGYGGGHGGGGQVKIIKIITTGGSGGGGGFGSSEVDSLPILTELSHRQWVDPATTIFVGCTHEWVGSTSQIRPHKEDRSEVEAIPRLENAALCDEVAKIQENILIVKDERKFLLRKLLELENESETQQSRYETITHNGSKSKPKKRKSLEDGGKNISSNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFG4</accession>
    <name>A0A0N0PFG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histone acetyltransferase KAT2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01001732">
        <property type="protein sequence ID" value="KPJ20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFG4"/>
    <dbReference type="STRING" id="76193.A0A0N0PFG4"/>
    <dbReference type="InParanoid" id="A0A0N0PFG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="11241" checksum="EBAE397197C9AED7" modified="2015-12-09" version="1">MQAPRDEAAKLEEQRKMIEFHVIGNSLTGPVNKQTMLWLIGYFKKQGFSKDIKLPRAMYQGYIKDYEGATLMHCELNPRIVYTQFTSVIRRQKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFT1</accession>
    <name>A0A0N0PFT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01060394">
        <property type="protein sequence ID" value="KPJ21611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFT1"/>
    <dbReference type="STRING" id="76193.A0A0N0PFT1"/>
    <dbReference type="InParanoid" id="A0A0N0PFT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12567" checksum="42BBC17D14E4F2E2" modified="2015-12-09" version="1">MTLNFLVLGMTLNFLVLGMTLNFLVLGMTLNFLVLGMTLNFLVLGMTIILWRKSNKLALRLQVRCGEEVEAGSAAEAALTLQYRYRNTVPAPHEPRDHTLHATLMLQLGHVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5P8</accession>
    <name>A0A0N1I5P8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5P8"/>
    <dbReference type="KEGG" id="pmac:106716029"/>
    <dbReference type="InParanoid" id="A0A0N1I5P8"/>
    <dbReference type="OrthoDB" id="7339438at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="45406" checksum="68B749810FBFAE42" modified="2015-12-09" version="1">MDSYYVLLTLFYAVQSNNIDIDKLEFCKNLNCDEWPNIHVCGIREESDGFRLKLFESECQLLEYGCKVDNDKTYGLINLEYCKKAFIQDYYPNADLNNKTVEEHKGKTDECTKINCTLTNKEKRICGLKKYGAAYKVRIFKNECELKKHNCDTKSEFVETDLFICNSLLSNDSTSSNDNPIKSNEEPKDIILNNIVVIDGNMLGYKNNINDTIETFFAATHVLDMPMREISPDFVNEITRRRQIKIAGPIKVFQPWTTIPSNITDDYLHSPTLSSCFHKCPTKCPDTYAPVCGVPGIVAREPSLMFQNHCFMDVAQCKMRWEDKSPTAISSSYIESSFMFCLGDQLNAMYRFLPLVRTLQHMGRLKKKGRFKYKLRNMRFFNSLLSRDPKLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6E3</accession>
    <name>A0A0N1I6E3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Epsilon-sarcoglycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03297</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sarcoglycan alpha/epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6E3"/>
    <dbReference type="FunCoup" id="A0A0N1I6E3">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I6E3"/>
    <dbReference type="InParanoid" id="A0A0N1I6E3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008908">
        <property type="entry name" value="Sarcoglycan_alpha/epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048347">
        <property type="entry name" value="Sarcoglycan_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048346">
        <property type="entry name" value="Sarcoglycan_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132">
        <property type="entry name" value="ALPHA-/EPSILON-SARCOGLYCAN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132:SF14">
        <property type="entry name" value="SARCOGLYCAN ALPHA, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05510">
        <property type="entry name" value="Sarcoglycan_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20989">
        <property type="entry name" value="Sarcoglycan_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873769" evidence="14">
        <location>
            <begin position="33"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="15">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="60746" checksum="5E5DC9B5090C6B6E" modified="2015-12-09" version="1">MALLALSTFRGAIITKMRIVLTQLLLAAVVYSQNINNAVETEMFAVPITPNLFNWTYQEFEEQYRFHASLKGKPELPSWLRYVYSSRHHSGFIFGTPPRGTESSITLEVIGLNRQDYETRRVLIVLKIQPKENMARHEVELKIDNLNVEDLLDDHRMTRLKDILRMKLWTESKEDLYPTFLSSAIDLGARLPLKPSDGEGLVVRLGSSMPFSSELKRLREEVRPLSRLPSCPREYKRTTVERLFRDAGFTLDWCSFELYNTIYKPRSTVHLEYLTELPNTSRISSTRVLDRQQWSAPERRALPQRGVARQLVAAVAPPLLLLCVAIAALTAVLCFRYAAMTDPESEYFLENIYHICIDYREKRAHKTGRVELCRYGTGNTEQTQINDNNSNKSLGVSPNNSLVRPYSPKSSTNLAGSYNRPQPPPYIGSTTNSLHHRKSGNTTTPSTSGHTPEHSRTLALEESLKLLNEANITGNYDGIPKDPIIDINDGSEDYVLVKPDFIQSKPDTIGYNSIKPDLDDINVPELAKYGVTGIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8K3</accession>
    <name>A0A0N1I8K3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460389">
        <property type="protein sequence ID" value="KPJ15422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8K3"/>
    <dbReference type="STRING" id="76193.A0A0N1I8K3"/>
    <dbReference type="KEGG" id="pmac:106710426"/>
    <dbReference type="InParanoid" id="A0A0N1I8K3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="541"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="699" mass="77157" checksum="BE0B31D674E89149" modified="2015-12-09" version="1">MDKKNKKKTVIKRKADDPNESEKKKIMITRKVEEEKDKVEVVNQVVEVPVEQGQQIVHTGQIVEGNFEQSVFVNMKGEPVQLGPNTVILYEQTNGTPANFAFGGMWTMDSSGRIVMAETIYDVKGEPDEETATFVQNSSEVTNQPVEEQPATFQQFELSTNSQVEGQEYEVAIIENPGDGTERSTDNQVITTEAQLVATGPGAVRWLNQKYDFVVRKLQLNYDAGVKLMYSESGCIQCVYFTTPSMQLAFNAVPQFLCIETGIEFNSSLSSVTGSNNSSIKHNVTLFLAEDGNGKSVIVSAGISTLIGEDLRWLLETFKSCNPAWRQVRCVVCDPTKSQEEVRSEFPNAHVTCSIWQASCAAAKLILETARREDGTAVLLSTLSHEDLATRCKAYALATLRGDHTPVQLQALKRSIIGTGAGSMRLLETVTKCSGAITKFDQWLQSENYTNILHKGLERLVSKFQNLVRTQVQPDEFVSLFFNVANQLEDDRRNFALNRLREMESLKQSPTDTITQYAYNLMSHQTKLAQRCLDDRTSRRHSSAAICKYGTSTQECSCLFSKVFRLPCRHILMLTTELKVKTHIPFEPRWTVQYCLFGCDTSTNATATTGSSGTFLEQVVVEEGHRQAIQPQQIHAVGGVRQQQYVLATPGQPATPVSQVIFCGGGVGSVSGVGGAAPVITSVLPAGGAVLTPHHTLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDU3</accession>
    <name>A0A0N1IDU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDU3"/>
    <dbReference type="STRING" id="76193.A0A0N1IDU3"/>
    <dbReference type="InParanoid" id="A0A0N1IDU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF48">
        <property type="entry name" value="GH09711P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19981" checksum="DD6DB3991481F3DA" modified="2015-12-09" version="1">MFGGPKLVVWFHVNILSQRSSWASCKLRVFALANRHHELELEERNMANLLAKFRIDYSSLTMVQDITEPPQPETKQLFDDIIKSFVGDNAREECRISESELSTLAEKTNRQLRLRELLLANSQEARLVVMSLPMPRKGSISAPLYMAWLEVMSRGLPPMLFVRGNHTSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEG0</accession>
    <name>A0A0N1IEG0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 99</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_04578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KPJ10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="pmac:106715575"/>
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    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 45-like"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="Znf_AD"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="6"/>
            <end position="80"/>
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        </location>
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        <location>
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        </location>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="56"/>
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        <ligand>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="531" mass="61921" checksum="4BFF8534FD4FB7F2" modified="2015-12-09" version="1">MTKVDKYCRLCAELTEDLIYADEEAAFNSKIAKKMLWINIDVSPSNKLPKSICYSCFDQLERTWIFLKNVREAQEKLNQLFSTNSEHKVKLGKQSSDVANPVDMNWDDFQDVKVDIKDEDIMTVITTNKFIEGLENLKTEQCPENDQDFVIEDNGFSSSTDSEQPSDVTVKKKRSKKKVSQHDKHEDKTLYIEPIDIADLDVTWEEEACRCAHCDAQCKNISLLRLHSQHIHNSCCIFKCVSCGKVVSNYKSFVKHLRLHKEKLNYCCEYCDQKFTMTKFIKRHKHVEHGSGNLTCCRKCGMIFDTVEQLHDHLEKYNKSIKKMFRKAIDNVEEQDLKCNHCHKEFKKRTHLNQHKLVHTDRSRDFSCHICGKMFFMKGTLSTHIMTHENVKPFKCEFCPMAFKAKGNLQSHITLHSGTKPFVCEQCGKSFRVKRHLKSHSIIHTDLMPYKCQYCDKTFRFKTRLNLHLRQHTGAKPYNCAQCQRDFTNGSNYKKHMKRRHNIDTSSIWKKYLSNGSAATEEGKDMDAGKT</sequence>
</entry>
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    <accession>A0A0N1IFG2</accession>
    <name>A0A0N1IFG2_PAPMA</name>
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        <name type="scientific">Papilio machaon</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Lepidoptera</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
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        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ16139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="404" mass="43612" checksum="D4565F0F2AF9EBCB" modified="2015-12-09" version="1">MTLCFSNIKTARNIARGAAHTNLRVARDAFAKAAALRLLEAARTGDVETARALLDSRPRLVNCRDVDGRHSTPLHFAAGYNRLPLAQLLLQRGADVHAKDKGGLVPLHNACSYGHYEVTELLVSAGAGVNAADLWRFTPLHEAAAKGKADIVRLLLKHGADPTRRNRDGLTPLQLVRAGDCDTADALRGDAALLDAAKRGDLARAKKLITAQNVNCRDAHGRNSTPLHLAAGYNNLEVAEALLEAGAAVSARDKGGLVPLHNAASYGHLELAALLLRAGTPPNAADRWGFTPLHEAAHKARTQLCALLVSCHAHMHTHHAHMHTHHAHMPTHHTHMHTDHAHKSTKPCPQVHKPHPHDEIKAKSDTEALVIGVQYDIVTIGNPAYPEYLITYQIVNEEISTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFN1</accession>
    <name>A0A0N1IFN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter A family member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFN1"/>
    <dbReference type="InParanoid" id="A0A0N1IFN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="795"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1289" mass="142444" checksum="D619B135D21DB73D" modified="2015-12-09" version="1">MNEQCTFTTERAGLLWATRVLRHRTLELLDKEAIRIVGLQKSFRHCRKPEIKAIDGIDLSIYEGQITAVLGHNGAGKSTLFNILTGLTAPTAGTAYVYGLDVRCVVGIPSKRLSEEVHKAMSEVGLLEQAEVFSKHLSGGQKRKLSIAIAFIGDPKIIILDEPTAGVDPVSRRQTWRILQRARRGRVLLLTTHFMDEADILGDRKAVISKGRVRCAGTSLFLKNKFGIGYHLTLVLDGACREHQITRLVRGHVPRAEKARRHGRELSYILPHYAVHLFPPLFQAIEHEIKEKTNRLGITSYGVSMTTLEEVFLSLEGENAEETEAVEGVSSVKLVRARALSRSLSLQSKTLSYQELNDKEQQKTTSLPTPPHTASHALHSTTHGVEHVKVPVETPASALGEPVKTSPSCWRTFCALVYIRTVRMIRDPYKLYVMIFMPISENFGAFSLRDSIIPYGKIMTYFNSTYTHSLPIIINLLDNSIYRVLMSASNQLSSFKPIEVLTHPFQQTEQQEEFNLGNMVCAIFMGMIFGLVPVTLAVDIVYDREIKAKNQLRVNGLSMSMYFLTYFTILIFIMVITSVGVLVLVILNDIPSLTNGSAITMLSGLLLLYSPSAILFNTCLSYIFDKMDSAQSIMPNITTWIGVLPFVLVAVLDTFKWGSDIAFYLHLVFSFLDVMYIPYAIIYYVDRVYLTCNLRGLCMEPELWSYFTAEVWVLIVAMLVHVPICGAALLAADRLKSGGRICPKSSPAKRVLDTESEAGGEVGEDEDVRRERRRVAAMLQRTQQHAPANTPVPALIVHNLRKEYKLRGSSSRGLCDSEEPLRKAALARLSLAVHGGEVFGLLGHNGAGKTTTMKIITAEERLTCGTVMLGGKNIEEAQSSAFQMLGYCPQHDALWKNVTIREHIECYAAIRGKSSPAKRVLDTESEAGGEVGEDEDVRRERRRVAAMLQRTQQHAPAHTPVPALIVHNLRKEYKLRGSSSRGLCDSEEPLRKAALARLSLAVHGGEVFGLLGHNGAGKTTTMKIITAEERLTCGTIMEHASKNAEDCSGGTRRKLSFALAMVGDPRVVLLDEPSTGMDPRSKRFLWDTILASFQGKKGAILTTHSMEEADALCSRVGIMVKGSLRCIGSTQHLKNLYGAGYTLEMKIGQNNQKVMLDSDLSMTSSPLRSDENSPSLGEADEGGSGGGSVTAEADAEAEVEAEAVDISIHTPLVAGTPPLPRQQHHSNKQLLCRALHPLTLSSLARCFQPIESAKEKLNIVEYSFSQTTLEQVFLKFAQTENVESSEQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGJ0</accession>
    <name>A0A0N1IGJ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neutral ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGJ0"/>
    <dbReference type="STRING" id="76193.A0A0N1IGJ0"/>
    <dbReference type="InParanoid" id="A0A0N1IGJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="16400" checksum="CCC550E2CED8F78F" modified="2015-12-09" version="1">MPGPIPSYKVHRTHFQVKIEKCYHEIRLPQLAKVKQLLVPEVDLGLRQQVSTFFDPDYHKFVAVQFDTQARFPYEWQPHVVSCSVARVGGLVMAAVPGEFTTMSGRRLRRQLARAADNIAQRVVLAGLSNVYADYIATPEEYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHB3</accession>
    <name>A0A0N1IHB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Metastasis-associated protein MTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHB3"/>
    <dbReference type="FunCoup" id="A0A0N1IHB3">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IHB3"/>
    <dbReference type="InParanoid" id="A0A0N1IHB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035170">
        <property type="entry name" value="MTA1_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF29">
        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17226">
        <property type="entry name" value="MTA_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="13">
        <location>
            <begin position="84"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="724" mass="79041" checksum="43885F2AE02B00DB" modified="2015-12-09" version="1">MEEESTELPGTDGLAPKQRHQAKHRELFLSRHVETLPATHIRGKCTVTLLNETESLLSYLNKDDAFFYCLVFDPSQKTLLADKGEIRVGSRYQTEVTNLLKEEPRNSEDLETLVWTPEHGLTDRQIDQFLVVSRSVGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMDTLHKSGYSIEGALSSLVPASGPVLCRDEMEEWSASEANLFEEALDKYGKDFTDIRQDFLPWKTLKNLVEYYYMWKTTDRYVQQKRVKAVEAESKLKQVYIPNYNKPNPALVSSGGGAGAGGAAAAAGKAGAVLNGGTNGTAAPNLCASCQVTNSNQWYSWGPQHLQYRLCGSCWQYWKKYGGLKTAGVFGESEAEAAKGAREGDETALSASHRPHRCTVLNCAKEFKLRAHLARHVATAHGAGEGARPVMKTRAAFYLRASPFTRLARRLARALRRPRHYARSPFSPINLHQVKHECTLAMAGGVGAGIGAEVRGAARARGPVGAVAARLAAAHGGAAPRAQDWLTLTPRDRMPAPNHVAFPKPPKAPDGSLMYERVASRAELEARRSEPVPAPAPAPAPPLKRRAYDDINGLDRAGVGVGGGREVPAPPPAKRPNKHPAPMQRPSREQYAAMCARAQATGQPLPAHVFTHVNGKPTNLTGRGGRRHVISWMDAPDDLYFRATDLAKAGRRTLSSGEPRDPRAHPPRPLRPPRAPNEDCIFGNRIAENGFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II24</accession>
    <name>A0A0N1II24_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_03148</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Myofibril</location>
            <location evidence="13">Sarcomere</location>
            <location evidence="13">M line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the hemolin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460393">
        <property type="protein sequence ID" value="KPJ15358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1II24">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1II24"/>
    <dbReference type="InParanoid" id="A0A0N1II24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13325">
        <property type="entry name" value="PH_unc89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000344">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000519">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000796">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000802">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000873">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000940">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001036">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000145">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000919">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001381">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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    <sequence length="4819" mass="542987" checksum="F5AFEEF8F077461B" modified="2015-12-09" version="1">[encoded data, 4819 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II76</accession>
    <name>A0A0N1II76_PAPMA</name>
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        <recommendedName>
            <fullName evidence="1">DUF4746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="DUF4746"/>
    </dbReference>
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        <property type="entry name" value="DUF4746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="10001" checksum="A8F8761CC7E18707" modified="2015-12-09" version="1">MVSRKRSNALLTLAGLNPCYISSDLESGERDCLAMFPVGYGDEYVEEESVVEEEQVVVRITVTTLLLFKRLSIGLDSKVCCVGPFFILHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0N1II96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050784">
        <property type="protein sequence ID" value="KPJ21495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II96"/>
    <dbReference type="STRING" id="76193.A0A0N1II96"/>
    <dbReference type="InParanoid" id="A0A0N1II96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8532" checksum="36510696FB51DE6A" modified="2015-12-09" version="1">MFENVDSVSVREARDTLQLSGEAWARHVRPLLDAGLIAARGNVPSLTRPRPYTRGRSLAPQGRPRGRRTTLMQNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIP2</accession>
    <name>A0A0N1IIP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIP2"/>
    <dbReference type="InParanoid" id="A0A0N1IIP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873986" evidence="2">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="26059" checksum="2750FFB723F07DE3" modified="2015-12-09" version="1">MVEAVLVCQLVLGALSSWASAQYPFPMAALGPAGGGPAGPGGLPLPPHGAHLPMPMPLPMHMPVRQPQMPVVVMPYRSKASDRTFNQKKRRRPHYSTEESSSDSTSYEDSSSSAEFDFRRARGRRQRHKKKREVLTPVISYVTRSGRVVYQKKVKKENPAEWLGLGAGVERECLGRAGACPGGAWACPGGAGSVSGRGEAGACPGNAHRASLAVSFSMSSCSGASSLLSIRLNSCQHDKVTHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJE0</accession>
    <name>A0A0N1IJE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein Mlh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJE0"/>
    <dbReference type="FunCoup" id="A0A0N1IJE0">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IJE0"/>
    <dbReference type="InParanoid" id="A0A0N1IJE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="155"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="553" mass="62908" checksum="896AA6730E8CA436" modified="2015-12-09" version="1">MAEPGIIRKLDENVVNRIAAGEIVQRPANALKELIENSLDANATNIIITVKAGGLKYLQIQDNGTGIRHDNLDIVCERFTTSKLQQYEDLQEISTYGFRGEALASISYISHLTILTKTAADKCAYKASYENGKLKGPIKACAGNNGTQITVEDLFYNVLARKKSLRSATEEYSHIMEVVGGYAIHNSHVGFTLKKFGENTDIKTSIKSTVVENIRILKLFFLKLDPRNVDVNVHPTKHEVQFLYEEQIIDKIKSCIEAKLLSCNSSRVMYTQARLPGATMVDEIIKKTTDGAKIYAKDLVRVSSDTQKIDKFFQIASKRNENETNNAKETEKIVSEEIKDKPIVQINDEASDILENSLIEEPKEIKGKEKWNLHTAVEQANITYIDPKESFKTRTFKYERVETKLTSVKQLREMCEVAKQMTLLLLSKKEMLFEYFSLEMNADGELLALPLLLDGHTPFMGALPTYLVRLVTEVNWDSEKECFDTFCRQTAIFYSQPNPDSIQETQKSEEWKQEHVIFPAIRRNFLPPNRFVTNGVILQIANLSDLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJN5</accession>
    <name>A0A0N1IJN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJN5"/>
    <dbReference type="InParanoid" id="A0A0N1IJN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="82" mass="8922" checksum="4F8FCA8D8BC089C9" modified="2015-12-09" version="1">MNPHCTRKVIGGELQERLIPVPYSKTSTDQADQLASVQSVGCCFVSQRASVAARRSECSHRARSQTDESGPTPTGLGRHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INR6</accession>
    <name>A0A0N1INR6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461053">
        <property type="protein sequence ID" value="KPJ09933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INR6"/>
    <dbReference type="FunCoup" id="A0A0N1INR6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INR6"/>
    <dbReference type="KEGG" id="pmac:106716331"/>
    <dbReference type="InParanoid" id="A0A0N1INR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114966" checksum="1E6E5EF4D067023E" modified="2015-12-09" version="1">MDESLTDFQERKKICTGPKTNKPRVKKLISKKRLKGQKDIRTLVRPKKNELLTFTKDFNNVCAQGGIDVDSQQLQLAIALSKSLQQSDQTETEDFPTNNLTSQERTNRIRRTLQEYGFRIPQAKIKLEACKRIKKYRKPYKLLQITEEERLQKICNRYSQVLFDNPDKSFEKDTNDCNIDSKLYHLASNTSYDFIRTNKIYITEILHEISVSKGNLLRDWSDIPGRPESPKLVEDYVISMQDIECSQNELDIILSGPLYAAKDILKSKLNNSYLNTINQISNIPEINITSENTESKNNEGLNELQSSQDNLLTMQHKQNRSNSPDIFDDDTSIIDHSISDNQNVEKESTKIRDSNVSILNLTSTEVTNKVDACSQSSDNITKRKSNDFMDLTECVPVKSHCKIKLLETTNKVDLAHNSMEFTKCVNPISQDSNNSKEQTKNSLSTEECVSLEEEDKTRDGIPAVVSELEKELDYSSDNTIILKDDYIDLTQNCGPKVLVEDSLRDDNMETMDLTQSSNSNDDLPVVNIPGTQRLSPDDTIIVQYDGCDDIPQTNIVAPSNSIKLNNDVIEVNEDFLDISNILTVRSPSRTENRSTIIHNSKYRTEDLAESQSFSSEIVTSSNKENGVNIDLTQSSDSTVDGYHESSTGNVSENLQINDCDSLGKKGDVSIDYDELDHVVENVSPIDEERKHIQSRATNFSQSPNNSSISDNFELCDRELNYSLYKSRVDIDYEGISIVDTNNEVNYINKSKSTTCYNNYTINRSLSESDLPISDRTNCKDKQYNITLNKSACSTPIKATVTNDRVSIKTPTNSEYVVKLGEVTPMLDYEAMSSPEMNKELEKYGLKPFKRKRAIQLLTHLYNQTHPIIEQCSEDPVPFKKFKPNSPEINSSEKNNIILDKENIYSETKTNPDIRNIECCSDDWVFQKRGKAKVYSCPVPLHIAFHNYVSCRRHLREAILRYEPINIDVIHKDLVSYGYKYNPKDLLKFLDRKCITVKTADNTRNNKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP57</accession>
    <name>A0A0N1IP57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDB1-and CUL4-associated factor-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460735">
        <property type="protein sequence ID" value="KPJ12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP57"/>
    <dbReference type="STRING" id="76193.A0A0N1IP57"/>
    <dbReference type="InParanoid" id="A0A0N1IP57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="17728" checksum="574E00EC04114A67" modified="2015-12-09" version="1" fragment="single">DGLRKLYNVISTLPILGSDEEESRVSEDETCAARQIVRHVCVALRRYLEAHLRLRAAQVARQQGDNVPEPPPYKASKSSPEEIQEQIELLQSVAWSRWPPVDELLELGGVALLLQVVGYAYEWNFNGRDCICSITLLTSLVCIRGHVNCDGVRESLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPF7</accession>
    <name>A0A0N1IPF7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPF7"/>
    <dbReference type="InParanoid" id="A0A0N1IPF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17809" checksum="426A49C39450361D" modified="2015-12-09" version="1">MDFGDKRKKQKPYSEYERQTLMQLVQQKIDIIENRRTDVITQKRKNDAWEDIRNKFNNSDNVSHKASVAQLKKMWQNLKSRARDAKAALAQKKLTDCGPAHPDIEVEETQLTDILTVKENIVMHISEKKFNDMCEVNPHLASVVDYGLVTPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPS0</accession>
    <name>A0A0N1IPS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPS0"/>
    <dbReference type="STRING" id="76193.A0A0N1IPS0"/>
    <dbReference type="InParanoid" id="A0A0N1IPS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="24583" checksum="BFF5FC3011BD732F" modified="2015-12-09" version="1">MEEQRFREQSGVSALLQQQLAPMAALAHEQQQQFLQGEFQQLPSPLYGVQHAHHHHHHQSAPMPDGSPYYQPNAGVGGGVGGGMEGGMEVSALGLARGYASPGGAGATGGAYSSPRAVYASPRSQGYSPGPQRLAPTPQPQFPSSPAAFSGPSPPRAPYGSPAGAGGAPGRGFAARSPLYAGSPAPYRQQPSPAPQQRYSQSPHAHSYSRSPAPAAAPAPQVTELRTHYITTAEFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ66</accession>
    <name>A0A0N1IQ66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ66"/>
    <dbReference type="InParanoid" id="A0A0N1IQ66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="264" mass="28269" checksum="F5CF8E8B5DB0275E" modified="2015-12-09" version="1">MDCSSAVVQVREIYLEEGSREAVPEFSLHSLWTQIAPLFQPPLLWRTLLLYYLTFVIYIANNSFAIILPTILNVFFTSYASSSAGAGFCDLFRMAGDDNTTVLAGHDRITIAKEGSKCSGSIEDNTIWAGCAHGLSFFLLNALISQCAGRRKVLSISILLVAAAAAFVIDNTGEAISGLIFFYIFLTTAMVFGVVSSYFVDLYPTSYRGMVACLGMMVARLSAFAGTNLISSNMTEHCSVAIYSIAGLVISGAVAAALLPVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFG0</accession>
    <name>A0A0N1PFG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFG0"/>
    <dbReference type="FunCoup" id="A0A0N1PFG0">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFG0"/>
    <dbReference type="KEGG" id="pmac:106715537"/>
    <dbReference type="InParanoid" id="A0A0N1PFG0"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9695" checksum="E108469BE718684C" modified="2015-12-09" version="1">MTIFHDEIEIEDFDYDEEEEMYYYPCPCGDRFQISKEELMAGEEVATCPSCSLVVKVIYDLEKFKAEAEEVHNEEADKEVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGA5</accession>
    <name>A0A0N1PGA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-associated antigen 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGA5"/>
    <dbReference type="STRING" id="76193.A0A0N1PGA5"/>
    <dbReference type="InParanoid" id="A0A0N1PGA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="575" mass="61794" checksum="39D3F77FFB0D494C" modified="2015-12-09" version="1">MLARGRYRYSYVSELCQVGRQPAGCEGGGWGYLCAPVCVMTCACAAGRNTAFTAVEQPAPAPRHYPVPRLACCLFDTYQKARLTFAQAVADLATRSTNVKCLDSAGALELLRPLVSDANSTVRQCAVVAAARLAEHDEAVARQMLDGGILTTTLENLHKFNVYYKRSALYLIRAIAKHNEELASMIVRFGTLEHIVACMEDFDTQVKENAAWALGYIGKHNELLAGKVVDAGTLPLLVLAFQEPEISLKQITAGALVDLAKHKPEAVVDAGSICHLVRGLDNQDPKLKRSTLCALSAVASARVELAEAAVAGGALPPALLHAAHHAAPVRRAAACLLRDIVRHSIDLAQLVVNTGGCGPLVELLSENGGGARVPACMALGFIAGQSDQLAMAVIEAKAIPALVEILQNNEAEEAEVCAASWTLGHIAKHSPQHSLAVAVANAFPRLLQLYTNPKSSGEVRARALCCLKQALQCCLHRPALEPLLHAAPACVLKYVLAQYAKILPNDARARRLFVSTGALKRIQEIDTVPGTSLKEYINIINSCFPEEIVRYYSPGYSETLLDRVEAYTPQVIFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGG7</accession>
    <name>A0A0N1PGG7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460423">
        <property type="protein sequence ID" value="KPJ14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGG7"/>
    <dbReference type="STRING" id="76193.A0A0N1PGG7"/>
    <dbReference type="InParanoid" id="A0A0N1PGG7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="19890" checksum="23DA17ED47BD109D" modified="2015-12-09" version="1">MLHISEKKFKDTCEVNSHWASVVDGLVTPNIGALSPVLSVTCVTGDSAFSYLQSYVTTIERREIMFTKPKSYEFGYSVKDSRSGNDYGRREKSDGHEVRGEYRVFLPDGRTQIVTYHADWKTGFHADVRYEGEATYPNNVQGGYNYNAPTDFSGSLTGFHGNDLSKQTVYDQNSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHI0</accession>
    <name>A0A0N1PHI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460047">
        <property type="protein sequence ID" value="KPJ17999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHI0"/>
    <dbReference type="InParanoid" id="A0A0N1PHI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="28260" checksum="5E3E188BEFA156B5" modified="2015-12-09" version="1">MADRDFDLLVNTDLFLTIFKEDYEALAEVAEDNDDWEKYVKSAIENFYLEFNKIYYNLEHVQSKNSSEDNYNKAYDLATFLFASRKNFNAVKMAAPVRRIADLIKSIIGGPIEMIQTSCKRDMPVWQCNIAYVSKLIAAEESCPNIWYHSLVLETMLEYNRVQTLSIGDPITKTLGHVKSKNKSPKNLTQAYKAFEFILKTLSETKESARYSLQLRAKLYQFITDLQNDDNLDCNNISTPLYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PID2</accession>
    <name>A0A0N1PID2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460419">
        <property type="protein sequence ID" value="KPJ14866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PID2"/>
    <dbReference type="InParanoid" id="A0A0N1PID2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="43716" checksum="1CDEB0C095858573" modified="2015-12-09" version="1">MRKKYPNAPVVHPPSRTEFNVTAKSAYVVDNGEEQTRNNYIDDFLDGNLGIKKAIGEDEVIKNEMFKTNPLKDRYKMVFKYKRLPKVEMRYNLREQVKNVKTDKQKHENYDMSNQRWPKGKHWIHSRQLIEGIPPFKIDDNRSKKYYMFTENDPTKYTSPKYFKRDASKFTNEEAINVETLYLYQTDTDSPNMSVESVIDNLIESSFEGLNNLVSMEDNNTLNQSVNEKTSTVSNMYRAKNAIVQNGTFVNTTEFKDSLKFYFTTTASTLEETTIQNENVDDPNIILQSKANFLDVIAKMSNKIEQQNNASIEIINRMTGHNNLKHFTPRLRYFEEKHNNISNVSKDIEKSTEIPSIKRDIIIIAFNTSLDEKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIV0</accession>
    <name>A0A0N1PIV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eye-specific diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIV0"/>
    <dbReference type="STRING" id="76193.A0A0N1PIV0"/>
    <dbReference type="InParanoid" id="A0A0N1PIV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="334" mass="36386" checksum="C179A59097BB4367" modified="2015-12-09" version="1">MHRLRTTFKRSRTPTPADMKTQSSLEVPKQVRSASFDEIQLEAARGPGGGGGLLAVPQPGARSRSFDSAGSDDSGTYLEVPRLWSRRRSGKGTPPPCVHCRHMETWLARRSEERVTPERPPASSSAEDDDDDDDSETDSPRVLLTPVPPPRTLLPAPPSPPPSPGAPSFELQPPSDEPPILPQRRKSISRQEAFFVEPTGSSLENVRASEQDANGSARDTFVHDIYLAVPELKRDRAASVDSCFSKVSGGSRAEELSSTGDSLTVPGNNLRSRSVDIVLPTAEQSRYKALALTSSQTPAPLQHQGPEEADVIILQPLDERSVNKEINKIILYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ96</accession>
    <name>A0A0N1PJ96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box protein Pax-2-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044508">
        <property type="protein sequence ID" value="KPJ21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ96"/>
    <dbReference type="STRING" id="76193.A0A0N1PJ96"/>
    <dbReference type="InParanoid" id="A0A0N1PJ96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="32"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="559" mass="60813" checksum="5FF48B211DFFF220" modified="2015-12-09" version="1">MCVVNPHLASVDYGLVTLNLGQTPSPSVGMYSHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRLTLVHTSFALNRPAAVTLVDVEWTPRHDTQTSVPPPVQARITYLENRKSTVNFKAIACSIQGRFSPHDTFPTRVRHEAVMRRRIVRNKAAEKAKHAHNQQQQQQQQQEQEISSAQGSVVSVITHAGNAPGTTAVLSPAAEHVPNTGSYSINGILGIEQVDGLHNGSNAGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSKWSLKDEYKLLSELGGAGGAGGYYGELFDAPYEHAAHPHYTPHSATNDSTGSNGGAGEPPSAAASPDAAALVVLQPPAPPYPPYAHYDGTTTLASEYAYAAPYSQYSPYGGPYSHTTGLLSKCKKKSHSVSRPLGPWGPSARRLFKETAKRLVYITGDRRHSSYLGQRISLAIQRGNAASIFGTLPKRTPFNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJH5</accession>
    <name>A0A0N1PJH5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barrier-to-autointegration factor-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Barrier-to-autointegration factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460456">
        <property type="protein sequence ID" value="KPJ14662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJH5"/>
    <dbReference type="FunCoup" id="A0A0N1PJH5">
        <property type="interactions" value="1513"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJH5"/>
    <dbReference type="KEGG" id="pmac:106711230"/>
    <dbReference type="KEGG" id="pmac:106714090"/>
    <dbReference type="InParanoid" id="A0A0N1PJH5"/>
    <dbReference type="OMA" id="SKQQGDC"/>
    <dbReference type="OrthoDB" id="9997163at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000002">
        <property type="entry name" value="Barrier to autointegration factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00079764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="10202" checksum="2845DFED6C87774E" modified="2015-12-09" version="1">MSSTSQKHRNFVAEPMGEKPVTDLAGVGEVLGKRLETAGFDKAYVVLGQFLVLKKDKELFQEWMKETCSANSKQSSDCYECLKDWCDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJH9</accession>
    <name>A0A0N1PJH9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T-cell acute lymphocytic leukemia protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJH9"/>
    <dbReference type="FunCoup" id="A0A0N1PJH9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJH9"/>
    <dbReference type="InParanoid" id="A0A0N1PJH9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19708">
        <property type="entry name" value="bHLH_TS_dHLH3B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000015">
        <property type="entry name" value="T-cell acute lymphocytic leukemia 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="38299" checksum="08E93DB68EFC7D0D" modified="2015-12-09" version="1">MVARVDVWVASSSDLLEFLRGIALYSTPRRGRGSDVGPSFGWEAYPLNPFVPPMHGGEAKGTLALSSAGRIEADNDADHNDDDGNPSAMASDQESSDEEPDSEMLSDDLYLQDSDDDRQTRSVQSLSEDLPPLNCLLRPPRKLFTNCRERWRQQNVSGAFAELRRLVPTHPPDKKLSKNEILRMAIRYIGLLCEVLEWQKSHGLLTNKENTDLAVKCESPLSPQSRHLRLKRPYFDDDKRPKIDGDFGKYGDENEENLRRNIHRSVGFNKDYYFGKDHVKILRTQYYFPSRWRQNVPFRNLAAERNGNNLLMIAPAQSKEDDSKSGRSKDKDGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK06</accession>
    <name>A0A0N1PK06_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Vesicle-trafficking protein SEC22b-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_04899</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK06"/>
    <dbReference type="FunCoup" id="A0A0N1PK06">
        <property type="interactions" value="2014"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PK06"/>
    <dbReference type="KEGG" id="pmac:106708173"/>
    <dbReference type="InParanoid" id="A0A0N1PK06"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000004">
        <property type="entry name" value="vesicle-trafficking protein SEC22b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="24957" checksum="C506721B49193322" modified="2015-12-09" version="1">MVLMTMIARVVDGLPLAATMQEDEQSGCNVLEYQNQAKMLFRKLGPQSPIRCSIETGPYLFHYLIENEICYLVLCERNYSKRLAFSYLEEIAQEFYHQYGKRVNTVTRPYTFIEFDTWMQRTRKQYAEGGARARRSGATAQLGGQLGDVQRIMMQNIDDVLQRGAVLSELDTKTQNLSMMSQKYKKDATYLNTKSMLVKVTAGAVILLVIVLYFWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKS2</accession>
    <name>A0A194QKS2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoate amidinohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKS2"/>
    <dbReference type="STRING" id="76193.A0A194QKS2"/>
    <dbReference type="InParanoid" id="A0A194QKS2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ05994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="371" mass="41808" checksum="D355C3A81B6C6FA6" modified="2016-10-05" version="1">MFERIKPAFVELSELASTGAGGKVVFSTDDFFATCENMISDSEPVFIEDKYTEFGKWMDGWETRRKRVAGHDWCILKLATKCIIKGFLVDTAFFTGNYAPKYSIQAACLTPEEESHLPRRVEAIGTASSEDDLEQIKKLESDKWEEIVPITALQPGYEETRHNYQKVLSDEAWTHIRVNMFPDGGIARLRVFGEPRPERPALTDIVDLVSVVNGGCCVGFSNAHFGHPKNIIKPGKGRAMSDGWETARRLDRPNIIEANADGTLKLQGNEWAVFKLGFPGTIKKICVDTTHFKGNFPDSVKFEGVYLDLCNWTESKEIPWQTILNSSKLSANKEHWYKVDSEIFTHLRVTIAPDGGLSRIKIFGLVENSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM41</accession>
    <name>A0A194QM41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM41"/>
    <dbReference type="InParanoid" id="A0A194QM41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="27411" checksum="FB44DD0A7479D951" modified="2016-10-05" version="1">MPMTHQYCGHTAGLSRSPGDSALDFTINRVQSPHNVNELHSLQTCTQLALWLAGTWHGANTRLHLFPAHTVRLRPRSFPLCTSSPRRRWGRGASRPGHALARAVSSAGQRWAAASGTSAGRAAAAVWGARARVLAQTAGQPALSHGRRGRHDGDYLTVRTAVMTPRALSRHNTHLSRYLIAMLRGLDLASRSDEALGKYVVQVKMNDLLEMQIAGAESDLLSTVRDKIEKDGTSTNIAYGIDDALIHKEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMI9</accession>
    <name>A0A194QMI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lebocin-1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMI9"/>
    <dbReference type="InParanoid" id="A0A194QMI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264483" evidence="2">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13685" checksum="39E7E11ECC537F32" modified="2016-10-05" version="1">MKVSLIVGIVAALLIAEASCQYPHIIYPTYRPPPQRPIIIRTARQAGNGEPLWLYKDDNIDRAPTSGDHPRLPPYIDPIKLDPHTRTARSYDSRSSRRAGGTHTSSGGSRDTGATHPGYNRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNJ5</accession>
    <name>A0A194QNJ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNJ5"/>
    <dbReference type="FunCoup" id="A0A194QNJ5">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNJ5"/>
    <dbReference type="KEGG" id="pmac:106719935"/>
    <dbReference type="InParanoid" id="A0A194QNJ5"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="20667" checksum="966E6862C51CC87D" modified="2016-10-05" version="1">MNQAQVTKLVSKLRINVAAEPRRLRSPKGPEGRLNKLRKTVTGLIKYERIELNYNRGDEARQYAERLISEAITHGDCHKPTMEIADYWLLEKELVHKLFKVLVPRYENCNTAYTRMYKAPRPQYSRNTEKAVLELRGNPYPPLVNKQHNNRHLIQNILLDAAKYDYRQAKYAEMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP48</accession>
    <name>A0A194QP48_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Circadian clock-controlled protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP48"/>
    <dbReference type="KEGG" id="pmac:106719690"/>
    <dbReference type="InParanoid" id="A0A194QP48"/>
    <dbReference type="OrthoDB" id="6838842at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264529" evidence="4">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="250" mass="28276" checksum="2022F3312C4042B1" modified="2016-10-05" version="1">MCEKHVFVSFFVVVAAFISSSTALLAPDFIHPCNSSESECLIKATQDAIPEFSKGIPYLGVPSLDPFIIDNLPIQLPGVKVTFLDGKVTGLRKCQVLNVEAYLEKNVFILEVRCNITIKGKYTAVGRLLLFPINGEGDSKIKIVNSVIKMNIKTKYFKDADGRDHFGIKSYRYTFDYGERIHYTISNLFKGNAELSNTVLRFLNENWRVVTEEFGQPVVDYAMNVTIETAKKFFDAVPYDELLYVPIPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ16</accession>
    <name>A0A194QQ16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase sina</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ16"/>
    <dbReference type="STRING" id="76193.A0A194QQ16"/>
    <dbReference type="InParanoid" id="A0A194QQ16"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="38419" checksum="31C705CC9A9ED514" modified="2016-10-05" version="1">MIPFCPQFHSVTDKRSQNNEFGENSVTIVTEKKIEDDASSSGENVEIEDKPLPIVDPTIDSSEEGHAAQCACPNCDEVLSRFSECSICLEPLQGCGPCVCPWCGGVWCARCSRRMSRCAWCRGSLRAPAAPCLALQRLINDLMLPCRNYRRGCTELLTTSTRAKHEEECKYDSMICPVTATCSSIAFEELSEHLQSQHNIIAVYSQKIKILIENFQTKLKKTACCRTKYKIILLYQKSAFIIKVCIYNFHVKVEVMRRKLGYIADVKSESKKSEYCALIEFQSKALCTKSAILIENEAYSKKAEVQWNDIIMKSDTDEAITIHVNIGKSNAETFKKVNQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ61</accession>
    <name>A0A194QQ61_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ61"/>
    <dbReference type="STRING" id="76193.A0A194QQ61"/>
    <dbReference type="InParanoid" id="A0A194QQ61"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="442" mass="51551" checksum="BBDA42A4DC57DF46" modified="2016-10-05" version="1">MTLIYTWSNDFLELAFEVQGSSLQFQLQNPRKYRWDRQRKIRETTLVEKKYADIKLLKERVINIAEHEALAREPIHGNLTMFAFDALAHSTDLNEKKLHQIQVLAWGVELLQTYYNIGDDIEDNAKTRSGKPCWHQLPGVGLMAINDADLIRSFIYEMVKNNIEEPIACTVQNYLNELQTYYNIGDDIEDNAKTRSGKPCWHQLPGVGLMAINDADLIRSFIYEMVKNNIEEPIAYTVQNYLNETYFALNIGQLMDISLTRSNDFDQFTMEYYNLLNYFKSAFYTVKLPILLALSICNLHSKEAYMHVDKVCSDLGILLQMQNDIMDYVDSKSASLKTSSDIQNRKCSWPAVAFLENCNISQRKEFESCYGQSEPEKVERVRRLYKEIDILKIYRQHEQKRYDSMMEQIKQLPVDSIPSKEFFVKILNVLQNYTEDISPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQR6</accession>
    <name>A0A194QQR6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEP domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QQR6">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQR6"/>
    <dbReference type="InParanoid" id="A0A194QQR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IML1 N-terminal double psi beta-barrel" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1518" mass="172935" checksum="C8C84987BCC498F7" modified="2016-10-05" version="1">MKFFKLIVHQSSFSPEDLIINLKDYPGLKEKDIVEIYHPENDYPRLLLQVPKVEAPSRAVKDTISVEQSIATTFQLRTFADVYVNIVNVADVALDSVEVTFKDQYMGRSEMWRLKNHLVSTCVYLNKKIEYCGGAIRCQVYEMWSQGDRVACGVITEDTKIVFRSSTSMVYLFIQMSSEMWDFDIHGDLYFEKAVNGFLADLFAKWKKNGSNHEVTIVLFSRTFYKAKSLEEFPQHMKECLQKDYRGRYYEDFYRVAVQNERYDDWSNVLLQLRRLFTDYQKIVLQYHERANMEIPTAINSTAAQGNFLEVLNMMFEKHYLDRCFDRTGQLSVVITPGVGVFEVDRELTNVTKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDSGVNSIDDYSMPHWINLSFYSTNKKVAYSNFIPRIKLPPRMSQEPLKKMYEDEVKGKLVKEDEYMHNSIFDYDAYDAQIFQLPPAHSTCVQRVHKRTKKTSVAGLEISRKSPPTSVLHHRKMSDPDIHHSLGDMLTGGNKFGGLESTSDTTDSPSSINRLSPRSSISSNKPVIRTGRALINPFDPSHVKVKLTSNRRRWTHIFPKGPKGVLIQQHHYQARPAGEPASRSEDDCYDNITKDTGSSIINNNHPVYQVDGNIMSSRKRMISASGALGVLGTSVLSASGMGTGVSGMNITTTTSTTNNASLALLWGATGEQEWTPALTTGVDWKSLTIPACLPITTDYFPDKRSLQNDYLVSDYNLLPDDVNADFAQNRAIYKKPLTTNEVFKELVSQRLAQGFQLIVGVNENDVIESHCPSTPAPPPSKVAPQYGKPANSAPTKRYLLSIGRIFHKLTLVGSTITVTRYRPRHPYPPFNIHYRYRFHAPYHDTYEVSWVSFTTEKLENYSWNYMDHYICTRGDTDFALEEVTSLKYWRFRTLLLPLTNPATKQILEDESTHCDIYPTPTRQDLDQLTDGFLKMTELYFNKVKRPIKQRMALPAGGAEAAPTRRRHSTSILTRNAQQGGVSSPFRERVGSTRLPDRPRLRMEAMAAAKTVLERTQSQTGETEDTYDDGVIEPKLKANASLSEIIERMRHPTLGVGFLQQTVSLPSHAFVSIYAIHWLQANMEGMTYEKATTIMERMLQEKMICHASGDTTKRFVVGYYMYHILPQRKEKELSDYVKPLGDLQSFENEWMEVEVLGPRSPLAATGPGARDIAGAGPGARDVTGLPAFLAPNIDPKYMSRAADTDLPLYKNTHLDIDVSNKSDRIEWGHARYQATFRPDQAYEMCIQWAVASGNIVAELILGWARKAQNCRLQMVPIPADPLALPFTLKSDPLRGPIYVPLNEEPLLRGKSALFEGFPEETWEERLFLFQEAIACRFGFTKCVESTMHKGVGDQLYVHVTGNMFVLIPTAAAAERRAHHKPPNRLLNANRYPVHTDVAASPHKGYISWHVNDKNKDEFDNSRRMGFLWSWNHMISKKWKWLQPATGDETFQMRMLRDFKHFCANHEQRLTQFWDHCWDLHEKASGIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRV7</accession>
    <name>A0A194QRV7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRV7"/>
    <dbReference type="FunCoup" id="A0A194QRV7">
        <property type="interactions" value="1609"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRV7"/>
    <dbReference type="InParanoid" id="A0A194QRV7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000017">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="44496" checksum="6838327A02D38133" modified="2016-10-05" version="1">MYQDIFPNTAASDILNLLNKSPQCVYAGFDPTADSLHVGNLLVIINLLHWQRGGHDVIALLGGATGHIGDPSGKSTDRIALSSNVIAENIACIKSNLETVFENHKKYIWSEDEGKLKPLRIVNNETWYKEINSIQFVSDIGRNFRMGTMLLKQSVKNRINSEVGGSDQMGNISAGHELISRMMKQDVYGLTLPLVTTEEGDKFGKSAGNALWLDGKKTSPYSLYQYFIRTKDSDVERLLKLFTFYSLGEIKDIMFKHKHHPEQRYPQTCLAEQLTTLVHGEEGLARARQATDAIYSKDVKSLVSLRASDLEQVFDSAPVTKLLLSPGITVLKLGMMANCFPTEGDAMRIIQAGGFYINHQRIKNFNEVITESAHILPNLISLLRVGKRNYYIVKWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS57</accession>
    <name>A0A194QS57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cancer-related nucleoside-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS57"/>
    <dbReference type="FunCoup" id="A0A194QS57">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS57"/>
    <dbReference type="InParanoid" id="A0A194QS57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="18656" checksum="E2149A234B78D891" modified="2016-10-05" version="1">MAHSDKKFFILTGDPGVGKTTLIKKISSILSVKGTKVAGFYTEEVRNNRVREGFDIISLEGKRGRLARDQSLLNEPAKYKVGKYGVLVQEFEQIALPCLTKVPDNQTCLIIDEIGKMEFFSNSFKLKIKEIFSPTSNNIVLATIPIRRGDAIIESIRNNSNQKYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS59</accession>
    <name>A0A194QS59_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS59"/>
    <dbReference type="KEGG" id="pmac:106718049"/>
    <dbReference type="InParanoid" id="A0A194QS59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="317" mass="34876" checksum="269B3416BBE98A85" modified="2016-10-05" version="1">MDIRNNRGTIAFPAFKEMLTTSIDVGGVLSGNRMAGVPLGRSLGDGELDVEGICAEPGMACQNCTHAVTCVPLPYGYLKVPLQVCSNGKTCNAHIGGCSEKAVPECQPATQKHRHSCEQVGIFPDAFDCRKFHLCSPAEGLPDGRPADHRAALCPRHYGYNPQFAQCSMRLSNGQCSEKPVPDCKSVGETGPLPKSPNHYYVCLLKRGSLHPQVFICPHGWYFWDGFCRPEPQETVPTDKKITTENSKLDNRFEAETTTVKPTTSKIEGFFSTEKAVTYAADTFLADRFDLSNYETIDDVVPQNDYANSFESGTDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS89</accession>
    <name>A0A194QS89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein spaetzle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS89"/>
    <dbReference type="STRING" id="76193.A0A194QS89"/>
    <dbReference type="InParanoid" id="A0A194QS89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264590" evidence="4">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="263"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="366" mass="42204" checksum="B8188C3DF71F012A" modified="2016-10-05" version="1">MYFVSLTVWISLVHLLPSEAVIFTLHVPRRTRAVGGDDINKIPGSQSFKPNIPKECEDIGICDDVPEYPQQYVTQLIDQINKINQTNFNTDIIELTERFGPEEENFEMCQSKEMLYSPLAARSVNGKKWYYIFNKTNQTNFNTDIIELTERFGPEEENFEMCQSKEMINLSATNHESMRRSRAVQRIDASSSGIVFPGQTSFKPKIPKDCETVGICDNIPEYPHGYVSQLIDRMSAVNLTKFNVDVIEPQIAQRIGPEEENLELCRSEESLYNPKAAKDTNEQWYYIINKVKDVQQTFRVDICHRQNVACKSVVHFAQGYEGMCKQKYILRSMVALDYNGEMIEKHFLVPSCCSCIYRVTELKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSJ8</accession>
    <name>A0A194QSJ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual oxidase maturation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSJ8"/>
    <dbReference type="FunCoup" id="A0A194QSJ8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSJ8"/>
    <dbReference type="InParanoid" id="A0A194QSJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF10">
        <property type="entry name" value="LD27791P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="47591" checksum="BAE373572099C412" modified="2016-10-05" version="1">MKGWFDAFREEGGPTLYAYHNRTAVAADVPALALLIAALTLYLAFLAVFPGIRKERFSTFTIVTLSLFVGTVILVCKHGSSWHVAGTRVARAAYRAFSAERLDCWLAIHVGLGHVNVTLNALSWGNTTTGDPGVDYNEQFRWEEAGAIQEWYRKGLVRGLPYPLLSVAEHFAAEHDGFEWGAKYRAAGYTTSTLLWTALALWLLMNLLLVVVPRYGAYAMTSVGVTLCAAAGGYWACLPHVPLVVRLDGSMLFFSLGWCCLCLVVGLVIATLDLVWPHRFSTVLEVDYDTPYDRHVLIVDSRQRARPQAQASLPSRILRRLSSKTRDSERQVSMSIVNESGERGRGLGRDNPAYQHERKPNSPWRYPLFRRQIDRVDSASSLGSSINGNSSGIKMSPLPGSPPTPSLPISPHRYRPQLPATERVKDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSS6</accession>
    <name>A0A194QSS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSS6"/>
    <dbReference type="KEGG" id="pmac:106717796"/>
    <dbReference type="InParanoid" id="A0A194QSS6"/>
    <dbReference type="OrthoDB" id="7483946at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="25133" checksum="4D73A1EF7ABEFF0C" modified="2016-10-05" version="1">MSTFPRAYLGGDRGIACLTVYKAQVGLCKHLFPQKRRVLPVVMLISNKFVYFFILCAISTSLSSPTAYVNEGRGIGSTLWGWITYPFTWWNSSSTENEIETTTSVFTHDNNIEIAKHNVTVWCNDQTCTTMKCDKDGCNNVTCNIYDTDMSGVCREYTIKPEEIPTNKPITQVTEEQKTTVVTTVETSSLPSITNAGVEERPLELEAVLSSTVPIDDEDKDEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSY3</accession>
    <name>A0A194QSY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSY3"/>
    <dbReference type="KEGG" id="pmac:106718176"/>
    <dbReference type="InParanoid" id="A0A194QSY3"/>
    <dbReference type="OrthoDB" id="7214977at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="541" mass="62524" checksum="873619DF6D1FE7B9" modified="2016-10-05" version="1">MSEMYQEQHPLLCDDFSDDDFNCQSYSPRANIRMRPLVYSGRAKSQMKGAVTVMTRWPEHMWSTLKYWWMGIAMFGIIVLIVYNSVVAFSMLSLTYTKIGEPRLPYKAFENTVKDDTKLNVYMHIFANKYEEINLNTILPYVEIMSKKYQTLKFHLLAVINYTYKESDGMNDQSRNDLALESLWQDESFDINRKVVQNNLFLTYVSLSKYTSNPIMPKLNKNLSQDFTEFLVRALSIWEKGGVAFNPVILTPKTPNTIYLEQIQNILNKYKLYDNKKSESIINLNNHQGLHTKKKVNNIRDIIEALEAGDKSYNTTQYNLLEEENRVNLVSDKSFVINENISDPPLLLQTVHEIPNKKMKPIQQNKASDRFKKEIGGHHQHQLQMESKINLNNDTRPSLLPLFLEFLFPKRDIFISDDIRMRREKQNDKSNGSKNELESVYQPSDENDIHVAIENGNKQQDLISNYHTENCEHDTNTHLTIDLKGNVIASNTPCHAFVATLLKNAADHSEGETVSEYIIAQLTIFCKGVLFSSCKGIDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTI3</accession>
    <name>A0A194QTI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTI3"/>
    <dbReference type="InParanoid" id="A0A194QTI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264611" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15668" checksum="355E39C646E5224D" modified="2016-10-05" version="1">MSCLFLIVVLAIHSQAYVTEPPSFAKRLDRLYEKIERFNLAQSEPMRMEDKLNAKLAKLNALTPMRLGDDDEELVSTMQLWGDMSEEQVRDVVRELQRMKEHPEDKVERMTDGEYGDSDWNDEVSGCCVSLYVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU62</accession>
    <name>A0A194QU62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU62"/>
    <dbReference type="InParanoid" id="A0A194QU62"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="39" mass="4097" checksum="A1409F3CCBC7BBF7" modified="2016-10-05" version="1">MSAAPVAPLAPLAPLAPIAPLPAPQRPQPCYDVYMHMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU79</accession>
    <name>A0A194QU79_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein xmas-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU79"/>
    <dbReference type="InParanoid" id="A0A194QU79"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="499"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1722" mass="197190" checksum="94E5AA6BD68886E8" modified="2016-10-05" version="1">MCVGPQSTGWGSLDPKAMTQGAMAGAAAALTHRRCARAHWSRRCELAGQSLLLGERSPAPPLPLGNCLNSRPLPPLAVSLALMRSVPSPQSDSFAILLQELRFALQMIIISRCRRASSNKVWLARAPPRRRRVAARSSGEKSAHQTSIGSALCTNVPDGLFDTPSAKKHFSKFGRVQKIKFLPKKQMCIVEYEQLSGAEQAVLNAGAFDGFMFDVTRTKTRIRHKKDEDPEWLPDPELEKELSAMRGGSTYRVPRQKAMEIDPVVRNVKIPSPRTSKMNVRKTIPIARPKHKINAPPSSIETPAVIIAATTTLSTSEAAAELHQLRSRVSQSADEQWRTLDARDSWGGAGSRVKVGGATIGTCPDMCPEKELLHRKAEHQVMTLETVADSDGQLESWRAVKQYSRSSADQEIPMCYELRPAHVLARTCAYLLNEIADTDRQVTLADWFHFMWDRFRGIRKDITQQALCCAESIRLVEMCARFHAHCAARLADLAHTQFDQKLNTDNLTKCLQTLKHMYADVGPELKPREAEFRGYIALLNLGDSNFWWEIKQLPEEIQKSDSITFAIQVFTALDNNNYIRFFRLVKEKANYLQACILLRYFNDVRARALARIVKAYAPRGGSKFPAEDIMNALAFESVDSMRSFIDHYGLRFSKIDTELTVILDRNQFIEDSDPYPLSRAAKLIETKRKSTVGEVIAGGPVPKHDYRNHVLYSSFNKDGTLKETALLAEDLGYNTINDTNKDITLLKAEIRKLACNSDGRNIYDAYDTRDSAKIVKEKRKNIVVEISQPKTIPNKIVPAVRNETVKKIFSFKPAILVAPSEVIKGFKINDTRNIFSFSKPQQVTETKNVFKISKSQEITENKSIFTFSKHAEVTASKHLFTFSKPQVVSDSEINKGKTLLQSYVFKKPIIVEYNKNLDLSSRDGNNLNGGFNSSDIFKGKSSRLNNSRSAKSDKPDIQSVTQNTDSKLSPGSLFKKAHTEADEIFASGKASKDIYEFEEEDYPIKTFNEEKTKTAKKKMEEETKREEEKKRKLEERKNEELKKKKAEEDKKAELKRKAEMEKTFKETVEKNSEALVDELIGIVTKETVQNLIEEEVQSLKDVIENSEKIIEELLNDLCKEICTSEVNAEFFWAKKLMKKWFYVWQKQCVKNIKRRSFLEDTPVWLTNFTPAEEARNLNRVMKISPLKSMKLYGFKRFKVSEPDEMSSLKPYNVLEIIRSTLLKRMKEINYPYDKCFFWKITLVVPGSEKWLYRRVNVESWILEVFGDKNKNNNSDGLINVTRQTWNNLMDFAISIGLANKKLLSKHREAIEGTNGFLFYAEEKEVDLLNAIEETMKCTYSYQSVPVAVIVPTWDEAAINNIKEKLDMLVNKNVISCFKIFLVQKVKLNESLDLCTKSALKWLAKNCPKSPPIEIDHLKSICQRYLGNEIWQRLRCETDSRMEIVKQDLNKLVNCYNVAVDKLTDVITNTDIFNYPSFPLEFDQYLDHSSPYPKPYEFISSNVKQNENVLAIKAFMKKLKLVQSVTEFKPVNAINMEQQIQIYCNQVECLENPQKVAYKVIATLPNEFYNTQIPSAEFKKIFQKYSLIDFLNIVVYEKINSLHNFDNLCAIYEKASLEEYRNVHWLYDIFSGMMKHKAVDYDEDIDHFIKAKRRKLDGNEIENYMLEDKDYEKFETSLEAANASITSLKNYKDEVDNLEKQLEDEKKKSDVLDNMLQMALFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUX7</accession>
    <name>A0A194QUX7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUX7"/>
    <dbReference type="STRING" id="76193.A0A194QUX7"/>
    <dbReference type="InParanoid" id="A0A194QUX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="831" mass="89967" checksum="A3441BCBA351B1C4" modified="2016-10-05" version="1">MSQGREDNQRKRKQTDSSESASVFSNLMGTISTFIQRPFTDWFRKRKEPDSSNNDTDQSSEEIVPPPKKKKCHAIGRYEPSHDDVISRKSSKPNVHLPNQSSAYPHLSSSAALHKRATRAMASIPSCSSTSPSTSYISRAMKVKTRENSPTLTFDKSLDSPPSRIASRLVDKSFKTSSSCTNYYKTRDLLLSSQANIMLVKNNSKRLKTSPENISTSATEPKKSGPEPNEVPGQSELPEQSELPEQSKIPGPSVPLEPREPEVNKEITQMSQTSNKNQQETNIEATKKESPSNMKEVSEQNKSDDPFTKLILASRDKWECSVCLVRNDRSLTKCGCCGGPAKGHSNLLPSEQTPTPKFNFGIKNTSTFLMKTTNNSPFIITGTPLQKSNSDKSPVPHQTPKNDGFLPMYLPSISKVSNLSVVNENSLQSANLRVPSPANPAPTLDPNPAPPADPFPVPTADPSPAPNPDPIPNPNPAPILNSNPTPILTPTTNPNPIQMLTPIPESNSAPTTNPNPIQMLTPIPESNSAPTTNPNPIRMLSPIPESNSAPTPNSNLASILSYTPFPRPVRLFDSTTEPNPASILDPTLSPTQVPAAHTFTAAPTAAPTPVPPLITSSSPASTTMSSIIGHSYLENTKFIFGTPNVNINSGIKLGLSSNIPMPNAFEMQMPTENQLNGRIGVFGAGNAPENQTHSAPLFSSAPHVNIFGSNTTPVNTLSEHVEPRQQTGFVFGMMPKATPKFEQPAPRPPAAGLVFSFGQPQPMQTQPQPMHAQPLGVQPMSMQSTGLQSMQSSVYNFAGSQSMPQFNMGSSPTTHTTTRKVKRAVRRNNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY6</accession>
    <name>A0A194QVY6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thyrotropin-releasing hormone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVY6"/>
    <dbReference type="FunCoup" id="A0A194QVY6">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVY6"/>
    <dbReference type="InParanoid" id="A0A194QVY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="118"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="468" mass="53013" checksum="5830296005009334" modified="2016-10-05" version="1">MEPVENGTSNITQVLSDLFGEVLLASESSDDNRSNMDVSQFLSILKQNKHSTKGSHDNLDFGTLIKLVDGWRNKLNLTKPLEPSACNYCEGSFRDVILAYNSIHGYVSLVVCLFGSLANALNVAVLTRRDLAAAPINRLLKWLAVADVLVMLEYVPFAVYRYLNTSCVRRDFLYDARLTLVILEIGIVAKALFVVHEPILPGQHEMPYKWAAYLLFHMHFAQIFHTASICLTLSLAVWRYVAIKYSDKNHILCTERRCSVAILSSFVLPPILCVPTFLVFDIHTALVIEPSGPMILYHVDADQEGMLYLINFWVHAVVIKLLPCCILTVISLWLIFEVYRANEHQKKIRVYDICPTNKTGKRQNRANKRANRTTKMLVAVLVLFLVTELPQGILGLLSGLLGRCFFKGCYDLFGELMDALALLNGAINFILYCSMSRQFRMTFRQLVWRVHLHKWPTPLASHSDGLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVZ9</accession>
    <name>A0A194QVZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVZ9"/>
    <dbReference type="STRING" id="76193.A0A194QVZ9"/>
    <dbReference type="InParanoid" id="A0A194QVZ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="92" mass="10636" checksum="07A07910A15342F7" modified="2016-10-05" version="1">MGMFRYALRALHSAITVEKFVPLWTASILPQYPREIYDLKWTDPDEDGLVKFLCGDKQFNEDRVRNGAKKLLKARSGTTQGRLDGFFKVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW13</accession>
    <name>A0A194QW13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iroquois-class homeodomain protein irx-1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW13"/>
    <dbReference type="STRING" id="76193.A0A194QW13"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF46">
        <property type="entry name" value="HOMEOBOX PROTEIN ARAUCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="29531" checksum="57093098B6D051A0" modified="2016-10-05" version="1">MLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTDEDDDTMLSDEEKEKDDQEDKIKPHKDEERKSDELLQGMHHQLLGYGIKEESKRGPSDCGVPIPASKPKIWSLADTAACKTPPPAAQPWPQHAYGPGPERAAPVDGSANGFALPATAASPAGGAYGRYGGFPSGQYGQHPCVHPAAFPDVQTDTPPQTPPNMKVPSVANPLGSGGSGYCFPRHQQSPQRDPYHNPHHANNHQPNQPHHNEGSAAFKPFYKSSHYSNGFVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYN7</accession>
    <name>A0A194QYN7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom carboxylesterase-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYN7"/>
    <dbReference type="KEGG" id="pmac:106715698"/>
    <dbReference type="InParanoid" id="A0A194QYN7"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264735" evidence="2">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="24"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="536" mass="59554" checksum="63462F68218B825C" modified="2016-10-05" version="1">MKFLWLLCALCVANYVDSANFRVDPLVLIEQGLVRGRKSKDNVYSAFLGIPYAQVDSSNPFGPAVPPAAFEEEIFDADDGTVKCPQSLTASARGSKREIGQLDCLYLNIYVPIAAGMFNPLPVLVWIHGGQYTSGSGGEYDAHDLVKQGIIVVTINYRLGPYGFMCLDDPSITGNQGLKDQYTALRWIRRNIGAFGGNPYNVTIGGQNAGATSVLLHLYSDNEKLFNKAIVESGTPQSEGMFVNGDLDAAIKLAAHLGLNTTSNAEALTFLTSSSPHIVTAAATDINLKLGPCKEKSFSSVENFVETDPFTLSNERKIRNTPVLIGHTSKEKKGSVEMHGNEYFKTDPFYEKLRDNFNLNEEQLAQAAGIVRRFYIGDKPISSDVTAELEDFESDFIHNHPTQRTITNLLNENAKPVYNYEFSYGFSGEDAPHSAEIAYLFPDSNANDEAAEEDRLISNRITTLWANFVKYGNPTPQTTDLIPVTWESVSEETRPYLVIDTDLRLEHRIFNSRMAFWDLFYSIYGKLNKLARECDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ37</accession>
    <name>A0A194QZ37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ37"/>
    <dbReference type="InParanoid" id="A0A194QZ37"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="589" mass="66969" checksum="DC7BDBBCA1AC354F" modified="2016-10-05" version="1">MSQLVPLRKVVVIWQVMSILHHSKPLNESKAGIQVENVNSYWSGTQECMHNYWNNEQVAPVQENPEEDKSKGSGQTEEYRPGQVFSLNAQELMELQPERKAPLASNQQLQQLQQLQQLQQLQQLQQLQQLQQLQQQQQLYSPQQEQKQNLQQSLQQNIQPFYYLDPQLAGQVSLQPSHTVIARPHYTSNGGEASVGAALSVSDSGSATAHPFDQELLALFNQARQEDDRSQIYTQQILPQALGQQYQQVERYVTKPTKKPTKLRPKIQVVPTQASTAPQQYLIETTNVQSQAPALQYRPIQSQRTGQTLRYIPLQAAQPAVSQPLYERPESQGLKIVPAPNLQNLSPQSQGNYVFVPKYQQPEPTQQTQYKFVDTQRQTIQSVRQEQPRIAVERPLAYLKRVPEPEKARTVKIYNQSGLEGLSGVPQGGQNEQYYLRPLYRQNEQRPRYDLSALALRSFEQARAVESTKSPLSTIYVHKNTSPKKAARPSVRIESQREQSASSEYAIEQGRALEYQRPQLPPPKNNKAYTPEEFQALVAAGYSVTPIPVGNVGEQPAQSRSSVEAIQIPQRRVYNKRNQYLPLRSDEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ70</accession>
    <name>A0A194QZ70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pseudouridine-5'-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ70"/>
    <dbReference type="STRING" id="76193.A0A194QZ70"/>
    <dbReference type="InParanoid" id="A0A194QZ70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="15993" checksum="075F54C1F712DD6C" modified="2016-10-05" version="1">MIFKNVTHVLFDLDGLLIDSERLYTEAFSNICAKYDKEFTWELKRSILGFQGHECAERIIKTLDLPLTGESFMEECKKEYEKCLVFEDAVNGVKAALAANMQVVVVPDPRIDTEDLKHATLCLKSLEDFQPELFGLPPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZY9</accession>
    <name>A0A194QZY9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZY9"/>
    <dbReference type="FunCoup" id="A0A194QZY9">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZY9"/>
    <dbReference type="InParanoid" id="A0A194QZY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134764" checksum="B1E51C7AFB3BFB01" modified="2016-10-05" version="1">MPKFFPNLESFSVLWEEQEAPEYDIDSEDERWLKQQRHPELTELKFEQMMDKLERSSGQTVVTLNEAKLLLERHDDLVIAVYDYWLNKRLNTQHPLILSVKTEHRPGQSSNNPYLAFRRRTEKMQTRKNRKNDESSYEKMLKLRRELARALTLLEMVSRRERTKRELVRLTALLAERRYAAGDFTAQLPEPARQYNTVPISTLSFRREAYAVQHYPPRAPPTPVDQPRQREKRPYKRRKHRHHAAGSTQGLRDSGVCTSSDEETSVSAPSGASPRADTFDDGPFAFRRKPGCYYEMPTSTLCGDPVDPDSPSKEGLFEHELDERHRFTLTSVTQPYTRCVGFARRRVGRGGRVLLDRIATPLDDLWPALPFAFPSSSEHRKLRDEEVELETKAHRTPKEMTRDYHTGGKYPWRHAFRRHLKRNSNLWTVDLKPDADVKTDADIKPDKVKQEPMDVDEPLPDSTLPQDVTSDISVSARTIESAVRENLQRVMRKRSWSGCSHDSYDSDESLQPVEKEFEQFINEVNKKWLHFRPKTPPPSPPHDSKIPDDQFPLTTDTPFSVELRLAEEPPSGVLDPFITSEFTLGDLFTEPLKPDVDRSGNGLEGEDLLGHNFTGLTEAQVESILSETDLKAIEDVELSKDDKKIAISDDLLDELVKDVDKDPFLLQGQSSDGRAGSGPRRKRAEERFGSSVVHISAGKEPIYADKPEPPAPRTPPPTETPKEVKAPAQPVPTSKIIVEEVNEVPHIKVERKKKEDTIEEIQLAPGVQLKTVQTKHSPLKKHIITSAAHRRSADVVVTSQDSNQPQIVTVAVSDSLKVRLASQAAAVSGAGGGAVVGLIQNGPFTALALPVSQRDVVTASVGSVGTTSNVVNMATVGSVGSVGTVGSVSSATATRRVGAPLVQLAPAALAHKPLQLHPPPAVVVAPHVHHVPSSKLKVLHAHPLTHTQRAQLLQNRSLAQLPTVVSLAALGDGKPILKAAPGSVTQYFEIKSGQLGKGPHLVNVVRQPQPGKATVARLDINEARKRQVVFDGALKGNMTAATRPHRVSVSLDGRQIVRAALPVRAPSVRHQIQLKNRTVQVAAPLARPTEPATSITIAAPAHTSIPSSVVANLLHKNVQLPKGGQKIAISGPGGLTGNVQAIAFSTAQLKARQARLIAQPRPPPVAEIVEATTAPAASSSGMASGLSGSLPGALSGEAPLEGGGEAEDAATNGAVRRRAGDTLPMEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0U7</accession>
    <name>A0A194R0U7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0U7"/>
    <dbReference type="InParanoid" id="A0A194R0U7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="28606" checksum="B60BDA6B70526ACF" modified="2016-10-05" version="1">MQSYNIGCGSGRSLRQQRSPQTSPVSESARRAEPRHARRPRSSPAAPTPTTPGTAPTSQNNSLTEELMRLMDAELGEGQSEGTGRGPPLPLPDAAALDWATLVHTATRAMLQICEEHQYPTMDNLESLDNPANEPLQDTWPEPPISETSISTVMSNSPSVSINASVVGGASAVGGVNAVGGVNAVGGVNAVGGATGAVTSADSAACGCGLAARVATLEADAATAQRQNNQLEEEVRRLRRHNARLREESARAVWQLRHFTQWLKRTVDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1H7</accession>
    <name>A0A194R1H7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1H7"/>
    <dbReference type="FunCoup" id="A0A194R1H7">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1H7"/>
    <dbReference type="InParanoid" id="A0A194R1H7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF22">
        <property type="entry name" value="GH21596P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="196" mass="22174" checksum="CAA0C2E7875B5B05" modified="2016-10-05" version="1">MMWSTLLNFCEGTESIFLGSCRSSVQKIPARNKDQEQEVLTWITQVLGEPLPNGAYEDILKDGVVLCKLINKLSPGSVKKIQERGTNFQLMENIQRFQAAIKKYGVPEEEIFQTADLFERRNIPQVTLCLYALGRITQKHPEWTGPQLGPKMADKNERTFTEEQLRAHNAELNLQMGYNKGASQAGLGSFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1I5</accession>
    <name>A0A194R1I5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11658.1"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ribosomal large subunit assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Translation proteins SH3-like domain"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="30647" checksum="E81B6BD3332C56E3" modified="2016-10-05" version="1">MAPPKPKEVAKAPAAPAGGVAKKPKFGVPRNYDLGNGVVRFSKTKMFHKKAKYKFIGKKNPKAEKPKKPTVVVKQIGGEKNGGTRTVLLRRRKSFYPTQDKITTRSHHKTFSKHVRRTRPNLTVGTVCILLAGRHAGKRVVLVGVLPSGLLLITGPFAFNSCPLRRIPQRYVIGTSTKVDLGDFKLPKHLNDDYFKKNKKSTKRSVKRKEGEDIFASKKEKYVPSEQRKADQKSVDEAVIKAIGLRADKKLLRGYLRSAFGLRSSQYPHRMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3E5</accession>
    <name>A0A194R3E5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3E5"/>
    <dbReference type="InParanoid" id="A0A194R3E5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF1">
        <property type="entry name" value="RE43931P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="371" mass="41273" checksum="653429FFCA680023" modified="2016-10-05" version="1">MNVGGLIREDGFGGGSCPLAVAITSRARIPQASATSTTSTSTTIIPQPSVVHTEMSRKVCLAAALLALFCYADAQRRLALPDPKSCANRVRHATYRDGRGVLHSYFMSWEHAPTRSLEVDWLDARNICRRHCMDTVSLETPQHEIVLTVESRPQYSLEYSSRLAGCVIIELRHASAKIFMEKVSPPYLRDAKFMENEFVKQKIARGNVRYIWTSGRKCNFAGCDRPDLQPPNVNGWFWSGSGAKIGPTTQRNTGDWSYTGGYGQPQPDNREAAQPPNVNGWFWSGSGAKIGPTTQRNTGDWSYTGGYGQPQPDNREAAQGNDESCLSILNNFYNDGIKWHDVACHHVKPFICEDSDELLNFVRSRNPGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6M1</accession>
    <name>A0A194R6M1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone acetyltransferase KAT2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6M1"/>
    <dbReference type="FunCoup" id="A0A194R6M1">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6M1"/>
    <dbReference type="KEGG" id="pmac:106712532"/>
    <dbReference type="InParanoid" id="A0A194R6M1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="484"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="601" mass="68183" checksum="3166EB5A38C0E919" modified="2016-10-05" version="1">MTSQMTNDIGDIGMTNTEADSSQAHAQEATSSATPDDATSSNATTPSGSEGASRQSNLQRIQQRKQQVYNWPHNKKLLKLAIYSACQTPECSCNGWKAPVAQQPAKANARTDQPLANFTDPCRNCNHILEKHVTHLQGLAVSEVNRLLGAVVDVENIFMSMHREDDHDTKRVYYFLFKLLRKCILTRTHPRIEGPLGQPPFERPSIAKAITNFVLYKFNSLAQREWQTMYDLAKMFLHCFNHWNFETPSVRKLQVSNQEDISAYQINYTRWLVFCHVPAFCDSLPHFETSLVFGRTLLRAVFKSVCRQLMDKCHSERDRMPPEKRVLVLTHFPRFLALLEEEIFSSNSPIWDPDYKQVPPNHLQAILDNKNSVRRTGEFERVTPSGESKDGFTTVTLSSGSIKQEGTKRSVSGAGEAGGKRRRLDDDDVSERTVAEIVATITDPNYMCGPDALFQMQAPRDEAAKLEEQRKMIEFHVIGNSLTGPVNKQTMLWLIGLHNVFSHQLPEMTKEYISQLVFDPKHKTLALIKEGRPIGGICFRTFHSQGFSEIVFCAVTSNEQVKGYGTHLMNHLKDYHIRNNILHFLTFADEFAIGMNNSICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7P9</accession>
    <name>A0A194R7P9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat family A protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7P9"/>
    <dbReference type="STRING" id="76193.A0A194R7P9"/>
    <dbReference type="KEGG" id="pmac:106712135"/>
    <dbReference type="InParanoid" id="A0A194R7P9"/>
    <dbReference type="OMA" id="PYTCNEL"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="250" mass="27327" checksum="10A7A471E1911EDD" modified="2016-10-05" version="1">MEESVAVKHEGKNIDIKQEKQDNLESFKYEFDSGSQDSSKSGSGGYQRWAPNLNGVRKSAFTPYKSAQCTALTNLQRGNTQARVLELPQPDSSFHAKAGRGEITREDVKLEQYVDITDEHGLTALHWAASYGQLNSCQDLVWSGANVNMRGPEGETALHLAAAGGHHEVVKFLLNEGADADIQDDSGSTALMYAAAADFPYTCNELLIRGADLTLTNDYDQDAYTLTITNNCKLAQTVIENFLIGCLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R801</accession>
    <name>A0A194R801_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="2"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R801"/>
    <dbReference type="STRING" id="76193.A0A194R801"/>
    <dbReference type="InParanoid" id="A0A194R801"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="38801" checksum="40D0261388D46D34" modified="2016-10-05" version="1">MTEDERYEAVRHCRYVDEVVRDAPWEYDEEFLEKHKIDFVAHDDIPYTTEDCEDTYAMIKAKDMFVATERTEGVSTSDIVARIVRDYDIYVRRNLARGYSAKELNVSFLNEKKFRLQNKMDELKDKGKKVMTNIGEKRVDILTKWEEKSRELIDAFLLLFGPDGRLSNIWHEGKGRLMQALSQPPSPRASPPPSENGDVHEHSGRRQQHQLHELASLSEIPQPHRRQASSGSHSPFRLMSDPILGFFPFPPFLISRGWKEEVDLTEKGMKRMGKYSLSVGSVSPPPAKSRRYETLWEPHADASSSDGVGESEEAAKRQLTDDGSDSDDDDYQDTSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8T2</accession>
    <name>A0A194R8T2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8T2"/>
    <dbReference type="InParanoid" id="A0A194R8T2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="37822" checksum="59CB71F6E2E887F4" modified="2016-10-05" version="1">MYGKPIDTENCYWDGAFNQEDIAALVDGWILTGRIGFFMVIWLNINLWCTVLRRDLKYRNLAAFTTVLALRRGYQYIFYILRYMEYDWVDDIHNCSTYGFIDTFLGVYEVESLTHICIERYVVAKYIANGWPIRRWHYFLYQCLCLFFSLLYSLAPFFGVGNYVKDFSCLTCTYNMVLPDTWERYAVLSIFLLRSAKPVLFMLIMRFWTQQMEAKYDDKNVPWVEVRFAHIVDSLTTTVLGCWLPITAIRAIVIIAINFLGMEVDMKEYVWAIQWAVWVEWFTPAVVTVSLMSVDHLLRSKMFGGDKTEDDIIKVFEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9G6</accession>
    <name>A0A194R9G6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neither inactivation nor afterpotential protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9G6"/>
    <dbReference type="STRING" id="76193.A0A194R9G6"/>
    <dbReference type="KEGG" id="pmac:106711386"/>
    <dbReference type="InParanoid" id="A0A194R9G6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF188">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="411"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="67200" checksum="FBA13FB2942E0B8F" modified="2016-10-05" version="1">MNIFSFILSFLVAVISYLVYTSYVNTYSSIVTKPDKRYDYIIVGAGTAGCVLAARLSEDPDVKVLLVEAGDHMGFFTKIPLTSTAAQQGPNDWSVRTTPQKYSSFGLWDQTQFLPRGKGLGGSGQINFLLHGFGLPEDYNRWSRKGFKGWTFKDLKPYFIKAFGTTMSEYDSTYCHETSLCNAAPMKLKLLSDDNELMMTFKRASSSLGGRGTVLRRPAATVSAGLRHSSWDGYLKPAMQRPNLHVLINTQAVSIRFDNVTATSLYILQNHRSLDNIFVDREIILCAGTIKLKINLVVENEHVGANLHDHMNMPLYVSVRKPVSITLAKVFTASTLWEYVWRRQGYLSFPPVSGVEYQNKSAVKVFALGSASERLLRDLSNYKHQVYRDTYPFHNDTRKEGFMFLTTCSQPRSRGRVTLRDASTSVPPLVDTNYLHQYHDVTCMIKAIRRAERLVSTKAFQEIGARIHWPRPERCRTLWRYSADDQAGLKPKRKRFKSTKQEKKPKESAKVKTKSPKVSPPDEYLECLLREVAVTGHHAAGTCAGGTVVDNHLRVKGVNGLRIMDASVLPTPLSLYPNSVLVGMAEKAADLIRNTPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA48</accession>
    <name>A0A194RA48_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Opsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_13450</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May play a role in photoperiodic photoreception.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA48"/>
    <dbReference type="FunCoup" id="A0A194RA48">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA48"/>
    <dbReference type="InParanoid" id="A0A194RA48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="73"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ14379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="41870" checksum="4D9B238585AC3D70" modified="2016-10-05" version="1">MAVNSLDPGAVSAPAWAEKMEAYGSNHTVIDQVLPEMMHLIDPHWYQFPPMNPLWHGLLGFVIAVLGFISLSGNGMVIYIFTTTKTLKTPSNLLVLNLAVSDFLMMTCMAPPLVVNSYHETWVFGPLACALYAATGSLFGTISIWTMTMIAFDRYNVIVKGIAAKPMTNNGALLRILAIWVSSLAWTLAPMFGWNRYVPEGNMTACGTDYLNKDWFSRSYIVAYSIFCYFTPLALIIYSYFFIIQAVAAHERAMREQAKKMNVASLRSSEAANTSAECKLAKVALMTISLWFMAWTPYLVINFTGIFETATISPLGTIWGSVFAKANAVYNPIVYGISHPKYRAALYQRFPTLACQPAADDNTSHASGKTAICEEKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA79</accession>
    <name>A0A194RA79_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA79"/>
    <dbReference type="FunCoup" id="A0A194RA79">
        <property type="interactions" value="1341"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA79"/>
    <dbReference type="InParanoid" id="A0A194RA79"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="320"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="681" mass="79338" checksum="85ECE6E984627B15" modified="2016-10-05" version="1">MIHDALFVLWDCSQGDVSSLTSNYRLSQFYMPMKEMQKFIVEYVQLQKVITEFKILLQLHLFIQENCKQVEKLVIGNKDYTLTFVYSYVEKFQGLFNTINKIIGTIKERRLSGCEILSLTHQNILNGNEMVHSAILRIFSCINNVFINQLCAWLLYGELKDPYEEFFIYRNKKDDLSETVLSTPSIPNTCNKTLVTTLQQTSLDCGYNINPGMIPYFMPLSLAQEILFIGKTVILFGFDPRKVKKSNITLNSTLMPLHKLDYDSRRFTIWEEKESEFHSKLQQLKEPEVFEVYNLRCVVREIKECVTKHLWTVAVEEAHLLHELRLMKDFYLLGRGELFLELLRLTAHMLDKPTTRTSTRVGKDKFRKAKEKARVKKCFNTVAQKVAYCRDEERSEYMNHAFQLAARAVFLSNSADIEKFSFELPYVKPIADATANSSLDDDSSVVADGWSTIILKYDFKWPLHLLFAPEVLARYNDMFRLLLRIKKTQHDLHALWKTYKQSRRFAVCQLHNKLMFLMDNLQHYLQADVLESNFSRLMDAVNKTNDFEKLKEAHATFLADILSQSFLTTTTSERSEGDSSGDGVDMITNPVFVNIMDLLKLCDSFCSMSEFASDREAEDYYIKGYSDRFNKLVKQLTQLLVCLRDRACGAYLARLLMRLDYNRWLSAEAELTRSLTHMLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAF5</accession>
    <name>A0A194RAF5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAF5"/>
    <dbReference type="STRING" id="76193.A0A194RAF5"/>
    <dbReference type="KEGG" id="pmac:106711455"/>
    <dbReference type="InParanoid" id="A0A194RAF5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="32921" checksum="7FE7F125822F8DFC" modified="2016-10-05" version="1">MCETQGRLDGKVAIVTGGSSGIGFEAAKNLAYRGARVIIASRNSTKLVKARNKIQSVTGNKNIEHRVLDLGSLKSVRNFTDFTIKTEERLDVLVNNAGALGLSDRLTEDGLNLTMQVNYFGTFLLTYLLLPLLKASAPSRIINSVAVAMYIGHLDFDHWNDVGRYTTVQVMANSKLAMDLFSAELSRRFKDSGVTANTFDPYITKDTDILNNMEGLSKNISQLFVDIVGQPKEDVGKQIVMLAADPDMANITGKHYKFCREWINHWLAYEEDFTQQLWDASKQVVNITADEDWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAJ7</accession>
    <name>A0A194RAJ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAJ7"/>
    <dbReference type="InParanoid" id="A0A194RAJ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="24860" checksum="37CB13B806175C0C" modified="2016-10-05" version="1">MNACNLDLISTWIAAASGDYVPWEQSIKCRNVLDNVYLPDKDKKLADDLEEFISKLKKNTNLKEKSRLGFRRLASKNFLNEDDLRHYEQLVIMKKYPFLDIKELEMKFSPSNKDRRDNENFHSRMNMVPEPSICEPGEDLINVEISNRGLSGFAIPTQLVKHISTTEKNLLSTPETPQLKSENTHKFSKKSTEKNILKKLKDDVNQFLDKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBH4</accession>
    <name>A0A194RBH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Prolactin regulatory element-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_06749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBH4"/>
    <dbReference type="FunCoup" id="A0A194RBH4">
        <property type="interactions" value="1761"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBH4"/>
    <dbReference type="InParanoid" id="A0A194RBH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="32920" checksum="E349D042653FA139" modified="2016-10-05" version="1">MSRNRCDGLLAKVDFPLYTLETLTNRHVLVAGGGGASNTGVANGFEIFEISHNGNKFVAEEVMRHETGPNVVMNCSIRNAQGRTYLCAGQESHCQLYRVNVRMVDVAEMRRGSFRAENGLVRRRRRTVSENDNISKADIGTVDKRMSFEIRPCDSVQTDFGDDPLQRVVRISHNGKLMATGGVDGKVRVWSFPQMQLLFQLEGHTKELDDLDFSPCDNQLVSIAKDGLALVWGVAGAAGAREPLRTLTCQPPNGTKYRFRRCRYRPRLGCHHSHSFRIVLYLHVMFLFGYIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC98</accession>
    <name>A0A194RC98_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">X-linked retinitis pigmentosa GTPase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC98"/>
    <dbReference type="STRING" id="76193.A0A194RC98"/>
    <dbReference type="KEGG" id="pmac:106710962"/>
    <dbReference type="InParanoid" id="A0A194RC98"/>
    <dbReference type="OrthoDB" id="10253607at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF9">
        <property type="entry name" value="X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="732" mass="80020" checksum="46D21634B531B921" modified="2016-10-05" version="1">MADDIPDTGAVFTFGKSRFADNEPSHFFIKNDPVVAISCGDEHSAVICQNGRVFVFGGNAWGQLGLGHREEATRPSCVKWLKPQRAMFVACGRAHTVFVTDTNAIYTVGCNEEGQLGAGDTEPRSVPHLVELESTPAPVRQVSAGSSHTAILTEDGRVFVCGSNSEGQLGVGEGMRSCSRLTELKFMERIAFVECGYYHTVFITEKGAVFVTGDNENQKLGIPNTATTIYSPEVLPLNVPIKSACCGANHTFLLSMDESQILAFGSNEKGQLGMPQEVENVTTPTEIDMEKMFDGYQLKLVACGAMHTAFVTDNGLLYTCGESRHNKLCLEEAEDVNNSNEAVPNQYTPKRVTAMDGYIVDNVSCGGCHTLLTATKSSHDDLLNNGLSTSQEQTQKISLIELPPLQKIPGQKIGDMLPGDVLNSNFNENHTDTVNANNHEEIGSIDSLEANVSGSHIVNINDLDETGSTHGIPDINKDDIHSSSVVKAEMEGTPSPALLEIETKDILRNPDKLIDESKQGIEDVIHNLEKDTVLKMEVVEDIIQKTEAKLNPFHNDEKTTLEIPDKTSEIANSPPPKSPIIQDLLHIPDITQMSPNLSTHSDDGQKSETGQSENETILCASDKSSPQAGKTKTQAVMPIVRSEDHIDSNEDAHNEDVVVENKLEEKGRFARLFQSIREKENSCMGKGKVIEEKVIENVHKGLDTAEETVHKVEERVETEIRNQTNSRTCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCU6</accession>
    <name>A0A194RCU6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCU6"/>
    <dbReference type="STRING" id="76193.A0A194RCU6"/>
    <dbReference type="InParanoid" id="A0A194RCU6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="37222" checksum="B453A7C414569B4E" modified="2016-10-05" version="1">MVSDTSNERVGAAGWRGALDFIGGVSLELISRNRSRSRQQRRSSSRARSASRSRSAIRGLTPKGRAGLEDQHDDMPQLVRRNSFRGRGRGGIQTRLLRSNSNARTQNGVHSRLGITNRRGGSNNTYRPLAVAKRGIAKRGLGYATRNKYSNVGLRSDQIIQEQRQNLMLNNSIIKSQTFTRSRRNSFNSPSQLTVSVANDFAKRRRNSVGNGNYLNSRSLAQLNNQFGGYRTRRGPGSVKSMGSNRSNRSSRSNQSNTSNRSRGRGRGRGRGRGINRGVGRKFVNKQILNPKLQKEIAAIQGKSLATNSSESEVPIGVNFTPTPAATAQTLHQRFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCX9</accession>
    <name>A0A194RCX9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Pancreatic triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_10950</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCX9"/>
    <dbReference type="STRING" id="76193.A0A194RCX9"/>
    <dbReference type="InParanoid" id="A0A194RCX9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="6 15" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="13 15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 15 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="19">
        <location>
            <begin position="68"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="804" mass="90730" checksum="D7906E4927AD08E8" modified="2016-10-05" version="1">MLAQYDLVHMENHISPEDLEEFLNWHHKKHNGTDTSTDDYGSMEPVTDFPESEEVDCFGLGSFASQLINMRPDTSENINTHFYFSSRQNPNRVQVFPGDQFGLEWVDFKPNRRTIMIVHGFMSHSNASWVTAMTNAFLQWGDVNVIAVDWSQGGNTWKYWRAVANTRTVGGDVTGFMQQLMKETGANAKDFHFVGHSLGAHIVSYVSYHLGRVSRITGLDPAQPCFRTNNLVERLDSTDADFVDVIHTNGRLLSKIGFGFPDPTGHADFYPNGGMKQPGCFNTTSSLWARLLPIPVGILQQAVCSHGRAYLLFIESLVNNNCSFRGHQWNLTYEGVNASIVAACDRVGACSEMGIRAIGGNGLPRATGAYFVLTTATEPYCPTDWERRHPQPELLRDLREGFRLDRSVKAVVTDTYADPMATKPPPAKSTFFSWWQTSKRPHEFAETFTIADALPTANRRRRRRTKREYLTFLCISSSIKSTSPSHPKDKDKTTKIRPPVPHSSDEMRNCFHLTPVFCVDVVHKQCEELITDCSFNHKQFRCCDKFFPVDSESGPGISFNSLQHMENDHDKLFNVNQSTGPGVLTFRLLSDAQISIHSPEELSTKLLDNKFKIDVDLNYHNHVDILFSIVEVENDPLLQFETPNVRGCRYLEEVPNGFMHTYPVYSNGACRLARNTERSYQQCGCVHPVRDISCEKVKLGVDKGNNDSCLPSCVESELTIVHTSMRRVPKQAKRGSLINISMISLPTLRYRKNLLRNDLDLVVTVGGMLGLFFSASVLSLAEAIYLIIRQPNKELLLFTLSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD98</accession>
    <name>A0A194RD98_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD98"/>
    <dbReference type="InParanoid" id="A0A194RD98"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="10242" checksum="93E1AEB7B2DF75F4" modified="2016-10-05" version="1">MAPVHKMAAPLVAGEIRERLIYFFSYRFIFTTLFHDLIRLYRYCVNRGRMVLPERGAGVCLFLEDELDEGGVEVVSDVLVLLLLSHKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDU3</accession>
    <name>A0A194RDU3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATOR2 complex protein WDR24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDU3"/>
    <dbReference type="FunCoup" id="A0A194RDU3">
        <property type="interactions" value="1265"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDU3"/>
    <dbReference type="InParanoid" id="A0A194RDU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="705" mass="76900" checksum="E70309890B54CFF4" modified="2016-10-05" version="1">MIPSNTICVSQEGPANALALNKDCTQVVIAGRNVFKVFSIGEDEFSEVCNLRVGKNLNLNFSSIDVAWSTIEENTLATAATNGAVVVWNLGRSGRSKQEHVFSDHKRTVNKVSFHLTEPSLLISGSQDGMMKCFDLRMKEVWDMHGKPNLEYTIYTIASVGHVKWRPQKKYQVASCALVLDCAVHVWDVRRPHVPLATFAEHRDVTTAIAWLSPAAFLSTSRDCSLYRHRFLEAAHPVLWANPQSVCISARGEVVHAVPECPLPALAAPPAATPAPPADRHVPGLGRKQPTAGSLSASAQAALERAFPGGAASVVARHWPAPADALLHCARRYRMRGEPPHMLAKHNAAVAREAQRHCVEHVWEVVRAVCPPAKFAKQMRDDEAGCGWVSAASAHYVDVEALDWTLPEEAFPLRSAPPAPLALHALPHHAHLPHLAHLHHHHHHHYDDIEHDGVLGGAGCGSSSPGGSSSGASGGSGSHDAAHRTYSHQNSISTMEEVEGGEGGEGGEAGALSVRVGEERSARPDVAPLLAQALQLHAALGDVQTAAVVCIVLHEHRSDLFSYIEESLQEQWLLGYIELLQRHKLWNVATESVTKPDWDRGDHSKWCDRQVVRCAWLSSVWSLSQQSSSVAACCGRCGRRTRTRAPCERCAPRRPDLCAVCHQVVRGLYAWCQGCSHGGHLLHMRSWMQQHRICPAGCGHYCQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE51</accession>
    <name>A0A194RE51_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exostosin-2</fullName>
            <ecNumber evidence="6">2.4.1.224</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_06063</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="6"/>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE51"/>
    <dbReference type="FunCoup" id="A0A194RE51">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RE51"/>
    <dbReference type="KEGG" id="pmac:106709701"/>
    <dbReference type="InParanoid" id="A0A194RE51"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="21">
        <location>
            <begin position="104"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="22">
        <location>
            <begin position="452"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ16108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="714" mass="82915" checksum="9F43E11876A4B236" modified="2016-10-05" version="1">MATETLLKTNKHSKYISYRKILYHRFFVGLLLFIVVSLVFTVLFNIYAGSSPRTEIYEPVSLDLVSLQVTKIKINAPYSAPRYTNCTYWSCFNVYKCGRGGHDKITIYIYPLREYRTEEDRLISQLSKEFYEILDTIRHSKYYTANPEEACLLVPSIDTLNQNTFSSKHVSQALQSLQYWNNGENHLIFNMLPGGAPNYETVVDLNTSKAIIAGSGFNTWTFRYGFDISIPLYSDVARGIDNTQPEQKNFLIISTQQNIPEDYLAELQNIASSSNDLLLLGNCKTESNRIDHTKRCEYTTGRIFNYPDILKEGMFCLVVRSARLTQSVLMDILASQCIPIIIADTIVLPFNSHVDWHRLSLYLPEDNIKNLLRIVHSVSKERRGELYWQLRWVYERYFATIEKITLTTLEILNEKVFPLAARMYEDWNMPEHLYGPVNPLFLPVTAPKSPGFTAVILTYDRVDSLFTLIKKLVRTPSLTKILVVWNNQKKPPPPSSDWPVINKPLKVIRTKENKLSNRFYPYDEIETECQLTIDDDIIMLTPDELEFGFDVWREFPDRIVGFPSRLHVWDNVTSSWKYHSEWTNQISMVLTGAAFHHKIWSWYYTYKMPVEIRTWVDDHFNCEDIAMNFLVANVTRKPPIKVTPRKKFKCPECTNTEMLSADARHMSQRSACINKFTKIYGHMALKAVEFRADPLQYRETNSGVPQLYPDIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFR0</accession>
    <name>A0A194RFR0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pleckstrin-likey domain-containing family J member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFR0"/>
    <dbReference type="InParanoid" id="A0A194RFR0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="15053" checksum="98C3736BBB132762" modified="2016-10-05" version="1">MKCNIRELALLSDKPCVMEGRLNYKKITNGGYRNQAAVFKERWFRLINNYLFYFKISEMGKFDTKVPAEMNPEKRHLFAARSEDNVVQWVMKLRECSYEYLRNRLHTLQSKIYSITGKCSKRGGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGT4</accession>
    <name>A0A194RGT4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGT4"/>
    <dbReference type="STRING" id="76193.A0A194RGT4"/>
    <dbReference type="InParanoid" id="A0A194RGT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="15527" checksum="5C17BAE173CFB606" modified="2016-10-05" version="1">MTSEETQIPEELKGCYENLIVIDIGANLTNKKYGRDLDSVIQRAKDAGVQKIMVTGTSVRNSKEALRLTRLYPGTIYSTAGRIQNGPALLVQNYNHTEDRRKVDGYHVMSSAKDNVNETCAGEELRSPSLPSPQLITSAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIN8</accession>
    <name>A0A194RIN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIN8"/>
    <dbReference type="FunCoup" id="A0A194RIN8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIN8"/>
    <dbReference type="InParanoid" id="A0A194RIN8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF32">
        <property type="entry name" value="NEUROMUSCULIN, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="187"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="384"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="754" mass="82923" checksum="1F060B64025EFED1" modified="2016-10-05" version="1">MTLWFKDGDRMPIYTVDFRNGPPVHWAVAGEFGARSHFVLNESDPSSAHLAVDKVARYDEGIYRCRVDYVDSPTRNYRVNLTVVVPPESPRIYDSDGQEITGSIAGPFREGSNLLLSCQVAGGKPSPDVSWYRGQERLAITKGGSVCQLHLQRLSREFSGTTLQCRVEPPLLKAQYRDVTIKLFLKPQFVRVTGSGTTRAGHERSFVCTTRGSKPAPNIDWFINSQRIDSAMTEMDVEGEVTRSVLTWRVRREDSGRQLVCRVSNPWFPAYTLEDSVTLDVFYPPVAQISVASPKESHLLREDGDAVLMCSSDASPPATNFTFYKGLQDHLIHDDPIGGISVEGNRLILRGLRRHHSERYRCRARNSEGSGLSEPLTLNVLSRPECSAGSIVQQLAGAPGGEVRARCSVTAPSSRDAGPLRFYWTYNGTKDVLPIPAANITVSGSSSTVIHGLPDSSSDDLGWLACWASNDIGNQRDPCLFRIMPAAYPEPPSNCEIEDEILRCEAGHDGGLPQRFILEALEVRLRDPDPRELDGDSMSDQGISGRGLSETVYRASNDVIPQFPLDALSPGRYTFLVYSETPRGRSQRPAALHSVPIRTIDDLDRPGSLQTMTPGPPQQTPSDNSVALLIGAALALVLLTILTTLCVTLVVMCKKKTRPRRENDESTVLRRSVGVSMYGGSMTQSVMPTVVVRGHRGSRVLAARWSGVLDDTPLAVLALDTRAHVDTDSCRSDMEHQETDLTSNVGDMETQTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL12</accession>
    <name>A0A194RL12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL12"/>
    <dbReference type="FunCoup" id="A0A194RL12">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL12"/>
    <dbReference type="InParanoid" id="A0A194RL12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="19154" checksum="4594FA286E3BABD5" modified="2016-10-05" version="1">MHARDWSKPLSENNPKDDLLHRTTSEGCAEQPQLVLLYFMSQLLLRELAKCHRLVQLVPMDMTSYYENRAGPSNFGNVISQILLCKQITPDFNQEELCSIAKDTQDINRIVNDIQEYLPQHENLNHLETNVALKGEDMNGLWKNKRRGSLYKGMGVLCCMSRPNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMH3</accession>
    <name>A0A194RMH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_07254</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMH3"/>
    <dbReference type="STRING" id="76193.A0A194RMH3"/>
    <dbReference type="InParanoid" id="A0A194RMH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ18530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="27023" checksum="6C01DD0C82ADFA0F" modified="2016-10-05" version="1">MVSLVTGGASGLGKATVERLVKNEGRVVILDIQGTRAQEVAKSLGKNVAVSVGCVSSEDDVKKALELTKSKFGRLDTLVNCAGYAQTHQVYNFFKDKECSSSHFIKCINVNTIGTFNTIRLSAGLIGKNEPNENGQRGVIVNTASTIAYEGDIGQAAFAASTAAVIGMTLPIARDLASQGIRVVTIAPGIFDTPLVQYLPEKVIDFIKRMAPFPPRLGKPEEFALLVTSIVENPMLNGEVIRLDGAQRWFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMM4</accession>
    <name>A0A194RMM4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative serine/threonine-protein kinase CG32666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMM4"/>
    <dbReference type="STRING" id="76193.A0A194RMM4"/>
    <dbReference type="InParanoid" id="A0A194RMM4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF12">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="492" mass="52944" checksum="67FDBBD444C6B113" modified="2016-10-05" version="1">MVSAAIDLPLPWPALLCVDRVAADALRTIYLIRYFQLNLGKFASVRKIRHRVTGEEFAAKFIRKRRRAADSTREIHHEVAVLALCGGCDRVVRLHEVYETRSEVAIVLSLCAGGELQHVLDTAERLAEASARRALRHALEGLAHLHARRVAHLDLKPQNLLLSAGNEDLVICDFGISRAIQPGAHVREILGTRDYVAPEILSYEPLSLAADVWSVGVLAYVLLSGYSPFAGDTKQETYLNIAQCQLSFPPELFRGVSHRAIQFIRETLVLDPKGRLTVEECLEHPWLKDEAGLPRAIEGVGYSAALASDAESDDDTHSVSGVNGHNGVNGVNGVNGVNGVNGVNGVNSINGVNGVNGVNGVNGVNGVTHVNGVNGHNVTNGCNGTNGVHDDKEESECEERDKRQKHAHARDVSPPFPDAPSTPKVSRKSRASPPSVLALCKKFQPDYEKPATLAHAHAHAHERAGGECACAGAGAGCLRVRARPPPDRAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMU2</accession>
    <name>A0A194RMU2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane inner ear expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMU2"/>
    <dbReference type="STRING" id="76193.A0A194RMU2"/>
    <dbReference type="InParanoid" id="A0A194RMU2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032006">
        <property type="entry name" value="TMIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28635:SF1">
        <property type="entry name" value="TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16038">
        <property type="entry name" value="TMIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="19894" checksum="2E4D9C8F24E7B1AA" modified="2016-10-05" version="1">MDPIMDAIKNSGEPEWLEKTVIGGLRVWQIIFLCLAGITSFVVMLCCCFRFRIPRTKQQIEADYQRRIITNKFRQQLETIQDSKMDAMSLQDALELLHEKTHSMEDNQQGSQPSSIMSPQRSSLDASFQPENSQKPEPQVSGVNFVKFATKVAHLSKLGQPKSPTSPTTENKMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNH4</accession>
    <name>A0A194RNH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ELMO domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNH4"/>
    <dbReference type="FunCoup" id="A0A194RNH4">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNH4"/>
    <dbReference type="InParanoid" id="A0A194RNH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="89"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="261" mass="30586" checksum="59926DA4E4E9648E" modified="2016-10-05" version="1">MLSRTQNVKEVVSYLDSTVLEKTFVPANFRDILDPSISIILRVKKINPKLHTTFVSSFRRCLEQIWSYRSLLNDVEDLRTLQFDSNNELHEEKLLKLWSLLVPDTPLESRITKQWQHIGFQGDDPKTDFRGMGMLGLDNLLFFASEYPEISSHVLSHSLHPTYGYTFAIVGINITSMAYYLLKDGSAKTYMFNAKRCLPNIDLFHRFYCYLFYEFDKMWIESKPENIMEFSMIFRKFENAVRSELADPASVFRIKVEVDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNH6</accession>
    <name>A0A194RNH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patched domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNH6"/>
    <dbReference type="InParanoid" id="A0A194RNH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="729" mass="82004" checksum="C609BA271A93B951" modified="2016-10-05" version="1">MIKNITKDEIIRLVNQVKVNPISGHALDYSKLLGGIKYNDTGHIVSAESVLFTWYTHVNMSDEDMNEAGNLVGTEEWQSIQLSMWEKEFLLKMANLSSNVNGLKVYYEAGRSFADVSGETMFHDMDKLFIGILLMFIYAVTALSRCNWLEVRLTLGSVGLLCVGMAYVSAVSWCSIIGIPFGPVHSSLPFLLMGLGIDDMFVMNACWKMVTSSKSSKSVPTKVGLMLKHAGVSIVITSFTDIVALLIGAITILPSLKSFCIYGAVGVFFVFCYSVTFYVAAFTLDLKRIEQNRNGFLFCYTHKKPIALAENKTKCHELFSGFYKYIVLTKPGKTIVILFTLIMTCFSIQSTLKLEQRFDPKWFIPESSYYREFISVYEYYYPEHGQDAMVFLGKINYKYEFSNILNMMEELGNSSYVMDVDPWTEGFYRYVLINYARDLRNNNITDAEFNKYLSRFLFSPVGGRFRASIKMKEPLVCGQPATEIQGSVMSFKLKNFQGPEEYIPAMNYVKNVVKSANITTGDGYRSVWAKVFANWVTDEIIGLEMERNIELALLCVMACTIVLITNLQMCLWIFICVLITIINVLGWMQRWGMTVDIVCCIGLELAIGLCVDYAAHVGHTFLTMTNGSRNERAFATVTSIGTAVLLGGGSTLLSLSLLGASKAYTFQSFFKIFLLVILFGLFHGLVFLPVILSLVGPEAYRSKEHRDASPEAVELDRKNNEKENYSTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ57</accession>
    <name>A0A194RQ57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lachesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ57"/>
    <dbReference type="STRING" id="76193.A0A194RQ57"/>
    <dbReference type="InParanoid" id="A0A194RQ57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF265">
        <property type="entry name" value="DPR-INTERACTING PROTEIN LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="245"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="51560" checksum="E0E4D0A778AC8E95" modified="2016-10-05" version="1">MADSSRRTRAVSLETGGLPLVSTFALLTIVAGQLQGSGYSEQEPEFLSPLENLTVAQGRDIHFTCTVNHLSSYKVAWIKSDTKTILAIHTHMVTLNPRLSVTHNGHNTWKLYISNVEPKDSGTYMCQINTDPMMSQMGHLSVVIPPDIADDDGSAASAPEGGSVALRCTATGVPDPTVSWKRNEGRNIVFRDEDGKENKVVYSYVGSTLVLKGLRREDMGTYLCIAANGIPPTKSRRYEVTVLFPPVIRVASPVVLRATDMQVTLQCYVEASPRALTTWQKGKSQSGGKLLNSSKYIISEEVVSEYGIRMNLTITRLKKMDFGEYTCAAINGYGKVEGTINLKETPQKTTTTTTTTTTTTTTTTPRPTTTTTTRPPKKHLKKQPDRTNHNALDADLRQAELNNALNFYNINTYGANNSHNEYAQRTERQKVRPSGPPRHFVVYNRSPFSTPPLIIFITYWAVHVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQC2</accession>
    <name>A0A194RQC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TIS11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQC2"/>
    <dbReference type="STRING" id="76193.A0A194RQC2"/>
    <dbReference type="InParanoid" id="A0A194RQC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="23803" checksum="53CA476BF2D80206" modified="2016-10-05" version="1">MNSALNSALGAGGGAIGAGWEHPALARAASVPHRALAGLLDRLGHRRLERTASEPAPPPATSRYKTELCRPFEEAGVCKYGDKCQFAHGVRELRNLQRHPKYKTELCRTFHSVGFCPYGPRCHFVHNAEEARRREPPSPGGSLASLSSGSGGSGSGSGSASGSLASYMSDGSRSPRSPHSPHSPALSPAHAGAFAFRRTHSPDPDDERLPVFNRLSSAFGDLIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQD7</accession>
    <name>A0A194RQD7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQD7"/>
    <dbReference type="FunCoup" id="A0A194RQD7">
        <property type="interactions" value="1842"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQD7"/>
    <dbReference type="KEGG" id="pmac:106711438"/>
    <dbReference type="InParanoid" id="A0A194RQD7"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="18"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="535" mass="60503" checksum="1A84FC7177ADD95D" modified="2016-10-05" version="1">MASPSPKSPEQSEKNKQYDRQLRLWGDHGQTALENGHICLINATALGTEILKSIVLPGVGAVTIVDDNIVSDEDIGSNFFLECSSKNLNRGSEALRLVIELNPAVQGYAVQEPTDQILLDNPDFFKKFSVVIATSLSEKTIQNLSNHLWEINVPFILCRSVGFLGSFRIQLKEHAIVESHPDNEQHDLRLDVPFQTLFDYLNSFDIDSLDLKDHGHIPWIVILYKAVQKWKISNSNRWPMSRKEKNEIKAIIDQFKRLDDNGMPIYEENFEEALRAVNTALIPTFLPVKIQELLYSSSAINLTKESSPFWILCSALRTFVEAEGKGKLPVRGTLPDMTASTDHYVALQNIYRNQAAIDSEIVYRKVQEIVTQLHCDHISESEVKLFCRHAHDLHLIKGSSIVGEYQFNNTVSSYIARFLEEPDVMMVHYILLRAAEMFRSEHCRAPGEWEPESDISKLKTCVSKLLTDISCTPFPKDDHIHEMCRYGGAEIHSVSAFLGGCVAHEAIKIVTKQYKPVNNTFIYDGASTNTATFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRK5</accession>
    <name>A0A194RRK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transforming protein v-Fos/v-Fox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRK5"/>
    <dbReference type="STRING" id="76193.A0A194RRK5"/>
    <dbReference type="KEGG" id="pmac:106711422"/>
    <dbReference type="InParanoid" id="A0A194RRK5"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14722">
        <property type="entry name" value="bZIP_ATF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="400" mass="43742" checksum="6D14F2DAD13B3FD7" modified="2016-10-05" version="1">MSSAVPSIKCEESPSPSAPLGAEGETEGAGFKMSINVNLSTAMMNLLAADNVGPALRTPEIVNDVITMTNPLDQYNYNDKSSTFKGGSGNDSNSSMSNGSSATSPASGTPPSIQKTCSDLIKAGLKLSIESKRKMSGSDTDGGLKRFKKEDSDDDYDSSHTHTVKNEGLTPEDEERRRRRRERNKIAATKCRMKKRERTVNLVTESEVLENQNQDLKAQLKDLEVQKRQLIDMLSLHAGSCVKNNSNTRTSPSTPYNMLRTYEPQTFPANFEAQSPYIRPESANILASSYTCVTPLNGDSSIDTISSLDNTYITQQVIDVDFNRPDSVLSLPPNSDPHFINTDGYMPKANLLVPIEHEAEYYDSEVNYNLSSAQPCHTYPGTISDAQTKIANGLNDGCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRX7</accession>
    <name>A0A194RRX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribonuclease 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRX7"/>
    <dbReference type="FunCoup" id="A0A194RRX7">
        <property type="interactions" value="1889"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRX7"/>
    <dbReference type="InParanoid" id="A0A194RRX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="469"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="699"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="796"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="885" mass="102287" checksum="58A2C9EFCC8ECBDC" modified="2016-10-05" version="1">MWYRSSPAELYYKPTPDGIGVMQTSKLEKRCNTFFKELIERGRKARPEVDELPPLRPSRGKACKHRLDDKSSSSSDSDECMDEDGLQGYSDRIMMELQRKQSHPRRLHPEMWFNNTGEMNGGPLCRCSARARRYGMRHGVYAGEETYPKCIPTESNIDKLYHYRITVSPPTNFLIKAPTIIAHDEHEFLFSGFSMFSHYKLAKLPTCKVIRFNIEYTILYVEEPAPQNFSIQELDLFEEYLFYELLELVDLDLGKATETTCSQFHFMPRFVRYLPEGGCEVLSMCEVLKYLIDESGLLIPPDTLEEVHSMDHYKWQKFVDRIKGMIVTYPGKKPCSVRVDQLDRSPPVSKEMKDPNAVKKYYPEIVHFGIRPPQLSYAGNPEYQKAWRYYVKYRHLIANMAKPSYKERQKLAAKEAKLQEMRTQTKMKRDVTVAISSEGFHTTGLMCDVVQHAMLIPVLVRHLRFHKSLDSLEKKIGYVFKKRLLLQTAFTHPSYRENFGTNPDHARNSLTNCGIRQPEYGDRRIHYTRKKGIVTLINIMSRFGKRSETESEIKHNERLEFLGDAVVEFLSSIHLFRMFPGLAEGGLATYRASIVQNQHLAQLAKNIELEQYMLYAHGSDLCRELVMRHAMANCFEALMGALFLDAGLEVTDRVFAMALWHGAPALLDVWNKERLHPLQEQEPLGDRKYIKDFEFLQKLTEFEDSIGVQFKHIRLLARAFTDRSVGFTHLTLGSNQRLEFLGDTVLQLVVSDRLYRHFPDHHEGHLSVNLDYCQAFCNACLFPRLQEFILNQDWNDPKSKLQQCCLTLRSMEGGEPDIPLYKVIECLGPTNTRVYSVGVYFRGTRLAAARGHSIQEAEMNAAELALNSAHGNLTLVTFYTLIYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RTR3</accession>
    <name>A0A194RTR3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_11133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RTR3"/>
    <dbReference type="FunCoup" id="A0A194RTR3">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RTR3"/>
    <dbReference type="KEGG" id="pmac:106717811"/>
    <dbReference type="InParanoid" id="A0A194RTR3"/>
    <dbReference type="OMA" id="VRCIMLA"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="187"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="516" mass="55117" checksum="91516C320F7268CE" modified="2016-10-05" version="1">MLGAVSRVGNGLLAVKTVAEKTLTECSKIAAVSIGNKRDYAAKASAKGQGKVVAVIGAVVDVQFEDNLPPILNALEVQNRSPRLVLEVAQHLGENTVRTIAMDGTEGLVRGQPVLDSGSPIRIPVGAETLGRIINVIGEPIDERGPIPTDKTAAIHAEAPEFVDMSVQQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVISLKDKTSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIIGAEHYNVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFQVAEVFTGHAGKLVPLEETIKGFSKILQGEYDHLPEVAFYMVGPIEEVVAKAETLAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBG3</accession>
    <name>A0A0N0PBG3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOMON domain-containing protein CG14681</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBG3"/>
    <dbReference type="STRING" id="76193.A0A0N0PBG3"/>
    <dbReference type="KEGG" id="pmac:106716210"/>
    <dbReference type="InParanoid" id="A0A0N0PBG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF16">
        <property type="entry name" value="KNICKKOPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857321" evidence="2">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="364" mass="40166" checksum="B242134559E49D27" modified="2015-12-09" version="1">MFIICFTLLVLIAQDCASQDDEGPYRGKFIGKLNSYHHQVSGDVYAVDDLTVLLVNFNYDGTGEDTFFWAGDSGRPGPQGFIIPDEHGKTNILERYNGAEVVLRLAEGKRLSRLRWLAVYDVGTQNAFGDVYVPDEFDPPAPRSLGPLAPAPSAPVVVSSKSVRFLDANTFLIPEFRYDGSGEEVYFWAGVGPQPSARGFIVPNEHGYLEPLRAYRGEDVALELPGGRTVFEVDWLAVWDAAERRALASLLVPDALNVPPAKLRTHPHRTRLPHCKQLHRDYQVAWEVFGNQITIELAAQIEDGEYMAFGVSGNETRSQMLGADVAVAYFNAALQQATVADYNVTAVAPVSIPRGPREYPPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDS1</accession>
    <name>A0A0N0PDS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein patched</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDS1"/>
    <dbReference type="FunCoup" id="A0A0N0PDS1">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDS1"/>
    <dbReference type="InParanoid" id="A0A0N0PDS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113238" checksum="73B76AF29E348EA7" modified="2015-12-09" version="1">MFLKWRLTLWRRVFDLAVSAFEYRLMFDVCAEGGRLEAELKYTAKALGEADSSTHQLIIQTAKDPDVSLLHVGALLAHLKVVQAATRVTIHMYDIEWRLKDLCYSPSIPDFEAYHIEKIFDNIVPCAIITPLDCFWEGSKLLGPEYPIVVPGLQQRLTWTHLNPLEVLEEVRKLKFQFPLSTMEAYMKRAGITSGYMKKPCLDPTDAHCPNTAPNKKSGHDMFLLTHTYVEQAGDVPREERTGLVLKKSGLSVLLASLCNVMAFLAAALLPIPALRVFCLQAAILLMFNLGSMLLVFPAMISLDLRRRSAARADLLCCLMPESPVRTRKLPERSGRSGRNDKSNWKDTTRQPLDPEVAGDEAKTCCISLSLTKWAKKYYAPFIMRPSVKVTSMLALIAVTLASLWGATKVKDGLDLTDIVPENTDEHEFLSRQEKYFGFYNMYAVTQGDFEYPTNQKLLYEYHDQFVRIPNIIKNDNGGLTKFWLSLFRDWLLDLQAAFDKEVASGCITQEYWCKNASDEGILAYKLMVQTGHVDNPIDKSLISTDTKNGHRLVDKDGIINPKAFYNYLSAWATNDALAYGASQANLKPQPKRWTHSPGDVDLKIQKSSPLIYTQLPFYLSGLSDTDSIKTLIMSVRELCLKFEAKGLSNFPSGIPFLFWEQYLYLRTSLLLALACALAAVFVAVMVLLLNAWAALLVTLALATLVLQLLGVMAALGIKLSAVPAGFVTSIGCRRRRASLALESVLAPVVHGALAAALAASMLATSEFGFVARLFLRLLLALVILGLVDGLLFFPIVLSILGPTAEVRPLEHPERLSTPSPKSSPVHQRKTSSSEKPSRTKSAPRPSAPSLTTITEEPPSWHSSAPSVQSSMQSIVVQPEVVVETTTYNGSDSASGRSTPTSKTTHSGAITTKVTATANIKVEVVTPSDRKSRRSYHYYDRRRDRDDDRDRDRERDRERDRDRGDRERDRDRERSRERDRRDRYRDEREHRASPRENGRDSGHESDSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PED3</accession>
    <name>A0A0N0PED3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PED3"/>
    <dbReference type="FunCoup" id="A0A0N0PED3">
        <property type="interactions" value="956"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PED3"/>
    <dbReference type="InParanoid" id="A0A0N0PED3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="47502" checksum="2A0BE8CD2141D545" modified="2015-12-09" version="1">MLKDKQFDIFIASNIGSFKHVKYYIESSKNSKKCLENLVNIKSLEKKDGITAMSWSNDNQTEIILAKKNGVIQYYDTEQGKFTKSYRTDVDTKSVVGLGQHENILLAGVSSGFVKIWGKMNESVVSVGGKIDKMRICQDDTTLFATGGEENDLKVWRLGGEENDLKVWRLGETEPVFAAKNRPQDWLQLRVPIWVSDLTFMPGQGGNILAVCSRYGYVRQVLVGFGRGQLHQVDLRRGKPDKGYKGSVGGVTDIAVNREHRLVVTTSLDRHLRVHSYDTKELVYKLFVTSKPSNVLIQTATSTPLLNPPQFDLKQEDIKVEDSDDMDELFDEMVPVSEKRRKKDLNDSETEITQLEQEIEDIGDMKPSTEGTTDMGIEDSVEEKDAKIMQLLKSTERQKRRIEKRKREKKARSVFHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFN4</accession>
    <name>A0A0N0PFN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Stromal interaction molecule-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_00561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047102">
        <property type="protein sequence ID" value="KPJ21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFN4"/>
    <dbReference type="STRING" id="76193.A0A0N0PFN4"/>
    <dbReference type="InParanoid" id="A0A0N0PFN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.180:FF:000001">
        <property type="entry name" value="Stromal interaction molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STIM1/2 EF-hand" evidence="12">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9807" checksum="553A280E2C015558" modified="2015-12-09" version="1">MEACNNEPACLQDRAGLEAITQLHRQLDDDANGNVDLSESDDFLREELQYDSGYEKRQRAFHHNDDMHISVKELWEAWLRSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFR1</accession>
    <name>A0A0N0PFR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01027286">
        <property type="protein sequence ID" value="KPJ21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFR1"/>
    <dbReference type="STRING" id="76193.A0A0N0PFR1"/>
    <dbReference type="InParanoid" id="A0A0N0PFR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="8124" checksum="F5035790DADDD8BB" modified="2015-12-09" version="1">MYRIKDPRKSLPFYTEVLGMTLLEQMHVPARKYSIFFLGHENPEDVPEDPKERIVWMMSRKGVLELTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5V0</accession>
    <name>A0A0N1I5V0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460955">
        <property type="protein sequence ID" value="KPJ10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5V0"/>
    <dbReference type="InParanoid" id="A0A0N1I5V0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="43" mass="4877" checksum="2F87536BFAE348A2" modified="2015-12-09" version="1">MAWQDQFMTSSQQLTWTGPSNPVYGLRPVSGSQDQLSVRLYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6K9</accession>
    <name>A0A0N1I6K9_PAPMA</name>
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            <fullName evidence="5">Heterogeneous nuclear ribonucleoprotein K</fullName>
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        <name evidence="5" type="ORF">RR48_04351</name>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N1I6K9"/>
    <dbReference type="InParanoid" id="A0A0N1I6K9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22434">
        <property type="entry name" value="KH-I_HNRNPK_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="26775" checksum="26A2DDDB1CA4EF94" modified="2015-12-09" version="1">MSDLRVLKTGARLKIFSSTAPQSTERVVQLVGGKEAVAAGVREVLDLIRQARLDLIPLMYHIYHKAVPIKGAIQNYDPHNYDDYYADEYGGFGGGAGAAGRGGRGGAPRTPRAGPPRAPRPPAPRAAPPGPRGAFNDYGGPPRGFGGPPPRAAPQPPPPPRPPPRTQHATSPFRRRRGGIHQLAGAIIGKAGSRIRKIRAESGAGIEIAEPLPGSSDRIITITGTPQRIQMAQYLLQQSVHESNPNLGRGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I746</accession>
    <name>A0A0N1I746_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I746"/>
    <dbReference type="KEGG" id="pmac:106712941"/>
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    <dbReference type="OrthoDB" id="7413698at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="32826" checksum="196F9EE2B9FA2B7C" modified="2015-12-09" version="1">MAWTNNNVLEFLDLYRKEPVLWDPKNPAHKTRSDIAAAWNRIQNSFSLNCSVVDLKKKKESLMTSFRMHMNRKKKRRGDYQPTWFLFSHMESFLGGNYECDSTNQLQQENFNNPTNAPSHQQMVTEINVGARSNTNESSNNVSRYSMTPLPQANVDKRPKKINNSNYVFVKKDLKEEAQDLKKDTETRDFDEYDLYGQLLAKKLRKLEEHQRDVAMHEIDNIMFRAKMQGSTSQTQNYTSSPSPVHRKMKSPIFIVTQHTHEYEDENIPYQDHMQPQAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8S1</accession>
    <name>A0A0N1I8S1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460689">
        <property type="protein sequence ID" value="KPJ12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8S1"/>
    <dbReference type="STRING" id="76193.A0A0N1I8S1"/>
    <dbReference type="InParanoid" id="A0A0N1I8S1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032063">
        <property type="entry name" value="MavL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16062">
        <property type="entry name" value="MavL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="532" mass="61065" checksum="8B0040D273E2E9E6" modified="2015-12-09" version="1">MDSLRHFQTFAWCKPDWCYPSMGKETNELLRQCTELPAVKLSDDVEEIIKKSKAFPIPFPIETVRIEKLQVRRSIEKLKRNIISTYPLIHERVLLLMTHFLIYKREFGTSIEKLLYKEMTVPELIDRILKKRAITFMGRHDTYKLITGEEGNGGWETVGTLQQKPPLVLENCLSYDEMKLASMVYVSGYTECINDGERTNSGVVKEENAEEDAIIIGLIGPRFQRANRMEYEDILITDQQNSLENGYGEEVTPTTCLNVLKTTYVRNNQSAKHMWRQIWSEFYQVHSYTYEELTSYVNIQDKSEEKRYTDRYVKTNNNFIFDNEVYYKRLCVLTEVALLEAEHRAKEAGTFAFLNVIGCGLGVWMISNHQTDVYILTFLERIRSFLKKDMLDHVSDVNFAFLHPSQGILALFTNSSDVETSTEKRIFFESKRHPKGGINVQLENRQPSSKLSGEHAGKLLVITYPWDGNAHPGNEFWLGSLKTSGDPAAACSTQVSELHNAHINPAVCGHNTRVTGRYGLKTLKEYAAALTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBF0</accession>
    <name>A0A0N1IBF0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 147</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBF0"/>
    <dbReference type="FunCoup" id="A0A0N1IBF0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBF0"/>
    <dbReference type="InParanoid" id="A0A0N1IBF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="327"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="456"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="749"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="817" mass="94664" checksum="568F7583F40A2F38" modified="2015-12-09" version="1">MDADEDGFDSARGVGSGTTEAEKEFEKTKLGRFDDTVSDYITELTDAQKNIERLMAEIEEARCLADAMHARELASVESLDTMKKTLTKLEKELDARKRAGEDDAGATSAVKEKEKFEKEKARLQGELDAIKLRLENALSYIEDLEHRNTAGEENIAKLEEKLEDAENNAVRQNRLVDFIKSESATLKAEMEQRGLIISNLNDKLSKAEKGIERREKQLSSMGNRLEQAQREQEEATARATSLREQLDNTNIKLEQTKQTLVSTTKELKNSTDDNNRMRNDISKLRKQLVQQTKKYQLLEQAKATIESERERLRQQVTVMEREIMLGNKHAEAERREIENLNREKDILNKNIQKIQNEAMDNLQLLNLQEQRRKQLEHEVEVSNAQINKQRLAILQMEKDKDRMLEETIALNDKIDEISEEVRLRTADILDLNKALREEAIKSRKLSVALDATRTERNMLHKNYTEAVDEIQDLKQKLKMLAYQIEQLKEDISGKETGLKTCEGTLAKCNKKNEQLRGEVQAGLTRLADARADITALRQEEARLNRIIQESDVARAKLMKDLEGMMNERDVVGAQLVRRNDEISLLYEKIRILEVTLHRGERQYEQRVEDIRLLRLEIMRLRKEKNLLSKGIENMTDLRLEVFNLERELGRSRLRVRALEEALETPLNVHRWRKLQGTDPDSVTLTHKLRLTQKKVLAQSEQLVLKDRELKETRNLYGAVKDMLALQPSPEIQQTLNRTQRALAQRTTKMKCLIAELAMRENQVTDLRRELDRTNGDLHSFKQKYYEMKRALDADEARRLKVPTPLHPTTPTLQEITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBJ9</accession>
    <name>A0A0N1IBJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor Adf-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBJ9"/>
    <dbReference type="KEGG" id="pmac:106718835"/>
    <dbReference type="InParanoid" id="A0A0N1IBJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="282" mass="32566" checksum="9CE0DCAEA7D78D68" modified="2015-12-09" version="1">MPLNAVGWTTEEDERLVELVEPQTCLYNYFDPSRKNILARECTWQEIATALSKPVEECKKRWRGLRDGFMRSKRLGTLHKTKANIFEKLQFLFEGAEIGEVPVKMDDEVKDDMLIETIVGPEQVITDNQEYYEVSEVTVVEDPQETQLKQNTYIKILPKMDQNSGEPPKKVKRGAGRKKNIPAPRNVPPVKILPKPLVVNGPKTYVRYVEDQKTPEQRSQVIDKLIEKVLKENTNEIDVFFRSMAASVKKLQPNLIPKVKMEVCNVIAKYEMQSFDKNLQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICM2</accession>
    <name>A0A0N1ICM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Transient-receptor-potential-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_01176</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell projection</location>
            <location evidence="13">Rhabdomere membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459786">
        <property type="protein sequence ID" value="KPJ19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICM2"/>
    <dbReference type="FunCoup" id="A0A0N1ICM2">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICM2"/>
    <dbReference type="InParanoid" id="A0A0N1ICM2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033583">
        <property type="term" value="C:rhabdomere membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF47">
        <property type="entry name" value="TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="17">
        <location>
            <begin position="588"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="629" mass="72264" checksum="3A7246A176A793FE" modified="2015-12-09" version="1">MSKKILFQGDPDSECTKQPMDLPVLPKSLTFEEKKYLLAVQRGDMANVRRILQKAHRSNNVDMNCVDALGRGALTLAIDGENLEMVELLIVMGVDTKDALLQAINGEFVEAVELLLEHEELIHKVGEPYSWQKVDPNTAVFTRDITPLVLAAHKNNYEIIKLLLDRGATLPDPHDIRCGCDDCIRDSTEDSLRHSLARLNEYRALASPSLIALSSTDPILTAFELSWELRNLAFAEQESKAEYLELRRQVQKFAVDLLDQSRSSQELAIILNHDSDETPFNEGEHMKLARLELAIVFKQKKFVAHPNIQQLLASIWYDGVPGFRRKSALEKIMIIFRVALLFPFYCCLYMIAPNCETGKLMRKPFMKFLIHASSYLFFLLILILVSQRAEVQLVQVFGSEEMVKDLEKEMLKQRGNAPSFLEIFVFIYVLGFIWEETQEIYVEGIRSYLRNMWNFIDFTRNSLYVAVALLRIVAYFQQTAEIERDPQTKFIPREHWDAYDPQLIAEGLFAAANIFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGKFGFLEQTHGLFQTVANDSFKRLTYCRLNQLLWYFAELEKQKCYVLPGGLPDWDNAGDSCMKWRSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID47</accession>
    <name>A0A0N1ID47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Dynein beta chain, ciliary</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_04123</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ID47"/>
    <dbReference type="InParanoid" id="A0A0N1ID47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001810">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000667">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000001">
        <property type="entry name" value="Dynein, axonemal, heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF8">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="19">
        <location>
            <begin position="346"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="20">
        <location>
            <begin position="682"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="815"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1434"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="1725"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="21">
        <location>
            <begin position="1877"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="22">
        <location>
            <begin position="2020"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1453"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2321" mass="263307" checksum="B6A7C856C3746B66" modified="2015-12-09" version="1">MNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFQEAKILARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPGRPEEEVLMRTLRDFNIPKIVTDDMPVFMGLIGDLFPALEVPRKRDLEFERTVKQAAMDLLLQPEDNFILKVVQLEELLEVRHSIFIVGNAGTGKTQVWKTLFKTYQNLKKKPIFNDLNPKAVTNDELFGIINPATREWKDGLFSVIMRDQANIVGENPKWIVLDGDIDPMWIESLNTVMDDNKILTLASNERIALTPTMRLMFEISNLRTATPATVSRAGILYINPQDLGWNPYVTSWIETRKIPAEKSNLVILFDKYIPPCLETVRNRFKKITPIADMAHIQMLCHLLDCLLVPENTPADCPKEWHDIFFVFACVWAFGSAMFQDTNVDYRIEFTKWWVNEFKTIKFPQGGTVFDYYIDSETKQFTPWTEKITKFELDTDIPLQAVLVPTAETIRIRYFLDLLMKNKHPVMLVGGAGCGKTVLVNEKLQSLSEAYAVQSVPFNFYTSSEMLQKVLEKPLEKKAGRNYGPPGNKTLIYFIDDMNMPEVDTYGTVQPHTIIRQHLDYNHWYDRTKLTLKDIHNTQYVSCMNPTSGSFTINPRLQRHFCVFAISFPNNEALNNIYHNILSQHLVNPELRISGQVAKLSNNVVTATIALHNKVSQVFLPTAIKFHYIFNLRDLSNIFQGFLFSTNECLVGPSDLIRLWLHETHRVYGDKLTEDKDIDAFLKMQDIDEGVVFDKPNIYCHFAGGIGEPKYMPIESWDQLNKLLTEAMASYNDLIAAMNLVLFEDAMMHICRISRILESPRGSALLVGVGGSGKQSLSRLAAFISSLEVFQIQLKKGYCVSDLKHELSGLYVKTGLKNVGIMFLMTDAQVANEQFLVLINDLLASGEVADLFPDDEIENIISGVRNEVKGAGLPDTREICWKFFIDRVRKQLKVVLCFSPVGSTLRVRSRKFPALINCTSINWFHEWPQEALVSVSMKFLEGLHVLPVSLRDSISRFMAYVHTSVNSISKAYLSNERRYNYTTPKSYLEQISLYAKLVNQKTQELQAKICRLENGLEKLRSTATQVDQLKVKLAIQEVELQQKNEAADKLIEMVGVETAKVQSEKALADEEEEKVAVIAEEVAKKQKDCEEDLIKAEPALVAAQEALNTLNKANLTELKSFGSPPGAVTNVTAAVMVLLAPGGKIPKDRSWKSAKMMMAKVDVFLESLIHYDKENIHPDVIKAIQPYLKDSEFEPEFVRSKSAAAAGLCAWVINIIKFYEVFCDVEPKRKALAAANAELAAATEKLKSIKSKVASLEEQLGSLTADFEKATLEKLKCQQEADATNRTIQLANRLVNGLASENPPIPITEGLDPLTMLTDDTTIAMWQNEGLPSDRMSTENATILSNSDRWPLMIDPQTTLVNFTVTRDGLEDQLLAEVVKAERPDLEELKAELTKQQNEFKIQLKELEDDLLSRLSSAGANILGDTALVENLETTKKTAADIEKKVTEAKVTSYQIDQAREFYRPASARASLLYFILNDLNTINPIYQFSLKAFSVVFQKAISRAEPSDEVNQRVLLMSEEISPAELDFFLRFPIKPHVTSPVDFLSNQSWGGICSLASKDEFRNLDRDIETSPKRWKKIVEMECPEREKFPQEWKNKTALQRLCMLRALRPDRMTYAVAAYIEERMGSKYVENRTVEFSKSFEETSPTTPIFFILSPGVNPLKDVETLGKVMGFSVDRNNFHNVSLGQGQEIVAEQAMDEALKNGHWVVLQNIHLVKKWLPSLEKKMESFASGCHEDFRLFMSAEPAATPGAHIIPQGILESSIKITNEPPTGMQANIHKALDNFNQETLEMCGKEAEFKAILFALCYFHAVVAERRKFGPQGWNKIYPFNVGDLTISVFVLYNYLEANSKVPWEDLRYLFGEIMYGGHITDDWDRRLCNAYLEELMQSDLVDGELQLAPGFPAPPNTDYSGYHQYIEDAMPPESPYLYGLHPNAEIGFLTTTSENLFRTIFEMQPRDAQASGASTVTREDKVKQMLDEIMEKLPEEFNMVEIMGKVEERTPYVIVAFQECERMNHLTGEMKRSLKELDLGLKGELTITSDMEDLENSLFLDQVPAIWANRAYPSLLGLSAWFVDLLLRLRELETWATDFVLPASVWLAGFFNPQSLLTAIMQSTARRYELPLDKMCLQCDVTKKMKEEFTIADSRSAPRDGAYVHGLQMEGARWDVQAGIIMDSRLKELFPPMPVINVRAITQDKQDLRNMYECPVYKTRTRGPTYVWTFNLKTKDKPAKWTLAGVALLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID55</accession>
    <name>A0A0N1ID55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESF1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460842">
        <property type="protein sequence ID" value="KPJ12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID55"/>
    <dbReference type="FunCoup" id="A0A0N1ID55">
        <property type="interactions" value="1671"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ID55"/>
    <dbReference type="InParanoid" id="A0A0N1ID55"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="2">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="462" mass="53739" checksum="B24EED55C7BB0907" modified="2015-12-09" version="1">MSDILKDSRFAKYLNDPRYKQIPKHERKVKIDKRFQSMFEDDKFKVKYTVDKRGRPINETSTENLRKYYDIEDSESSAEESEDEEKQLEEKEEESASAGRFVRRAPSEDKEKHEEQKLVNDKLVRGKLDKKIKNKLLDLDIDYARGEGILLTDSSSDEDSSEEEQDSDLEHEWGELDADAETTDESTRRIAICNMDWDNIKASDIMVLLSSFLPPGGIIHKITIYPSEYGLQRLKEEEVRGPIELTEEKVDELSDDGGNEEGSTYHMEKLRRYQLNRLKYYYAVVECDTVATADKLYSECDGMEYESSATRLDMRFIPDDVTFDQEAREECTKLPDLSRYKPRLFTTTALQQAKVQLTWDATNPNRTEAIKSALDGKIDDLDLKDYLASSSEEDENQSDEEEDSQENVSDNDDPIQKYKMLLQDIEKKEEKKQNKDMEMEITWGLGIKDKAEELVQKKLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDU7</accession>
    <name>A0A0N1IDU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SWI/SNF complex subunit SMARCC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01009836">
        <property type="protein sequence ID" value="KPJ20948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDU7"/>
    <dbReference type="STRING" id="76193.A0A0N1IDU7"/>
    <dbReference type="InParanoid" id="A0A0N1IDU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF9">
        <property type="entry name" value="SWI_SNF COMPLEX SUBUNIT SMARCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="14581" checksum="F80FA0EB49E756FF" modified="2015-12-09" version="1">MVRMVARQQHPLLPPLQHPSNRSLHWTSAMYQYRGGSRGREWTEQETLLLLEALELHRDDWNRVAAHVGTRTHDECILHFLRLPIEEPYLQDATSGTTMTDPTLMYIDPSNIYADPQTYKLTPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDW3</accession>
    <name>A0A0N1IDW3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inhibitor of Bruton tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01011278">
        <property type="protein sequence ID" value="KPJ20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDW3"/>
    <dbReference type="STRING" id="76193.A0A0N1IDW3"/>
    <dbReference type="InParanoid" id="A0A0N1IDW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12504" checksum="2EDFAA335A3B4A4C" modified="2015-12-09" version="1">MSRKTNPVVQSTKKEKDNNKSALVKFLEKDDCTSVRIVKIPNIHRAVSISVDNEGLNFACLQIKPTCGLTSLPELSPSSITKHMASLLETATQDDILHDVIFKVSVIKRNTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEQ9</accession>
    <name>A0A0N1IEQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apolipophorin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IEQ9">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IEQ9"/>
    <dbReference type="InParanoid" id="A0A0N1IEQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF36">
        <property type="entry name" value="APOLIPOPHORINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873910" evidence="5">
        <location>
            <begin position="27"/>
            <end position="3379"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="6">
        <location>
            <begin position="33"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="2771"/>
            <end position="2937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2384"/>
            <end position="2411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="3379" mass="375597" checksum="D1141CB75B040B4E" modified="2015-12-09" version="1">MGTNRISYTTLSVLIIFAVLWRPAYTASSSPTFLPGHTYNYGVDGAVSVFVTGAEKQQTGVKIFGQVSVSALGNCGYSLKVNSMTISGPDGKKYPCPNGIDKVVRFSLQEGRAGAEICAEEGDTRRSLNIKRAIISLLQTEQKPSTQVDVFGSCFTEVSASQEGGATLLHRSRDLSRCAHREQGRNDFITAVYNPTAEIKNTQVLQSTLNVESKEIKNTQVLQSTLNVESKVNNGVPEKISATEEYLYKPFSVGENGARAEVLTKLTLTGTTQGGANPGNCPERRTIIFENPHGAVSEQSNLRNALDALKETSKYLQSEASEKSAGKFAQVVRVLRNTNKDDLMKLFNQVKGNSLEKRVFLDALLRAGTGYSIEASIQILKGRELSGLEEKLVFLSLGNARHVNDEAMKAAATVLDRANIPKEVYLGVGALAGVYCKEHNCHSSKSEGIVALSKKLAAKLQNCKPKTKVEEDYVVAALKGIRNIRHLEDNLVDKLVQCAVDHSVKARVRVAALEAFLADPCAAKIKKAGLDLMKNRQQDSEIRIKAYLAVIGCPCGKSASEIKNLLDSEPVHQVGRFITTSLRHIRSSANPDKQLARLHYGQIGTPNKFNVDDRKYSFYREGSFNLDALGAGGSVEQTVIYSQDSFLPRSASLNLTAEVFGHSLNVLEIGGRQGNLDRVIEHFLGPKGVLRTQKPQEIYDSLVERLEKSKDKVEHGIVRRRRSMKSEVDNFDKKIKAESVPYNNELDLDVYLKLFGTDAVFLSLGDDKGFNFDHLLDQLISVLHDGVNKVKNFQNELRGHLLFLDAELAYPTSTGLTLKLDLVGAATARVDVATFIDIRQCIKSPENAKVDIKLVPSTDIEVSGAMMIDADAVSTGLKVVTNLHSSTGGHLIAKMIENGQGFDINFGLPVEKQEIIVASNELVYFTAEKGQMEKVTPVKVDTQNKEYKGCFDQLSDIIGLTLCGEVSVPFTVSGPEAQTSISKFLARYPLTGPASVKLVLEKNNLRGYHVKGVLRRDGRAGKYGVELLFDAQGCKTGRIQFNGEAVYSNEEKSLRLALDSPFKVINGEVALYTKANREYSLMAKAKADELEYYGRLGFDAHREGSNSVYKPVFEYSLPDNKGKQVVRVDGQIIHDTRSNEVKWNLRNINLVFVQSNDPLDLNGQYKPVPNGYDLDMKGKMGQHTILFGSSLKNSEFKVEFQNTLNPYINFKINAHIENNREVIHNDIDLWYSGDLRNSENRVTLNQFYKRYEDSKEFSIITKNKFEIHCLPLKAKIEAQIDSKKVDIELEGQYMNRKAELDLEARTHVKKPGDYSLKLKAEVDRQGVEAFAKRDIVSADKSNFENYITVKGVGKYELSGVVLHRNKANDMNVGAVGHLKISGGGKNEDIKFDFGVIENANLYSSHGKLSSNKGEFLDFLLKVTRGANANGQLKFILKDSISANGQFKVTDNDGKGNGMIIVDFQKTQRKIKADVKFVVKDPVYNADFDIFLNFEKDNNDKIHISTNNKKTEKSIDSKNKVEYAGKRTEVNVHQSGDLDSGKANANVEVVLPTERCLNLKFNRDFTEKDGTLNGNAELTLTDSERRGAAGSSFTYTGKVTNTNYDKDTLDYEGQIVLRLKNGKNLVKAFTLKNIPTGDGKFKGDFKIDVTGNLIPKPASLTGSATYSDNVLDETYRLKGNYGGDVGLEVVGNWLLKTDGGVKKYVDDSTVSLRLPFEKAHDIKWVSTVQFIQPEKKDFAEFTVMESIQVNSDVYKIDSTGKVSQDNGNAELKVLVPHHDPLVIHGNYQLSSKNDVKGIEAEVQARYGKIKRDVKLIVKAPPRELDLLLVATAPEAEKLKKLELKVNNKNPAPNTYSNVVTIQADDRVYKTESIVVYSRTQPLFDLKYTSPSTTKPSRLYVKGETISSSHGKLELKVENIKDVDIDVTCEGNVQKENVNFKGQANSAAFGLKNYNIEISSKDDGSGKRLEFHAVNDNKNLLSGSTSFISKQEGSKTIIEGSGSIKVKEDQKPANFKYIRTILSDGSETFLNLAIGERSYVAESRVTELEYKTSYLYCEEKKQCANIDLHSKINVIKPGHIEHLVNVDFDLRKLGFAPEFGLQISNEFSEQMLPKYLLDLHVNKNDKKYHMHVYCKPETGLIPAGITVTIPTRILALESQLRYSPSGVLLFPIHGEVALYPDKNRPQQKTAARVNINADTSDSHSSAVAEFGLSHPKLGEELTLKVYTKLDRPQENSLKIETSAVLSHNCFGGKRESKVCLEVNPTHLKFTFDTPLVSVINLEGSAIMKDNLQQGDVKFSLLEGKPVQMHAVARDFQYYEFTTGYSDESERKLSIIGHLQPEKRVDVSVDIVLPGHKKSIAHGALYLQDNVVKSDYGLSKENFNYFVNALKKDLTNLQERVKELGEKNSEEFKRTLDRIKPTFKRLEQSYKEDLEKLVHEITNDETLKEISEALHYVAHFLAKIIDDLLRVTKPMVDKITDLVTDLAEKTKTMYVTQLEPQIKELYANIAAIVNEYFDGLLDTAAHFAALVIDFFERHKPEIEELTNTLTEIFKDLTKLLVAQMKEWRIKLSQIFEELSRQVSDLPIIGILREKWQELAVPEQAIGFLRQAQEQIRQVLPTEDAKNFSDELFNYICKKLQQEKIDEVASLRVLYEKLALAVTSLVQFVRSGLANAGISLQPTFTPVSTQTQLQISIIDVVTIVAFKARDQSSPISVDKMSLPSFAPLSLPSWGGGASASLFTQLLRGDLPDPLAIIRAYRPRSLNPLDEIPAKLRAVVVNGQHIFTFDGRHLTFPGSCRYLLAHDHVDRNFSLVLQLQNGAPKSIILEDKNGVTIEIKDNGQIALNGANHGFPVIEKDSFGFRQPNGNLGLGTEYGLMVYCYGKLEVCYIEVDGFYLGKLRGLLGDGNNEPYDDFRMPNGKISTSESEFGNAYRLAGSCAAAAVPEHTHHQLHHMQLPAACEMVFGGTSPLRPLSLLLDIAPFRQACIHAVSGESEEAVRQACALGRGYAALALSGLLPAVLPPRCVSCTDADKEHNVGDTYELKLPAKQADIVIAVETTVGNEKNYKELLVPLVSQLIDALKKSQIGDIKVYLVGITSKFPYPILYDTDLKLKNAKVQFTDKSRYEQIEMIKTGYERIDAVEEKAVNLFDYIRKSLGITNVIAGYRSLLELPLRPGAVKHSISLVSDHCQKQDLLLSTFWSALYSTLYKESAHTHSIITNTPGLADGNDKLKNAAGYTKHSVLICGDKKHKDTEALRATIKPTDNECINFVESTDGFVFSASNYEAMNPGMQKQFLQTAAGAISKEMLREVLVQECTCTYVDPFRVRSVCFTKERKEANTNDDLILNTKVFLNLYAVLRNKESFLFAGSQKEVNVPSAICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF72</accession>
    <name>A0A0N1IF72_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF72"/>
    <dbReference type="InParanoid" id="A0A0N1IF72"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="9203" checksum="2CB8DB430FC804B9" modified="2015-12-09" version="1">MIKESVSFYQFTMKRRPEDHVVKLGLNLPTTTRDRGRPPTTWLTTIQKDLKEFDLDEQDPRNRAVWRIRTRKVYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFD9</accession>
    <name>A0A0N1IFD9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
        <name evidence="16" type="ORF">RR48_03074</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFD9"/>
    <dbReference type="FunCoup" id="A0A0N1IFD9">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFD9"/>
    <dbReference type="KEGG" id="pmac:106713340"/>
    <dbReference type="InParanoid" id="A0A0N1IFD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="127"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="412" mass="47342" checksum="9D62E082548B5681" modified="2015-12-09" version="1">MPRGRPKQSEDQDVKDKKEIKSETQNVKTIEYEAIKKEENSSKIDLNKFKFEKKPTIKIEFENDEETQKTDYKSLWEPPNWRHFLDNLRMMRSNNDAPVDSMGCHMTMDENAPPKVIRYQTLISLMLSSQTKDQVTFAAMERLKERGLTVDNVLAMTDDELGKLIYPVGFWKTKVKYIKKTTQTLKDQYDGDIPNSVEKLCKLTGVGPKMAHICMKVAWDKVTGIGVDTHVHRISNRIGWVKKPTVTPEDTRKALESWLPFELWSEVNHLMVGFGQTICLPLGPSCDKCLNKDICPSSGKLKRSSPNKKSPIKNTPETNSELNITEEPLQLPQKIKVECFKVEEKDVGVQCQSQNVSISELEPKDKTVVSSQKRQLKRQSPRNKIINENETLTDVKESKINLRVKKKKSYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG23</accession>
    <name>A0A0N1IG23_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein unc-79-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IG23">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IG23"/>
    <dbReference type="InParanoid" id="A0A0N1IG23"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1677" mass="185794" checksum="DE61E25F06FEC1E1" modified="2015-12-09" version="1">MQGSFRIQLINMGTRAAAFTAKIRSLYDFQLRLMHNIPPLPSGIDIANTVKYFSQTLLSVLKDVPRSPLEMIRDADSDAERMALYPNLDYKGMFNAISQLVDSAPHIQYGIQAFGQAVLQCLGCLLPFLEYDMIDNLPYMVAYCVAVFPACLHQEILHLLCYYILPFTITRRYSGMEEESQASQSVGAIIMMVFQHSNNPAHHCQLLECLMSMKQQTVRDVLCVVAHGTWGARLSAAKLLFYYWPPFDANLFDRKGLLCKFSNDLVPFLCQRDMCPNAGSAEAAKVCYDHCISVTFASDTPPPLYLCIECANEIHREHPNQRFFDILHPQQQVSMVCENKNCRSTDKSAYSICFSNECASYNGNHPIRYCQQCHGNRHNSRRGGDHVTHARLPPAWHMDSDMQTNLVEAIIRRVHIKKGKTIWFQLPLIDHLLKEAKPINMEDPDSGSEQLGPPLCVQLPDPISVEDRQLLGRYGVWLMVGLCTPNPDTPEEILGRLLSVLFHWFHVTSFSYTGEIANTVEKLKLEHVCGWVRLVAESHARVLLHCLLPHPPPHARHAGHWDTLASKTQHLKEGLNRLYCLIPYGIITQSIWDSIMPAWMEAICTDVPEKELMELKVPVGKILEADGGMGCLEERNLYSFASQRVGSQPRPEAVLPVLDWFQTISLLEVKIPLSQLFDLFSHCVINMPENLVKAPSESVKSKDTETNGSSEGTDKEKEKDKDKEEEIKPQNLTCCILMLDILLKQLELQQSRINIQNVSSEATRLLRLMLKANQANTIEHAQCLAGGACSYCSAAALCQQLGVRLVRALVPHTTRHNEPSIEETWCETQMKKNQSEEERSKSGGTPAASVDGLMSIAGAHAHAHAHVLGDKSSVGGVLVHMPHIMTATVETITEQLDMAASLPPAERPPLATAHTVTLTDTDVATATADISTPNLLGDHEATGESVEEDMTNFWPTSAGKFHFCIDELPQELQYIHQLLQCLQVLVLNTDALAEHRGFLIWCQENLLIDNLWNVCDASQSHISSVAVPILLHCVTLAGGADVLCALVRDSFHQPDPKKRFTAVERVILIIRFMDGSPIRSSLPLQTALATAFCYLITSMDDICVYVAQRATLYIGTIHDSAIELLLYCLETQFDLVIVDRPTVLQAVYQLHNTLSDRRILTWDFFLNRFETLLLEAQINSNKTLDFANLREVVGGDTSSEWLVHKVRRAHEALSVSARAAHVHTLSGSLSAKWPYKRTVSAPAAVPPPPHDVRLEREKVYSRQYSAPLLKRKTSRFGLGQLLAPQPLAARNNNIHEGFHTLSGRSPDEALPIFLPKVDIDETDKETTNLLVFLLMQFLSRSDQAHPSEDKATQRTQDLVLKHLFQLLGYNCNEKYFHVSPHAMRKSSMFNAFMANLPQVLDQNHVMGGSIAEPTLLVLQYCCSPASGSAGGAGGGAGAVGGAAGAVGGAAHSHTLAALEPHVRRNWLLALIVVLYKYHYSGGALCGLAVGLVRAVLNSVEAQYHQCKRIPPMLLLPHLHHAPPVPPPPPPPPAHHTPPQPAHPAPPAHPAHPAPHATQTPRNTREASQPSLKTEEGNASQKSPSHWSDPPEPAKYQQWSVEQESSESELIAIPETSDKSDTTGSFDEPSHCEDPPRIDVHSVCVQPPHAKPPVSGTRSGHHLSTSSSVSIGSDSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH54</accession>
    <name>A0A0N1IH54_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger protein 113A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH54"/>
    <dbReference type="STRING" id="76193.A0A0N1IH54"/>
    <dbReference type="InParanoid" id="A0A0N1IH54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="12">
        <location>
            <begin position="372"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="854" mass="92386" checksum="0E79FDACB69489E3" modified="2015-12-09" version="1">MAGQIHTVDIIVATRYACTENTTRVDDSTSCTEGVQRKLIFLAALALAQSRPPGGEWYDADEKSVIISDSCPDAKEHFLLPHEYDCTKFYYCEYGVKWTTPRNCAPGTHFSFEQQVCIHPILANCTLPGSSTVSADTTATVPITTTTTTTSAAPTTTSTTTTTTLAPTTTTTTPEPTTTTTSTTTTTEAPTTTTTTQAPTTTTTTQDSTTTTTTQAPTTTQDPKNGCPADFHIHKLLPHETECDKFYYCVHGQKVQRRCAPGTYFSFKEQVCVFPWDSECVNNGGGGGGGGGGGGGGGGGGGTTLPNGCPADFDIHQLLPHENNCSKFYYCVYGEKEERECPPDTHFNPVLQVCDWPEDAGCITGGGGNLLPNGCPADFDIHQLLPHDNCSKFYYCVHGEKVERDCAPGTHFNPVAQVCDWPHAAGCVGGGGGGGGGSGGGGEEGGGGEGGIGGGDGGGGNLTEGGAHTCLVLSLKSQRQPALSLIEVEIPTTFKKRNIKNRGGRKRKTSSSEEKNSSDSDEQTVVLPTKRPQKPNPNIQSTGGPKRQKPELEDSDSNSDEDKLHGIIISSQYVPTEWLGPYTELVRGYSQPCWSSVNVEVEIPTTFKKRNIKNRGGRKRKTSSSEEKNSSDSDEQTVVLPTKRPQKPNPNMQSTGGPKRQKPELEDSDSNSDEDKISKSRTTLSVQQQRENATATYELDTERDKDAQAIFEKAQKINEELKGQADDKVYRGINNYAQYYKKRDTAAGNASSGLVRKGPIRAPANLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQLEREELEGGGAKEGGDDSDYEIHSDDELPFKCFICRESFTDPVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHI6</accession>
    <name>A0A0N1IHI6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHI6"/>
    <dbReference type="STRING" id="76193.A0A0N1IHI6"/>
    <dbReference type="InParanoid" id="A0A0N1IHI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="229" mass="26067" checksum="4BD6EF28EA975E3F" modified="2015-12-09" version="1">MAGTRTQSTEPPRSTAYYYADLERIKKKNEEINHPIEENDYVETTEVTNDEPVAEVPPLRDRRYQERKMQERKTEETYSTAGTFPMPEPKEKEPLLAELEVVGRLPLTQLDSSSGVRRSRSWYLCCPNVGEEEISRESSWRYSSLRPVTAPPIAGQNGLHLARAHDARLAELHGVIAELVRRRAQDKCARAIPEEEQEVSDHSTMKLGNKKNLRGVKGHPDGTKFLSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJV3</accession>
    <name>A0A0N1IJV3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047869">
        <property type="protein sequence ID" value="KPJ21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJV3"/>
    <dbReference type="InParanoid" id="A0A0N1IJV3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="80" mass="9061" checksum="FE4C69E8E2BCD3CD" modified="2015-12-09" version="1" fragment="single">DLQAAERQVADASRRLQQCERELHEARAVQGKPDRPQQDVPDQQLDLQLRNFQKLKEVAKALDLTISSLNPLRVSESALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INH5</accession>
    <name>A0A0N1INH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Toll-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tollip family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ07013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INH5"/>
    <dbReference type="STRING" id="76193.A0A0N1INH5"/>
    <dbReference type="InParanoid" id="A0A0N1INH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04016">
        <property type="entry name" value="C2_Tollip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14363">
        <property type="entry name" value="CUE_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000036">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041799">
        <property type="entry name" value="TOLIP_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037301">
        <property type="entry name" value="Tollip_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="11">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="29468" checksum="731C3CB117CDD5D5" modified="2015-12-09" version="1">MTSTLPNEADKNEERRRRLLLGPLPAGFLRADGTVDNVDADYQAALALQQQLSGATYTLINVINAKVYMGLTRMDPYVRLRVGHCIYETQTDPSGGRTPRWNKVIHCLLPPGVNSIYLEIYDECSFTMDELIAWTHINIPQAVLNGETHENWYPLNGKQGDGKEGMINLVLSYSVGPAAVATFPPVLVVPSTGMGYAAMPVYPAPHPAPYPAPQPQQQPPPQQVSPEQLQQIEEMFPSIEKDVIKSVLEANRGDKDATINSLLQMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INL3</accession>
    <name>A0A0N1INL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysosomal aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INL3"/>
    <dbReference type="STRING" id="76193.A0A0N1INL3"/>
    <dbReference type="InParanoid" id="A0A0N1INL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009378">
        <property type="entry name" value="H2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06278">
        <property type="entry name" value="CNDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="690"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="892"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="721"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="883"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="926"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ10102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112388" checksum="805BCD7583B39B9D" modified="2015-12-09" version="1">MNSQRLEEIVAELMKPISDVRRSFDTDLCALLEEYLTEAGLRALEASEGDSSGEEIDVVPNFAELALVLQHSASVYGRKVDYLYQHVLRVSDSLHNSVGESVSSGEEQPQTPNTNRRKRKASTNNDFTTIELEECPGCRRELDVSRPPPTLPRLYLQLEPRAPTAYDAQLMDYDGEPIGMLADLHVTWRLQNGFLVDDLAEPPIDNESIGATQRPLSLTELQTEFDNGAPPDSPPRCSTPLPITNGDIKNEHDEEPRPMEMLDLSPILDEPAKKKLKRKRTMSLDDVVSISVTLVISDEQKRRNREEHEFSLPDKWITRVIDKRKKRALIVRKELLAHEPRPPNLVMRLNLDGYKDRGRLKKVWIDCVKEDMRKKGVHSDMTANEDIQRQNSSESGTDQTDWQSWRAEVVRRAALSEGKVVDIQASAALLLKHVQQTQHNQSQDLVHCDRLLSIAKEQTDVSKLFFATLFLANAGNIDMVQGPPLTTNSFSVRLLSTDERLYRTVMQQDSEQPFPRNREEHEFSLPDKWITRVIDKRKKRALIVRKELLSHEPRPPNLEFRGILEPRDIEGFLGWTKSEIAAALLAAKRPDESDDDGFFEQSWFAESPTDDTPSHISPCMTCKKMRKLFVLFLAFAAACASGISRVPLYRMQSVRKHFHEVGTELQQVRLKYAVSGPAPEPLSNYLDAQYYGPISIGNPPQTFKVVFDTGSSNLWVPSKKCHFTNIACLLHNKYDSSKSRSYVKNGTSFAIHYGSGSLSGYLSQDDVTVGGLTVRGQTFAEALSEPGLAFVAAKFDGILGMAFKSIAVDGVTPVFDNMVAQGLVQPIFSFYLNRDPNAAQGGEIILGGSDPAHYRGNFTYVPVQPTYWRFRMDSVTLAGQTFCAKGCSAIADTGTSLIGGPVSEVAALNRALGATPIAFGQYAVDCTLIPKLPRVYFSLGGNTFELDGTDYILRVSQFGKTVCLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFDVANKRLGFAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INU4</accession>
    <name>A0A0N1INU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin accessibility complex protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA polymerase epsilon subunit p15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with POLE3; binds to DNA. Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity. Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction. Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INU4"/>
    <dbReference type="FunCoup" id="A0A0N1INU4">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INU4"/>
    <dbReference type="KEGG" id="pmac:106714160"/>
    <dbReference type="InParanoid" id="A0A0N1INU4"/>
    <dbReference type="OMA" id="FLEYKHI"/>
    <dbReference type="OrthoDB" id="1291358at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000048">
        <property type="entry name" value="Chromatin accessibility complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="14">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14657" checksum="EAAB4835FD48BD1C" modified="2015-12-09" version="1">MSATKSEKDLHLPLSRVKTIMKSSPDVDAVGPEPLYLVTKVTEMFVTDLAKRAHKNTKGNMLEYKHIAEVVQEDDTLDFLREIVPRKITVREYKELMARKAARGDRSDESSEESSEAESSDGSSSGVEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPN2</accession>
    <name>A0A0N1IPN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 4g15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPN2"/>
    <dbReference type="FunCoup" id="A0A0N1IPN2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPN2"/>
    <dbReference type="InParanoid" id="A0A0N1IPN2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="606" mass="69142" checksum="1E60F9BDC1F571EB" modified="2015-12-09" version="1">MLIITIPNKLIACAMMWLTSIAEWRIQIHDRSIGSLTFVTKDQFDNDQKMGYTATENVVQSSTWAATNMFYVLLVPALILWYAYWRMSRRRMYELAEKLEGPPGLPLIGNALDFTGGSDEIFRNIVSKSYPYDRESVIKIWIGPRLLVFLYDPRDVELILSSHVHIDKADDYRFFKPWLGDGLLISTGQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKESGVFDCHDYMSECTVEILLETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFNFTQYAKVQNKLLDVIHGLTKKVITKKKAEFKSGKKPTIVSEVEVAKNGSSSKTTSVEGLSFGQSAGLKDDLDVDDDVGQKKRLAFLDLLLESSQSGVVISDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGIHQDIQDKVVEELDQIFGDSDRPATFQDTLEMKYLERCLMETLRMFPPVPIIARHLKQEVTLPSNGKKVPAGATIVIATYKLHRRSDVYPNPDTFDPDNFLPERSANRHYYAFVPFSAGPRSCVGRKYAMLKLKIILSTILRNFRIHSDLKESDFRLQADIILKRAEGFKVRLEPRKRLAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPV6</accession>
    <name>A0A0N1IPV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin CFT-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPV6"/>
    <dbReference type="FunCoup" id="A0A0N1IPV6">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPV6"/>
    <dbReference type="KEGG" id="pmac:106709272"/>
    <dbReference type="InParanoid" id="A0A0N1IPV6"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874106" evidence="6">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="255" mass="27758" checksum="727A24C32278FEE1" modified="2015-12-09" version="1">MRALVTLFAVGIVAVAGNKVIHPIVGGVETSIVNHPYTASLLYSADLAAYVQSCVGAILNSRTVLSAAHCFYGDAAYSWRIRVGSDFANSGGTVSMTFRILNYPDFNPFYYEGDLSLLQSSSAFIFSDRIRPASIAGPNYNVGDNQPLLAIGWGKSSANATVTERLRQIQVNHINLTTCRNIYRVLAMYPSEVMLCSGWLDTYRGKECQGTTGGPLLHNNVIVGVTSWGEQCVLNHYPGISTRISNYTSWIQANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPW6</accession>
    <name>A0A0N1IPW6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPW6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPW6"/>
    <dbReference type="InParanoid" id="A0A0N1IPW6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="361" mass="42189" checksum="A9AC3EC9E3C982D8" modified="2015-12-09" version="1">MAEDSNRFLTSTSSGGGYSQAKQEQYTLYLRKLHKEFLEIWNESPETTAKISDFEKYKVLGTGAFGVVYLSKHVTTGRYYAMKMLEKEKIVKLKQVEHSFYEKKILCGLNFPFVVYMKYFFKDNVYLYYILPFIPGGEMFSHLRKLGKFEEATSKFYGAQVILALEYLHALDLVYRDLKPENILIDRHGYIKITDFGFCKLIHGRTWTLCGTPEYLAPEIILSKGYGSTVDWWSIGVLLFEMSAGYPPFFASDPMRIYEKIVAGKYRCPSHFTMELKDLISHVLQVDVTRRYGNLKNGVLDFKNHKWFKEMDWDALLNMRLQPPFIPKVKHPGDTTNFEVFEEEKIKESPINLFEDEFANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ28</accession>
    <name>A0A0N1IQ28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neurobeachin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459862">
        <property type="protein sequence ID" value="KPJ19693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ28"/>
    <dbReference type="InParanoid" id="A0A0N1IQ28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="1">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="14085" checksum="A94CFDA8DB727F3F" modified="2015-12-09" version="1">MLLCSQEWQNSLQKHAGLAFIELINEGRLLSHAMRDHIVRVANEAEFILNRMRADDVLKHADFEVRRPVNISTKARLVAPGLVAPGTVSLTSTELYFEVDEEDPEFKKIDPEVSGLWCIIIIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGL5</accession>
    <name>A0A0N1PGL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Two pore potassium channel protein sup-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04503</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGL5"/>
    <dbReference type="FunCoup" id="A0A0N1PGL5">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGL5"/>
    <dbReference type="InParanoid" id="A0A0N1PGL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000090">
        <property type="entry name" value="two pore potassium channel protein sup-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF326">
        <property type="entry name" value="ACID-SENSITIVE TWO PORE DOMAIN K+ CHANNEL DTASK-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="169"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ14677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="374" mass="41755" checksum="EBE688A2ED881D1E" modified="2015-12-09" version="1">MKKQNVRTLSLIVCTFTYLLIGAAVFDALESATEKNRFDVLQAIEGMLIRKYNFTEEDFRVMEMVVLKSEPHKAGQQWKFTGAFYYATTVLTTIGYGHSTPATIGGKLFTMFYAIVGIPLGLIMFQSIGERVNRLSSVIIKALKRALDCKQTTASEVDLICVVTTLSSLTIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVALQKDNALNRKPSYVMFALIFILFGLAIVAACLNLLVLRFVTMNTEDEKRDQQQAEQVIVNAGQVRVDFIHIIEFLLRYVQHHDVFLHSDTSLIPLYIDEDYAPSVCSCSCNCFAPNKSTVRILLQATIKLAISEQAIACQLHTSVADLPLRPQHRRLPNSCGRRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGZ0</accession>
    <name>A0A0N1PGZ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGZ0"/>
    <dbReference type="STRING" id="76193.A0A0N1PGZ0"/>
    <dbReference type="InParanoid" id="A0A0N1PGZ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="32340" checksum="DC7868D4C04FBD61" modified="2015-12-09" version="1">MPYRKKLRLLLNIQSKNNFIRSVVNLAYRVHGKQDLDNPIIILHGLLGSKRNWESMSKKIVHVTNKTVIAVDARNHGDSPHHHSHTYPELALDVKHLMDSLSIKKADIIGHSMGGRTGMVLALTEPAIVSKLVVVDISPISTAGILNDFIPNVLKTMKSISFDGIDDVNKAKAYAKKLLQSKSLNADTIGFILMNIGVTPYKTVGWSCNVEVLSKHFTDIATFPNMSGKKFPGLTLFLGGGESPYIPHEDMKGIKTLFPKAELKYIEDAGHNVHADSPTEFLQIVTRFLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHG8</accession>
    <name>A0A0N1PHG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-specific guanine nucleotide-releasing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHG8"/>
    <dbReference type="InParanoid" id="A0A0N1PHG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="246"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="462"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="629"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1382" mass="156937" checksum="A0DAB9D28814A023" modified="2015-12-09" version="1">MLSPKIQRSVRVNDGQLLALSDRAQYDHSQAGYLHKRSSDNTKWQLRWFILYQNLLFYYESENNTRPTGVLLLEGSYCERLSKSPMERNALFCFTISYRRENQRQYELRAASEVDCVHWVDAIREASFNKLLLQKEELEQKQLHLLQVVESERTSRWQYAQQCDELTNEVKKLRTELCAYKKEHEPATRTTSTTSLSPSDSDEIDPVELRKIKKVQSFFRGWLCRRRWKQIVDQYIKSPHAESMRKRNSLVFKMVEAEEEYLEQMEILVTCFLRPFKMAASSKKPPCTHEDVNSIFLNSETVLFLHQIFFKGLTSRMESWPTLVLGDLFDMLLPMLTIYQEYVRNHHYSLQVLTECKQSQPFAQLLARLESKPACQSRSLETFLTYPMHQIPRYIITLHELLAHTPHDHVERRSLQHARAQLEELSRQMHDEVSETENLRKNLAVERMIIEGCDILLDVNQVFIRQGTLSQVVGKGRRASLQARQAFLFSNHLLLTTRATGGRLHLPPNGRLPLHDALLVEDPSSHDDDDSTSVCSSPGGDPYQGKDFKILVEVKGEQICAHLVAATLEEKAAWTSEVAQCMESAALTELLRACGSCAASASLPACRSDRALFTDDVDIRFSRTLNSCKVPQIRSATPQRLLQRLTDLRFLSVDFLNTFLLTYRVFTDGVTVLEALKQVFYEQSQQEMELAPPPDTVRKTSGASSVSGYGSEYSDRDWQSRFWKASRKSEDEDKLSPYLMAPSRRTSNVSKAEEDNSHLTIPKIMATSSSNETLKGTSPSSPGALSSVTLVGSPKKASPEEGSTKTEKTSPTKDNDKAAAMMKDESIELVDQSDEDIKYKEEEQEKDKPKPKDEKFQISQRFSERVRNMTESPRRLQVRGAAEARRRSDGARDLPAPAHAHAHATQEPRRASDSNAARLPRRSVSERRCTSSSINSDRRRYFGSSEPRSSVTSQVSQMAQSYRRDTNQPKAGVVITSFRQSHRRSSTSTAAVAFAVATSASSNPRSPPPTSPPHNRRDSVISTAATMRVLNVLRHWISKHSSDFWSDERLRGLTMDFLKEIEASPGLLPAEHKAAAQLLRLLERAPDRAIDLKAIFAPPPIPTKESIETLSALEIAEQMTYLDYQIFSSIHSEEFLGQAWTKADKAERAPHILMMTGHFNHLSNLVISEILKKYTLTGRVAAIEKWAAVADIARCLHNFNGVLQICAALSNTSIFRLKKTWEKVSKTSKQTIEKMQTIISSECRFRILRDALHRCDPPCIPYLGMYLSDLSFIEEGTSNYTPDGLLNFSKMRMIAHVIREIRNFQQTPYKIDHIPKVCDFLLDRSLIIPEERQYTLSLELEPRAARGSAGGLAGAPTETVSPAAQRRRRASLAALAPLRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI93</accession>
    <name>A0A0N1PI93_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI93"/>
    <dbReference type="FunCoup" id="A0A0N1PI93">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PI93"/>
    <dbReference type="InParanoid" id="A0A0N1PI93"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13160">
        <property type="entry name" value="PTB_LDLRAP_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF57">
        <property type="entry name" value="RE46159P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="20985" checksum="D96946B82B8C9DCB" modified="2015-12-09" version="1">MKVTPHVTAAATVKYLGQSDARGLWGIKHTRKPVDLMVAAAKALPPGQILPMVKLMITVDGVHVETARLAGKRDEFEHMAVFFNIESISYGVQDLVYTRVFSMIVVKDNADLKGLNPFECHAFVCESRNAARRLTYSLAAAFQDYSRRVKEMQTTPDQEDKPPSLKKRFAIDLRTPEEIEADFETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIA5</accession>
    <name>A0A0N1PIA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peregrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035776">
        <property type="protein sequence ID" value="KPJ21296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIA5"/>
    <dbReference type="STRING" id="76193.A0A0N1PIA5"/>
    <dbReference type="KEGG" id="pmac:106707320"/>
    <dbReference type="InParanoid" id="A0A0N1PIA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="16844" checksum="003F95F0A13E3C8C" modified="2015-12-09" version="1">MYFSKGRGTRSSTSKTPVKATPTTHLEPLQLVWAKCRGYPWYPALIIDPKIPKGFIYNGVPLPVPPQDVLNLKKNHSHEPVLYLVLFFDVKRTWQWLPPNKLEVLGVDKSLDQAKLVESRKPTERKAVKKAYGDAMQFRKQVDGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIQ8</accession>
    <name>A0A0N1PIQ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chymotrypsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_00481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034647">
        <property type="protein sequence ID" value="KPJ21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIQ8"/>
    <dbReference type="InParanoid" id="A0A0N1PIQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012904286" evidence="7">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ21265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="286" mass="31230" checksum="7C9983528F94A936" modified="2015-12-09" version="1">MYILFIVILSSQCSGKRQPLRVYGGEDADQGAYPYVVRLEIRHVNKMANGSMYGKHTHLCTASALSSTWAVTAAHCLTDLQAYIEASSSHSKLVIRYGSVNSSVKDKNRFSKVVLVIPHPMYVSRKTTQGYVVKNDIGLIKTSPMPLKRFIKLSPVDFHTLYGHEAVFCGFGVTTKKISHNEFITGDTLELKKSLQIFKVLINKCMYEPGTGPILCLGHRCGTIATVCGGDSGGPVIHSTGIVAVLSSGYDSIYCGDDSVDTFIDTAGFPCPVGPYVEWIASYVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIZ8</accession>
    <name>A0A0N1PIZ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_05145</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460655">
        <property type="protein sequence ID" value="KPJ12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIZ8"/>
    <dbReference type="FunCoup" id="A0A0N1PIZ8">
        <property type="interactions" value="1990"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIZ8"/>
    <dbReference type="InParanoid" id="A0A0N1PIZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000009">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="21274" checksum="5DCE60BACE8AB855" modified="2015-12-09" version="1">MDNTQKLKCQALVLVLGDLHIPHRCSSLPPKFKKLLLPGRIQHILCTGNLCTKESYDYLKTLASDVHVVRGDFDEAKQKVITVGQFRIGLIHGHQVVPWGDEESLALVQRQLDVDILISGHTHRFEAYEHENKFYINPGSATGAYSPLFRNPTPSFVLMDIQSATVVTYVYKLLGDEVKVERIEYKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKG1</accession>
    <name>A0A0N1PKG1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_00572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the hemolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01061905">
        <property type="protein sequence ID" value="KPJ21625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKG1"/>
    <dbReference type="InParanoid" id="A0A0N1PKG1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ21625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="139" mass="15432" checksum="690A5B7FB15D30D6" modified="2015-12-09" version="1">MSLGSTLNPNDIKEGDDVYFECNIRANPKEHRISWYHNDQQVTQNMSSGVFISTKSLVLQRVMRRDAGLYTCRAANQIGEASSQAVYLRVQLSTGGTASELRYRAASERDYGSLLCRATNAVGRQKKPCVFQIVPAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK37</accession>
    <name>A0A194QK37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK37"/>
    <dbReference type="FunCoup" id="A0A194QK37">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QK37"/>
    <dbReference type="KEGG" id="pmac:106720216"/>
    <dbReference type="InParanoid" id="A0A194QK37"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264398" evidence="6">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="57"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ05938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="30023" checksum="89CA1AD9F244C644" modified="2016-10-05" version="1">MKLVLVSLCCLGALGALGDLVETYEPLELNYHERIGIPRADALRQAELAADFDGSRIISGSPAALGAYPYMAGQIMTLQTGRESIGGGTLISNTRVLTAAHNLFDGRQMVCHVTVVLGSVRIFSGGTRITSNRMELHANYNTNTFHNDIAIITINWVNYSNTIRNIGLASGSNTYAGAWAWAIGFGKTRDVSAASPDLMHVRVQVITNDACRAAFSTGNFVIASTLCISGATGNICTGDSGGPLVANNLLIGVTSFGAGQCEARRPSGFARVSSFNSWIRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL90</accession>
    <name>A0A194QL90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein daughter of sevenless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL90"/>
    <dbReference type="STRING" id="76193.A0A194QL90"/>
    <dbReference type="InParanoid" id="A0A194QL90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13384">
        <property type="entry name" value="PH_Gab2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF2">
        <property type="entry name" value="PROTEIN DAUGHTER OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="567" mass="64222" checksum="52AA7175A163F021" modified="2016-10-05" version="1">MSKNIVFEGWLTKSPPTKRIWRTKWRRRWFALRQSGELPGQYFLDYYADRNCRRLKGTINLDLCEQVDAGLHMERSNNVTLDPKLRGSVFTIQTQSRTYHLEADCEADMVKWVDAICSVCGLQPKDNASDDSEPYRNAYEMSTRNPDTIDPYIPISECITGVRAQNSQRAFTFDSKDIVIRTRRTHEIDPSKINQMYLSQPHIRSNNAEFSENDSNLSDEECKSLNASQSNIRDWAAARTFTKSAPRPIKYGAYHHGPPVPPRPPKTLAMSRGIFQRDYRAPERNNPPEIGHQHLVEGTNTNVQVPAQVQVPAQVQRPAQVQVQAQVQVPAQVQVPAQLQVPSQLQVPSQLQVPAPVPPPVNLTCSIHSMQYSNIVVACPPAVDRALKPRHSSHSIGNVNNLGMQSMTAANEREEIKKEEKKVYIVPVGVTYVNANYFGHSSSPQQSSSGVLECRVHGKRKLEEERREHIYMNLVSIFRRSPPQLHRAMQFNSDRPRSDVLQYLDLDLPTSSPPSNGDKHRKTMESVHGKSWSASEASSAYKTVDFLKTEAFNITRQDAEASRNSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLH6</accession>
    <name>A0A194QLH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Otoferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLH6"/>
    <dbReference type="STRING" id="76193.A0A194QLH6"/>
    <dbReference type="InParanoid" id="A0A194QLH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000138">
        <property type="entry name" value="Fer-1-like family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="277"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="439"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1236" mass="136824" checksum="A7F83165B526B3E7" modified="2016-10-05" version="1">MNVCYRPPLGCPSYYDDILNCEASTSRASDMPGVHGQSGPAQASGSGGASGSGGASGSGGASTSGGPTTSGGASGSGVASTSGGASSSGVVPNTAGPGLATDHAVPSGSGVPRGYGLVTISSGPGSSQSSNAASDIDEDQALEDIERNIANIEQSMKNREAIIDIEPEEESRTRKLKIAGKRILKKGFSMGSDKVVTIAEIEQIPDREPRKRTSAFRNVRSLLRFARNRGQSSGDEEQGLLEPMPGPSSEPDPVVPQTDMSSDEMGGEPPSHMDTPRKRRLRSALDTAGPAALKAADFQVCVTVVEARQLAGLNMDPVVCVQIGDVRKYTSVKESTNCPYYNEYFVFDFHMPPVMLFDKIITLSVLHSRSILRANKLLGNFKLDVATVWNQPDRQFYHKWALLTDPDDVAAGPKGYLKCDISVIGKGDTVKIPPTSDKDEDDIEANLLLPDGVPMERQRTRFIVKIYKADGLPKMNYSLLANMKRAFTGESQDLVDPYVKVSFAGMTGSTSVKKNTYSPVWNEQIVFTDMFPPLCQRIKIQLRDNDPVHPNIIGTHFIDLKTISNDGEKGFLPTFGPAYVYMYGSTRDYSIIDQHANLNKGMGEGVSYRARVLISIRTEIMDSIESPGSDVEVEPIIPITETSFEKNEEFFLFGTVFDANMIDKTLVEKPLQFELSIGNCGNILDGSKESVRRAQDLDVEHLDELSADTGYWQSVTQPLKAISSDKTYYYLPYWDNKQCMHVRSIWPDHRRRMYNSNMISSIIEKFEEGLTDAQLAIESDNGPDNTCIAGLKATLDCVSNACAAYVRHMTGSQPFGNTKLDRERQKMCLNEIETLSTSTRSLRALITKSSIKDRLRTAFSYLNKLKHICEDAQPALPDVFIWLISNGKRLAYYRIPARDIIYSDHPEETGKFCGKMQSLYLRWPGKKATTPSGWAIPAMVRVYLWLGVLQDKKHYIDNLPVGYEVSSELRNADKLRSNAPNTIFYAEKHNFQMRAYIYQARSLIGSDSSGLSDPFARVVIGDSVSNTQVIDETLSPTWDELLVFNDILLFSSIEHIKTDPPTVVIEIFDQDKVGKSEFIGRTIARPSIKAFEDSYERPQFPPSLEWHEITRGDDRAGELLATFEMLEIPYKQDPSILPELPSPKDAVRKPPLDTNKGPILPVPRGIRPTLSKYRIEVLFWGLRDLKRIHLLTVDKPRVDIECAGNIIYSSVIQNAKRNPNFASPIKYVDVELPDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLW2</accession>
    <name>A0A194QLW2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLW2"/>
    <dbReference type="FunCoup" id="A0A194QLW2">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLW2"/>
    <dbReference type="KEGG" id="pmac:106720197"/>
    <dbReference type="InParanoid" id="A0A194QLW2"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ05950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="368" mass="40316" checksum="C18FEEA3C66BF662" modified="2016-10-05" version="1">MASLLTQKSLVIGKLTKYVNDCAKRLSSHFIYYPDNEKPISGETTKMNMMQAINNAMDITLRDDPTAVLFGEDVGFGGVFRCALGLQDKYGKDRVFNTPLCEQGIAGFGIGLATAGATAIAEIQFADYIFPAFDQLVNEAAKARYRSGGQFDCGALTVRAPCGAVGHGGLYHSQSPEAYFAHTPGLRVVVPRGPIAAKGLLLACIRERDPCIFLEPKILYRSATEEVPVDDYTLPLGKAQVLREGTSATLVSWGTQVHVLLEVAQLAEDQLGVTVDVIDLQSILPWDEETVCNSVKKTGRCLISHEAPLTCGFGAELAATVQEECFLHLEAPVCRVSGWDTPFPHVFEPFYLPDRWRCYEQLVKLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM22</accession>
    <name>A0A194QM22_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM22"/>
    <dbReference type="STRING" id="76193.A0A194QM22"/>
    <dbReference type="InParanoid" id="A0A194QM22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="364" mass="41722" checksum="A0A241075F44AE70" modified="2016-10-05" version="1">MKTSWWNLLISEKKFKDEVKSTIPALGQRDTYLVKYIQEDAKDQTTSRPNTLYDDADDLQKQLDNEARDKLKVGKPKTIWVFHLPTPFPDITYLVTTRRPRSAIHHNKSTCKNKTKAEPDQNDWGKTFPECGGRSQSPVDLPLQGFVKAKGGRRLLFTNYNLYPKKITVKNDGKRVVLFGHWDRNRMPLVYGGAAHSRRYIFHSLSFMWPSEHTIGGLQFPMESQALHISAEYGSMKEALDAAPSDPQAFLGIVNIYKFGDHTQKGLREVLRVLRRQSTFNVSATVHPLSYFVPRFKDYASYQGSLTSPPCTESVLWLVRARSLPVQRETITAAQKLRSPYGDTQSFAVRLTQPLNDRKIFLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMU8</accession>
    <name>A0A194QMU8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticle protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMU8"/>
    <dbReference type="KEGG" id="pmac:106719461"/>
    <dbReference type="InParanoid" id="A0A194QMU8"/>
    <dbReference type="OrthoDB" id="6631236at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF209">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264493" description="Cuticle protein 6" evidence="4">
        <location>
            <begin position="18"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77613" checksum="355357C5203D6BBF" modified="2016-10-05" version="1">MLCLHLVLVACLAATRATNSPAATNTTTSAPNNATTHETSTNSTKEILTVSETADPGKVEIVKQIRRLNEDGSYTIGYEADDGTFKIESRDVLGNVKGTFGYIDQDGEIKRVTYSSSGDTTPVPVTTSTTPSTPTMVVRANKTISSTTRRPLATVVYPTRSSIRESATRGTVIQSIPRRRPVPTRPTTNLDTTTEKIEETTSNILNLYKSREESKTRTQISKPTSATVKDDLITKQTTTNLPSTVKPVHEHIDEDEPEGNKANTIRRELPGTSPNPHMLSLQQSVGDDSTDVYGGHQSHGSVRPLFTTTTPRPRFLPLHSLVSARQKLQRHYQDAAEEQETTVEASTGRVFDQQSVVTTNPVPVVHIQSHRDTDDRLYQQPIYRRPQPTVHFRTEEYLRDNPGAPVPIGNQRPFLHFEYPEKVLEQQIEKETPLAHPTKSTVEPVTIPYEMRPVGRIIPIPVDERGVPIQGYQARFVNPYRSTPTPVVYQQRYDPLEEMNAIQAPVSTRDLKRLLQILILRQNRLQSLMDQIVAPGPPYQPLPVYRQNFDYNRHQMARRYMDDDQYDYRYDQQQQYRQDVYSNQMNYDSNQYESQRYVPRRRLYPRPYDAAGSSSNNIEETPEYLPADIREALLLKMLMLAINPDFMPTPAPSTELTTAAPTRKQVRNVQILGEEGSQVKPVHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPN4</accession>
    <name>A0A194QPN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide Y receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPN4"/>
    <dbReference type="FunCoup" id="A0A194QPN4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106718926"/>
    <dbReference type="InParanoid" id="A0A194QPN4"/>
    <dbReference type="OMA" id="DRKRRTN"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="89"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="53285" checksum="38A6CE0E01673A0A" modified="2016-10-05" version="1">MLFTDNDIFNDAVSLSADQYDAIAAMNFNGTLASYLGGRVLILKTFSGESVEVIDEPKSNKTIDIIDVKFVQVAFCILYTVIFVLGVFGNVLVCYVVFRNRAMQTVTNLFITNLALSDILLCVFAVPLTPMYTFIGQWVFGRLLCHLMPYAQGTSVYISSLTLTSIAIDRFFVIIYPFHPRMKLNTCIYIIVFIWLFSLIVTCPYGLFMGIQIIYNKTYCEESWPSDKSRKIFGVFTTVLQFLIPFLVIAVCYTCVSIRLNDRARSKPGAKNTRREEADRDRKRRTNKMLISMVAIFGISWLPLNIINIFNDFCAQMNEWNYYFLSFFLAHSMAMASTCYNPFLYAWLNENFRKEFKQVLPFFESTGGVRNSYHSGRMPTNKSDRVCNGNETIQETLLGSSFNRGPSFKQKVLEGNGKKDNGVEIENIILEDKTVSASFNSRSENVNLQLIDEESRFTELNTKQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ98</accession>
    <name>A0A194QQ98_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosome complex component MTR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ07678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="51"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="319" mass="36212" checksum="FA12596AFF80F91B" modified="2016-10-05" version="1">MPLDYRRFNGPDDSVSYKRFTPDFLKSYDELLCELLEKNNLKDEQSVDEAQRVFAETDTISQAKGSAYVEIKNTKVVCSVFDPREIPHQNEFSHLGQIYCEVKFGPFSCSSQRRPPAPDAEDKALSEALRQAIEPAVCRHLFPNYQIDVFVYIIENDGSCLAAAINAAGLALTDAAVPMYDLITASSMAILDDKMFVVPNEEEEELALKSPESKDINHGVMTLSMLSELSQITSFIQIGSLETDCVIKAMDILEKECKELVPNIQKIVVRNVIKNVKRQQILQESAKEMEEILDEKYNLWQKSLKAKSYLCFFFHIILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRS7</accession>
    <name>A0A194QRS7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein I'm not dead yet</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRS7"/>
    <dbReference type="STRING" id="76193.A0A194QRS7"/>
    <dbReference type="InParanoid" id="A0A194QRS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="432"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="464" mass="51961" checksum="52A6409136CB1864" modified="2016-10-05" version="1">MKIKLFLCIHWRGLLCFLVPLLLIPVHFTFPTEKYQWCAYTLVLMALFWVTECIPLPVTSIMPIIIFPMCGVMNTTTTCKCYINDTIVMFLGSMFLAYAVEQSGLHKRLALCAVRTIGYSHYKLLFAMSFITMFISMWITNTAAATMMVPINFALLQVFEEQNILKIYDIGPDGENIASDITTCYFCASTFSATIGGIGTLVGTATNLVFKGLFNKRYPDAPEYLSFPKFSAFAIPLMLLLEILMYLNMMVIILFSLAILLFFSRSPEIFLGWGDKIVQIFDLADRKFVLDSAAATMVSFLMLIIPSTTQFMEYFKSKETMNQPTGPIPSVLNWKLMDKTMPYSFMFLLGGGFALSEAAKREYSDLNGKIGHILKNLSYLPNFLIILLIIIFTTFITNFASNVAVCNVITPIAMQLAQEIGVNPLWYNIAVGFTSSFCFILPVGTPGNLVVQSAANIPTLKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSS1</accession>
    <name>A0A194QSS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">REST corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CoREST family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSS1"/>
    <dbReference type="InParanoid" id="A0A194QSS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000001">
        <property type="entry name" value="REST corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000033">
        <property type="entry name" value="REST corepressor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000002">
        <property type="entry name" value="REST corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056299">
        <property type="entry name" value="CFAP61_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23150">
        <property type="entry name" value="CFAP61_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1709" mass="192388" checksum="519D066A1F556754" modified="2016-10-05" version="1">MVLAERSSDVRNGKRSRGPSPNGHGSPDSSSEDENAEKIRVGRDYQAVCPELEPVEQRKPEQISDRALLVWSPTSDISDIKLDEYITTAKEKYGYNGEQALGMLFWHKHDLNRASMDLANFTPFPDEWTVEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRARTSLMDVVGEGRNATGSGTGKRESGAGSEPGGSDKDSDNDEKKWINHRGIVRGGKSLTSGGSSLRMGQQGEGEGGGGAGKWCTVCGILCTQTTPHNSQKLCQACLVHARRTGTMRPLCGPSGRRGPGKQQRYKHRLPRGIYINHDDLVAMATGPQPGDPPQPGLINQGEAMLKAMDREIISLKRQVQQNKQQLSAMKRKVGDAGVEELRPGEPPAKINARWTNDELLMAVTAVRKYGKDFQAIAETLGTKTEAHVRTFFITYRRRYNLDAVLREHEADRGSANHIQQGTTSTEGGDNVADNTSGNGTTSPQANAKDEKMEVDSEGVAIGASAEQGGPPTTPPKHKPAKAVELTARNTLFVHLICWNTTYGREIVDNMLRSVFMHDPYLQYIAMVKSIPSNTVLVPGQPRYEMSFRRVQVIERGVPGDKLPTLQIAERNDVCLKLRIRRAVEEDNDDLLPIIERRSRRMRDLYGDYYISELISRHPESERVILVCEHKEVAVGVMCLNTQINFEALEESFELSPFAGLRHLEDKTNIKQSKDGESTLRFIQEELERVDSFNQRMKEKDLSSQVSHLSTKAQLDIMNLLDDDEEELEFDIVNIDTHLLRIPRLLSYEELSKAAMGGVANLSKILDDRRRDSLSFTDDKCVKKDKMKKSLSNAPPGKMPEPPRYSGPPNAFIIELFAMHPDYDESEVSVRFAEEYDMQYLSDILEHAPRKNELLELIESSFSSDVLDTYVLASRNQPVGVVVLSPVEDPISLRVQYALEPEPYRAGSDGNILAGVLSPAIEPHSRWYMRDVLRQSPYTQLFWTCRLLAKGDSSPVRNLMSMASHMTPVPPYRHAGKNDKDKNYKESSAPFALWTVDRPMTSLPKIYINRNIVVVGASRTGLSFLETLIMGPTSPYLTFTNVTLVSQHGLPTVGECLRAADLCVPRDGRYTDRYLKSVPYYFYMDVVPGIMVKIDRQKKCIYLKGGLVKHYDDLVLTCGQQFQHPDYLKEQLARDRLLKEKTINCDKLPMDNPLYRPDRVSAFTEMPENLMLINSLFDANTGLRKLLRMITDLKESFNGLNEDNKIIVYGDCIDAYSCIAALLELGIAADMITFVEPFPPEDTNALRVNCFNNETVDERVQSSISELGIQVYRRCYYTGWRLSGTRIELLHFMTHTQAITLSCFAFFYYGIKAIDVNSFKAITESGLVYDGGLVVGTGFETNDPSVHGAGTCTKYSRRLYAQAHAQKYYCSEDVGEALAALFLQKLDPFMNSIADLDLCPSEIISRYSSSVLGCKSSVYGSTYSNESRFQLPTCRRWQPVMKFYSPITHSATLPGPLYYLKIRRPGIEIPMAVQMALPLQGHTLQTDKNGNYFRLQLNALHCVVLVTCLSKKPFPSENLAQLFGKHEAFFNKLLVRYQMKQIDDLYEFFSQPWMSAMYQMTFKNLMNDINEQDVGTVYDLLKSTFYLFGDNRPPAESEYGIDAVYSGYGPAANVPEDIPSECGQSAAIRDEALGFWKAVCGERIVVAHLSRYLKQNYATNPQYALPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QST5</accession>
    <name>A0A194QST5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QST5"/>
    <dbReference type="InParanoid" id="A0A194QST5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="628" mass="70283" checksum="E9F9CA4D963A0400" modified="2016-10-05" version="1">MAMVRPRSPAVFRPGVVLQRPWHQRVVPAYRSPYVMYRGPMPHRYAVKPHVHFHNAIPGGPWKTGRQPLPGADYELVRAASAPPLLHTHGDTGAIHTIPAPNLSLSEKPIVVADTDTANTEPTTEPVKTTYEVTEKYSEPQVYQMPAKIEAPTGFSKQSSLKTPELQQFVQNGASFPLSAQYGHPSLPLPQNPHLFSIQGLTDISGHQDLLQTAAERLIIPPSALYQNDPNFLQKLQSQLLQQFPAVEFIPYTAEIQPQIQQTTQSELYLLENEVITQQTPISFDLKSDEPHRNIVQRETQEASLLSLVPQPFTLSNVTENITETTIPNDQQNVTDTSETDLPTTTVKYIETTTEQSTTPIYYAQVGQSVGNIVAKGFYSAINDVRAAAALAQVEKVNELAHIDSSTTIKSDTVQEATNESNLYKEERNETSNEIKHSSNDIKFAGAPFEKAAETVNFTYRLLHTQEDSTKNNRNGNVYAGQIVQAMISEDKDFNKGKANVSWRPPLRLFAIPQNKADNPQKLNVVKAKIPPKTKLTFDDKTGEPVLRIYASYSENPIQKEIVLSKLSNIKHVKEAVTRKQDAVNNWNTVTAKPFEKNIPDANQISQFGLKLRSRSDDYIPIFEEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTL7</accession>
    <name>A0A194QTL7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Forkhead box protein J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FOXJ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTL7"/>
    <dbReference type="STRING" id="76193.A0A194QTL7"/>
    <dbReference type="KEGG" id="pmac:106718156"/>
    <dbReference type="InParanoid" id="A0A194QTL7"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20023">
        <property type="entry name" value="FH_FOXJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047512">
        <property type="entry name" value="FH_FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="42053" checksum="385E59C3B01C0F69" modified="2016-10-05" version="1">MHITSGLSPASGEMLDTSLLSLCGAGEQCGAAYFTVDSAVPESSHTVEIEYVYEQPETYVPGGGQVAPNDDLQPIVTDLSPPEAPKKKTMKHRPERPAVDDQETDLTNLNWLQNITNIMGPPQIPLLPISPNPQAKAPPQNTRLHKFNQTIAKCQEDFMMNKAEYQRNSEKKPPYSYNTLICMAMRYNNDKMTLSAIYSWIKDNFKYYRSADPAWQNSIRHNLSLNKVFVKVARSKNEPGKGGFWKLDLAHLEGTKRISCRTHKKKKKPAMATNKPNEDTTAVANILQIQDVTESMSELPVTLHLPEFTLDIQTLPEMEVETNIGANVIVEPIVPSPPLISDPEPDDLSSLLLNPTEWNDLQLDMLDNYLDSCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUK2</accession>
    <name>A0A194QUK2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">JNK-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUK2"/>
    <dbReference type="FunCoup" id="A0A194QUK2">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUK2"/>
    <dbReference type="InParanoid" id="A0A194QUK2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11801">
        <property type="entry name" value="SH3_JIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000032">
        <property type="entry name" value="Putative C-Jun-amino-terminal kinase-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000306">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="367"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="439" mass="48457" checksum="40332F2ACF92D827" modified="2016-10-05" version="1">MADSEFEEFRRVFDKLPQHIKAPSSFYSLVPNVGLVDESPSSKSDGSPEDDKGGVGDAETVNGSRGAADASAANQGDVTDSQCSPRHKNFTNGERKRRKLPEIPKNRKSTVMGSNQPASLADELGALSGGIVRPGGQSRPLLVLKCGYLLDEDSSPDSERLQSLGDVDSGHSTAHSPIDTGPKSLSPTPLQQNVSPTSSCSISGTNYSGNMTTVPHSHLEILEATHRGLYKFNPRHHDELELEIGDPIYVQKECEDLWSEGVNLRTGQQGIFPSAYAVDMEYNDFDPANVKIKRERYLLGYMGSVETSAHKGTAVVCQAVKKIIGDYTGDFETQTCILEVSDQGLRMVDRTRPETKGVKGPCLDYFYSLKNVSFCAFHPRDHRYLGFITKHPTSQRFACHVFRGMESTRPVAESVGRAFQRFYQKFIETAYPIEDIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV63</accession>
    <name>A0A194QV63_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein brown</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_08874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV63"/>
    <dbReference type="FunCoup" id="A0A194QV63">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QV63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="44"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="703" mass="78167" checksum="A3DD2BBD6458CCE5" modified="2016-10-05" version="1">MKELKLPTRNVLTGAIVNWEDDEMAGLNDNPENLTLSWKDLSVYRKKKIQTSIWRSAVYEEVKVLHGVSGVVSSGNLVALMGSSGAGKTTLLAAISRRDKSAITGYLMLNGRLAGADLISRISGFVPQEDLSIGDLSVSEHMEFMARMMMDKRSSAAVRARRVQQLLGELGVMNCTRTKLKALSGGERKRVALAVQLLNDPPILFCDEPTTGLDSSAASAVVSRLRRLAIGGKLVICSVHQPASGVFELFHQVVLSDYLLNDPPILFCDEPTTGLDSSAASAVVSRLRRLAIGGKLVICSVHQPASGVFELFHQVVLLANGRVAFHGSIEQADQFFASLNFKCPVGFNAAEYYVTLLGVDVEKEMESRERIRRICNEYQRSDFATAIENKIGDVKDEIEYFNGTLDPKNVYFERYLTLVKVNYFVQFYWLLWRNFLALKHNNSVWLAEFFLLMFVGLIISVPYAGLFQDLDQRDIQNAEGLLYLTITETIFLSIYAVFITFPSEVPVLLRETASGLYSPLPYYLSKAIFWIPRAVIAPVLFASLVFTVAGLQGGFMNWLGFCFVCVLCANYANAYGSFLSSVFDKMETAALVSVPFELVGTMFSGIYLNLASASPYVSWLRYISGFYYGVESISILQWDSIQTIECKSPGSPCIKTGSEVLRKFGFAEENFWRNCVCLVIMYCVAHVTAFIMVVKRSRGTPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVR5</accession>
    <name>A0A194QVR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVR5"/>
    <dbReference type="FunCoup" id="A0A194QVR5">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVR5"/>
    <dbReference type="KEGG" id="pmac:106716901"/>
    <dbReference type="InParanoid" id="A0A194QVR5"/>
    <dbReference type="OrthoDB" id="10056177at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="42"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="846" mass="94541" checksum="CADB011A320BB747" modified="2016-10-05" version="1">MAKSDDDSKKYSEDDQNMDDESDDSIGCIRRFILGLRINPNLIMLKVTLFVMYGATASLLPYLTIHMQSIGLTVPEISFVYLALPFTTFLSPPITGFLVDRFGEYKPVVITALILNAAFHHSLLLIPHQETPGIMPSAYVMRHPIKRSVEIWWSPCPSRECPDEDEQVDFVLDRCVDHCMLSRPTESPTIDPSDDEDDLDFHISHKIKPPNLSNTSFLNITGDDEDYNDAAFFLIEVHDDLGEPKEQLGIEMERDDNDTVTDFRSRFGEKLLIAQGVNITALDKEDLRCGGLVMLHNMTKLSQQRLETLSADCMVQKCNFRKGGPEICPPDYKESDDKTFYIYFLLRFMGTIMLSAGVTIMDPIALTMIQKYGGDFGRERLFSSIGMAIFSPITGMLIDMRSKQVGYTDYSAAFYTYDVLLLISAGTVAVMPLGAKLPADNLLHDLVNIIKMPHIILFIFFLFALGNFWGFIESYLFLYLKELGAPNFLLGITVTVGTLSSIPFLYGADAITARIGHVNVIIVAFFSHAARLVGYSFIENSWWCFPFEAMESLSVHLMWVAAATYCAMLAPKNLLATLIGVLGMAHFSLGRGSGSFGGGLLIASLGTREAFRYMGLIAFLGGVLYGALHYFWLRKITMTGMREVCEQDTDSGEGDKLNGEPLRKDAETMVSLERLHMITRFNPLGSLRSLPRSSRARLSQGDINDLYRSRSGSSSQRRCSNIEILPKTPQGSASKVDLLRSALEITHQHGKSHISNPVLSNQIRVTHNPYKLANSAPKLTQRNDISQPMLAEYDPRRRDSIPEEAEEEHAAKPPGKTKGHPPPPPTYDEATKEHRKSWHSDDSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVU1</accession>
    <name>A0A194QVU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein lethal(2)essential for life</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVU1"/>
    <dbReference type="STRING" id="76193.A0A194QVU1"/>
    <dbReference type="KEGG" id="pmac:106718758"/>
    <dbReference type="InParanoid" id="A0A194QVU1"/>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="82"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="23644" checksum="D4BD8BA718B43A19" modified="2016-10-05" version="1">MANFRLGEYVYQKEIPVAKINRPVFDDEFLAMKEHFENEMRRMDQEITRFSTNLTNLYSMASSHCSLNSSQSQVPKVQHSNERDLLKNSPLVVGEGEDKKLKLQFDLSQFDPSEVKVTIVDDILMVEATHIEKTPSITIYREYAREVQLPKGLDPDAIYSNLSRDGVLTVQASLSQAQRYPEIEEPRREIKMNKESGVCTRVDVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVY4</accession>
    <name>A0A194QVY4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Large ribosomal subunit protein uL24m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">39S ribosomal protein L24, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_08925</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVY4"/>
    <dbReference type="STRING" id="76193.A0A194QVY4"/>
    <dbReference type="InParanoid" id="A0A194QVY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000007">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KOW" evidence="17">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ09474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="659" mass="73857" checksum="EA328BDEAFC0FB8F" modified="2016-10-05" version="1">MRIFSYLGKKVGDLTIKYSNLPESYIKRSYEQVYWRNPKGYPQYPAAQVARKKYRFTTHRPWTAQFRRDNEPNKLRKKVFLEPVGEWSFFKGDRVEIMIGKDKGKQGIINQVIQERNWVFVEGLNTHLRVNGVTIQSEAPLLVTTGVKLVDPETLKGTDIEWRYTEEGDKVRVSLTSSRIIPIPKAAEETMDFKSKALYIENTDKDTAAADVTKITFQPKLATFEMDIMESMGIKEDRVGKDKKFPGVTIQSEAPLLVTTGVKLVDPETLKGTDIEWRYTEEGDKVRVSLASSRIIPIPKAAEETMDFKSKALYIENTDKDTAAADVTKITFQPKLATFEMDIMESMGIEEDRVPAKSYWTVKMLGRLAPGVCAQVTMVVNNQQTRNMATLKAISIRLKSVKNIQKITQSMKMVSAAKYTRAERDLKAARPYGEGAVLFYERAEVAQPEDEPKQLYIAMTSDRGLCGAVHTGVSKVIRARLSEPGAENIKVICVGDKSRGILQRLYGKHIISVANEIGRLPPTFLDAARLADAVLTSGYDFGSGKIIYNKFKSVVSYAQADLPLFSRKAVEAAPKLAVYDSLDSDVLQSYMEFSLASMLFYALKEGACSEQSSRMTAMDNASKNAGEMIEKLTLTFNRTRQAVITRELIEIISGAAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWN0</accession>
    <name>A0A194QWN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWN0"/>
    <dbReference type="InParanoid" id="A0A194QWN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="633" mass="72745" checksum="2778C2108DE17C2A" modified="2016-10-05" version="1">MKPTDKCIRIRDTNKAKIDVENVIKSIEDKFKIDFKTLPQWKCLIEKLYFVPNYRERKIEEANLRKLLIIQKLCLETTRLTPFDLTDRLIRTVHIWQKSQWINQQKQHKTNSLQNIEGPLPSIQNSVKTADFIDTSFSGLEEMAEEDVILEDNENKENEPNNDQQKESCSSDSKYSVLSYHSLRSGDVHASAVSNATVCHSMNFKLLECYPKELVISNKSPMKQTIKFSLKNTSLDCVFARFKNVTNRNFFKKANVLPYLSVKLYPGLSIGFKFIFNLKQTKEDFLTSLTFLMQYKDGNQNFLSEYCVNISTQFKKPRCTNVSEIVDIPPVYSWHLNPQFGHPCGILTVESRDEHEYDIRIVKHKKDLSEIESCNSNNATMQTTASDSVNEISTSFIQKPSTINEVENNIIDNFMLSLVKDVIEAALDIFVFDVTSLHLPMNSKRKTSVYLSKCEYIGYHQSYFDVEFRNVDTYELIETKTTRVYAEILPHPIEIHPTIFDMSNAPVVHGVCVDHFIICNTHKIFSSTIKIDVSNITKKLITIKPMTVCIQPETSVKFQVRTCPSKQPFDNELKLMIHFTVKIVATGVKSIYDNIPPIFYEIIAPCALEFCEMYDLVPHSDSLNGGPLKDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYI1</accession>
    <name>A0A194QYI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Locomotion-related protein Hikaru genki</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QYI1">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYI1"/>
    <dbReference type="InParanoid" id="A0A194QYI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000086">
        <property type="entry name" value="Hig-anchoring scaffold protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="446"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="504"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="946"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1465"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1523"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1588"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1646"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1558"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1617"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1789" mass="198608" checksum="E458821BB289F0FD" modified="2016-10-05" version="1">MSAGAGNAEGQALPFNQHELLEREGATSNAPLVESNIVGACKLQRNVLLNKTFRSFENKHPARFRHRECPELEQPEIGKVVVSGRLFGNKATYSCPHGYHVVGLQSRSCQADGKWAGQPPACKENIYCLQPPTIEHARHSALPEQATFDLDATVQYNCHTGYVTNGFPRAKCLAIDGQASWYGPDISCEPRSCGEPGDVPHGWVTADCHTFGCRAVVQCGQGFELVGKAERYCQADGAWAPKELPTCVLVTQVQCPPPEAPRHGKAVYTSCAYNSVVSYECKYGYRLVGDATRRCGADKKWSGAQPMCKEINCGHPGLLWNGWLENISSGTGLGASIIFRCQDGMRMEGNGSAICQSDGTWSHPLPKCLAPCVVPHVSQGRVVRLENRTEDNTTQEVTQIVGSSTMVQHGEVILVDCEQNYEFPSNNVAVNCNNGTWTQIPRCQPARCKKMPKFPRNGMVIAPKTEHGMKARFRCKDGFELKGNPIVICSFGNWSGEMPKCEEVFCPFPGYIENGKVFLVGNMGLYDYRPYVKKVVNNKQIMYECEKGYVLSEGPPGATCIGGHWSPRELPKCTLYQHPRIRWSRRRRSITEPEIRHRRSTYLRQYYNNLRRQTDPNQEYVNQLYNKYNHDTEKPTLRHANFKIMKKLDLNLEEDDEMVGSDVGNDEENFPTAVYTVYNVHGEPIGHRLYSYQPVYEPEDEDVVHHEDVAEYEDSGEFDDDSTHITILKGGLFPDHELATKDDITSGINALKHQYFDKYVDKRHKRFSNQNNTDEMKKEIDIDLQSAETSVQTTTDKSKIARSKRNINVEETEREIFTVSPIAKTSGIYHEVTDILKVVPLKLKNDTSNEIGKEMSVIPLQNNRTNSTDVINIFERRDKRTSRKTDRLNQTTASVPKTGREGKGGRTRTQSENLTEGEANLDNKNGTEAGNKTENGEKGKKGRPKSPCEPIESEPYVNIEIVKYGRDPNNTFSSGTIVRVACGKGYGLNLDTNATAKCVRGRWKPDKPKCEILPCHVPTTEYGIYTMAPENGPATGQLSLGLNHGEDKELNETDPVPNGQVVHFSCEYGYNVQGPTNLRCWLGEWAVTSMPECVAAPCELPLLHGATYEAGYRAGLTVAHASSVDISCEPGRSPPATLNCHLGRLQPTVHDFCRPLANLTRPRPTSEYQSGSDIVREDISELEPDLHGKPVLECGPPARVQGTLIYRDGTEVDGSIGLEGYPHGTEITFRCIASIMGEKTTWKLICEHGDWVGKSFNCGCKVDYAITEELEAQSEELLSNNSCTFRNEEPHVVSFFNDLEITETVDFPPGSVIISRCSDIGKYAMTGSQTRKCIGGTWDGVKPTCFGLNQENDYAMEKPPTILFRHSQGPIAQTNDGKLLIYPGTVLHMECLWMRRFGNPKWNVTHYIPDPERKYQEGWTTDPGRDSQLEYRLSILGAVKEDSGIYRCETPARQSHQVEIIVEDVHCPPLPIRRGLVASGVGTRLGTEIRFSCANGNALLGAHVLTCRASGNWSAPLPVCESVECGDVVHDGPLNEGERRPRVTVVSRGVGGRAAFSCAPGWALSGAAETVCLPAADWSKPFPVCKEVSCPALPPPASGYVLGRAPYRAGDVLQFHCNPEHTLHGRPILVCQDSGRWSDKPPTCAQACTYPGTTISGRMSSVKFYYKIGETVSFTCEPGYRIKGAPMLRCLKNRKWSNAIPLCTPIANYTSSELVMLNGDIDAMLSDAAVSVIPDILRTRETPAILTPQSLKAAMTRVAATRLLRRAPIETYKNRISRVNRLLRRDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZB0</accession>
    <name>A0A194QZB0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Component 3 of promoter of RISC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_10058</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZB0"/>
    <dbReference type="FunCoup" id="A0A194QZB0">
        <property type="interactions" value="2680"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZB0"/>
    <dbReference type="KEGG" id="pmac:106715247"/>
    <dbReference type="InParanoid" id="A0A194QZB0"/>
    <dbReference type="OMA" id="DAFHFTI"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000001">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="26929" checksum="174E1F4FFE4FD64F" modified="2016-10-05" version="1">MSGNLVINNIFSEFQKSLDEEQEIREVIRNICKDVDSIYRAVTTILQVIHYNEDGIAPACLQAREMFEKARAGYAKLKDAVPPTDYYKYQDHWRFMTQRFCYLISLTIWLEKGIMASHETVAEILGISAIEEKEGFHLDIEDYLVGLLNLCSELSRLAVNSVTRGDYNRPLQISKFVMELNAGFRLLNLKNDHLRKRFDALKYDVKKIEEVVYDLSIRGLLPKTEPEEVVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZG8</accession>
    <name>A0A194QZG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZG8"/>
    <dbReference type="STRING" id="76193.A0A194QZG8"/>
    <dbReference type="InParanoid" id="A0A194QZG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="454"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="911" mass="102901" checksum="AA3466D8D7CF338C" modified="2016-10-05" version="1">MRQRPGIRIVQCAANRDPETVVKAAIVLFDDTINVTHCPHLTTCNIAVAKVRTAAWEIGVVSVYLEPNKPIKPYLDQIGSVVDKLGTASVVLGGDLNAWCMDWGSQKTDSRGLEVAETLDVLGLHILNQGSEPTFDTVRGGKRYSSCIDITACTTPLLGRVTNWRTDDGVSSSDHRAILFDINLQKSVGMDIRCSTRKYNTRKANWGEFRSKLAPKWREKGLTTEKVREVTSREGLEEMVGRYVETVVEACGETMPGISQRRRAGLPWWSEELSNLKTEVLRKKRRIRCAAPVRRAWVVQQYVDAKERYLLEVKSAQTRSWKEFCGRQSRETMWEGIYRVIGRTAKRPEDIPLVQDGVALNGEESARMLAEVFFPEDSPREDDAAHTDMRNLAEKVNEGSHNEICDPPFTRHELMWAASSFNPKKAPGPDGLTADICLVAITLDPELFLEIANRCLALACFPRRWKEAAVVVLRKPNKENYTHPKAYRPIGLLPIMGKILEKMLVRRVRWHTAPMISRRQYGFMPQRGTEDSLYDMIQHIRAEVERRKLVVLVSLDIEGAFDNAWWPAVRCSLAATRCPVNLRRLFDHYFSERIVRVRYAGAEWTRRPTKGCVQGSIGGPTLWNLLLNPLLVELEDMGIHCQAFADDVVLMFSGDSSTEIQGGANAALDHVRKWGVRNKLNFAPQKTKAMVITRKIKYDSPRLNMGGRSIELTKCMKILGLTVDDRLTFNAHIRAVCTKALSLHRQLSTAAKISWGLNPEIIRTIYVAVVEPIILYAASVWAPAARKKTTQKLLDRVQRGFAQKIVRAYRTVSLNAPLIAHYPLRGQFGIFKKSTMRTRVPRCRPFSTRILAIFLLLLGLALYCIYYNATPSGYNKPKHNEDQGAPLQTFLHPDSGHLLTVAWSGSLLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0E7</accession>
    <name>A0A194R0E7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">46 kDa FK506-binding nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0E7"/>
    <dbReference type="STRING" id="76193.A0A194R0E7"/>
    <dbReference type="KEGG" id="pmac:106715385"/>
    <dbReference type="InParanoid" id="A0A194R0E7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="30340" checksum="9D69CF9B19267F75" modified="2016-10-05" version="1">MFWGLIMEPNKRYTQVVEKPFHISQAAMDISTGDNDPCQVMVVVDGKNFLVCTLQKNKCIQVPLDLYFKMGDSVAFLTNGKCNVHLTGYLDPEYEEEQSDEEEEAESEEEEEAPALVSSKNKRKQLDSSTESSNNKKAKKEKKGKKAAEESSDSDEEEEDDLQKFLDGEIDTDDNDESFKVNTSAEADDSEEDSDEEEEEEEDEDDDDEEENDKGESSEADTTLDTSKDEAKVDMSKLTKSQRKRLRKKMQQGKTPQVNGVEKPKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1G0</accession>
    <name>A0A194R1G0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CREB-regulated transcription coactivator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1G0"/>
    <dbReference type="STRING" id="76193.A0A194R1G0"/>
    <dbReference type="InParanoid" id="A0A194R1G0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024785">
        <property type="entry name" value="TORC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF15">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12886">
        <property type="entry name" value="TORC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity C-terminal" evidence="12">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="633" mass="67958" checksum="93C1245F85875A21" modified="2016-10-05" version="1">MANPRKFSEKIALHNQKQAEETAAFEKIMREVSDATNKVNSSSRRARVVPPPEPVENVDTTLRPTQQMIGTYRSGSLPNVAAPQPPTTEPETKKPEETPIPTQYGMSGGRSGGTSPSRTPVQRGRASSSVGPMRRPADRKHDTSPYGSSVYLSPPPDSSWRRTNSDSALHQSCGETQQPAPPLSPHHPLHSHAHPHLHPHQNHRRGPDIHLDVLATLGMNPTNRPRSSCEIPRIPNNNNVYESGGDDGGGGGGGGGGGGVGGGGLACGELQVPGGSLPDLTLLHYPPHATHTAHYLPHRTSPDYHPRYVDAKEPTENQRRDCLDPTCMIVIQPQSPSSPGAVSPGGGSASPATGGLSPASGSPVGATVPTPACALRTHDHYDAQVSAHRHRDYTHYRDPAATNHLSVPNTNNYLHHNKNMSPLDHTWMTSGYQSHCSPPSQYSSTSNINIPSPTMHSPGSPVESPQTDYNNLHQALLQPFEQITMLDPPTSSYNTNYINHSSPHSPQTTNSQLTYSQASHVQHVQHVQHGQHVQHAQHLQHEPRRARDPVPGGGGYPPLPLASPSAPTGPATPASIPDIILTDYSGELDAGIFGGEEAQLRAGLDLDDLNLLEEPSALLPDSAVEHEFRLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1J2</accession>
    <name>A0A194R1J2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1J2"/>
    <dbReference type="FunCoup" id="A0A194R1J2">
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1J2"/>
    <dbReference type="KEGG" id="pmac:106714838"/>
    <dbReference type="InParanoid" id="A0A194R1J2"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="41583" checksum="3A0844CD5D4AE055" modified="2016-10-05" version="1">MTENTIDIGVLDVLEEKPGWLLHPRFFPSKVGGKPAWLDLKNLCAPADLTCKKCNDPLIFLCQVYAPYEEKDDCFHRTIFIFVCRNGSCCRPNCTDNFVVLRCQLPRKNDFYSFEPYKEDEHEIFSMEEWPKLCNVCGVRGPSHCSKCKKSYYCSRKHQILDWQKGHKENCVELQTCDNVPLPNFTVTEAGKSILFKEWELVVDAEDEEDDNVVDENQEMEKLRKMMNEKRAGTLSNVSESELEQYTRNMPEDKVFNKFSKRISRHPEQVLRYDRGGTPLWITGNTEGALTHIPNCHYCNGERQFEFQVMPQLLNFINVGIDFNSIDWGILAVYSCKNSCNIGPSYKEEFIIKQDLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1L6</accession>
    <name>A0A194R1L6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1L6"/>
    <dbReference type="FunCoup" id="A0A194R1L6">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1L6"/>
    <dbReference type="InParanoid" id="A0A194R1L6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="472" mass="52682" checksum="CA911700E47E742A" modified="2016-10-05" version="1">MDTIKSDKSSLGTNLEKEQLLMNQKPPGVKCDIVNECQMFLKAEDGGGDGARLKITDSISPKIDGENDIVKPTTSKKQEETSEKAIEESKNESDSEVNEEMPSTVTVLDTPDGGKVYLVGTAHFSIKSQEDVSRVIQEVSPHIVMVELCEQRTNILLLDEEIILREAKNINIKKIRATMAQNGVFNGLMYILLLNMSAHITRELGMAPGGEFRRAMAEVIQEVSPHIVMVELCEQRTNILLLDEEIILREAKNINIKKIRATMAQNGVFNGLMYILLLNMSAHITRELGMAPGGEFRRAMAEAKKIPNCVLQLGDRAIDITLHRAIASLTWGQTIRFIWHLLTSNQSISVEEVEKCKMKKMLDDMLEEMAEEFPALKRVFVVERDMYLCHSLQIAAMQPRNEPCRIVGVVGIGHVAGIVEHWGKITAQDITPLLVVPPPSLSTRILRVSVRAACAGAIIYAAYKFFPRRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1X8</accession>
    <name>A0A194R1X8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1X8"/>
    <dbReference type="KEGG" id="pmac:106714401"/>
    <dbReference type="InParanoid" id="A0A194R1X8"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264859" evidence="1">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17209" checksum="DE0510A2736D1CFF" modified="2016-10-05" version="1">MLFNIFLIFGMVVAAHAGIEDNKPILPLDSDLVSLITRKGEICVKESGVSPAIMHNLLPWRVEESEVNGKFLLCLAKELEFHEKDGKLKVDRFFDLFRQSLKSLDVEPYKKLFERCNELTGKNAYYTVYKIANCFHMNSPVKMALHVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R269</accession>
    <name>A0A194R269_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R269"/>
    <dbReference type="STRING" id="76193.A0A194R269"/>
    <dbReference type="InParanoid" id="A0A194R269"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="12870" checksum="041E81DCF0E097BC" modified="2016-10-05" version="1">MWGAAVSNPPHYHYVQGPNGVGPQRGPAGPVLSGPGVKHLRPQSSYSLPHGANGPTRWSWSGSNASSFDRRQAKVPPQPARPAPSRPSHVRNNSTYNVCMDLDEIGIDVEHSLEEHIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2H3</accession>
    <name>A0A194R2H3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2H3"/>
    <dbReference type="FunCoup" id="A0A194R2H3">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2H3"/>
    <dbReference type="KEGG" id="pmac:106714248"/>
    <dbReference type="InParanoid" id="A0A194R2H3"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="343" mass="38984" checksum="B8E382D933FE0F12" modified="2016-10-05" version="1">MSLLKKTFQGAIKISIRSYSANTGLNKPPKILITGGLGQLGVECAKHLRGKYGKDNVILSDIIKPSTEIFNDGPYIFADILDFKGLQKIVVDHRVDWLIHFSALLSAIGEQNVPLAVRVNIEGMHNVIELAKQYNLRIFVPSTIGAFGPDSPRNPTPNITVQRPRTIYGVSKVHAELLGEYYHYKFGLDFRCLRFPGVISSDPPGGGTTDYAIAIFHDVLRKGHYECYLKPDTRLPMMHVRDALRALSEYLEAPNEMLQRRVYNVTSMSFTPEELADEMFKYLPDFTLSYKPDSRQDIADSWPQVFDDSEARRDWNWKPEIDMDNLVKLMLKEVKEKIIANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2L3</accession>
    <name>A0A194R2L3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2L3"/>
    <dbReference type="InParanoid" id="A0A194R2L3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14988" checksum="E53D10C728C5646A" modified="2016-10-05" version="1">MAYLVQIMSPDVLLKRTLLTTLALEFVVLFVGCSFGCEAGSARGGPLRPTERRGSRDARRIHGRCDLPSRQMIDFDQSIVAGYLSTVHVRTTMRISQFRLPRNALADVTFNGRLGFFITAREPGRTIVVYVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3Y6</accession>
    <name>A0A194R3Y6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein ultraspiracle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3Y6"/>
    <dbReference type="STRING" id="76193.A0A194R3Y6"/>
    <dbReference type="InParanoid" id="A0A194R3Y6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="13665" checksum="5E198BE64183C588" modified="2016-10-05" version="1">MSVAKKDKPTMSVTALINWARPAPPGPQPPPSPAPLTMLQPLPTPSSLTNVDYEEMQWLNLEAGFMSPMSPPEMKPDTAMLDGLRDDATSPPALRNYPPNHPLSGSKHLCSICGDRASGKHYGVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4R1</accession>
    <name>A0A194R4R1_PAPMA</name>
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        <submittedName>
            <fullName evidence="3">Death domain-associated protein 6</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">RR48_10433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194R4R1"/>
    <dbReference type="InParanoid" id="A0A194R4R1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="2">
        <location>
            <begin position="297"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="467" mass="53558" checksum="7B1D2D1B8DFAA575" modified="2016-10-05" version="1">MSNVEIIDLLDDSQPDEVILLDDDEEEHELFKENELLSVLYQTCVNKSESNGMMRIFKRMIIPAYKDMDKSYRKETEESAKRKPDSVPDKSKKVKTDVINLDFYEPPVVIVDEPDVLNDDIVYINDENKTETRNVCPQTKSMSNSTNLITSENIENNNGFNPNISKINQENALLIPSSEVCYSSEEVEVQKLEKLMAKFRKKIVELEKREVVNDKVTSPYILSEKYKIALVDMYKRWCELMGTESVRSKKIKLNVQEGHPPGPVRRLEAFLNNNIGSDGCPLFPDFNDVVECVLTSNREDGLSWNKARVMSEATALFTQCGRALQKRRQKQEWYHLMSLVDQEQCLKDPADNDPELEARLQENKRQANIKEIKILETFSLMQEFPSKEKNNGESSKSLTQDSENSICLDVENAADLSKNNIVKVEVKQESLDVIKQLEELGDNYTAVVQDIEDPFLVVEISDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4U1</accession>
    <name>A0A194R4U1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General transcription factor 3C polypeptide 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4U1"/>
    <dbReference type="FunCoup" id="A0A194R4U1">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4U1"/>
    <dbReference type="KEGG" id="pmac:106713761"/>
    <dbReference type="InParanoid" id="A0A194R4U1"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="148"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="53211" checksum="186DC113A2EBF4FA" modified="2016-10-05" version="1">MDPSNLKRNLVCVLFPGIVKNEEKAVQCLGGRRGISQVYSQPTKKRLGLSFQPDNPYVKKTFADCKRTAGVLLKVKVKKTKVDGKDTKQVVSTTLLGSVKVIYKFEAMCDFQYLPVNIEGQEPQCILEKILPSGVDTFDFMLKPSPLFIVPSNFTRFDKPINYNYTDKRFIVKEQDENPDNIHRRARTERGTPLLRYTFNLDDDLATEAHAYYIKQLEIKKVMYPPLQQEFETVKKLFEERPIWSLNLIKFHTKIRLSSLKIIMPCLAIYMKDGPWRMLWVKFGYDPRKEPASRIYQTLDFRLRHTAGVHSMVMTRDKVVHYKKAVRVRQLRNERVEPQPPDDVSEGAVRFRPGMAPSQRQIFYQYCDVHLPEVEEILAVEPPPGYLCHEKRGWLPPDTDQICRDHIFRYVKQTLLATHSADLKLEQGSLESCEEDSSSDDDDEGSIPANETDDVSTLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R503</accession>
    <name>A0A194R503_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-binding protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R503"/>
    <dbReference type="FunCoup" id="A0A194R503">
        <property type="interactions" value="2022"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R503"/>
    <dbReference type="InParanoid" id="A0A194R503"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="486" mass="55526" checksum="1D05AD30D1C255FD" modified="2016-10-05" version="1">MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKKQRQLVRAAVLKMKDPTQILEELQKIDEMEYNVLQPSPLNEKVLKEKRKKLKETFDRVLKMYDKDDPEKWVELKSQEMEYKKRRALLISYYESVKHAQSVQVDDIPLPTLQDKDDPEKWVELKRQEMEYEKRRAHLISYYESVKHAQSVQVDDIPLPTLQVPDNLIYGNVPSQIPLPLDTVHPILPKPILKKDSVYRERPVGIEPPGVPPGPPPNYSVLIFEAMKHESHKEKKSLRFSDFPDEGPPGESLMGVTLEAKVTAPSKVAHEEFDGEAMDEEHSASPPASAHAHKPTSLQQRMLALSGQNIDDFMKEMEEVHKKRERDRAADLNARLNALKRTGGGRDSDSDSDTENHHHMMHHADFALEPPGAEIRQMPPPLLPPGATISAKPQIRNLSADVTRFVPSALRVKREDKKSRPNAKTGALQRQLDVPKAPSKDDAYMQFMKEMEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R568</accession>
    <name>A0A194R568_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R568"/>
    <dbReference type="InParanoid" id="A0A194R568"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11267" checksum="0B57CC9CDCB57348" modified="2016-10-05" version="1">MLDKKPRKRFCYDLFSKRYDGEVHNLTILECSTRFTITVAEVASKTDVGCSAGGVDARHPRPPRPPAPSRPSGRRTPRDKHFIDITALQFVPSILILAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R809</accession>
    <name>A0A194R809_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth hormone-regulated TBC protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R809"/>
    <dbReference type="FunCoup" id="A0A194R809">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R809"/>
    <dbReference type="KEGG" id="pmac:106712342"/>
    <dbReference type="InParanoid" id="A0A194R809"/>
    <dbReference type="OMA" id="DTMIQDS"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000029">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="39039" checksum="9D8BBF3079FE0082" modified="2016-10-05" version="1">MAQSTFSTVDEYGFERHEDFDYESYEHFMSVYLKVLASRAQKWATLLGEGKSVKRTNTVKRYVRKGIPSEHRPSVWMAISEAEQMKDQCPDLYQKILDGPFEKELVDLVKTDLPRTFPDNIYFTKEANHQTHLFNVLIAYAHNNRVVGYCQGLNYIAGLLLLATKSEETSFWLLKVLVEKILPDYYTKTMDGLIVDIEVLSELVKSKAPDVHQHVINLGLPWAVITTKWFVCLFAEVLPIETVLRIWDCLFYEGSKILFRVCITLIKNNRALILSCNDFTSLAECFKAIVKNASALHCHEFMQSIFKVPGTLSNSTIIKLRARFAKQRREQQQKEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8C6</accession>
    <name>A0A194R8C6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8C6"/>
    <dbReference type="InParanoid" id="A0A194R8C6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13495" checksum="48D50F827D24A1D0" modified="2016-10-05" version="1">MVVNIILLRVEASSQAITPIGYGSPTVYSQSDEDLGLLLTILMLAGRNKSGGTTCAERQASLLNDEYDDDDDEDDSNEELKKIVLKGDKGKYRDATGNGATIIQEIEVEQEAEGESDDAQIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8P1</accession>
    <name>A0A194R8P1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein RFX5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8P1"/>
    <dbReference type="KEGG" id="pmac:106712438"/>
    <dbReference type="InParanoid" id="A0A194R8P1"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="151"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1339" mass="146784" checksum="B1E0B32BDB82E763" modified="2016-10-05" version="1">MDHSTPFQPWASDDNPKNDNADRELVDDAKLHRENVNHPKHRQTASYDKESVVAPISIPGPSTIPGTDSAPGASKESMMDSSKISSMQQIVENTLSQEGRQRVTQLLEAVEALSGAERLLLYLRLPTGVPPHDPLKQPINPLGSRAELQQTVTWIQTHLEVDPDVSLPKQDVYDEYIAHCMSSNMKPLSTADFGKVMKQVYPSVRPRRLGTRGNSRYCYAGLRKKIKLEVPQLPVLGESSKESTVAPRETERIVCDWAESKLGVKFGSIGELSRHLVTVGTSQRAPPGPASASPPPLGHVPTEEPSGRQLIKQLKRKLQTQGTPGRPKKNKSQEISGESPPSTSYVSQHAPVKHESEMISEAGYAYQPPYMPVYDVRPPFPPYGAPPRAHPPHMTPSPHPMSVHEYRPDPYVFEPPYAPRDLTLPADTTHNLPINLSSDASLDLSTERTELQRRRPPEPPPARLPLPGKKLILETYQSETQAGSPRSSQIDTRSAHHVTEDFPRTEYLPKKMRAAEIMGGKLAAARQALSSAETSTSSVITETSARSEVGFLEDPKNLTSRSKSTAAALAREEQEAASPTRSLKALTPKCERPKLRKPYCRTKTSSPDKIDLPERTATPDSCCGLVEINIKTGMICEEKHSEILNRERVISICNIDKHDLDDYLNEGNSQEHEEELLQYFNHREADQEAPAQGNTNLNAPPFLGTSQDPQDEHSQGKNEKLSQLRELLAKNLKSQNGSQSVAINQDVHLPLETSQEMADKSNASVAEGAFKPVLGANVVDLMNGTTLSDPGEISSNNKHSNSNPNGNSSCAPLGSDAPNQLITNMASGTHLYNGSCHEPQSPTTRTQQYEFVPISDACHSPGNFHCKSPLGFNDRSHSPTKINKSVIMGGSLQTSPISHSTAASPFVSPRNTPVPRSRLCSRPTPKLNGRKRRNPLSLGMNDAGSKQFAVPNEQKFISKSTICNSIKYCQPMSAPPSPNIITQYKNQMLQNTPFMQNGTNHVCLNFVPNSLFRENINGDLAQPLSADPLSREVSQFFQEPVSYGLGLDTSYRSQSVPLKPGMNNIGLLSYNNTPVGSVPPTPVPNEFSDFGSLADTCDISKAGLNPETLDKIYDAIDSSNDVLNTGAAPNLLNANDALTNGCDTMPEQQILTDEQLNPFIPTGNELLDRNGQFNHSFGNEDAGTDNVEEFLKRTNSIELDLSDLVPDKSKYYTSRSVPSTPLPYKRTAPNLQIDSRRSRELFATDNYSNASNGISSKSVPSTPQLAEDRSVFSYSNRDFLINGNSVEVCGSTQIQNMVDNDQGLSSPLDMLREDILAPLTSSDLLADLDKMDGTPYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R983</accession>
    <name>A0A194R983_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeotic protein spalt-major</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08634</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R983">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R983"/>
    <dbReference type="InParanoid" id="A0A194R983"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002027">
        <property type="entry name" value="Blast:Sal-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000708">
        <property type="entry name" value="Sal-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000291">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="220"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="443"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="833"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="910"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1329"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="855"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1152"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1329"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1358"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ13820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1392" mass="152920" checksum="A9419F710BF17AFC" modified="2016-10-05" version="1">MRLRLSSGPGRNDRKDLKKKTFIRIRPHIHLCGESSGSCSEEEINNVLPEEARHQPEAHMCPRCQEQFENLHEFLYHKRLCDEKAIQMGEERMHSDPEEMVVSGDEEMDGPNKRLEQVRRHRQDAENNNSLDDGEAEVPEADVPPVGLPFPVAGHVTLEALQNTKVAVAQFAATAMANNADNEAALHELAVLQSTLFTLQHQQVFQLQLIRQLQNQLSLTRRKDEQRPSPLPHEPEPAAPAPPAPSPSPPRPPREPSPVPTPPTSQTLPSTHGHLTPRPEPITVPKLPTSSPPMMTHPPYSSISSSLASSIITNNDPPPSLNEPNTLEMLQKRAQEVLDNASQGLLANNLADELAFRKSGKMSPYDGKSGGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHTAKFPHVKMNPNPIPEHLDKYHPPLLAQLSPGPIPGMPPHPLQFPPGAPAPFPPSLPLYRPPHHDLLPPRPLGDKPLPPHPLFAMREEQDAPADLSKPSASSPPRAPDIFKSEPQDDDCQRESSYEDNDRVTPKREPEETDAGQDPEQDRYPSTSPYDDCSMDSKYSNEDQIGRESPHVKPDPDQPENLSSKNSPISGPISIATGLRTFPSFPLFPHSPPSSVSSGSITPFHNVPHGIVEPDLSRDPIFYNSLLPRPGSNDNSWESLIEITKTSETSKLQQLVDKIDNKVSDPNECIVCHRVLSCKSALQMHYRTHTGERPFRCKLCGRAFTTKGNLKTHMGVHRIKPPSQMLHQCPVCHKRFSDPTILHHHIRLHTSERGNIPYEQARTIDVNYFPQFSNSSDTAEFPSFRPFPPPLFPTPSTPGDRRADSRGTDDESGRDARAPSAREFDDDSDMKDRRTSPLSVCASASECEVKTITTTASLPSATGSESGRSARASPPSPSPSASPSSLSLSQSLCSPRAAQRSPPASPHDHLAHTAHPAHPTPLAALGALGGSPFSPLGLAFPPAVRGNTTCNICYKTFACNSALEIHYRSHTKERPFKCTVCDRGFSTKSSGGGCQCGRRARLPRPPHATALDLWNAFVYPGNMKQHMLTHKIRDMPPGFDKGGNGPAGPNEDTRDPSPDRRSSPDKMDLKRSPPAHPPPPMTHAPPIDMPPLPKRPTVSSTPTHPPSSASSKHLCGVCRKNFSSSSALQIHMRTHTGDKPFRCAVCQKAFTTKGNLKVHMGTHMWSGGASRRGRRMSLELPPRPLAEPHDLLRRPDLFYPYLHAPFLNGMQQKLNEISVIQQSAGQNGVAGKFPGLLGFGAFGGGRPGAASPLERPPSLEGGDERQAAMRELAERGRELAERSRQMRDDSDHYRSPGAHAPLQPPTAQPSPPAPHHPHPHPLASLPPPARTEGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA94</accession>
    <name>A0A194RA94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA94"/>
    <dbReference type="InParanoid" id="A0A194RA94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8894" checksum="D7176D75FD3D213B" modified="2016-10-05" version="1">MQISKFEQFINPRIMDGYSKIIITILNGSKFEGDQLPNFVRDSLKTVSETDEEDHDIEWNNRDEENDNIGDNDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAE5</accession>
    <name>A0A194RAE5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_13545</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAE5"/>
    <dbReference type="FunCoup" id="A0A194RAE5">
        <property type="interactions" value="2367"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAE5"/>
    <dbReference type="KEGG" id="pmac:106711444"/>
    <dbReference type="InParanoid" id="A0A194RAE5"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="66"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="457"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="497" mass="57207" checksum="4561B18528FB934C" modified="2016-10-05" version="1">MGKLDVAILRYLTSEDFRVLTAVEMGMKNHELIPGSLVASIANLRHGGVHKLMKELCKHRLLTYERGKHYDGYRLTNAGYDYLALKALTNRKVIASFGNQIGVGKESNIYTVADEDRNPLCLKLHRLGRTCFRNVKDKRDYHAHRNRASWLYLSRISATKEFAYMKALHERGFPVPRPIDFNRHCVVMDLVQGGPLTHVTSVPDPGRLYDELMDLIVRLGNCGVIHGDFNEFNIMLDEEGRPIIIDFPQMVSTNHPNAELYFDRDVKCVREFFKKRFGYETDTYPKFEDLERDDEMDTEIACSGYKRTRGVDDELLQEMGIGLQVSNDEDSQCDDEVTDEVNTKTNYEEDEVTALRNEVEKSIMNDERKTNVEEITSKTMSLRLENEQNDEEIPTLVPSEPKNDDTSSKIDTNSQKYRLAMIEKALSDVRSMRSYTSASTIAPEVVKQQVKKNLEDRQKKMERKKAIAKGEASAVTRQRRDNRDTIRESHGLWGWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAR2</accession>
    <name>A0A194RAR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAR2"/>
    <dbReference type="KEGG" id="pmac:106711174"/>
    <dbReference type="InParanoid" id="A0A194RAR2"/>
    <dbReference type="OrthoDB" id="7419010at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="571" mass="65455" checksum="AB7B4AB875DFFE60" modified="2016-10-05" version="1">MRITDLPVEIVVIIIKKLDIKSVHNLYESCSHFKNLICMYNVVKTANLALSTTATVHFLKQTFMKDISPHLQTLDLRGVGDLSRTALQSAVRGMKCLNTIDVSYTNINLFDIYEVYKLCPTIKNVACNFVFGTKKDIKAQNIQWQDLFQNFDKVHFVGNAANLLFSSLVAWMLHKACLSKLQLTIVENCGTVYDPVEEANDTNVKVHSKFISICILNVWKIPIFSETTLTLPSLQHLEEKYECVVVITEDLNQNQVYVSPMFMKVFKSYNAKCIKVLDVCKHVTNAVIMLWDKAKTVFDDMFFKVLKSKMINLLPHHITDNITVVPPEYDNCFLSVPLCDMRASSKNTVTFKKQRLAPQCPILNYDTVFQQHKTIHLTMFFPSNTNIPVTLSPSSQYLRKLRSLYLTGSVLYSKSFFYVLFSCCQQLETLNVEDSPWCPNQLGHIALSRLKNLRLVNRQSNFKAMFSSLSECSTLENIHILDSHMQQCNNLADPSALFEKCHNLYCISICVNISDSAIARANQLYKKLKAKYGKWHMHIALSSNFSQVSHNYDPYCHVFNLYPVKPLEQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBF1</accession>
    <name>A0A194RBF1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein timeless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBF1"/>
    <dbReference type="FunCoup" id="A0A194RBF1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBF1"/>
    <dbReference type="InParanoid" id="A0A194RBF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF5">
        <property type="entry name" value="PROTEIN TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless C-terminal" evidence="3">
        <location>
            <begin position="494"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="625" mass="71236" checksum="B40203F59E142D5A" modified="2016-10-05" version="1">MVQLIALLYKDQHVTTLHKLLNLWLDSSISESSEDNESNTSPQNRGSKNSSPNLTSNPTSDSSDAGGSGKSNDEANFLNNDWDASSRNNMNSSQPFQFPRSADNHVYNNNSGDSGDCCDGGDASDGVDNLKDTIKSDTPVSASDSNENYSENYQQRKSEKKVVISGNSDYGYVTQIENQESISTSSNEDELPTKKPFHQKPHTTKQRINNKVVTAIREFVQAIELYKKSPHTCDDDQDKLVSLQMKMCETDELRSLLVLLLRNFNPKYHPKQYLQDLIVTNHILLMFLDSIMKMPDYKGSTSMAEHIKQFATPEMMSQYGLLLEDYEGNGEFVNDCIFTMMHHVGGELGCYISLFQPKILKTFTSICQAEFEICDDWSDLIEYVINTFIKKPQSLQCIGTNQLESEKWTEDEISSLNWNYIQCNTTSDVIGEVLKLLKEDGIIKKRNSVIKELFKQSIINKEEFEKLLKYEMDRPPKAVEVNKEMRDDEIGKLCEQLAQDGKSKFLNWVQTVLLDTCYAKIYFEKKAQMDIDFTNKDKDMDNTKDPIASSVSYHSLVLKQSVPLVPWNCEQASICKDLKFLQLLHKLGFHMPVDSGKVFIRIPHFWTPDFIFDVASKISPIEKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBU1</accession>
    <name>A0A194RBU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBU1"/>
    <dbReference type="FunCoup" id="A0A194RBU1">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBU1"/>
    <dbReference type="KEGG" id="pmac:106710752"/>
    <dbReference type="InParanoid" id="A0A194RBU1"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14720" checksum="096A6B0A67EE0644" modified="2016-10-05" version="1">MVRMNVLSDALKSIHNAERRGKRQVLIRPCSKVIVKFLTVMMKHGYIGEFEIVDDHRAGKIVVNLTGRLNKCGVISPRFDVPINDIERWTNLLPSRQFGYLVLTTSGGIMDHEEARRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCG5</accession>
    <name>A0A194RCG5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCG5"/>
    <dbReference type="InParanoid" id="A0A194RCG5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265077" evidence="2">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="190" mass="20384" checksum="83019B1B2FE91F62" modified="2016-10-05" version="1">MKIKVVALLLLVLTTQCQGQFGSIGNFLSNTFNGINNKVKEVAGVIIGGISSTLKLNPHDDKKQPSDGTSVAPEITSVAPSSIAGDLNGQKNENKDDKVTENPVEVRPTFVPLDMSTTEEDFPIDVHSQNPNQKAAAEPPQRSASQKIADEQGSNNFNQNLNLNDNTGDVNLQSTGTANKQNYGNYTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF76</accession>
    <name>A0A194RF76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldehyde dehydrogenase family 1 member L2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF76"/>
    <dbReference type="STRING" id="76193.A0A194RF76"/>
    <dbReference type="InParanoid" id="A0A194RF76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="17806" checksum="FE1C0F9654470996" modified="2016-10-05" version="1">MPPVAVPNEAPKKQLRVAIIGQSTFAAEVFKLLQKDGHEVVGVFTVLDKGNREDPLATIATQYGKPVFKYKTWRVKGKVIPEVLEQYKSKGRQISRTSILAWPNEPPQSTFRHFERRNVTGGEPRRHLLLPGIHTYVLVTSRCFSSPYERRINVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFI9</accession>
    <name>A0A194RFI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TBC1 domain family member 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFI9"/>
    <dbReference type="FunCoup" id="A0A194RFI9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFI9"/>
    <dbReference type="InParanoid" id="A0A194RFI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="450" mass="50776" checksum="81B9E8BC7CAABC69" modified="2016-10-05" version="1">MEGIKEDAIHSTALKLAEEIKNLSIYKSFYSDIQKLVSSPNVKKEDFKQSLQEAMKQKGLDTKLRNTVYHWVRTQSKNNKLDPLTCLSKASSQWEKRIHKSLNSMCSDLETSLAKLRPQSEQDEFAEKWNELSTYSLDLSKYRPVYAPKDFLEVLLTLSGYVPFTREDEPKWEFAHLPLQVKNLDQLRKEYPEWASGEPLLGANPESRCEVGGGALGAERAALGARVSALRYAPVAQEFLKRGSPHCLRAGLWAQVLGVEITPHQTANFNQLKKSVLEVDLMIDKLIFKDVQLTASNDDQYFVFEDLLYQVMLCFSRDGEILQQLKGCVGSALTVTIKGKQTSPDNTTVFPPSGIIPFHGFSMYGEVRVVFKWLMRAFSGHLPPDQLLFLWDAILGYDSLDILPLLAVAILSFRKENIFQVNTIQNVDAVLADLSTISIVPLLQLALMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH27</accession>
    <name>A0A194RH27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein grainyhead</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH27"/>
    <dbReference type="InParanoid" id="A0A194RH27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="427" mass="48507" checksum="255871A2AD66E3D3" modified="2016-10-05" version="1">MCFHRFSPYGFKYHLETASSSSQRREDDRITYINKGQFYGITLEYVHDPDKPLKNQTVKSVVMLMFREEKSPEDEIKAWQFWHGRQHSVKQRILDADTKNSIGLAGCIEEVAHNAIAVYWNPLESAAKINIAVQCLSTDFSSQKGVKGLPLHIQIDTFEDPRDTQVYHRGYCQIKVFCDKGAERKTRDEERRAAKRKLSATNRKKLDEIYHPVTERSEFYSMADLSKPPVLFSPAEDIDKLAGMDIQGFYGHDEAALAEAHLKGASPFLLHAAKPQVPALKFHNHFPPDAPAYRSDVGGLSPYSDRKDSLELEGVLGKRARTGTPPLSERVMLYVRQDTDDVYTPLHVAPPTTQGLLHAIENKYKISSSAINNLYRKNKKGITAKIDDEMLAYYCNEDLFLLEVRPAGASEDEPLYDITFVELPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHI6</accession>
    <name>A0A194RHI6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHI6"/>
    <dbReference type="InParanoid" id="A0A194RHI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="7885" checksum="C3CF28ACD83FA739" modified="2016-10-05" version="1">MTFITILCHTWTGGTCPGAVCVLFGAKPSSAGRGRAAGEAEAPQVTLYRCHAAALRATALFEPTTPQFVTAVTMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHL4</accession>
    <name>A0A194RHL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase MARCH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHL4"/>
    <dbReference type="STRING" id="76193.A0A194RHL4"/>
    <dbReference type="InParanoid" id="A0A194RHL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF6">
        <property type="entry name" value="RING FINGER CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="22026" checksum="F78D883DEB6EB4C7" modified="2016-10-05" version="1">MRFLYYECHLRYTVTTSQPGAQGNQQLRSTGQQTDITCGYSSFASPVVVGEAESQRALRERLADSLTFAAPPSPPPARRSASILGSVCALLLRKQGSSGAGAIAGKEASVARSRQSGSICRICFGGASRERLARPCACRGTVAAVHRSCLERWLLQAATSHCELCRYHYVVTRTHKSLLASYRQTPRPERPRPPPHPLVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI65</accession>
    <name>A0A194RI65_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI65"/>
    <dbReference type="InParanoid" id="A0A194RI65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="189" mass="19764" checksum="7BF4A9744D908E12" modified="2016-10-05" version="1">MGQTATVEAAENNEETRIHVNPTEQSLTESETSCEEAARLTAEGAGEADDDEAFDYGALPPPPDGGYGWVVVFASFMCNLVVDGIAYTFGIFLPELVTYFGEGKGTVAWVGSLLSGVYLAAGPIVSALCNKYGCRAVCVAGSLIATVAFALSTLSKSVTMMMITYGVLGVETTDSFTGPPADMFLTNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI66</accession>
    <name>A0A194RI66_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bromodomain adjacent to zinc finger domain protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_13876</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI66"/>
    <dbReference type="FunCoup" id="A0A194RI66">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RI66"/>
    <dbReference type="InParanoid" id="A0A194RI66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000300">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="17">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="16">
        <location>
            <begin position="369"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1014"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1253"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1275" mass="144974" checksum="8360843600137BDB" modified="2016-10-05" version="1">MPLLKRKAFEKSTVSEYLRDDDEVFHCEITDEIFKDYEEYCERIILVNSMVWTCEMTGKNNLTYAEAMESEKAARKSLKDFPMELRIPILYLAAKTKRCSFAEMSEDVFNFVRERYFVGESVEACLEGDQWREAHILSVTVQKQHPNSTSTPPASSYCYEVEQFQESEQTSAGQMGTAPYDRVRRRKGVYSRDKNRLFLKQFVEQGIGGIITIKQSAMDKYNINKVNFNQIFTGSPPEFASSKKLLKTSMSPPKAKPGSATKLNKSLKKVSPDKKGRQESMDKFVKKTDKSEASPKPKQPMDPEARKNAQELAEKMRRAEDQLRQRKEEEKAKKIAHLKEWKRIKDDQELEDHKVIPQATPVQVEGIPHKHFGDFLSILEFVHMYSDILKVKDVFHQDFDLELFRKSLTLKEHAGAFSDLVQMFLTTIFTLQEDEAEEYNENGSMQELYMLASGGVSGGRNAALRSVQRGGYTGADDAALRLRITKPAVVRRLASVHVADLPLEDKFLILQCLMNQVLSYATVRDVTEERLEEYKTIKQSLRMLQINERKREVQLVATRQELKKEAQATKTEQKLSGDQAKEIDEQLKISIEKLNKKSDVKKHEYEKKLKELQLSLFKYTSYVGMDRAYRRYWVMRRVGGLFVEAGDEERGLCRHKLTSPHLMREERAGSDKENESAANLRGSPKKPYVNGVGVKVVGAEGGAPTSAHALQRARELMLCTADVNTCFVHGKVDRPHWSVYHTEEQIVALLASLNKRGLRENELRHSLEQDGAHLLTHVASCPLHLLNPTVAPPPVQTSQHMTRRRWQPSLSVPADTSLSEALELSLRDHILELEEKIFHGCLGALKVKAWRGTLMLKGYDKQAEYLSWGPGQKYRDDYHQPNGVLKLPNDVDKEELEAIPINRYRDPGHYLDAPKMNGIKNGYEETREPSAEVVRGLACALLQVSQAIHHKYLKRPLGLDDKERKDREAKNKSLDLEALERWEVSLMECRSFAQVVLHLLTLDSSITWSASILNASCRICRRKTDPDNMLLCDGCNKGHHLYCLKPKLSKVPDGDWFCDQCRPREKTPRRKRKLFSDDDLEDDLDNSVGVAEGDVGVAEGDVGGANLEWGSVCGACGSGGRLAASCRACGARCHAECVSQRRALCNTCTSNGSRREHTVRRCAATAINNIHEYARVLDAPLDTSDSEDSEYNTALVKLKKRKSRSSKDESPVPNGAKRGRKAGYRLEKYIIKRCIELDLPPLSPTVLDDEVEEPIKRKYQDDIDEDPKMKRAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIL2</accession>
    <name>A0A194RIL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIL2"/>
    <dbReference type="InParanoid" id="A0A194RIL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="238" mass="25757" checksum="770F03E83BEADD28" modified="2016-10-05" version="1">MAGRTVRKVKRGRAKESANYLTQLPAIIVTPPDCGGDMKIKALEKSGEVRNVNNASLNENLLDTCKQTKFNAMTEFSVRQLIANLSENSRASKNEIENIQRRLLQQANEIMKVNTFAKSQAIAEPRVIASTQKHGSAVYGRIPVAPRNAVINGTPNSAGAEQPNHSDTQLVPERLQETRTDNVTGGMNSDRGNMQRVGAATATADAGRIFFYETSSAARAATSARPATVRGECLTICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJK7</accession>
    <name>A0A194RJK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aryl hydrocarbon receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194RJK7">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJK7"/>
    <dbReference type="InParanoid" id="A0A194RJK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000069">
        <property type="entry name" value="Aryl hydrocarbon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF12">
        <property type="entry name" value="SPINELESS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="521" mass="59112" checksum="D068CE623830E52D" modified="2016-10-05" version="1">MHKEKEEMHAHRRDHVHYDHAMPDGEMFLQALNGFLMILTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLWNSFLSPESSNLTLQDVLRPERTHLLERSFTRLDIRGRIKVLHGQNKKTEEPPLALFAICAPFGPPSLLEIPQKEVMFKSKHKLDLCLVSMDQRGKMLLGYTDAELANMGGYDLVHYDDLAYVASAHQELLKTGASGMIAYRFQTKDGQWQWLQTSSRLVYKNSKPDFVISTHRPLMEEEGRDLLGKRTMDFKVSYLDTGLTSLYFSETEQLSGCESTVTTPPRAARRYKTQLRDFLSTCRNKRRVPSTPAPPPVDYLAADAVAAAYTNLNGAYTGPYGEYPPAPALHYAPPPLDDRFLAADNLFHQYKPLPYHYTPYAPNGFLEPAPPPGYEVAPTYHRPPSREYTYVDSTGRYMSPVTGQERRSPSVVPGPSPGGSSGSTEQERLQQTQPSEMPRQTVLMWGAGGTAQEVPVEYSPPQVWRYHQSHYHTAEATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJV0</accession>
    <name>A0A194RJV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJV0"/>
    <dbReference type="STRING" id="76193.A0A194RJV0"/>
    <dbReference type="KEGG" id="pmac:106707819"/>
    <dbReference type="InParanoid" id="A0A194RJV0"/>
    <dbReference type="OrthoDB" id="5980806at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF60">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="728" mass="82887" checksum="5763696686877F0A" modified="2016-10-05" version="1">MEEIEGDYVNYARQLSSSGNLSKSFDIYISVFEKNPRLKNMYEPEFQIVMMRYNETLSAAGKIEDIFTNFSRAIKIFPKNVYLLNEIGKYLYKFGYYEEAWSHFQKALSANSGFVNAEKNLNSVKNLLVERWHFRMLNDKKRNELFRAAIHEIVKFGKDNVIDVGTGTGLLALFARECQPLTITACDGSSVMTKIAENIIQDYEINDIAIVNKMSTAMDYKEIGSKCTVLVTEMFDAGLFGEHVLQTLLHAWNYLIDVGGKVIPGRAEFFVAGVNCNYLNLKYQLGQGIKTLLNIPTANVHMMSNDETYDCEDVHSFKDLKYMTEEHSLIKIDFNNYDDIQDKLYRSEPFNIDLIATQDGEINCMIGWFNLYLTDNVTITTDPRSEDRCNAWQQAVFFDIIPKEVKKNDSYTTQFLMNTGKLTMVPNYNINIDKISHEALRFLNDSEYVKTILGCVGMACVYLGQIIEMAEIVVIDLCPFPLFGLQMLKRGAKSLVCTARTYNDEIFILKVLEANKIDISKITILVGDLWNLDSFVDTLFHAIFCHPFELCGEIDLRLKDIAHELKTSHLAPGGLYMPATISIIGQLVDSHWLDINNRVYDENTIDYKVSGYMNVYQVSQNFCIDMSRLEYTPMSRPTCLGECSNELRSFVINVPIIKDGTANAILCWYKIELMEDIGEIATNRSDGFVDSIAFLADPKVPMKKGDIANVLRCVDPDGGFKLLVDIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKE3</accession>
    <name>A0A194RKE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periodic tryptophan protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKE3"/>
    <dbReference type="FunCoup" id="A0A194RKE3">
        <property type="interactions" value="1992"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKE3"/>
    <dbReference type="InParanoid" id="A0A194RKE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="42368" checksum="ACE81D2B14A7EADC" modified="2016-10-05" version="1">MEENTPTVSLVSCMHFVQRGVAKSVPEKIELTEKELEKIIKQTADDLRITEQGDDQSDEEGETETREPPANPNDEFNFDQYDEEDSITVNPIGIGTVATLPNLGDLSENVQIRTEGPDSDEEDDIIKPTDNLLLVGHVESDASILEVHIFNKEEGSFYVHHDIILPWFPLCIEWLSHDPTDPQPGNLCALGGMDPVIQVWDLDIENCLEPAFKLGKKPNKKKKIKRVGHKDAVLDLSWNKNFTHVLASGSADKTVLLWDLDQGTPHTKINYFSDKRSTALLYKHYNASGRQTMELRFDLGRFRAFTPFEGATQVSMRSNKSGQSLCVAACPDAPLSLALGGDNKQCHIELVDLTANEQGEDHTLLKPAHYTFPILSQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKH8</accession>
    <name>A0A194RKH8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKH8"/>
    <dbReference type="InParanoid" id="A0A194RKH8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="42" mass="4804" checksum="40CF457AE96410E4" modified="2016-10-05" version="1">MGDEKRTFLDLCDLLEYACDTNQVYSHVDDMPGCPVSKNNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKS0</accession>
    <name>A0A194RKS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKS0"/>
    <dbReference type="FunCoup" id="A0A194RKS0">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKS0"/>
    <dbReference type="InParanoid" id="A0A194RKS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF31">
        <property type="entry name" value="LD31969P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ankyrin repeat" evidence="7">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="7">
        <location>
            <begin position="96"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="484" mass="54431" checksum="632EE2AD5A771F54" modified="2016-10-05" version="1">MSHRRSSFLWFMVCEQLDAHEPAAHHSPPRRALLQRLAAPLALNYLDTDKISFERNKSGIWGWRQDKTETVNGYECKVFSANNVELVSKTRSEHVNGGIRTQDLQITSQENKSGIWGWRQDKTETVNGYECKVFSANNVELVSKTRSEHVPRGERARATPRAPLAGLLALADREGASPLLTPEQEEVDEEPHTSRSSEDVKPVTWCEYFSEMPLERDIGRPKEMTTKVQKFKATLWLCEDYPLELQEQIMPILDLMTAISSPHFAKLKDFIQMQLPAGFPVKIEIPLFHVVNARITFGNIFATESPVPNIECIQEGERLSCIVDDACFEIGRGYRDTAASDDRMSNGTDDDEGLLQYAIQQSLMEAGTHDDQVDVWEALRGARPSSPAPPRALLAAEERQLQRAIEASLSLLSPEERAEADEMLAAALEAEVEVGEGGEVEVDAEAELRAALELSAREHAELDRRRQDEERALDEVLRLSLIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL87</accession>
    <name>A0A194RL87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta and Notch-like epidermal growth factor-related receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL87"/>
    <dbReference type="STRING" id="76193.A0A194RL87"/>
    <dbReference type="InParanoid" id="A0A194RL87"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000404">
        <property type="entry name" value="Weary, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="545" mass="57895" checksum="6CC3839A4CB9A6A2" modified="2016-10-05" version="1">MSEECGAGSPGGGGGEEGCPPVVVSWEGTADIQSGDILIVRIADPLLLDSAPHVANNNDTEDSNSIDAAQRAHRASVQPAVYQVTRQGHLHCDVTDGMLLDITPLDENDAKLFTLYDKDLTEGVNLLIVVAENWGSQCVRLKVTVKSDNCGESQECSGNGVCYTNVSMEGYECQCCRGHAGPHCEERAACSPSPCLNNGICVDLTQPLNGASYHCLCPYGFTGRKCEKDPCYSAPCSNGGSCMSMAVNGSTTFHCACSSGWSGPQCEQPVSKACTAKPCAHGICVEEKQANNGKNYRCFCEPGYTGEHCEVEYNECESSPCLNGGTCTDRVAGFTCACGRGYAGNACQLKVNLCSPNPCSENHYCVDRGNSYTCECIDCNIPPRSPCDNNPCAHGGTCWSSSNSFYCSCQDFILEPVVEGEVGEMGVGEAGMRSEGRAGGVRELRLPLGLYHDRLHNVYIAAGTLGAAIAIVGVVVTACHCRVNKTYARLLSRLSRVTEGGPPHHWLQEKRGSAPPAAPPAAPLDTADMYYTLDFSDSQSSPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMD3</accession>
    <name>A0A194RMD3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ribonuclease ZC3H12C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_10631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMD3"/>
    <dbReference type="FunCoup" id="A0A194RMD3">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMD3"/>
    <dbReference type="InParanoid" id="A0A194RMD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ18687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="527" mass="58164" checksum="9252332EA91F53DA" modified="2016-10-05" version="1">MNCFLKKKKHLVIVLFCYQKYVESSLGWSGERGEDSSYDSECDDDGGHRTASRTPSDTLAAEFAEYVTLAPPPQPNQAKIDFAVKLGYSERLARTALQRLGPDPPRNELLGELIKLAAQRPARPLSPPAPAEPEPSAERAPLRHVVIDGSNVAMSHGNKEVFSCRGIEICVDWFRARGHKEITVFVPKWRKEASRPDNPVADRDALDRLERERVLVYTPSRHLGGKRLICYDDRYILRLAAETDGIVVSNDNYRDLATESPDFRKVVEERLLMFSFVNDRFMPPDDPLGRSGPTLDAFLRAPPSKTDPPPACPYGRKCTYGNKCKFHHPERAGRPHKPVAEKLSERAAKAMKARDLHTLSLPPSGRPADNKRPLARAHSAAPRVPDATLATHFDRAQVVPGPSQPPQETHPNHSNPHRKLARQLIKSAWHAAAGRVASAPVGAAGAGVAAGAAGSAMSLSPCASEGALQQWEARRRMHFHLAGIFPEAHVAEAMATFPEETDAQKMCAIILDRYRPSEAPLPRLSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ24</accession>
    <name>A0A194RQ24_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ24"/>
    <dbReference type="FunCoup" id="A0A194RQ24">
        <property type="interactions" value="2419"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQ24"/>
    <dbReference type="KEGG" id="pmac:106718095"/>
    <dbReference type="InParanoid" id="A0A194RQ24"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="352"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="449" mass="50103" checksum="124C28F4B2E23234" modified="2016-10-05" version="1">MATTETHVPEQQRRWHNIRKLLERSGPFCHPDFEPSPDILDFLMESCKILVVGAGGLGCELLKDLALMGFKKNHIVDMDTIELSNLNRQFLFRKSDIGSSKAKCAVDFVNKRVPGCEAVAHHCAIQDLDEGFYRQFHIIVCGLDSIVARRWLNGMLMNLLQYNDDRSLDQSSVIPLVDGGTEGFKGNARVILPGLSACIECTLDLYPPQKTFPLCTIANTPRLPEHCIEYVKVIQWPKENPWGSSTPLDGDDPQHVGWVFEKAQERAMKHGITSVTYRLTQGVLKNIIPAVASTNAAIAATCATEVFKLASSCCTNMNNYMVLNMADGVYTYTFNAERKPDCVACSNTTRVLDVEPGAILMDIYEKLKEDTGFLMKNPGITTVINGRNKTLYMPSIKSIEERTRDNLKKKITDLGLYNGGEILVADITTPNTISIKLKFIENTDVEMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSG2</accession>
    <name>A0A194RSG2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSG2"/>
    <dbReference type="InParanoid" id="A0A194RSG2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="16083" checksum="38619E9572125E71" modified="2016-10-05" version="1">MHCTYSYTHFNGKPGALALRSNETTVSFAGTFRTGVGRGRGLAGEPRPAVAPPSDCSSPFYEWKAAILNESRTRSGRPLFSQASDGVRRGGGRGPEAGASAGGAKFCGAGGGGCARLSSFRRALSACAPRPSSRPHPGIRFPVGESRTIPPTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RUG9</accession>
    <name>A0A194RUG9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-beta-hydroxybutyrate dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RUG9"/>
    <dbReference type="FunCoup" id="A0A194RUG9">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RUG9"/>
    <dbReference type="KEGG" id="pmac:106714327"/>
    <dbReference type="InParanoid" id="A0A194RUG9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="389" mass="42749" checksum="D3563C3465B82864" modified="2016-10-05" version="1">MAAGDVTRRASITAPSMHRRPSARRGSLIKNPQTQSQEVPWDIIDRCALPIVLCHALAVVLSALLNAMHISQISVFTLFLWFSISVTGSLWFYHNLQVTAAGKAVLVTGCDNVLGNALARRLDDLGYHVFAGFQNKAGNIDADMLKEDCSGRLHTLQLDITSETQILSASLYIVDHLPEGAQGLWAIVNCESWCALGELEWVPFSVIRRAMEVNLLGPARLVQVMLPLVRRARGRVVLASSILTHVAAPVRGVHAASMAALDALAACLRRELKPRGVDVVVVAAGEYTTGSAWLSEEKLLEQARDMWKRLSDEQKGAYGEDYFEQALRSLEKYTKSADGDLTAVTRSLSDGVTRTFPLARYTPVSPREKLKSLLAEHLPRSLYEGLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB95</accession>
    <name>A0A0N0PB95_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0459 protein CG10681</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB95"/>
    <dbReference type="FunCoup" id="A0A0N0PB95">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB95"/>
    <dbReference type="KEGG" id="pmac:106716431"/>
    <dbReference type="InParanoid" id="A0A0N0PB95"/>
    <dbReference type="OrthoDB" id="10258877at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="3">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24837" checksum="3E8543161F8748B3" modified="2015-12-09" version="1">MANDTPESDFSIECFQNYTAPEVFVQGLAGMVDQTDVETIIRAQKVMLQRFEKTTEMLTNCNQLSSSRLRAASTEFKKHTQLLLDMKKDLEFIFKKIRAMKTKLSQQHPEAYKQAVAASIANRKPVNEDEDNDFGVSETRVQSKMVATVSTETLKPTTSNEKKSKKKDIKLNQENNNTEPQSSKDIIDSPTFLMMGKRVKRGSSSSETESASSGDDTSTDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCT4</accession>
    <name>A0A0N0PCT4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoplasmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460557">
        <property type="protein sequence ID" value="KPJ13972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCT4"/>
    <dbReference type="STRING" id="76193.A0A0N0PCT4"/>
    <dbReference type="InParanoid" id="A0A0N0PCT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857350" evidence="6">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="25254" checksum="4BA837660FCF3498" modified="2015-12-09" version="1">MKYILVLSLGLLLLGWSQAQEEGGGADQPTADVDLGASREGSRTDAEAVAREEEAISPDGLSVAQLRELRERAQNFTFQTEVNRMMKLIINSLYRNKEIFLRELISNGSDALDKIRLLSLTERDVLDSNPDLSIRIKAEPDKRLLHITDSGVGMTRHELVNNLGTIAKSGTADFLSRMQDSEKGFKCETVTCNNIFCTNVPVPGADWCHTFDHTEDTRQAEFIPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCY3</accession>
    <name>A0A0N0PCY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphate carrier protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_00832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460512">
        <property type="protein sequence ID" value="KPJ14162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCY3"/>
    <dbReference type="STRING" id="76193.A0A0N0PCY3"/>
    <dbReference type="InParanoid" id="A0A0N0PCY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="17430" checksum="4924B2C600A54DD5" modified="2015-12-09" version="1">MCEVNPHWASVVDFSITHTAVVPLDLVKCRLQVDPDKYKNVLTGFKVSVREEGMRGLAKGWAPTFIGYSLQGLCKFGLYEVFKVTYSGMLDEETAYTYRTFVYLAASASAEFFADIALSPLEAAKGSCGVVGLFSDFTRSLCPMGCVFESHHCRRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD69</accession>
    <name>A0A0N0PD69_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460345">
        <property type="protein sequence ID" value="KPJ15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD69"/>
    <dbReference type="FunCoup" id="A0A0N0PD69">
        <property type="interactions" value="1672"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD69"/>
    <dbReference type="InParanoid" id="A0A0N0PD69"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="13724" checksum="B571C82327E0EE88" modified="2015-12-09" version="1">MKQVEDAKSFAIQSFCKDLLDVADTLSAAADSVPERAEAHAESAAAALRSLHDGLRLTRAQLDQVFARHGLVAVSPLREKFDPNLHEALFTQEVEGFEPGTVVTVSKVGYKLHERCVRPALVGVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDA6</accession>
    <name>A0A0N0PDA6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N0PDA6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDA6"/>
    <dbReference type="InParanoid" id="A0A0N0PDA6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644">
        <property type="entry name" value="AGAP008221-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1913"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="2002"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="2131"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2234" mass="250193" checksum="1D302FEA1B547CC9" modified="2015-12-09" version="1">MHLHLRLSMGNGRLAISANSDDRLPVCHRGASGLGVSVSTQADIAHSAKGYESEDENAGRKRQRASDDRPPSKTNMYSKQEFREQYCINNKQLDLLELEKSKKDRFLGCLSQYHIESPCSRANRASFLSVCVRRRVPSDENLNTDYAPIQRYPSFGQPSPAPAELCAHDSELECSYFRRRPRSVCSQPDPKRYTWMPEDEDFTRMEWPQSVIEDNAGWPQNYNVDQIASVSRGGSLPRPPTMIPCPAHTPIPPPPPPPPLTIPPHRTKHVSFARSHTLTTFDDSVMPAAVSGGRYRRDCERLIDGRTVKPESKPYAALPVIFQPFAPYPQYIAAQNAPAMHYPPPMGPMPTHPIVPPQRPQQEQPKVVVLDSIKKGVMRTQATQTEVCLGRKPLPPNYLSLSPRTIKRVKMVAAGVQTNGYTVGVRRLTKSFSEVGGDRLLGRETQNEINATLESFINHDHEKLHRTQSEEPPRSPRSPTSVTPSSPLLQRGDSDDVTSASIKSVASSQVDKSSELSALQRQAQEYFQQNFQFIHESDRDDTIDDDIDNIEKSMALNRRNLEYLQQEIAKQTKAERSLKSILSKSTSDASQKTMTTSHPLSKTSTFQSEPSTETSATTTDDSEKNEKEIIIDFEPRPDDEAIPFTTLRRKNKRMLQKTMSEGEILLDVRKNEINSSSEGIKDAPIIMSTSQENMTREDRERDAMYKQYIGQNYNQTPIKDEGIFAFEPDGSFSSSDGNAPYEDFHEKYISYKHEPFRIRSVSFEEQTDTIIRDEMPSPSTAKSSPGSPDPVHIDNELEQKTKRAVITNKVTTILAPLESTSPCASNESLTIDHSRDHSDGLWNESQTTVLQVDSGTDNGTVISSSDLSSLAASPGALALLTPTSRRKQLLLLQHQQRSSLDTDALDEEFDASQSQSPTSPRTKLDACSINSTQQMRVSLSPPAVVPNVMLPITKQPMLSKTPSPTGLPKPSHTPAIAITHPSLDLSDIPFKRTPSFINKKRERALSPSRRRDLQKKAQQKEPNGSIPKQIMESPSEPILTKTGSSETSLARTDSGRLNTTDLSESTTTTEDYVTANSDSSKKSNSKNQNSHPENNKTQEGSSFESASSLYSSTKTDNVAEDLIVPSFSPPLQISDDFIVPDLSSPPLTLTDKISKPSVERFEVKADINHTAPPIRREKTEIIKSKEELSKASTTTRGTVSGKSSSSGSYSIGGSNPNVTESVENKIANEKSKKLHDVTETKEVLKPKEDQKNKQDQREQLVPKMTGSLSDDERSAHYSSSGYYESPVEDEDDGGLTYKHSQKYRSNNRQKSWLTDDKKRKKRAFTLEFSKSCDDSISTSQDDWVRKDKDIEFNSRSERNAHKPPISKSPLEEKGLEFRKKKTQFVEKNKTLQSSPKEPIDIDKGLKEKTMKDKETESRRPVERERYVKRTKLKAKSPTQNKNIDGIHGHRPQHYDRREGLGSNMKLHLNIPTSDDSSEQYRKDRIGNGNISPRKHRRLRDSPRRKNGPNSILAKSPTSGNSHVYRPRRKSGSNESISLPGSLPRRKQSITTIPCVSSLEAEDIETTRTLANAGSRLTPLRYVKSPTTSPRHHRKQDKEGKFAKAASAESLRSVSPGSDSVFYSEQTEHSVVAADGEAKAHCLHCGKEVHIVTATHDHDSRASRTSHTDESYADATPDIVPAPAGFADSPSCVPSKKPASGARLYKKLDKRYRSEDKSRHHYRHRQDVRAKSEERGKEEYASTEKPQDTRIARSAGNSLDKLGGSNASVDPDEHEECSGSSEGAENSREEKGVYAAPWWCGNWIMLSENDDHWTRIPPDLIDTTDSCHEDPTESEVEFNKRYVALTHRLVHRRACIELNKRQADNSFVRDMLASSSGSLRQKLEEIFKLMLVLWCRQTQINKLVAAETCESDKTVVVRRGNEEFGFRIHGSKPVVVSAIEPDTPAETSGLEVGDIVIAVNGINVLVKTHSEVVKIAHSGSEILELEVARTCDVVASLAHEGGAALYSGYLWRAAPRPHQPHQPAPPPRWTRRWFVLKRDNCLYYYKTDSSIHPVGALMLVNYQLTEEDAGRPFGFRLQRGGGARLQLAADTAEASARWRAVLAHAIDASNQRDGWLEVTMRNMKLPPSSILRPDCFGYLMKLGSKWKSWAKRYCVLKDACLYFYNDGNSKSAFGMACLHGYRVQSCATGGKKYAFEVMPTETKQRHFYFHTESEMDRKRWMAALEYSIDRWMKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDD0</accession>
    <name>A0A0N0PDD0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460234">
        <property type="protein sequence ID" value="KPJ16411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDD0"/>
    <dbReference type="FunCoup" id="A0A0N0PDD0">
        <property type="interactions" value="1189"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDD0"/>
    <dbReference type="KEGG" id="pmac:106709350"/>
    <dbReference type="InParanoid" id="A0A0N0PDD0"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="932" mass="107123" checksum="CB16DBA37C0E7931" modified="2015-12-09" version="1">MSQPNLLDIVPEELFQTHSITEIDHVQKKLQYEIERKREELRAMVGERYRDLIQAADTIEEMKLTTSSTLDHINQMMISCKSLHDTHLVGFKVQEQPQKPSFQLNSNPAQVIAIQVKLLMEIPEKIWKCIEKDDFVKASQLFIMARHINTGLQLHIGGRNVKPSMQSLQRIVQQHWISISNFSQTIINECRKKLQDVEISVSVASSCLVSLYLLDSQTMVELLNTLIGLHSDSSLRSTLQFDLTHILDGDVKAQIKKKIINGVKIVLKTVVLVYACFVDNDGGAVLDMLKDLYKKDSKPLLDLIEFSDTASLKLLPSVISNYKLSTQKKVCAVAKQDISKSVQQWSVWVKTYIESNVQVLLENVTRIKILHEIREESFKIETPSNWSAICTALDIPEVHVWCHYFQPLLTSRVKLIIDNRWIKVYDGFKTQMLVDLTKVSSESELEKEFDINWFVWKDLIGETIIESRNDVIRVMNSLMKGMSRQDRGFTPNIEKLCKGLDEELQKLLEDLKVYLYPEKRSRSNKLLFYEEEDDRQQIYSDREDIQNYLRNVSDRNVQSMLQYIKACFEESTLQTTELQRKTTAVYTARFIQAIVYLIPNLRKCYIPEEQCIDDMNVDENSIKSWNDICVVLKDNCQYCWDKWLDIVMEKVIDLIKCLPQQFTLEANVDYLMMQWDVIQIQEKDDEGNSIESTIKVPAGPSLKLQEYLYSVSRILDEVVPHTLPHEVHTTFVEKVTSVLLAHYNTVIREKESDINQRCALQLLMDVRHLTMLMVPRENKKCMESSQDICEFLRQKIDPFDYDVFYPYIQTNLKRSVQRVQTLLGSLVLHHGQLSGILGNRPVVSGGSGDKAAQLLASADAHWFTLLPVATPTPHKKQDKVVKKKAVPAASPNKNKADISDLMTSSLPINFANARSGAASFFTSMTSDWFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDG7</accession>
    <name>A0A0N0PDG7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDG7"/>
    <dbReference type="SMR" id="A0A0N0PDG7"/>
    <dbReference type="FunCoup" id="A0A0N0PDG7">
        <property type="interactions" value="1690"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDG7"/>
    <dbReference type="KEGG" id="pmac:106709130"/>
    <dbReference type="InParanoid" id="A0A0N0PDG7"/>
    <dbReference type="OMA" id="ADLHTWH"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23801">
        <property type="entry name" value="UBCc_UBE2L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000011">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17797" checksum="1D97EA26D0E73C40" modified="2015-12-09" version="1">MAATRRLQKELNDIRQSGLKSFRDIQVDESNILTWQGLIVPDNPPYNKGAFRIEINFPAEYPFKPPKISFKTKIYHPNIDEKGQVCLPIISAENWKPATKTDQVIQALVALVNDPEPEHPLRAELAEEFLKDRKKFTKNAEEFTKKHSEKRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEG0</accession>
    <name>A0A0N0PEG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA cytidine acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05808</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEG0"/>
    <dbReference type="FunCoup" id="A0A0N0PEG0">
        <property type="interactions" value="1571"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEG0"/>
    <dbReference type="InParanoid" id="A0A0N0PEG0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="10">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="13">
        <location>
            <begin position="630"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="88464" checksum="6AC3FC49AACEB7C9" modified="2015-12-09" version="1">MVKKKIDNRIRVMIENGVKLGHRTMFLLVGDKSRDQVPILYDMLVKSTVKSRPTVLWCYKNKDEAISNHGRKRAKKIAAGKLEVSEESLFDAFRVATTIHGRYYSESHAMLGQTYGVCVLQDFEALTPNLMARTIETVEGGGLIIFLLKTMDSLRQLHSITMDVHSRFKTEAHDTVVNRFNERFLLSLADNPRCLVLDDSLTVLPISSKTAQVEPVDVLPEKVNPKLTDLISSLSDSPPAGPLVALCRTYDQATALVALINTLADKQSRPPHCLTAARGRGKSACLGLAVAAAVALGYVNIYVTSPHPENLITLFEFVLKGLDACLYQEHIDYNIVRSTNPDFKKAIVRINIARNSRQTVQNVNYRTVRDSLGRGRKAAGDLIPWNICEQYGDKDFPKLSGARIVRIATHPSYQRMGYGKRALQQLAAYYSGDIPCLDETASDDEDKTNGQTDTLHTESIVPRTKPPTLLKRLTEMGYGKRALQQLAAYYSGDIPCLDETASDDEDKTNGQTDTLHTESIVPRTKPPTLLKRLTEVSPEHLDYLGTSFGLTESLLKFWKSQKYVPVYLSQKANELTGEHSCIMLRAMSEGTWLSEYSADFRRRFCRLLPRALRKLSASLALTTLLNDHVTVIFVAMGFQMKDVDDIASELGLPGSQILAKFYEACKKINATVNSVLEDTVAKEIGIDEKTADLNTEGPVKQSLNDELSKAAKELERKQRKELSRLMGEDLAQYRIRGSDLDWNNALATNKQKNIISVKSGEKRLGDDSKEIDDLIESHSNKKKKKKKHVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEP6</accession>
    <name>A0A0N0PEP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459747">
        <property type="protein sequence ID" value="KPJ20206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEP6"/>
    <dbReference type="InParanoid" id="A0A0N0PEP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857270" description="Secreted protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16732" checksum="0E2361157A67D8BA" modified="2015-12-09" version="1">MIALRPANVLRLLLGSSTVSYLLFGSDTTHASTCTNTATPVRPDHQPLARTLTVQVTSQCARPMCSTYSSAVAPCPTSSSAVTPRTLPRAPPIRLLQYRDTDDNPRAATACAHAAAAPHVLLSAPPATTLATNDDDNSQLMSGRESSPQHNNHYHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEW0</accession>
    <name>A0A0N0PEW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi-associated plant pathogenesis-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEW0"/>
    <dbReference type="FunCoup" id="A0A0N0PEW0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEW0"/>
    <dbReference type="KEGG" id="pmac:106711771"/>
    <dbReference type="InParanoid" id="A0A0N0PEW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="178" mass="20392" checksum="C9F75C8720CDBB99" modified="2015-12-09" version="1">MVVQWSEVRTAWQDSDFITECLCWHNVYRQRHGAPQLYMAPELCDYAQAWANHLAHTNKFHYRNDRDVGQNLYQRPVSNLQPDVTGQEVSSYWYAAVRQYNFFKESDVLHANVNAGHFTQMVWVATRFFGVGKARSRAGKVIVVANYSPPGNMSGQFETNVLPPLPDNLPELAPPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEZ8</accession>
    <name>A0A0N0PEZ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein not2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEZ8"/>
    <dbReference type="STRING" id="76193.A0A0N0PEZ8"/>
    <dbReference type="InParanoid" id="A0A0N0PEZ8"/>
    <dbReference type="OMA" id="EDKFNAD"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000450">
        <property type="entry name" value="Homeobox protein notochord"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="253" mass="28864" checksum="7383C2CCEF49516A" modified="2015-12-09" version="1">MDQRQNIYPTNITDLLYQQSITRLTALGDGEVKYNTDTYTDNVDNADGSSSPSTIEDADSESTFGVDLSGKGTNLAGKSFTIAAILGLSNAEEDAMNLSVQERLHQNQRQLQNYLYAGHDMQRLNDGFCRSMVGVPQALAQDSPRPELRQQVGQMKSSRPHAITCSTGNGRSKRIRTIFTPEQLERLEAEFERQQYMVGPERLYLAHALQLTEAQVKVWFQNRRIKWRKHHLEVTQQRLAVLQRHRPDERDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF47</accession>
    <name>A0A0N0PF47_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459692">
        <property type="protein sequence ID" value="KPJ20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF47"/>
    <dbReference type="InParanoid" id="A0A0N0PF47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="60" mass="6491" checksum="A31F18D4E27F453C" modified="2015-12-09" version="1">MSRPYRSPVTGLLPGSIRSGRAAPPLSIARGAEGRARLYVICYPRMRTVFHSVGCVCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF52</accession>
    <name>A0A0N0PF52_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes juvenile hormone hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="6"/>
    <dbReference type="EMBL" id="KQ459680">
        <property type="protein sequence ID" value="KPJ20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF52"/>
    <dbReference type="STRING" id="76193.A0A0N0PF52"/>
    <dbReference type="InParanoid" id="A0A0N0PF52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="45219" checksum="BEA41AB9CE80D2A7" modified="2015-12-09" version="1">MQEGLRRLFDSYRRHPKLKSLTENSSYGVHSDAFGQFFAQWQFKYPFRDRVRYLNKYEHFKTYIQGLDMHFVHVKPKVDGNTKVFPILLIHGWPSTFKDFYDVIPILTTPRPGYDFVFEVIVPSLPGYVYSQATNKRGLAPTQIAVILRNLMKKIGHEKFFIQAGDLGHFIGSHMATLFPDQVLGFHTNTPINASKLANLIWLLGSIWPTLVAGDQADKMYPISEKLSYYLEESGYMHLQGTKPDTIGYVLQDSPVGLAAYMLDRYMAFSNSSFKNTEEGGLDNISTFDMLDNVMLYWITGSMTSAMRLYKETFASETELILARIPTPVPTWALRLKYELCYHPDWLLKLKYPSLLGTTSLNDGGHFAALEKPKELAADVFKAVKSFLEFYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFF6</accession>
    <name>A0A0N0PFF6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein purity of essence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01028446">
        <property type="protein sequence ID" value="KPJ21184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFF6"/>
    <dbReference type="STRING" id="76193.A0A0N0PFF6"/>
    <dbReference type="InParanoid" id="A0A0N0PFF6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="8141" checksum="8AB18FCA32DC13B7" modified="2015-12-09" version="1">MQKKSVLLMTSNAIIKVVETLAISDRKRAMSLAPHQLMLTTRLMLLLEYLMRHLYDAPQTLLQQVIILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFV7</accession>
    <name>A0A0N0PFV7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01067109">
        <property type="protein sequence ID" value="KPJ21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFV7"/>
    <dbReference type="InParanoid" id="A0A0N0PFV7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17790" checksum="DC02F64445D17356" modified="2015-12-09" version="1">MTALEQDVLCGSLPKVQNPKLINNLRRQQIWLTDAEEDMKDISILIGSDQLGLIIKENFIRLDENLVAIPTKLGWTLQGPIQGDFSTSVRGISRNKMVFQHPKEVFSTSCSLVGRVVRATDRANKRHVSKNITQNISGKEWQSYRYHNQVGKHDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I522</accession>
    <name>A0A0N1I522_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brevican core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I522"/>
    <dbReference type="STRING" id="76193.A0A0N1I522"/>
    <dbReference type="InParanoid" id="A0A0N1I522"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="20489" checksum="6FDECD0C310E65B2" modified="2015-12-09" version="1">MSWIADTKTVNFPTSLNSISKSECSSCNDDELGVTRWTMPLLKSGEKRYYLGIFFKANWFKAQQYCRFHGMHLASISSQEENDRLEKYVKDSGYGREHFWTSGTDLAEEGNFFWMANGRPLTFVNWNAGEPNNFRYENGEEENCLELWNRDDKGLKWNDSPCSFETFFICEVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6T3</accession>
    <name>A0A0N1I6T3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6T3"/>
    <dbReference type="FunCoup" id="A0A0N1I6T3">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I6T3"/>
    <dbReference type="InParanoid" id="A0A0N1I6T3"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH15-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="8">
        <location>
            <begin position="949"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126736" checksum="568E0C6189AD1C96" modified="2015-12-09" version="1">MIRQGSIDDINAQQFLKISNYEDTVRQLDIYYAIVKRQLLRFQSPITGLFPVLSSDLHVASVRDSIYCAAAVWGLYQAYRRIDDDRGKSHELGQSTVKCMRGILECWIKQSARVEAFKTRQSAAHALHVKFHLTTGEPVLSDEEYHHLQIDVVSLYLLFLVQMITAGLQIIYTQDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNDGKPEIHASSIGMAKAALEAINGCNLFGDKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDAALLPTISFPAFATHEELLVQLTKNNILSRLQGRYGFKRFSRDGYKCALEDPNRRYYHEGELKEFEGIESEWPLFYVMMIIDGVFRTLPEQVEEYQKLLKSRIYMDEYGDPVIPWYYYVPREGIENERSEPYSVRRMPANQADDSVNKGGLFLWAQSLFVLAQLLTGGLLHVNELDPIRRYLPSYNRPRRAGRYSAFQGTATDLVVQVVLIAESMRLQAMMGTYGIQTQTPHEVEPVQGTATDLVVQVVLIAESMRLQAMMGTYGIQTQTPHEVEPVQVCSSTQLVHVYRELGVCPKLKLTGRPIRPVGSLGTSKIYRVCGMTVLCYPLIFEVSEFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLVREEHMRDPHFKQMLDLFAMLKKGHCDGVKVRLGRLQNLISSSCIEHLDFMSQGEFPSEMFSQFRQLEHEYIGYQSLTDVPRTLTYREEDLNCEEYKHKPTHDVVHALRSTNNIFAQCQLWGILLEREGPMYEVNGKTALESLKGLYHSAGVLRHWRAVRYCSSLLNHTVDSISPFITTVLVNGKQLTVGVIGRKETVFDKPMTPGEIQSVMYSTIQPYDVIGAVLQQEIVLYCGRLIGTNPDMFRGILKIRVGWVLEAIRTYLRLSPREGRAEAPLESLSPYRLRTLLHKVLTVSDWADEQGLTPLQRRELEGCLCRVPKHFYIQVWDILLRTPKGIIVQGHAIPAQPTLVNMSRSELSFALLVEAALVRVESAPRRQLCVELLCVLATILRRNPELYLQQPLDLDQLLDDAHYTYAKDSGMSESEARGRGGLSAAAPAVTLGYLARAVVNSVLQAAAAPHLQPAPDDSCLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8N7</accession>
    <name>A0A0N1I8N7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Breast cancer metastasis-suppressor 1-like protein-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8N7"/>
    <dbReference type="FunCoup" id="A0A0N1I8N7">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8N7"/>
    <dbReference type="InParanoid" id="A0A0N1I8N7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000002">
        <property type="entry name" value="breast cancer metastasis-suppressor 1-like protein-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="28942" checksum="9505263EFF88A8D6" modified="2015-12-09" version="1">MPSMKVEGDSDGDGDMSGGDTERSGGSSRGPDRDSSAEEADEPDSDDSSEMDESECERRRNECLDNLSNLEHQFSLLREQLYNERVKHVEYQLAEVRGGRSQEYLGPLRRLQENMRVRIEVAGILKQMRIENIKHIYDAEEQAAHQHFKFSLLREQLYNERVKHVEYQLAEVRGGRSQEYLGPLRRLQENMRVRIEVAGILKQMRIENIKHIYDAEEQAAHQHFKVYSVKDNDFVLKLYAFVIHFALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAP2</accession>
    <name>A0A0N1IAP2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAP2"/>
    <dbReference type="STRING" id="76193.A0A0N1IAP2"/>
    <dbReference type="InParanoid" id="A0A0N1IAP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="2">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="694" mass="77350" checksum="D2CFBB1DD7F7B30A" modified="2015-12-09" version="1">MAAITPRRSLRIPHMHTPKMTERKKGLFQGEAPPQPESLTKHRRLPVLDSESDSDDCDLGIISTIDSSSGEETDQNTPKTPERSLWHETQSQSRKVKETHYLKNFMKSPFTLKKYQTQYSCSETKCGSSSTPATPHLRNHPVTPSSTHSCTSIHTTSSTSSKARKSLASLIADTESCSSSLKDLNFDSDSATDSKENTPTKPLRRSSRKHKNSPKLQSFKGVLLEQKKNVSPIKYPVVCLTKMDFTNLISPTQMLKTPHNTTEAKDSPPKLSHNRRSILEIEESPQSVCDSEKSHKRLHYDGMSDNGPNSKLPKLDPSVAPKARLSLFNSDKLKEILSAKSFYGKNNPDLNTSITTKISNAIESTATHPRRSFGHSNRRKRKPGEINMGVKHKIRKPKYNKPNISSIKGNTKTSGEIVTDTLNKSIISQNSTNDVELISQELVTDKVNPFVQEQQTIEALLSQWTEEEVPETELSYRKAEVPCFNNSIIEETSTIFQPVTAIPVESLPLPEDSDTIIIELGASNNGQGNAGQEDIVMVDSMTDKESKTEFLPVDGGFIVVEDNEIKEPEELTDLDAIERELKMLDEQILHMAQSNNINAEAVLASTEKDIPRVSPELISDEENNTSKTKPMKLFSIFNKPNPGVTSLPKGTDKSRRSILKSIKDQYVIDAGQKKFGVTQCNECGVIYQVNYQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAW1</accession>
    <name>A0A0N1IAW1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor eIF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein translation factor SUI1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460246">
        <property type="protein sequence ID" value="KPJ16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAW1"/>
    <dbReference type="FunCoup" id="A0A0N1IAW1">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IAW1"/>
    <dbReference type="KEGG" id="pmac:106709394"/>
    <dbReference type="KEGG" id="pmac:106711442"/>
    <dbReference type="InParanoid" id="A0A0N1IAW1"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000010">
        <property type="entry name" value="Protein translation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12446" checksum="28EB2CB52BCA35AE" modified="2015-12-09" version="1">MSIQNLNTFDPFADAIKSSEDDVQDGLVHVRIQQRNGRKTLTTVQGLSSEYDLKKIVRACKKEFACNGTVVEHPEYGEVLQLQGDQRENICQWLTKSGLVKPEQLKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBG8</accession>
    <name>A0A0N1IBG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Juvenile hormone epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459630">
        <property type="protein sequence ID" value="KPJ20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBG8"/>
    <dbReference type="InParanoid" id="A0A0N1IBG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873834" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="445"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="890"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1299" mass="148477" checksum="B2B8C3BEFD822699" modified="2015-12-09" version="1">MAKMLGIIVLLVILAIAYKVWSSQNKEPPQLPRLDPQEWWGPNELRGKEDKSIRPFQVQFTDEMINDLKNRLKNRRPFTPPLEGVGFEYGFNTKSIDGWLNYWAEEYPFKEREAFFNKFPHYKTNIQGLDIHFIRVKPQVPSNVEVLPLLILHGWPGSVLEFYEAIPLLTQRAPGYNFAFEVIVPSLPGFGFSDAAVRPGLATPQIAVIFKNLMSRLGFDKFYLQGGDWGANIGSAMVTLFPDVFLGYHTNMPVALVSVALTDSPSGLLAYILEKFFLWTRREHRNKVEGGLGFRFTKEQLIDGLMVYWTTGCITTSMRLYAEDLSKKKRDLGLDEFTTPVPTWAFQAKNEVWYQPPSILKTKFINLLGTTVLEDGGHFLAFELPQIYADDVFKAMLGIIVLLIILGIAYKVWSSQNKEPPQMPRLDPQEWWGPNELKGKEDKSIRPFQVQFTDEMINDLKNRLKNRRPFTPPLEGVGFEYGFNTKSIDYWLNYWAEEYPFKEREAFFNKFPHYKTNIQGLDIHFIRVKPQVPSNVEVLPLLIMHGWPGSVREFYEAIPLLTQRAPGYNFAFEVIIPSLPGYGFSDAAVRPGLATPQIAVIFKNLMSKLGFDKFYLQGGDWGSVIGASMVTLFPDVVLGYHTNMAMTHNGKSTLKTILGAYLPSLVVEKHLASRMYPLSSIFAFFMEEFGYFHLQATKPDTIGVGLTDSPSGLLAYILEKFFLWTRREHRNKVDGGHGFRFTKEQLIDCLMVYWTTGCITTSMRLYAEDLSKKNRDLGLNNFTTPVPTWAFQAKNEIIYQPPSILKTKFINLLGTTVLEDGGHFLAFELPQIFADDIFKAMSKILLGFGALVVVYIAWSALSSESPKRLEIDQNEWWGPNELKGKEDTSIRPFKVQFTDEMIKDLRNRLKNHRPFTPPLEGIAFQYGFNTKALEPWIKYWAEEYPFKEREAFFNKFPHYKTNIQGLDIHFIRVKPQVPAGVEVVPLLIMHGWPGSIREFYEAIPILTRQQPGYNFAFELIAPSLPGFGFSDAPVRPGLSTTQTAVIFKNLMMRLGFKKFYIQGGDWGSVTGAAMATLYPEEVLGYHTNMPVVQGGFKTMLGAFFPSLVVESHLADRMYPLSDFFAFLMEEFGYFHIQATKPDTVGVALTDSPSGLLAYILEKFSTNTNRNHRKLPDGGLERRFTKTQLIDNLMVYWSTNRITTSVRLYAEELSNKNRELEIDEYPTPVPTWAFQAKYEGMYQPPSILKTKYINLLGTTVLEDGGHFLAFELPEIFAKDVFKAVDAFKNWHKNDAKNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC27</accession>
    <name>A0A0N1IC27_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">apyrase</fullName>
            <ecNumber evidence="3">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_00853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="3"/>
    <dbReference type="EMBL" id="LADJ01006163">
        <property type="protein sequence ID" value="KPJ20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC27"/>
    <dbReference type="STRING" id="76193.A0A0N1IC27"/>
    <dbReference type="InParanoid" id="A0A0N1IC27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1201">Platelet aggregation inhibiting toxin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005732949" description="apyrase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="349" mass="38724" checksum="151D9EF9CA1A755B" modified="2015-12-09" version="1">MSALKWFVSVAVFTLVDGFALPFEGLYELDIIHYNDFHARVRISNTLLKWNVTQEFMNLLPHDAHAIGNHEFDDGPEGLAPYLRALKAPVLAANMDVSQEPLLQDLFTPHIIVKRGGRKIGIIGLITTDTKKLSSPGNVVFTDPLEATDREAKILTDKGVDIIIVLSHCGLEIDKQIAREHGKHVDIIVGGHSHSLLWNGPAPSGENVEGSYPVFIETSKEKKHQVLIVQASAFTKYMGNLTVYFDYLGRYVKWEGGPIFLDRSISEDEKIKKKLEPYAKLVHEAENVPVGETLRTLSADDCVFGECTLGDLLVDAMTDYARANVISDYDHLAFIQRGNIKASILSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICN0</accession>
    <name>A0A0N1ICN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICN0"/>
    <dbReference type="InParanoid" id="A0A0N1ICN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="45270" checksum="6B2AEBCAE8C1BE90" modified="2015-12-09" version="1">MNLNGDPNTDDYFVTAVHIFKYCGAESTETLRVDALMDKFAPFIKTNKAEYSYLKSLLDPEENNPEVSVLTLASVLNKYSENQKIKADLDESFNLKNGQGPHDSDSGISTEAVHIFKYCGAESTETLRVDALMDKFAPFIKTNKAEYSYLKSLLDPEENNPEVSVLTLASVLNKYSENQKIKADLDESFNLKNGQGPHDSDSGISTEGFQLLEDLQCELKEKAHLAQQLRSQLDFTDRQHEEQLASVTAERDSLLAHLNLLREENISLSHVKRDYEETCDRLCCSERALDEATRDLDVTRKRARVLVEQVAALESEKVILQELLNKSKEECHRINEMYASRQSALLEECESLRGQHADLASRLQDHDHYMQQLIKEKVQSENIVVFKLQKISLFLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICU3</accession>
    <name>A0A0N1ICU3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICU3"/>
    <dbReference type="InParanoid" id="A0A0N1ICU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="20039" checksum="B60F2B28965C5424" modified="2015-12-09" version="1">MVCIAGRLRRIRRVRGRLQRARDSTRERYCRPSALPHFSPTPPPPLSLYCDDLMEFVARATRAASSGAAVAAAPTRGTSPTKLSVPAHSHLSPIIRRIDSSSSNDIPRRCLEMSTSELPCVGVGEDRLLPHPDDCELFYYCVGDVAICRQCPSGLHFSPTQHVCERAARAGCDSALALPLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE67</accession>
    <name>A0A0N1IE67_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE67"/>
    <dbReference type="STRING" id="76193.A0A0N1IE67"/>
    <dbReference type="InParanoid" id="A0A0N1IE67"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="7">
        <location>
            <begin position="120"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="795" mass="88916" checksum="71CA0FCEB0A82231" modified="2015-12-09" version="1">MGELSAPEIEGIYETQMSLEFRVLVQLGCICAVDPQEARKMIQSGSNIMDTFTLSQLQFKSVAHQPYLPKQDGVSPVKHIFLYQHSALNSSRSMWALILGPIKKAYIFVLDTVKTNQLPNMNTLFAAERTAKHVVESEGRAVWRGVGRALQRYRDERCGATLLALQTALSPAALLTLVPGLSEFPLVPLHVRDVETLYSTLEWQRIGARAIVRHYLNLDSVLNMTVEQCRYFHVPVGNMPSDPTLFGADLFYARHLIKNNFVLWCSNLERPDLGGREIDDNRLVSEVEEMSGCTHNASGAYGVCVELESDALSVCALLQAQHVLHAEGTSAATSFGAQHNTIQDAIASTTGASATTNYDEAAQCGAAFKILRTMIASWLRDVTLYKNVFADYQISHFYRWLKTPTSLLYDPALRRTLYNLMKKLFLMLVAEFKRLGSAIVYADFNKILLYTKKNNVMDGIGYVEFVVQSIRNKELFHGIDIRYKQCWSYLMWLDEANHAGIQGKLPAGLVEVGSSQVPAPSESNSQDEGEVTMQWNLAEFLPHAVREQFTAAVAGFLSAAYSNPDKLPALVAGEISQKLFRVTEKINTRMPGLRPGDISPQPGLRADAFTEDSTPALLFVNAVCKVLSLDASIEDQVTLLRRNLLRLIGVGEFGSAAQWREPCTSCVLPELICNVCNACRDLDLCRDTHRDIVNDMPVCLCPTCGTPYDNQELEWRLIEVMNRRAMTFTLQDLVCTRCHQVKRENLAVVCDCAGDFALMVPQKEIQTQLVTFKTIAEFYKMPLLLELIEFNLSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IED7</accession>
    <name>A0A0N1IED7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette sub-family B member 7, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035457">
        <property type="protein sequence ID" value="KPJ21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IED7"/>
    <dbReference type="STRING" id="76193.A0A0N1IED7"/>
    <dbReference type="InParanoid" id="A0A0N1IED7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="34281" checksum="906FB75813410F20" modified="2015-12-09" version="1">MAAALLSNRKFDKFIHNHIKLNRSFCNIKSVVLNKPQFSIICKQCASASSYRYYSSSSPNNAAGSDTAKNVLAAVLANKPKTGKIPVGIQKRDCFHPGASVLSREDINLGDAKPVSGMDMIRGMMEYVWPRDNAMIRNRVMLSLSLLFGAKVMNVSVPFLFKYAVDEVNHVATTPAGDALLGMATVPQALGTTAFSLLFLKAHRYRGEREAWAEGAGLLDVPIYRSARLVRLYCNDGIARATAAGFNELRNAVFAKVAQHSIRRLACNVFTHLHNLDLSFHLGRQTGALSKVRCWPTKTCNVVVNALILLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF85</accession>
    <name>A0A0N1IF85_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460765">
        <property type="protein sequence ID" value="KPJ12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF85"/>
    <dbReference type="InParanoid" id="A0A0N1IF85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="12254" checksum="6206D29E6ECE472F" modified="2015-12-09" version="1">MTASLQTPPTPRQDPIDMTMPEGATPPSLPLFQNSTCLDDCLRNITSLSLIFRRQYCADQCIQSKYTVLTTAVDGISCLSNCPSITQGTPVCGTDGVTYPSLDALECSQSCGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFP5</accession>
    <name>A0A0N1IFP5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFP5"/>
    <dbReference type="InParanoid" id="A0A0N1IFP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="321"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="44178" checksum="3324035F95B6B256" modified="2015-12-09" version="1">MVSSFPDLGSPLKFEVTKFGNPTILWGDYRFIKKLTRRLKTWWELTVLETSKGSQALWDGSFRFSKCNVGKVTTRWQCTTKSRTKCKAYIKTTNDVPIFGKTKAGNPVITLGKYRFNRVYKYKGPKARWTCTRTPAGCRASVMTIDDIIIRCKEQVVFCKSRYGRPMLQYGQYRYNNRSNMKGPRCSWNCIKYQTGCRATILTYYGAGIRFELTRYGNPVMVLGKYRYNRWSYSKGHIVRWTCIKNQNGCRATVTTYDNVIIKTNMPKFTISRHGRPVMLLGSYRYNKWVGSKGRRVRWVCSQKTAGCKAKIYTFDDKPIFTTSNRGNPMIQMGRYNFSLTKTGGGPKRRWVCSKWGSTGCRATITTLDNVLVKSNLNHMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG59</accession>
    <name>A0A0N1IG59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460546">
        <property type="protein sequence ID" value="KPJ14058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG59"/>
    <dbReference type="STRING" id="76193.A0A0N1IG59"/>
    <dbReference type="InParanoid" id="A0A0N1IG59"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="RanGAP1_C_sf"/>
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        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="513" mass="54897" checksum="2DE044BB4D7C218D" modified="2015-12-09" version="1">MATFDFNSINSALTDTSRLETGVDFSGKSLKLDTEKDAQPIIDAINACPDLQYLTLTGNTLGVAAAQAIAKALEHHPELKIARFSDMFTGRMKTEIPPALSALGEGMITAGARLSVLELSDNAFGPIGVQGLAKLLQSDVCSQLQELRLNNNGLGITGGRLLAEALSASPRKLKVFIAGRNRLENDGATALARVFQGMGTLEEIAMPQNGIYHKGVSALSEAFKHNPNLSCLNLNDNTIGSKGAEAIATVLPGLKKLKSINFGDCLLKSKGAKALAKAFKDNSLLLESVDLSHNEIGREACIEVVDAVTALPDSTDRLSRVVLAGNSLGDSTNKKTMKDKLGSSAELSDGEGSDEEYVSGSESDGESDGSDDENTEDSAPEDAQHVIKDPSDLITAYVEATFSVSGLSDESQLAHQVALDLYPIMLKRAGQQHASAWLLANTMLRGLGLIKSENKQYRIRWKTSGCYRMLAIAVTSPTFPIPLKDTLKFFIASRLTSLADRTIVEQHPQLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG73</accession>
    <name>A0A0N1IG73_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dedicator of cytokinesis protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460886">
        <property type="protein sequence ID" value="KPJ11088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG73"/>
    <dbReference type="STRING" id="76193.A0A0N1IG73"/>
    <dbReference type="InParanoid" id="A0A0N1IG73"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DOCK"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="8613" checksum="BF159D4AEC7EFF81" modified="2015-12-09" version="1">MGDKLKRLSGRPVAEQILQYYKHNNVDKFVFSRPYHKPDDSLTGSNEDVSSQNEFATRWLERTELEISDKLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGU8</accession>
    <name>A0A0N1IGU8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ferric-chelate reductase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460689">
        <property type="protein sequence ID" value="KPJ12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGU8"/>
    <dbReference type="FunCoup" id="A0A0N1IGU8">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGU8"/>
    <dbReference type="InParanoid" id="A0A0N1IGU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF171">
        <property type="entry name" value="OS01G0895300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874028" evidence="10">
        <location>
            <begin position="29"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="11">
        <location>
            <begin position="205"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="330"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="620" mass="68310" checksum="5A133B024EFA7585" modified="2015-12-09" version="1">MLPRKRSMKWFILTVFLLIKYSEQYGSGAPPGINMLPRKRSMKWFILTVFLLIKYSEQYGSGAPPGACVDQTPRHSGIPAQSSVPPYAIYTSSQVRQGDVLNVTIGSALGAPVIIGGFILQARQVQNYATFWKNVESPVVEVVTPDTVITTTQPTVTTRVPAAPAATTETNRKTTTAKPDLIYQGCEDTKLCFGVPQNCIKSGNCKAIVAVFVAGDTYTFEIQGTDNPKYVAAGLSTDNKMGEDSAMECIRNDNGRVTLFTSWTYPKAEPYVRRSDSPQDIVQLLESSIIDGKLYCKFRRDTVSVVMGQTFDLANNKYNLMVVSGDSMKDPDRVGFHSLAYESTGTPLALATVGAPAAASKLLIKLHGSFMLLAWLGSASIGILLARYFRQTWVGKQLGGKDIWFAKIPYFSMKCTHQYHRILMVLTWLLTMLGFILILVEVGGWSSAGGNPHAITGIVTVILCFIQPIGAYFRPHPGTKKRPIFNWLHWFFGNSAHILAIVTIFLAVYLQKAELPIWSVYILAAFVAFHVIMHIILSLTVCVSEGQISNGRVNSFPMKDMMGQPRQLAHVDRSTDAPFSSFRRQVLSIYVPIILIIVVAMICLVALAPIADTYSNITGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHI8</accession>
    <name>A0A0N1IHI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle glycoprotein 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHI8"/>
    <dbReference type="KEGG" id="pmac:106711816"/>
    <dbReference type="InParanoid" id="A0A0N1IHI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="438" mass="48099" checksum="2B4BD0215B98F6BF" modified="2015-12-09" version="1">MDATRRELSSYKLKKMETDLEDALEVAGIGKYQYLHNTLMVVILASAMIEMIGCSFLLPSAACDLDLPDNLRGIMASIPNIGVILTAPLWGRAADNLGRRPILLLSTMFAGLFGFIASFMPTLLTFAICKLAGSFFLSCPTSLCYAYAGEMIPRKKRDVTLLIFNALLMLSASLTPILAWTVLSNDWLGLKPWRLLTMVYALPLFLSSLAVPWAQESPKYLLTKHKYVEALEVLKYIYAVNTGCDKESFCVTTLKRSVDDSGKEIEVGVQNRGSSLLSLLRPPHLQWLALLGFLMFGLLSLLNGLYLFTPDTINKLMNPSNAAYGTICEVINLRVNTTTTKCSPSISRGTFEIMVYATLVYGALVLMLSFTPVSKKAQLVTMFLVVGAACINADLTTNRLVAGISMSALQVTALGLGPLTAYAVHLFPTHLRYEKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIN3</accession>
    <name>A0A0N1IIN3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIN3"/>
    <dbReference type="STRING" id="76193.A0A0N1IIN3"/>
    <dbReference type="InParanoid" id="A0A0N1IIN3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin" evidence="3">
        <location>
            <begin position="363"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="3">
        <location>
            <begin position="546"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="696" mass="79492" checksum="9CF8CDAFDEE2893D" modified="2015-12-09" version="1">MMFIAEFGPWYISYDVSRILPSVCPTKVVCERDDDQFCQFCVYCKELNIPHFPDMVFPKNILNLKHANGACINFNPLDALKRVSSRVQAIEVSCAEAWQESRPDAEKKKQNFDWTFSTDYKGTLSDKIVVEPTDETINFEILKQKDQILFYHDLTLFEDELHDHGISKLSVKIRVMPSYWYVLLRYFLRVDDVLVRSHETRMFHMLNTNYVLREFTAKESTARDLNRVMPSYWYVLLRYFLRVDDVLVRSHETRMFHMLNSNYVLREFTAKESTARDLNMPTTQMKEADDVIPFLPLKHKCVNLVLNNGANIAAMCGFTLSMRTYSQGSRTVSTYLVQKGSSQNVVAVKVKNLFKMQHGLGWPHTLRVAQGNEALLKLDRTLEQQNSCEITPPSGLTFNINSPPSTRYTKWTDGCGVRVRNVTMNDEGRWRLTANGSNKLTGWTELFVEESKTSYSASPISLQDGQTEAKIELTTLENSYCLVKKPFAESSLVPGQCSVTLDRTTRAIQGVWNVQLGLPGQIVELELQRQITVETRELQNSEMEDIRTIFVQKNMTFTIMCRASISLSYCWFQHPNGTQYTPGRLETDDQLFWYTGENLQVGDCGISFAHVTSEDAGKWTCHMGPREQLGVEIIDSVLLRVTGPLAANKKEVVANIGGSATLFCHTANGNRPLEYCRFLSPTFVGIRVDQSVSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INP3</accession>
    <name>A0A0N1INP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative histone-lysine N-methyltransferase Mes-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03598</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INP3"/>
    <dbReference type="STRING" id="76193.A0A0N1INP3"/>
    <dbReference type="InParanoid" id="A0A0N1INP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        </location>
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        <location>
            <begin position="609"/>
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            <begin position="10"/>
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            <begin position="613"/>
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    </evidence>
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    <sequence length="1043" mass="120046" checksum="8968500D856AD690" modified="2015-12-09" version="1">MGTENIDNPENCKNHEDFNESDNNRPKNVPDKNLSETNDIEMDEEIINLPDNSENDVDFIEPDNQISKSILGKNLDESNDIKMKEICENQVLNVKNSSTTICESIELNKSQKRNKLKDIENNQTSENQKSDSEESEESIDSRSLKDDEQRENQILDDNHEKLNNANVKLINSNDNEVPNSFSSGYSSSIPDENDVEYNLIQIFNDKEISSNDCDSTLTEEKLPNSKTLPEVIRDNSVINNIDNTNNFIDKVNNMLENKVIGEVHKNILEETNIEDNPDQKQTSVFNNEMNSTEDVTKEKSTSDNQSAKSLNSDVESVTSENTEELSPKNLKSELDKNETNIEESQNTNWKVKEVIDDNKSLKITLDRTVEKKSNKPSKNEFEDPEFLKYLEFRQDALIDEHPELTQDEITRYLYKTWLYEESSKSESKRTDEMEQANLVKGLKKETTQPKRVKKKIKVDKEINDDEDFIPKSKSKRRIARPYYNEDYNDNSDIDMEDEVQLFEIFKNKSNRQFKEKNNENSNETQINIPNGSIEESRNDANFLSDDDFDQVEEYFRQLTEPKPNLFKGLLREKVCEICEKSGNLIKCKGCHYVFHVECTKKETEVIDKQLPTRGRKKKKRNRGRKQKGLDDSNGLDGDSQSDEKSQELNASEENLSIDDIESHIIVDANNFEAQLSDKMKEILDTQNEYDLDSSEQELDWSDTEVGKCKIIDIKLPKKNQISDTDYSDFKCHNCVRYDKPICFVCRSATSPKDGIEFRQRCQLAHCNRYYHLECLEHWPQTQYHSGEVLRNNKNIKGFFEPVVCPRHVCHTCVSDDPRGCKTRFSGDKLARCVRCPATYHSFTKCLPAGSQILSASHVICPRHYEHRPGKVPCHVNTGWCFICALGGSLICCEYCPTSFHAECLNIKPPEGGYVCEDCETGCLPLYGEMVWVKLGHYRHFVYFPGGYMCEDCETGCLPLYGEMVWVKLGHYRWWPGIILHPSEIPPNILAVKHSPGEFVVRFFGQYDHYWVNSNTCTSTGALSCFFMLLVSGILSLVAASYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INZ3</accession>
    <name>A0A0N1INZ3_PAPMA</name>
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        <submittedName>
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    </protein>
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        <name evidence="9" type="ORF">RR48_02614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="158"/>
            <end position="322"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="389" mass="44461" checksum="27CBF771209710B0" modified="2015-12-09" version="1">MSIAYIQQRRKPRLWVRNFFKKRETHGVCSSLYNDLVIQDAIGYKNTLRMSPEDLEILLQKVSPKITKHDTNFRQAISPKDQLLVTLRYLATGDTYTALMLISRISKTKISVFVPEVCKAIVQVLADYVKMPTTTEGWEDIAQNFKLKWNLPHCIGHIDGRHIEMIRPKNGNDYLNYRKNFSIVLLGLVDANYNFLYADVGTPGKISDSEVFNSSNLYRSLQNNTLNLPPPKPLPGRTQPSPYVIIGDDAFALSKHLLKPYSYYQINGHPEKMFNYRLNRGRVVVENAFGILSARFKVLRQSILVSPQKASTIVLACVYLHNFLRKSEKSHYLYTPSGSLDEINPVSGEITLGTWRDRNQGMISLQRVPSMDCAEGVAVREEFKAFFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB0</accession>
    <name>A0A0N1IPB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPB0"/>
    <dbReference type="FunCoup" id="A0A0N1IPB0">
        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPB0"/>
    <dbReference type="KEGG" id="pmac:106712708"/>
    <dbReference type="InParanoid" id="A0A0N1IPB0"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000087">
        <property type="entry name" value="WD repeat-containing protein 26 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="515"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="554" mass="61473" checksum="7950E61DC2DB8D22" modified="2015-12-09" version="1">MHQPCANGAVGAQHHVNGDAVATNGDFQPPGRRMSQTDQEIVRLIGQHLLSIGLERSAALLMEESGLHLEHPAAATFRQHVLAGDWLKADHDLRALHDLLQDSPHVDPHNLAEMKFVVLEQKYLEHLEGGRVLDALHVLRNELTPLQHDTARVHRLSALMMCADAAELQARARWPGAGPLSRSAVLARVQAVLPPALMMAPGRLRALLAQAAAQQASRCRFHAAPRPAPHATHIPFTLLADHHCSPDHFPIHQLQVLNEHCDEVWYCKWSPDGSKLASGSKDNTVMIWDFDPVAKRLTFRKSFEGHSFGVSFLAWSPDGRYLLSAGHEDCPDIWIWNMETERLHVKMSHSTEDSLTAAAWHASSDKFVCGGARGQFYHCSADGVLLNSWDGVRVNALACRSDGRSVLAADTHHRVRQYDFTELADRNVIQEEHAVMAMTLNAADTLLLLNVANQGVHLWDIRARALVRRFRGLSQGHFTIHACFGGAQQDFIASGSEDNKVYIWHINGEEPIAVVSGHTRCVNAVSWNPVHHDVIVSASDDFSLRLWGPRDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQV0</accession>
    <name>A0A0N1IQV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044240">
        <property type="protein sequence ID" value="KPJ21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQV0"/>
    <dbReference type="InParanoid" id="A0A0N1IQV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="7855" checksum="8D3E4A98915E0FFC" modified="2015-12-09" version="1">MRNYADGTFEERIPLIIVEQAEEGTTRTSEGEDNETSEVQASSRALSAATSREEDDESSKDASSESKSPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGE5</accession>
    <name>A0A0N1PGE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase WRNIP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGE5"/>
    <dbReference type="STRING" id="76193.A0A0N1PGE5"/>
    <dbReference type="KEGG" id="pmac:106713310"/>
    <dbReference type="InParanoid" id="A0A0N1PGE5"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="531" mass="59256" checksum="0AC08365C05D9174" modified="2015-12-09" version="1">MSNHNLNNPKSDKDKEPGLISCPVCNREFRNEAIENHVNKCLFLLNSQMEKTFKRDNSHLKENQFSPKRLKVDSGIETNLNSKDITNEPHASSSKNPCKTKSQEGIPLAEQMRPQHLDDIVGQIEAFGPGSMLRSILEQKKISNMILWGPPGCGKTSIANVIAHICKESSNLRFVKLSATMAGVNDVKEVVKIAKNEAQYKRQTVLFVDEIHRFNKLQQDSFLAHVENGTLILIGATTENPSFSLNNALLSRCRVVVLSKLTVDNILQILIRSVVRNKLAVLVDAIEDIKEDINESKDIPIIENKSLQWLAEVCDGDARIALGALELAITAARAKVKTNKNVSQVITLSDLQNGIKRSHVLYDRQGEEHYNIISAIHKSIRASDDNAALYWTTRALHSGEDPLYIARRLIRIACEDIGLRDQNAVVEAVACLQGCQHIGMPECDVLLVQCAVSLARAPKSREVYEAMKRCQAFLNDTKGSLPSVPLHLRNASTKLMKSLDYGKGYNLLHKNESGLNYMPEGMESINFFRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGV1</accession>
    <name>A0A0N1PGV1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA N(3)-cytidine methyltransferase METTL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methyltransferase-like protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02292</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50956"/>
            <dbReference type="Rhea" id="RHEA-COMP:12849"/>
            <dbReference type="Rhea" id="RHEA-COMP:12851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74894"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:50957"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460497">
        <property type="protein sequence ID" value="KPJ14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGV1"/>
    <dbReference type="FunCoup" id="A0A0N1PGV1">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGV1"/>
    <dbReference type="InParanoid" id="A0A0N1PGV1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000279">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="360" mass="42524" checksum="110ABC402629E429" modified="2015-12-09" version="1">MELDENVGANGDRFVHRLKELSADEKQNLENQNSRIVPEIKAVKLEKDAKRHWDIFYKRNETKFFRDRHWTTREFQELINFDSDERITYLELGCGVGNMVFPLIEEGFSNFYFYACDFSPRAVEFVKQNKLYDESRIKAFCADLTTDDLFDNVTENSIDIASLIFVLSAIHPEKWRHVANVAFRALRPGGVLLFRDYGRYDMAQLRFKPGHKISDNFYMRQDGTRSYYFTEEELSELFTEAGFEIIMNTYVQRRTVNFKEGIDVPRIFVQGKYKKPTKGLKMTMFHRMLPKLYMQLAIKLIQLFYKHGYCRYCLLAIFLEGFGYIEVTIDALILIVSLNRENPINPVDKPYASDYIYHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHD7</accession>
    <name>A0A0N1PHD7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHD7"/>
    <dbReference type="STRING" id="76193.A0A0N1PHD7"/>
    <dbReference type="InParanoid" id="A0A0N1PHD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="250" mass="28674" checksum="36377F054BBE7974" modified="2015-12-09" version="1">MGSLFRSEEMTLCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFHRKFVNEVRRCDEMERKLRYLEKEIRRDGIPMLEIPGECPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNYLELTELKHILRKTQVFFDEMADPSREEEQVTLLGEEGLMAGGQALKLGACTVTLTRESTSHHSGKHWSQPHEGGANTTESMTRALISDDPNKHMGHVQLGQSDVWTVIQCTAIKDQRYGPWSYYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHQ6</accession>
    <name>A0A0N1PHQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459736">
        <property type="protein sequence ID" value="KPJ20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHQ6"/>
    <dbReference type="KEGG" id="pmac:106709205"/>
    <dbReference type="InParanoid" id="A0A0N1PHQ6"/>
    <dbReference type="OrthoDB" id="7283135at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="757" mass="87171" checksum="BDBBE1E3559F93F3" modified="2015-12-09" version="1">MDEKNKSIEDITKDMSELTVLSFRKLDDVKKLARHFQFVINHPITQGNQVVLKYLKNLDEMHKDIFLKKRDGVNVEYIFTTEKKSSMQRQRFNSLPVNEVPEILKSEFLTIDNAKQVHICTDCNVEIELFDDVPLMESLQKHFSLEAHMPKLKRESIDLAEPILLPKMSRRLSALESGDNQNMEQIIQMLKPAEKLDRSFSAMLESALIKLLPDNSEASIDAAVKFYQEAYEKLCSNISVIDFSTQTSSVAPIIMSIRDNVNQNFSVDANKNYDNDENEHTPDKPMKNQIKKYRYYGPIENNIAKLLLNHKLLTLVDDRTGKLAFFCIACEYYTLRFRYDSVLNHVFSETHIHNLSCILQADKNIPFSMGTATMDKIKDMNKDFLRNHYIIEDNNGPNCNLCRTTLDNDSMILHILDENHLGKLSDKLYRKMKANNPDGQVPEEWGPKSLDWTKFLASSGKPLNNRDHVVIENFIKPSGKIANYCSCCDMTLKGPRQVLFNHIRQKKHLRNAAPHKLTMLYRNHCRPTEYFASFGNHYICTICPEYIALPSFAAIVEHFESTLHIETIAKLIRSGLYDIDEGLFIMNKISTDLFKCDFCDVTFKDANEAVKHILSNLEHQSALAEVKIRSNKGDIISVYMHGNFILHNEGATFNCEPCKSVFNSIRSLLMHLVYAEHFAKRPTSENVFRFYLELKHNISMLARNKYAYYEFGKLKCGVCDADVEDSENAKKHVVSLRHKENMGASYVNINLDVSAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI75</accession>
    <name>A0A0N1PI75_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione S-transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460941">
        <property type="protein sequence ID" value="KPJ10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI75"/>
    <dbReference type="InParanoid" id="A0A0N1PI75"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="92" mass="10581" checksum="FDC95F41144068F9" modified="2015-12-09" version="1">MFGCIDGHLFKEAAAVHYKNDKTVKAKKHDDFAKNVYPAVLNKLENKGHLALGKIPNLKEKYLSFKKLYDTVFFFPKIQGYVSKLPTPVYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIH0</accession>
    <name>A0A0N1PIH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460968">
        <property type="protein sequence ID" value="KPJ10229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIH0"/>
    <dbReference type="STRING" id="76193.A0A0N1PIH0"/>
    <dbReference type="InParanoid" id="A0A0N1PIH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUL" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="287" mass="31570" checksum="D1E670D370E269B9" modified="2015-12-09" version="1">MSGRAKKASAPRKKANGYKMPAPIPLGEVIHDTIAKKKWRIGPSIGVGGFGEIYSACEHEGSPKKGANYPYVVKINSSFNPDTISLLKKMLEWPKEILFPVLDVTRLAIRRKDINGQIFDTTYGPNFVKYLLSLLNPDNLAANQMLAMRVLVNAFSDLAGEMLVLAARESLVHCIICLTHLNNNAQIAAASLLLNLSVALAQQPDIAELVDCILHLLNRLTDNEAYFRGLVALGTLLAESPQKLPIQTKIVSNTQLHNRLKKDCNNSTSDANLKKISMCSQEIIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIH8</accession>
    <name>A0A0N1PIH8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper-transporting ATPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052577">
        <property type="protein sequence ID" value="KPJ21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIH8"/>
    <dbReference type="STRING" id="76193.A0A0N1PIH8"/>
    <dbReference type="InParanoid" id="A0A0N1PIH8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000049">
        <property type="entry name" value="copper-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0187">Copper transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="16414" checksum="7E312F9D32713C00" modified="2015-12-09" version="1">MDYCPQIKGMTCASCVSKIEKTVLKLSGVASCAVALTTSKGKIKYDTEMIGPRTICEAINSLGFEATVASTNSRGATDYLEHKEEIRKWRNAFLVSLVFGGPCMIAMTYFMATMPQHSARDMCCVLPGLSLENLIMMLLATPVQVSTLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJL4</accession>
    <name>A0A0N1PJL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin B9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459680">
        <property type="protein sequence ID" value="KPJ20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJL4"/>
    <dbReference type="FunCoup" id="A0A0N1PJL4">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJL4"/>
    <dbReference type="InParanoid" id="A0A0N1PJL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19598">
        <property type="entry name" value="serpin77Ba-like_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF367">
        <property type="entry name" value="GH21475P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879881" evidence="4">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="361" mass="41142" checksum="BB92F43670974C9A" modified="2015-12-09" version="1">MQKQVENLVMSPFTLWTVLAVIAEGASGETLKQISRAIRVSPKLRAKTREDFSNIAQWLQVNTSTVDLEKFNAIFVDEKKLPLNDFVSIANQYDTKLVKLNFTGSKTSELINRAIDNVTHGKIPNLTDPGDFGETQMILTSALYFKGQWTVPFNKSSTTKQPFYDSHSKKIGEVNMMYNRHNYPFANILELNARVIEIPYGKENRLSMLIMLPNPGFSLQDMFLNFNNVPLDTIFENLKLSTDEYGDEEVDCLIPRFKIESSLDLTEMLKRQLNIRDLFDESKVSLPFMSRIPMYVTKVTHKAAIEVTEEGTEAAAVTAAEFTNRIGVVRFEANRPFCYLIIEKTTNSIVFGGFYQYPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKB7</accession>
    <name>A0A0N1PKB7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01026996">
        <property type="protein sequence ID" value="KPJ21149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKB7"/>
    <dbReference type="FunCoup" id="A0A0N1PKB7">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PKB7"/>
    <dbReference type="KEGG" id="pmac:106707531"/>
    <dbReference type="InParanoid" id="A0A0N1PKB7"/>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000247">
        <property type="entry name" value="28S ribosomal protein S25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="167" mass="18966" checksum="C75B758DAF8F4596" modified="2015-12-09" version="1">MPFMKGRAPIRRTLNYLNAGKLVFKDKIRIFSVAYNIYGQNNNGAKDFVFWFLPQIQYKNPDVQVVTMKNLTPSPFIKCYFEDGRRILVDVDNKSKEDILDHLLNTVGKSKEVLEAEATAAEKKDNPANFGVGCERACICEIYGQVPCPGVVPLPKSMRGKYLNQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK42</accession>
    <name>A0A194QK42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK42"/>
    <dbReference type="KEGG" id="pmac:106720413"/>
    <dbReference type="InParanoid" id="A0A194QK42"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="495" mass="54969" checksum="086D095145DEE3DF" modified="2016-10-05" version="1">MKNIFNIICPNKQKHKDETSTDSEDYLAKTIGTFGLWQAAVCVAASLTRFIVMWNMTAILFLTPDTEFECIEVKGIRNVTDNTCYDDCIKYEYNNQGLQTTLISDYSLICDRQWLAGLAQSVLMLGLLVGTFLFGWISDRFGRRNSIVASVLVNVIFMLATPFSPNFWIFSIFRFITGIASGGTLITCIVIIMEIISKNHREAASSVLVQPDALAQASLAIFAYYSPNWNVYVLVYSIASIFILIIVLFIPESPRWLISRGRIDEAIQVITKAAQRNKLSTENIEAIIKNSAEELRINKKEVVNTTYLDLFKTKELAINTTCIFIAWTISGTCFFGINQYMTFVGSNLYVAVVVLGLIQMPVGLGSWIINKYLGRRIASVGILGLGGIVMVLLLFTEEYYWPATILGIIGFSAVSSIFTITYIYASELFPTPLRNMAFGLTSTGAKFGAMVAPFIANLKPQWVPSVVFAGMLFVGALSCLPLPETKGRNLKDTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK63</accession>
    <name>A0A194QK63_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK63"/>
    <dbReference type="FunCoup" id="A0A194QK63">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QK63"/>
    <dbReference type="KEGG" id="pmac:106720199"/>
    <dbReference type="InParanoid" id="A0A194QK63"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ05963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="701" mass="78844" checksum="0F5F18C896A8F5C2" modified="2016-10-05" version="1">MAEANKENTENPLDIDSSNFNSEMYLECLMKLATLKQVMDKEAEIVKQSQFLQSEMQTLVYENYNKFISATETVRKMRTDFQIMQEEMNKLSDNINKITTFSSQISESLKESGTNVNRLCSTRHLLDKLQFLFLLPSQLNKAIIENRYADAVHDYAHAQRVLLKYGNQPSFQSIQTECSEIIYGLKKTLRDRLLNSDTSASELAESVGLLRQLQETDSSLKDIFLSCAESRLDQHLKSLSALVEHTDILEWVEKCNNTLLADLGIVISCYHEMFQDQEANNLPEFAEKVMSQVFHLFEEVVKRPENIGTEILIRGLDKFFRKLQAMSEIISSDVVSQKALDVVIQCINHKATMQYQLIQSQFKDSLMRVRQTLASKGTETVDLKDILNSLQVYLMQKIQASLLDLMAFLQNNLSFGLKPWCAKAVANSCWTVISETLINLSDMVKKMACLKTSNNIPFELLLILAKLCLELQENGVSTLHNHLVKLLEEAAPGLTVDNKDKNSVIVNLSTAAQAALDSEVVFIGQTAAQMLRVSVLARDWLRAPEPRGPRAVCRRVVETLASADSAASQLFPTSVKPSSDSSRRTIWSRAPSSFSPINRIFSERIEVFSPAGADRGALSNGALKVALKALVECVRLRTFSRHGLQQLQVDVHFLQQRLSCMGNDERLLNALLEDALASAQLRCVDPQLMEPSIVDIICERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKL9</accession>
    <name>A0A194QKL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKL9"/>
    <dbReference type="InParanoid" id="A0A194QKL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="92" mass="10101" checksum="BF96F2D1BB3F1EA6" modified="2016-10-05" version="1">MSPTLWCVVASVERVQAEAVPARRRVAAEHVNCTYAHAMLPAHAARQLPVRQPAPLRFPARPFCNTNTNLLTPLVGSHINNVLFWGFPSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKX6</accession>
    <name>A0A194QKX6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ecdysone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKX6"/>
    <dbReference type="STRING" id="76193.A0A194QKX6"/>
    <dbReference type="InParanoid" id="A0A194QKX6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="17389" checksum="BC3D3B5446152F6D" modified="2016-10-05" version="1">MRRRWSNNGGFHSLRMLEESSSEVTSSSALGFPPAMVMSPESLASPEYGGLELWGYDDGISYNSAQSLLSNTCNMQQQQQQPTQPLPPMPLPMPPTTPKSENESISSAAWCVELQRRGREGERPRGDAALSSTFGPDTLTGRRRAARPDVSLPRTQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL96</accession>
    <name>A0A194QL96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QL96">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QL96"/>
    <dbReference type="InParanoid" id="A0A194QL96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1786"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1819"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="3181" mass="349415" checksum="A276A9DDC524C7AF" modified="2016-10-05" version="1">MFNIESYITPILLSYIEKYVKDFRPADAQVSLWGGGVALHNLVLKPDVLQQVVALPFTLVSGRIHELLIRVPWTKIMSEPITITIDTIECILSLHAPPEENPQPDLPTKQVVEAPPGYMRALVRRVVSNISVRVHHLIVKYVQDDIVLSLNIKHLAVDSADSNWNPAFADIEVGEPALRRLVRLDDLTLCLDRADADGKIRFYQEPLLYRCQLDFRVLTRLVSAKRLRPLSVWVRAKAARLAGGASNEQLALLVRLMRERPPPPTPPATTPLFVPPPQTGASSTSLEGVRTESWTEWAWSWLPASDESEDVAPTVPVPVPLILTVYFDDVSFTFKMMETDMSGKRRARPVLQLVATHVAVKFTKCAPTSLRLRAGARLLDLRAHGKCVCGQLPPTHANHEPTIYLSNIVKSEEPWNWPEENFGGRPVETALAVDEQFRASPEPNEASESNVETQWWNEVPQDGDSDELWEQMSPVVFVEYCHDRAPPDSHINPYDKPPLDFEYSDWAEECSISIRVQPLQVELCGGLLHRVAAVVDMALHLPPHQEPEQSLRTLTVEECEALSNNVPQRRCDVEVCGLVVRAWPWQHPPPHHRAAPPLLLDFELPLAVATISTPLYTYRVCSAACQMPEDEALVWSCARAHVTFNVNGATASVRGADTPPRPVAHADIRATSHRLLHPHLFKHYATVHNSYTFNIREAGICGSVARLTAAYEILTALRNARPSTLLINTTLVYDALHDDEMVSVDASLEQLTLRGYATLGLRTHIVSLHSVKASAIHAPKDGDIKQAWLFSGPEASTTSPYLRIAMQWETDVGAGPLEEESEQLRAVEFIGAWLEPTAVSLDPLMLAGLVYMPRVTLSSVDSQSNLITGKSVSSSLHSMLRRPTPPSSSGRGGSRAGSGAEVHTRTRSTTSSAERTELMHAPPTPRPNDTRNTLGKKAAWWWSGERAVQMHARLRRALACCELGLVQVYVPAQSVPARGSRPLRAMAGIAGLRDAVESHAVHKPVLVFSLGHLTMHSNTMVKHLWNDIRHDGPTYIAAKPELTLDSFPWRVRIADVSCYTLEARRATDGVRGALKDTRSTAPRALLGLLTTTVTLSIVTKSLSVRLPTPTQRTPHVAHDEKIKYFTSGVDFKPSTLKEFIRGPSKYTKASPEPTAAPAAGGPVVSLGVHVHADTPPITLHLDQDQVGVLADALHCLSHLALLLRRSSVSTPAPAYTPSVPAVNKSLIRSVSEQEERETPSERTPSDNRSDLIPIFEASAIKLETKTFVWVQWVISRATVAVSTGRARLAADVDDIIATVDLQPHYSQLKLKLASASLRHYRRSESDEWEAGAMGGRVLEAREPLDSKQDNHFLALTVTQAKISNLPASWREELHPKLLEQKSQGSDSMWEVYVTLAPLEAVVQASVVRLAAAVLRLLRPSTAACPLRPPTPTPTPRPLSHLATTHAPLRNEWQLPFFYMSAGGLRLLLTEHGAESAEDDTIMLVIGKVTVNPHPENPICRRVVNACAETSGWATGASAPDGRQYEALARGVALRSARFHQLVRQEVSEAEIMKGTGGENPALKWSQPTISPVITPILHSVDVECVVAPTVVVYDEEGPTVACGPALELNLASDCSVELGLHQLALLVSLSDSMRDALTHGVEDVDADEAEEESNTCPYSQLIPEPLSPWPDTAPMPPTPSSATVAPTTSANSTPASPWTTRSDSMRGGMDSGVASAASHCAAKYSLSEEPQGPIKKNVSIALANHRIDPWEHFELFVTMGVIEACLYAADTGGGELAPLRAREPPLADHVPVSAPPSATPGPATDTAPEDQSRPNVSFKDIKETSKKDDGRESATAGSSIAPDDIKSTDIDKTHFDLTNVLPQARKTEGYLQMIHISLQQPNLYYWRKETQRTFQVSLFDAGVALGGGTSRRVLLSTERGTRDPLTDIPPALATLRATIPTTSISATVIPNARGTLQLDVERPVLFDVCTDRLMRLHTIVKLVNKQLKQVKTTTEEDTTQSSMRRLRKLMTRHGVANVSLSAGQVGVRGSVGTAGWTSASAHVTAALRPDRLNARVLLRSLFACAGAPCDARRPVLLPVNVGGGGAGGGSGAAGGVRGALYADAVTLDLRPGDLEALSLLQHAVLQLQQFLKGETQDSWINVGEKKPSTSSTATVSSTSSLEDLADHYYKDDLRSGAFRLVRGGQVPMAYQVRAMAGALAWRYPHPRALTRLVAFPVPGLDEEMECVLELFDSTLMRWEPHTYFHLPTSEPREFKLDGNPAAMVFALMWRVRLSPRAEDEQTPFLFDANKFMSQHDPLGADAMWSAVSDTDCDSAGSSAGGGMGGGQLTSEQLWGSMRVDSYFAPRLLPPTRVAMRLAALSIYLHNDMPALNEENCRKLEGLYVSRPLRRSHRVLALSARDSAAHLHLGPGPSTRRCLMHAHFSSDILDCTTGTMERLVEEFRVQASVLLTPVRDSEARDWRVRTCADHVYVSLNVPHVYTLQALANDWQHAYDQYVLKEKDGVESSATEENEEAEFLEEEESQRALRGRVSLWLYNECGAALRVSQLATEELLPLGPDSMLAYRWHSPNEAKKLRFSLANPSTDWHWSNSIPFVEGKYLVRLEEPNVCLNGGGAVSDKACGADVAPGISRLAPGAGVFIYARVTEVGPTRTMRLTGRLTLANMLRHPLLYKVRVRCASTQQWRAQCAGELSPERVCPALLCETAADLSLKVKFLSHDAGWSGDIPIKECPKENVPWLVKVVTHIYVLFRNIDCPVTPKGVPLHYGITQTSVFDESQPVQDIDDVLQEINNWLREWGREARSDWPYSLVRRHWRGVWQPALLQPRTDITVQYSAVCAGGGCSLAAQLWPVMLLANAAPMPLTLRAHDAAPLCRLEPGHVVSPPSTLLTKPFFLSLEMGRETFVSEPLVVSSQEPGRYGALPTGHLALGHAAHIAIQCNHKVALFTMYLEVKEDMNVLGITSTYVLRNDMDTDIMITCIAVPEGTDDEVLLNPKSFKVIPPSKDKRCVGEALCRAWIWSRWRSGARANTFLCVSLTHDSAVPVRLATPPEHAGPAHHGAQPSRRAIALRDHNNQSVPVVVTQHHHDGRWQVVVARDPCPQFVVYNATGERLAVAQVDQPEVYNDYQQNTASDNVKAVRECEGARWMCTVGPGMSTHYTTPAYCARYPTRRDSGRGHYTPCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLB0</accession>
    <name>A0A194QLB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 22 member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLB0"/>
    <dbReference type="InParanoid" id="A0A194QLB0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="340" mass="37436" checksum="EC8B1B373A1D57C5" modified="2016-10-05" version="1">MDSVFDQALIEIGQDACDKYEYDKTWYEETVPTKNNWVCDKELYVANIFAASKVGELVGSMVFGWFGDTYGRRPAYIIALVLLVLGRVISLFAGQSFVLFVIGCVVAAFPSWSAIQSVTVISMELSSAERRSTTATLRFAVIMMSSGDKSDGNPFLEFLWQALAEVPGYFLAAWLADRIGRRNTGVLSFSISACMWIVHVLRENSSNAIFRHSLTSTAIVIVTRLSATMGYYIINILNFELYPTCIRQSGMSLGNLFSSGGSALAPYIFYLGHRVNLQLSSVILTGVSVIGVISTLLLPETLNKKLPETIEDAQVFGKNTQTYTPVLLNTSGDDPVLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMI6</accession>
    <name>A0A194QMI6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMI6"/>
    <dbReference type="InParanoid" id="A0A194QMI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="36789" checksum="CE1595CA59B92E86" modified="2016-10-05" version="1">MDPVRPNNRDMKEQIDSNQAELTNMISHNRSEQKHYCTYMCQTNRIKPSSDQERVFKGCCVRPSRELIEQVMEDEPKLVERTQGLCDNLDTTNTECLRETDLSTGYASTTTLENSEFSDEKTTDEGENPNLLHLTKMQWLTDSQTDSTDSRSSTPPISRSVSFAIPESSDSEGDMKGCVSFGEKCLSTILRLDREHNMFGLSNITIVDSKMLKKSRKDDKDPAFPQTTIIQLLCCEKKCCHKSNTDLPLSLKRVPCAKPRCLMDCNTRYGMKISLKRKPKFEPSPRGRPRNRWMDCVKDDMIKKGVTVEMTADRLIWRTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMK2</accession>
    <name>A0A194QMK2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMK2"/>
    <dbReference type="InParanoid" id="A0A194QMK2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="27709" checksum="CC3E954B1EE3A3EA" modified="2016-10-05" version="1">MDSENSPTTAFSNKVALLLCVAGIASAGNLLHGGAPLSLATYSAAPALASYAAPAVATYAAAPVVTKTIAAAPAYATYAAAPSVSYQTLSAPVATYAAAAPVVSGTYAAAAPIVTKAYAAPAYSTYTGGSAVSYQTVTRQSSPVAYAASTYAAAAPVVARTYAAPAVSYAAPAVSSYASAPLVTKAVAAPALAAYAAPAPAVSYTSIASHATPVAYASAPFVTKAYAAPVATYASAPLISKTIAPAVTYSSIAAPVAYSAAPAYSAVKTYYTAAAPVAYNHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN32</accession>
    <name>A0A194QN32_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN32"/>
    <dbReference type="InParanoid" id="A0A194QN32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="194" mass="21744" checksum="3FAABCA18DEFDF7E" modified="2016-10-05" version="1">MEEFFEKLKKKLSVDNILDLMKDGKLKEDIKQTLTGTMNLSEKPKQEEVRSADISKNMLDPKNQITVENIQHKTNEDQTPVKLSEPHNLAEENEIQKKASGSHLQAAIIELNETVNLLEVKEIKKKASKPNLTTPETTGESSPGLRESTATESIEGSSEPDKSNIKVLQKPLTMPSQAEQVESKTQFDDFLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP03</accession>
    <name>A0A194QP03_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP03"/>
    <dbReference type="InParanoid" id="A0A194QP03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="181" mass="20768" checksum="49B4EE59EAEEB4FD" modified="2016-10-05" version="1">MKASIVILLTLGNQTERGEVSTITNSIINTVQVFEDTTSTIYRLADKGKILVCISTKKAVSHMEHIFFAATCTLCIYEYDRPLVYKKNPAPDGHRCGLCPTYYQKTCGFNMQDNTTYIFDNHCIMDLYNCFEGTEFITMNYNKCLYFGNFAYVHGFKNEDKDYGEDHFIIKGSKKNPDFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPF7</accession>
    <name>A0A194QPF7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein with SprT-like domain at the N terminus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_11359</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPF7"/>
    <dbReference type="FunCoup" id="A0A194QPF7">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPF7"/>
    <dbReference type="InParanoid" id="A0A194QPF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="16">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ06860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="576" mass="65793" checksum="8ACC28BD83164053" modified="2016-10-05" version="1">MQTGNVTEQFGGIRKMNLADPELELIDPTPDVHSLFLHFDKLFFWTKLASRVAVRWSKRMYSCAGICSYDCRSHFCDIALSEPLLKLRPRKDLIETLLHEMIHAFLFVTCKDQDRDGHGPNFKEHMYRINKLAGVNITIYHDFHDEVKLYQTHWWRCNGPCQKQKPYFGVVRRSANRAPGPTDYWWSRHQKKCGGTFVKIKEPEKTKSTKAKETKQNKPKENITKYINNNKDLSNKNTLTKPSEGIKNNNNKTIIVAGNIDTSVSQVDKKLPTNKVRNSIDSRKSLQSNDVVETVRNVWTNKQLPVIKNNNIDSNDRKTNSNTKAIVNSNKQKSRDSMINSPPNKIRKIDDYFKNVVTTVLKDIYGEDFKISESEKDKKLIASKIKLVHCPICNVQIKEDEINRHLDECLNKGIIDKITKSNTKTEPTTSSEENKINVQINNIKTEPIDNNNVETPSSSDNSYIVKKPIKIEPGCSKDIDSELKHNCPCCGKTIEKSVAEHLDECLSFFDNNTKIPEEGASTSFIMETIVIDDDDDDILDETQTFNATGTKSPCPCCLKMIEQNNMNDHLDICLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSN5</accession>
    <name>A0A194QSN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B-cell CLL/lymphoma 7 protein family member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSN5"/>
    <dbReference type="FunCoup" id="A0A194QSN5">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSN5"/>
    <dbReference type="KEGG" id="pmac:106718476"/>
    <dbReference type="InParanoid" id="A0A194QSN5"/>
    <dbReference type="OMA" id="DDSNTCF"/>
    <dbReference type="OrthoDB" id="5989898at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15216" checksum="7F093CB5ABFB4FE5" modified="2016-10-05" version="1">MSRSVRAETRNRVKDDIKRVMQAVEKVRHWEKKWVTIGETTMKIYKWVPISTNEQKKKHAAKRENKENTLTPKKMHDSSNSNFGMAEDSNTCFSTVSDSQGPTEFTSSHMNFSEDSNSQSSGTTTPAKRLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTI9</accession>
    <name>A0A194QTI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTI9"/>
    <dbReference type="InParanoid" id="A0A194QTI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="194" mass="21847" checksum="03EFF8C8D38D0852" modified="2016-10-05" version="1">MLTLLHNDMEDDAERRGFYEVAYGNQLRFHEGDVISTNNQRRFANAQYLASVTVIVLYTSTILTSIYLMCSISLLHGAVKYKKEYIFPWIVAAMIDLLLLISAIIIGDGYPCVINLFNGHNMYHFTCALFVASFVYAICAVISFSMEVSAMQCARHFADERGERLLLLDHAAHSSLLSAAQLNKLSHGTRTHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTU8</accession>
    <name>A0A194QTU8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTU8"/>
    <dbReference type="FunCoup" id="A0A194QTU8">
        <property type="interactions" value="1646"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTU8"/>
    <dbReference type="KEGG" id="pmac:106719435"/>
    <dbReference type="InParanoid" id="A0A194QTU8"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="243"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="464" mass="53666" checksum="A3C3940E82CF0D4D" modified="2016-10-05" version="1">MADILDILDIEQPGTAEITRDSILHGDKMKKKYVTAKAARRPEGMHREVFALLYNDNKDLPPLLPTDTGKAYKQTKAKLGMRKVRKWVWAPFTNPARKDNAVFYHWKRKTDESKEYPFAQFNKQVSIPSYSESEYNQYLKSEDWSQAETDHLMDLCQRFDLRFIVIHDRWDRAAFRDRSVEDLKERYYNICGILSKVKTNPWSNTVTMVNGEKRVYHYDAEHERKRKEQLRRLFDRTKEQIEEEQTLLAELKKIEARKRERERKTQDLQKLISRADGNSAAANQTAITNDGMNTPSTVSSSIARRHDRKLHKKKLAAQQRPMRAIETVTVEWSGIKFPEARGTGVWLRSQRMKLPPGVGQRKTKAIEQELRLMNIDIAPTPTEAICKHFNELRSDLALALDLKNALTSYEFELQALRHQYEALNPGKTLTIPPSICNMSTEADTKPLGEIIDVVGSPGSHNNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTY8</accession>
    <name>A0A194QTY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTY8"/>
    <dbReference type="STRING" id="76193.A0A194QTY8"/>
    <dbReference type="KEGG" id="pmac:106717497"/>
    <dbReference type="InParanoid" id="A0A194QTY8"/>
    <dbReference type="OrthoDB" id="3176202at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="41512" checksum="2DA09F427B00AEDC" modified="2016-10-05" version="1">MTSLLILKSMLLASIVNKSKKKKLLKKKKIIKSEVKLKRCRICHIEKGHIPIFNNEAHPNIPEEIKHFSGVTINHDDNLPKHMCQGCLDLLNGCIKFRDMCQNNNKLQIEQSIKNEYNNYNNESNILLDCEDFCDMPSPVLSEDNSEIWDCSTCGQKFYDMISYNNHLNKCTSQVTDDPKENGQTKNKTFLCDICGKIAKSKGSLAVHRAIHENVFPYKCDECSYQGRTMDLLKVHKRSHLVDKPYKCSQCPKATTTTSNLAKHMRHVHSTNRPYKCNYCDKAFSYQHDMKRHVKDIHLRQGRVECDVCFKKFNTKKIFQGHRWKIHKIKGGKLGRIPSYLQCKEPEENGNIIMPLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTZ4</accession>
    <name>A0A194QTZ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasminogen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTZ4"/>
    <dbReference type="STRING" id="76193.A0A194QTZ4"/>
    <dbReference type="InParanoid" id="A0A194QTZ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="26858" checksum="AC3DFDB75C06D9CD" modified="2016-10-05" version="1">MLLMCLTILTTDSNRVKRIIGGVEVDCGSQIRVVSLRADSSRHLCGAVLVTKDIALTAAHCVQTPCNYVLQLSNLCDDSRQASVLEVIKHSDYDKYTRAHDIALLRIHLDTHNISWSVDNILPNTSFGLSGECIAYGYGSTDSNTEILPDRLKAANLKIISLDECTDILGLYVAPRFDYGMLCALGNGEDTCQGDSGGPLMCAGKLQGISSYGLSCAVPTVPGVYTSIGMHLPWIYHTMEIIPKETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU33</accession>
    <name>A0A194QU33_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU33"/>
    <dbReference type="FunCoup" id="A0A194QU33">
        <property type="interactions" value="1308"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU33"/>
    <dbReference type="KEGG" id="pmac:106717499"/>
    <dbReference type="InParanoid" id="A0A194QU33"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000124">
        <property type="entry name" value="STIP1 homology and U box-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="210"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="287" mass="33745" checksum="57EC4BA573D82067" modified="2016-10-05" version="1">MSKHMYSTANLTDKELKEQGNRLFSLRKFEDAMNCYTKAIIKNPSVATYFTNRALCHLKMKRWEATCNDCRRALDIDSNQVKGHFFLGQALVELDCYDEAIKHLHRASDLAKEQKLNFGDDIAAQLRIARKKRWNVQEEKRISQEIELQTYLNRLINEDMQRRIESIKVENPNEEEANTKIAKIEEECNNYSSELNNLFSKMDERRRKRDVPDYLCGKISFEILNEPVITPSGITYEKKDIEEHLERVGHFDPVTRVKLTADQLIPNFTMKEVVDAFLQENEWALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUP3</accession>
    <name>A0A194QUP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUP3"/>
    <dbReference type="STRING" id="76193.A0A194QUP3"/>
    <dbReference type="InParanoid" id="A0A194QUP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="11520" checksum="EDA948EE803DE9A4" modified="2016-10-05" version="1">MESPPSFSTHSEAPLLSEDSGLLITSGSFSSDSASGWHHITSELQESDFEEGSLSLCESTDTPERMCDDFFNTVKKNPGKPVVTPIEPPPEFQNSPKFTNIASKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUV0</accession>
    <name>A0A194QUV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUV0"/>
    <dbReference type="InParanoid" id="A0A194QUV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="240" mass="26054" checksum="04EE538CE758B0B3" modified="2016-10-05" version="1">MRRTERRQQAAATGIVHIDPPNPLRPRTRSCIRAAEASVLRGKCATRVHGVRLLDGITFRPSKLRYSNRYSVRESPSRARERVAKAAPSGRGEASPRLAAGRESGGREGRGPAAEEAGGGARPGYGYEALSAASDGSDAELDEAPEYTAFDMDMSGGAESVDGPSSRGSAKVNFPPDVGQERRATVATAATAPRRSRGRSMSAWSDISRSSIRFEERQVPFYLYILFVCIRRQIAIHLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW21</accession>
    <name>A0A194QW21_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoamide dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW21"/>
    <dbReference type="STRING" id="76193.A0A194QW21"/>
    <dbReference type="InParanoid" id="A0A194QW21"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="9">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="13931" checksum="09597BE8632981D0" modified="2016-10-05" version="1">MPVHFNYDAIPSVIYTSPEVGWVGKSEEDLKKEGRAYKVGKFPFLANSRAKTNGEPDGFVKVLADKATDVILGTHIIGPGGGELINEAVLAQEYGAAAEDVARVCHAHPTCAEALREANLAAYFGKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW82</accession>
    <name>A0A194QW82_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW82"/>
    <dbReference type="FunCoup" id="A0A194QW82">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW82"/>
    <dbReference type="KEGG" id="pmac:106718477"/>
    <dbReference type="InParanoid" id="A0A194QW82"/>
    <dbReference type="OMA" id="WGHMEMM"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="241" mass="28018" checksum="219D4850DAAB3A85" modified="2016-10-05" version="1">MLIRSIKQSLGLLRPECIQVTCNAGIKYFPPPKNYDHIEIPERPRLRMFEKVPQYPSNLKPPKMQKRLRYMRGPELLHNKLQLKQYGVVALGGGRLAHEHFEMARLVVARHLDMKRMFAIWRVDPPWQPVTKKGQGQRMGGGKGAIDHYVTPIKAGRIILEVGGKCEYAEAHHMLKIVAERLPFKAKAVSQEIMEKEEAEEKWKEENNKNPYTMKYIIQNNMGGCHKMLSPFDHKWHGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXJ1</accession>
    <name>A0A194QXJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ejaculatory bulb-specific protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXJ1"/>
    <dbReference type="KEGG" id="pmac:106716718"/>
    <dbReference type="InParanoid" id="A0A194QXJ1"/>
    <dbReference type="OrthoDB" id="6625994at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264714" evidence="1">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="14705" checksum="E6CC988F6BD8CAB7" modified="2016-10-05" version="1">MKLVILLFLVSISLSVNARASGKYTDRYDGINVGDVVSNRRLLLPYLKCLLEQGKCSPEGRELKSHIREALENYCAKCTDTQRRGTRIVIAHLINNEPAYWKQLTDKYDRQHKYVTKYEAELRTIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXK2</accession>
    <name>A0A194QXK2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXK2"/>
    <dbReference type="InParanoid" id="A0A194QXK2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="6875" checksum="23AB0EAFF58167CA" modified="2016-10-05" version="1">MPPAMAHLAHGAHVPQGAHVPHAAHVPHGQPMPHGQPMPHGSPLPAPPLPAYPYFVPNRNSVGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYE0</accession>
    <name>A0A194QYE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYE0"/>
    <dbReference type="STRING" id="76193.A0A194QYE0"/>
    <dbReference type="InParanoid" id="A0A194QYE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="356" mass="38078" checksum="E0E1A08BE0E875F9" modified="2016-10-05" version="1">MGKVATSEALRFMTDCLKAVGAASRPAQQQAELLLQADRLGHPSHGLNRLEYYINDIKTGACCPNNEPRVLKESASTAWVDANNVLGATAGHFAMDLAVSKAKDTGVGWVSVKGSNHFGIAGWWAQKAADKGLIGMAFTNTSPLLAPTRSKQSALGTNPIAVVAPAENGESFYLDMATTAVAVGKTCVKTVPNEGLWSLSTLDYGVSYVDVIEMQLRKGEPIPKWWAQGPDGKETTDAALAYETQCLMPLGGAENTSGYKGFGLSAMVELFCGILSGSLYGHHIRSWSHSGEGGAADLGQCFVALDPGCFAPGFQHRLADCMQHWRQLQPTDPNLPVLAPGDKERKNFFLENYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZN4</accession>
    <name>A0A194QZN4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_15197</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51308"/>
            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mical family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.225" evidence="4"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QZN4">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZN4"/>
    <dbReference type="InParanoid" id="A0A194QZN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <property type="term" value="F:F-actin monooxygenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="protein-methionine sulfoxide oxidase MICAL2 isoform X1"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
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        <property type="entry name" value="Rossman_Mical"/>
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        <property type="entry name" value="Znf_LIM"/>
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        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-0521">NADP</keyword>
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    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2348"/>
            <end position="2372"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="2384"/>
            <end position="2407"/>
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            <begin position="1234"/>
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            <begin position="645"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="849"/>
            <end position="945"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1181"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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            <begin position="1412"/>
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            <begin position="1625"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1906"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1955"/>
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            <begin position="2093"/>
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            <begin position="2213"/>
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            <begin position="863"/>
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        <location>
            <begin position="894"/>
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            <begin position="919"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="19">
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            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
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            <dbReference type="EMBL" id="KPJ09056.1"/>
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            <dbReference type="Proteomes" id="UP000053240"/>
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    <sequence length="2422" mass="269070" checksum="EA45307D62264C10" modified="2016-10-05" version="1">MRAQVTPPECALAAEMFDHFCSAGTMKQILALHREICNTLSLKPNRLPDFYPKIKAKLANSWKAQALFKKFDLRANHKVYGKGRICAQSKVLIIGAGPCGLRVAIECQLLGAKVVVIEKRDRISRNNVLHLWPFVIQDLRALGAKKFFGKFCAGSIDHISIRQLQCILMKVALLLGVELHEGVSFEELLEPTVGQHGERLGWRARVSPAEHPVSQYEFDALVGADGKRNTLHGFKRKEFRGKLAMAITANFINRHTEQEASVPEISGVAFIFNQKFFKELFEVTGIDLENIVYYKDDTHYFVMTAKKHSLLNKGVLLNDYAEVSRLLSVENVDRGALMRYAQEAARFSTNGSLPLKDFALNHYGEPDVALFDFTSMYAAENASIVYERQGKRLLCQLVGDSLLEPFWPTGSGCARGFLSALDAAWAVRSWGQIPAPHPLEVIAERESIYRLLAQTTPENLHRDFGAYTLDPCTRYPNLNRTAVTPHRVTSFYDCDEAVQYDAPIGTRKRRREMDISEGALISWVGCAEGDLASAVGAQALADLVRRYRPDLMPPSAPPNAVYHILQQEFGITPFSATGAVYEVPEAKLRSYLARVYLVFKGEVPHIQHKYDVFEQIKKSQQKEKHARNTTDHSVSVYSNAADLDKSTLSSRKKRRSTRSSQVSNDPAEYIRKKIGKLDLNDITQLARLIEGHDAISNEIDHSEKQKEIQEQILALFETEDSVDPRMVRDSLSQLLQGNTNTRIKQKGIKQTNLNDFFQEKKAESKPSKPRRKLKGLASDTIKVPDFSDIFKDDSADTDTTIVNVEQPKRKDLIRSCSTENEMTQKCTRSASVESRIPQARRMSEIIDPNRKRYSPSPEIPLSGRSNSIGSLESSYNTKRIAEIFDGRKNRHTPSPESRSVRSGSSGNKEMALRLQRMTDIIEGKRRDTPSPDRTKRLESIGNPEMALRRQKVADLIQGVKPREGPEPPQRRNSGDMAFRMQRASDMIEKRNAQAKVPKSVGRRKAAREIMKQRFEKSLQMLAAEPRLDFAPSADLEHDYGLQQYRASAPHFDERVKKLEKQLQHYEEGRVVGGGRAVGGGAHVARLAAELSHVNPSTATPKASKPKDLIRSVGKIEKDDWNVKEIEKKIMENRLGRPEPKAAEKVPKWDREEFLKRQRRLKEGEQYDEKWEDIDETINKFNQKVKDSGRPEQGNKRVASLATKFVKKEEPDTDKTESKDKQSKRSWRGPSAPGIQCVACGRRVFAAEGVVADGLHLHRSCFRCAVCTTVLRPGNYAMERYGNRLVCLRHAGVTVPDTVGVAESTNILTPPSKSQAVLSTPERISLELSDGAAREIDEDEWTDRNCLASETSAAGGLSDEKASSDEWTDVESEGEDEARALHSPRPSRDPVHIHDAADLAFFSYLSDDSFGYDDNSDEGAESSGNESCSRMREAREARRREVPADKRPPTDSSEVESEDESESSDDEVSSATEVSTDSEFAREECAPAPSPPAILVTEAPPPAPPPPQEYPLSRTRSAGGLATKRALELKRRYLLGEPSPPAVRKSDSTSQLDTKLEAFRSNITEFQKMLHLAPVPTSQVQPQKPVVTFRLTEDTQNKIQPMPDIIKNLHTDAPVDLLTKGDLPLCKNDWREPINEEKREPDLESDSLSDDDASNTETAPNQPVPRVEVHDEGGELIQLDSLMIINTGIDDISEKISTIAVPVEPAIISAESESSESCRDVTTLALTETELSDWAAESAVLDDCGIDEKENKRKQNPRTLSGPKLVHDAKNITAISSHVCGRSSPLDKIVYSNALDHFEFADEGDQDPSIGSPVTPRNEGYMELVDDKVEVESYYPNNDRSMNFFEQTFSERLLKPTGIDICRENLTKDFSDVIEFIDKDDSQEDSAPKEQNSSNIPEPAQIEISEKSSVENTSHSLQQNTEKTKTSEVSTPTSNKELNTVLSDVASISLSEVSSGLDKIHSETEKDKANSPVSKDSVEDISPPLAQDFSLSRDSIYNGTMNAPVSFSSSNNIRLYSPAICRSVTVPFSSSISRSGNSDSPCRSIDLSISATISSGSLSPASPSHMRDTTVKVQEIKRERDELNDIVRGLVLGRVRSGPREGKKSSRRTRVSPASNIPPPIPPPPVLPEQPSPPPPPPPPPPTYTSPPLRPRPPQMSLSVSSSLSDPELATERRRKGIMKSISNYLNRRLGPRHKWVSEPDLMSHVNQNVSLSMGGAHKSTGTLQETPPAPPPPPVPPPPACYSPPIHTHSSCRRLPGMTDIEERDAMQLWFEARWARLVAQRRARDPPAPPQHTLRHKPPDHNVRLAHLERRLSRPLSAEQQAAAVAELVQVTAQRDAHEALMAADRFMVVVGTVRGCPVTAMVVVVTAFVPRVGRGANVGHHQFGAVFGGFSFVSSMAVLGAGGLMEFFPRLSVIPVEAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0K4</accession>
    <name>A0A194R0K4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial sodium/hydrogen exchanger NHA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0K4"/>
    <dbReference type="InParanoid" id="A0A194R0K4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="78"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="502" mass="54801" checksum="00CB4D767BD3183C" modified="2016-10-05" version="1" fragment="single">FWHKLCLRCHQPDSTPSWRPSWWQKIFPFPLFPTYRQSAQQLCILLFFLLIWGIAYVEIGESVTPDGELFSMTILVIAAYLIGWLWLKVTTLPALIAMLLTGILFQNLHLVHMTDKYRKLNQDLRKVALVIILMRAGLGLDAKVLKKHYTAVLQLGLLPWIVECVAVCLSSHFFLSLPWIWGFLLGSMIASVSPAVVVPCLFRLRDSGYGVAKGIPTLLLAAAAIDDSISVAVFAIILNAMFSTGSVTYNIIVGPLSILAGIGIGSLWGAIASVIPEKGDTYVVPLRFLILFLGGLFSLFMSNLIGWSGAGPLAIVSSGFVAAFFWEKQGWVVNKNPVSNIFRILWIFFEPILFAFTGAQITISSLDPEVIKMGAICLVSCLILRMIATFFVSFGCGLNKREKLFIGVTWLAKATVQAALGPAALDLVRSGQTSGLSPIDEEKYAKTILAMSVLSVVLSAPLGAILIAITGPKLLSRETESKAPERNEGNVESARIAAITPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2Q2</accession>
    <name>A0A194R2Q2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED8</name>
        <name evidence="10" type="ORF">RR48_06438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2Q2"/>
    <dbReference type="FunCoup" id="A0A194R2Q2">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2Q2"/>
    <dbReference type="GeneID" id="106714081"/>
    <dbReference type="KEGG" id="pmac:106714081"/>
    <dbReference type="CTD" id="112950"/>
    <dbReference type="InParanoid" id="A0A194R2Q2"/>
    <dbReference type="OMA" id="FKLEHEY"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="26989" checksum="233661F2B5642C78" modified="2016-10-05" version="1">MQREEKQLEATLHAILNRVNDLKTAIQALISKLENEYETINWPTFLDNYAILSGHLTGLSKILQSEVAPSLRSVVVLPLQLGCERDEALARLTEGRVPACTHDLVPDLLRTKPEPQAEQRLQQFNHKASTLSHDTAQKQVAQFTKVISHVWEIISKGREDWEGESMRSAGMQPTHSIADTHALVTAVGTGKGLRPGMPSMGPSGVGAPGLGPSRGPAPQLGPSAAAMPKAPSAIKTNIKAANQIHPYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3N0</accession>
    <name>A0A194R3N0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3N0"/>
    <dbReference type="InParanoid" id="A0A194R3N0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="297" mass="31830" checksum="395B28AE33161934" modified="2016-10-05" version="1">MLCYLCAVSESVVSRSLALGAPTPPPHSPYSPLPLDLLACSQRLLIDKEGNKMEDGKLGKACLPELCCPGDRADGHVLQPLTIKTEQAKRTCNTCLTNSPKKVVQAEGGCSRTNPVTWLGVGQNVHVQVKREPHHMHVSELVAVKLEQASPGTKPDQPMPAIPASLNNGSIPVGIAVARQRVGDAGLLAALSQKDNQRLHDIDKILPEPRDPGWRGPRECSPITGAAPLVQAVTILSSFYLGLTGGHLASDKPFSSARVILGDQKLGGVTSRRRVTIRYECERDGARLECNGQTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3P3</accession>
    <name>A0A194R3P3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating signal cointegrator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3P3"/>
    <dbReference type="FunCoup" id="A0A194R3P3">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3P3"/>
    <dbReference type="InParanoid" id="A0A194R3P3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000006">
        <property type="entry name" value="Putative_zinc_finger_motif_-_C2HC5-type /ASCH_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056994">
        <property type="entry name" value="TRI4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23135">
        <property type="entry name" value="TRI4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="534"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="684" mass="76584" checksum="13D208481547AE1E" modified="2016-10-05" version="1">MDQWIKEGLSRILDFQIPEDLINYINSIENENDLNEYMKTLLDFDNSQHKSFFLELCKKKFPNKSNTITRPQKKKISKNKQQQDFLSAEVPAPQVTQAPEAENKAKKKTKYVNLYSQEGKNAQVVLLKGNTITRQQKKKILKNKQQQDLSAEVPAPQVTQAPEAENKAKKKTKYVNLYSQEGKNAQVVLLKGRHHCDCQASKHELINNCLQCGRVVCKQEGSGPCLFCGNLVCTPEEQKEINAKTKASAKLVESLMERNRPKGWEAAVSHRNRLLEYDRTSERRTRVTDDDSDYFSASSVWLSAAERDKLAKYQQALHDKKHASRLTKKMTFDFAGRQVIEDNTIDYEVDEEKVRQMTSGSAASGGSGAHLLAQGLLTDTDRDVAPGVNAPLLQRDKLAKYQQTLHDKKHASRLTKKMTFDFAGRQVIEDNTIDYEVDEEKVRQMTSGSAASGGSGAHLLAQGLLTDTDRDVAPGVNAPLLQFDESVEYGGGGGGGGYSSAVRGGQQGPGQCLGQGGRVQDAELQEMSDTGRCLSMHQPWASLLVEGIKLHEGRTWYTHHRGRLWIAATAKPPDQDVVRAIENQYRVLYPDKQIKFPTFYPTGCLLGCVHVDDCLPQEEYEKLYPDGESDSPYVFICSNPISLRLRFPIKGQHKIYSLEKSIHQAAVKCMQKMSKLQAIEANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6A3</accession>
    <name>A0A194R6A3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6A3"/>
    <dbReference type="STRING" id="76193.A0A194R6A3"/>
    <dbReference type="KEGG" id="pmac:106712868"/>
    <dbReference type="InParanoid" id="A0A194R6A3"/>
    <dbReference type="OrthoDB" id="6619754at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="459" mass="50415" checksum="100D32910FCA65F4" modified="2016-10-05" version="1">MSPGERAAPGRREPARPQYAATAPGFPPQYYPPYGVPHPNAWLGAPLISMAGRTPPSRCTPVSKLAMHAQGAPLIIQNRHDRRKYTTVPEQRNHRPSGHTDHITRDRCETLDNRQRNQQQQTRSVRSGRNNNTDAVSVASDESSGSTNSETMLPRIIKPRKRRKKDRKPNNIAPHDMTTVPLDIGDVGHCAVSSMSPGSHGLYEESYCRDISMQYRLDVKVLEYSEPAPETYRVSALGEALEATRFGLVEAASPSESAVSSCQCRYCDPVGQIWDADSIADLLDENSSGDFAPTKLEDSMKVVGPLGRRGADTILRRSWSDPSSRAPERRDASTGDLLTSSNLYSLFPPSRRASSPESRSPLALEISSEIVTSLNGQRDLEIKLFSTSPPATNSDRRSFFDDKSESDVNSCRIAGYEFKHSSAVDSERAVSSVRASEGRNDTEDIGSPRNICDLAIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7K2</accession>
    <name>A0A194R7K2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-interacting protein kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7K2"/>
    <dbReference type="STRING" id="76193.A0A194R7K2"/>
    <dbReference type="InParanoid" id="A0A194R7K2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="715" mass="74428" checksum="A816174765477438" modified="2016-10-05" version="1">MDLSLPRIKYEAEEYYDDEFELLEADLVGDSSDHLADGSGQGVCVGAAGGAGEVAGGSGRHRAAAVATTTAHSKQLAAGGPNHPPQPQVSSVISAYVTWVVPFVLACGDVDAGSGCGGDGDYQLVQHEVLYSSSNRYEVLEFLGRGTFGQVVKCWKKGTNEIVAIKILKNHPSYARQGQIEVCRRSGSGVGGVGGVGGAAEYGVGVGVGSVVAPAPAPAPHHLALTINQQRLRAAPYDNLYQLYQGGRVAVGGARQYATRAAEPFPHQFVSSILCQPAYQVQQLAAAAAAAAAAHHQHGVGVGVGGVGVGVGGVGVGDVGEWRAPLIVEPAPLPDADVWDFHPHHPQHHHPPKRVQSGGVSGTWEGGAAAGGCGAHTITIRDTPSPAVSVITISDSEDEEASRRPRPAHHNTQQHQQQHSHNNRGSGECAATTATSAHNNTNNNTAASSGGVICSARTPRDDRHVKHEPHQHQQHQTNSCHHHNQQQLQQQQQQQQSSARSQQSTAAQSVQSAQSAQSTQSAQPTPQSQKKRLLALAQQEAQAKQELLPEHQPTHYISTGGCRDYLPATSGAISAVSAVNAHAVGVGVGGVGVGSVGPPAAHKHAAAHAWHHHPHAHYKTGSGGVLSPGGPGGGVSPGYLPPPPLYVPTYHYHTGGVTGPPPAHHGSGARLPGYLQPYSPTYLVPPHAPHPAHPAHPAHPAHATHAPHQQHLWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8N4</accession>
    <name>A0A194R8N4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcyclin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8N4"/>
    <dbReference type="FunCoup" id="A0A194R8N4">
        <property type="interactions" value="2035"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8N4"/>
    <dbReference type="KEGG" id="pmac:106712136"/>
    <dbReference type="InParanoid" id="A0A194R8N4"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015120">
        <property type="entry name" value="Siah-Interact_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09032">
        <property type="entry name" value="Siah-Interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="11">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="10">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ13864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="27348" checksum="FE875F5E58190275" modified="2016-10-05" version="1">MSESKINELKGDIDELNLLLKQAKRKRVQDLLSVEVRKLETEWISLRDSASSATPMDVSPIPTTSTVQEKRYQVKLNGYGWDQSDKYIKVFVTLKNVQNLPKEQVYCKLTDKSMELIVENLDNKDYTLVINKLLEPINVGESHWKQKTDMVVIFLAKQNPMSKWSHMTEIERKFEDQRSNRFKNDDLDKKDPQESIMSLMKNMYETGDDEMKRMISKAWYEGQQKKKDSTIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8U8</accession>
    <name>A0A194R8U8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase 1, isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8U8"/>
    <dbReference type="FunCoup" id="A0A194R8U8">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8U8"/>
    <dbReference type="KEGG" id="pmac:106711700"/>
    <dbReference type="InParanoid" id="A0A194R8U8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="24515" checksum="34892ED49080797E" modified="2016-10-05" version="1">MPIDFYYSKASAPCRFVELVAAALKVPLNHKQVNLMAGEHMRPEYIKINPQHNVPTIVDDGFVLWESRAIGRYLVNKYGGDSSLYPKDPKARAVVDQRLDFDIGTLYARFSQYFYPQILEGQPANEGLLKKLHDALALLNTFLEKNKYAAGEELTLADLSLVANVSTIDAVGISIAEYPNILRWFDLVKKTAPDYEEANGKGAQEYKEIIQKMRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9A7</accession>
    <name>A0A194R9A7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9A7"/>
    <dbReference type="InParanoid" id="A0A194R9A7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="514" mass="58605" checksum="5694BEA0A45E1CF3" modified="2016-10-05" version="1">MTDKEYETYEYLPEGNEVDQFFLVQDDGSFLSLNNRQVQYMTQGQDVKENVSHVQPCAVYDVSSPQFLIDVNNSAEVISVPDQFMLPNGQNIIIANNYLLPEQNINEEQITLSDEQFHVLEQKGWILLETNDKVYVLDTLGLHDITTNDKLIQKLKCSEGSNECIQEEISLSRQQDNISLDIDGDVKLSEDIIEDHGTFFMNSNHDDQYVESMEISSLDATNENDNSVKVQVIEAQNNTEQSNTSENIPNKIVLGETKNGKKLYAKITKLNNIDSPLKQHPPRYMKRVLRNKVNCKDNIKEKKLSTLRIFFVVSMQDEKGAYSSGGQPSLVTGRVTADSGRHCFLHVPDMLHTIMNKTLSYYYSLVHTFWFTEDYKPEIKKGDILGTHFEDNCVLHVHVNEIKRADNVLRVSITLNTRKLPTKETSEDNKRKLSGKAFACRICAEIFKTEDELKQHQQTLCLHNLDVDGDLSIDLDKMAAGYSTVIENGKDKIYHCNQCKYCIALANYFGGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAJ2</accession>
    <name>A0A194RAJ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related C3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAJ2"/>
    <dbReference type="SMR" id="A0A194RAJ2"/>
    <dbReference type="FunCoup" id="A0A194RAJ2">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAJ2"/>
    <dbReference type="KEGG" id="pmac:106711447"/>
    <dbReference type="InParanoid" id="A0A194RAJ2"/>
    <dbReference type="OMA" id="DNVASKW"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="21864" checksum="AA15F6ACF18D5B48" modified="2016-10-05" version="1">MSSGRPIKCVVVGDGTVGKTCMLISYTTDSFPGEYVPTVFDNYSAPMVVDGVAVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSVTSPSSYENVTSKWYPEIKHHCPDAPIILVGTKIDLRDDRETLSLLSEQGMSPLKREQGQKLANKIRAVKYMECSALTQRGLKQVFDEAVRAVLRPEPQKRHQRKCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBA9</accession>
    <name>A0A194RBA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and KH domain-containing protein mask</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBA9"/>
    <dbReference type="STRING" id="76193.A0A194RBA9"/>
    <dbReference type="InParanoid" id="A0A194RBA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000156">
        <property type="entry name" value="ankyrin repeat and KH domain-containing protein 1-like isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000012">
        <property type="entry name" value="ankyrin repeat domain-containing protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000055">
        <property type="entry name" value="ankyrin repeat domain-containing protein 17 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="992" mass="110494" checksum="3D1EFBDCD5EDF7FC" modified="2016-10-05" version="1">MEISCLFPCVSFSYKREEYTGVTTIHPPATPPYPPPQHLFPVQQLATNLNQQHLQQQQLQQQQQLAHQQQLHQQQHLQQQQHMQQQQQLQQHQQMQQHQQQQLQQQQLQQQQQLQHHQLQHQQKKQQQHQQQQQQFTQEQQRPEHYLPQQQPQQQVGEAGGGCVEARELSAVLQYLQREVPSLVALPPHELRSLVLQVMQQKSHEILANKCVAEPCTEVSETGTERPTDCQLHAIESADDPEWAPRHDRQEPQQQQQQAQQQLQPKQKLQQQKQQQLQQQQHLQQQQQQHHQQLQQLHQQQQLQHQQQLQHHLQQQFQQHQHQHQHQHQHQHQHLHQHHRHHHHHADMTQVNTGCQYRVRPPSPAGGAVGAMGAAGVPAGVEDAAHHDLQPYFALPPTTNLPYEDHRSFANANANAGVGAGAVAGAAGGVVAVPAAQQHAKRDAPPHHPNNAVAIKKKGRLSGVRGSRADSFGGGAGAGTVATAQPAPVAYSAMDVDGETDSNHDTALTLACAGGHEDLVELLLARGADIEHRDKKGFTPLILAATAGHEKIVEVLLNHGADIEAQSERTKDTPLSLACSGGRYEVVELILSRGANKEHRNVSDYTPLSLAASGGYVNIIRLLLHHQAEINSRTGSKLGISPLMLAAMNGHTAAVRLLLDCGSDINAQIETNRNTALTLACFQGRHEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYVEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHTKFVELLLQRRAAVEVKNKKGNSPLWLAANGGHLAVVEMLYAAGADIDSQDNRKVSCLMAAFRKGHTKVVKWMVGVVTQFPSDQEMTRYICTISDKEVLEKCQECVRVIRAAKETQAARANQNATILLEELDAERCREESRRLAAARRRERKKKKKMEKKEERRKLQEENDKNSLYCDKALGECSEGGEPDDEPATKEEGDSGIDANSQGSCSSSDVKAPPAPSNKTKKKKKEDMFFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCT3</accession>
    <name>A0A194RCT3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional enhancer factor TEF-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCT3"/>
    <dbReference type="FunCoup" id="A0A194RCT3">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCT3"/>
    <dbReference type="InParanoid" id="A0A194RCT3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000005">
        <property type="entry name" value="Transcription enhancer factor-like protein egl-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="62"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="62"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="596" mass="66593" checksum="96318A516B171972" modified="2016-10-05" version="1">MKVSPELHVVRGQGARRAAGAPGGLNYAKNAQLVSERACKGPATERTQSNKNLSVTKAVMENNREAKLWRSTRDWERSRRDPGPLRAARNVSTMQTISRVMSIDEGEGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVDGGVMKDKAMQSMSTLSSAQIVAGLPHPAYHTVRGMPLSYLPVNRTRLPILVKPFPGAGYKGVGLGPGVGVGVGGAADVAPPPWEGRAIATHKLRLVEFSAFQFWQPGLQAGTSQDVKPFPGAGYKGVGLGPGVGVGVGGAADVAPPPWEGRAIATHKLRLVEFSAFVEHPRDADTYPPSTAPAQHLFVHIGGTVTYADPLLESVDVQQINDKFPEKKGGLKELYEKGPRNAFFLVKYESNENMTIMCSTKVCSFGKQVVEKVETEYARFEGGRFVYRIQRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQVPFSAYELLNDFYLKYESNENMTIMCSTKVCSFGKQVVEKVETEYARFEGGRFVYRIQRSPMCEYMVNFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCAAFVFEVSNSEHGAQHHIYRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDX7</accession>
    <name>A0A194RDX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDX7"/>
    <dbReference type="STRING" id="76193.A0A194RDX7"/>
    <dbReference type="InParanoid" id="A0A194RDX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="536" mass="58421" checksum="25747C184F79874F" modified="2016-10-05" version="1">MLPRTSSSRRRRASRSAATSPQTRSPRPSAQPSRRASLATTETDDETEPIPQRSPRASLAPDAALDMYHRSPRHSLVPETRSARNSIVPDTASQIRNTLAPTRNNLGVDLAYGSRLSLNPQDFNRSPRNSITPDVTARSPRRSLVPDGTSWNQPRNSLVPDVGRSPRHSVACIQIDPARSQKELGPSPRTSPRGSIGQDTAFKSNECSDFVRTPRGSLIPECQRSPRGSIAPSERSARGSLVAGELDASKVSPRGSLTLTFQEPLVSKERRPSEESQCAATRGRSVSPYRASLSGRHSGTGALSDTGSRRASSSVSQVSGDEQRRLCGEQAKYSERSGMGLGVGLTTYGSVAYQLKDANMEASSTVDFVCRAAKIMNRTILMTVFLAILSALPVIMLIMGVQYIRDCPAEPRIPVYMIVGGAAGGAGICWLLWAQLVSRTSNSPASVPERVLAYTLTVFLMGWFAFGNYWTLGILWPDYAPTLFEPNQWCHRTLYVFAIAQLAVVWGIILLIFLLLLTLVICQVFGCGWLGPARYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REP9</accession>
    <name>A0A194REP9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REP9"/>
    <dbReference type="FunCoup" id="A0A194REP9">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194REP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="22725" checksum="E5A646EDEA74CCC3" modified="2016-10-05" version="1">MGGCIGLTRSRSGPMEGSSGTVSRPNSGALRKNQSLCHETIRWKSDVPLTEGQLRSKRDEFWDTAPAFEGRKEIWDALRAAAVAAEAMDFQLAQAILDGASVSVPNGYLTECYDEWGTRYQVPIYCLSPPINMVKEACGRDSPAEWSEPADGGAALALRLRLSTTCRDLELRVGARHTIAHCKTELHALEGIEPRRQRWVYELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGK2</accession>
    <name>A0A194RGK2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium voltage-gated channel subfamily KQT member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_10316</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGK2"/>
    <dbReference type="FunCoup" id="A0A194RGK2">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGK2"/>
    <dbReference type="InParanoid" id="A0A194RGK2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KCHANNEL"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="7" id="KW-0630">Potassium</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
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            <begin position="39"/>
            <end position="58"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="17">
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            <begin position="571"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="671"/>
            <end position="707"/>
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    </feature>
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        <location>
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            <end position="853"/>
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    </feature>
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        <location>
            <begin position="639"/>
            <end position="666"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="780"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="868" mass="96708" checksum="DFA7DC63671825E4" modified="2016-10-05" version="1">MSLLGKPLNYRATRRDARYRRLQSKFYNFLERPRGFKAVLYHMIVFLMVFMCLSLSVFSTIEEYEAKAGIVLFYMETVVVVWFAIEFILRLWSSGCRSRYQGSIGRLKFLKRPFCIIDVTTIMASLVVLGMGSSGQVFAASALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTLYIGFLGLIFASFLVYLAEKDVADTKFKNFAEALWWGVITLCTVGYGDMVPQTWQGKFIASFCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQALWRCYAADEHSMSVATWKIHQIPLPSPQTSRVMSASFKNNASFVSRLPTIRRHKSTSLHSPAPVPAPHAKHRYDVNASAENLVLVSFSVADDSWLPAYVRDRCTPHSPIPQQQNFLGARIGRIDRCNTTTTQKTGVKWKQFRFSYDECGTGGLILVLLGNGFGGRGDALEGEISYFCASTSPLIKGASRPPGGRVVRARPVNPSHSEDSVAETALSKRNSDDEDEEPRCVTLTPRHKAAIRFIRKMKYFVARRKFKEALKPYDVKDVIEQYSAGHVDLLGRLKYFVARKRFREALKPYDVKDVIEQYSSGHADLLNRTKNLQYRLDQILGKQGSKAKDVYASKISLASRVVKIERQVDDIESKLDHLLEMYEEDRRATRRLGAANGEGGGGPGESAGRARPAIADKQCSEPNSPVSRAFEPATAPTALAAPHLKRPMNRGYSDLGTRFMRKKVIVKTSSSNRNGESPRDDEVVIVVPTDREDTPPRLATDSSEVCASCSVEVETEAEAGGTRSGSSGSPSWCEGEGEGEAGDERGYGSGDSLAEDAALLGATQPSHPPRLLRTQRRDVAVDLHLLRPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGX1</accession>
    <name>A0A194RGX1_PAPMA</name>
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        <submittedName>
            <fullName evidence="6">Integral membrane protein GPR155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13693</name>
    </gene>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="326"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ16837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="385" mass="42562" checksum="8E06FE9200ED53E5" modified="2016-10-05" version="1">MDCLERSPFANLQRCRCVCCFVCCGLETLYCYCDIVTSKMFLELGSAFLINIIMQLEVAEAASERLYPALFQCFTVIISGYIAGRLNVVTKAESKGIATFVGTFALPSLIFLSLAQLDFSIVNWTFLFSMLLAKGVVFFGVVLVTILVTKPMNLGQAGMFAIFCTQSNDFALGYPIINAIYEKTHPEYALYLYLMAPISLAILNPFAFVLLEINKQRQNTDQSDSAQNQKKYVMRIKMLLQILKGIVFNPVLVMTVLGIIGNIAFKHKLSIYIEGLLEVYGQAFSASALFLLGLRMVGQVHRLRGPALIVPCVLIMVKLVILPVVMRECVSALNAGENQTETSSLSPRTCSVVRVGGEVNSDVARPRVVDRGTPRHFCRGRAKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH60</accession>
    <name>A0A194RH60_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_09298</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH60"/>
    <dbReference type="FunCoup" id="A0A194RH60">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH60"/>
    <dbReference type="InParanoid" id="A0A194RH60"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000239">
        <property type="entry name" value="Transmembrane and TPR repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000528">
        <property type="entry name" value="Transmembrane and TPR repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="19">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="817"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="865" mass="96055" checksum="81D0765F4D7A5A05" modified="2016-10-05" version="1">MLYGFVPLKVSYRRCQGKSGARDGQGNAEALEQSHKSYRPLTVLTFRWNYAVHGLQPAGYHLVNVLLHALVSLLYYRVCAMFLPEFASFVAAILFAVHPIHTEAVTGVVGRAEMLSSVFFLGALLCYARAASRRRYTGKVTGVVGRAEMLSSVFFLGALLCYARAASRRRYTDWRYLVACTGCVGIAMLCKEQGITVTAVCVVYELFVAQKRRGLVLNGRSWLEAWGKAGWGCGCGEAARRVATVCCATLALLAARLHVMGAQLPVFTRFDNPAGASPPPARHLTFAYLPALNAWLLTLPEALCCDWTMGTVALLRSWRDPRNLATVALATLLIAAAVHALRTRSSALSMGLALLVLPFLPASNLFFPVGFVVAERVLYMPSMGWCLLVAHGWRLLARRRASLAAAALIFLLLAFSAKTYVRNWDWKTEYSIFASGLKVNRNNAKLYNNVGHALEAEGKYAEALEFFNTAVSVQPDDVGAHINVGRTYNHLGRYQEAEEAYVKAKSLLPKAKPGESYQARIAPNHLNVFLNLANLISKNVTRLEEADMLYRQAISMRADYTQAYINRGDILIKLNRTKEAQEVYERALLYDSGNPDIYYNLGVVLLEQGKASQALAYLDKALELEPEHEQALLNSAILLQELGAADLRHLARQRLLKLLDKDATNERVHFNLGMVCMDEGDAACAERWFRAAVRLKPDFRSALFNLALLLADRRRPLEAAPFLKQLVRHHPDHVKALVLLGDIYINSVKDLDAAESCYRRILELEPDNVQALHNLCVVAVERGKLAVAEECLSRAAALAPHEHYIQRHLAVVRTRRAALASPTPHTPHTPHTTHTPHAPPSASEVRARWNYIPQQPPDPHETDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RII3</accession>
    <name>A0A194RII3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPPDE peptidase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RII3"/>
    <dbReference type="FunCoup" id="A0A194RII3">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RII3"/>
    <dbReference type="InParanoid" id="A0A194RII3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21626" checksum="89ABE34878A095FB" modified="2016-10-05" version="1">MFPSCMSLLPRRSEPRPPRPGQAPVLLNVYDMYWTNWYTAGAGVGVFHSGVQVHGSEWAYGGHPYAFTGVFEIAPRDERELGEQFRFRQSVHIGYTDFSEEEVRRLVTELGKQFRGDRYHLMNNNCNHFTSAFCLALCERDIPAWVNRLAYRVADAGGAAALAGGTLSLIFTKHTTIAPSRARRRHRECCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJT6</accession>
    <name>A0A194RJT6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJT6"/>
    <dbReference type="STRING" id="76193.A0A194RJT6"/>
    <dbReference type="InParanoid" id="A0A194RJT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="8629" checksum="3B42FF2492E7042E" modified="2016-10-05" version="1">MARYFENTTTFNFSWDQVACGYWKRYPNPQRFFNAKSVKIIEESIVDPKEKVLVTYTRNLGYTKVMVSFPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKM4</accession>
    <name>A0A194RKM4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKM4"/>
    <dbReference type="InParanoid" id="A0A194RKM4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032073">
        <property type="entry name" value="FNDC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21104">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21104:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16066">
        <property type="entry name" value="DUF4808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III" evidence="3">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="26372" checksum="3E00384EB8583B89" modified="2016-10-05" version="1" fragment="single">AEWSGATGGPPAEVVLRLHPTDSPPPPPPTGNFSLLEVEDGGVVVRAEEALIVSFVLLLWAAAIALFFNRWGKIRMLEPYQPKFQQQHRQSCVLTENSVSVPPHHRASMSRACMSYDYGPSFTSYQPYAYLSHRPRQNSVFVGSVGGGMALIPESPPRRSRSAADLPALVTPADLSHTTPRSSRAASLHSAVDLRVCVPSPRTSRAASLHSGDMHSSVQVHVRGSGNNLNRPKSPRRLTITNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKU3</accession>
    <name>A0A194RKU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKU3"/>
    <dbReference type="InParanoid" id="A0A194RKU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="479" mass="54015" checksum="B14336BC344D3C29" modified="2016-10-05" version="1">MTVGEYCRHFESYLAALRVVLCSTPEHRNDSPSRDSDSLCDSDSASPVPFLCTQDGTEGETDVIWNHYTPKSGNRAHVKNTTPLSRRSKKSLRPKVLEKPLPRRRAIRPSKKKSALLQELLELNQNLNEIIGNKPEKTSIPERDDSEDDIFRDIQEFSPKSGLRSNTCLRKNLLSSRFSKPEPEVGLDSDDSMNECLLKATQVVEENLFKDDNIQPKVDVPGNKTKCMNSSFFKIDQDSMDAILHSIKFDSPSAKRVKKCNSPQLVNDSFDGFVGNLNNSALERLTQMPTKTRSPGHESKTEKSNELQLDFNGSFSKTSFSRHSSMPESPSIAQLNKPSTSGMAFGRYSSMPMDKNQMDPSDSPIRCTPDEIKKKHQMAREKLLAKRQLPFTSLPCSNALPSIPEQTSLNKYKFQPKVPSEKAFIHTKLSNIVNKPNCTNPPLSNQRSNTEIDIKAIIEKKRQEALMKLRLRKQTQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL50</accession>
    <name>A0A194RL50_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative epidermal cell surface receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RL50">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL50"/>
    <dbReference type="InParanoid" id="A0A194RL50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF34">
        <property type="entry name" value="EPIDERMAL CELL SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265298" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1551" mass="173675" checksum="CBFDA3FAC2E54F59" modified="2016-10-05" version="1">MAWTVRAVALWCAVVLALLTTTAAYTVDCNHEYTDCDTELMTGVDVTSEGIEWQNVNTETSTENDVKSNMTEISRTIQSENITTTGVDTKQVNTLEMTEPYLVVTKHETVSLGADTTFTEWMTSLETSTVISTESYTVPSTEPSTDIYSTVKSSMFLKQTNIPTTTGKMTTDEEEVSQHQPSHLTIPPFVFTTTPQPKKIFTETPTTTTTITPSPPKSTVVTPTTDSKIDLETTEMTYLTDSILKAKPRLLDLSVDELQSFANALHNQTNQGMNRKLSDISEVSLDVDEDDEPPRLITSVPKNKDITDKFYSNLQVPFNPLLSIDKSDEVEICKENEIIYKVGDRIDRGCDETCECTTSGIFECSPRCKHPYTRRGRRLNDPLCFESPVDECCSIIACSTGTGATKADACKFKNESYAIGSSWNIGCQQTCVCEEHSVVSCRPRCNRLQTSEKCINVQDPNDDCCEIQVCDVSSDAHEEPENITMTTTTTITTSPITTPMTTTTSTTTTTSTMISSFLASETGRSLDDVNDSFRPTMRPLVLTEPIGSVTVLQNNSVQVNLMHMNNSEDPIHLLLSSDGGRTFRDVELRYTNLILNLEGGKDYILKTKETGTKFNFTITTTDSTSNEVPVEESNTYKIGCHQDGKFYAVGEEFHIGCSELCECTGDEKRECAALVCPSHVGLELVSKGCVRWAANPPAHPPNCCPRTARCLSDGTCHYKGVPVPNWSEVPLTLTGCEQRCFCENGELDCQEVCSPLPSLPPQNLRCPPNHRPAAVNISDEDCCKQWGCIPNAAYKNGSKYSHVFSSHDASQNHVTPVAPVLPTVTTPVLPTPLAMTETNDYFRHMNSAKTRQKTNKLVQPPDPGPIADDSLYHYHVHETKNNTFAIYSPNEFHRPFKLLQPIPPVTSINVNWKSLEPPNNSVLVAPVPVSIQSNIPIASHHSDTGTNTRNHLTYVLPDNKIQDLFEKYKHNQMMEAKSISDHDEYVQQMHESVSKVPLLQMHNLNYFLPVYDKKIPSHVPFSFGETKTTPGSTKPTKTYFEPMFNQSADYYRKHPNPQTYKNGRHDVHGLHGKHVTILRSKDLKPIRPSDSGNNDKSWPPNNIHVLAKVPNPYETVLFRVLPEPITDMQKVPSNSVKLNKVSGKSYSTLDLEHMLSQMEVESEVNRNLGRSADKDIGEHAAGPMPGFPGKPHPPEFIPTIPPDVRYPQEEIVDYEQNNIHRPLNLDPTLNGIPMPPSYSDDNKKLSVILLQSDTPTSVKMIFGLPPVLDISHWYSQIFAPADEILGTQRLDFRLTGLKPSTTYKIRGKLYLHNLPVEPESDVFNVRTLDLPTVQAEEEKRREINSRLTVVDVNDTTARLSWRHFTDDELQFIDGIQVRYRPVGTNKVMSIQSNVLDPYNWSVTVEVHTVGSVAAELMWHGVPAPAERWVRIYRAAHACGSSRKEHDDFRLATRDLPPTVTLNGLTPNSKCRVWLELYLTNGKVKTSNVVEIHTKSENSPETVDSKYLVFYGHYNYDKPSIEYQYAFRSLTVKFPWAPGQWAQRDRSQRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL59</accession>
    <name>A0A194RL59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL59"/>
    <dbReference type="InParanoid" id="A0A194RL59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="77" mass="8727" checksum="9A8A5CBE12F619FB" modified="2016-10-05" version="1">MFFFNSRFVKDLEDGFVRHRPTARLRQSASMGATSSASYNEVIPPPLPPPPVALTQGRRVDSSLKRLERAHDDLFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLJ7</accession>
    <name>A0A194RLJ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">39S ribosomal protein L37, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLJ7"/>
    <dbReference type="FunCoup" id="A0A194RLJ7">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLJ7"/>
    <dbReference type="KEGG" id="pmac:106721683"/>
    <dbReference type="InParanoid" id="A0A194RLJ7"/>
    <dbReference type="OrthoDB" id="5835618at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="412" mass="47622" checksum="2D66C6FE90F732DC" modified="2016-10-05" version="1">MKLSRVLNRQHIDFMFKKHWLVQGKRVPIDTGVEDVLREKGIPVEDALEFIKEKPGPRERINIVGPYEPQLPLDETHPDYKTRPCLTLTNKTVLLEGIAQAQVLTKTIIAENKLPNKIEELAEITVPKAVHEGVKKAILSSNVFDCEQQKLPKIKDPVRPAYNFPRILGITDRRRNQIITNKLLQLIERCSDFELTQTRYALNDVECKTVFDKDDDLIQFQDVSNILVTSTSPLKHDIMNEKNIPFVEIPDLYPIKHTVTLPPEHFYDEKSIYPIEFNVSRKHPHTTWLHFNRTEVNNIYETPVTDTQIYGRALTHAFTVASAYAKELHGEGVQDLSEPIYVNCIQTDGQKYHFGVFELNTLNVDGIEGTKNVWYCKNDLKLYDRSCYFNGMPVLENYNPKVYGYINAFYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLM5</accession>
    <name>A0A194RLM5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">succinate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_10682</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLM5"/>
    <dbReference type="STRING" id="76193.A0A194RLM5"/>
    <dbReference type="InParanoid" id="A0A194RLM5"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="16" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="14">
        <location>
            <begin position="55"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="15">
        <location>
            <begin position="366"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630664-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="518" mass="57233" checksum="D8E6AC751CD28600" modified="2016-10-05" version="1">MSALLKVATSRSPASLATYLYRNLHLSVGGARAAKDESVNTNTSKAYNVIDHQHDALVIGAGGAGLRAAFGLVQEGFKTAVVTKLFPTRSHTVAAQGGINAALGNMEDDSWLWHMYDTVKGSDWLGDQDAIHYMTREAPHAVIELDNYGMPFSRTPEGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLRYDCEYFIEYFALDLLMEDGVCKGCIALNLEDGTLHRFQAKNTILATGGTGRSYFSCTSAHTCTGDGTAMAARAGLQNEDMEFVQFHPTGIYGAGCLMTEGCRGEGGFLVNAKGERFMERYAPVAKDLASRDVVSRAMTTTGEASIANLDKIRYANGSISTADLRLRMQRCMQKNAAVFRQKSTLEEGQRQIHEIYKQMKDVRVSDRSLIWNSDLVETLELQNLLLNSVQIVEGALAREESRGAHAREDFKTRRDEYDYSKPLDGQTKLPFEQHWRKHTLAETDPETGATSLSYRPVIDSTLDQRECSTVPPVNRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMM1</accession>
    <name>A0A194RMM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate--CoA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMM1"/>
    <dbReference type="STRING" id="76193.A0A194RMM1"/>
    <dbReference type="InParanoid" id="A0A194RMM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="446" mass="48957" checksum="F57B7277E2B8C6BE" modified="2016-10-05" version="1">MASVLKQRGLQLKKQMQVLLSQSIKLSSVKNEPYILKSVYEDIPPVNCTINDFVWQNLDRWPDKTAVVCAATGHGYTYAQTHRMSISFAASLRTKLKLKNDDTVAIILPNVPEYPCTILGVLEAGCIASMMNPAYTALILIDNDGLPEGVIKFAEFAEDMSIDTDCLKSVQRSKKDIAILPFSSGTTGFAKAVVLTHQSVVAMNQMINNPEIIAVDEATDKYQCAVPAVLPFFHIFGFNAVMMNLMTRGSKLITFSKFNPELFLKTIVQQRAEHLYIVPPMVVFLGKHPAVTGEYLQSVRGIISGAAPLSESDAAAVLKKNKNIFFRQGYGLTETNGGVSVGRKTDVNHATVGYMFGSCAAKIVDVNTQEALGPGKVIIGVPDDVTGEAPKAFVVTQTDITTDEIKQYVNKQLVDFKHIKEVQFVEEIPKNPAGKILRKDLKAKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNM2</accession>
    <name>A0A194RNM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0378 protein KIAA0100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RNM2">
        <property type="interactions" value="1422"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNM2"/>
    <dbReference type="InParanoid" id="A0A194RNM2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1550"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2328"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2176"/>
            <end position="2185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2350" mass="262818" checksum="DC3F503DF6F61463" modified="2016-10-05" version="1">MSALFIVLLTLVAIYISVSWLLPNLLAWLFKRKYHIKLRIGRIAVPKLILRDVSLSKDGYSIHIGEVSFRSSFFNSEINKLVSVVINKLQITNNAEEKRSAVVETILKPLLSKQNSNFKEGQDATESDTINRQLKRIAEKNLLDFRDKKLPPSLIMFAQFMGVHIMDATLTVVNGCPRSPFVVEASAAEVRADGAAGGPARALAFCASALRVHLACRADGLLEAACSLHIEGTVKADGPLNVEKIHTVISNPSISLQDEMYHFIQKQKTRKPPEPKNYVENDDHLSTLIPRLSPIIPKIFSLKIEKTTINSGGKTTTTTLQSLQVNSRFSAAAEGVPGAGSPQLYVAFQADQLQLITEQHDLLFLNKIKLDAKVNSRFSAAAEGGAGAGAGSPQLYVAFQADQLQLNTEQHDLLFLNKIKLDAKLEKGVLNLYLIISTLNMSYIHEDMFKWYRSIRDLNSKMKPMQLSGDSSSGGAGGVPAWVRVALCSCVVQGCAELRGVSLRARRTAAGPALAAGCGGLKVKLDQLLDTREEAYKWGVAQLVVGARHWSAELLVDAGWAGWAGREPPPRRHHAWRSALLAVALVKCGSHPPRDCKVEAMMDCLRLEWSKEIADAVISMVECLNDYKTPCKAKLPEVVDESPANISVNVALSHINLFLIVSDEICLMTRIDAVTLEKTVNKAGALVSGLKVVEMVPYKANVQCQRSDEITSTFFHVRLLRVEFLHSKDRSTNLLDFQFLETVDFEWSANMHLKILTFVRAVKSFRKELKELKESKIETEDVGEDKKKPLDWRVSFKGDTNLMLLLSEDNNMLFVTDDLTVGCEEWCGVSVSWGQLKMVLNGEEVVVVEGYSQERAHDDPDVRVERSANEGFLLPWNKVWSVNVESVRVVFPYKHRFAEAVQGDFVSLFKWLKLVHGVKKRPFTADSPLPSDLHIKIEEVLLEMSDDPFEVKLRDNYELLEDEYKESEKRRTMLDAKVQELCKPHLFLPAGKVEQLYAALRQKDAQIYVQRCRAAPPPRTRLVACCLSALRVLALADPSVHGAHNAQARLRHIDWDSPWPEEGIDFNTLWCRSVSVQCAQWQLRLRDFPQPLLSMTHLRLWGTLLAAEEQPPPRALRTVTIEQGAPWGKVELERSMMPLKWYYDLCCEMAEYSYAFGPCWEPVIAHCNLAFDQVSRPSLDPSAPLAWWDKVRLLMHGRLTVNCKKFTCLLHVSLDPYNTTEEMEVTWNDLVLDWTNGKLAFLGELNVFVRTASKYDDCRVLRVPALRLSVKLGWQCVGDPRDHHAVAPCAPTRLPEYSSNQEHDSYRAFRSQGLELHLGMDTKPVERDGPVLLLYGSTLRWFESLKLILSGVTRPTRRGRVFRNLRPRKPQLSRHYRHVSVALTLHNLQVFYWSSSSMQRGIEMRCGRVTCGARHRLSLAAAGDGLLRRPRALWTTDYMNCDLNDAEIWLKTPAPVADDKDNENSVLSPPAMEKCYCLSVRRVSYGREAGGATCSAGGAAGAGGGAAPAPAHRLAVHDLRGAWTKLNRDLAFALIDSYIKTQQLKKNLSTKALKEEEKPTTSPKQQRESDVVSPPPASAQSGGGCAAGMLAALVAEAGEAGGEAPVVFSDELAGAEGDAPPPHAPLRHALDDDNAHTACLIELVNSQVVLKGCETRGYVILCAARAEVRQRVRRAPAATAWSGALSAMQYYATVSAADRDQLDENIQWVSVEEIEERWSGAEISTLPDVPRLVGSGHSAGGVIGSTVGPGNDAGLAQLQRIVSRCACEFYYVTHEETESGAGGGAGWAQQPQPYDSFTLMHHDLDVCTNSLQYAMLLDVVNNVVLRVEPERRRALERRARMRFQLQLHQDRDHKQLIHKLQTQVRESLARLRRLEKEYYLKNRSITGHDPVAIAELKSLDDQVNECKEAAWSLGEELDAMVRAWRETRSAAPAVRAPHAPPHRHNEICFKSARWRLTDADGQLGIADLLLTNFLYTKTSRSDDSVEHQLEVGYVRVTNLLPNEPFPEVNECKEAAWSLGEELDAMVRAWRETRSAAPAVRAPHAPPHRHNEICFKSARWRLTDADGQLGIADLLLTNFLYTKTSRSDDSVEHQLEVGYVRVTNLLPNEPFPEVLVPQAASGRAPLARRAALRVFCRDRPPVGGISVKEHFEVNIVPIASFFNTMLKFCFPERDPEAMEEGEEEAGREERAPSAASSGGTKRRTKKKDSNSNFYVKRDKDKDDVEKMKERAEKNKLFIYIKIPEVGVRVSYKGSKEKNLEDVRDLPLVLPTLEYHNVTWTWLDHLLATKNDTRRVILSQAIRQKLQLGRRAAAPPEPHEEDKVRLLLGERTVAENKPQKKSTPSVFKFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPT0</accession>
    <name>A0A194RPT0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MIX23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPT0"/>
    <dbReference type="FunCoup" id="A0A194RPT0">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPT0"/>
    <dbReference type="KEGG" id="pmac:106718114"/>
    <dbReference type="InParanoid" id="A0A194RPT0"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15863" checksum="1F3104A6020FB704" modified="2016-10-05" version="1">MICPDFLEFQDILKKMRVLDDKIVYTLNTSIPTESFKTKVNATEACQELYHQIQKGHEERESVIKKCIVTTADSVKKLLSAKETNPDDFETLKNLKAEQRKLRLLQTELSVEEVIKEKTTKLFTEKCRSYYKPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSP0</accession>
    <name>A0A194RSP0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSP0"/>
    <dbReference type="FunCoup" id="A0A194RSP0">
        <property type="interactions" value="1291"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSP0"/>
    <dbReference type="InParanoid" id="A0A194RSP0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="15365" checksum="62799AA37EE80E25" modified="2016-10-05" version="1">MNLRDADTGKILWQHNEDMSNPDVEHEARVPKRILKCRVVSREMNFSSIESMDRFRLEQKVLFKGRCLEEWFFDFGYVIANSTNTWQSIIESAPESQMMPANVLNGNVVIETKFFDGDLHITTSRVRLFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBQ8</accession>
    <name>A0A0N0PBQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBQ8"/>
    <dbReference type="STRING" id="76193.A0A0N0PBQ8"/>
    <dbReference type="KEGG" id="pmac:106714163"/>
    <dbReference type="InParanoid" id="A0A0N0PBQ8"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="37835" checksum="222B1790031CA0CB" modified="2015-12-09" version="1">MRSKGLIFRYIGIIARKFRAFQERWLLPWWDSGGMSTAPLWALDTLVLVVKLCSTCAIAVVRVLIPPSMKNLYGETVLITGSGQGLGRELAIQFAELGATVICWDHDTPRNNAVVNEIRKKDGECFGFTIDVTSREQVSSLGARLLRQLSDVSIVVINAGAYSCGPVTHFRPEAIAKLIEINLLAHFWIIQAFLPNMIEKRRGHIVAINSSAGLMPCAEMVPYCAAKYGLRGLMDAITEELRLDTWTKNIYTTSVYLATLSTGSYPPPAHRFSSLYPEVAPKDAAKIIIDGIRKNRKEISIPSIMKPLIVLNNILPYRIRIILMDFFNFGHRGWFSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC11</accession>
    <name>A0A0N0PC11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC11"/>
    <dbReference type="InParanoid" id="A0A0N0PC11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="367" mass="41597" checksum="FC507551FE870539" modified="2015-12-09" version="1">MTLTYRKFTQIGTETSYVIITFGLIIARVFQEIPRGRRILEGIFLGFGLLFFLILGGLELASLDSIPRNLVVNASVLGSFSLVVAALFLLDLMGPRTYYTNHHAQTLPVSSPQLKEKKVSIVTAPTTNGSLANGKANGHAPAERPKDLDLEKNKTEEANKKFETDLFDEHKNGFIKFNDVIEKELEKSKFGSVRNGGVENENYVKLTDPLTESDRIHYERELAKFNERYFRDFLERVEGKLSVREDYLPELQTPVFSKVKTGRLKSLYDDVSPTYEQKRQSKSPSRAKTVSPPTLQQLEDYLRGSTRSRRSETPALFPMEPIEERDREAGETEGRASGTPTDPGYVQYTAGRWPDTRQIRTPRHSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCA2</accession>
    <name>A0A0N0PCA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Blastoderm-specific protein 25D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCA2"/>
    <dbReference type="FunCoup" id="A0A0N0PCA2">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCA2"/>
    <dbReference type="InParanoid" id="A0A0N0PCA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905">
        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="813"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="348"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="608"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="892" mass="97771" checksum="24BBC64B0804F9D1" modified="2015-12-09" version="1">MDCADMNHYEKQLYIVFKTFDVDNEEALEKSAVQELCDALQLEDRGATLIESLFERHPGRVTFTQFRNGLLSVLGGGDSSPLAHTATAASNLSHHSDDESSGREVAPKFVYGAKKYGRRSRPQHVSSEEAPRPRVASDSRLDGERSRERMRCKRSASAMESRVPSTVDSDVTAEALEHDRRVDREHALSLCRSLQMTGIDSRIVDGVFETVSTDEITVGDFFDRLNASLSTSIAASIDGVSTSSHNILPNSEVANRVPDEMSSEMIVEAFERSGVRRPRRLLLELGFAAATVRPSDLERALDDELQALTASPEGQPEARDFLSLALLTLLRLRLERSQQCICATVAERDKLRVDLAEANRRARLLAQDVDDNHARIEDELKASLRQVEARHNEATRAAAAEMSREREKTAATLSRLEEEIARRADVEVRLRADAATLCERVKDLEMRAITAEEKAQHSERERARLAADLKAAEEAGAVAADASRSSALQLEAALAELRLENKWLRDRNDELCAELEVAGSYVTEGNAQCTVVKTLQETLARIKGLSLSKDSTCESCRAVADMIASIEGTAANAVRADTGVQTDACAGAHNAAADEPSHSPQQADADEKAQLLAVISELESSYDQLKREYEQSEEYWAGKVEEEREACGEELRAADERLTELVARIGEYERQFARAPLPAIEERAALEQQVTALEDEFAAYRRDAEARLAARTADLAVLRRRLADLERRNAPAPNPAPAPAPASASAAVSTRSLTSDIYVITRIETSERQPYRAEHVVVAELCSVRGVRGVRGVLRVLRVVRVRCGCAACARRTGGARGAAPGRTPGRRRPARQGPVPGELSAGTPAAAALTSHRLASPRIADGWRQQQSCRLAYPKPRRSAASPRCGNQILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCX7</accession>
    <name>A0A0N0PCX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460401">
        <property type="protein sequence ID" value="KPJ14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCX7"/>
    <dbReference type="FunCoup" id="A0A0N0PCX7">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCX7"/>
    <dbReference type="KEGG" id="pmac:106710908"/>
    <dbReference type="InParanoid" id="A0A0N0PCX7"/>
    <dbReference type="OMA" id="AVEQVHP"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857355" evidence="7">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="54"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="29384" checksum="C9682A1525C8C712" modified="2015-12-09" version="1">MKLFLVVLCGVAALASQSAAEEPILLHYHDNAGVPLAELIRQSEEAADFDGSRIAGGSLANLGQYPYLGGLVITLSDGRTSVCGSTLLTNTRLVTAAHCWFDGRNNARQLTVVLGSARLFSGGTRINTNNVQIHASYNSGNLRNDVAIISTSHISYGNNIRNIGLASGSNQFAGTWAWAAGFGRTGNNAAIGNNQALSHVQLQVITNSVCAQTYGTNAIVASTLCTSGAGSRGVCPGDSGGPLVANNQLIGVTSFTAQRGCQAGLPSGFARVTSFHSWITSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEI0</accession>
    <name>A0A0N0PEI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein Xfin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459805">
        <property type="protein sequence ID" value="KPJ19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PEI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="37"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="202"/>
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    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="263"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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            <end position="902"/>
        </location>
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            <begin position="991"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1723"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1751"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1850"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1969"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1997"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="2114"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="2142"/>
            <end position="2165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2169" mass="254826" checksum="1633B3C8C484E224" modified="2015-12-09" version="1">MQKQWHNLTTLLKYSNATPFKDRNDAGYICAYCFKTYPDPDVLRNHTQYEHVKEKPTYKAGTGMSSFVAFLDVVNLKCTICDQAMDNLKSLIDHLVKVHDTKYYVGLTDYFQPFKLTNDQQMKCCLCNEVYHNMKLLMQHMNAHYRNFICTICGAGFVNSFRLNRHETTHAKKKSSFPCRQCGQVFAAESKKKAHVNTEHKGIAGDSVCQICKARFKNYYQKTRHMMQIHNVEGIKCEVCDKRFNLKSNLMLHMRSVHLKERPYECSECNMGFFIKRHMIGHYLATHTNERKFKCDVCGKAYATQNRIHRTMRKIGTQSTVLPNKSRGRELMKHRNNIREILKSSNATPIRCHAGIGYACAFCDKQYPDPKDLKKHTLEEHDSKTKRKFMEGKQMFSYLVKLDITSLKCNLCDSNIPTLEQLIDHLINLHNRKFYIDINNHILPFKFDSDLLLKCVYCVSVFNKFKALLEHMNIHYRNYVCDECDAGFVNKNILLNHAEGHKKGIFKCDFCDKVFDTHRKKKSHEKSVHIHFNMLNRCGYCDQRFNTYSRKLEHLIKVHGVQSPLLKCKACDKQFETQKSLTVHVKRDHLLERRHECKICDMKFFVTHQLQQHMIKHTDLASFVCEVCHKAYKRRKTLKEHLRIHADDRRFKCEHCGQAFVQKCSWRGTRTKLKYDRLSAEDIKEPNVSVDNKSVPKKGIELSKHRKNVREILVNSNATPIRCYGGVGFACSFCTDEYPDPADLKKHTITSHKNISKFMNGKDLYRFLVKLDITNLKCKVCDGTIDDLEQLIDHLRSKHNKLIHNDMKHQILPFKFESETLRCFICSNKFHKFKTLLEHMNVHYRNYICEVCDAGFVTKGIMIKHSECHKFGSFKCDYCTKVFNTFRKKKSHEKCVHTHSNLLNKCGYCNEKFNDYRKKQKHLKDEHGVPTRELKCEACEKCFASQKHLSVHIKRVHLIERTHQCTDCDMTFFSSFEMKRHMLKHTGAKDFQCSVCHKWYGRRRTLQEHMRIHADDRRFKCEYCGQAFVQKCSWRGHMRAKHGVTRLAKVDRRLVQNKNSAKPMLLKFTTRITPASSVSGNNLLTESKKNQHNLSLILLNSNANPIRCKDSQGYGCAFCTKQFQQPTTLKKHFLEEHNSDRFIKFMSSKVFENVVKLDITYLSCALCDTEFLQLNDFIKHLKATHRKEVYEDVKSEILPFRFDTPELRCAICSTEYTSFKILQTHMNQHFGNYTCKICAGGFVTERLLQSHIKRHGNGEYKCTQCDKPFPTLNKRQEHVQRVHLGLNKRNKCNHCDERFVDYWQKVKHMVKMHGEPPVVLKCQACERTFNNQRVLSRHHKKDHLLERRYPCSECDMKFFTRSALIKHMAKHTGLRQYTCDICHKSYGRKNTLREHMRIHANDRRYKCENCGQGFVQKCSVAGLVKIEKTGQNEDSIKPVESKVTTRTTRAPVRRNRALTDAKKNKHNLSIILRNSNANPIRLKDDNGYGCMFCSKKFPQPPSLKKHFLEEHNNDKLNKLICSNFNDIVIKLDITYLCCVLCDKEFLQLNDFTQHLKTTHKKSLYVGFKSEIIPFRFDTPELRCAICSAEFFTFKILQTHMNKHFCNYSCEICGEGFVSKHLLHGHVKRHGDGKYKCTQCEKTFSTINKRKEHLQRVHLGLNKRNKCNHCDERFGSFSLKTKHMLEIHGVSPAVLKCQACERTFNNQTALTRHHKKDHLLERRHACSECDMKFFTSFDLVMHMPKHTKVRQNTCDICHKSYGRKTTLREHLRIHANDRRFKCVAELLKVEKKIDPNGDRIKTVTSNFTKTTLPTVCGNRVLSDAKKNKHNLSNILHNSNANPIRCKDDTGYCCVFCSERFPQPTSLKKHFLEKHKNEKLDKLMCSSFREIVMKLDITCLCCALCDCEFLQLDDFMQHLMSTHQKNMYVDIKSEIIPFRFDTPELRCAICSAEFFTFKILQTHMNKHFCNYSCEICSEGFVAKHLRQRHIRVSHGNGQNKCALCDKTFPSLTKRKEHVRKVHLGLNKRNKCNHCDERFVDYWQKIKHIVKVHGEPPVVLKCQACERTFLNRRVLSSHYKKDHLLERRYSCSECDMKFFKKLELSQHMTKHSKLKPYTCDICHKSYGRKKTLREHMRIHANDRRFKCEYCGQGFVQKCSWRSHMRSKHEEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEL9</accession>
    <name>A0A0N0PEL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox protein ARX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_02869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEL9"/>
    <dbReference type="STRING" id="76193.A0A0N0PEL9"/>
    <dbReference type="InParanoid" id="A0A0N0PEL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="18200" checksum="EB6F1CBA7B0FC053" modified="2015-12-09" version="1">MKSESGTQSDSEHEHEHEHEPELDHDHEHEHEHGEQLDALDAMDAMDTGRPRKQVRRSRTTFTTYQLHELERAFDKTQYPDVFTREELALRLDLSEARVQVGPLTCYCAARRSGRAVHRGLRLWLRRRLEDIRRLISARPPAPHPAPCTPHHVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEU9</accession>
    <name>A0A0N0PEU9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459620">
        <property type="protein sequence ID" value="KPJ20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEU9"/>
    <dbReference type="FunCoup" id="A0A0N0PEU9">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEU9"/>
    <dbReference type="KEGG" id="pmac:106720901"/>
    <dbReference type="InParanoid" id="A0A0N0PEU9"/>
    <dbReference type="OMA" id="VIRNEAC"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857433" evidence="8">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="54"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="30537" checksum="02B8D4411DC5AB2D" modified="2015-12-09" version="1">MWATILLVGLAVFAAGEPLGPSPITLDYHATVGVPEAIRIRNAEEAMDFDGGRVAGGSTVNLGAHPYLVGLLVQLTTGQTSVCGASLVSNTRLVTAAHCWRDRSNQGRQMTAVLGSVRLFSGGTRLTTSNVNMHQNFNVNNLNNDIAVVVIPRVNYNNNIRAINLPSQAMQILNFAGYTAQVIGYGVTNDSEDITTGQVARRRNLEVIRNEACAQAYGFNVIASTLCTSGQGNVGPCGGDSGGPLALNLSGQRVLIGVVSFHSAMGCRVGFPGGYARVTSFTPWIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFJ6</accession>
    <name>A0A0N0PFJ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01037349">
        <property type="protein sequence ID" value="KPJ21314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFJ6"/>
    <dbReference type="InParanoid" id="A0A0N0PFJ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="272" mass="32204" checksum="A3F2500A33649544" modified="2015-12-09" version="1">MNIKYALLLQFVIVNVQYLPFIMLIEREQDTSEYWRETEILTLVRHDEEGIDYEKCEQNAPEVSALRLPARRTVRPICRTAYDYQLCPQCPRFSNRTECELFKDSCKERTVMPSEYRTYCDQKYGKWRTMFLPADYSQCRCCDECIFYRELDQSCMEDEYNFDTEEFLPVTTVDFRAGCNPYWGHPEQEVKALRCDPVLRRCVPVTIPVLPKDTLSVRRSFRYELPTVEDCPVSCRGYDCQSLVHEDQCPQGAFLPDKDYCNCCGRCSTFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFL2</accession>
    <name>A0A0N0PFL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040967">
        <property type="protein sequence ID" value="KPJ21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFL2"/>
    <dbReference type="InParanoid" id="A0A0N0PFL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14613" checksum="523850C98315ED1E" modified="2015-12-09" version="1">MPGHTGSPYWAAVDFDSEGDDDQSPQSHRRLYLDPWDNDAFGMIHGDSPESSQGDLMNSFAGEPVSASFYYVPTKNYDSGEDFPSPMKRIVPPEDIPVYPMHGRKSSKIAIPEYPDMPIYNTRHIRKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFT2</accession>
    <name>A0A0N0PFT2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01030744">
        <property type="protein sequence ID" value="KPJ21222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFT2"/>
    <dbReference type="InParanoid" id="A0A0N0PFT2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7315" checksum="2DCD195000B16EAE" modified="2015-12-09" version="1">MTLLKETGRNCVDVWPRYLMQDGKSDDVWRQFVSVLGGDAVAKDTTPSDEHPILAVSPLLEESLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5Z5</accession>
    <name>A0A0N1I5Z5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Paired amphipathic helix protein Sin3b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone deacetylase complex subunit Sin3b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcriptional corepressor Sin3b</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04584</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SIN3B complex, which includes SIN3B, HDAC2 or HDAC1, PHF12 and MORF4L1. Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89. Interacts with MYT1L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I5Z5">
        <property type="interactions" value="1433"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I5Z5"/>
    <dbReference type="InParanoid" id="A0A0N1I5Z5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000005">
        <property type="entry name" value="SIN3 transcription regulator family member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="16">
        <location>
            <begin position="786"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="491"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1058"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1373"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1470"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1375"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1387"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1500" mass="161275" checksum="3B549E04F4DC67F4" modified="2015-12-09" version="1">MSGLMKRTGGRLGPDETAPPHSAPHSAPHSAPHSAAQVQQAATTMHSLAQAAAQPQIIGQYKIHTYYIQERFLWSALALWPWPRPPATSTTPQTGYRLSAIGVSSSSGVGVGVGGMVPVGGGFARASRPAAPVINYHLKAGVQYGAHKPPAQQPPQPQQPPRLRVAHAPTPLGRQSPGAVGGVPGGAAPGGPGVAPGAAGGPGAPGAQFQRLKVEDALSYLDQVKFKFSTQPQVYNDFLDIMKEFKSQTIDTPGVIKRVSNLFKGHPELIVGFNTFLPPGYKIEVQSNGQVSVSMPSPTGLGGVGVGSVGGGGVGVASVSSVGVGGGMVLGVTHASQPQLLHLLPVQPSVGGAIVHNMTVSAPAANTLHHISQAHQQIEAASIHHNQGCGGGAHAAAAGQPVEFNHAIEYVNKIKSRFSRQPDKYKRFLEILHAYQRGHRDVKEPQARQQTEQEVYSQVAKLFENQEDLLAEFGQFLPDAKAVTKPAQYALHSAHPPHPPHARSPLSPPPPPPHAAQMESERFAATSPQPGAPHTSPAHPAHPALAHAHAPLPAHAPHPAHPAHPAPTAPAAPVLKHPTSVSVPVPPPQHHHLKRSPSFTSTSQIARSRAAARARRRVRARARAGAGAGALRDVSYAEAAKLATAQDYSFFDRARKALRSQQVYDNFLRCLLLFTNEIISSSELVSVTGPFLCRHPELQKWLQDFVGPASPSPPHTPTAPPPAPLHAHAPYAATGGAAGGAAGGATGPLLGYARDRLGDGKLRYEPPQLRNERAQGDAAMDIDLTTCKRLGTSYCALPRDAAARRCSGRTPLCKEVLNDTWVSIPTWSEDSTFVTSRKTQYEEYIYRCEDERFELDVVIETNAATIRVLEGVQKKMSRMAPEDAAKYRLDDCLGGHSPTIHQRALRRIYGDKVAVDIIAGLKKNPVVAVPVVLRRLKAKEEEWREAQKGFNKQWREQNEKYYLKSLDHQGINFKQNDLKAMRSKSLFNEVEAAYAARRPAPHLVVDYQMQSRQEAIKILRDAAELLIHHARRQTGIQKAEKRRIKQLLRHLLPDLFAHPRQPLSDDERDEEDKEEAASPAQRDDRPAPAAPAPPAAPAAPASKPDKHEIDRVDEPEDDYKDYPPNEARFVCTSSWYLFLRLHGVLCARLGAARRAAAALAEAGGAGGGGTAAAAALRLRPCNLPPEAAEPRHYYGALLELVRAVLDGNTEPAAYEDAAREMLGIKAYPAYTLDKVVSIAVRQLQHCASEPWSVRAAELAARGMRAGAGYVRRAARYLRQDHTAFLVRVYGGDECKVTFELLEGGAEGRASPHRDVARLSPPATARPRDPLPAGVARVAAWSLYAERYARPDATPPPPPPTAHRHKPVFLRRNARRAGAAPSASAAPCAPPAPSSAPAPPRPPPRPRAAASLRVCTTSLSARWPAACGWWRGGRTSHTAPAVWPPRAPRTPVCTPQGAPASEPGCADICARRNPHTPHTPHTHNYPLAPSPRSCELPKHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6U5</accession>
    <name>A0A0N1I6U5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein disabled</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461156">
        <property type="protein sequence ID" value="KPJ08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6U5"/>
    <dbReference type="STRING" id="76193.A0A0N1I6U5"/>
    <dbReference type="InParanoid" id="A0A0N1I6U5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="361" mass="39533" checksum="65CC0A568B2EB6C2" modified="2015-12-09" version="1">MPRPRCCRRSTNKVGASGRAVPVIVMRIPVLQVTQPATSDTSITYDVFTELDPLGTGRSKPYVDKKLFFQELKNPPKKVLKDLVPSHSLLSDIVPVTSEAKGEGYGPPTTMTSLTRHSGGSVAIAKPPQPPLYSGAFFTSDPFAETDPFDSTDPFSDTFKDDPFTSMQEFPKSSSLLIDETKQKLIRELAMEREVAQPAKNVFNGPLQVTLPPEPSPKSPRLQRQATDTSAVRQRPQPSSKLTGENPSPPPPLPPKKTVEVGLARPPPRPPHEHDLDAEDSEPGPPLPRPARKREPLADRSTKPQLSSAATNSSEDEYLTPAPPPLPAARRFDITLSQLLTCSMEDLAARYPPLLPNPHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7N2</accession>
    <name>A0A0N1I7N2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein wntless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">RR48_02653</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Ya'a_city_454_Pm</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynaptic cell membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7N2"/>
    <dbReference type="FunCoup" id="A0A0N1I7N2">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I7N2"/>
    <dbReference type="KEGG" id="pmac:106711917"/>
    <dbReference type="InParanoid" id="A0A0N1I7N2"/>
    <dbReference type="OrthoDB" id="5804250at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="23">
        <location>
            <begin position="48"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="22">
        <location>
            <begin position="227"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KPJ14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="544" mass="62411" checksum="D4FAA99F4FD379C4" modified="2015-12-09" version="1">MTGTIIENLSGRKLAVLVTFLLLCQVTCFLIGGLIAPTPANAQNILGTVCKDTTTMKNDTKTWFYNRGKGSCKTVDLGDMHQDLSETDVVFAFQMPVPRDSRTLDFSRWQQNLIGVLQVDLKYHSQMEVKPRSTITIDARLAYKNKGDADDAWKLYTQSVEKRHLDCDIDLKTEEYLYNCSAIPLFELGSLYHDFYLLNIRLPVDSPSMNTNIGHIQDLWLTVINQNGGFTKVWLSLKTIFFPCIIGILTWFWNRIHMLQRKPVLLEKMLLCLGIALCFLNMPFEYLTLHFDLPFMLLLGDIKQGVFYATLFSFWLIFAGEHMLIQDASAQSSLKQYWRHLSAVAMGCISLFIFDMCERGVQLRNPFYSIWVTDIGTNLALTFIILAGISTGVYFLFLCYMVWQVFINISQKRQSLPTMCSVRRLHYEGIIYRFKFLMLATLLCAALTVIGFILGQVAEGQWKWDESIELEYTSAFFTGVYGMWNIYIFALLVLYAPSHKRWPVNESTSDTQNLSEEIEFSPLPSEHNSEISSLTSFIRKTTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8H0</accession>
    <name>A0A0N1I8H0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8H0"/>
    <dbReference type="STRING" id="76193.A0A0N1I8H0"/>
    <dbReference type="KEGG" id="pmac:106713621"/>
    <dbReference type="InParanoid" id="A0A0N1I8H0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="287" mass="32552" checksum="B9863E2EA7853F88" modified="2015-12-09" version="1">MNTHKNHVINDPLSVIYNEGHWRLSKVSPLFNIQPNAIKFKQYASKIRQGIITVIPAKPGMKFSVLIEAQPYLKYNEDDPEAFMITVSSQESNKSKLVYTCILLSWGVSMKVPESIHLPFMLEHGEKKIGVSVKTTLQNLFDCTIKQFYFSQHQLLRFGFGFVENDTSRSTDPFTLCYTIVADHKNKLSLSFEVGDVNMIWHRAKGDSTATSKTDKLAYQILQNQIFFSMQLDVTPLDLCEINLTKAEVKSDGTIKMKTPELVNCVFTVLNEIISSQTVTNNNAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9A4</accession>
    <name>A0A0N1I9A4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadherin EGF LAG seven-pass G-type receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460195">
        <property type="protein sequence ID" value="KPJ17213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9A4"/>
    <dbReference type="STRING" id="76193.A0A0N1I9A4"/>
    <dbReference type="InParanoid" id="A0A0N1I9A4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="182"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="593" mass="67245" checksum="AD0A52DDA0FECBEE" modified="2015-12-09" version="1">MKHILKFESATICCSIKERRRLYRLVNAEQIDIIKNKQVPKCDANQQNKTVAKNHHVRRSSVDDSFFENQKKESYKSYQPVAIKYHKTYPRADERTEYDTNSYDNDYDAVVSNFTSSIYDDNPPLYPNPEDFTKNLGENKEQNEVDLPDDSLADADLKEHNIIDSVTYLYGFSNCQGSKNGWIILIVINTAISCTLLVVAMLWLLISEFAAKFRQESKLYPITINLCSCFIACALIYAKAIGGSSSPYVCEKIALLLHYTYLTCSTWIVTMAAALTEYCAYDSIIPLKYNYLFAYGIPAFVVMFNYAISLEQYEIKHYCWMSLEKGMVMGFMMPAMLLIVLNTGIILLGLRLVHRKQSEAIQARLQELLDRQEANFRRTEQVSDNIRMNENNEMIDNLYAAGTSRKNTDSSETLDKDYNASDDNCYINIDLPNECNIDEGMEPNIQDKEGQYRNGGNATYLEPIWMKFNWGTEGNDLKTYLNLCLVLEPFFAINWVMGVAAIENAAHWTTPTIYLVLSLTMYVYFAVTICSNLPILAEKTPVAVVTSTCVNDIVGEPTIIPTRTTDNIPLLDPAVQQPNGTPAPADTISTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9L0</accession>
    <name>A0A0N1I9L0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein abdominal-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460544">
        <property type="protein sequence ID" value="KPJ14088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9L0"/>
    <dbReference type="STRING" id="76193.A0A0N1I9L0"/>
    <dbReference type="InParanoid" id="A0A0N1I9L0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000193">
        <property type="entry name" value="Ultrabithorax, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022132">
        <property type="entry name" value="Abdominal-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12407">
        <property type="entry name" value="Abdominal-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="138" mass="16734" checksum="C4C597A70BA52FDB" modified="2015-12-09" version="1">MPLSVSSPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARREREEQDRMKQQQQEKQAKLEGQHHGHHVTHHHDPMKMPIDKGSNDLLKVNKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAQ7</accession>
    <name>A0A0N1IAQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAQ7"/>
    <dbReference type="InParanoid" id="A0A0N1IAQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="29070" checksum="9174B8ABB9EF198D" modified="2015-12-09" version="1">MGENKDEPVEHIWISGRLNMTKDPNSDLVTYAWQNPITGKRIPDSKSEGEALFASFHADHRTLDPGTPCRHHKIATRPERMVTSDTSPYQDITLQPEVAVEHIWISGRLNMTKDPNSDLVTYAWQNPITGKRIPDSKSEGEALFASFHADHRTLDPGTPCRHHKIATRPERMVTSDTSPYQDITLQPEVGSSTYMLPWLDEEFSMDNPCLNLDRQDHLNGLVYGMSCDTPQYSICMIEKNPPKTGSKENMIEGNYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICI9</accession>
    <name>A0A0N1ICI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein dispatched</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460968">
        <property type="protein sequence ID" value="KPJ10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICI9"/>
    <dbReference type="FunCoup" id="A0A0N1ICI9">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ICI9"/>
    <dbReference type="KEGG" id="pmac:106716012"/>
    <dbReference type="InParanoid" id="A0A0N1ICI9"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="414"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125848" checksum="5339A344CECC4A44" modified="2015-12-09" version="1">MLTFYARFIVRYSYLYMFVVIVILTILTVIPLICHEFPSFSDPIVGFETRGTSLAQRFIAWENLIDETRPSKRLAVNPKEIADQKRMNHTYHNRIQNKGKINRERPKNKGRNKKKKQKYYSTGIENKIEISDNSTAKPSVNGHVHWGFGKNVSYEDVNAQMLKNHTRKQWVSLKSMQRTPDKIQHNYATGMCGAPVSDYAHLIVSNSENSSLLEFENVQKLCKLQSLLVQLGGKVYYKLCQRSVRDDEMCCPVWSVPNYIALMSGKTSCENVTKEDVMNAVIILKKCASYFHDFKLMASCELNQCRVPQYCSQYDAVYNLLFYLIDGNAFTPPMFNNTFVKNVVIFLPLACSSTVLPYYQKLQSSNLSYDTLRIPAMDFGLKNALFDLWIIQDTWLIGLGGIFVFICVWIYTKSIVLTLLLFIAITYTLGVAYFIYIYVFNLEFFPFMNLLVIVVVIGIGADDAFLYVKIWKMISNQLIRDNIVVQESELTEIKNVSSAGETILIQILEETLRHSILTMFITTLTTAVAFFASYISYIPAINCFSVFAGTAVLVNFLLMISWLPVSVFILDVKLYSSSKKPWSIVIYKAINEIGGDIRVILNRIIIAFVTKSYIGIVVILGAIGVGSVVIVFYTPGLKLPDSRQFQLFQTSHPFEKYDMEYRDRFLFERFGKDLGVGSKMPLRWIWGVKPIDNGNHMDPASTGHLVFDTEFSISEPKSQLWLAEFCRNLKGQPFYQHTLGPLLPNCFIETFRMFMSRKCIDNIDKIDRTPCCESSSFPYTKEVFDICILAAMESLYQTPRQLFMPGVAGPKFLRSANPPNVSAIVVEFESVVPYSMSYTAMNNFFLQVENWTEHQLKSAPPGMRNGWFLSDLHFYDLQKTLASGTVMALILSASLGFIVLIPATFSFIISICALTAMVFSSTVTIAILVLSEWKLNVLESVAISTSAGLAVDFSLHYALSYTNASGTKSTRVKYALTASSGPTAAAALTTGFAGIFLLRSNLLPYSQIGAFLALIMSVSWVYATFFLCSLLQLFGKNSGKDSATEERKSVSRVSSICSGVPNLESHELEHLADSNRTNITHSHSPSSVSATTVVLHEDCQNSLSSFEKKHSIDVDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICT9</accession>
    <name>A0A0N1ICT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein sly1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01041659">
        <property type="protein sequence ID" value="KPJ21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICT9"/>
    <dbReference type="STRING" id="76193.A0A0N1ICT9"/>
    <dbReference type="KEGG" id="pmac:106707419"/>
    <dbReference type="InParanoid" id="A0A0N1ICT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13889" checksum="24C9F5651CBD9C02" modified="2015-12-09" version="1">MSKSSGVENKAVMDLISDVSAGTAEDKMRLFIIYYLCTPQITDDEYKKFEAALLAANCDIQPMSYMKRWKGFTKMSSQYEGGGTKTVSMFSKLVSQGSSFVMEGVKNLVVKKHVSILYALTQDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE78</accession>
    <name>A0A0N1IE78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Atrial natriuretic peptide-converting enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_04974</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE78"/>
    <dbReference type="FunCoup" id="A0A0N1IE78">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IE78"/>
    <dbReference type="InParanoid" id="A0A0N1IE78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000019">
        <property type="entry name" value="Corin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="416"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="660"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="801"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ10151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115648" checksum="6A79DCF688C3D975" modified="2015-12-09" version="1">MLGSKLGVNWLTVTWAQSGMQLQPATADDPDSVRNRCGRAGSLAATPGERLLELLRPSAPTDTPAPRRHSTAACAPPPRPAGFVYCPSDALPYCPPSRLAPPRSHVKIPQPPQASPAQPPPVPQRTVPAVNPAPLHVPPAPAPAPHSVHRVVTPAPLAVPPPAPPRRSSPQPPRRVPPPTPPRPAQQAPPSTDTNGNRRTMPPTPTPTQSARLDCNKNPQPPAPRKPPQKMPDTPYTPPQNQIKRSPSSGSNISVRQDSNVSSDSFSQTSSPSYTTKTMEAPLLPHQNVNKSLNAKIARGLLLKEQQDKESASTSITKSMSTPASLQTIVRFQNGSNMSLHHRMLREMRGASGEGSGHKFRLVQLALNAVAILAITAALFAYFRANPAVQYVSQVVNRSVIVPWPAPAEPPGARNPAPGVCLPVIVSFCHQHRISYNFTVFPNYIGHFGQRDAQQDLEIYDAVVDVRCYELTALFLCSLFVPKCGPLGHMVRPCRSLCQETMRRCGFFLEVFGLSMPDYLQCEIFPESTDTDVCLGNREVKEARIRAAKPVCPSGFQCDVRRCIPHDWRCDGHVDCADRSDELNCRVCKHGADLHCGNQRCVSQVHLCDGRVDCPWGQDERNCRPDERHIHETCGKSMSNGNQSLLAYVRDIYYRVCMAVRLSEATGDVGRGELQVYRAANQSWFPACIAARALDSATAHKLCSMLGYSLVNRSSTVGGIGRAGRMHPHVGLEHAEHLHSEHAHAEQEHGAAQSFRAFQRREGGLLRELKDCRHDSAHIHLVCNNYECGKRRTIGGGTKRIVGGVEASPGDWPFLAAILGGPEEVFYCAGVLVADQWVLTASHCVGNHSDVNGWTIQLGITRRRSHAYYGQKVKVRRVVPHPLYNVGVAHDNDIALFQLAVRVRYHEQLSPVCLPPARRSLLPGTVCTVIGWGKRDDKDMSEYEPAVNEVEVPVLSRELCNQWLEHRDLNVTAGMVCAGYPEGGKDACQGDSGGPLLCKDPDDPSRWYVGGIVSWGIKCAHPRLPGVYAYVPTYVPWILRQLQLYNDDNAPSDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEA9</accession>
    <name>A0A0N1IEA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase 1, isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01030722">
        <property type="protein sequence ID" value="KPJ21219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEA9"/>
    <dbReference type="STRING" id="76193.A0A0N1IEA9"/>
    <dbReference type="InParanoid" id="A0A0N1IEA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8556" checksum="1B8A98538D8E47B9" modified="2015-12-09" version="1" fragment="single">INPQHTAPAIVDDGFALSESRAIAKYLAAKYGNNKYYPQDVKTRALVDQRLDFDIGTLYPKLIDIFVSIKLLMINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGM7</accession>
    <name>A0A0N1IGM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGM7"/>
    <dbReference type="InParanoid" id="A0A0N1IGM7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118740" checksum="277C010DE6EC0075" modified="2015-12-09" version="1">MDALKPKSNSSASTETDTNKSTEVTSPIYQKDVLMGGLKSKKNIEPQGIEKEGSKSPYNHSLSPSIHGSSSNLNESLRKSPLEVANSEMWIKNVNNWYDGLHNYFGPNDILLNRSNTRQDFDNQQMNECRNFDNNKEVNYNFEESISNPFLDLNQVIQKSKAKTSRQEENIEKDAIIKQYSTKSHPLISCSSKNKNTSLTQKYIETKRNLQVPNLAHNNPRNFRNMTIGNIKEEYYEQTHKLQKASDLDIANKETNQDKKGKKHNLNAVLSEDERKFPIATTSEEKQECYEMKDMSKLSSVTSQSNTEMELLEFANRITNETNSFSKFVEEQRNFFKKLEYNNNSITPKSNDIELKIEADVKDKENHSLFDKEDKACKIKTSAKSDKVIWVIDNKSEVNYHPMLLDNKIILTQSNSDGPSTNTNKYTALKDERIEKDSTEKLQLSKTNTEQIAKYKNDKKAKRSALTMLLLKNLFEKDQSMSGIELNVKEVDAAIPFSCITTPEVVSSCNTTPAHPAHPALTALPALPALAVDPKAQQNYGLKPVHALRSVDLGHSLSWALYGSRRVPCAGRLQPLQLGSCYRAVACLTGESPSAATPSAAPSAPTAPTAPSAPTAPTAPSAAPTHEQPRSVISSSLNGLPLTRSGFVTGASASASASVSADECKKSLDENGNSVQGFTSPLSGSSHNKKPRRKKSSKNETVIKSQEIDGYQGNKDLNEVLRFIESNAESARSNKVRAKHKDDDDKGKKRSTERRKDKESKVKRASSLEELSRTTLADLTDKPAPRPEPAKPKPERRSWGEDARESRDFADNAAAAALELTDFQTVTKKRKPRRRTDEPEPPRRARPPAPPSDRSNDSNDDMDSVHSLHSLPADATPARPAPPHPHASYADIARTRHNIPDLIESCNFYETEVGGEPTRVEPAPAAAPPAGDDYPSLEVLEARKKRDKPRAARKERAESEAPAPDVVSDRRPAVILLDRASRPHDMDGVTFGFDINEQLVGARRPRCDLVCDALEGAVPVPVRAGPLRYLPPPPPPPAHQHTHLLQIVDYVGGAWEDVVRCGGGKVRYFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGY7</accession>
    <name>A0A0N1IGY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460328">
        <property type="protein sequence ID" value="KPJ15648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGY7"/>
    <dbReference type="KEGG" id="pmac:106710148"/>
    <dbReference type="InParanoid" id="A0A0N1IGY7"/>
    <dbReference type="OrthoDB" id="6606882at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="22939" checksum="A11CE1B3004F04D8" modified="2015-12-09" version="1">MATVFDSPFIRQRLHRLRHRDFDLDEDQRFGRCDCTSYSYFVLSMVLFSVGTVITVLALGDTDGYILSNLGHMWLVGPIFICSGMMVAVKSMLYLRRKSVIQMLLHQRAIIRDMAAVQAEQAFGGQVPRTASSATLPPSYDALIASATTSKPQPSGSEPPPPTYDEAMCLIDDEKLRMENRIEHSAKQETSDQTSSINNDINFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH58</accession>
    <name>A0A0N1IH58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH58"/>
    <dbReference type="InParanoid" id="A0A0N1IH58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="139" mass="16643" checksum="B980A398891501C2" modified="2015-12-09" version="1">MRVVSKDFTKFTVVCHSVYKFHTFKYKNKIEQSLLYQFPKPQHKIIYAMYCYKGFPLLEKMHIYALRLRENGLIDKHVRDLEHEVSKATIKAKKDFKASFIFPWQVLIIGYGLSTVAFVIELIVDYIKRRRMQGIIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHP3</accession>
    <name>A0A0N1IHP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460058">
        <property type="protein sequence ID" value="KPJ17981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHP3"/>
    <dbReference type="InParanoid" id="A0A0N1IHP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="674" mass="76609" checksum="BB82163CA115B179" modified="2015-12-09" version="1">MCRNCSNWNNVRCPECGQIGHPASHCPDLWRRYHNTITCNTPLEENRQMKRHHQLFCSGCARRGHLIHTCRSSLPFSGLPINSPYVSLYNPVWSDKQNENTPQRNRPLVRYFTQDTPNPAETVSNKNDRNKRLSNSPVCHEGHTNKKRHMSNCEEVDTSRNTNSPMTANVNGERHPQNKDQYEDATKVVKESNKVTNDNIEPPKTNNAAEKQPDSVTMSSSNHDKKGQMIQDNEVSDTSDVVTTARIYVTNEIMEKLKAKEGEEWLNKFTQNNNVTVQKSDSNTFISILGKVGDQEAFQSDLREWIQSQENSDNVKTNNGMNQKHVENDSENFLCVNIPRNRYNLIRKITKALDSLNEDLGDPKDIYKELTYLQNHHQQLLKQKQISPKQLSNNRDNLNDVIKKLNMILIGQAGLANGSKHLRQLRILKEKLTSFRQKYIPTKMRSEIGEHYHYVFTALPREDYHDLLNKYYAVKKKLITFKKKNNEKSMKLGPAIVRKKLNRSWQKKNSKVEVNEADDGYGESPFVFKVPHALTLAEDRGAVCVADRERGRVACFRADNGTYLAAYSSWLIGDRLFSVAYAPVHGGRLYVVNGPGGGAPVRGYVVDYESGRMVGTFAPDGKFSNPHDIAVTSDGSRVFVPELDPYRVCKFIDDTPRNATESSPPAKPTATVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJ55</accession>
    <name>A0A0N1IJ55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00915</name>
        <name evidence="1" type="ORF">RR48_05703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KQ460033">
        <property type="protein sequence ID" value="KPJ18450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJ55"/>
    <dbReference type="KEGG" id="pmac:106716119"/>
    <dbReference type="OrthoDB" id="7379842at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="23527" checksum="EDDE9B886FC9EAB8" modified="2015-12-09" version="1">MDDKVNEIPRLINIEEKGSASYILEINPDVPHEVFRNQSTAVEVVVKEINGRNKKKKDTAHVNTDVTIRNRNKEIEGLKKQLHEAKIGTDEVIESSRIITLEIKKQLDKAYQRELKEQTRNIALQLENMKLRTLLDSKTNLVKKLLKELTNIRRVVKVVAKGLGSSAHSAHVTTKSDPGYRSFDKDLQHSFLVDALGVESLTFNSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ05</accession>
    <name>A0A0N1IQ05_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tuberin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ05"/>
    <dbReference type="InParanoid" id="A0A0N1IQ05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tuberin-type" evidence="2">
        <location>
            <begin position="338"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1289" mass="139925" checksum="F1D4CC0B9CF39DFD" modified="2015-12-09" version="1">MSSRDRDTKSFQDKLKVFFKKGGTAPVAARNELLVGPELERELSPETPLGRRLRAIREVGEKALQIRIQEGGVEKIWSCTRDLLEDSNVESRHAALCLLRRLAEGQEEQLLVMRTTLFHFLRATHAAAAPEDGPLRFRLLHTLTNSGKNINCFEEQIGAFLLEWLAQLQQPAQIIEFLQLIINVVKFNATYLDEEIVHGIINQSCYLCVYPAEGGVVHACLSLLEAVLSYSLLPRSALPAFVAALCRTVNLDQYCQTSWKLMRCVVGADIGHAALQELVHILRGSGETGDGGAADAGLVRGAVFYINMALWGPKKVHNLKVSFLAVLPAFLKALSGAQAAAVVVYEVVVALQSLVARVPHELHDPAAHVLLQTIFDMLFGLRVNAFNCVGFCYEASGAAVWGAAAAGPGALRLQPLCSPFLLAEPPAVRGQQPQPLQPKDLPPGACAFPAGRTARALTTALSKESEWTVLAHVLRALPGLLQARALLVGRRAHDLDLLASSLCAMVSERSPAFAEGVRASGGQKLSQSELHATALPALAALASYHSFLEPHTQQRIIRCLLRYGMVLRQAQPYINALTIFTLETRETMAKMLPEVLLDLSKISDTQAIASPMLEFLSTLTRLPRVFASFVEDQYMSVFAILLPYTNPSRYNHYVVSLAHHVIAAWFLKCRLSYRRNFVRFIIHGLHNYIIMPFEEQLHYKTNNFQQTSANEDSSNRQRSSSLGSKAVSRAPLAGSRAPGPAPAAPAAFHVELTETCIDLLARYTFTPCAVKPQRSDMAEFLFSGGQSTTWLVGHKLITITTSGCLQNSIKQGLCERSSLQMCAAVSPAGGQRAQPASPRRPRHVQRASHSHTPHTPHTPHTLQVQVNDNSDHSQTSSNNHLNVHNNHPPEVKRYSKHSLQHSRSTETSCSSLSISEALQPPSAPASRQNSAENNKSSDSILDALNQFSQRFEKTSKEMERETGEWGSRAGELAAAGACPCWCGGWAELHVRSPTGDVSWLLRLQNQMSWSQLQEWPLQDVLALLSPPAAAGPLDDLLDHAPHASHAPHAPHDNSHAPTVGAESRARGEPRPAAPATAAADLHKSSSDSVVTSERRAPLAAPLSAPLSAPPAAPLGPQPARVTSDVRGVPVCSMSTQPINIPGSPQRQSSSSTTDDDDLLLVLPESKSRHPVRRSNSSPEMSSSWKLSVRDEDELGPDADADDANHMIVLPRCEPTTAAMTLHATKKAAKKSDMRVSCEAIPEEISGTSPLAQPPQHAQHPQHAQNPAARAAPAARAAPAARAAPAARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ14</accession>
    <name>A0A0N1IQ14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459920">
        <property type="protein sequence ID" value="KPJ19321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ14"/>
    <dbReference type="InParanoid" id="A0A0N1IQ14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012542782" evidence="2">
        <location>
            <begin position="16"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="320" mass="36465" checksum="38448B733AC0BA58" modified="2015-12-09" version="1">MKSLLCLFFIVAAKAANLTIKLDEITIIPNIEKKEYRKSFVNEVINIFSALKNDNSSNNPVINQRSKDEISYSHVLYNFLNKTYVCGSPKSKEIAPDLLATIEAISQLPFMDYIITDPVKINTVNTVKKCASDTKTRYKSKKKKSKRKKDVTRSKKNETFFTGAFEESVATKEKDDKKIISIETKKLKDLKSNNAVIDQFRTILDGIIDDIDSKNGNKVEGKQVKIIFEIGDNLKSELNRKAIPKEEYKAKEIDKDRLTINDVLYRTNTAIKKIEESDGDLLRRRIESENDSDEKNTTEEDKTAKTLTYICPVSAPTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ59</accession>
    <name>A0A0N1IQ59_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tektin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ59"/>
    <dbReference type="FunCoup" id="A0A0N1IQ59">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ59"/>
    <dbReference type="InParanoid" id="A0A0N1IQ59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ20100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="636" mass="72294" checksum="22857D14FF1119A1" modified="2015-12-09" version="1">MGSKIEYVDSSHLYATNYVRNSKAIGVLWAIFTICYAIISVVAFVTPEWIGDLETEYPRKFGLWQICRADEAVEDCKGRLDDFFSINGLVFKIATVLVGLAVALALFTICAMLLFFFCQSTTVFHICGWLQLLSDMETLTTFPEKNKCPKVCTDIGAFKKAEKSPEQVKEEIKEAEDAKAKAAEDQKGGADEGKETEQLEPKPGAEHYFEIKPGPDGKVDWTPLAGMTGTRPKVNKYSISRYSLNEWRHHNESVLDPSVITESNIIDYNAKTAMMQAFGTVDKQQNDNNERLKQKAKDLYRWKVEVERACKAITEEVELLEIERQRLKGASRVLMLPESISRECLDLRSNRYEPDLVSDLAEQELIKEMNLVSEVRATLKSTLEKIEEQMLINKAAKHRIEYDWCDKSMAYDTETLNIGLNTKTNTILFKPGSTRFGEFSAPLEYWEYFCRENVQNCEAARQKSADLRGSLNAILVNGGRKLRTQADKTDIILAETVAITQELCTKLEETLRNTLQKIADMESLIGELQNSIRKMDAAMKLAQTRLDNRNTFRCHGESVRDQPHLGLIEEVKKIHETVTSLLGQLKKAEKVRKELCEKRIALEKDIASKRKTLNIDRDRCGMVRSHYPSALELAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQF7</accession>
    <name>A0A0N1IQF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mevalonate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01001897">
        <property type="protein sequence ID" value="KPJ20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQF7"/>
    <dbReference type="STRING" id="76193.A0A0N1IQF7"/>
    <dbReference type="InParanoid" id="A0A0N1IQF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="12346" checksum="6B03F204E8B927C0" modified="2015-12-09" version="1">MDILEVSAPGKVILHGEHSVMYGKTALAVSLGLRSSVVLRLKTTGEVLDFSDDEKKLVSGWAFNCERIMHGAPSGKHRQHDVHVRCSSIIQKGASTSTKAEPRAARAAGRLRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQS4</accession>
    <name>A0A0N1IQS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trifunctional purine biosynthetic protein adenosine-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01030921">
        <property type="protein sequence ID" value="KPJ21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQS4"/>
    <dbReference type="STRING" id="76193.A0A0N1IQS4"/>
    <dbReference type="InParanoid" id="A0A0N1IQS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="7812" checksum="53AD286B017FCF8C" modified="2015-12-09" version="1">MLRTFNCGIGMVLIVSPEDQADVMNITRSFGAMVIGSIQARPAGGARVLVDNFASALDFTRRMPLLNNKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQV8</accession>
    <name>A0A0N1IQV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rho guanine nucleotide exchange factor 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050533">
        <property type="protein sequence ID" value="KPJ21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQV8"/>
    <dbReference type="STRING" id="76193.A0A0N1IQV8"/>
    <dbReference type="InParanoid" id="A0A0N1IQV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="23998" checksum="85E0C8E04BC3264A" modified="2015-12-09" version="1">MLELICSGFLSTGQLRNTLSRARELCERWRNGRETPSPPAAPDDDGGGRLARWFSVRRGSAHHYDMHTHDTDKMPKLPELEEDMFSCGGEVRGGRVPPPSLGPPPDALTAVQLRRRHVVAAIIHSENSYVATLQRLVNVSILVLSFYLHFCIGIKQSVICKNHTIFFVEIFFILKTQRTLFLISIEGSLIKLNTKVRRTSERLFHHRNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGM7</accession>
    <name>A0A0N1PGM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transformer-2 protein-like beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGM7"/>
    <dbReference type="FunCoup" id="A0A0N1PGM7">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGM7"/>
    <dbReference type="InParanoid" id="A0A0N1PGM7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="29693" checksum="3614137350248BE8" modified="2015-12-09" version="1">MSRGHSRSRSRTPPPPKSSSRKYRSPTRSRSGSPRRGYRGSRYSRSRSRSYSPRGSYRRSHSHSPMSSRRRHLGDRVSGDIGDRENPTPSRCLGVFGLSLYTSEQQINHIFSKFGPVEKVQVVIDAKTGRSRGFCFVYFESQDDAKVAKNECTGMEIDGRRIRVDFSITQRAHTPTPGIYMGKPTVSSRGDNGYDRRRDREEYYYRGGGGGGGGGGYRERDYYQRGYRHRSPSPHYRRSRRYDRDRSYSPRKSYYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHK1</accession>
    <name>A0A0N1PHK1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHK1"/>
    <dbReference type="FunCoup" id="A0A0N1PHK1">
        <property type="interactions" value="1809"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHK1"/>
    <dbReference type="InParanoid" id="A0A0N1PHK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="36963" checksum="B7FB0AAC8AACB875" modified="2015-12-09" version="1">MEDVKDLEPLEPSLRNIIDQKSLRWIFVGGKGGVGKTTCSLAVQLSKVRESVLIISTDPAHNISDAFDQKFSKVPTKVKGFDNLFAMEIDPNVGLTELPEEYFEGETEAMKLGKGVMQEIVGAFPGIDEAMSYAEVMKLVKGMNFSAVVFDTAPTGHTLRLLSFPQVVEKGLGKLMRLKSKVAPFMNQAATLFGLAELNADMFSNKMDEMLSIIRQVNAQFKDPNQTTFVCVCIAEFLSLYETERLVQELTRCGIDTHNIIVNQLLLRTSAPCELCAARHKVQEKYLEQITDLYEDFHVTKLPLLDKEVRGAAAVNSFSEYLLKPYVPPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI46</accession>
    <name>A0A0N1PI46_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460971">
        <property type="protein sequence ID" value="KPJ10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI46"/>
    <dbReference type="FunCoup" id="A0A0N1PI46">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PI46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10332">
        <property type="entry name" value="SLC6sbd-B0AT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="717" mass="79678" checksum="78DBE763339880A4" modified="2015-12-09" version="1">MANPAHLMRRQSSRDLYAQRSLDRMEMKELRGRLVTMENGHPSHRTHVMYGATNEAFEDTSPNRRSSETPTSKGSSGEERVFKPEGGECERESWDSKLTFLLATVGYAVGLGNVWRFPYLAQKNGGGAFLIPYFVMLAIEGIPIFYLELAIGQRLRKGAIGVWHQVSPYLGGIGISSAVVSFNVALYYNSIIAWCLFYFAQSFQAELPWSECPNKYFDNGSYITEPECAASSPTQYFWYRTTLQISEDINHPVSFNYKIALALVIAWILVYLCMIKGIASSGKVVYITATFPYIVLVIFFFRGITLKGMGDGLIHLFTPKWHTILDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPVDNNCYRDAIMVSMTNCLTSMFAGIVVFSIIGFKATMVYEKCLSLRNETLLETFGSSYQSMVFPEEGQPVTIDMNGNLTTVMMPHLPECDLQKELDNTASGTGLAFIIFTEAINQFPGAQFWSVLFFLMLFTLGIDSQFGTLEGVVTSIVDMKLFPNLRKEYLTGGLCLICCLLSMAFAHGSGSYIFLLFDMYSGNFPLLIIAFFECIGISYVYGVKRFADDIELMTGRRPGIYWLICWKYLSPLAMLCILISSFAELAVGGAGYDAWIASEGDTERKSWPVWAVLLVVVLVLASVLWIPGLAICSVINLSGPVCSSVKSVSYEDKTLSTVGQFSKAIVCVQTIAVLLCPVISHYLHVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIJ5</accession>
    <name>A0A0N1PIJ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460736">
        <property type="protein sequence ID" value="KPJ12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIJ5"/>
    <dbReference type="InParanoid" id="A0A0N1PIJ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="9759" checksum="9A8F9F9F988579F4" modified="2015-12-09" version="1" fragment="single">IVEDRRRHRILAEQDPGQKPRYDELRRQAQRVIRQAKRKHLEDRIKEMETLIRANESHKFYQEIRAVKKDINLPHRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIW4</accession>
    <name>A0A0N1PIW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01009701">
        <property type="protein sequence ID" value="KPJ20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIW4"/>
    <dbReference type="InParanoid" id="A0A0N1PIW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8723" checksum="EB357699E54EBCC2" modified="2015-12-09" version="1">MYECFLEIAFEAELKNINEDPECLALAFEQCNENPVTRNASIRELRELIYATSPLREDSVAPSFVPLAFEEVNRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ77</accession>
    <name>A0A0N1PJ77_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM192A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01037929">
        <property type="protein sequence ID" value="KPJ21325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ77"/>
    <dbReference type="FunCoup" id="A0A0N1PJ77">
        <property type="interactions" value="1711"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ77"/>
    <dbReference type="InParanoid" id="A0A0N1PJ77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24829" checksum="11A8C8D7B6F3A254" modified="2015-12-09" version="1">MSSGFISESEILEARRRRQEEWEKVRTEDQPKENMIRGLDDDEVGFLDLVERTKAKAAQQISLEEQKEMQEFRERVSNLAESEELIRLRAQLAPTRTPATTQPAKNKLQGVVVRKRKASEMEGDKADKVEPEKTSSPPKNGIINNSVQQNGTSETPTMATTTGDTGALRCVAILPGLGHYDTDTSSDTDDSSDFETCEKSGVKRDLLGRRPESQEKKDESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJF0</accession>
    <name>A0A0N1PJF0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJF0"/>
    <dbReference type="InParanoid" id="A0A0N1PJF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="9922" checksum="F4144B53083B3757" modified="2015-12-09" version="1">MVTKQRVYKYGVNTRYIGPLTYYYPAMGPTLPPLVYWGYPTPPVSPAHYYHPPHHPQTMMPEVVSVGGGSPLPLPPPACHEWPVFMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJQ7</accession>
    <name>A0A0N1PJQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJQ7"/>
    <dbReference type="InParanoid" id="A0A0N1PJQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="19859" checksum="D88396E47B38C3FE" modified="2015-12-09" version="1">MEEESMSGHSCSEDDISVGRPSPAPSRSPSPQDYFRPLKRLKMASEPVEERRGEGVKSFSILDILSHSPRTPPRIVRPWDASGLERLQRLQRLAGAALLDGERWRLAALGLLRPREPDCDSASERSSSASDCCSEPRRPHTSTAPHTPLDALFHMTSKTFEANSTDNGGKFLLGYVILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJQ9</accession>
    <name>A0A0N1PJQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01006750">
        <property type="protein sequence ID" value="KPJ20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJQ9"/>
    <dbReference type="InParanoid" id="A0A0N1PJQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11461" checksum="577097A48D2F7D2E" modified="2015-12-09" version="1">MIDAAAARRKEEQARIEERDKAVAANFEKLEQWKKELNAKIAKKTAEVQAAKVKNLVTCFLQKDLLVCVRDSVSVELKKNFLAYIFFQNIFYFYAKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKX5</accession>
    <name>A0A194QKX5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CW-type PWWP domain protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKX5"/>
    <dbReference type="InParanoid" id="A0A194QKX5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20145">
        <property type="entry name" value="PWWP_ZCWPW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042778">
        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999:SF2">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="388" mass="44725" checksum="41DC4FE2B712555D" modified="2016-10-05" version="1">MSKAAIIPTETAVIPREEASQPLVGLSQPQGQSHRERMLWLQRRRTEGLWASCDSCGRWRYLPHIIDRYELPDKWYCKMNPDKNLANCSDPEAPIQLHDEEDLIHSRFSAGSIVWVKLQGWPWWPAMVDDCPDTEQFYWLYGFSDIPTHYHVVFFDKLDVSRAWVSDQIIEPYTNNKNRIEDANRNKKYAKRLRVAVRQATDAFSLPLASRFSKYSFLTRYKGNIMSPTKISKTEIEKYRKSLKRKFDVDFPLNSDSDDSSSAENEPSHNKGKSVAKVMEQKKIMKKHEIKLEIDDTLANNSASSTTMYHESQVDKPNTLKETNSLKMHVSTVDDGLKNDSLDNGQSSIDAIIEINSKDTPVTDSQLEVRAASRSSDEFEFLDFPLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLL7</accession>
    <name>A0A194QLL7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLL7"/>
    <dbReference type="InParanoid" id="A0A194QLL7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="44739" checksum="33C7C603832CE038" modified="2016-10-05" version="1">MLGVTVRDKEAGAAGLFSTAVISGSSSAPNLRVMIPTAAAAANCYGGVPAIRPLETLHNALSLRQLDAFLERVTAAPVLAGTPPHATPGTSALPDTPADCTTDTTKRHSPTNSVGWSGPSSLMSSSGELPSGVSSAGPSSPTSANTDHARLPDSSYWSRNVASVVPMPQWDGEAATLCAHDAGLRALATHAHARAGSCISGDVTPVSAASDLEFNSNEATAGSGTDHDLLSAEGEDDEDTLSVDACSSPMRIIKNDLTSLSQSPASPVKVDDCEASTSKSSDLYGLSLQQTKENLYKDMPSSSKNYNNEYDVKNKCFKTENSQQWSNLNSLNLQNKDNNKPKAKINDILNNGSRRYSDSSAQRSNVSSQATGGSRFKTTLVDEEEFRASTSDSKSTDTMEQADTLAAPLVTKAKNISVKPGFSITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMP5</accession>
    <name>A0A194QMP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyruvate carboxylase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMP5"/>
    <dbReference type="FunCoup" id="A0A194QMP5">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMP5"/>
    <dbReference type="InParanoid" id="A0A194QMP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="38"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="160"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="583"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="773" mass="85737" checksum="2B8D725B21776650" modified="2016-10-05" version="1">MQILNARYALRASATQLQAWSSLRYRTATTDKTVEYKPIRSVLVANRGEIAIRVFRACTELGIRSVAIYSEQDRLQMHRQKADESYIVGKGLPPVEAYLNIPEIIRVAKENDVDAIHPGYGLLSERSDFAHAIIDAGLRFIGPSPKVVQQMGDKVAARKAAIEAKVPIVPGTDGPVTTKEEAVEFCKQHGLPVIFKAAYGGGGRGMRVVREMSEVASAFERASSEALGAFGNGSMFIERFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLDPQVRQQMVDCAVHLAKHVGYENAGTVEFLLDDKGNFYFIEVNARLQVEHTITEEVTGIDLVQSQIRVAEGMTLPELGLTQDKIRTQGYAIQCRVTTEDPANNFQPSTGRIEVFRSGEGMGIRLDSASTYAGAIISPYYDSLLVKVISHAQDLSSSAAKMNRALREFRIRGVKTNIPFLLNVLENQKFLNGAVDTYFIDENPQLFMFKVSQNRAQKILNYLGYVLVNGPATPLATNIPPSDVKPYIPPIPLDLSPEAIKRQELTGENTAVQPPKGFKQILNEGGPEAFARAVREHKGLLLMDTTFRDAHQSLLATRVRTHDLLAVSPYVAHNFSNLYALENWGGATFDVALRFLHECPWERLEDMRRLIPNIPFQMLLRGANAVGYTNYPDNAVYKFCDMAVKSGMDIFRVFDSLNYLPNLILGMDAAGKAGGVVEAAISYTGDVSDPTKKKYDLKYYLNLADELVKAGTHVLAIKDMAGLLKPRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN57</accession>
    <name>A0A194QN57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN57"/>
    <dbReference type="STRING" id="76193.A0A194QN57"/>
    <dbReference type="InParanoid" id="A0A194QN57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="54481" checksum="214464DC390428EB" modified="2016-10-05" version="1">MVASSISSPQTQFPRDLCMINATVIKHSNKKWIRHEDAPDIHRPRLDVVTLEQPGEEPRIEELIQSSNNVVANIDDITLKEPTVPEIQFLINDGFGELRSEMRSPDRTVELMLQGSSVAQLSAIDNVDVSGDKSHDKSRPHTTRELQMERINSPDNEMIVAQHPEPIVQSEAVKRKADDDIILEELEVRSPKRRRARRLIIDQHTRLGPEYMRDRIVNKKIEMRCKSASEDVINIRIPAATYLLRPAHDGHKLRPNIASVFRTLYLRNLEFISKTTTQNRELEEAVVMPAQEEPRSHLQPVEEDPSALAAVPQIELPVQTEVERAEVTMIGQGQGLLDFSDLPTQVVETLSQVRKRTSEFEYEGAKRRRSSGFLSYKQHREQLLSADIAAGMNSPYEQWGTEGTMVKVLRGVREGLALDVQHLVSLGPVLHTHRNIIMARCFTSLLKLKQHGFVNLKKDPDTLCIIDITLGPKFEEVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ64</accession>
    <name>A0A194QQ64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ64"/>
    <dbReference type="InParanoid" id="A0A194QQ64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="22691" checksum="FFC4036455B9D791" modified="2016-10-05" version="1">MIDDGPPSHGVAHALGVTPAPASVPSVDPAEGFARLRVDSDCEYLSRFVSDPLDWVSPVYADWSLDSSVLLQSQWLSEDVSCSLLPPSTGLNTLRQLLEEIDSKCTLEALVRQNNGVRVKNVSIDIKSITEEEAQRVDKMKKQMAHNQLTLQQSIKTLDIGLDNLKFWSDNYLKKYISINRTVDGKTYKEYENAYLETLSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQF7</accession>
    <name>A0A194QQF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger and BTB domain-containing protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQF7"/>
    <dbReference type="InParanoid" id="A0A194QQF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="416" mass="49021" checksum="290203629A99432A" modified="2016-10-05" version="1">MRCCAPNCKNDSRQLSKSQGITFHVFPMEQSLRTSWLKALGKESWEAKERSAVCSEHFNCDDMYETKNGLRKIKPGAVPVMKDISDEEIQNLMITLQSIQIINRECNNLESNLTTKYNNPDHYDLYIEHKEDIEEEKITEEITDIEVKNEVFLDETSLSVKEENYSSDDSLPLERRRTKKKEVKKKKRKDTNEPKIDRRRKPFLNDDLNETLFTITDLSFDEQKAEIEKRRDSSNYKNSVFKCTACFKGFLDEDAYNSHMTRHTDQCGEYECEICKTHFKHPHALRKHVTAHHTQRFSCNQCPYVTTHRQTARLHERWHKGTKYQCPHCQEEFLKFTTYMGHIRIKHPSDFVCELCGYSFVSEKGIELHKKLKHRLESDKVPDDGPFCESCNVRFISQEAYRRHLMVSAKHNTGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQQ2</accession>
    <name>A0A194QQQ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQQ2"/>
    <dbReference type="FunCoup" id="A0A194QQQ2">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQQ2"/>
    <dbReference type="InParanoid" id="A0A194QQQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="210" mass="24587" checksum="A7F94AA78CE88BE5" modified="2016-10-05" version="1">MAAPIVPNKFILEEINYFPSVVNGKLHFIGFIKASSDLLILIDRLGKIFTPVKHDIQGNIDKIKKFYKYDENSCLLELMLEEVKNGKPLGAEGVLWLNRALLFFELTFHGILDNLKSDPNEVNMKKVYMSAYEGSVKKYHGWMTQQLFNVRLYLYCNCNFHVRLCLYVFENNINVFESKLAIFNEALHLVRWEIDKFFEDNNLFTNNFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQS9</accession>
    <name>A0A194QQS9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxynucleotidyltransferase terminal-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQS9"/>
    <dbReference type="STRING" id="76193.A0A194QQS9"/>
    <dbReference type="KEGG" id="pmac:106718466"/>
    <dbReference type="InParanoid" id="A0A194QQS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="837" mass="91181" checksum="8317210E17F64714" modified="2016-10-05" version="1">MVIQKTWSNVDVANNATPTENQPASSWNFQAPVKALTNRANSTSNMQTKQPITRQIAINTLATMHRRFSLPGPVQPHSRPIAEFRASANKSLDMLRQTIQSAVTREIDQVIKKYLEKFFVPAVNNIRLNLGDESVSEDQVRAVCRAMLDATRLLYTTPSRPATTTNDTCESTNETADTRFTKQTLQSQLQIKRKEQDVDLDLNNKCKKIKQEQIVENAVSPLPAQPLRDPEKWNPARLTQDTLFIMGSHAHKVLGLGNARGRLYTRHSGLLRYPADTLDKEWIASHNLVNAVGGKTYIMVLEDIEELATSDTYKHSSLPMLGELTGFKVPPFMLRKIKAYVLKKMLSGDIGNADSPQPSTSNSTNQEDKYKVDDIKLESHDNFDSSNFNASEYMTNPDTGREYADVSNMLKEDTDFADIKVEDMDDIKVDNFKVEDLDAIKVDTIKVEDIDVNDIKVENIDDINVEGIKVEDIKLENEDAFSLCKQTDDVQNHLVDGLLEADIEFLSRNLGNIESDADARKTIEKLTGANPDTITLVGDEFDLGTTLNTDNFEGSQNTKCITVASTTSGMVHSVPVAHIATPRISGSTLHYYTSSAGPQTASRTIHHLPQATVTIQSIPGSTSQMIRGLPINTKTGTISTVMSQGTAGTIIGFGTRSSNATVLSTPAQYINVSSKSFPTGNILHNAIVSRNIVNRNNGTTTVSFTAVRTPTHTTTSKISSVLTNSSDFDTISTKDMIENATSSSVMLKKVLTLGSSGVSKSFVMHNTQKVLSTGFATGATPPPNVTIVSSGTSGGILNNNLSSPNIVCPTSGNLSATHATLSALLASNADSAQCTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRM6</accession>
    <name>A0A194QRM6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="9">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRM6"/>
    <dbReference type="FunCoup" id="A0A194QRM6">
        <property type="interactions" value="1675"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRM6"/>
    <dbReference type="KEGG" id="pmac:106718448"/>
    <dbReference type="InParanoid" id="A0A194QRM6"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443723" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="9">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="11">
        <location>
            <begin position="288"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="49110" checksum="7C511E30C7F248C3" modified="2016-10-05" version="1">MKFSLILGLAICINIAIADQETLVLVDNLNIRETHSQFFKSLQDRGYVLTFKLADDGNLLLSKYGEYLYKNLIIFSPSVVEFGGQIDTEAITKFIDDGGNVLVAGNAAAGDVYREIATECGFEMDEESAAVIDHFNYDMLDDGDHTRIVVSPKNLISAPTIVGEHNTQPLLFEGTGLILDKDNSLVLPILTADSTAYSYNPKSQVKEYPHAVGRKTVLIAALQARNNARIVFSGSMFFFSDDAFNSPVAKVHGDKVSSNLSGNKALAVHLSEWAFGERGRLRVRRVHHNREGENESSNTYTITDTVVYRIEIEELKNGKWQPFDANDVQLEFVRIDPFIRTTLKKKPNGVYEAVFKVPDVWGVYQFKVDYDRIGYTRLYHTTQVSVRPLQHTQYERFIPSAYPYYVSAFSMMVGVFLFSIVFLYYKEDTPKTKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTF0</accession>
    <name>A0A194QTF0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTF0"/>
    <dbReference type="InParanoid" id="A0A194QTF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="44" mass="4827" checksum="BCBA544A1E76C948" modified="2016-10-05" version="1">MRTSMIHTTEAAHIVRDTPAQCAATVAAQLSDLSLSFAHRTRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU77</accession>
    <name>A0A194QU77_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU77"/>
    <dbReference type="InParanoid" id="A0A194QU77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="331" mass="39038" checksum="A8F4798C1D4AA5D3" modified="2016-10-05" version="1">MNCAKLHLQKRSRSRPKSEPRHDKPRRYCQKRLVDPQFEENNRWTYETQRYNCTEYEKSNVNRILPIRNHHDVSDMFLTVQTLQFKGESQQSKRQRTSFKYKTLNSGQKHRMFVKQVVDRNVDNYDVEGASELKYYLDFSKYFSNKVPSRSSSVESRVSNQNFDKNLKRNKSVQVDFNTFAEIKQDKTSTKLEKKLNNNPEVHDKTTKDEEFTNNVKDDNPKIAFHKYGKRKSITISKAESPETVQVIRVDLVCNYSANSNTEDYNKQNNRSQIHLADVRNNDDNMRRKHYNSKYLLTKSVKALDENVSGGTNVTLLCKTFRLADRSKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUC5</accession>
    <name>A0A194QUC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein tramtrack, alpha isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUC5"/>
    <dbReference type="InParanoid" id="A0A194QUC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF81">
        <property type="entry name" value="BTB-PROTEIN-VII, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="376"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="503" mass="56126" checksum="E911EBBAEFABCCE5" modified="2016-10-05" version="1">MNIEARTVNKDNGQIMTLIIQAATEKTKESYSNYINIVLTFQLLKIARMSQQYSLRWNNHQPNFISMFTTLLNTQTLVDVTLAAEGKHLKAHKVVLSACSTYFQAVLVDNPSRHPIVILKDVSYSDLRTMVDFMYYGEVNVTEEQLPQVLDTAKLQKIKGLTEMPDSTSLTRSQGTTADFQSPGDSIDSQRHSASPAASPSNKRRRRRKSSTGSTSLNMVQEENRNDEVGQSVDLVRGDSITLSSVPQQRRMREFQDEQMDNVPQPTDQHNLHVDQLSMDNNSAIIPQGGQWSMMEHTYPRYSNACVGGGGGGTGTGNGGLQPDHGIYMNNVINPHMNDSDMNDYGQGLGVTGPSPGPSCFPEAQTAQEVVPQTQPKRRRTTNPQSEENFQRALEAVRFGGIGFCKAARMFGVNNRTLWLEYKKKGYPNNRPSIKNRIKREHTTPPPEPKEEVQQPEQQMALICPPHSVPVGFIDSRPIDFPLQGVSHHSPLNILGMNFNSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUV7</accession>
    <name>A0A194QUV7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 46 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUV7"/>
    <dbReference type="FunCoup" id="A0A194QUV7">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106717116"/>
    <dbReference type="InParanoid" id="A0A194QUV7"/>
    <dbReference type="OMA" id="NPQCQIP"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF37">
        <property type="entry name" value="GH08173P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="492" mass="55542" checksum="18CDF003E7D9C359" modified="2016-10-05" version="1">MDNCSSKDSYSVDIPRKPWYTYITVEPLMFFYMLAFMITNVIEQTFYVFKACTVNHGYSEEICYNISNYKDIKTEVQVTVSTFHQWNGIASHIVPLLLAFFIGSYSDKRGRKSILLAGLLGKLYFSIMITLNTIKAWPVEYIIYTAAFPSALTGADLSIFAGSFAYISDVSSLKNRTLRVGILDIVYLSTMPAGVALGNLLYTKVVNKSFTAMFLINTCLMLIATIYCIFALKWQTRVEQKSLREANVKNPIADFFEWNNISQTIVTLTKKRPNNRRMLLWFLLISMAFYTFQRDERPVMYLYVTNVFGWNEIDFSNFRTFLSTAYVAVMLLGIPLFTKVWNWKDTAIIMVGAAAHICGHTIYAHALTGRSLYIGATIAAFGPCVAPMIRAMTSKVLPAAERGVAFAFLSVMENAVAMFASIVYSQLYKATLKTDYVNAIFYLTIATQAIVFILASATEIALNGRRIETLIEQDETQIPTVAALNDNDQEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVC6</accession>
    <name>A0A194QVC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_15415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVC6"/>
    <dbReference type="STRING" id="76193.A0A194QVC6"/>
    <dbReference type="InParanoid" id="A0A194QVC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="564" mass="64075" checksum="2A384E5FBD6F9855" modified="2016-10-05" version="1">MMTIICIVNVRSAEITCPSECTCRTAYDAELGHILRTTCTRGDMHTIPVEFFDRSGEVIIITAPKDRPNFLTIGPIFTQPSPFVNLRELHIVNSNVPSIGQYSFWGLQHLRLINLTYNNLTSIGADNFRGLINLTHLHLDHNNIEQMPSETFRHLTSLKTLTLSNNQISTLVPRLFRMLAKLTYLDLGDNPLDDLNPEVFKDIQQLRVFKCRRCLLRRINTQIYHLVSNLEELDLGENQFKYLTSDEYISLKRLKKLRLDGNQLSVIVDNMFGRNRELKLLALGHNRLALLAPAALANLTSLVHLDISHNKIDRFHLQTFAPVVETLRTINFSGNNLPLAEIAIVLQILPEINDVGLANLSLDDIPHNFFTYNEHIVSLDLSWNKLTKFPFRLLAKAKFLQRLDLSHNKIERLEEEDLQRLEAIARVDLSKNLWRCDQCSAGTMLVYMATTVLNGTIRQLTCYSPLRLRGIKFSDLSFNVLDSCSSSHEAQMSVLAGLLLLSVAVLAAVAGALCCTRRRAAHYYTNEEKRRECDHDHPDELLNRTEVGTVATIHAPYQLVSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW84</accession>
    <name>A0A194QW84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein cycle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW84"/>
    <dbReference type="STRING" id="76193.A0A194QW84"/>
    <dbReference type="InParanoid" id="A0A194QW84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11391">
        <property type="entry name" value="bHLH_PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="204" mass="23210" checksum="D8A575C2234EB702" modified="2016-10-05" version="1">MDWPMADEWPLAPQDTCCCSCEEHKKRPAPKPPDPGGPAQAQPYLSQSLPYPIYSQSTMEVPPPSDHVSTLRGETPRDLRNKAEKQRRDKMNKAINELSKIVPPVLAMNRKVDKTSVLRLTAHYLRSHQHGQRVERSGGAKYSGSPIPDDHDQSEKTAATKKNIFLQWAKADDDDDYDGVIQEILVIHYKIFVYMICRKKRCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXR6</accession>
    <name>A0A194QXR6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase D7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXR6"/>
    <dbReference type="STRING" id="76193.A0A194QXR6"/>
    <dbReference type="InParanoid" id="A0A194QXR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF2">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D11, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17170" checksum="3D4A2D909930D8AD" modified="2016-10-05" version="1">MPNQPIKVYYYPLSPPCRAVLLTAKLLGLKVELILINIMEGEQKTPEFLKWPMLAGKEYNEEKAEKLKEVVGWLNSMLEGRKFVAGDKLSIADITTVVTMSNLDSLGFDYSSYPNVKSWFERTVKELEPYGYEEINKNNADKLATMLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ86</accession>
    <name>A0A194QZ86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Larval cuticle protein A2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ86"/>
    <dbReference type="STRING" id="76193.A0A194QZ86"/>
    <dbReference type="InParanoid" id="A0A194QZ86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="23893" checksum="1F9B8A4A4289F856" modified="2016-10-05" version="1">MVPTTVSRVAGALLCDKERCAIRNIRVNAHFYKYTQLRGTTLFTYNPNSEPMWCVIASACVIPAVVSIIVTDYPPTSTEYNYSYNVINPSTGDAKSIHEVRQGNTVTGSYSLIDPDGTRRTVKYIAGPKIGFKAVVHSEPETPYNPQIPSHSHPLVQLTPIPYVHKVLPRPIYVPVTKTINRRYFTPGPTVADKPALNEGEYFAPNKDYHSNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZP8</accession>
    <name>A0A194QZP8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZP8"/>
    <dbReference type="STRING" id="76193.A0A194QZP8"/>
    <dbReference type="KEGG" id="pmac:106715445"/>
    <dbReference type="InParanoid" id="A0A194QZP8"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="228" mass="25649" checksum="DF9038D23B1D3B0B" modified="2016-10-05" version="1">MVFNPVTHVLFDMDGLILDTEKLYTVAFQNIVSRYGKEFTFEMKLKLMGTQAHEAAQMLITALDLPMTVDEFITESKEQFQMLFPDTALMPGAKRLIEHFHKQNIPIGLATSSSEEGYHLKVDKHHSDLFSLFPHKTFGSSDPKVKRGKPYPDIFLVAAAKFPDSPKPEQCLVFEDAINGVKAARAAGMQVVMVPDPRMDRSLTKEATLVVDSLEDFQPQLFGLPPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZQ0</accession>
    <name>A0A194QZQ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_10203</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZQ0"/>
    <dbReference type="InParanoid" id="A0A194QZQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20435">
        <property type="entry name" value="Tudor_TDRD12_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="633"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="14">
        <location>
            <begin position="1359"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="16">
        <location>
            <begin position="1680"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1621"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1811"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1621"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1813"/>
            <end position="1823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1830" mass="209715" checksum="5B99F977B3273F51" modified="2016-10-05" version="1">MPPDSYLVEVLHYLNPHLIWIEVIDPSVARGDKFVFEQIGIYGVLPVELTLDVEEEDLKTRVSDEWLPAASVTIKKALAEAKEVKFCPTYIDRRSSIFDDNIHKYGELLVKKRDKKWKPLSKILIKAGIAIYDMCLFHQQLGLGKLNTRLKSSESEAVIQDIENYYLKKNVSKKNWKKSVEEKTVVSHATLELESALTTMNLQKHNDVMQQLLQNKLNDFELCKDIDEEPLGKGFKGKQQNVARETKAKEALNSNLENNLKATTLKKKLELMTKKSNSQKMDNGFKNNPKQILENTKKFLELNATKNLERKLNQEISCKNNKDQTNEMKSYYNGQTFIKGTKNITGLKLPKPISKEYPANEKRVCYGPPGILPTKLSVKVLVENVEPPLDSSTCVDNQEKTVEKEDIFANIDSGLNVEITNKNSLMSIKQNVEIHQKYTDPARFNRRESTSSKGKDSLHLTDRTDSEITVKSSSKVLQKKLMLYERKKTNFLDSSFTSCSETSNKDSSSLEDVKVRKKENKKEIRDSDDEEVVRKINEEYSIPNVSKELKCQNTNTDNNISMKNSVNPFKNIDPTISIFVEKLVTPVLMVHTKMNKRIEPVFNLRDVNFNANIQMALKTMSIESPMMLQTISWFCILRGYSTFMISPVGSGKTMGYLPAVCRLVSDIDSDDIESVGPKSIIICATAKSVGQVEKMSKMFLNVNNKVVTCFAGVDDALITTSLLNGCDILICTPSYLVRLLQVTDFGVDLRRLATVVLDDCERLGEVYINELKYIMLRIKETLKNRANKELRVQYVVASRIWCDFMEPIVKKAPYSVVCIGAFQECVLYSKTGMSVSFVYDNTKMQAVHDFLTQIDVTKRIVIICDTDDEIFLLKNALRKYKNPVFTCDSSMTIQDLYNLRITWDEYEEPLLGPILLCCNDTLAHMNVTDAYYLLIYSLPPLFSTFCRWFSVLNDKYPSIFKSDNDIVKIKILIEEKNVEQLPKMLNFIRRCTDNTFPQHLNVICKNIMVEKDKAKASKLVPLCNNLLGLGYCPDYWNCHFRHSFVEDVDNMKEWMPLTGQVTFKILHYHSAVCYSARLLSNTVKDSTKKYPQTYSTLSLKMGMYYSKESNKKPHGIPKIGDICAVSLKQNFFARCQVIKILSTYQRGNPNSVLIKLLDEEKIETTRDIYLYYIPEELKKIETHVVQVRLANIQPKDKDVTYSDLARDQLKRITDKDEELYMRGEVAMSIGNCVFVDTLEACQDLASINQTVVKHDFKSDLLEKHAVPNMEHLDKIKKLCDDKFEVKVKTQTRKSLESTKPKTIGSWAHLDKDNMSLVFFGCALSPSKFFVRLQKFESCLNMLLKEIQKFVAENPKPLSHVEEGDIVLAMFPDDETFERARIDSIIDNNKVKCFFVDQGDWREVSTKKIIAMKEEFISKLPFQAIECRLLGVTPAGEEWTDFATNWFSNICFDVDTDNMKSLYVKCFTKEKAEFTGGNKYGIVMIDTNSDDDIVINQVLIDVNLAKENESEMKYLDKCETINVSKNSSKSDQLSDSEVEEVEDNESFPMCKTGNVKANNMSTLDTIFKQPIRSVPLVGSDDSDDSDRWHINMAEDFFKLFKPNTNDSKIKDVKNLSAIMNGTEKDVNTSDDKPENSLPKLSQIQNNTKELDSDDYTSPESSDVLNTPDKRVIKSLLVTDNMRKPKVIWRQNKKFVFIKVNLIGLQMYDVKIEGRAISFAANLNDVDYAFDIELYGAIDVVKSQHWNKGQYILMKLHKILNKNWLTLTKDGEIRKWIVYDVESIDVSSDEDIIEEHSKKAMLSAIQNIYNKQETESEDDDFDDDLNYGYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0C2</accession>
    <name>A0A194R0C2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0C2"/>
    <dbReference type="FunCoup" id="A0A194R0C2">
        <property type="interactions" value="1737"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0C2"/>
    <dbReference type="InParanoid" id="A0A194R0C2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20788">
        <property type="entry name" value="TBC1D23_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="269"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="13">
        <location>
            <begin position="561"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="913" mass="102871" checksum="50DDCB81B50C53ED" modified="2016-10-05" version="1">MGNAGSNQPKEWHKDNISKQLDAPSSPSKEGEAFTFDKRTDDDPTGREDDNNIEDGAPYYTKAVPESNVEYQETSDLPTTLTDSSNIVDDIKVLPTVFKWEGGGKQVYISGTFTDWKTIPMVKSHGDFVTIIDLPEGEHQYKYFVDGEWRHDPTVKVIDNGMGSKNNLVTVKLSDFEVFQALAKDSEGIHSGAQTEYSQEIPQSKPWEKVTGPPILPPHLLQVILNKDTPLSHPAAVTVLSNAELIELESALLDGCSPQEINVITKGKKIPDSLRPDVWLVCLNCQDGVNQLLLFDEIFDLPNQNELRDDVKKFVQRLDNEDEEKLAVISDIESIITFYCKSKSISYSSNNGWIEILYPLLSLKLPRSDTYNLFEKIIKLYIPKGCITNGVPFHILRLVLQYHDPELCSFLDTKRITPEQYCLPWLRSLFAGTCNLEVVLFMWDLYFQRSDPFFIFFLCLIMIVNAREQLLQMKTEEKSTIIKTLVGMPGDLEANDVSDFCSLAHYYSLKTPQSFREDVLEVLFSESGLEINSKLYSQALCLPVAVHELIESATVDAADVDSVKFFLVDCRPAEQYNAGHLSTAFHLDCNLMLQEPNAFNTAVQGLLNAQRHALAAGSLAAGEHLCFVGSGRTEEDSYAHMVVASFLKKNTKHVSMLDGGFVAIHDYFGPHMTDCLEEHNISTCLVCAPNNNNVNNEPRKAKVRENVPAIQLFSKLSSAMKAKSQEVKGKLIEYIVNPNANVNNGEWHVSANDRKDHRYRNVPPVFSINDEDDDSHSDSRRDIMSSDALEEIVELQTFLKGHNVIDNFQCQEVLLNGYMYDSYLIVTDTHLIILREIPNKRGFAKILSRRPLSTIVKITAKKRHPELITFKYGIPNGDDLLIKDMDRFLIPNASVATKVVSNQIVLQLDNKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0L5</accession>
    <name>A0A194R0L5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0L5"/>
    <dbReference type="InParanoid" id="A0A194R0L5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264806" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="17837" checksum="8C0CB2580643EFD9" modified="2016-10-05" version="1">MAYFFLIATIVLVVGVNADPSNDNQNPFQGFPFDQTPPINLSKLPKIDLPKLPDINIPGIINIKGVQLPSIDFSQLPDIPESEMPVMPPMPLFFPQIHITSFNNDNLKRIKPGPNQHFVGSSSSSFTVSSNVNGRKNYAGATKTIVNNNGHVDEQALIIENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1E2</accession>
    <name>A0A194R1E2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metalloproteinase nas-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1E2"/>
    <dbReference type="InParanoid" id="A0A194R1E2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="26812" checksum="C453F27FA887F09E" modified="2016-10-05" version="1">MGVRQISYDHVIAMRLRLAMNLLESVSCMKFIPIIGTPNRNGSWLHISNPRLQRDCMHEPLYKGNGELHWLSLLKFIPIIGTPNRNGSWLHISNPRLQRDCMHEPLYNGNGELVLVLGLDCLHEQQILHTLLHGVGFKDEVSHPQRDQYIRILWSNIHPAYQHLFKIRPRAKMSSMIEYDPMSVMHFHDRAFSTNGQATIVPLIAGLVITPSDSLSQLDKMKLKLRFGHECNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1V1</accession>
    <name>A0A194R1V1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1V1"/>
    <dbReference type="FunCoup" id="A0A194R1V1">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1V1"/>
    <dbReference type="InParanoid" id="A0A194R1V1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="280"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="56089" checksum="9453127F4F60A16F" modified="2016-10-05" version="1">MQHGYRIPEEEGSYYMVRFWRGEPFTYPKLCLTQNFPIITPLPKSAEEPVLSRFLTSLKTKMPYFLGKPLVVKFDSENRNISASDLKLDIQDPQEILTPEEYKCWLENQEAMYILEIERIEISNKEENDKWEKAEKVAIENWRKLQEKNEQLRLKHLQEIAKRKLEWEMEKKRREEEAERLKEIEEENKRKQKIFMEKLEQFLKGDSEDPPEELLVSRESRPNTNLCPFFLKTACCRFGDECSRNHQYPGISKVLLATNFYSHFGLENSNFNEYDTDLMLEYDDKDTYKHFEEFFNDVLPEFEKYGKVVQLKVCNNYEKHLRGNTYVEFRDLRSAVAAYQGLHSRWYGGRQLSLQFCKIKSWENAICGLHPQRRCPKGRGCNYLHVFRNPKDLFSGYNSHRNRQRRTPPRSWRWSESPERDPSPKRRRSRSRNSRQDDEGRSSRHHNEKDRDIPRKRKSRRDSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R291</accession>
    <name>A0A194R291_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor coreceptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R291"/>
    <dbReference type="FunCoup" id="A0A194R291">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R291"/>
    <dbReference type="InParanoid" id="A0A194R291"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF9">
        <property type="entry name" value="ODORANT RECEPTOR CORECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0085">Behavior</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="476" mass="54138" checksum="4193EFCFAB92FDC4" modified="2016-10-05" version="1" fragment="single">LQMMTKIKTQGLVSDLMPNIKLMQMFGHFLFNYYPENGGMSTLLRKIYASVHAFLIIIQYLCMMANMAQYSDEVNELTANTITVLFFAHSIIKLIFFAFNSKSFYRTLAMWNQSNSHPLFTESDARYHQLALTKMRRLLYFIFGMTVLSVVCWVTITFFGESVRLITNKETNETLTEPAPRLPVKAWYPFNAMNGTMYVVAFIFQVYWLLFSMAIANLLDVMFCSWLIFACEQLQHLKAIMKPLMELSASLDTYRPNTAELFRVSNTEKSEKIPDTVDLDIRGIYSTQQDFGMTARGAGGRLQTFGQPAPNNPNGLTQKQELLARSAIKYWVERHKHVVRLVASIGDTYGTALLFHMLVSTITLTLLAYQATKIDGLNVYAFSTVGYLSYTLGQVFHFCIFGNRLIEESSSVMEAAYSCQWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2W9</accession>
    <name>A0A194R2W9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2W9"/>
    <dbReference type="STRING" id="76193.A0A194R2W9"/>
    <dbReference type="KEGG" id="pmac:106714105"/>
    <dbReference type="InParanoid" id="A0A194R2W9"/>
    <dbReference type="OrthoDB" id="6624538at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264878" evidence="2">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="18971" checksum="7822FABFF908BA5B" modified="2016-10-05" version="1">MNASHALRFSCILTLFLLSLAYCSASEHDSSQKDDINVKRVEVYDGVYVSVPKGNQTDKLVSFEIKTQDDSVFETGRGKKIKSKKLLERLLPMFIMPFLIQSAIVPFFLSMLKFMLFKSLMVGKLAIGLILLNAFKNSNSFKGRDDEIANVHYGYHGNGMHEYGAYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R323</accession>
    <name>A0A194R323_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Plexin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_09856</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R323">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R323"/>
    <dbReference type="KEGG" id="pmac:106714270"/>
    <dbReference type="InParanoid" id="A0A194R323"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097374">
        <property type="term" value="P:sensory neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12205">
        <property type="entry name" value="RasGAP_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000027">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000213">
        <property type="entry name" value="Plexin A4, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000203">
        <property type="entry name" value="Plexin B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000728">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000868">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264877" evidence="17">
        <location>
            <begin position="22"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="18">
        <location>
            <begin position="15"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1894" mass="212667" checksum="1E3A5436DCD87ACA" modified="2016-10-05" version="1">MATSLTVLVITFWLRCTIVYGYEFISQYPIHHNETFKFYHLVVDKISGQVYVGSVNWLHQLSPDLKPIHVIRTGPKLDNPLCHASGCPSSDIQTTWIDNVNKILVIDQESRIVIACGSVSQGSCLKYKLGDISAEPEFVPVSVAANDPEASTYAFIGPERYNSWDRSNVLYVGTTFTNNGEYRHDVPAISSRDLMSLELAQFTFSKQSLVQIDVKYRDNFLVQYVYGFNVSDYAYFLIIQKHSHLAGNEELGYVSRLARTCVNDDNYNSYTEVTLECHVKEGTINDKIEIVNYNLVQDAKIANAGVKLANQLGIETGDPILVATFSPSKGISNEPVNKSAICVFSLQEIEVKFNENVHMCFNGSTKARNMGYISGMISDGKCPSVGSTGNILNFCEVGLKISGLYPIKTMSVISWNDTLISSITMSVTGLHTIAFLGTSDGILKKVLIDAEQSSEYSSEIILPGQKILPDTTLSPYQKTLYVLARNTIVQIPTEKCAEHGNCSSCLESNDPHCGWCSLEKRCTVQSMCQKGTQSAPRWLSQYTGQQCIDFEQILPERISINEITTVQLVIRTLPELPFGAKYKCVFGNAPPIDAAVTSNGLACPTPDIKHRPKITQGQDHVYVPLSVHSSETNKDFVSRNFAFYDCGQHITCHTCIMSEWACNWCIYDNKCTHDVSVCQRTIISGENNPTKLLNHGIGHCPRIRQYKKPILLPNNVPKELELEVENLPHLQPGHTGFQCSVSIEVANMILPARVESNHFIVCDKTTYSYEEDVGEYNVSVKVVWNHNHYIDTINITLYKCEILGSHRDHADCSLCITRNSIYQCTWCGNSCSYSESCLENPVTECPKPRIDMIKPLSGPIEGGTIVTIEGSNLGLRVEEVTGKVRIGDVLCDIVDFEVSVSITCRTGPSNGSVVAPVIVQNDAGHTESSVLFSYKNIKLQGIYPGLGPMSGGTQLAIGGQHLNIGSAVSAFLDELPCAVNKTQTSNSRLICVTPKANTPRVIHTLTVVIDNANRTLYGDLFNYTADPTIMEIKPLKSFVSGGRMITVHGTNLHTIQKPLMKLYYGNEISPINFTACVVLNSNQMECPSPAVNKKYDEILLATKSQTSTPQIAMKVGFVMDNVETMHDLEKYFNPPRTYMVFVEDPHVYQFPSRIKSYKGDPLVIEGENLIRASDESDVVVTIGTQPCNVTSLTMQQLLCTPPEIQPSNTDENGVQISDINLPLVVVKVGKNLRFPIGYLHYELLRNYNFPPEAIAGIAAGTFFLVLIFMIVLVMYRRRSTKAEREYKRIQIQMDTLESNVRLECKLAFAELQTDMSDLAADLEHSGIPTLDHVNYVMKVFFPGVSDHPILNVQRQFINTPRTNYDAAMIQFEQLLNNKCFLLSFIDTLEAQKSFNIRDKVNVASLLMIILMGKMEYATDILKSLLLRLIEKSVCNKHPQLMLRRTESVVEKMLTNWMALCMYYYLKDYAGSSLFLLFKAIKHQIEKGVVDAITHEARYSLSEEKLLKEQIDYQMVTLHVIQDDFDDKIQCKVLDCDSISQVKSKILDSLFKNTPFSMRPSVHEVDLEWRHGRGGHVTLQDEDVTTKTLNGWRKLNTLAHYGVKESAIMSLIPRQNDSFNTPYKIPCKNCTGIYCSNSHIRVYNSDITDQNVHFYHLVKPIEYQHIINKSSEHSHKAIPEIFLTRLLSTKGTVHKFVDDFFSTILTVNEVLPPAVKWLFDLFDDAARAHGIINPEVVHAWKSNSLPLRFWVNLIKNPDFIFDINKTATVDSSLSVIAQTFMDACSLSEHRLCKDSPSNKLLFAKDLPTYRDMVIQFYQAVSQLPQVSDQELSTSMQQLSVEQLNEFDTLSALKELYIYVSKYREQIMLGLENKMHLAHKLDNIACTMEGDPTSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4V6</accession>
    <name>A0A194R4V6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chorion class CB protein PC404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chorion protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4V6"/>
    <dbReference type="InParanoid" id="A0A194R4V6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="223" mass="21501" checksum="AE038B53F57BB76D" modified="2016-10-05" version="1">MLGNGLASGHPLGPGNPLAANNIAAANIAASNLAATSNIAANNIATANNIATANNVATANMAAANNLAVANTLAVTEATLPVAAHPLGYEPKLAGLQIGDIAASNSRGFQVTSSSPGAPHGLSVLSENLLVEGPLAVTGQLPFLGSVSLEGPLAATGQGAVSYGCGNGNVGMVNENTGPVGPMPGMPYGGVPMGPGFGGNGFGFNNFAAGIPNEVGTVNPIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5H2</accession>
    <name>A0A194R5H2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetraspanin-31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5H2"/>
    <dbReference type="FunCoup" id="A0A194R5H2">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5H2"/>
    <dbReference type="KEGG" id="pmac:106714865"/>
    <dbReference type="InParanoid" id="A0A194R5H2"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="25365" checksum="FBF0E0E5D7BA06DB" modified="2016-10-05" version="1">MCGGFTCSKNALIALNVLYVVVASILISVAVYGQASSLVTNLPIVGGILACGVFLILISLLGLAGAVKHHQVMLFFYMVILFLLFLVQFSVACACLAVNSDQQEMLAQQGWNKVNMDVKEQVQERFQCCGFQDRLIPANGTADYPSCDIVDRICCKNMVISPHCQCEPCMETLKERIDYAFKLCGGIGLFFSFTELFAVWLARRYRNQPDPSYKEPHAIFPRKNYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7G8</accession>
    <name>A0A194R7G8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysosomal acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7G8"/>
    <dbReference type="STRING" id="76193.A0A194R7G8"/>
    <dbReference type="InParanoid" id="A0A194R7G8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF19">
        <property type="entry name" value="GH19849P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="327" mass="38239" checksum="3027667BDB95C9D0" modified="2016-10-05" version="1" fragment="single">LFRHGARTPISSYKSDPFKNYQWPDGLGSLTNAGKLQLYELGKKYRNYYANFIPEEYYEKDVYVKSSDKSRCLMSAYTFLAGLYPPSDRQTWHPELPWQPIPVHSLPKDLDNLFRHGARTPVTSYKSDPFKNYQWPDGLGSLTNAGKLQLYELGKKYRNYYANFIPEEYYEKDVYVKSSDKSRCLMSAYTFLAGLYPPSDRQTWHPELPWQPIPVHSLPKDLDNIVAQTKPCKVWKSMYEELLEEANADPKFSELFDYLSKHTNQSMRSVLDVDFLYSTLQTQQEAGLKLPDWTKNVFPNKMRTPFMLSLALLSYNQTLQRLKIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7Q5</accession>
    <name>A0A194R7Q5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative cation-transporting ATPase 13A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09838</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7Q5"/>
    <dbReference type="FunCoup" id="A0A194R7Q5">
        <property type="interactions" value="2087"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7Q5"/>
    <dbReference type="InParanoid" id="A0A194R7Q5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000098">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="256"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="841"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="932" mass="104538" checksum="6FD690F2645FE354" modified="2016-10-05" version="1">MQSSLDDLVQYTQLFKPIATVLQGTILPFLVIYPVVFYFWVVVYGFEENFEAGFVTVAAVAIIQILICLCCYWSVHIQCFLSCTAVKDPIQAEIVKVVPTSNNGFAEIVKLHHTKSTTKGSLNPDVWFIFQKSKYVYDWEKEMFHTIAFPANKKYEDYMESKGYLDDESIDIAEKTYGKNEMIMVVPEFMELFKERATAPFFVFQVFCVALWCLDKYWYYSIFTLVMLVMFECTLVQQQLRNMAEIRKMGNKPYNINVYRNKRWRQIMSDQLLPGDIVSLTRSHSDNLVPCDILLLRGSCIVDESMLTGESVPQMKEALDNEKNLKVNLDPEGEGKLHMLFGGTKIVQHSSPSKNITSGLKAPDNGCIGYVIRNGFNTSQGKLLRTILFGVKRVTANNLETFGFILFLLIFAIAAAGYVWIKGCEDPERNRYKLFLECTLILTSVVPPELPIELSLAVNTSLLSLSKLAVFCTEPFRIPFAGKVEICCFDKTGTLTSDNLVVEGVAGIAGHTDATVIPLSEAPIETIQVLASCHSLVQLDDGVVGDPLEKATLKAAEWNLTKGDAVVPKKGKSPGFKIVHRNHFSSALKRMSVIAGYQINERGFIETHYISSVKGAPETIKTMLKEVPSHYDHVYLTLSRRGARVLALGYRSLGKLTSQEIRDLSREDIECDLTFVGFVIISCPLKSDSKKAIAEIVHASHSVVMITGDNPLTACHVAKELKFTQKSEVLILSEVNDDWAWKSIDDNVVLPINNKSEKELIKKYDLCITGEGLTFLNEHYHELMIKLMPHIKVFARFAPKQKEFVIITLKSLGFVTLMCGDGTNDVGALKHADVGVAILANAPERAREKPREERGQEPEPPRRLPGPRTDARAEARAEAAARLRRAMKKLEEEDQPQLVRLGDASVAAPFTSRLSSILCRKKDDLLDNFITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7V9</accession>
    <name>A0A194R7V9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein ultraspiracle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7V9"/>
    <dbReference type="FunCoup" id="A0A194R7V9">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7V9"/>
    <dbReference type="InParanoid" id="A0A194R7V9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="98"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="40927" checksum="B2DFA9C9FEDA4270" modified="2016-10-05" version="1">MCEKTEAVEICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREERNCIIDKRQRNRCQFCRYQKCLACGMKREAVQEERQRAARGAEDAHPSSSVQELSIERLLEMESLVADPSEEFQFLRVGPESNVPPRYRAPVSSLCQIGNKQIAALVVWARDIPHFSQLELEDQVLLIKGSWNELLLFAIAWRSMEYLEDERENMDGTRSAATPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPDVRGLKCRQEVDLLREKMFSCLDEYCRRSHSAEEGRFASLLLRLPALRSISLKSFESLFFFHLVAEANISGYIREALRNHAPPIDTNSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8C2</accession>
    <name>A0A194R8C2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sperm microtubule inner protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8C2"/>
    <dbReference type="STRING" id="76193.A0A194R8C2"/>
    <dbReference type="KEGG" id="pmac:106712146"/>
    <dbReference type="InParanoid" id="A0A194R8C2"/>
    <dbReference type="OrthoDB" id="410807at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054323">
        <property type="entry name" value="SPMIP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826:SF1">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22589">
        <property type="entry name" value="SPMIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sperm microtubule inner protein 1 C-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="26494" checksum="98A3121E96092A2D" modified="2016-10-05" version="1">MPLLDITNPAVIIFLIENYEKENRLRLNWIHKHREQIQQAATLNREPTNYYETDVIAHNMIAGMATTTRDHIVSGYNRRKTPLRDAVFVPGVKDLRHGHSIVDVGLGDPKDDSRLKRADDDLSIDPIMRPVDPKLNKIIYKPRPEFGRNRYLETRSKTWPEKKYYFSECSNWDYGWRMKDSSLHQKPLYGRCWHLHRAVRTRVGPQPDPPYYKSSDPPGPTKFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAD3</accession>
    <name>A0A194RAD3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAD3"/>
    <dbReference type="KEGG" id="pmac:106711707"/>
    <dbReference type="InParanoid" id="A0A194RAD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265043" description="Cuticular protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="13489" checksum="55F077E6C254559D" modified="2016-10-05" version="1">MQGFIVFTALLACAAAAPGLLLAHETPVVAAVHAAPVVHAAVPVVGAKTTITKSSQVVHHGAVVAPVVVKTAVPVVHAAPVVTAVHTPVVHAVHTPVVHAVHTPVVIKTAPAAIAHSSSVVHHGAVVKAVPLVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAI9</accession>
    <name>A0A194RAI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAI9"/>
    <dbReference type="STRING" id="76193.A0A194RAI9"/>
    <dbReference type="InParanoid" id="A0A194RAI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="416" mass="45755" checksum="5CBD8970BE29B68A" modified="2016-10-05" version="1">MKFTVDVLGVFLKVVIKVSFVINTLAWERERLCPAAPQSGRDAPLLKINRETFAPLVVSALFIVLTSLLAHAARSAARRLVKDAFLRLLLEEAIAAAELCGCCFELIIVADNFGVATYAVFLFVLTCWWALSWGEATACPYTHLEDVIEGKCDIRAALLKTWAELGGGLLVFKYVQMYWALEISDTHKDRAYQECTADLQVPALYGAVVEGAATCLCRLTSRALADLSPRFATAIDAFIGTSLVVAGVVARDAVLEYRYEDTAPDADLSVSLLCKVHLGKVQLQTTEIKCAVPIEIVTQKVVPLKLARSPAIIPMIPDKEPIIPPSRREGNRRHTGTAMVFDMGSISPAGIRGTGTKQHCSDWTKQWQGLRSQNPSADVACVLLRQGGFPNTKILRLDTVRDDSRLLYFVIFKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB57</accession>
    <name>A0A194RB57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB57"/>
    <dbReference type="STRING" id="76193.A0A194RB57"/>
    <dbReference type="InParanoid" id="A0A194RB57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="532" mass="60918" checksum="D84F484CD5FC16BB" modified="2016-10-05" version="1">MPPVFHLDRYELCIDQTGGIYCIAEIDLVSDSDNDLLKMIHEYSARKETHFNHSRLHYGICLTKMCKDYLKPNTTSSKDLNLVIEKCLNTSFWEQYKLKTRIKEDTKCHTQEQYYPIEPIDIVVAVILLSIFILNLAGSVYDILIVKKNNSASSCMFNRLTPPYAAVLAISATWLRFAGSGPFWEIVSSSEDKLELISIANFQKKQSPLMKRIINDFNNYVPKVVDESLAKMTFVKSSDMKDRIKKASEYYTVGRNPVQGEFMLFAFESMNKDLKITDELVHQLQVVVTTVEMVQSYFFFWDDLEDNSLTRLNKPCWHLVDNIGMMAFNDACILRSYIDEVLRQNFNLEMRDKIMNAYHQLYFNAAMGQHFDAEVARSRNYDNYTMETYDMICLLKSSSYAIKSPLTLALILSNKWNKESIDIVENLAVDIGILIQCHNDLIDYYNTKGKVTGKSGSDIQTGKCSWVAAAVLENCSAAQRRIFIENYGNTDPEKGIVMGNSTKIVNLQNSSQFTCVKQIREPVRSSAQFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBA3</accession>
    <name>A0A194RBA3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBA3"/>
    <dbReference type="InParanoid" id="A0A194RBA3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027967">
        <property type="entry name" value="DUF4612"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14974">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 1700025G04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14974:SF3">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 1700025G04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15389">
        <property type="entry name" value="DUF4612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="578" mass="63950" checksum="44AF357F34206183" modified="2016-10-05" version="1">MLYAGAADKEADEEEGSAAAAPAEDAEDAAERADRARNILPLSAHPPPIEVSASQQDFFKMLDEKIENGKDYDSSSETEVRLEQERRRMLIEKWRSASQSTQSSQSQPSPPTPARRRVSRPMPQPPERQNSPGAVRRCYRQQHVPEGMSPPPRRAHSAQSHHPPDSRPINGDNWHDPSKSPVKRPQSAGANWKSNPKVAPYNQKTKKTETNEHQRASQKEIECEISTETSQITYNPTFQSHSPAHSAKGQQPYIAQIVSYPKSQQVNPPSPPKFIAPPEEYQDPQNNVDNKYNNVQKPVPTTQPNNQGNIYYIHGNTAAGFSQDIVHQRQQTAIHLQQYVAMKQAQQQMYTYFQRGPHTIFPNVDFTQTPRMYEGEEFSVQYGHPAMRPHSAPTPVGVVRPMPVAPGFKPLPDGTHMVQMPMWTHMPPVVSTMPWVPGQVPHEMQYYPQSQYFPMYRAHSAGSAGTLTRYHKKEVCEGDVKNVCQSINVVRQKVVGQIVSVASQGPGLGQELTVCSSASDSPSPASVSTDSGVSPGNSAPSSKTSVFSSDTAAAIDKSKKKSIPLNARSLKNSKSLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC82</accession>
    <name>A0A194RC82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC82"/>
    <dbReference type="FunCoup" id="A0A194RC82">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC82"/>
    <dbReference type="InParanoid" id="A0A194RC82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000028">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="262" mass="28384" checksum="FB3A6D97C271F491" modified="2016-10-05" version="1">MVIRFVTADGGLAIDVDTRRHPPTPATPPETLASLSRLHPQHSGPQHLHLPLIVTQAVGFLSIVYTIVRLTPVIALICGLLVVVLMVLGLASADWLMAAGWRQGLFMHCIDPDAPTPLPFDIVAQPGCYAARPASYIKAAAGLCVATLAADVCGALLTGLGLRSADHRTKFRYYRFAVLAMALALMCILIALVIYPVCFAAELNLGNRSVWEFGWAYGVGWGAAIFLFGAVVLLLCDKESEELYYKERKVSTNNTNTYDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCC7</accession>
    <name>A0A194RCC7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCC7"/>
    <dbReference type="FunCoup" id="A0A194RCC7">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCC7"/>
    <dbReference type="InParanoid" id="A0A194RCC7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="14"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="370"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="683"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="817" mass="93893" checksum="F8BCE3417111C2CF" modified="2016-10-05" version="1">MTSEKGGRKEKNQNIQVFVRLRPLNQRERDIRSLGVVEVVNGREVVVRQSQQTAHTKRFTFDRAFGPNTKQVEVYQEVVSPLIEEVLAGYNCTVFAYGQTGTGKTHTMVGENTGNETTWQDDPLAGIIPRALSQLFDELRLTNTEYTVRVSYLELYNEELFDLLSTSEDNSKLRIYEDVTRKGSNIVNGLEEITSMFYICAKFHQDLYSGYGDIFKQTSIHPSKHSHLYYYRSHTVFTIVIHMKENSPEGEELVKIGKLNLVDLAGSENISKAGSDNPAKRERARECVNINQSLLTLGRVITALVERHPHIPYRESKLTRILQESLGGRTKTSIIATVSPGHKDLEETMSTLEYANRAKNIQNKPEINQKMTKKAILKEYAEEIDRLKRDLQAARDKNGVYLANETFTEIMLKQEEQRKDIQELLLRKRSVEEERERIESMFNSQGQELQRQQMELNITKNILNSTKDKLDETKNMLHSSQQEVEEQKHLVSCHQRTESGLSARAADILAVADMAPHMYTVYMITLINAKSHTAESLQTCADNRVRLQRLISQATETMNKMSSVQSELSAELHSSSSEQQREVREVLQTHAGLLQATLQRAAGTATGALLTAAHLDLQTPLATYLNQWYTSMCASLSALRSGQTQFAQCVQGGAQTQMLSARRQRAARREHADRTNAAINARIALIMEDKANIERQINEQLEDIKRERTEMELRLTEWMEEERRILEERIAKHVKKERIALEERLKSRLSKIEEQRRKMEENISHNLEWHEALLRLNEQESGELDVDMKENEKEVEKCLKEVENFKQDYLPYTSHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCS7</accession>
    <name>A0A194RCS7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCS7"/>
    <dbReference type="InParanoid" id="A0A194RCS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="20118" checksum="53290D72F035D1D9" modified="2016-10-05" version="1">MESAIIDNENKDQDHGNSSKVRTDLLEYMTRNDGSVLCKLCGEILQSRTHWYRHKYKAHAMPPLNPAPLFQCEQCLVFFKSRKGYIGHLASRHSEVLADSSPVLTNSQAEALAKQAQTQTEESDNQENQADWEERRTREEKLVADIIDRVRRECEAQGSGGPARRGYTRRTTVMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDR7</accession>
    <name>A0A194RDR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDR7"/>
    <dbReference type="STRING" id="76193.A0A194RDR7"/>
    <dbReference type="InParanoid" id="A0A194RDR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="15375" checksum="3A294C5796B6B23B" modified="2016-10-05" version="1">MDGWMDVCLLEVEDFVDQLLSKEAAESPSDVKTADNLILTLPKWYDEEKFNHSWESVYKVRRRHILMSKAAMLKGQGIICQRDLALTLFGFIGFTFLKPEKFGVETLEKDDWEAYNQFWRVIGYMIGIEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REB1</accession>
    <name>A0A194REB1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39S ribosomal protein L1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REB1"/>
    <dbReference type="FunCoup" id="A0A194REB1">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REB1"/>
    <dbReference type="InParanoid" id="A0A194REB1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="29145" checksum="D57EB32EBC3EEFFE" modified="2016-10-05" version="1">MRYYRWVVYTAEDAVKAHQETHHPTMYNFPDALVCAKVEMNMEAVKKNRYMDSFTRLTLLPHSFPRDEERTILAFCKGPELIKQALEAGATTVGANEIVKKIQDGEIKLADYDFVIAHPNMITELVPIRGLMKRRFPNVRNGTLDPNICDLVKKFAAGIQYRVTKDEKQENFGSVEVPVGRLNMDAKQVAENIDAFLKDIQSVRPKRDGLFITRCFIVSPPSTEVLKIDPFVHVDRTLSKEVQEDSDDEGEAVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REU0</accession>
    <name>A0A194REU0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tropomyosin-1, isoforms 9A/A/B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REU0"/>
    <dbReference type="STRING" id="76193.A0A194REU0"/>
    <dbReference type="InParanoid" id="A0A194REU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="23449" checksum="249D38C544B35886" modified="2016-10-05" version="1">MTTNMQQGTILDVLKKKMRQTKEEMEKYKDECEEYHKRLQVEIMRREEAESEVAALNRRIQLLEEDLERSEERLATATAKLAEASQAADESERIRKALENRTNMEDDRVAILEAQLSQAKLIAEESDKKYEEVCVMAFSARKVLENRSLADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFF8</accession>
    <name>A0A194RFF8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFF8"/>
    <dbReference type="FunCoup" id="A0A194RFF8">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFF8"/>
    <dbReference type="InParanoid" id="A0A194RFF8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265144" description="Cilia- and flagella-associated protein 157" evidence="9">
        <location>
            <begin position="27"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="952"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="558"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="747"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1145" mass="128396" checksum="A3304AA429FC4EA5" modified="2016-10-05" version="1">MSCLCQQQMCCCVRHVATHLLHFCLALSAQSPQMILHFKYHTSRNRAKERYQRSAATARARRADGPMTQHAPRDHRRFTAASPRRSLNASHRTSRFNCLNLSPGGASFANPYGGEERVDLGQVWVDIPSSLVALGGDVHITVRGAPAAAAAALRVRLAREDDGRALLATMPLALDAESRMTLPCGYFSRGGTYYLELVAEGEHLPAEDYEADATERTTEEGERVRRAADGDTVQTGEGAVKSWQFEVQWPTATLDVTPERIQTYPERAVTAIVEFPRAVCAPLRAGADFWLELLYCGHASGGAVLCDGRNTSSHAHVLYSEQMHAFPGRRTMTLRCELFGQAGDYALTLRPAAPAAPAGSQDLAAAFIKADWSEQFVLNVRGGSVLPCGAGVRVLFQYPECVLERADRVRVFGRDRDRLRYVAERRVTRGQHTASFDCRLFSERFPEYCFVYVSQAVTGAVADVRMDCLPTLPLSEGGAGAWGAWSAWSACPAPAHCSTRTRSRHRFCDSPPPAYGAKYCESEIMPPKKEKGKKQKQEEAPAAPTVTETEKTFFELEIADCNRKVARLRASIEEYEIRNEELQKAYDKLDEDRADIIAYLKKVLNTKNEENVELKEKVKGLEEIREIETANFKKTVSELERNFTVMKEQLTSENKLLAGKLNTLEEFRCIRDDLMRKYEKQEQDFKDQEMKYKRIIYDAEKKFVIGKDKLKKEMEGRLLQLAQDFQDATELRVAASTHRVIRENIAINNELDNILSAQSKLTDLNEKYRESERNARISMELAEEERDKAINRSIVQKKVIDQLTAAFQNINKEKALFEKRNYDFETLQAKIQKLTKENENQLLQIRILEQNLHAKMTDENKSIVETSKVNKENAKLKKILKEAATAIQAALKLDEWATTDKSRDIMNRELLLSRLLSIINQYRELHKADSTDTFASLSKIYEEGDLGFVPKPSSKKSMGSTVALTSSRETLPAEKESALSMAVSTSTIGSIKTIPSMKLVPPSSAQDVTVKQSVASFVTSSHSSDTSRSSEEEKEEESDDIEAQLVKSKLEIQKSIMKDLASQRRLSSRARLSEEKQKALMSKSVIFEEKEDESVEGEGKSQVGDSETATGEAEGEGEGLEGPGQEEQPPDGDKDEEQHKEEEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFM1</accession>
    <name>A0A194RFM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFM1"/>
    <dbReference type="FunCoup" id="A0A194RFM1">
        <property type="interactions" value="1369"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFM1"/>
    <dbReference type="InParanoid" id="A0A194RFM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="21549" checksum="74E312B98C8B020D" modified="2016-10-05" version="1">MEILLPTPFHGSAKGRMKYNKQVTSSRRKNRKRHFSAPSHIRRVLMSSPLSKELRQKFNVKSMPIRKDDEVQTAGVAALARQARGFLVCVQASASPPCALVVRGHYKGQQVGKVVQVYRKKFVVYIERIQREKANGASAYVGIHPSKCVIVKLKMNKDRKAILDRRAKGRLAALGKDKGKYTEETATAMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGD4</accession>
    <name>A0A194RGD4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGD4"/>
    <dbReference type="InParanoid" id="A0A194RGD4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="14887" checksum="78AA39ACBCD909A0" modified="2016-10-05" version="1">MKCGAPWMEAVGRTGAIATLTPIATSTRRPFGLTASHRLGPLANVTRHAPSLRRLGHRHCANCIDPATRDKHSRRNTTSATLAPPPPLHPRAAITPGHPPSCTTPVSLAPAPPHPPSPTPLIYLSILHLIVKALLLGSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGE8</accession>
    <name>A0A194RGE8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGE8"/>
    <dbReference type="FunCoup" id="A0A194RGE8">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGE8"/>
    <dbReference type="KEGG" id="pmac:106708702"/>
    <dbReference type="InParanoid" id="A0A194RGE8"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="37071" checksum="E94CC1BAE9E2E9A0" modified="2016-10-05" version="1">MTSEPLAKRTKMSALDQLKQFSTVVADTGDFEAMKAYKPTDATTNPSLILSAAGMEQYQHLLDKAIKYGKECGGTIEEQLTEILDMLSVLFGCEILKIIPGRVSVEVDARLSFDKDASMSKAIKLIGMFAEQGIKKERILIKLASTWEGIQAAKELEKKHGIHCNLTLLFSMYQAIACAEANVTLISPFVGRILDWYVEHTKNTYEAKDDPGVLSVTRVYNYYKKFGYNTQVMGASFRNTGEIRELAGCDLLTISPKLLQELANSEQPLKRVLDPKVAAKSDIEKISLSEAQFRWHLNEDQMATDKLSDGIRKFAADTRKLESLVKTLLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGR4</accession>
    <name>A0A194RGR4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radial spoke head protein 4-like A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGR4"/>
    <dbReference type="STRING" id="76193.A0A194RGR4"/>
    <dbReference type="InParanoid" id="A0A194RGR4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD 6 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="162" mass="17485" checksum="81AAFE21C8DC6743" modified="2016-10-05" version="1">MNGSDSSTADVKDEGEEEEDENLPLVEPETGPALFSAVAGDVPVAGAPAWSAHVSTTLTSARALALLRSKLWPGAVAYANDGKRSECMYMGWGLKAQLPNFSPLQLPRPQTEYIIGPEVMEMADPTFADEEAYRIAHLPPPPPQEMPGEGEGFPEEEEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHM9</accession>
    <name>A0A194RHM9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHM9"/>
    <dbReference type="FunCoup" id="A0A194RHM9">
        <property type="interactions" value="1700"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHM9"/>
    <dbReference type="KEGG" id="pmac:106710408"/>
    <dbReference type="InParanoid" id="A0A194RHM9"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="41"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="459" mass="48858" checksum="E5B2DB34DA0F0F89" modified="2016-10-05" version="1">MESGDRILVAAGLTAAVVVGAFVLWGPGGAPRVRKRRGQIAGLQNLGRTCFLNTLLQALAACPIFIEWLRKYAKADAHNSMITTLYTVIEVVNGTHESARGTPVCPLGVLQSLRAAGWVIPADQQDAHELLHVLLSCIEEETTAMARKPGCLSDALGLGAGGRAWSALASPASPPAAPLSLRPASAAPPEEPDLADPEPTPEPAKLSRGVSRSLCQLGTASRRWAAAPARPAPAPPTRGTLASRLQCTVCSTKSPVRYDKFDSISLSMANASIGRTGAFSLPGLLRAFTAPEMVKGVRCNKCAPEDGGMQTKHIRTVSFGKLPCCLVLHVARVEWSGGGLSKRGEFVAFPETLNMAPFAARQQPQSELAALLGGVGAEGGAAEGAERAAYRLAAVVVHVGGPRSGHFATYRRGNGFESKRWWYTSDTLVHEVALQEVLRCSAYMLFYERVRNEPRPQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHX7</accession>
    <name>A0A194RHX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gastrula zinc finger protein XlCGF57.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHX7"/>
    <dbReference type="KEGG" id="pmac:106708294"/>
    <dbReference type="InParanoid" id="A0A194RHX7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002319">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="733" mass="85310" checksum="9FAB487E3637E3FA" modified="2016-10-05" version="1">MDFVKREDPNVIDEESYKVYIDSFQKTHQMDMSDYHTPISIEQLHQAMQSSLNASSIVHNFQLSPRQMSTLMLKSNHLNRSLNFTDLPSHLPRNLTSEMDLVHNLTNDLPQNHRHDDLLLNGNLVRNLEMRSLNDLELHANLTQTLVQNLNEQELARNMSVEMGRINDVLPQNIGRSDPNLPHDLGHEIDLSHHLNRQNIEQDVLMSQEGRRTPLIQSVQDGHILEQNLVQRLEQNLTQRLDQRLDQTLGHRIEHKMELNLHEANQRHTEQGEHLIPMPFHIKSEQEDDGYFYESLSHGINDNAINGHISLHQDHTSANAAPISQDQLHYYNNHLPISALNSIDHLYSRPQNYLQNYGTSNISRDNPQNLVVHRQFNNSPYPEEFKKPIEDGDVGGKIDSSKNEEPKENLKPTDQNKMFYTEYNQNTYTNNTDKNDNETSTNNKLFDEVSLNIKGEYACFKCNEVFPCKRGLRQHVKTCVEIGEMNDLVEKLGKFCCTQCSYRCQSPAILKIHERTHTGEKPYSCTFCDYKSGQKNNVAKHILVHMKEKPFRCQYCDYRCAQKNNLVVHERTHTGYKPFACPYCDYRTVQKPNLVKHMYLHTDQKPFSCDMCSYRCVQKTNLTKHKQRHMNDKEGDKVEIKGQVKPYRPRQKSVKCPHCAYRCVQKSSLEKHLQFKHNELSIEFVPEYKQGVNLKCDNICDDTIQNLSVKKDDPVYVENVCQDKAMEPLKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIL1</accession>
    <name>A0A194RIL1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dorsal-ventral patterning protein tolloid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIL1"/>
    <dbReference type="FunCoup" id="A0A194RIL1">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIL1"/>
    <dbReference type="InParanoid" id="A0A194RIL1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000055">
        <property type="entry name" value="Dorsal-ventral patterning protein tolloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF1">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="175"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="325"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="645"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="936" mass="104980" checksum="F99AA285C7C985E4" modified="2016-10-05" version="1">MSEKDVYNEVPQIPVDSKRDHCNKTVEIYEDVSSPPVTADNFGRPLTCTYRFRAFRGSPKDWILRIRFKKFKVGTLINGTTCHKGYMQIVDGNSKTDVSNRKEPGLFCGEIEQPQTFISETNFVKIVFHADNFTDQTYFSFDSRAEQQFEVYLRYGQHPELYPNRRGEVVAGSYCERVFRDCRLQTCYVQSAAYPGVYPRNLHCRYHLNTRLPYIKLYIENEEFNIDGQRCENIMTCPMRPITSGSENCPYDYIRIYDGKDESASVIGTFCGMGKFPYSIIGTSQDLFVEFVSSPAGPLLNTGFHFNVGNWPGHVEAPGSRVGTCDWLLTAESLKKSGDTEGIFLSVAHWYPPHTSCTYLMQGFPGQVVRLYFPSFRINRIESPIVPWNGDCGESLTLYDAPRPDDARIIKTFCDTFSRPMEKHDFVSTGNAMFVRFESKTGSYSGSSLYYWAHYDFFNNTRFGEPVQGTACDEVIASWKQRAGRLRSPLNTLVYKQAPPGEDVHCLYRFVTDKRIFARVILTILSVNFKEHPYTAVSCQNCYEDRADKLIIWEPHPGGRVVNTSSGFSTTPLPLHLAVQRSLGSCLCAKHANTVSRARPYRVVSSGESLNLQLIVDNAHAAASYFKNPSPLFEARYEFVHGPLCGPAVLAAALDGEIVYPHLEALGYTEPPKRIQCIWDLEIEEKRDIWLHFDSIKFASRHCDDGNIQIYLPGRIEPYLSICGENVSLARELPILSAGELGFESLDDPLVIEKEKTRSIRIVFIGSASPARATFKIAWTGLYHLPKNSDGTLMTSRLTDGGSKSNSGQGCDFICPGDEALCIPARLICNGVVNCPNVTTTERKFWSAEDKRARESYSEDSLRRLGYLDAIGGIPFGQLHDEAPELCAGARSAIGGDWLAPALGAGLAIALAICALGAAWRLCCRKRSPDEESLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ41</accession>
    <name>A0A194RJ41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ41"/>
    <dbReference type="FunCoup" id="A0A194RJ41">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJ41"/>
    <dbReference type="KEGG" id="pmac:106709872"/>
    <dbReference type="InParanoid" id="A0A194RJ41"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="631" mass="70372" checksum="C156919FB2125C74" modified="2016-10-05" version="1">MSAIMNAAADVITGSAIAAASTEVAWFIPMLVAAVAYYQYDQTDPESRPADVTSDHLLPEYDFIIVGAGSAGAVVANRLSEIGHWKVLLLEAGGDETEISDVPLLAGYLQLSKLDWQYKTEPQGTSCLAMEGGRCNWPRGKVLGGSSVLNYMLYLRGNRKDYDNWEAMGNKGWSYKDVLYYFKKSEDNQNPYLTQTPYHSTGGYLTVAEAPYHTPLVSSFIEGGLEMGYLNRDINGENQTGFMVAQGTVRRGSRCSTAKAFLRPAKDRNNLHIAMHSFATKVLIDPRTKIAFGVEFVRNKMVQRVRARKEVILSAGTINSAQLLMLSGIGPAEELTKHRIPIVQNLRVGRNLQDHIGAGGLTFMVNKKISIVEHRLHTVSTLMEYAVLGKGPLTIMGGVEGLAFVNTKYANASDDFPDIEFHFISGSTNSDGGEQLRKVHGLTDEFYDAVFRPINNMDVWSIIPMLLRPKSKGFIQLRSSSPYDYPYIYPNYLTEEEDVKTLIEGVKIAVALSRTKAFQRHGSVLNKHVFPACTKMQRYTDEYWECMIRQYTCTIYHPVGTAKMGPFWDPEAVVDSELRVYGVKGLRVIDGSVMPSLVSGNTNAPIIMIGEKGSDMIKQFWLRRRISRYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK57</accession>
    <name>A0A194RK57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative OPA3-like protein CG13603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK57"/>
    <dbReference type="FunCoup" id="A0A194RK57">
        <property type="interactions" value="875"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RK57"/>
    <dbReference type="KEGG" id="pmac:106721561"/>
    <dbReference type="InParanoid" id="A0A194RK57"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="29922" checksum="9CA856C71F332E3E" modified="2016-10-05" version="1">MVVGAFPIAKLSVLLIKQISKPIANMCKERAKNSPFFRTYVCMPPAQFYNWCEVKAKMWILNLGKPVNIPVLSQEMAIELGANLLGESVIFVIGAALLIVEYNRQSKKEAAKEEKREQEMKHILGTITDLFFTVQQQQTQLRELERMVQSIDVKKPSSPQQPPSPTSPPKGPTTQDPQTVSSTPQLQNINYDRYYVTRTPYPDKGIILQSLNYIQMDVFSSLFNSPDTEKNQPMPETPTNHKREPAVLSQALYNIENNFRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKG8</accession>
    <name>A0A194RKG8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKG8"/>
    <dbReference type="FunCoup" id="A0A194RKG8">
        <property type="interactions" value="2006"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKG8"/>
    <dbReference type="KEGG" id="pmac:106707690"/>
    <dbReference type="InParanoid" id="A0A194RKG8"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000210">
        <property type="entry name" value="Alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="211"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="421" mass="48127" checksum="3A4F27FB6E7449DD" modified="2016-10-05" version="1">MVKIIFLHPDLGIGGAERLVLDAALAFKSKGHEVAFYTNHHDPTHCFAETRNGTFPVTVVGDWIPRSIFGRFKAACAYVRMVYAAVYLAWYVIPVEEPTLIFCDLISLCIPFLKMARGPFRIVFYCHHPDKLLTSEGGFLKKLYRAPLNWLEELTTARADKVLVNSKYTARVYQDAFQNIKDMPDICYPSINTDYFNTTVPKPLKEVVPVGLDKFIFLSINRYERKKNLQLALKALEYLKHVLSESDWHRVHLIMAGGFDPINLENMEHYIELTDLVAELDIEDKVTFMKSPSDAEKVSLLYHCKALIYTPSNEHFGIVPLEAMYYKKPVIAVNSGGPTETIVNDVTGFLCEPTSESFGRAMCKLIWAPDLVEKLGEAGRKRFETKFSFDAFTDQLDGILTRERQIISEVRAIEYEQRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLK5</accession>
    <name>A0A194RLK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLK5"/>
    <dbReference type="InParanoid" id="A0A194RLK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="454" mass="47472" checksum="B8D36B6CEAE66E9F" modified="2016-10-05" version="1">MVLWQMSFVEKNNDELDLPLLICNFIVPLRRLEMSVGGCGCPRQNAIVLTHVSSFRALAALAAVCLCLAGGEAQPTGCGLGHHYCPEGFYCEPDLLYCRKCLRCEDLKRESLPSQSSCIKSVSDCGPCYKGLVIDHRGDVDSPCVPRGEQGAGASAGEAEGFPVYGWVLVTLLCLLLLLLFGGIVWYVLKHPDTLKILASTSTSMQSRCERSVVPASAPEQPPPYNALYTAVQPAPPAPPAPTLVPGPVYSPAPEHATAHDNDYQPTDEECSSPFIKQSSPDREWSARESAGSQAARIYNNPAYVRRAPLPNRYENGGEGAKGPSEADLDEDTMESTWTPAQPSPAAHSNDNSSSSSGGEVVLGAGLGAGPGVSGGGAGSSGGGADLPALLAAAKGTALIRTPYARQDPNNNGNRGNGEPSFEGGSGGAQHGSSFIINVVQTISAVQQRGDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNT3</accession>
    <name>A0A194RNT3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNT3"/>
    <dbReference type="FunCoup" id="A0A194RNT3">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNT3"/>
    <dbReference type="InParanoid" id="A0A194RNT3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="11">
        <location>
            <begin position="183"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="35183" checksum="D2AFC15275FB3C0E" modified="2016-10-05" version="1">MSHNACKGYLCPLALTGGRRRPVGGMDYPVINNDKELSWFPRVRRMPEPNHRVINPSDDCFLVTSDEGEIFFKSSSDEPSVCGIYMIADPDKKIQVTFNYLDVPCENGGLVAWVDGWELNGQLWPADDWNDERLVESCDKRPQQKLTSSQNAALIQYRVPAKGKGFAITVHHLKNSKPLMVFEPNGVYTLRNHGEAGNCSVLAIAPSTVGVLSLDVGQTIKSSPLNLETGTIHFCKKRGLTDYVDIGGSSGLDYTNMEVIDSICGLDSVAGQLPAFIVCESTVVRLVSSGLYKNSVTIAFSPLVLEHIEDADMICVPSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRX2</accession>
    <name>A0A194RRX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Synaptobrevin-like YKT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRX2"/>
    <dbReference type="FunCoup" id="A0A194RRX2">
        <property type="interactions" value="2206"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRX2"/>
    <dbReference type="KEGG" id="pmac:106711045"/>
    <dbReference type="InParanoid" id="A0A194RRX2"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ20070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="198" mass="22455" checksum="EFD66FAD20456896" modified="2016-10-05" version="1">MVRVYALGVLYKGVNSATVLKAAYDLQSFSFFQRSSVQEFMVFVSKTIVERTQQATRQSVKEGEYMLQVYVRADNLAGILISDHEYPNRVAHTLITKILDEFTAKVPTNLWATGNETTIDFPVLPQYLAKYQNPREADALTKIQNDLDETKIILHDTIKAVLERGEKLDDLVAKSDSLTMHSKAFYKTARKTNSCCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSA5</accession>
    <name>A0A194RSA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSA5"/>
    <dbReference type="STRING" id="76193.A0A194RSA5"/>
    <dbReference type="KEGG" id="pmac:106720570"/>
    <dbReference type="InParanoid" id="A0A194RSA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="334" mass="36650" checksum="5533016D0386C6BE" modified="2016-10-05" version="1">MDLSIFLLQFVAFLDLLAVGLIVPLVPNHIRQLGGNHIYVGLLGSIYSGFQLGSGPLIGSLSDLKGRRTILMLTLLLCAGVYTIMGFISSIAVILILRGMLGLVYFLPATNKKTTKETKSKAEQDSVLDKIITSSKQSVVELSKIPWAEYWDVFLLKALISFAMAVYFSNYSLYLKTIYELSPKYIGYVISIQGVISSVSSFFIGYINKFYSYDIDYSVRNLHMFILVGVSLMGMILATNVYMFIVCLLPLAVGSAVGRLVSLEMVLTRCKGKHRGTLIGATNSVTSLSGVIAPMVAGFIGQYFGVAYGLYASLFATLLGVALSYQYRRKNKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSM9</accession>
    <name>A0A194RSM9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase HECW2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSM9"/>
    <dbReference type="STRING" id="76193.A0A194RSM9"/>
    <dbReference type="InParanoid" id="A0A194RSM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040524">
        <property type="entry name" value="HECW1_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18436">
        <property type="entry name" value="HECW1_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="934"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1196" mass="133386" checksum="2AAC444A4AD3294A" modified="2016-10-05" version="1">MYSYPSLLAGRRVPYRHKSYCTLDRFNESAGVAGVVGRVPATGCATGDIMWLLDEPNQPYEDCEQLLCFRYYNGESDDCVAESSALPPRFKVDLKKLPLRLKEGISRKRSGDRVSPFSYNNESFEMNSENVPQVEHVSGTNQDIKHLSDNVNKCSISTLASSENKLEQTKCDPSKCFISNIGNESQSVSSESHRAIECRPTSSGVKKKYPPPVDTAGCMTLNGVKKKSKTNSGFDSPTSPETEYYKIWSPKNPCKIMKFVYDVEGANVPNDAEKSPVPPLPPRQSHKPLERMHALSPPQVPRHRKPKKLTKPEDAFTFELIDTDEQFFTDKNINHSSVLQGGINDFRPGEFFSGKQVAMSSTTSFWREGQNVAPLATPETDGSLCESTVSSMKLSKLNEDRKTHDVPGSPSVSRNKIMFIKDIGPDNYITTTFARKDKPNVISDVVDGSNPTPNYSKSEEKAQNTFINDISNHSEFEDDNRNQIEEKEITVMKGHKPLTRQSSGRANTPTMMTAFLNSSHIDGPSREVDNNSSNAPSSCNSSHSGSPVDETSKAFPSVGTMIMNRKYSCDSSTPKHSSLPRHLLKNLGCEGTPKHSPHKTANVSKNLESPSRPHPRVLSRVAALAGSATPQCPPTPTHHARRPRPLPPPDLHPPPIQNAENFEMVEFTSELRTSEIRSPNLEFVNSNHFTIVHAGPPDDVVLRRPPADDSDDNDNALASPTPLRHMAGIRLPSIPERASRQMALTGDFPANMIGGIIECEEPLPAGWEARMDSHGRVFYIDHVNRTTTWSRPGANGSAPRSPAPEVQRRQLDRRYQSIRRTMTRTQLGDEASSPAAAGPSRAPPALPAPPAPVAPTAPVAPTAPTAPHPAAEFLARPDFYSILHMNQEASALYNGNSTLKHMISKIRRDISSFERYQHNRDLVALVNMFSEQDRDLPLGWDTKLDRNGKRFFVDHVLRRTTFMDPRVPREEASALYNGNSTLKHMISKIRRDISSFERYQHNRDLVALVNMFSEQDRDLPLGWDTKLDRNGKRFFVDHVLRRTTFMDPRVPRAARAPARPARPAATYSPLPQRRRLHEQARYLTTLALPLHYAFIPLNYAPTPPPRPPITSSDAYAHNSHQEIPVAYNDKVVAFLRQPNIMSIVRERCACSSALRDKINAVRVEGVHALARHQNDVQLTCLLRSKNRNILFLGCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RV20</accession>
    <name>A0A194RV20_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_07481</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RV20"/>
    <dbReference type="FunCoup" id="A0A194RV20">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RV20"/>
    <dbReference type="InParanoid" id="A0A194RV20"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF48">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="309" mass="35532" checksum="60122D15BC507F6A" modified="2016-10-05" version="1">MRYASKKKIFYLVFFTAVLILLLQPAIKTRRSYEIIEKQNIISSLHEETAENYTSTAIVDCDYHDIIYDDTTVPATIIDGDLNEGYRIKEGGEYAPPECKALFSTAIIVPYRDRAEQLRSFLVYMHSFLRRQHVHYRIYVVEQLDSQPFNRAKLINIGAIAAMNAGYPCLILHDVDLLPLKPANIYACTKYPRHIYILPYLNLLGGATSIMAKQFKTINGMSNKYFGVSGEVVDFFARIESLMLKICQFEPQISEYHKITNGHQGSWYTKNRKIFFTRKGMAEDGLNSLKYTEVATVLHPLFTHIMVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBF6</accession>
    <name>A0A0N0PBF6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Slowpoke-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460941">
        <property type="protein sequence ID" value="KPJ10584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBF6"/>
    <dbReference type="FunCoup" id="A0A0N0PBF6">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBF6"/>
    <dbReference type="InParanoid" id="A0A0N0PBF6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="485" mass="54210" checksum="E64086F779CB2C7C" modified="2015-12-09" version="1">MLLLVRFQLVGTQADQTHRTYRPNSTTNTLLQHLKANAEGRERESETTGHDRFYQERSRSSYRKKKKRVACRRAQSAAELNPQSIAAAQKRNAFKVRSVSTDRDESEEENSERTPLVAQKIDSLAKLLFNKSLIGGSGKSSPSESNSSPKTAEASFESSVALAICSEYLSQTSRYELKSQLGAIGSRPYKHWFIIYDKSTKTDRLLSLVPLTSKCPLEGNERCQQLTSELFRALHHPYVLPALDMRLASGHALTITPLNPRGTLKDLIYKSTWNEEYSKKYNQCGVGLPTWQVATFGRQILEGLLFLKDKGFPPFRHLHTGNVVVQNGVARISGLENTLIGALPRCPLLVVAAPELAEVLSLGHVLFEMCAGQDTNMALLDDLAPIYPHAVEAIDQIFGARTPALHELLVCELFRKIDLREMKGSCLPNFSQRLSRSCLSLLGEVARRQAGQGGRARSGLASPLTPPPRRRHFPVEQDFTEVWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCU1</accession>
    <name>A0A0N0PCU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-loop-helix protein delilah</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCU1"/>
    <dbReference type="STRING" id="76193.A0A0N0PCU1"/>
    <dbReference type="KEGG" id="pmac:106711980"/>
    <dbReference type="InParanoid" id="A0A0N0PCU1"/>
    <dbReference type="OrthoDB" id="10063280at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11431">
        <property type="entry name" value="bHLH_TS_taxi_Dei"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF147">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN DELILAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="172" mass="19706" checksum="A048D9B4342358E8" modified="2015-12-09" version="1">MPDHDKYQLRPRAARAREPRARRPPQPLSKYRRKTANARERSRMREINRAFETLRQAVPAAAITGAPVPCEKLTKITTLRLAMRYITALSSALRDSSPDSESETRLECWPSDSSTDRETETRPDRWPSPLCSDLSEFSTGQETPSEFAEDSLSPFDTFFAEFDYVDVDRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD32</accession>
    <name>A0A0N0PD32_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Viral cathepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460328">
        <property type="protein sequence ID" value="KPJ15654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD32"/>
    <dbReference type="InParanoid" id="A0A0N0PD32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="14187" checksum="3E0A48B1FFDCAFB5" modified="2015-12-09" version="1">MEYNADAFYDYYQYREDKAEKISEDTEILEDNYENEKPKYNLKDAPQLFEKFMKDYNKEYKDEYDRNRHFQNFQSNLREIIRTNEESRGFVVDINMFADLDKKEMESFYGGGEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDC6</accession>
    <name>A0A0N0PDC6_PAPMA</name>
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        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N0PDC6"/>
    <dbReference type="KEGG" id="pmac:106709520"/>
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    <dbReference type="OrthoDB" id="6378913at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
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        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR33236:SF12">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
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    </dbReference>
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        <property type="entry name" value="CUB"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857230" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
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            <end position="218"/>
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    <feature type="domain" description="CUB" evidence="4">
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            <end position="401"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="408" mass="44712" checksum="E899C9989B48368D" modified="2015-12-09" version="1">MALHKVLLLLAAAQCTFATNLYRSPRQAPGSIFTVGNGEQCLGSDRSTGGVCLSRNQCNTQGGKAIGFCGVFATCCSLNACDIRTNTKVAIFINPPLNKESSGLECSYNVEINNNNVCQMRIDFETFNLAPPTTVEAVENVTQRPGYTCRNDIFQVTNLQANSDSMPSLCGDNSGQHLYVRVNASTNSRSIRINFKIADRNTQPHLPQATWKIKVTQLECFNTLGKFRDGILEAITSSLPSTPLSSSADRDEYLIAPPGCLQYFPDRSGVIESFNYNRGDGPYIANLAYATCFKRTPDVCGVKLTAANFELAYRDELNMQVDTDCQVNPVTQGIPQSEDYLFIPEAETVEGLRGSKFCGTSAQNQIIASAPPGPVYLHFHSDNLVTDGVPESGYRFNYNVLNNCYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDJ0</accession>
    <name>A0A0N0PDJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="QFVQKCE"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 45-like"/>
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    </dbReference>
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        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
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        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
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        <property type="entry name" value="Znf_AD"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="174"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="55312" checksum="24289E7A29B6531D" modified="2015-12-09" version="1">MDLNLCRVCLDKSATISVFSKQNDIQYSAKIMRCVNINISEEDGLPSMLCSNCVAELAVCYQFVQKCEASDKTLRSLSNDYFSEIQTKIKVEVKLENVEEVNEFDHDYDLSDAASEHLQNIEKKKGKRKERKKLFKKNVRRTKAAPIQCVICGLLVISPSAMQNHMRIHTGEKPFDCSFCEAKFRTKGAMKRHVDTYHCKRERKFTCETCGNSFFRKNDIITHMRVHSGERPYVCPFCSQRFRQAASLIRHKRTHTGEKPYSCPICDKKFGDKNLVRKHQSVHSDERNFSCHLCNKCMKSKTALNAHLNLHTNEKQNICSFCGMAFAMKGNLQTHIRRVHSEKSGQCNICLKTFSNLEVHMRKHTGEKPFTCGLCNAAFGVKRSLAHHIMFKHENAEKFKCSIGECTKTFPTATMLEFHLLKQHTNHTPYICQYCSRGFFRTSDLSRHLRVSHIDSQIKPISLKPLVAKPCTLQYSVPNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDV4</accession>
    <name>A0A0N0PDV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gephyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDV4"/>
    <dbReference type="STRING" id="76193.A0A0N0PDV4"/>
    <dbReference type="InParanoid" id="A0A0N0PDV4"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007529">
        <property type="term" value="P:establishment of synaptic specificity at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072579">
        <property type="term" value="P:glycine receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="MoeA C-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="14881" checksum="6C2502F5B0150EE7" modified="2015-12-09" version="1">MKPGKPSTFATCQYEGKTKYIFALPGNPVSAYVCCLLFVIRALRVCERRSAEFPRMRVRLNKHLALDPRPEYVRAVLKFSDGLPSAEVLGNQCSSRLLSACGASVLLELPPADKDLRSLAAGTLVPAIITGRMDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE37</accession>
    <name>A0A0N0PE37_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell growth-regulating nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE37"/>
    <dbReference type="STRING" id="76193.A0A0N0PE37"/>
    <dbReference type="KEGG" id="pmac:106720487"/>
    <dbReference type="InParanoid" id="A0A0N0PE37"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Cell growth-regulating nucleolar protein-like winged helix" evidence="10">
        <location>
            <begin position="348"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="421" mass="48024" checksum="07AE3E8E24E92754" modified="2015-12-09" version="1">MVVFTCGHCGESVQKPKVEKHYLTKCRNRTPNLSCMDCFKDFLGNDYDAHIKCITEEERYSGKGFTAKEKKGEKKQNAWVEMLQSVLDETETKSPNVLRIIETISKHNNTPRKKPKFVNFVKNVCGQKTNPKDIDQAWDLISVKLAALSQVNGHNKNNSEKNTNGECNGKSEDKSKGISKDNVKNGDEVENATEKEENEDESNDVPIKNGNCDVPDKKLSKKQRKEEKKKKKYEAELQDAEQHPAEEEVVEVQSKKKGKKNKNKENKANGTDEAEGDNNIEGKNKNKKRKRQDTVNTIPEVVEDEIAIEEPIKVKAQQKKKKVDSEEDSVTLHDQNVAKSEEQSTKNDKFNWHAVIVSVLQKKDNEVPFKRLQKKVLSEYSEITGNEVDDRIAEKFIKKLKSAPNVRVDKNRVVLVQEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE44</accession>
    <name>A0A0N0PE44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE44"/>
    <dbReference type="FunCoup" id="A0A0N0PE44">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PE44"/>
    <dbReference type="KEGG" id="pmac:106707737"/>
    <dbReference type="InParanoid" id="A0A0N0PE44"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="340" mass="37205" checksum="1692B73A522C6BDB" modified="2015-12-09" version="1">MNELDSLRQEAETLKNAIRDARKAACDTSLAQATANLEPIGRIQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHSGYLSCCRFLDDNQILTSSGDMTCALWDIETGQQCGQFTGHTGDVMSLSLAPDQRAFVSGACDASAKLWDVRDCQCKQTFPGHESDINAVTFFPSGFAFGTGSDDATCRMFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMKSERAGILAGHDNRVSCLGVTENGMAVATGSWDSFLRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEC9</accession>
    <name>A0A0N0PEC9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0672 protein C3orf58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEC9"/>
    <dbReference type="STRING" id="76193.A0A0N0PEC9"/>
    <dbReference type="InParanoid" id="A0A0N0PEC9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073:SF7">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAM69 protein-kinase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="289" mass="33524" checksum="B63C7FAA47B4837D" modified="2015-12-09" version="1">MEENCKPIQLINTTNIDDKIISIVEYNFTWPDSEPRKGLVLCPYAYSIHDLIKPLIDSRKLNNKSEKLNIWTMLSINPEPIILQLLPKAHSWPVPAYAGVCGRLEVVAYEGVPISSLTHIEWRRKLKIAKKILDAAMDFTFKHDRFRFYLMDWSLDNIVANEKDEISFVDLEDVIVLDKHISPRKDLPDWYQRYNRELIGPGFTFSIENMCKHHLSDHNLWAACYIIGGEDNPLLYPIPKSINATRPHLDKLLIECLNSDDRFKTLAKIQHYISDMLTDEKLFGSASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEQ2</accession>
    <name>A0A0N0PEQ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459736">
        <property type="protein sequence ID" value="KPJ20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEQ2"/>
    <dbReference type="FunCoup" id="A0A0N0PEQ2">
        <property type="interactions" value="903"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEQ2"/>
    <dbReference type="InParanoid" id="A0A0N0PEQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="63"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="7">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="22211" checksum="A5CBADCED5D660F0" modified="2015-12-09" version="1">MTSNEIEKSNCIFCNIVNKLESTEILYEDEDVCVFRDIKPASDFHILTIPKRHIEDAKALTTADKNLVNKLESTEILYEDEDVCVFRDIKPASDFHILTIPKRHIEDAKALTTADKNLVDRMLCVAKEQLAKNNLSVDDARFGYHWPPFRSVRHLHLHTIAPESKMGLISRIIFKKDSYWFVSPDYVDSRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEW1</accession>
    <name>A0A0N0PEW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 CYP12A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_00963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459668">
        <property type="protein sequence ID" value="KPJ20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEW1"/>
    <dbReference type="STRING" id="76193.A0A0N0PEW1"/>
    <dbReference type="InParanoid" id="A0A0N0PEW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="484" mass="56028" checksum="5D54E614A03752A2" modified="2015-12-09" version="1" fragment="single">ITTVANIDVTTTPSKPFRDVPGPKSMPVIGQLYHFLPGGLLYNLRGSNLHNFLYEKYGPVVKMKGHFGAKDSILLYDPEVALQIYRSENSTPIRIGFFAAQHYKHVVKKEKGEERKYSGLIFDHEETWREIRTHVNPVMMQAKSLKPYAEPLDEIAQEAVARMKCIRNENNMIENNLLEEFMSYVLEFTGIIALGRRFHAFDANIREDSLTRQLLRNVQDFFALSDKLDFQPNLWRYYPNKTFKTAMKFLEDAEKLNEKLLRTAMEELKTNPKPEEKKGVLEKLAEKNEEVALAFADDMFFVGVDTLANGIISVLYLLANNPDKQNKLREEIMSKESRRPYLRACIKEAARMRPVAFGNLRLTTTGYNVFDYEIPKDTMVLFCHEHMSLREDQFPQPNQFIPERWLVDKDHPLYHGNAHPSAAVHFGYGARGCVGRKAADMEMEILISRIIESFRLQWRGKPMPVYQSVSNHNMAPYNFIFNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEW4</accession>
    <name>A0A0N0PEW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459647">
        <property type="protein sequence ID" value="KPJ20521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEW4"/>
    <dbReference type="InParanoid" id="A0A0N0PEW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="193" mass="22188" checksum="8F5845B31EFBEEA6" modified="2015-12-09" version="1">MAEVLQVVEDKLVAKVVVVHRLVVAVLQVVLQLKKAVRVLQVPVVVLQVVLQLKKAVRVLQVLAEELKKVRPQKKVVLAVLLLKKTVLKKVRPLKKAVPVVLQELEAVLKKVKQLKKAVPLLLKKVLVLLNHKKQNLNLSQNKLLPNKNLLLLSTYPRLFLLKKFYHLKPSLILNLLPKNVEKKKKKMFRKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I4R7</accession>
    <name>A0A0N1I4R7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box/LRR-repeat protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
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    </dbReference>
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        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CLUMA_CG018969, isoform B"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="306" mass="35076" checksum="26026BB6ADCC3E13" modified="2015-12-09" version="1">MDISTDVWGQLALEASQVYLTEGGVRSPFAGTTIEKLPDKVLLNIFSYLSHREICRMATVCKRWRMVAYDTRLWTHVSLRPEISGLHVGSLESLLALISIRFGPSLRYIELPIELITHTVLHELAAKCPNLTHMLLDFSTAMQLHDFSEMQAFPTKLRYLCICLSEVIFMEGFMRKIYNFINGLEILHLIGTYEKVEEEEEEIYEVINVHKLKSATPNLRVINLYGINFVDDSHIDAFSSNCIQLECLAVNFCNKVTGSTMKTLFQRSRRLTCLLMNGCSLQSEYVMQVEWEKSSIQEQTCLRNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5H0</accession>
    <name>A0A0N1I5H0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05835</name>
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    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461033">
        <property type="protein sequence ID" value="KPJ09972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5H0"/>
    <dbReference type="InParanoid" id="A0A0N1I5H0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7777" checksum="DB5ED07CD23FC4A3" modified="2015-12-09" version="1">MRSDDARWTKQVTLWSGPGRGKRKRGRPKARWIDDIVKIAGKAWMRTAADRDKWRNMEEAYTQQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDQ6</accession>
    <name>A0A0N1IDQ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sarcoplasmic calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="31526" checksum="FAC92179E35B73E8" modified="2015-12-09" version="1">MAASLVRLGLRSIALNLERTAALLSTTTVQNQIKLIHSKATCTGTVCYLPEREAELDRGAYRRYSKQHGRPDQHRRKHDSDSASESDSDTECKGFDRSEFWRRKMRTVHNILDVDKDGLISFSDFQLFADRFKALGHLDDEQAKEFTAIIKLTWEEQWGAIDPYNFVTVEQYLEDMHHVLSDRSLKKRAHRWLPYLFKAVDKDKSGYISVAEFKLFFQCLGLSNEHAAVAFAVIDTNGDGKLSLKEFVKLGKDFFFTEDESKVSKMFWGPLIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE56</accession>
    <name>A0A0N1IE56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-resilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460601">
        <property type="protein sequence ID" value="KPJ13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE56"/>
    <dbReference type="InParanoid" id="A0A0N1IE56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF98">
        <property type="entry name" value="CUTICULAR PROTEIN 56F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="473" mass="52301" checksum="5F754F5D0FAEDE54" modified="2015-12-09" version="1">MIVFVCLLSLALAEPPVRDSYLDAAESLQDHGPHQQYIPDLIAPSARHQTNPQHVPTSRLSQHGAPDFRDNLSQVYSAPKNSRISQEYGTPEFRDNLSQVYGTPKNSRLSQEYGAPDFRDNLSQLYGTPNQESFRSLSQEYGVPATSQYDDTNFSSIPKSSVTHYGSPTSRKLPSSSYLPSQRSTSTEYGLSDDLSRRSSTRNSSPVQKYGVPKFQSRQSQFTSDGYGSSNAVLSSARSSNYQAKAPSQFGTRSLPTLYGGPEARNGYPEPLEKFGVPNTRISQEFGQLAGRSIGAKTNALTSSYSTIKSPSQQYGVPQSRDSMPSIQYSAPVDGVSDQGYNYTRNALDLLNQEPANYEFAYKVDDYESGSDFGHIEMRQEDKAEGSYFVVLPDGTKQEPANYEFAYKVDDYESGSDFGHIETRQEGKAEGSYFVVLPDGTKQVVEYEADEEGFKPRISVQPADVDSRNAGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGV8</accession>
    <name>A0A0N1IGV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGV8"/>
    <dbReference type="STRING" id="76193.A0A0N1IGV8"/>
    <dbReference type="InParanoid" id="A0A0N1IGV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="204"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="519" mass="58446" checksum="46CB07E64141272E" modified="2015-12-09" version="1">MTNTEIPAKRLSTSDNKASKQEKIIDGTAPDAINDDHDSGGPAVRDGILLGIVSFGGRKCGDPQSPGVYSRVSEITSWVESTITANEASTVPELVPKILKARQREKELQNLIILLLNKEIDGDIFNDKPILRNKEVGHGNVDKKEVDSREEIKALLEARYKFSNDETSTRYRITRDDRDSAGISESHDEKQLALVFRSYAARRIVGGMETSISMYPYNVAISRNGNHWCGGSVIDEQWIFTAGHCLESAHDGDQKKLINYIVRAGSSFHNRGGYQARINKAFFPSNYVPGNADFDFSLARLDRPMPIGRNIAVLNLPSRDYQIKTDDILIVTGWGSTDQSGYGNIPDRLRFVPVPVMAADECQHAYRFYITPRMVCAGYATGGKDACNSALIAEFKAQVEDKKNKIKNWLRETLSSPTFLELAKRKLKEAGFNLRRRYRRNYDDDINDDSFLDDSLMDDINLTNQINERILGDGEENEAEALLRMMALQEIMDENKDNDFGYRNSSRKTRARDLIAYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHZ1</accession>
    <name>A0A0N1IHZ1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHZ1"/>
    <dbReference type="InParanoid" id="A0A0N1IHZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22451" checksum="40AF4C8224F31356" modified="2015-12-09" version="1">MLDARIDFNRKYYDHTKERPQPGRVGPFTGGPFGGPPLGHHPQDIYRPAGPYSAPDRGQIESFPYQNPTTPLAPGYTDNRQNMATQYPQQDTVSPQGYQQGYQTYPPQVQREFQPPGYPPPGYPQGYPQQGYPQQGYPYQQYPPPQAPSMAQTTFCAACMACLTCLMCSCCQGLMGVPGDDSIAENDSNPTGAQPQVSPPGPIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IID7</accession>
    <name>A0A0N1IID7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IID7"/>
    <dbReference type="InParanoid" id="A0A0N1IID7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="278" mass="31917" checksum="90426EBDC152197C" modified="2015-12-09" version="1" fragment="single">LGRSTVGNIIYQTLNVIWRALRRIHMPSVNQSIFKKKSDDFLMKWQFPNCMGAIGVKNFPIVKSPNIGGERMNNKYCSLVLQAISDADYKFTVIEVVGRECKRDGNIFHFSTSQFKKVLERQQYIIPPGQKLPGSDLTLPHVLVGNAGYPLKTYLMRPYPSLKLDNERKIFNDRLFRARDTIDVAFGVLTNKWHIFNKSLETNTKHAVLIIKATCLLHNIVVDKDGNNDKDYKDCNTLSSNAKDEKVNKSKRNSRSSFHAIAIRDKYKNYFVNNPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJM9</accession>
    <name>A0A0N1IJM9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459891">
        <property type="protein sequence ID" value="KPJ19548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJM9"/>
    <dbReference type="InParanoid" id="A0A0N1IJM9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="60848" checksum="615010DB3B8E59ED" modified="2015-12-09" version="1">MCYSRLPVPKYTDIMALCEGQLDSVLPQLKREESSPSSEGPESPQKKPKLEPNGDIYGLNKVAGGLPLSVDYRSPVSHFVPPAVELYAARHKTRDISNGPKAETSSSTPAKRKRGRPRIDKTSPEYLANVAARKQAKEMEALEKKAKREYRRRTGGKPMLKISSGSRVVKTIQARSKHMRKLPPHAGVRQIDDNKVLVRQNDQKVVVRRKTMFIKRKDSAASSSTGDSTPRVKRKYTKRTPSTKKNDSQSSGERVKGKRGRPRKIDQLAKEQQPKIRVRSNLMPNSEPIPVDSDDEPGLAAVINNRSDTGEKRKRGRPRVDKTSPEYLARKRIRELEALEKKAKREYRRRTGGKPMLKISCGSRVVKTIQAKSKHMRKLPPHAGVRQIDDNKVLVRQNDQKVVVRRKTMFIMRKDSAASSSTGDSTPRVKRKYTKRTPSTKKNDSVSRCDMCGAQFPRYEQLSRHRQCAHGALPPHMPHACAQCGKRFSHAHSLTRHMHNHAKQLYRCVVCKASFARADQLAQHLNSHLANYKRMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJY7</accession>
    <name>A0A0N1IJY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfotransferase family cytosolic 1B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01060126">
        <property type="protein sequence ID" value="KPJ21605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJY7"/>
    <dbReference type="FunCoup" id="A0A0N1IJY7">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IJY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="45635" checksum="4FBF68542D6EA930" modified="2015-12-09" version="1">MQQPKSFPFDIRDVEEHENEELCKYFSGVNGKCNIQVGPKKYLLLSDYKNEAESIYNMPLRTDDIFIVTFPRSGTTWTQAIVWLLAYDLDFSTANKIPLEERSVFLEFSMLMHKGILEKLKKVHAGTTWTQAIVWLLAYDLDFSTANKIPLEERSVFLEFPLLMHKGFLDKLKKVHAGKEEKLKALDLLSVPGTVQVAAMPSPRVIKTHLPMSLLPPSLPDSCKVVYVARDPRDVAVSCYHLNSEFQSVKFNGDFKTFWSLFVKDLVYWSPFFDHLKEAWEMRHHPNMMFLFYEELSQNLSATVKRIADFLGKEYTAEQLDDLCTHIKFDNFKKNTSVNIVNMKELGIMAPKGEFIRKGKSGGWRDYFDADMSREAEDWIAKNLQHTDLRFPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INP2</accession>
    <name>A0A0N1INP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cuticle protein 18.6, isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INP2"/>
    <dbReference type="FunCoup" id="A0A0N1INP2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INP2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005615">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874063" evidence="5">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="184" mass="20581" checksum="C9CFD83A4687B308" modified="2015-12-09" version="1">MVAKLVFLFGFIASSTCMVLHQAPIPLYVPIHYEEPAPNYNFGYQVNDPHTGDYKRQHETRIGGTVIGQYSLIQPDGVTRTVEYRADDVNGFNAVVNNEGTPYIAAPERQENVNVRQENGNGRQEDGNGKQEDDSNRQSNPRPQVEQSWQGQGPNEQQSSPTPLTISHTSLIHESYSKGHKSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB6</accession>
    <name>A0A0N1IPB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPB6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPB6"/>
    <dbReference type="InParanoid" id="A0A0N1IPB6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="507" mass="57021" checksum="20C69FB71B3605C0" modified="2015-12-09" version="1">MDKYKTSNVSFLQFKINNKKLYITVNKINLSNVFQLFIFSGLTICSVSDGFIFGQMSGMVDALRGKENGLSLNDGDISWIASTINATCIFGFVLAGMVTEKVGRRRAIAILSLPMILTWIMLYFAESFAILVASRVIVGISYGGVILLTYVTTAEYTTTKQRAAFVTIVTAVGPSIGTALGHVLSILMHWRTVALIGIIPTTLSIVLPLFWVESPSWLASKGRFEESMAAYRELHGRSEATEVELKLLVNFEKTKQKEFTPNKKLYLSMLEKIILALKQMYFWKISLLVAVISVYRVAGGRILYNTLAITMLQEMTKNSNILMSTLLVDGFIVTGSILPVYLFRKMKTRTLLFLFGLTSNIALIVLSACLYYIPRENVYFAWVCSSLLAFYFIIAYAGPYAVLELLLSELYPLELKSFCTFFYGTFAGFATFLSIKLAPTMFDSMGYHGVFLLNATIVFLCLGYLWFYLPETKGRTLQEIEQYFRNGNFDNDTDLNLEQCESEDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPE2</accession>
    <name>A0A0N1IPE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ13985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPE2"/>
    <dbReference type="InParanoid" id="A0A0N1IPE2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12276" checksum="51C8CEF089EA17EC" modified="2015-12-09" version="1">MDSNKFPSTGIEFFEITNPPTRRKKIINATAPTVPLLLDLYVQAYSRLVMQRTFVSASAEVLFSIHVYALFTIKKVINKLQMGYEFKFVKQVSASSNSLLPSKKEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPY3</accession>
    <name>A0A0N1IPY3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ferritin</fullName>
            <ecNumber evidence="16">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_01866</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of a heavy (H) chain which is responsible for the oxidation and uptake of ferrous iron, and a light (L) chain which facilitates the nucleation of the ferrihydrite iron core.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="16"/>
    <dbReference type="EMBL" id="KQ460130">
        <property type="protein sequence ID" value="KPJ17532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPY3"/>
    <dbReference type="FunCoup" id="A0A0N1IPY3">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPY3"/>
    <dbReference type="KEGG" id="pmac:106708136"/>
    <dbReference type="InParanoid" id="A0A0N1IPY3"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin"/>
    </dbReference>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF43">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874105" description="Ferritin" evidence="17">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="18">
        <location>
            <begin position="35"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ17532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="23731" checksum="E9B249142902D437" modified="2015-12-09" version="1">MKAVIFAVAALLAVCIPISAKQCNVNPVNIPKGWITMQQSCRGSMRRQIQTEVGASLQYLAMGAHFSRDGINRPGFAKLFFDAASEEREHAMKLIDYLLMRGELETDVTSLIQIRAPERKSWESGVDALEHALKMETEVTKSIRSVIIACESDPKFNDYHLVDYLTGEFLEEQYKGQRDLAGKASTLKKMLDRHSSLGEFLFDKKLLGMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ68</accession>
    <name>A0A0N1IQ68_PAPMA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1IQ68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="754" mass="85446" checksum="95F37AEC89C2862A" modified="2015-12-09" version="1">MQNGEETAAPVENSAFSLIVAFIALRCVCADYFAINSPNGLAMFPRPVFNRIPNFKGAPEAAARLAELDVFKNANTVKVNPDKPQEPVRCQSKGRIPNLETYVLPTDLISRVMCLEQKKTLYVPVPRLQTGFLNRIVLPEGEPGNAAYRKAVSRNGMEVYGQPIGIEDTVIHRVMCLEQQKTLYVPVPRLQTGFLNRIVLPEGEPGNAAYRKAVSRNGMEVYGQPIGIEDTVTLDLVVMGSVAVSKEGYRIGKGRVLKVKENIVMLHISEKKFNMCEVFDTLPAELFGPHDVPIDLIVTPTQVIETQRMSQRPTGILWHLLSNRRLELMPILGQLREIEMLAGRSCTLKEVDTDVEERSQGRPRRPRRRTRSSKSHSEGEGGNTTEGEEAKTGKARRAARRRHSTKSKDGKEGKDNEKPRRPRRPRPDIEFSVKISNISPTTRVRDLKQALSERGVKPQIMVWKGFRGFCYLHFFKPVPQKDIIEEYVLNFDSGLYVCGDEQSKAYFDCSRVEVSRYNETTTAMFGVARLLKGMDENTLVEAYVEKDVSGRYELVMSHEICNICDELGKEESNYYSYIKDIELPDSCPFPPAEYTITNLVIDTKYLPMNKANEGRYQMTLNFYDSPNRDCTGPKTFNACLKVDMVEAYVEKDVSGRYELVMSHEICNICNELGKEESNYYSYIKDIELPDSCPFPPAEYTITDLVIDTKYLPMNKANEGRYQMTLNFYDSPSRDCTGPKTFNACLKVDMVIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQC4</accession>
    <name>A0A0N1IQC4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQC4"/>
    <dbReference type="STRING" id="76193.A0A0N1IQC4"/>
    <dbReference type="InParanoid" id="A0A0N1IQC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="69" mass="8068" checksum="70B4B8CA8C982E68" modified="2015-12-09" version="1">MAETESTDEIYNKEYRRIRRITKDLAIRQISSEYGLTEEQVAEFKEAFMLFDKAKDGTITMAELGVVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFT0</accession>
    <name>A0A0N1PFT0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil-helix-coiled-coil-helix domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CHCHD7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461110">
        <property type="protein sequence ID" value="KPJ08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFT0"/>
    <dbReference type="FunCoup" id="A0A0N1PFT0">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFT0"/>
    <dbReference type="KEGG" id="pmac:106717343"/>
    <dbReference type="InParanoid" id="A0A0N1PFT0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="10059" checksum="E9C2B60D7B3FFCCA" modified="2015-12-09" version="1">MKLNNADAAARLNPCLKEQNQSYECLNKNGYNQEKCEAYFDNYNTCKKFWNQVSKDRRAKGIKPHLPDVEEREKVKEEYIKAWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGE6</accession>
    <name>A0A0N1PGE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynein heavy chain 1, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGE6"/>
    <dbReference type="STRING" id="76193.A0A0N1PGE6"/>
    <dbReference type="InParanoid" id="A0A0N1PGE6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF28">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="388"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="818" mass="93794" checksum="D1F2087AABEF4052" modified="2015-12-09" version="1">MKIADETLQLLDEHLLNTQQLGFSPFKAAFELRIQEWDDKLRLTQRVVDEWIECQKQWMYLEPIFNSEDISRQLPFEAKKYGTMERIWRRIMGTAAACPKIMVTCPDSRLLDSLVEAIHLLEIVARGLSEYMEVKRIRFPRLFFLSDDELLEILSQSRNPRAVQPHLRKCFENIAKVTFEPDLKITEMHSSEGEIVELKYKFYPTANVEQWLLLLEDTMRHTIRLTLVAGLEELYQLPRNQWVLRWPGQVVIAGSQLAWTAGVEEAITEYRMDEFFEQMLQQLDSLRALVKGELTFFQREVLCALIVIEVHARDVTNTLVDENVRNVNDFQWTCQLRYYQMVREMIPLEEGESTEIYQDEDHLDTSAYYRQFSQNTCDVRALNSVFTYQNEYLGNSGRLVITPLTDRCYLTLMCAMHLRFGGAPAGPAGTGKTETTKDLAKALAVQCVVFNCSDQLDFMAMGKFFKGLAASGAWACFDEFNRIDIEVLSVVAQQVVTIQKAQIARQERFIFEGCELPLKMSCSVFITMNPGYAGRTELPDNLKALFRPIAMMVPDYALIAEISLFSYGFYEAKILAGKITTTFRLSSEQLSSQDHYDFGMRAVKTVILVAGNLIRQMPDGDERQIVLRALRDVNVPKFLADDLLLFNGIISDLFPRVEIPVVDYGIMEQSIRNILVKRGYDELYTFIFKIIQLYETTVVRHGLMLVGPAGSGKTKCYEVLRDALTAIKGKLAPDGFPFTPVHTYVVNPKSITMGQLYGEFDLQTHEWTDGILSSLVRAGIAVEDMDKRWYIFDGPVDAVWIENMNTVVENSLYQSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHS6</accession>
    <name>A0A0N1PHS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein msta, isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHS6"/>
    <dbReference type="FunCoup" id="A0A0N1PHS6">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHS6"/>
    <dbReference type="InParanoid" id="A0A0N1PHS6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="609" mass="68157" checksum="79D73DDDB8984B6B" modified="2015-12-09" version="1">MVLTDCREYMRPTYVAHIFYIVPLARGVKWRTEIHPDYAYRLQALIHKAVIRHAADTLWPTLVHSQITRIRSSLDERAAHVGQKKRGKGEGRNKENVEDVQTSEAAQEPQPSPKPQDDQLCYEVKHSDVMGRYVVARRDIAAGEVIMEEPALVVGPCSGCGLICLGCYRELEDNAIVKCKGCSWPLCSESCPGQGKYTGHSAAECATLSAAAVKPDYNNLEDLKDCYHAITPLRCLLLKKEDPAKWTLLCAMEPHNALRRARADIWPANQNHVVRRLQDWGLQYDEEEIHTVCGILEVNAFEVGGSGASARALYDKAYLLAHDCTPSTTHTDAERRAGRPLTVRAALPHRPGDLVSLCYAYTLQGTLKRREHLKLSKFFECACKRCADPTELGTYCSAFRCPKCAGRVLSAAPLDPHSAWQCSAPGCSYAMPAVAVQMLLKRLTDEFEQIDANDVCGFEGFIKKYSSALPTSHYLCLSALHSLSQLYGKVTDYMIHQMSDAQLHRKVQVCRDLMKVFDHIEPGYSRLRGITLYELHAPLMVLTTRDFEKKAITKDNLRERLKEIVSYLTESALILGFEPSQTSEGLMASAARDALKKIKTWEQIIGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIE7</accession>
    <name>A0A0N1PIE7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="20">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_03351</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="EMBL" id="KQ459761">
        <property type="protein sequence ID" value="KPJ20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIE7"/>
    <dbReference type="FunCoup" id="A0A0N1PIE7">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PIE7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23462">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000047">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="536"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KPJ20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="671" mass="76171" checksum="40D7BE72087E1A00" modified="2015-12-09" version="1">MFFLRRRTLILKAVLILTALWFMVALLTTNGGSRNSIVAPPIEYEDAEAKPLKMAKPTSGKKKSESYGNNLSDGLGVIAAPGSDNAPGELGQPVVLPKNMSEEAKLAVSEGWKKNAFNQYVSDLISIRRKLPDPRDEWCKKPGRYLEDLPQTSVVICFHNEAWSVLLRTVHSVIDRSPPHLIKEIVLVDDFSDMPHLMQQLDDYMSSLPKVRIVRATRREGLIRARLLGARYVTAPVLTYLDSHCECTEGWLEPLLDRIARNKTTVVCPVIDVIDDNTLEYHYRDSSSVNVGGFDWNLQFNWHPVPARERARHQHTAEPVYSPTMAGGLFAIDKEFFERLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRTGVNVLKKNSVRLAEVWLDDYAKYYYQRVGNDKGDYGDITSRKQLRDNLGCKSFEWYLKNIYPELFIPGESVAHGEIRNVAFQKTCLDSPTRKSDHHKPVGLYPCHRQGGNQIRNRAFDSDFCLDGETLEETEGATGPLMIHKCHHNGGNQIANPSTEMCIDSGAGPEEMKKPVNIWPCHGEYGNQYWMYSKNGEIRRDETCLDYSGHDVVLYPCHGAKGNQLWLYDPSTKLLKHGSSEKCMTISRNKDKIVMEPCSDAEPRQMWVMENFNADRLSPELTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIP1</accession>
    <name>A0A0N1PIP1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate [NMDA] receptor-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01024018">
        <property type="protein sequence ID" value="KPJ21120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIP1"/>
    <dbReference type="InParanoid" id="A0A0N1PIP1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="9703" checksum="474593D6220369E9" modified="2015-12-09" version="1">MLIFTSARRKVPYNYIFLMLFTLSLTVILPLILEQIPADQILFAVGLTFAVVFTLTLFAFQTKIDFTFLTSYCLCLVLPLMLLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIS8</accession>
    <name>A0A0N1PIS8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040409">
        <property type="protein sequence ID" value="KPJ21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIS8"/>
    <dbReference type="InParanoid" id="A0A0N1PIS8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="14031" checksum="E4FCB98E308206DD" modified="2015-12-09" version="1">MLMYVPWLKPSLRYSHVSLVPSVLPSPTKAQTSRTKVPTPRLKRVETSRRNQKMKKPTEEVNTKIESSRRETANESPKEVVKSGRVVSPVVPFEPDTSRNEKKYKVSTSLSLFSNLLMYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIV6</accession>
    <name>A0A0N1PIV6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460596">
        <property type="protein sequence ID" value="KPJ13910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIV6"/>
    <dbReference type="FunCoup" id="A0A0N1PIV6">
        <property type="interactions" value="1438"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIV6"/>
    <dbReference type="KEGG" id="pmac:106712089"/>
    <dbReference type="InParanoid" id="A0A0N1PIV6"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="360" mass="41271" checksum="4CDAF8E2DA2ABC98" modified="2015-12-09" version="1">MAKDTLNELHQFLKPESRIDLKLISLDHLIGVSGTEGGVKILVGKENILKSVIDCTNDKVDNVTKKALLLLINITAYSEGSIELLKLKPNDNKSVIDIFVGYVLDAQKTHADAVCMILSNITRVEENVEQCVDILYKHLNNLLNVFVNTEFNKKGCNLEYLAPMFSNLSRSERVRTWLTNENPHIPLLKLLPFCQYEKSIIRRGGAIGTIRNLTFDVQYHKLLLSPDLDLLTYLLGPLMGGEDYSDDEMDKLPIALQYLPKEKQRETDIDIRKMILETLNKLCSKREYREILRDNGVYYVLRELHKWEKEPSVRLACENVVDILIQKEEEVGAEDLSKVDIPEDMVDKFEKMDAEYLNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKE0</accession>
    <name>A0A0N1PKE0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459764">
        <property type="protein sequence ID" value="KPJ20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKE0"/>
    <dbReference type="STRING" id="76193.A0A0N1PKE0"/>
    <dbReference type="InParanoid" id="A0A0N1PKE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="500" mass="57054" checksum="D990CC85D8FCCC73" modified="2015-12-09" version="1">MTCPDICPTSGTDRLPESKSENSNQDGVPTSVCSPYRPGCIQPPEPKVYPPNAPPRYLPQPTDTTSGDFLGMGSIDPWAAGHLDWTPQSGITGVRPVVDKYSMTRYSTRDWRLNNESVLTPRSVDKAKLFETNTKKQLAETFEEMDKKLNNSNNELDKRIKECEDWKAKVEKTLEAITDEINILDENRARLKGACRILMLPEAISRECLELRTQRYEPDLVRDDAEQELMREVAIVGEIRRVFMNTLAKVEEQMAMNKAAKATIETDWNDKVVCLKLDKENFNWTVDSNLILYHPAVVRWPENACTLEYWKHYCAESIRNCEEVRKKSEDLRGDLMTAIIKGSQDMKLQADRTNAAFGETIAATEGMCEHLEENLKNNLQTIADLESLIANLVATLSNMNDRNKLVTSRLQARNYDRCNVENCRDNAQYALMAEAKYVKEASQKFSNKLREAESVRADLMIYRGILEKEIACKRKSLYIDKDRCSRIRAHMPTPEEFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKG4</accession>
    <name>A0A0N1PKG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01065826">
        <property type="protein sequence ID" value="KPJ21670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKG4"/>
    <dbReference type="KEGG" id="pmac:106707600"/>
    <dbReference type="InParanoid" id="A0A0N1PKG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="10842" checksum="D452EC78767933FB" modified="2015-12-09" version="1">MAENKDQSAQGGYPQGGYPQGGYPPPGGYPQGGYPPPGGYPPGGYPPQTGYPAQPGFQPGYGGAGFGEVSISLTSRSRAVASKVVQVLWETRLGDTIEGYKVEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKM3</accession>
    <name>A0A194QKM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-directed DNA polymerase from transposon BS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKM3"/>
    <dbReference type="STRING" id="76193.A0A194QKM3"/>
    <dbReference type="InParanoid" id="A0A194QKM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="622" mass="71775" checksum="78195176306FA7AB" modified="2016-10-05" version="1">MYYKNLKTLVINSIHNEKRAYFDHNINNNLHKPKILWHNLKSTILPPNKYTLPAHLADPDNINCHFLNIPGIPRADPSTLSYFDTHLHPNNTFFSLHPVSELFISKIINNLKSNAEGIDGITLKMLLMTLPQSLSAITSIVNCSITSSTFPKIWKTAIIRPLPKNPNPQELKDLRPISVLPFLSKIVEKVVWIQLTDYLENNNILPEFQSGFRKSHSTTTALLDVTDNIISAQDEGLCTLLVLLDFSRAFDCIDISLLLSKMSYYGFKSDTVQWFQSFLTNRGQCVEITRDSGQTQRSAYRSLERGTPQGTILSPLLFILYTADIIKCIENCKYHLYADDLQIYVSFRSGEWASAVRSLNEDLDRIQRWSENNCLVLNPSKTKYMIFGSQYQINNIPPDCQVTLGSEVVERVYEAKNLGLLLEPSLRYEKHISGVVRSCFYRLKVLYKVRRYLSERLRIQLVEALVLSKLNYSDAVYGPRLYARTEKLIQRVQNACARFCFSIPPRNHVTPFLNEHNMLKITYRRKLHLACLLFEIINTEAPKYLSNKLIFTRSRGSEQGRRFPQLCTQRHKSAVFRGSFRYAATKCWNNIPPPIKSARTKITFKSTLHLEMYKSSCRPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLA4</accession>
    <name>A0A194QLA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ficolin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLA4"/>
    <dbReference type="FunCoup" id="A0A194QLA4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLA4"/>
    <dbReference type="InParanoid" id="A0A194QLA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264458" evidence="4">
        <location>
            <begin position="18"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="254"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="573" mass="65522" checksum="34AC3F0B4AA22D1D" modified="2016-10-05" version="1">MLYILLLALLTMSPISSEVAPDPSRAKKQKHRSDHSDKNAWKKEYEDELSRAMLASRKRDNYTRVVQSAMMSENEAVIEKIMESITTSEKYLKKIDSIDFRLNRLDIEVHEKTNNILKYLAALSKSLQNQLFPEKLDTAIDLLKTDISYLRAKLEKTSQGGITLPYMDTGVYRLESGLDARLKFVEDHIKGIMASVESISGVISEVKHRQNSKLYHNRQESGGGLDSLSIISEFRKALHEQKPKKCECKIGRMDRNERYPTDCHEIQIQGFNVSGIYKIKPDDIDPFYVLCDLSTAGGGWTVFQNRYDGSQDFYKSWSEYKYGFGNLAGEFWLGLEQLHHLTSQKLYELRIELETQHGRDGFAGYSVFTIAPEHEGYRISTLGSFHGSAGDSLSYHAGQKFSTYDADNDEWKEGSCATEHGGAWWYKECDKSNLNGRYTLSAEEPQGQNMYWISFKAPAVPLTKSRMMIRPLPASRPLDYSQYPRKILESTKVKPSEEQQKGLRAKPTFEGAHIRKPYRYEGHTREERSDSVSTAIHVHAHQGATQAQCCALRYTNIQAEDTKWLAIECPHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMK9</accession>
    <name>A0A194QMK9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tyrosine-protein phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMK9"/>
    <dbReference type="InParanoid" id="A0A194QMK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11098" checksum="C8F58F0A7CC9724D" modified="2016-10-05" version="1">MAGRIPDRWLQYKACGKVIEGTRIICFKVPLKRECPGEQLVLNKMAQRFSKYDVSVVENILFKDESMKALVRRSAALQEICPARVDPDGGGVVRPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMN1</accession>
    <name>A0A194QMN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic cation transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMN1"/>
    <dbReference type="STRING" id="76193.A0A194QMN1"/>
    <dbReference type="KEGG" id="pmac:106719684"/>
    <dbReference type="InParanoid" id="A0A194QMN1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="480" mass="53847" checksum="90E752769A4FF078" modified="2016-10-05" version="1">MTTEDAIENIIGRFGLYQTWVLFLIAIGRVPADFQLTNVVYILPKVNYVCLDEGASNMTNYCPCKNPEYDTGTIVESIVTTWHLICGSSYLASLAQSVLQIGILTGSLLYGYLSDRYGRKTTILMALTTDVVFVVASALVPDFWMFLVLRFLIGTSVGGTLICSYTLMVELSGKSFRPYLPGLTQIAYATVSIVHPIIAYYVREWRYLQLVTSLPCVFVLSYKWLMLESPRWLITVGKKKEAINVLTKIAKWNKRPTENIASIIYAAEEHKTKKEEPKYGSYLDLFSTPKMKMYSLIIACVWFCCGNTFYGINQYIGRLQGNFYLNIFLFGVFHIPPLFFNVLVSLYIKRKIGVIGSFTISAIALVIFIYIPSDLESISLAFAILGHIGSNMAFGQMYLFTSEVFPTVVRNSALGFASMFSRFGGFAAPFVVNIGIEWISVAIFSGVTLIAAFFCFFLPDTKDKVLLNTIEQAEKSTDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMQ0</accession>
    <name>A0A194QMQ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMQ0"/>
    <dbReference type="InParanoid" id="A0A194QMQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="28952" checksum="106F58D7DEE3E5AD" modified="2016-10-05" version="1">MARGSLSENERHCLDSSAKTQPQGPQEADRAHDKPGGLRVRFLDEEGKTERTVSADEVDCAVGRVKKIHILKNRSSSETSILLRNPSLAKRRTAAERRFSDGHTDSLNNNSLSENLNGKIKQTESEKSERADDTKESNQSFKKNCNVYSVNQAKTLTPERKKSIPLGIPKLIGHREGARADHGRSSLPGEACLAEGAGAVGKDFTVRAFGRLSRGLGRLLRRSNSVKISEPDPVYKVAYLGNVLTGWARGELTLHHNLCYKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMV5</accession>
    <name>A0A194QMV5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="127"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ06699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1634" mass="183686" checksum="4868841AFD709290" modified="2016-10-05" version="1">MASPSPQNSPMPPPQAPSPMGPPTQSPAPPQSPHSPYNPQHINGPPPSHAPSPGQPQLANHMPTNAPPHTIASSANGAPSVPQQHPSMSPVGHQLPPHMVGPHIPGPPGHPGSHPPGPNGHSSIPSPSQHAAIPGQGPGYMQHQLGHMPPGQGPPAISMPGGPPPPGNGLQGPPGVPLPLGGPPPHGVHPSGLPPMPPHHVMLQSGGPHSGGYAHAPSPGSSAPANTPPVSQPSSGTPIQHPPSAQTPPHGQAPPPSTSSANGAPPSSSPMQGSLPAPGPDNLHALQKAIDSMEEKGLQEDPRYSQLLAIRARTNPQDPNKGLFSNTQLSQLKAQIAAYRNLARNQPITQQIALMAAGKRAGEAPPECPTPPAQPPSPYAQAQPQPGKAAGGGGAPPTPLPMTGQMAPPTQPTPPLVNPPGVPTPGAKQNRITSIPKPVGIDPIQILNERENRIAARIAHRIDVLSNLPANMADDLRLQAQIELRALRVLNFQKQLRAEILSQVRRDTTLETAVNIKAYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHQEFLQTVLQHAKDFKEYHRNNVAKLARMNKAIMNYHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYIASLTEMVKQHKQEQRKKQQEEERRKRKSRKKKLLEGGEIDALDDSSQTSDTRVSVVDPKTGEILKGEEAPLLSQLKDWIEAHPGWEVMSDSEDSGDDSQDDEKKGRKDKHKDEKSDKEKTDEEKARDMIKKAKVEDDEYKTEEQTYYSIAHTVHESVTEQASILVNGKLKEYQIKGLEWLVSLFNNNLNGILADEMGLGKTIQTIALVTYLMEKKKVNGPFLIIVPLSTLSNWVLEFEKWAPTVTVVSYKGSPQSRRLVQTQMRSTKFNVLLTTYEYVIKDKAVLAKVQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPHRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPDKVEYIIKCEMSALQRSKGVLLTDGSEKGNKGKGGAKALMNTIVQLRKLCNHPFMFPHIEEKFCDHLGTGSSVLTGPDLYRVSGKFELLDRILPKLKRTGHRVLVFCQMTQCMTIIEDFLSWRGFQYLRLDGMTKAEDRGELLKKFNDANSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMIVNSVESAHASNQRKSFLYKLNMDEKVIQAGMFDQKSTGSERQQFLQSILHQDGDDEEEENEVPDDDLINEMIARSEEELEIFKQIDIERKKTESQSRLIEESELPDWLVKEDDEVVCNKGQGWNYLDEDETLGRGSRQRKEVDYTDSLTEKEWLKAIDEEFEEEEEEDDDDEVLDKRRKKGRKRRRQDDSDEEEAPCSSKKKSKTEINQTKKRLKSIMKKVIDFTDDAGRVLSEPFMKLPSRRELPDYYDVIKKPLDIKKIMNRIEDGKASISYSDITDLERDFFTLCANAQTYNEEASLIYEDSVRLRNVFIEFRRRYDAAQNSDDSDDNDKDEDDSDGESNRSVKMKIKLKGKSKNTPTRKRKQRKYISDDEDYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP66</accession>
    <name>A0A194QP66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Equilibrative nucleoside transporter 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP66"/>
    <dbReference type="FunCoup" id="A0A194QP66">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719117"/>
    <dbReference type="InParanoid" id="A0A194QP66"/>
    <dbReference type="OrthoDB" id="10014563at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="555" mass="60972" checksum="DB0599C68BC5A273" modified="2016-10-05" version="1">MNETLGRGYARIDAIRAARGEPLTAMPEPTGPPPDRYNSVYVTLFVAGTAFLLPFNSFIMAVDYFQHHYPNTTIMFDMSTVYITSACVAVVINNLMLDLFTYNTRITFGILLSLATMLFVAICNIGWDGFSTNVSYTINLVAIGVVAFGCTVQQASYYGFTGCLPPRYTQAVMAGESAAGFWVSIDRIITKYGFRQPRRSTFMFFVFSILILLGHSMLHHVMMRHPLVQYYLRLTNESRHRRRIQLHLNPNEDATLMESESGDGAFGVLKLQSPALSNTGTVDGENTFSFANPLYSPTATIPVTSAPLASPPPSVSEASPALRTPRPSYKVEDVVVESPERPASWRSFKRGVLARWAVARAIYPYMVSIGLVYFTTLSLYPGIASEVPSCRLGSWMPIILMSAFNSFDFIGKIAAAWPYEWSRSQLLMASGLRLLLVPLMLLCAAPRHSPHIVGDMYPILFSVVLGFTNGLFGSVPMILAPSRVGREHREIAGNMMTLSYNGGLLSGSLVSYLLLSMLGPPAGAPCRTYPTPPLPTLPPLTTSAPNVTYILSSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP87</accession>
    <name>A0A194QP87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM100A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBALD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP87"/>
    <dbReference type="STRING" id="76193.A0A194QP87"/>
    <dbReference type="InParanoid" id="A0A194QP87"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14343">
        <property type="entry name" value="UBA_F100B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039310">
        <property type="entry name" value="UBALD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31993:SF4">
        <property type="entry name" value="UBA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31993">
        <property type="entry name" value="UBA-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="16812" checksum="23317624D31F5DC8" modified="2016-10-05" version="1">MDSALREQVMINQFVLAAGCAREQAKQLLQAAHWQFETALSIFFQEVAIPSGANGIAAQHYHQQLITPCNTPATPPNFPDALAAFSRLSTTGSPSNAGGGGSTMAPPVSPLATHPPPHNQHTPMQVNTFQSPPNPQNNYAPLSCSTASDQAPAGGERGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR22</accession>
    <name>A0A194QR22_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR22"/>
    <dbReference type="InParanoid" id="A0A194QR22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="19989" checksum="047D7B1A54CD22E4" modified="2016-10-05" version="1">MTETVTNTNERKSLFSSFLEVLEARDTQIQLERQLEEEKYQRRTQRIYDFHERQRREAVELQRCLQYVSQHAHVLESVLRGAGAGEGVPLAAALLRQAAALQRSMAQCVANAARIRQLLTAAHRPQMDTMLAKMVSLSALFCTIRQLTVESDRYGSKRLRRFRLDVVLTKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRD5</accession>
    <name>A0A194QRD5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH oxidase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRD5"/>
    <dbReference type="STRING" id="76193.A0A194QRD5"/>
    <dbReference type="InParanoid" id="A0A194QRD5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="579" mass="67350" checksum="B30202B3AB821E3F" modified="2016-10-05" version="1">MYIFYDSFIFYKRERRFYYLRQMLGLGLCISRGTATVLNLCCALVLLPLCKKLNQLLYRLLSKLWPGLFFFWLERAKSFHMTVAITLLLFAVIHSMSHFVNLWNFSRNYDEQRADINLARYKNESPFLLLMSMAGLTGVMLLTIAICMGLTSLRVVRRRVYNAFWYTHQLYMPFMVFLMIHPLSGVLKEEVLSEHRTSLFSSQVTSWSNGSAPHITKFVPIKSKTWIWMAVPLSCFLVDLLWRIFTRNLARVQLLNASQLPGRTLSINVSCPHDTFSCRKGQYVLLQCLDVSLLEWHPFTIVKLPTINQRDFEVWIRVKGDWTEALEKLILEKGANNVRMLIDGPFSSPMEGVSRSDVALCVAAGVGITPFVAILHDMLINPRSTLPGRVHLLWIVRQEQELKWLADLTHKVISQLRHANRPDRLHIEFYVTSTNNNDPNTTYDKDKNNIAHVVMINEKGVLTHILNKNDKNMADDEKATLLTPNRKRIDYVAKDKKDDYTNKKGYDIAKEYPLVGCRVRRGRPHWDRVFGYWVHLYPEKNLNLYCCGPKKLVKLLRNKCKIVSNETKNKFTFIHEAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRQ0</accession>
    <name>A0A194QRQ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRQ0"/>
    <dbReference type="FunCoup" id="A0A194QRQ0">
        <property type="interactions" value="1655"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRQ0"/>
    <dbReference type="KEGG" id="pmac:106720223"/>
    <dbReference type="InParanoid" id="A0A194QRQ0"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="43315" checksum="6896207DD85ABDCF" modified="2016-10-05" version="1">MKLTHRNIEKDGCGSIGLIPEESEDMWHAYNLISEGDAVTASTVRKVQTESSTGSSTSNRVRTTLTIRVETIDFDTQACVLRLKGRNIVENQYVKMGAYHTLDLEQNRKFVLQKVLWDSVALERVDTACDPSATADVAAVVMQEGLAHVCLITPSMTLVRSKIDVTIPRKRKGFVQQHEKGLNKFYDAVMQGILRHIDFSIVKCIILASPGFVKDQFFDYMMQQAVKTDNKLLIDNKGKFLLVKASSGFKHSLKEVLQEQSVMAKISDTKAASEVKLLESFYTMLQLEPAKAFYGKKHVEKANEALALETLMISDKLFRCQDVLKRKEYVALVDSARENGCDVRIFSSMHVSGEQLDQLTGIAAILRFPMPELEDSDAEDDSGTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRS1</accession>
    <name>A0A194QRS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative histone-lysine N-methyltransferase Mes-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRS1"/>
    <dbReference type="STRING" id="76193.A0A194QRS1"/>
    <dbReference type="KEGG" id="pmac:106718755"/>
    <dbReference type="InParanoid" id="A0A194QRS1"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05838">
        <property type="entry name" value="PWWP_NSD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PWWP" evidence="1">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="48835" checksum="44E8BDE3562454D1" modified="2016-10-05" version="1">MSILHWKLGDIALARICKKVYAKVQVIKDEKGLFFDDKVLAISPSEDGINVTTQLCYYVETIRTKNKMWLPYTCLHLAARSRPFYGPSEKLPVPIKIKPPSVPRKRKIKEDHTLPLSVKPLKSREPDLNMTYDIRHIPLKQGKYENAFKEFVRRGKEMLFDEFYSQLQDNKENEECLYYVKNIDASTEDKFEMIIKNTVSEKEIENYLHQCWRYNLVHKQTENKENIDNNKSLSPEKMPITLHVSWCLVCGKGDRLRQCPNCPSSFHLACRREWLVTIIHRKKLPNKAQKQMTFVDKILSSTRTICSVKKEKENVELCPSCMWGPKVGYEDVVWHKLGACPWWPARVLAPGAVPSCLLSRSHTPHQWPLKYYGTENHSWGDSGRMCLFLPSHTAALRSRDETLQRALLDACDDYIAVYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS93</accession>
    <name>A0A194QS93_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS93"/>
    <dbReference type="FunCoup" id="A0A194QS93">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS93"/>
    <dbReference type="InParanoid" id="A0A194QS93"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="35050" checksum="2CA0D5601C4CE73F" modified="2016-10-05" version="1">MRAIGSVVNVVIRRTYVIESTTSFSAIVQQFEQDGYVVLEDFLRGPECDELVEAGLELTKQAAEIDPKPIFSTVDPEQAQHKDAYFMESNDKISYFFEADAVDSDGKLKVEPSISLNKVGHALHLLHPIFRCYTYSERVKRVCRELGLVDPAVVQSMYIYKNPGIGGEVIAHQDSTYLYTEPIPPVGFWIALQDVTVQNGCLWISPGSHKSGIHRRLIRNPDKDSKQAIIYDRPAPVYPQSSFTAVPVPKGTCILLHGNVVHKSAPNKSEKSRHAYTFHAIEKHQNTYSPDNWLQEGPNAPFVNIYTTSQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSD9</accession>
    <name>A0A194QSD9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSD9"/>
    <dbReference type="InParanoid" id="A0A194QSD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="575" mass="66020" checksum="6A8F8A188BEB8AF6" modified="2016-10-05" version="1">MLRYVLCMLMKPISTRIVQMEAIQADTILNMEEYNFNAPINVKIIYDDDEETSEGIMTQNKNAQVERRQWGNMSYTTVGSNLGEQAQVEAFKGINSIVHSDTLKVVIENMAAIIGARFKFQQVYKTLSTAEVQRFKSKYIEMKYLLFKRSMTVAKSLLLPQKSNEIFTETIVVEILQKAKVNNNMYSIVRLLYTDLIAWTETQLGREEKDVEAPKNLGLDMMQSNLNSGLRKRSHTSTEDTNALREMLRKKICQIETRSTEGGNSCPSFVSNLSSMVYSPPNLTTYHNPHENYLNEINGLNPLSMQEQQNYLSIRGHSTIEYQKTMQTNISQSSVDNSSHLEKNRYDGQDVSRSSISRDSGFTSPDILFSPQESTNTNYQDPSPWPTSTSTQNTPIPNISSNRRVVKNGPYKLIALHQGTRRRHWHIIYISANKQWGLTLDWEELFEKEPTKQQALTACLVYTSIFIPGMIAKYYKTFSATNISRLVSAPIIPEWSSHVQRSYDKWTTENYEAECSEGGNPIFRDESLTLQEEQSRMVDAIDEADERSIRQQLWDGSKIPRKDWQVLCGRKKKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTY3</accession>
    <name>A0A194QTY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dorsal-ventral patterning protein Sog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chordin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTY3"/>
    <dbReference type="FunCoup" id="A0A194QTY3">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTY3"/>
    <dbReference type="InParanoid" id="A0A194QTY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016353">
        <property type="entry name" value="Chordin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002496">
        <property type="entry name" value="Chordin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="CHRD" evidence="10">
        <location>
            <begin position="69"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="10">
        <location>
            <begin position="209"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="687"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="770"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="942" mass="103346" checksum="4596B38411879EBE" modified="2016-10-05" version="1">MSPLSLFLYFRREQIQQESYAKNKFCCRSHRRRRLDASPVTIEYHWTPDIVQEDSPTVVITGGEEEELSMKHFGALLTGRSPLCIRRDDMTGVAVAPGVATARFTFRRRHLFWSVLLGPSIVTQPRSLAFLDRGGRMLLEHPLKRSPGIHATYEEKTDKLCGVWRRVPREYKRLLRDGSLYVALIWGDERNNSMDKALSGRINRYPALSTEMFTTLLEPEHPPASIGNGACDDYRTLGQEGGWWGGTAIVTGAAGAAPSLHLAIIYNGIFTLSARDQSVRVLLTLPERNQTIIDEIQKVPKPGYEMNVLEVSTPVSAAELRSLSRGRLLLAVQEVGTVERRIVGPVRQKAACEVYHACLVAERAPASPAPEGLALIYIDKEGSLVYDIQVDNLGISDPKITLVEEQGKRHSQVEILDTRVGVLARPSARIFPPLYEDQLAVHIGADAGPPILRGRLLSRSLPDASVDNLGISDPKITLVEEQGKRHSQVEILDTRVGVLARPSARIFPPLYEDQLAVHIGADAGPPILRGRLLSRSLPDAAGLGPALLRRTDARTPTTLTPMAGLAWLSVDSLCGIQYEVVVTGATGAWSSWLETHSGSTRALGGAEGCVLEPAPAELAALQAGTAHLNVRAADNVTQLLRTRVPQISVPPSCLPTVPWTSDNELGAGYSPTHVEAPPPDNSLTNTASCYYAGRFYEDGAQWMSTESCQMCGCVHGVLRCDAVRCPRVTCATPTIQPPGQCCPICTRKYTMFLCFLLFDDSTTAVWNESHGCHLAGQYHAPGSSWHPYLVPDGYDLCAVCTCDFATRQVRCPRVRCPPLRCAEKDAYRPDKKACCRVCPEEKIKKVEEETPKDQGAPRTAEEILAEGGCKFPDGPLPNGKEVHPSIHSHGEQRCVTCRCKDGEVTCVRKRCGRAACARRRRGDSCCACARHRRQRAPRPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU88</accession>
    <name>A0A194QU88_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU88"/>
    <dbReference type="FunCoup" id="A0A194QU88">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU88"/>
    <dbReference type="InParanoid" id="A0A194QU88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1790:FF:000001">
        <property type="entry name" value="roquin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000047">
        <property type="entry name" value="Roquin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="837" mass="93329" checksum="CD455024AF699FD1" modified="2016-10-05" version="1">MSETLLGDCCNLILRPHLTQQAERLGFAQFTPARYYALKFTKKYVNKQMRQVPKGRAQTASVVKFRFISVIKVAETETETDVEKRAELPHLRKRKQRMPIQAPQWTDYLSCPVCCREFGLPPRSPISLGCGHTLCKQCLKNLHRKQCPFDQTVIQTDLEELVVNTALLQLAGYRPPAVPYHPPCIQALPEHERRAYDSIVRCLEHLALYLYCSSGNNGMTGTRLSRPMQRKLVTLLQCAMTDEEGRGRAARAARSLGERTVTELILQHQNSQQLSANLWAAVRARGCQFLGPAMQEEVLKLVLLALEDGSALSRKVLVMFVVQRLEPHFPQASKTSIGHVVQLLYRASCFKVSKRECDSSLMQLKEEFRTYETLRREHDAQIVQIATEAGLRIAPDQWSALLYGDTGHKSHMQSIIDKLQTPQSFAQSVQELYIALQRTGDIAQLVAMSRHLNYLANIDVSPETKSPSWTQLSEIIASIKEVISCLHFCHHITIRDGNCALRHNGIDQSGRGINNKISYKMLTCSDSATREFCPRRNMCPYLHIEDEFERSEGNQGLVNNDGANNHTVPLAIRMPAPIPIAAMPQRQMTPQFVQPIPLPLPSHVPLTPMQLPAGVPLHPHVPLPGHMYAQYPVAPTVPHTYNCVRPVSAVPLMQPNGAVMQNPTGPMWFNPFYAGYYPQPDGNCYPAPEFVPGGVMVPPGGYQNVEAPQPSAGGNAFVPQQYDAARTSPYSMDGGQMECSPDYNVNPFSFHQNNVNQVQSTWSQPNNVYNFADVRNALDALSAVDEIFAGPPTSATTNNLVTTPHIAADLDGSDDQELEEEMQALEIRIGAVLKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUP6</accession>
    <name>A0A194QUP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-deoxynucleotidase HDDC2</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HD domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_06188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUP6"/>
    <dbReference type="STRING" id="76193.A0A194QUP6"/>
    <dbReference type="InParanoid" id="A0A194QUP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="24056" checksum="9B5AB1C1EBB1D35B" modified="2016-10-05" version="1">MALIIENQKILEFLELVGRLKHVKRTGWVLCNIEDCESIAGHMYRMGLMTFLLTEENNPTKLDRFKCLQIESSLLSALVHDLAECIVGDLTPHCGVSPEEKHRQEDEAMKKIAELTGIAGDRMYDLYKEYENQSSPEAKFAKDLDRYDMILQAFEYEKRENAPKKLEEFFKATEGKFNHPFIKELVKELYRQREEFEKKCLLNGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUV6</accession>
    <name>A0A194QUV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transient receptor potential cation channel subfamily A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_15240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUV6"/>
    <dbReference type="FunCoup" id="A0A194QUV6">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUV6"/>
    <dbReference type="InParanoid" id="A0A194QUV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="905"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ09099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1263" mass="142312" checksum="141960B62544A05E" modified="2016-10-05" version="1">MWLFNAGTIVSSAPVQSASPQEPDMNVIEQDAPTQVAVNISSSQPTPLQQPRIGRLWGWLEWLTGRRHKQQENIDHGGELQCMLPGSDRANVGEICLLAESPYRILRAAESGNVEDFMRLYVNDPSRLSLRDPRGRTAAHQAAAKNNANILHFINKYGGDLGSRDNAGNTPLHVAVENEALDAIEFLLQQKVNTGILNEKSQAPIHLATELNKVSVLELFSKYKNVIDVDLGGEHGRTALHFAAIHDHDQCARILISDLGANSKRSCNNGYYPIHEAAKNASSRTMEVFLQWGESNGCSRESIISLYDSEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALEIIRLMFEMQPKEKKACLVSCDVQMMTPIHCAAMFDHPDIVSYLISEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIKLKDMNSRNLLHLVVLNGGRLEDFAASCKDHCEQGLIQMLNERDNTGCSPLHYASREGHIRSSENLIRLGASINPKNNKNESPLHFAARYGRFHTACRLLDSDKGTCIMNENDGEGLTPLHISSREGHTKVVQLLLNRGALIHRDHNGRNPLHLAAMSGYTQTIELLHSVHSHLLNQSDKDGNTPLHLATMENRPNSIALLLSMGCNLTYNNLDMSAIDYAIYYKFPEAALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAVQDKCITKANCKKDSKSFYIKYNFEALCPQVNYEEGPRNRKSDNVPKSQEIPLPALNIKYYFKHYQYSKLEIEAQRQARGDPNYRPEPLSVINAMVAHGRVELLAHPLSQKYLQMKWNSYGKYFHVANLLFYCIFLSIVTLYTYLLMDSVPNTVLSNNSTSACTSWSSDFNNSAKNTSGWDNLSSERADDFQRTIAMDISTVAILVYNSICVVREAYNVKQQKWHYLVDPSNLVSWILYISSTMTVFPWVFTSNCSVQYSAASITIFLAWFELLLLLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIMAFGLAFYILLSKGNHLSFSTIPMSIMRTFAMMLGELDFLGTYVHTYYRSDSDASLPFPMATFFILGLFMVLMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPAMLLEKVDKSELIEYPNSNKCKLGFLDLILRKWFCNPFTDDNGLDLVLENKEDILTSELIKQKHEIRNMNRIINQQYMLIRLIVQKMEIRTEADDVDEGVSANEIRVVPRWSSPRLRNNLRPASSFNRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUW1</accession>
    <name>A0A194QUW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SOSS complex subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUW1"/>
    <dbReference type="FunCoup" id="A0A194QUW1">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUW1"/>
    <dbReference type="KEGG" id="pmac:106717190"/>
    <dbReference type="InParanoid" id="A0A194QUW1"/>
    <dbReference type="OMA" id="YVEKPNM"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="162" mass="17939" checksum="B940D4AC5CFA7097" modified="2016-10-05" version="1">MSATDYVQIKDIKAGMRNINSIFIVLEVGPPILTKQGHEIRILRVADPTAMINFSVWDEAGALLQPGDIVRLTRGYAALWRCSLTLYSGKFGDIQKVDEFCMVFNDELNMSEPQPALAAMSQGQQHSHAAPLSLMPNAASGDQVNNSKQEPFDSQQKHKSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUW7</accession>
    <name>A0A194QUW7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Glutamine synthetase</fullName>
            <ecNumber evidence="2 8">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 8"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUW7"/>
    <dbReference type="FunCoup" id="A0A194QUW7">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUW7"/>
    <dbReference type="InParanoid" id="A0A194QUW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF44">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="9">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="10">
        <location>
            <begin position="195"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="444" mass="50245" checksum="01238928ADA04A98" modified="2016-10-05" version="1">MSDAGHGKIEDNPKILSGPVLTNSPNAVLSKTLLGRYNDLPLPGDKVLATYVWIDGTGEHLRCKDRTLSFIPKQPKDKLTRILENMYTKYELSVIGNLKWSYMDEYSSPYYFPRDGPDTSILCEQKLNRDSFDENFKDLPVWNFDGSSTGQADGHNSDTYLVPRALYRDPFRRGNHLLVMCDTYKYNMEPTESNHRVKCQEAYEKCKDDEPWFGIEQEYILLDSDLRPFGWPPGGFPPPQGPYYCGVGANKVFARDLVEAHYKCCLYAGVPISGTNAEVMPSQWEFQVGPSVGVTAGDDLWMARYILHRLAEEYGVIVTFDPKPVQDWNGSGAHTNFSTKKMREENGIIEIEKAIDKLSKVHMKHIKVYDPRGGKDNERRLTGLHETASINDFSAGVANRASSIRIPRAVAEEKKGYLEDRRPASNCDPYAVVDALMRTCILNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW49</accession>
    <name>A0A194QW49_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proton-coupled folate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW49"/>
    <dbReference type="KEGG" id="pmac:106716795"/>
    <dbReference type="InParanoid" id="A0A194QW49"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="519" mass="57185" checksum="AEAC146735DC5529" modified="2016-10-05" version="1">MQNKTISELELTENVNKDQGAYTNKKEDIDRKEEGQEQVSWLDRVKIILKFFTVEPFLLCYIMPNVISSLAVQKLNMEKACRSDLNYSEEICSLALSGEVSDNITAAALSGAQKMVADMTAWKQPLQSGIPAIVILFVGAWSDKTGNRKALMLCPIIGELVSAIGLLFATYFFLEWPLWATALIEALPSAFSGGLSIALMGSYSYIADVTTVESRTFRIGVVAVIVTLGIPLGSSISGVLTEAVGYYGIFGIGTLLYVLAFLQTYFRVHDVRRVEMEGTFKEKVIQFFHPKHVWDTISLLFTSARIQLIQIVLVICAHIVIIGPVYGESGVMFLYTLKKYNMTVVEFSLFMTYSILMGLGGTAVAVTVFSKYLKMHDALIGVIATICKVASSFVYSLAPTKAWFYSGPVFDFFGNSGTTAIRSLGTKVVDQDKVGKMCSLIGFVEAIVPVIYSPLYSKVYSATLDTFSGTFYLLGGFMTVPAFLIFIALYSIQRRQARDQVTDPNAKEMHAHDNAATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX26</accession>
    <name>A0A194QX26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RBBP6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QX26">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QX26"/>
    <dbReference type="InParanoid" id="A0A194QX26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000070">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1115"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1436"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1471"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1610"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1685"/>
            <end position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1708" mass="193335" checksum="36295C8C11C741C1" modified="2016-10-05" version="1">MSVHYKFKSALDYDTVTFDGLHISVGDLKAAISQQKRIGKTSDFDLQITNAQTKEVYVDDQTLIPKNTSLLVARVPLAQQPKKQWEGSNGNSSSLHKDVAVNKGVADLSRMEGSEQDKINAMISQSTFDYDPSNYQKIRGQNQRGAVPSNYICYKCQKKGHWIKDCPAANSGEAIEIRRSTGIPRSFMVPVDGPKAPGAMMTPSGTFAVPAVDHEAYLASENAGGADTPTNAPAAPEPTIPDELICSLCRDLLTDAVMIPCCGNSFCDECIRGALLESEDHECPDCREKEIAPTTLIPNRFLRNSVSAFRNQTGYSRRMPHRPSAAPPPQPQPPPALVPPPVIDVIPAAPVQVNGPPQEVAANADAVGGGGRGVGGDENGERRAGAGRGGHGGGDVSESEGSGDDNIVVTVPPAHHAHAHAHAHAYPHAHSHQHPHPHGHPHAHPHGRRHNMHRPTRLGPLPGMKPPGLDAPPINVMFNRGQPPPFVPGLPPPGQRYPNQPYGRHGPPGPVYSDRYRHRLEPYQPPHRALRIPPPTVDRDVYVVRRAGEDPLEAFNRMIREKEMRAKRREEERRRAHSGSRTPSRSRTPRSPRSPRSPRSPRSPRSQRSPRSQRSPRSLRSPRSPRSPRARPRSRASSRIRYTRSRSASRGRVRRSPWSPRRRRTRDRSLSLTRSPSPRRRHRTPLRYRSPLRSPGPRSPPLRSPPLRSPLRTPLRSPLRSPLRSPIRSLPHSPHRPPPLMRSPQPRPMSPHRYAGVYDELLSPPRRSVEPPYGARYGPRNNAPPPTFPPLGAKPIPLLGSLPARTEPPPGYRGRFDGPPFEDIPPGVEPPVPGFEPSPFEKPSFGPPGPLERDRISGSGYRDGYRAPPYADGPAGYRDMPIPPAQNEIPVHIPDQAPRYRDNYRPGHGYRDQGPAPFRDAGQSYRDSGPPGLPYRESNFRGGPPPSFRDNSYRNMPYRDGNYRDTVPHNFRDPNVPYRPPSADPREPVPPNYHDANYREGFRDENNGGRDAMRPGYRANTRSRGGSRRNPNLEHDKHRDARERERFTENRDPLPEKGERPRDIEKRQAYEKREVRDERTREPERNREYDKERGRDKVTPDKKVRLSPKRTREKKRSESRGRSRDRDREHRRDKKDDRSRERPSSERGRDHKDKEKEKKIKDRKKKKREKEKDTEKKKKRDKKERKEKESTKKDDEDKEKTDSQTENNEPDKQELKEEKAITNNVESEQVLAKDIKAEKSEPVVEKSNEDLYGGESAEAVDKEIIQNYVKTENKDQSTEVQTVESSNKDEPFDGIELQAATEDLDTDIEGNTGQSKEMLAPLPELSKWEVDDDNAEKTKEPGEITSPEEEEDTGKVTSEVIKRAENAIFAKAINSLRPIEIKKISSDRLKLYGDEMQQKNSMNNIQITVPVVDSDQRSIELSDRNRYSKTPPPRLSVKERLGGKVEDVRKSREMRLVQSTVERVKSRSKTPKREQAYRRVTVEKEKENKTGSHGRSESTKSERRVDKEDSRNSDSYRGGGDSKKKEFDRNIKHDKKSNIEDNFGSRHRDRGNDNSNDIKRSNAERERKKSILDEAHFEPDYDENLESDNETKEDSSKKRERSASPSGAGEAKKAKLEDTIKLDLTNVKKKPESESESSSESDGSSSSSSSDARRRKKKKKRNKKKKKRAASDSDSDSDSSSDDHKKKKKKRKHKKRSNKKKKKSKHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYU4</accession>
    <name>A0A194QYU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYU4"/>
    <dbReference type="InParanoid" id="A0A194QYU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="24605" checksum="3518B413F9A9F919" modified="2016-10-05" version="1">MNRVWRFILLDTVRYRLKLLRIRLEEDPRCNYYLYVKDMRNYTENKIKFCLHLYRRIADMVDLITPELLNGSIFVSVVCSLPKLIINVYHILLVFEGHEETFSAGFIVMHIFQICFFIFSPCIVVEMYAMEVEKIRLFLMHRLIDEKDTKIKEDLHIFFDYTSIRTFRYKIWRCFPVNICLPIDIASICTSYVIVLINFTHLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZL5</accession>
    <name>A0A194QZL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0465 protein C5orf33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZL5"/>
    <dbReference type="FunCoup" id="A0A194QZL5">
        <property type="interactions" value="1606"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZL5"/>
    <dbReference type="InParanoid" id="A0A194QZL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="331" mass="37545" checksum="784202AB927FBCBE" modified="2016-10-05" version="1">MSVLNNFSVSVAKGLRRLRQNKELSERLLPGASTRRHGSKDGNTRLKMDKCLIVSKVTRYEYERHSHDYISDSELETVLRKRGSDFDSMLANHKEQKAFEENVAKRLREMGHQVEMASRYPPMSNIHENQDAQTKEHDVTTANSPTLSTKVLPFLALNEVFIGESVTSRVSLLRLQIDNGQWTHTKSSGLCVTTGTGSTSWHFSINCLRTHSVLELMKILGEEFDVKLETSVERAREVAERYNQKLMFAPDSDQLAYSVREYITFEEWPVPRGLRVRDRAAAVRVRSHCTDAGLVIDGSVSFPFNDGTQAALSVHPEDSLMTVHMDDTLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R011</accession>
    <name>A0A194R011_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R011"/>
    <dbReference type="InParanoid" id="A0A194R011"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="18501" checksum="1CD345C8CECF2B43" modified="2016-10-05" version="1">MIRRAPPALAAVAARRTVARATPHYAHKPWRERSELGVAPWDTEYIKDHRRNWNVESTTALVDKELGSPQARVAMDRWSGNSNAWSAALGAMGGAGTVLLFAAILLMWRRPRRTEPHILAPMDVGQNFLLSYTMTLKDDHHMLTFNAGRLQHLLHELADSSGEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0A0</accession>
    <name>A0A194R0A0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0A0"/>
    <dbReference type="STRING" id="76193.A0A194R0A0"/>
    <dbReference type="InParanoid" id="A0A194R0A0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="30333" checksum="E0D8671EFE284044" modified="2016-10-05" version="1">MSIEEKFNAAVNVIRSLPKSGSYQPSNELMLRFYSYYKQATEGPCDKPKPGFWDVVNRAKWESWNKLGNMTKDEAMQAYVDELHKIVETMSYNSDVASFLSLEEDDQNCLSNDLELVAGDVLARVRSVHNTPIGSRSVSGASSPIRSASPPRNRHDSDDEFIDTVDVSVEIFYRYSMKHKNKEPSFIGQPDRPPGTIPSGWLATLESSGSREFFCRALWNGLSSAVFPNQYDLGSFSRSERITFLKNGNAAFPLVLQMSMGLGSPWCSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R116</accession>
    <name>A0A194R116_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein still life, isoform SIF type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R116"/>
    <dbReference type="STRING" id="76193.A0A194R116"/>
    <dbReference type="InParanoid" id="A0A194R116"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="531" mass="60170" checksum="ED2CCF998A4029DB" modified="2016-10-05" version="1">MYFNILELNILCKKSRESEKHAMHHHNVINNNTSGSRRTKSKSTEDMNMDSSTLKRMLKPMPSTESPVTSPEMGRRRYGAACPPTCAHAHSHRPHPHPHAHPHYSHVNNNSRQSSQRRGVGVGAAPSGYPGRGLYLELGGGERDLSPPSDNVMFDNQCYATTPSSSNGNSDQEPCQRRDPRMHHHPKPCLSRQASQSSATPAPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMEDLEYNDNMPPSNQRSPYPPRRRPASQCSGGGSRSSTLPLPHRLGVERQHSARSDRDGYYSDRNELMRERERERERERGYLSDHNTRDRNRDRDQGYLSDHQSSFVSASRCASCIGESARSAWYRHSDGWRGQPPPRRSPWDSLPSLRHEGSLNDSGYRSNRADSFEQRGVFDRQDSVRSEYASDRESTRYGIVQQASVDSTDSRICYLTSSEREALQMQVSGNEVQRSNHRANWDSKLLSIMLDLSEPFAELRLNCFTNNEDTPLSSLCFNYPYSISTKESINACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1M6</accession>
    <name>A0A194R1M6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tissue inhibitor of metalloproteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_15063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1M6"/>
    <dbReference type="FunCoup" id="A0A194R1M6">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1M6"/>
    <dbReference type="KEGG" id="pmac:106714995"/>
    <dbReference type="InParanoid" id="A0A194R1M6"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03577">
        <property type="entry name" value="NTR_TIMP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030490">
        <property type="entry name" value="TIMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00288">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264848" evidence="12">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="13">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="200" mass="23088" checksum="229AEC62CF29F32B" modified="2016-10-05" version="1">MLTRWVTLALVAATWRAADACSCMPQHPQTHFCKSDFVIVGRVQKLFRGNDTYDAYKVKIRNIYKTTPKAVVALKSGRLLTASHEALCGVSLQPRETYVITGNVVHLQAHIDFCGYVNKWRDVTPRQRKGFRLLYKQGCTCKVHVTRRRTKSPNTCVTNYDDCFERHGICLHDRDRRCRWTRAPALTRCLQKPHFNSTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1Q8</accession>
    <name>A0A194R1Q8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane and TPR repeat-containing protein CG4341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1Q8"/>
    <dbReference type="STRING" id="76193.A0A194R1Q8"/>
    <dbReference type="InParanoid" id="A0A194R1Q8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="29888" checksum="9DCE1E132B94C201" modified="2016-10-05" version="1">MADGRLAEAASALRTGARVEGLRVRDRREHDAARVSALVQLATLHSQRGHWHKALSAYKEALQILPDTNAPVVGWTRHSVLSMAGDIYIQLQQWPQAEHSILSALAVAPKDLGTHITLAQILARNTSRALEAEMWFKRAVTLAPDDPSVRDQFGMFLRSQRRLRESAEQLVRAAQLSPEDGARAAAAARALRDARRCRSAERWYARAVELNPEDAAYHSNLGAILHLNGKYAAAAASYRRALQLQPNDEITITNLKRVRTLMSKQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2T9</accession>
    <name>A0A194R2T9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2T9"/>
    <dbReference type="STRING" id="76193.A0A194R2T9"/>
    <dbReference type="InParanoid" id="A0A194R2T9"/>
    <dbReference type="OrthoDB" id="9994380at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41148">
        <property type="entry name" value="LP09875P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41148:SF1">
        <property type="entry name" value="LP09875P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="648" mass="75928" checksum="8FBBF99FC0D8DB57" modified="2016-10-05" version="1">MALRLKKDIKKASYYVWFLGAQESRGLRGEEFALPAIRVLEERARDLEPFKVTLQVSHKGLKIIQNVSAKGKQQTIKHFIPHGSITSAVVQGDVVACVLLLYNPITGCPVHVHAYRCDSDHTAEMLYTHLQALIERPENQKKFADIERKLQMRGALPSKKPPDSSLGSEVSRESDSGSNEERCVANLYDSLAAELKQKLSTGKSPILLPPRDYDTVHRQKGNLSNIDTRRCLNQNIVGVNARRKLESSGGSSGIGSDLAPSPERNDYTRQHDNHSTSEEDWAESTAYMMHEAFEASPPRRAASPPRAASPPRRALSPRGYERGYNDDYLAPVEPFRDQLAPFRDATFERRFRHESLERGAKDKPDKFLDDATGYRRRYVPDAKPSNRSIDRGDDRRFGKLQRGASEGSLKLAETSPKDRFNVAKEKFMNLERERFNRELEQHMAMRRSMLERNSRSTSSPEEERRDERQERHRELSSRREPDRSHRDIERSHRDSDRRKDIERVRDVDPADLGHREMERLPRVGRKRDEKRYEYGAEDYLNRIEPKPEREFDRYRERRELDRRIEEDEIEPVLEERRREWTDRQRAFSRSRLLDEQRVAYPEGDRDRDRYYDREYRDFRELAERQPTKFRHSYAEPIPRGRLGTVRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3B5</accession>
    <name>A0A194R3B5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_06389</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R3B5">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3B5"/>
    <dbReference type="InParanoid" id="A0A194R3B5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="575"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1125"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="312"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="590"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="944"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="1072"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1312"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="874"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1551" mass="173409" checksum="5C5D75D4B217A9B6" modified="2016-10-05" version="1">MSYNSTLDDFCGSTFWDSNLTWYTDNPEFTPCFEKTVLVWTPCLFLWVAALLEAYYILNSKERNIPWNILNISKLVITCLLIVLKFVDLGVTVHKSSKDEEVFNADYYSPIIKILTFALSATLLYYNRKFGMRASGVLFFFWLLLILAGLPQLRSEVVAHYKLMDDENVQYNFVSYMIYYPMIILMFILNCFADLPPKDTPYKYEKNQCPEGAAGFPSRLTFSWFDPLAITGFRRSLTESDLWALNPPDSSKEVVPRFDKYWARILQKREMSNGTKATYSKTSASVNFKPENEKKPASILPALCLAFGGQFFFGALLKLFNDTLMFLSPQLLKVLIEFVKGDEPVWKGYVYAVGLLACATVQTMLLAHYFTRMYFVGMRIRTALTSAIYRKSLRMSNAARKESTVGEIVNLMSVDAQRFLELTAYLNMIWSAPLQIALALYFLWGILGPSVLAGLAVMIVLIPVNGLIANRVKTLQIKQMKYKDERVKLMNEVLNGIKVLKMYAWEPSFEDQIHKIRNKEMIVLKQTAYLNSATSFIWSCAPFLVTFLTFFTYVISDPENNVLAPDKIFVSMSLFFIMHLPLGLLPLIVVSVIEVSLMSFGCFVLVNETEVLDSERAFVALSLFNILRFPLSMLPNVISNVVQTSVGIKRLNKFMNCDELDVNSVEHDKSEPDPLVIENGHFSWGEEQPVLRNISVRIPRGSLVAVVGAVGSGKSSLLAALLGEMDKISGRVNTLGINLSGGQKQRVSLARAVYHDADNYFLDDPLSAVDSHVGKHIFDKVIGPSGLLKDKTRVWVTHNVTYLAQTDLVLVLRDGQVSEAGTYQQLLEKKGAFADFLLHHLSDAERTSPEELDEIKQELESKLGSEFQNKLQRARSLSESASESDQPAAGDRTGSVKRRTPEESTPNELKEKNKLIEVEKTETGSVKWTVYKHYLTSVGVLASVVTILMNLVLQLFQVGSNYWLSEWSNDKTIISENGTLDKSKRDLYLGVNGGLGVGQVVSVSVSSLALYLGTLAAARALHASLLAGVLRAPTIGFFDCTPVGRVLNRFSKDIDVLDNVLPMTLRGWTSCFFSNVLKAPLQFFEVTPLGRILSRFSKDVDVLDTLLPSQASDVIYCAFEVLGTLFVISFSTPIFMSVILPIGLLYYVIQRFYVATSRQLKRLESVSRSPIYSHFGESITGATTIRAYGVTNRFVEESERGVDHNQSCYYPSCIANRWLAVRLEMIGNFIIFFAALFAVLDRSSTNAGLVGLSVSYALQITQTLNWLVRMTSEVETNIVAVERIKEYAETEQEAAWMVGNGPGATWPETGALQLERLTLGYRAGEPALRDLTCTVAPRDKLAIVGRTGAGKSTLTLGLFRIVEAMSGKILIDGIDISTIGLHQLRSRITIIPQDPVLFSGTLRMNLDPFDAYTDEDIWRSLEHAHLKTFVQGLQAGLRHEISEGGENLSVGQRQLVCLARALLRKTPLLVLDEATAAVDLETDELIQKTIRSEFASCTVLTIAHRLNTIMDSTRVMVLDKGQLVEYAPPEQLLQDKTSIFYGMAKDAGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3J5</accession>
    <name>A0A194R3J5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3J5"/>
    <dbReference type="STRING" id="76193.A0A194R3J5"/>
    <dbReference type="KEGG" id="pmac:106713762"/>
    <dbReference type="InParanoid" id="A0A194R3J5"/>
    <dbReference type="OMA" id="WADACLL"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="25083" checksum="18FDBB912F2C5161" modified="2016-10-05" version="1">MRDERAGPPRVRIAVIGSSRVGKSALIVRYLTRRYIGEYHSNTDLLYKQTVPINGMPVELEVIDVSGSNTDKFPAEQIQWADACLLVYSVTDRSSFEYATEVLNTLKKNPPQGSPAHGSTSATMPLALLGNKTDLDHLRQVPTKEGQAMSQAHGASFSEASVADNSGDLYRCVDRLLADVRLPQRTRKFSVTKMLGSLIGTTTNSSGTSRSGSVVACPRVPAPSRPPLAAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3P8</accession>
    <name>A0A194R3P8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tumor susceptibility gene 101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3P8"/>
    <dbReference type="FunCoup" id="A0A194R3P8">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3P8"/>
    <dbReference type="KEGG" id="pmac:106715773"/>
    <dbReference type="InParanoid" id="A0A194R3P8"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="331"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="249"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ10466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="45052" checksum="0DFFC1E8CE4FAE51" modified="2016-10-05" version="1">MANDEVVLKQYLSKYKHRDYTAREVISLIQVYRSLVYRLEAFVFNNGTRKDLLNLEGTIPVNYKGAFYNIPVSIWLMDTHPQNAPLCFVKPTPEMTIKTSKWVDSNGKIYLPYLHEWSPSGSTLQRLVQWMITAFGELPPVYAKPRNQPRPPYPFDPFMPQPSGYPYPQVNPQPGYSTATPYPTTSNPLPYPNFGTPYPGSVSTNGTPYPAATPYPPTTNFGPGTEAGGTITEEHIKASLLSAVTDKLRRKLNEQSQQSQAELETLRRTQQELCEGKSRLEDIFTRLQREKATLEKNLSTLQEKEKELEAAVERLAEQDGIEADEAVVTTAPLYSQLLNAFAEEATLEDAIYYMGEALRKEVIDLDTFLKQVRTLARRQFTLRALMHKCRQKAQLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4R8</accession>
    <name>A0A194R4R8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4R8"/>
    <dbReference type="InParanoid" id="A0A194R4R8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="164" mass="18458" checksum="34257F2630F4F8AB" modified="2016-10-05" version="1">MAKFSEFPTCCARLRCVVEVNGERIVQTRGQPGELFPDKPWKGQQNEPNPAVVGMGSIQQNTVGGEAQPQSAPGIFNSRGAGKQTDGNDINGRRFVDPYPSQQMQENPRRKRSTVYPIFDKNMVRESNAYQPQQVKLHGYSAEKYTSYFTNNIKTLSNSKHLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R582</accession>
    <name>A0A194R582_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Short-chain 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">RR48_10467</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Ya'a_city_454_Pm</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R582"/>
    <dbReference type="STRING" id="76193.A0A194R582"/>
    <dbReference type="KEGG" id="pmac:106713163"/>
    <dbReference type="InParanoid" id="A0A194R582"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000019">
        <property type="entry name" value="3-hydroxybutyryl-CoA dehydrogenase FadB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000258">
        <property type="entry name" value="Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 25" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="27">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="26">
        <location>
            <begin position="210"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="24">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071676"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00077615"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079904"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KPJ12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="33673" checksum="A4EDD4299A536BFA" modified="2016-10-05" version="1">MNQLGVITRQFSCSSAVQSAIKNVTVIGGGLMGSGIAQVAAQAGQNVTLVDVNGDILAKAQKSIGNNLGRVAKKMYKDNPQEAEKFVSESMGRIKTATDPVSGSQTADLVVEAIVENIDIKHQLFQKLDQAAPDHTIFASNTSSLSVNEIGAVVKRKDKFGGLHFFNPVPVMRLLEVVRGAETSETTYRSMMDWGKALGKTCITCKDTPGFVVNRLLVPYIAEAIRLFERGDASAKDIDIAMKLGAGYPMGPLELADYVGLDTNKFILDGWHKKYPDQQLFKPIPLLNKLVSEGKLGVKTGEGFYKYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R592</accession>
    <name>A0A194R592_PAPMA</name>
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        <submittedName>
            <fullName evidence="7">LIM and SH3 domain protein Lasp</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">RR48_10211</name>
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    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A194R592"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="355" mass="41362" checksum="D148A73488556B22" modified="2016-10-05" version="1">MVCESALPHYDAQIVHMRLRKIRKYLWPYYLYFSRTRMLPVWHKGCFKCQECGMTLNMRTYKGYGKLPYCEAHVPKAKHTTMAETPELKRIAENTKLQSNVKYHADFEKSKGKFTQVADDPETLRIKANTKIISNVAYHGDLAKKAAMEKQRQINENGELVDVATNDNYHQQIDNYATEMLPPSQPTNQPQKNHYQPPPQQPQPPRQYQEQYRPQKQEEYSYQYQKYDVSDQYQNHGNQYAYGQYQQNYGANTQPKIGRIQDYDPLSDGPRAPPNIQHASATVIYNSTRDGKQRGGQQVTQQQSRQIGRVTDLDPLAAEQPRPNNNHHPTNQRVYIAMYDYEANDSDEVSINITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R646</accession>
    <name>A0A194R646_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_14975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R646"/>
    <dbReference type="InParanoid" id="A0A194R646"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="58440" checksum="0A1BE70E261D5BB6" modified="2016-10-05" version="1">MLTAIADVKVLSNDGLPEKICHKCCTSLEKAYLLKTVAERTDRKLRTILAKAIQNVPTKKIAFDSFKDIKSEIGPLSVKSEPVWEMEINVDPPKTVETIDGKDIVIANTVIRKVDHELEETKGETDDNDKVDISWTKTTNDNFKAEVDTDDDDDVEYVPDDIYNDDDDDDYVPPTSKKNKFKKPKLCDIKVFKGKKAVVRKVKVLKTLEELEENGSKSEDGKTRSTTITCYPIMKNGTRGPPILLKRPKDATVLKVHPNYKSRNSGSSDGNRMVRRDKTVRMVRSQRPEAKKREKLVCPVCGILTYTLGNHLATHDEKKKFSCNQCTKSFIQKSNLMLHMKQHSGIKDHICEICGAGFYTQKSLIRHNLIHKGERPFSCHLCTKKFIARCDLNRHLRIHAGYKPYKCNECSMSFNAKHQLQNHERMHTGERPYTCEVCNVAFSYKVNLNNHVQKAHGLNFKFKSIHRVTEEVLRREMGMVNETRAAIAHIMPHLSDVPTPAAHETVHHTSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R781</accession>
    <name>A0A194R781_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R781"/>
    <dbReference type="InParanoid" id="A0A194R781"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="45" mass="5106" checksum="61518AA8559DCC75" modified="2016-10-05" version="1">MDFQSAMETFAEAWAAANTVKSEAPSDLSQDPCDFVRQYTPNWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAA0</accession>
    <name>A0A194RAA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAA0"/>
    <dbReference type="InParanoid" id="A0A194RAA0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="497" mass="58459" checksum="03E3A08136DDD2C9" modified="2016-10-05" version="1">MDNDVCLKKPYNLPSAKEIDPRHSYADEKFERLQEYYSYMNSRIKEPHNPKPYNLPSAKEIDPRHSYADEKFERLQEYYSYMNSRIKEPHNPIERREILETAQKRLFTFIDTHIKDLKRLLFETDMALMSMVLLKLNKKMDTSEAKIKSTQAKIPFGLYASPGVMFLMLFSSALGGNGDVSSFQLLARLSFPTVETKPYNLPSAKEIDPRHSYADEKFERLQEYYSYMNSRIKEPHNPIERREILETAQKRLFTFIDTHIKDLKRLLFETDMALMSMVLLKLNKKMDTSEAKIKSTQAKIPFGLYASPEFKCLGTSYYIASAHNQEDAQMILSSERKPHCYTFRGAFAFSGFYHRHSETTYVGPHAEQFQAKDPSQGLYCHSDDNWSDAQCIYKINPREEFPESVEYEPKVSYWCGPYRYFLPATTDVRCIFSIFSMNFILRFGYDGVSYKSSDLSFMYQNGQVFYTDEPWAGMSCWNWACKWRHNQNQRSNEFFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAA1</accession>
    <name>A0A194RAA1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET and MYND domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAA1"/>
    <dbReference type="STRING" id="76193.A0A194RAA1"/>
    <dbReference type="InParanoid" id="A0A194RAA1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="145" mass="16848" checksum="EC23CE75395F81BF" modified="2016-10-05" version="1">MKNNYKISDTPVKAGDLLLNENPFVYVLSSKEKGLRCDNCLQKSKVLKCSGCQFVHYCGRVCQKEAWSGHKWECANLKRVAPKIIPDAARMLAKIVNRLSRGDGQSYRAYYTKTSFRMWKDLMSRKCYIFVLKKKRKNAVKDRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBM8</accession>
    <name>A0A194RBM8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBM8"/>
    <dbReference type="STRING" id="76193.A0A194RBM8"/>
    <dbReference type="KEGG" id="pmac:106712788"/>
    <dbReference type="InParanoid" id="A0A194RBM8"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="32846" checksum="95FCFB70F744E2A5" modified="2016-10-05" version="1">MPTKVAVVTGSNKGIGLSIVKGLCKRFDGVVYLTSRDVSRGKAAVEKLNAEGLFPEFHQLDVTDRKSVERFRDHIKEKYDGIDILINNAGVSGGLNSANYDECKSIININFNSILILEELIFPLVRDNGRILNISSDCGHLSNIRNKYWIEQLSSKDIKMDDILRFVDWFLQSVKDNTFNKQDIADGGTVAAYRVAKVALSAATIVQQRELDKRNISINSMHPGLVRTDMTTGIGFYSADEAAKTPIYLVLDAPASLKGAYIWHDGKVLDWYDYNADYYFKISTVLDHLQKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC34</accession>
    <name>A0A194RC34_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MLX-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC34"/>
    <dbReference type="FunCoup" id="A0A194RC34">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC34"/>
    <dbReference type="InParanoid" id="A0A194RC34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="809"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="803"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111115" checksum="AFA9F15C9F2121B6" modified="2016-10-05" version="1">MTHVEKHQTRTGKETIHSGHFMVSHFEAEDQDDFDDLAVPVPDEEQTVQKNTVVAMYTVPGSSETYTLSDKEESKQHQQLSIEISLTKLFKCMSLAYRQKLTSPKWNRFKGIKLRWKDKIRLNNVIWRCWHMQFIKKQNTFVCQFASPLDVDTHVKPETTILEGKYWKRRAEAVIAEYKKWRMFHIMRLLGKGDSSVQDTMSDMDTVESFSQCSDLAANMLTDEDYLNFMSDTLFSTITNHQPFAFPDCREIARGAGLADFIQPSLGPLQPNLDDFMDTLEPLQDLLSMPRLPPVPEETTIPSEDALYRSGMSVDSYNPQGYIAGSQNTSAVTMPTSQMSIHGTSNNTQLMSMPEQVKGEEMRMYDNSRLFTQTNLPNSIISGQEMHSAFPQSSYERPPAPQPDCAPPLHANAFVAKSPRVQFVATQKISPQPDAYKYNAGIPPSQTAPETVSLLQQPVQNTKYASTIIIQGRSGYSREKPRTRINHYTNQIGNNQYPAYSANITAHSAAQSAHSAGHTVHGTAQATHSAAQAVHSAAQGVHSAAQGVHSAAQGMHSAAQGVHSAAQAVHGATQGYEPRAPAARPPAAQMQYLQLNHVDPYKAKAGPSPTNVRSFKLPSPPLAPAPAHSQVAASGSSSSVPRNKEQFRSHSLPLGAQLSSEWVVSAGGTAEPAAAPGQVLVAPQDASPVRHTPRTRESSGALRLRSRSTSGGLGEPRRVPPPLSSVASEPALPQASVMLAHLLSAHHSQNLYTIKGKDEGAGGSEPTKSPIRRAQPSPIENDVMSPHQSLSPPASPTSPRAGSPRESREARRSHLHTEQKRRYNIKNGFDTLQTLIPHLNTNPTAKISKAAMLQKGAEYIKQLKAERNQIKEEMESLRAQIDCLNNSISNCHSMLPATGAPVSRARAGRLREMFARHVANRTMHNWKYWLFSVVSAALVESFSACVSCGSGADLVRTTLLWAEQHCSLVEMRPAVLNSLRVLCTTTDILTSPERLPEEARAAAAAGAGVKREPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC38</accession>
    <name>A0A194RC38_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC38"/>
    <dbReference type="FunCoup" id="A0A194RC38">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC38"/>
    <dbReference type="KEGG" id="pmac:106710722"/>
    <dbReference type="InParanoid" id="A0A194RC38"/>
    <dbReference type="OMA" id="LPNFWEC"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="49598" checksum="483C46C20C3E149A" modified="2016-10-05" version="1">MRKVNEKAMKSINNYASNDYVDAFSYINERPVDDISLEFFYKPHTITLLAVSIATVIYTAFVRDESTIQDNIWSGTCCVVFFFLIISVLTFPNGPFTRPHPAVWRIVFGASVLYLLALLFLLFQSHSTVNEIMYWIDPNLRNFHIDMDKEYAVNCSDISVAKVWSHVDVFAWGHFLGWMFKAILFRHTGLLWAISIMWEITEIAFAHLLPNFLECWWDSIILDVLICNGFGIWCGLKICKALEMREYKWVSIRDISSTTGKIKRAILQFTPVQWTPVRWLDPNCTYMRFFALSQLVVFWQISELNTFFLKHIFEMPPSHPLVIARLCLIGVIVAPSVRQYYTYVTDSRCKRVGTQCWVYGAIMVTESMLCIKNGKELFGQAQVCNVIVWLVIQILVSIGCVYGVVVYHRYIEPAEDINLETPKKDKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC41</accession>
    <name>A0A194RC41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC41"/>
    <dbReference type="InParanoid" id="A0A194RC41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="107" mass="11718" checksum="DDC66185AC15D44D" modified="2016-10-05" version="1">MRPARPGRRARALACRLAVTTEQRAQVAVGVGVGVGGMLKLHSATDGIIESCRPLSFCPQPRCREDALVLAPHHHYLRMLQNRIPACKTDKTCIKNSVAQKTTCNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCB4</accession>
    <name>A0A194RCB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TP53-regulated inhibitor of apoptosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:36435"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCB4"/>
    <dbReference type="FunCoup" id="A0A194RCB4">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCB4"/>
    <dbReference type="KEGG" id="pmac:106710592"/>
    <dbReference type="InParanoid" id="A0A194RCB4"/>
    <dbReference type="OMA" id="KKYDDCF"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="9325" checksum="85F7FA7CFDACA8E4" modified="2016-10-05" version="1">MNSIGEECTDLKKKYDDCFNSWFSERFLKGDHDDSVCSGIFKVYQDCVKNAMKQQNIDFKEIDKDVLGTDNEFKAPPTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCG0</accession>
    <name>A0A194RCG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCG0"/>
    <dbReference type="FunCoup" id="A0A194RCG0">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCG0"/>
    <dbReference type="KEGG" id="pmac:106710635"/>
    <dbReference type="InParanoid" id="A0A194RCG0"/>
    <dbReference type="OMA" id="GWCEGFN"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07626">
        <property type="entry name" value="BAR_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11763">
        <property type="entry name" value="SH3_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014536">
        <property type="entry name" value="Snx9_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027744">
        <property type="entry name" value="Snx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="214"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR027744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR027744-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="559" mass="63490" checksum="C88FEC191B284AED" modified="2016-10-05" version="1">MTTQVQALYDFTGEPGTTEMSITCGEILTLLNTEIGEGWWEGRNAKGETGLFPAAYVRKLTPDESAPTKMAPAAPRYDQAADEWGDQQYSAGDNNYQRTTSNDDGWDDDWDDDTYSEIGPGGQQQKPSVHPQQQPLTPLPGMPINDYNHRIDDTASNFGSSVGTVRKNKFAPSSKVSGESYLLGTLNVEVPDSDKVHIVQDEDGYIWSPIPQPYSVTVASPKKESKFKGIKSFIAYQLTPSFNNIQVSRRYKHFDWLHERLQEKFSLIPIPPLPDKQISGRYDEQLIERRRVQLQEFVDWMCKHPVLSKSEVWQHFLTCTDEKRWKAGKRQAEKDNLLGLNYCISLTVPEKALLQSQVDHITEQCHTFINSMDTSVKSVSNMCVAQTKRFQGPYKSDCQKIGEAIYNLGNALSLDEGTIVSTSKLTSAIKMTGGAYIEIGRMYEEQPKYDFEPLGDKFHLYKGIVGGFPEVLANHKGAMQKKRECERLTAEHKMEIAQLNEVIRRSDVISYAVLAEINHFKSERTIDLKATMQKFLTQQINFYKRVVDKLENTLQQYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCV5</accession>
    <name>A0A194RCV5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCV5"/>
    <dbReference type="InParanoid" id="A0A194RCV5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443741" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="137"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="342"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="523" mass="58692" checksum="5C9FE6147864F3D6" modified="2016-10-05" version="1">MLKWIIFLALILVAIGESKEVRQLNIAQGPVRGYKDAGDDVFVFYGIPYATAPTGPNKYKAPLPPPTWTVPFEAINKNIICPQMKYRFVTIPNSTQSEDCLIANIYVPDTKTNNKDYNKSYKLIKQSPKPQPIQILAPLPPPTWTAPFEATNKKIICPQTEDLFMPYPNSTQSEDCLIANIYVPDTKTKKLPVLVYVHGGAYQIGYGEFAVAKNLIREKEMIIVNFNYRLGPHGFLCLGTPDVPGNAGMKDQVALLRWVKKNIASFGGNPDDVTIIGYSAGSSAVDLLMLSPMTKGLFSKVIPESGSNMAVFSVQGNPVETAKAYAKFINFTGDQDDVYALERFYLAIDQLDEETNILDNIDYFTDVMFAYPTLRSVRLQVESGNNNFYLYQYDYVDDSAPLIPYTEIRGANHCAQTFGVIDGAWPNLTEDELSKDTKKMKQVMRKIWATFITTGKPVSENSDLPQWPPTRANGGPHMCIDKSLKLRGPLIQQRVLFWDEIYDKYYKIPTPPPSPPPSQKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD51</accession>
    <name>A0A194RD51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Krueppel-like factor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD51"/>
    <dbReference type="InParanoid" id="A0A194RD51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="327" mass="35924" checksum="384A409C60F73B57" modified="2016-10-05" version="1">MSVIGRPSRCPALVAADAGLAALCSAAAIQAHALQSHVLVSEMYREELIFEDAALDDQLLFEYSPAESLINFELPTSVTADVDDWQISDLEFNCDAFLGSVCERTRDGSEDDSPVLFDFADLDKNVNFDDYLLEALSCDRSEDRLQLGSDSVDGCDDPALGALSVLGIDLESICGESSQTAAASMNEASEKECYPTETVPKSRSWGEPTFCPELGAFRCPVGECGKLYAKASHVRAHLRRHSGEKPYKCTWGGCSWRFARSDELARHRRSHSGDKPYRCAECSKRFARSDHLAKHGRVHARRAAASASAALAKRSSPTHAYRTRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD99</accession>
    <name>A0A194RD99_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap1 GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD99"/>
    <dbReference type="InParanoid" id="A0A194RD99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="69"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="438" mass="47881" checksum="982049233B39F3B3" modified="2016-10-05" version="1">MSLKNEHMAGQDHTRILLRLRTETMHGLIPVTTRSGIIPSPARMAKMLNEQVNVDNFMAVTCLSASPLIATYDEHVLVNNFKFGVLYQKFGQTTEEELFGNNETSPVFDEFLEMLGQRIKLKDHKGYRGGLDIQNGHTGSEAVYERYEERQIMFHVAPLLPHTAGDAQQLQRKRHVGNDIVALVFQEKATPFTPDMIASHFLHAFIVVTPLESNGGETRYKVAVTAREDVPFFGPTLPQPSVFRKGREFKEFLLTKLINAENACYKAAKFAQLELRTRASLLQNLAEDLKSKTIEFLGAGVRSEPVAVSPQPEGFGTPKLDGPGARFIETVKKAIYKGRSPSDPSGDSTKGSLNKKINIHDTPTPNSGRSKTSIASSSASAVSVRSAGGSGGSSPDVTSRAAPPRPHHDHSDDSSLNSVDLDPLDDKDWLSCGKGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDD3</accession>
    <name>A0A194RDD3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDD3"/>
    <dbReference type="InParanoid" id="A0A194RDD3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9025" checksum="F89E115BA310E973" modified="2016-10-05" version="1">MSTLHSSHGNISDLTLIPGKIIETAKQIFGLQNSNEQTSRAITPVTTKPAPEDNKMLAALKSHPEGVQNSVQKVADVQGDVNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RET3</accession>
    <name>A0A194RET3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pleiotropic regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT. Also interacts directly in the complex with BCAS2 and PRPF19. Interacts with USB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RET3"/>
    <dbReference type="FunCoup" id="A0A194RET3">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RET3"/>
    <dbReference type="InParanoid" id="A0A194RET3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="424" mass="46481" checksum="4F4E3F03A100E9AE" modified="2016-10-05" version="1">MADDVIKHSVHTLVFRSLKRSHDMFLSNQSLLPPIDEKAEKILKNVKARDSYSQVMSAVEQAQAVKQQQMLSRPETPHDTEMAESAALGSDGAMLPYNPGSMSAPAAPGSQGLLGTGAAAVVPRRPPTVPKPKWHAPWKLFRVISGHLGWVRCVAVEPGNEWFATGAADRVIKIWDLATGKLKVSLTGHVIRHYHGHLSAVYALGLHPTIDVLVSAGRDATARVWDVRTKANVHTLTGHTDTVAALACQSAEPQIITGSHDSTIRLWDLAAGKSMCTLTNHKKSVRSVVIHPTQYTFASASPDNIKQWKCPEGKFIQNLSGHNAIVNCMAVNSEGVLVSGGDNGTMFLWDWRTGYNFQRLQAPVQPGSMDSEAGIFSMTFDQSGSRLITTEADKTIKIYKEDDTASEETHPVNWRPEILKRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGH0</accession>
    <name>A0A194RGH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGH0"/>
    <dbReference type="InParanoid" id="A0A194RGH0"/>
    <dbReference type="OMA" id="QRECACY"/>
    <dbReference type="OrthoDB" id="7087888at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="13949" checksum="33EF46E4E90FD77C" modified="2016-10-05" version="1">MSVLPRGYESFRPCPRYGCVQGSPGIYYKRPRCGQPRPQPYQREVAPYCSGPSNAPRDRPCCYDFPCKAHCFNHGACTRPSGRYARTVWYPGECCPRVPPCQAFTCPNPPYHPCCTYTCNKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGU1</accession>
    <name>A0A194RGU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RGU1">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGU1"/>
    <dbReference type="InParanoid" id="A0A194RGU1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2051"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2116"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2193"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2255"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2052"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2071"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2081"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2142"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2160"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2256"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2286"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2302"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2317"/>
            <end position="2327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2341" mass="267056" checksum="8C6E47EE5FFD7A1B" modified="2016-10-05" version="1">MHHLYPLAKGDPLCPLGFHPQVRWPTRCKRCFRDYKEHGGGGGSGGRRRDDDFASTPSLATWTSPVGAARGRDEETSGEKTGRGWASSTNLSSIDTPKKDTLSTGGNKTSTWTSTPDLANDSDTTTAVTFSLKLPKRRNTGPLPSIDTGQNVTDTVLVRRPSPSPPPTAAATITINKNDSLAERVRKMQLIKSQNSFEKESSIEKEREKRSASRSKEEEKTVKLKEERASAKDDVNFLIQVKNSRNTSSNSKPPIRGGPARDKEDTSDDETSTAGTITTDTTLVDANIKDYQDQIENLKQEVDLLRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTQNEDLRDEKKHLALRVREIEAELESRPSIEAQTKQIEQLRSKLLAAETLCEELMDENEDMKKELRELEEEIEEMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAEQLEIEKAEQEKKLLEIVGGQDGMQRENRIKELEQEVARSTEVSLRLQRDLADANAKLAAVSGAPPANLKKHTPPSDGKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEEASRYRHRYAGRRIPHLPNSPQLAFTSKSQTNSVEDKSRQQIIETQIALDKKLSSFDLRKLTIGVNEIAQSPQDHIQYYSQGCQTDHVLLLDIGTEITKITLDSNVQCTISNSEMYTQTEIPFTKNKVAQTDILQRNCLTQTDKAKERVAATQTAPQMKNDISTQIENYIIESIDVSTNTKGLVVIDKSVSTESCAPNVSCSDDTDSMKNNNEILDRRKEKSDSPPLSSDKTVPGPSDRIFPFVSLFNPLAARIPIANNLRKTASRVEDDNESLLLQLKKMATKARSRKLSPTPPSNRLSIEAPNEKDEGISDEEDPAELRLLLELNEQESAVLRRKVEDLEQERDSLKKQVKELTEKISSISSKQNNTTTTGIRRTTGKSNNLAEEKVKVLEDEIAELRKKLIEKDRDCERLHAELSIAQKKPKASLIKSKSLDGGNDLQNVDLKRQLQVIEQEANVLRAKTQSLEADNEKLQSENKKLQLMKNAKSIKSDKNLEQSSIKVTQLETELKEALAKIRDLESSKEKDEKTEKKVRFGSDLNKKDAETLKLKQEELDKLKLNYTKMEKEKAKLQLTLKELKEDAIKSFKPRSPKKLTDLTTKLQMKKMVDDLENEIGELYVIMKNAGLSSQEINAKAQLEKDIEEIRSKLSRNESEFKNEKNRLQTEIGKLKDINSKLESEKVSFTDKCKGLEVENQKVLSECKTLKEEKKNLESQISKLSADLKKTSTYQTAMSDCMKKIEDLKKEMDTKDKEIDKLKKQVDSINKLEQDKNKLLKEVGDKTKKITELEKKLKETEEKCKRNEKLLSSQKDRVSKLQKELTEEKQQAEALINSHRRSSIEFTSEKDELQTKLIKSESKVINLETDIRDLKKEYDKKIIDLESTIAAKDTHIKQLEDALRETSHQKYDEPVLSSELSQMKEKYETATKEIQDKEEELLSAKQKLNTIEKELSILQTETTQLKSEIAKHENERKDLENKLQTEKKESKYWENKTSELESDLQAKLEHSLAMEKAEYEELTVKYELLEEEHVVTKARLTVEKEQAQGELLHVRKELNATLSDLKSLQEKMETQVSNLNKEKSELQNEISSLQERLCGGGWEVERARLQARLEQRERELRDAHDQRDVLAHHQDITKKELEEARKKLEDYEKVSKVHRNLSADNVELERELAAMNGRLEQAERARKAELADTKIRYEGQMTTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKTMEELKSGEKRTHRASISSTDEEEYRNKVAVLEQQMACLEDELCEARLLSSKLNTELVSERSQAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTLFEVERERDKERLDMKRRIEQLKRTTEEEIEEAKKKVTELQCDLLELRDAHAKLRTASEKLRRDKERHERDRDQNKLLVASLKRAQQEDDRVITQLLETIDDLMKQSPELFRNEQPVKPEKSLMTPTPPRRNRSSKSRSRSGTPESAEVASAASAAATAARLRRLTDELRASRIAERTRRHQAAGMRRGMTAEPRDAMSVSPATRTPSRASSLKKRSISLEQTTKEQSTIWMSVEEGSVSSMQSLDGEDSRLYTLPRDSSLDSRLSGGSAQSDVLPTEKKKKKSIFGKLKKLTKSRSVDDHVENAEVVDFRPIGTVSQGSDSDMSTAGSKRDLRGRISDMFSRKGQISRTSSSKEQSPERASSSASTGSARPILRNASTNALTRQSPAKPVTHPVLMLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIA1</accession>
    <name>A0A194RIA1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein Nova-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_13911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIA1"/>
    <dbReference type="STRING" id="76193.A0A194RIA1"/>
    <dbReference type="InParanoid" id="A0A194RIA1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="16395" checksum="F3590B9A42061CD1" modified="2016-10-05" version="1">MSVEGYTGWPRQRWMDCVRKGLTMVMTADRLIWRTETWCTAPPVEPTYHFKVLVPSMVAGAIIGKGGETIAQLQKDTGARVKMSKSHDFYPGHCNDCFSKLAVDLNYSRELLRARWRIWTGHALTHLCQDLAHQPTQEALCSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIA5</accession>
    <name>A0A194RIA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thyroid adenoma-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIA5"/>
    <dbReference type="STRING" id="76193.A0A194RIA5"/>
    <dbReference type="InParanoid" id="A0A194RIA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="1">
        <location>
            <begin position="749"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126296" checksum="9FC76DA3CD58CA93" modified="2016-10-05" version="1">MKGNLAFNPVVIPPHLINKIVDGHTLFEKFNQSNSVDEQLLILRENLNNHCNEKTLHFLVLIFLQTEIKHPIKCFVVRYITKNDHLQEPFSKALAEEISKHFSVDNIEYKVYNDFIPKLASCIENFPSGAQAIKLVEARLTAYLIQCLCCCVHTLSSKKTLSPTEKNEIFDLTHLTLRLLLHIVQKIGNKNCTELMSHFNAIKLNIKELLFDDDVPMDSKSVCGILFLTMYILENGLKSWCEVLNPSGNNQEFSELLCNNSARLSLHSALATVISAEDLCTTTIGDQHALLLLTDNILAIGEKMSSDSTFTLGVTRTLVQISRTLLKCQSQLGLRLVDSLLVFVWAHLEHYMDSVRHLTAQVLGHIVKYCTHLKDKGEEKALEKLLTAILSLDKSRKSYYVSVRCLSEELGAGHVLSRLPAALRDLLAALDLQTVQACMVPSERLDLDDGLDYICRTQSGKLLFDDDVPMDSKSVCGILFLTMYILENGLKSWCEILNPSGNNQEFSELLCNDSARLSLHSALATVISAEDLCTTTIGDQHALLLLTDNILAIGENRKSYYVSVRCLSEELGAGHVLSRLPAALRDLLAALDLQTVQACATSALESLLQRHSRECSSAEMYHIWVQPVLTHLTHNHLHSSVLNILENLLLQAVKLDRNILDYLLPHIKELPTSNENGREDLKCVLMLLSVVRKSNAVGKMMEKEGEWKGLIGYDVLKMAAVNAVDEATSALESLLQRHSRECSSAEMYHIWVQPVLTHLSHNHLHSSVLNILENLLLQAVKLDDNILDYLLPHIKELPTSNENGREDLKCVLMLLSVVRKSNAVGKVMEKEGEWKGLIGYDVLKMAAVNAVDETRILTLSLVVESPKSTESFSVEELYLVLWYLRYNINAQAPNLRQLTLSLMKKFMKRLEDSYKVLKRQNAPNGDSNKSDYYLTFLEDMREFCYKCLVTGANYSRRYVALQLLDWTETTGYEGYHRTWKSEYIDNLLQCLDDSYESNKVFALEILQTCPQDLLESQRIVAGMDMESILSQTSSMKPPDCVSAAYKLRLFVARFPHILLQGYDTDVPECVRHAALRRLLHALAGEVRACERSVVRAARHAHMYGALHCMLHILQHVDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL46</accession>
    <name>A0A194RL46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">F-box only protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL46"/>
    <dbReference type="FunCoup" id="A0A194RL46">
        <property type="interactions" value="1496"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL46"/>
    <dbReference type="InParanoid" id="A0A194RL46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22091">
        <property type="entry name" value="F-box_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000003">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000005">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000087">
        <property type="entry name" value="GG17321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047505">
        <property type="entry name" value="F-box_FBXO11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="10">
        <location>
            <begin position="797"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="7">
        <location>
            <begin position="797"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="97217" checksum="16B7D856C7DFA407" modified="2016-10-05" version="1" fragment="single">AAATPAGHHSPYDLRRKSPPAYHEPGPSGSCSLPARKRPRTSLSQGVDVCNVSQYLQYELPDEVLLCILSHLTERDLCRVAQVCKRFNTIANDTELWKSLYQSVFEYDTPLMHPAPCQFEFVAPDECDADNPWKESFRQLYYGIHVRPNYRPKKDSRIKHFNTIRAALEYVEERSGVSCASGGSCSCGGSGGGGGSAASGGGGAAGVCSCRRTPAPPPALLFVHAGLYQEECLAIDTDVQLIGCAAGNVAESVVLEREAESTLTFAEGANRAYAGYMTLKFSPDATSTMQHHKHYCLEVSDNCSPTVDQCIIRSASVVGAAVCVSGAGANPVIRHCDISDCENVGLYVTDYAQGAYQDNEISRNALAGIWVKNFANPIMRRNHIHHGRDVGIFTFENGLGYFEANDIHNNRIAGFEVKAGANPTVVHCEIHHGQTGGIYVHESGLGQFIDNKIHSNNFAGVWITSNSNPTIRRNEIYNGHQGGVYIFGEGRGLIEHNNIYGNALAGIQIRTNSDPIVRHNKIHHGQHGGIYVHEKGQGLIEENEVYANTLAGVWITTGSTPVLRRNRIHSGKQSRQCETRRVFVVASRSVLFSDSYDVPSSCGEVGVYFYDNGHGKLEDNDIFNHLYSGVQIRTGSNPVIRGNKIWGGQNGGVLVYNGGLGLLEQNEIFDNAMAGVWIKTDSNPTLKRNKIFDGRDGGICIFNGGKGVLEENDIFRNAQAGVLISTQSHPVLRRNRIFDGLAAGVEITNNATATLEHNQIFNNRFGGLCLASGVSPLVRGNKIFSNQDAVEKAVGGGQCLYKISSYTSFPMHDFYRCQTCNTTDRNAICVNCIKTCHSGHDVEFIRHDRFFCDCGAGTLSNQCQLQGEPTQDTDTLYDSAAPMESHTLMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM60</accession>
    <name>A0A194RM60_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM60"/>
    <dbReference type="FunCoup" id="A0A194RM60">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM60"/>
    <dbReference type="InParanoid" id="A0A194RM60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265305" evidence="2">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="117"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="33396" checksum="C1B5723419C33DD1" modified="2016-10-05" version="1">MDHHLLLFLSRQPLLLRGLPILTNQFDVDEETIDTIENEEEPDIPNVDESESLLSNVVSDVNKTLTNLYNHVTSANVTAENRTNTANETRKLVKCKEILYEGTEEIEVEIINGTHLAKLLQVKPDITSRDTEADCVLVLFYARACPFSAHAAPHFNALARSYPNIKMVALDALKYHGINAQYGIVGVPTLKMFHNGRPVGKFNGTEYNIQSFSKFVHAITGQYPLELLVTSKDFQGPVSSVVEKDTDYFLVLSWLFIIVCSIYYFMQSKWWNMIVEMVQNNWRESEAQHEHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN86</accession>
    <name>A0A194RN86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN86"/>
    <dbReference type="FunCoup" id="A0A194RN86">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RN86"/>
    <dbReference type="KEGG" id="pmac:106720681"/>
    <dbReference type="InParanoid" id="A0A194RN86"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF2">
        <property type="entry name" value="GH08893P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265320" evidence="2">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="125"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="35441" checksum="4FF962F5C179DD20" modified="2016-10-05" version="1">MGLKFLFVLFMCTWLVNADLQNVSDEELLSLIKEKEKLIVLFSKANCPLCDKFDQQLESLNVDFKKHLDALTVKTENSHLVRLYSPSKEPAVVFFRHGVPLLYSGEPDENEIYGFFEKNQSPAVKELTDKIFEHMTQAATGATTGDWFVMFYGASCVECQRLHAVWESVGATLRNRINVARIDANLPGVNTAKRFKISKLPSFLLFRLGKVYRYDLPKNDVKSFVSFAQDWYKNSKAEIVPLLASPFDEVVDWSVDMLKFSIAYGLDILIKYPWIWQIGLAGFGLVAITALIALVKARKPKPKGVKKDKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNT0</accession>
    <name>A0A194RNT0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rabenosyn-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNT0"/>
    <dbReference type="FunCoup" id="A0A194RNT0">
        <property type="interactions" value="1578"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNT0"/>
    <dbReference type="KEGG" id="pmac:106720671"/>
    <dbReference type="InParanoid" id="A0A194RNT0"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15716">
        <property type="entry name" value="FYVE_RBNS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="440" mass="50816" checksum="878FE73DB9743200" modified="2016-10-05" version="1">MAAANEDEILEGFLCPICKADLKSATQLTNHFESLHQEEQDVLKSLKEIFGKAKKIILNNDETELKETFDRALKFNSQEYYYPNEEQSLGVSRSSTDYFRGVRSARLERYATETNKLLIRLDKLVCNMPSEPNQRKAFEQEVVPWLDGSSVKLCPNCAKAFNLTRRKHHCRLCGSLLCHDCSVFLDLTVAKSIVDPSIPQTSTQPDQEVTEKNGLRLCEHCYNLIELRKQIQERRNAKTAFVTAYEQMRSLMDQARPAVAMYEKMCQSLFDGETTYNLADVNAMRGKIGKLAEGIDLLSKQIVAHPAEPGTRQARLQNSIRQAAAHYIKEDLLSLRKLPTEGQIEEVRRERYERAQKQIQLERERRERERDWREEAAGSGSRVEHADVDENNPLIEQMNIIRGYIKDARKELRFEEVAILETNLKELKKEYQLQMLSNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR91</accession>
    <name>A0A194RR91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Glutamate receptor, ionotropic kainate 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_07424</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR91"/>
    <dbReference type="InParanoid" id="A0A194RR91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000178">
        <property type="entry name" value="Glutamate receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="379"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="17">
        <location>
            <begin position="389"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="808" mass="93477" checksum="4EA1EBDE6A6BC214" modified="2016-10-05" version="1">MLLAGIFEEEAITQRLAFDDSMKDASLDDYRLEPIIIPRSRPDIYTTWRDVCSNKMMQPIAIVGPQSPFKNTAVLDQCFISKIPYLQATWQPPEIEYIFENDSTIVDNSTETEMHEDAVEYKKIIINFYPDRLIRIQKILAEYTDQYPVTIRKLEPDGDNYKVFKELQNSQETRFFIDCHVDNVLKYMDIINMLNLDDFYQHYIFASLDTSIVAHKLTDYRCNITWLSITDYDKLIDAQHFLAQRVERWAINTVSPPVTDMPIEALLINDVANHVVKALKTVEKTTSIQKPPTFSCDSEDIWEHGGLMQQEILKTKTTGVSGNIEFNEMGKRTNYLLHVNEIYLRKRQTIGNWESSSGENIIEDRPDADNIVNQQTRKHFYVISRKAKPYFYEKEKCTTLECEEEDDGERYEGFSVDLVKQIFETLKKENFNYTYSFKYDTDYIYGQYDKEKKKWNGLIGDLLDKKADLAVCDLTITEERKKVVDFSVPFMSLGISILYVQEKKVDPGMFSFLNPYTFEVWMYIATAYCVVSIVLFVCSRISPADWENPQPCDKDPEELENIWNFKNCAWLTMGSIMTQGCDILPKAIGTRWVCSMWWFFAVIVCQTYIAQLSASMTSALENEPINSVEDLATQNKILYGAIDGGSTLGFFKNSKDKMYQRMYENMNANKVVLVNNNDEGEKRVINGKGKYAFFMESQEEDKNDVEGDLEIKNLIGAFLVLIGGLVLALFITAAEFMNEVRNIVVRERVTHKEVFIKELKASLNFFQLQKPVLRNPSRAPSAASSFQTVNKERANGIDNFLDLEREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRN1</accession>
    <name>A0A194RRN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium channel KOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRN1"/>
    <dbReference type="STRING" id="76193.A0A194RRN1"/>
    <dbReference type="InParanoid" id="A0A194RRN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="23005" checksum="987F5F367009F09A" modified="2016-10-05" version="1" fragment="single">QVKRAVALIHEDKEFLIAAEIGNYKMLEILIRQGVDIQQMDHLGRNALHLAVCADSMDTIVLLLNAGVKTNVKDNLGMTPLSLSLMRRPSLEVAHLLFDHGAKIIPRLKPMDTGLFLQFVMMCTPTDEETKILALLIDKGALINDPEAPGGRQALHFAAMSDNCPLIQILINLGADLFLINHRNQTPIDVALSFKCKNAYTFLSKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS66</accession>
    <name>A0A194RS66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein roadkill</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RS66"/>
    <dbReference type="STRING" id="76193.A0A194RS66"/>
    <dbReference type="InParanoid" id="A0A194RS66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="376" mass="42543" checksum="D5C1E1414EC7DC16" modified="2016-10-05" version="1">MAVSRVPSPLHDGNTPVAENWCFTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGASDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSINISGQSNVVQFKVPECRLSDDLGALFDNERFSDVTLAVGGREFQAHKAILAARSPVFAAMFEHEMEERKRNRVDITDVDHEVLREMLRFIYTDRAPNLDKMADDLLAAADKYALDRLKVMCEEALCLSLSVETAADTLILADLHSADQLKAQTIDFINTSHATDVMDTAGWKNMISSHPHLIAEAFRALATQQQQIPPIGPPRKRVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS82</accession>
    <name>A0A194RS82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RS82"/>
    <dbReference type="InParanoid" id="A0A194RS82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="541" mass="64026" checksum="87C850C31CD412A7" modified="2016-10-05" version="1">MFSNNNVSLRRLLRKVRIYWPESINRDFKRAYLKHLNQSDGQNAITHGLCILLPKEELTMILNKHAPVDPKVDWDNIDELELGLQRCLAKNMHNARPHPHLETVLSYAKGDYLTYALSSVLAVYYNMSSIQYQEFVFQILNTPVSLQKHGLRLLFNKLSSEKIRESCSALWKETKNSTIRTEIFKIIYKLLCNEKNESNITQTWGLLEMLINDLTFLEDKSIYKLLYKVGQIPQSVKAKFLVKSYNYLKTLIENNQKEYEASEWDVRNLVMYSTKIIESMPYEFMTGIIEDYINNEFFKERIYPGDKTKLISSFILCSTTEEEQMKKYDEVLAPILIRSIKLWNDQINPKYYIKLNTEQLLFDLIHDLENYTDGKKMIVPVKMFRIIQKTLEQSLPLSENYILIRTWQLATNLVTLFDKNQPIIWEDTCKKIVPEFQKICKDYLTEDTKSFFPRIYILFMNAFANVSRVFSEDIKYEICKSFVEKEDFLAGYLAALQFIRLLSDEKNIKDIRENIRKHPSVEVKMHYYNMFQEDQAALFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAK9</accession>
    <name>A0A0N0PAK9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAK9"/>
    <dbReference type="FunCoup" id="A0A0N0PAK9">
        <property type="interactions" value="2034"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAK9"/>
    <dbReference type="InParanoid" id="A0A0N0PAK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000060">
        <property type="entry name" value="ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="28984" checksum="E34C9257818D030B" modified="2015-12-09" version="1">MCDINDNPIKLSVKWNGKEFDIPELSPSDSVAMLKIAIENATGVRPERQKLLNVKYEGKVAKDNCTLADLNLKPNLKIMMMGSLEQAIEGARTKPDVGDDVVNDLDIEEEEVDVENQEIYLAKINKRVRDYKINVLNEPRPGKKLLVLDIDYTLFDHRSVAETGYELMRPFLHEFLTSAYEDYDIVIWSATGMKWIEEKMRLLGVSTHQEYKIMFYLDYLAMITVHTTKYGTIDVSFLNFSYSMVVMVLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBL2</accession>
    <name>A0A0N0PBL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBL2"/>
    <dbReference type="FunCoup" id="A0A0N0PBL2">
        <property type="interactions" value="1840"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBL2"/>
    <dbReference type="KEGG" id="pmac:106715132"/>
    <dbReference type="InParanoid" id="A0A0N0PBL2"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="231" mass="25833" checksum="4DEBFE84FD452254" modified="2015-12-09" version="1">MEWLFGHRLTPEEMLRKNQRALNKAMRDLDRERLKMEQQEKKVIADIKKLAKDGQMDAVKIMAKDLVRTRRYVRKFMLMKANIQAVALKIQTLKSQSTMAQAMRGVTRAMATMNRQLNMPQIQRILQEFEKQSEIMDMKEEMMNDSIDDAMEADDDEDESDAVVAQIMDELGLQVNDQLSGLPQATGSLSVASKQPSAVAAGGGCAGGAGGAPMSDADAELQARLDNLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBW9</accession>
    <name>A0A0N0PBW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carboxypeptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460778">
        <property type="protein sequence ID" value="KPJ12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBW9"/>
    <dbReference type="InParanoid" id="A0A0N0PBW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="140"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="505" mass="57902" checksum="70C0CC7D18A3A2BB" modified="2015-12-09" version="1">MKLNSTEQEDNLHKIKNDFIDYWRKPSFKYNNIGQAMVPPAQTTWFEERLGELGVPKDIYIDDVYNVEERESTVVDPATTIFVGCTNGPGRPVKYNDHTEERRVVCTTHTHRLMSVRSGYLSPSQRPATHLRFVWYCRCSWASMNTLMFPLLILDYIRTLEETYKNSTDITLNVIEAGTTAEGRPLTYIKLTNQTQTVNKGIIIIEAGINPRQWITIPSSLNIVNKLINNNDTRYLNDFEWIVIPVLNPDGYEYTHTNAMVPPAQTTWFEERLVELGVPKDIYIDDVYKYLLLREETSLDMSRNGDNNTFTFNDYYRYSQLRLWMKSRSTRSNLGAICPGVNINRNFNIDWLNSDSSSSPCSHLYGGIGAFSEVESRIVQSLFEEYGNRIRAYISLQNNGGFISYPWQYERAASGLFAQHHILGMKMIAAMEDSYELDIASVAYGDRASGTSTDYMRSRGVLYTFNIDVVPRGQDGVIVPREEIQTIADDVWRAVSVVAENLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDC0</accession>
    <name>A0A0N0PDC0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDC0"/>
    <dbReference type="InParanoid" id="A0A0N0PDC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="21998" checksum="B49BCB29062EECDB" modified="2015-12-09" version="1">MSLLMFKRNLSYCQPNKTGVLSLDNMTPFVTIKTLYATNWETYIFKDKEYLIQNLPVNWENAKILCQGHHNGNLATLDTKEKADFLAEALSESQLDVDAVWVGARRGSSEDPEGYRWSRGSELRRTSADILKNEKDENAVRHYPLWLNRTHVPVPEGGADCVALERVQHDKPVFLDLSCQLERPFVCERGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDR9</accession>
    <name>A0A0N0PDR9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDR9"/>
    <dbReference type="STRING" id="76193.A0A0N0PDR9"/>
    <dbReference type="InParanoid" id="A0A0N0PDR9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="599" mass="67023" checksum="56530F769664A82E" modified="2015-12-09" version="1">MLPQTKQTMDAPTVPTIRRIQIALQLLASLKLFSYLFPQQAVVYDYSTYDYVIVGGGTAGSVLANRLSEDRTLNVLLLEAGDDPSLEVLLAGLVHLTARSRLDWNYTSETTQYSQCHKGRVLHHPSGKVLGGSSSINYMLYSRGSPLDYDMWATVVNDSAWNWYNTMPYFLKSERLEDPIIYNSPYRDSHGINGYLGVTRETSSELRKYLDSFRENGKLETFDVNGNESMGYTPQMYTIAGGARQTTAFSYLTPIRNRTNLHVMKNTMATKIIFDNNNHAIGVEALTEHNETYVLKASREVIVAAGAFNTPQLLMLSGIGPEEHLRLLNINVRSDLPVGYNLQDHPFVLLSIRGERSATATPHSDPHNFPLPTFTGYVALNRAQLHPDYQSINFAVPSDSPMPQKFCSLNFGFKSDICQILKAGVKGRKTILSLISLLHPKSRGRVMLRSTSPRDPPLIYSGLFSDESDIEDLISYVKDFTSVMNTTYFRDIRAQLVDLSGNRCMGYKLWSREFWRCYVACLAAPLHDYTGTCAMGLVTDTRLRVRGVRRLRVVDASALPGLVGGNVLAAVVMLAEKAADLIKRDLSLNFRPSHPFINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFC3</accession>
    <name>A0A0N0PFC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01019880">
        <property type="protein sequence ID" value="KPJ21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFC3"/>
    <dbReference type="InParanoid" id="A0A0N0PFC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="11995" checksum="0A622FA5BC8FE09F" modified="2015-12-09" version="1">MSMGSRRFAISANSCGRLLELERLARVHGLPLGGEGWTGDDGEGGETGVGAVGGDTTPAPAHNTPKTPSTPEVVLPKREPAAMDVGDAPDLLRDMPPPDCLPPLDALGNYALCCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG12</accession>
    <name>A0A0N0PG12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-sulfolactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050572">
        <property type="protein sequence ID" value="KPJ21492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG12"/>
    <dbReference type="STRING" id="76193.A0A0N0PG12"/>
    <dbReference type="InParanoid" id="A0A0N0PG12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="19001" checksum="BF3848CA86A2B606" modified="2015-12-09" version="1">MATTAVAVGKIEMQLRKGESIPKGWAQGPDGKETTDAALAYETQCLMPLGGAENTSGYKGFGLSAMVELFCGILSGSLYGHHIRSWSHSGEGGAADLGQCFVALDPGCFAPGFQHRLADCMQHWRQLQPVLYFVTIQRLLGEYLSFYCYCYFIAVRKKILNLNLKVQKISHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6U7</accession>
    <name>A0A0N1I6U7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460689">
        <property type="protein sequence ID" value="KPJ12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6U7"/>
    <dbReference type="FunCoup" id="A0A0N1I6U7">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I6U7"/>
    <dbReference type="InParanoid" id="A0A0N1I6U7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF112">
        <property type="entry name" value="PROTEIN WNT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="43877" checksum="B8D5DEBA3CF93DAF" modified="2015-12-09" version="1">MTADRDLWKSKRKSQNIVKLMFYCRSSESGGVSLGAHLVCARVAGLTDKQRAMCRSSPAAIAAVGDGLRMAYAECREQLSGYRWNCSGVGDGNDFGHVMPLATREAAFTYAITSAGVTHALSAACARGDLPACHCNSNRRRMTGPSEQFQWGGCGEAAYGARFARRFLDARELESDARSLMNLHNNRVGRKYSCGEAAYGARFARRFLDARELESDARSLMNLHNNRVGRKIVKDLVRRECKCHGVSGSCALRTCWRALPPFRTVAAALRERYHRAKMVTLHPPPDTNAPHSHLVIRRARQNAGVGRQPRKSELVFLEPSPSYCEPDTAAGSFGTHGRHCNRTSRGENGCETLCCGRGYNTIRTVEETKCRCQFHWCCRVTCDKCITRTETHVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I704</accession>
    <name>A0A0N1I704_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I704"/>
    <dbReference type="InParanoid" id="A0A0N1I704"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="30369" checksum="43532D143E737991" modified="2015-12-09" version="1">MDSKAGPSKSKIKPTFFTSQTKNKTRHRDDLDSEGSGEYIDEDIYSQGAHEEFSSSSEGFGSDSDLSIFNVRQKTKTTCPPKKTSLRPRADDTPAQPSRSSASKRGLSESNHSPIIQCKRLKPMNRDGPTTRLKKPGTCVTSAQSSKLPSTSSPSKPAPRQLELDGSGIFEFNYEFDCRATSPSIVQDCGDLFPDITERHDASLSALPEPLSNSSTPSNLPDDDDDVCVCRWRGGRAGGAAGGRVAAAAVRGAASPPPGSFAGEPQYPDVGASLEWREVLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7M1</accession>
    <name>A0A0N1I7M1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460968">
        <property type="protein sequence ID" value="KPJ10239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7M1"/>
    <dbReference type="FunCoup" id="A0A0N1I7M1">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I7M1"/>
    <dbReference type="InParanoid" id="A0A0N1I7M1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000139">
        <property type="entry name" value="ras-related protein Rab-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="241" mass="26929" checksum="50F0DB4A3CF21AFC" modified="2015-12-09" version="1">MSASGEFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVSTEDGDRKARELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSAENKPPEDSILFYHTTARSDSAPGSRRQQGARQRLRLLAPGTPPSALRPPPSALLLLSAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8C4</accession>
    <name>A0A0N1I8C4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460796">
        <property type="protein sequence ID" value="KPJ12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8C4"/>
    <dbReference type="STRING" id="76193.A0A0N1I8C4"/>
    <dbReference type="InParanoid" id="A0A0N1I8C4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="222"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="493"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="583" mass="63329" checksum="C047764D254722E8" modified="2015-12-09" version="1">MDEETSNLVNNFDLNDDLNIKNSVDNENSDVSCASDVIHEFIDERNVEFLKETLNTEEVPSDVSTNGKIENNEVFSDVTSHDDSDAITMEGNRKGWRKPKSRTVMPAGGGGAGGVAVGGAGAGGAGGGRSPRSLASHDAANEDALHAVKDKDGKKKTKNKEESSALSSLPAPSFTSLQPFNLTSSNTHGHDKRQLGCLPVARAQWGCEGPYSGVYAAPAAVFRLAFLGSVEVDEDSRRRKKRPKKNMVEEAVTKIKAPEGENQPSTEVDLFISTEKIMVLNTELKEIMMDHALRTISYIADIGDLVVLMARRRFVPHENDSDQPKLNRTPKMICHVFESEEAQFIAQSIGQAFQVAYMEFLKANGIEDHSFVKEMDYQEVLNSQEIFGDELQMFAKKELQKEVVVPKAKGEILGVVVVESGWGSMLPTVVIANLAPAGAAARCGQLNIGDQIIAINGVSLVGLPLSTCQTYIKNSKNQTVVKLTVVPCAPVVEVKIKRPDTKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINAQSVVAVPHERIVNLLATSVGEILMKTMPTSMFRLLTGQENPVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I987</accession>
    <name>A0A0N1I987_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tyrosinase</fullName>
            <ecNumber evidence="4">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_03909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I987"/>
    <dbReference type="FunCoup" id="A0A0N1I987">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I987"/>
    <dbReference type="InParanoid" id="A0A0N1I987"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000004">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.10:FF:000001">
        <property type="entry name" value="Phenoloxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="714" mass="81673" checksum="A01B9E59F24B196E" modified="2015-12-09" version="1">MNDSKKNLLLFFDRPTEPCFMQKGEEKAVFDIPDHFYPEKYKALSSTLSNRFGNDARRTIPVRNIALPNLDLPMELSYNDQFSLFVPKHRQMAGKLIDIFLGMRNVDDLISVCSFCQLRINPYMFNYCLSVALLHRPDTKGLNIPTITETFPDKFMDPKVFRRAREVSTVVTSGPRLPVVLPQNYTASDTEPEQRLAYFREDIGINLHHWHWHLVYPFESSDRAIVAKDRRGELLYYMHQQIIARYNIERFCNKLPRVVPFGTDLRERITEAYFPKLDSQVASRAWPPRFQGSALQDLDRPVDQIKIDVSEMEMWKARILEAIESNSILLPNGRQMPLDEEKGIDIFGDLMEASILSPNRAYYGDLHNMGHIFMSYAHDPDHRNLEQFGVMGDPATTMRDPLFYRWHGFVDDVFVLYKNKLPPYGNDKLDFPGIRVSSVSVEGKAGRNTFATQWEQSTLDLGRGLDFTPRGSVLARFTHLQHEEFDYVIEVDNSSGKAAMGTVRIFMAPIADEAGNKFPFNEQRRLMIEMDKFSQGLRPGKNTIRRRSVDSSVTIPYERTFMNQNNRPGDPGSVEAAEFDFCGCGWPHHMLLPNSPGEPGSAEAAEFDFCGCGWPHHMLLPKGDNKGYPMQLFVMVSNWAEDGIKQDLVGSCNDAASYCGIRDRKYPDKRAMGFPFDRPVPAGVQTVKDFLRPNMAVTDCKIRFSDAVRVRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9I3</accession>
    <name>A0A0N1I9I3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460126">
        <property type="protein sequence ID" value="KPJ17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9I3"/>
    <dbReference type="InParanoid" id="A0A0N1I9I3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF4">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="177" mass="20236" checksum="B777B40853B2573B" modified="2015-12-09" version="1">MGGGLCLVYTVEEENSWWVGYFCYGLRPLQLRVCNSVGAEVLRVRRPYACTPRVLPCQLQHLQVFSPPGHLIGTIEQQWAAVRPVYLIKKENGEELFWIRGPFITLSLFRDVEFGIARADGVPVGSTCKRWQGLLHAMFFAPITDRFNVEFDRSLSVEEKALLLAATLLIDYMYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAP8</accession>
    <name>A0A0N1IAP8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinaldehyde-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAP8"/>
    <dbReference type="FunCoup" id="A0A0N1IAP8">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IAP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF166">
        <property type="entry name" value="LD40136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="227" mass="26183" checksum="9A35F2385B4D3CE9" modified="2015-12-09" version="1">MYPNWFQKLDPLDPKVAAVIDAGYLVPLPKRDAEGRRVVLSCMGRFDPHLYDSCVMARGHSMIVELLLDEPRSQLLGYMHVNDEAGMQMPHVSLWSLTDVRIMLNCIQNSTPMRHKCTHFVNIPHYGVRFFEFAVSLLSDKLKDRVMFHRTSEDLTKHVDPSILPKEYGGTVPLRDMVEELKKNLLKRREELLALDEMCVDLYALEKNDLTQDIHSTAGSFRKLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB23</accession>
    <name>A0A0N1IB23_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB23"/>
    <dbReference type="STRING" id="76193.A0A0N1IB23"/>
    <dbReference type="InParanoid" id="A0A0N1IB23"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="212"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ20183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="534" mass="59347" checksum="628820A890CE2CD6" modified="2015-12-09" version="1">MQFKGYLLEQITSQTEQQTSAEALSRVLENFTELKKQSKQPNLKELCEKFVIEKFTKKTSSVTQWMVIFEAECTRIGIDEDIQKIQTTRVDDSKLRAYTHEVVTLWYRAPEILLGAKFYSTAVDVWSLACIYAEMASGRTLFPGDSEIDQLFRVFRALGTPGETLWPGARQLPDFRAAFPRWPARPARSLLPEAARAQPHAAALFEAMLRYEPAERVPARAAAAHAYLADARLVPPRLPPAPSPAPTPASPAPTEPEGVPSTALREISVLRELKHPAVVRLLDVLLVDSKLFLVFECLHMDLKRLMDLTSGPLDLDLVKSYLRQLLEGVAYCHGQRVLHRDLKPQNLLVDAEGRIKIADFGLARAFGIPVRAYTHEVVTLWYRAPEILLGAKFYSTAVDVWSLACIYAEMASGRTLFPGDSEIDQLFRVFRALGTPGETLWPGARQLPDFRAAFPRWPARPARSLLPEAARAQPHAAALFEAMLRYEPAERVPARAAAAHAYLADARLVPPRLPPAPSPAPTPASPAPTSDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBH3</accession>
    <name>A0A0N1IBH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Regulator of telomere elongation helicase 1 homolog</fullName>
            <ecNumber evidence="17">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_03369</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="17"/>
    <dbReference type="EMBL" id="KQ461186">
        <property type="protein sequence ID" value="KPJ07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBH3"/>
    <dbReference type="FunCoup" id="A0A0N1IBH3">
        <property type="interactions" value="1519"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IBH3"/>
    <dbReference type="KEGG" id="pmac:106718982"/>
    <dbReference type="InParanoid" id="A0A0N1IBH3"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="974" mass="110082" checksum="98983B255A6CF1EF" modified="2015-12-09" version="1">MPEVMISGIPVSFPFEPYEVQRAYMEKVIESLQNNTNALLESPTGTGKTLSLLCSSLAWLLVKKAQLQMNAQVGNFSEHSGGGFSGNLKESLKASGKSKDNTSWGMPKIIYSSRTHSQLTQAMQELKRSSYRHVKAAVLGSRDQMCIHPEVSKETNNMNKVHMCQLKVKSRTCFFYNNVESKKEDRSIKGDDILDIEDLVGVGKKLKCCPYYLSKELKQDADIIFMPYNYILDPKSRKANGVELMNNIVILDEAHNVEKMCEESASLQIRTTDVALCIDEITHVMKSFVENNEEMDSTLDNTTPKDFTCDDLCILKEMMLALEKAIDDISVGSEGTTYPGSFIFELLSKAEIKDHNQMTVITLIENLIQYLSTANASPFQRKGVGLQKIVDLLNVVYSGTTHAYKERVKLCYKVHISVEDKKNKKSDSWGALKATSTKTSERVLSYWCFSPGFGMKQLLEQNVKSIILTSGTLAPLKPLISELGIPIGVLLENPHIVKANQICVKIIGQGPDGTPLNSNYQNRDNPKYISSLGRTILSFCRVVPDGVLVFFPSYPIMSKCQEMWQNDGIWSGINNIKPIFVEPQRKDTFNAIINDFYSKISDPNTKGACFMAVCRGKVSEGLDFADMNGRAVIITGLPFPPLKDPRIILKKKYLEELRVQNKDYLSGDEWYALEATRAVNQAIGRVIRHKNDYGAILLCDGRFNSPKLKNQLSAWLRDYINLSNKFGETVSEICRFFKNAETSLPAPRLKPLLPYESNVNYKESNAASSGVSFPLANTRIINKNPQKKSVSQYPNSNEVYADFSMDFYKNAQASNYLNEFRPKETKDLFSALDCSNDSVKTEQQPLVTIHKRNAEEVSLNAVAKKKKLKIKAFGFEENLTKINDSSNIERVAPESLIDFVKEMKVLLDGEKYKQFQVSISAYKKEGNYTKLLETLISLLENKKLFYLFKGMKRFLKEEHKLEFQKYCDDVKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC71</accession>
    <name>A0A0N1IC71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC71"/>
    <dbReference type="InParanoid" id="A0A0N1IC71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="9825" checksum="B861B3E55F6FC340" modified="2015-12-09" version="1">MTSTPKSEKCGQGYELPGVVQYSQAGLIQVRSAEMFGTFTVGVLRRAASAVPPRLYRGPHRSHGRRGCRPIDTLSCQSYAWPRTSSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEN1</accession>
    <name>A0A0N1IEN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 87A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01051843">
        <property type="protein sequence ID" value="KPJ21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEN1"/>
    <dbReference type="InParanoid" id="A0A0N1IEN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="2">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11345" checksum="3861719D4AE6AC9F" modified="2015-12-09" version="1">MMVRTNIETTMNLSVGVEMVAPSGYLSAAMWPLPRLGPALQRVGGAALCWAVLAGAEAWLRLRRRAAQTLLLAEAPISLLDSAICWWVFVSLAHTTRTLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEN2</accession>
    <name>A0A0N1IEN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette sub-family A member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IEN2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001253">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF263">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_17, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2542"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2595"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2619"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2645"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2721"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3159"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3398"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3440"/>
            <end position="3466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3478"/>
            <end position="3499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3511"/>
            <end position="3534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3594"/>
            <end position="3614"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2769"/>
            <end position="2996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="3625" mass="408063" checksum="DA73BF99FA43DA8C" modified="2015-12-09" version="1">MAASRQLRLLLWKDYLIRKRNPITLAGVVWGTVVIMSLYIVRINVDNQDYPTCQFPARALPTAGVMNFLQSFICSVNNECSPMEEYEEIPSYSKSKLTQIKQQFAPLFSNSSILETASSMPDALKLLATVSEVADVPDFVYIAKHGLRVKELFRNPDRVKRYLQIEIEIEEPLANSLMDSALSFEGIMQGKFNTCDIDSMTKTIKMDKNNMEMFVQKICSLSSSSIQKLTMDLLLEMDLGKYLQMLGNMYYKLSKDERMLDLGKMAGAVLRMASLQSFLPPEVTEILHNETPDFTYIQLDVISNVLDYFEPNFGDTQSFKFIRDFADSAVMVVKYLNKFLEKQRIKSFGTNNEQSTYSVKEENKLRSTVNGVSNIFSNAKEAFQDLTDNSVSIDIFNVLSRITNFIYKLLPDKTKHDVLFYSTLVTKLIEEAEKVIYINVHLEELMYNVTLRHPQGMEAVLSLPAHIFEKSLEALSDPERAQILTSKLDSPGEVFCDKRKLQKFFEIDVAEVAELHNKMCKDSLKEYLKDMIHSLGILSVRSSINAMASLFIQETLGKDTNSQLYSLDHDFDVLRNFSRTINNLDDEEPRHVNWSNVIDVNTNSDIVNIIRNKKHVGNHILVTVHGALAKAVVKQNPVLEYKIAPFLIDATTIIEALNKDIDNTPLEVAEKAKILYPVVLTTILTTALEQQKLFKLLTTFSLDSMCRGVVTASKYLEFPPDVNKEEVVTTLCNISDVFENVLKRDSNLGKAIKLIITGGGKTSGIQWTKLIEGLRNLYKKIDNFYPYLLEYKSYGMNEEMRRNVANMIKEVKKFWFSPRNWSMTLSMKLAFEILDLMDRDIFDITSDVWLQFKYGLGVITGPMLLIDDVVKLIQAILKNETITSPLPSDTVASLKQVIPYFPQLLHETVDLVARDDTKIEPIIEIMNANKSWPCSDTSLGDILKLTNSSKETVRGIESLLCMSQSTQNEWNLYLKSKYIFRDQSNLNSKDFGPHIFLRFSGAFDSFIEDFDIIKNILLDALDEPADSVTLMTAWRHAVDVLNNTQSVPILRNLFTKMDVVLNSIRVPVKSGTPLVSLWRSLLNCEGDCSDLARTTVLNILKFLSLTVSNVADDLLSYFKEINEPDANLLQLVGFTKKTSLYLLYERLPDFIGVLANSFVDFGFMSQIRRATQSTFWDCEAVVKSLVPAPGGPIDQDIIARVQPFVCPSFLYWISLPRGDNVIMDVVAKPQYYFFTSSVDDLNSTFESAYNKANELSTFMTELAHNKSNIKENINIDSMREKLIKSVDIMLNYKIDNSNPSYLMFNEANKKLLISTTYLTRIVTIINKVLDKIENVSVQVPNENEDKLKAMKDDISALKKIFKRRPTDGTAVFFDTITNNLLNNEENKLTNAFVETCNRLKNNDTTKDILIDNDKVKAQICQMNYDVIFSMVDTESDLENARLSLRHLVNVLRKDEEDVDDISKFLKSRKEIIKSWKLSIKYAYDLGIPVYLKYLHNNVQHQDVIITFLSGGNWWKKLRELYNGPFATTFLNNVEKIFDIADDILNNLDKIRWVRLIREINVNSKEDFCKSNVSMSEYIPDETGSLDSFKQQFCLDDTTELVKELMPLRFASQVFDSNLKISTDVNYTEINIDITRIESNLDKIINGPNPPQTPEWVTENKLKRFRSSAVALLSTETLTKASFGILANIVDAGTLLLNNSQCTLCSQFTTWFKQLNLQLYKKQEYDNLLCHLQDMDLVNVYHTLKNDFHWDMAIKELISFRNYTKFELNKSMNEFLELVKQHLLEDIMSPTTKISQCLTYNVTKNAFGNATLFAKVVAHTFKLIRAELPHLKEVDGIKEVEYLKDLQAAVAHRLDVKVPLKSYFSKGFDVTKNLKEIIKKEYLVKAVEDSKVSVQAINDLQPDDLIFKRNETWQDLCESCDCNKVINIIVNNLNRTLIDEDLPMLQDEEFWSFKFISNILEHFEALVGDVARLLGVVSTMDVWGVAQGRLVAIIDTAIQLLTDDTLGSIVYSLHGLTTELTPLIKAYDLQSNLLDVSRGLLVLQQIRNSLIEEDIKVPVSELFSDPEELEVELSALGINNTNFWSVAAPRIHAGHLQFKPILASKDTFHIRQLVCETEDLARVLVPANLDVVTLDDVLGALAEQFCDLDEDTAKKIVSVLLQNLDYSYFINNIKDWLLRELYAASDLPAQRGELVLDSFPQLAALLPTVRDSFERVSGLLADEPVLDYFKKDFSFDSLFGGGEFMAAAGRMVCGKPFNTQINRFFKSVVETKDLSSEADAEQLEVLPTDFCRSMYKQIVSVDGGKIVWSFVKPLVMGKILYTPVTPNVHHIIQKFSSSSAHYRGGLAALQQLLAAPATQAIKTELFGDVQIPEFDVEEIFNKLGDVQDLGSILQKGSNILECVNLNRFRPVSDEHQLSLEAVKLLRVNEFSAGLVFLNNESSLEVPLNVEYKIRMDIENVPTTSRKKNYLWIPGPESNFIDNMRYFRGFIQIQDIIDKAIIDVAADGLGKTLDVDWATYTQQEPYPCYRKDFFQTSIYESQSLIVAFFFSLLFTTTSVVRFIISEKESGNTVLMSVMGVNLSYHTLSWFLWSLGELVATAACIAAVLCAGGILPHTAPSLIFALLFLFAFSVLSFCYMMSKLFRGASVGAVCSGLAYLISFMPFVLILSLEAVLTSSLKFIVCLSMSSSLCYAFLYITRYEAMGSGAQWAQLWASPDGVDDMSIGLAALIMVLDGILYILIGLLLERLYGFKAHQVSVVDCEAAGEKAGVSVLNVSKVYGGGKLALDNCSLELHTGQITSLLGHNGAGKSTLINIMTGMLKPTRGSVVVRCGGGGAAGARLGVCPQRDVLYRQLSAREHVQLYAQLKSGRDLHELHDQIESILRVLSLGAVAEEPVWRLSGGTRRRLCVALAFVAEPGLVVLDEPTAGVDPAARRDIWSMILKLRENRTILLTTHHLDEAELLSDQIVIMHKGQIHTTGSPIEIKRSLGSGYKLTVMYPETRRRLNEVCDIVEDEEGCIEEKTKLLLATVRNVIRNANLMDVNGSEVEINLPFFDQDGVSSNYLELCLALESQQSALGFCDFSLDCSSLEQVFFTICHQADAPLQNVELDTPSKSASTSSLRNDKAPLVPREGPLVGSMWDQFLALLYARYLHYTRNRSLLFMLVALPSLFVLISMAFSNIRPPPNSEVALPLYRIYDNATEYLVKKPSISDDSVISSLFAQDIMNTLIAEKRARNWTDEDNPVCNCVVTKQECDLSSVNITNLPELMLLPDTTALNNWIVASHDVYIEKRYGGYSSVIKNNISNLVVWYNNKGYHAMPMYLSALHSAVLRAASGRLSANITTYTHPLKISDEPINKDTVSVPPADFVIIVSKIKGHIDFISGTKFNGCDVYYQHIADAGVSAMLLIAFSLASAGGAVRLVTARASHQQRLQLLAGVTPALYWLTALVWDMMVIIVNIIITAAVLQAFHFPVFVSRNNLPAICLLIFLYGYGCAGVVHVASRLFTQPSLANMILFCANTFVGVVGIALLLILDIISESDATDRARWVLHKIFMLSPQFTLGDGVLEIAKNTIRAQVLGQFGMETYQDPLSSDLIAYHYLALVLVGTVLHLLNLAIEYDCFEVLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF53</accession>
    <name>A0A0N1IF53_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicular amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF53"/>
    <dbReference type="FunCoup" id="A0A0N1IF53">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IF53"/>
    <dbReference type="InParanoid" id="A0A0N1IF53"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="509" mass="54798" checksum="20B916EE9F10F1A9" modified="2015-12-09" version="1">MGAASDGFGWRARIAACRESRKLVLVIVAIALLLDNIDELPIIPEFLYDIRHPDAPLSMSLDDVTVPPPPPTPYCPCLEKNTTVVYENVTHLNLTAEREERHKELIHETVAVGVMFASKAIVQLIANPFVGPLTHRIGYSVPMFTGFILMFLSTLIFAFGRSYGVLFVARALQGIGSSCSSVSGMGMLAERYPDDKERGNAMGIALGGLALGVLIGPPFGGLMYEFVGKTAPFLMLSALALGDGLLQLMILQPGVVRQETEPPSLRDLVTDPYILVAAGAITFANVGIAMLEPSLPIWMADTMEARRWQQGVAFLPASICYLIGTNLFGPLGHKMGRWLAALSGLIIIGLCLILIPMARKLEHLIIPNAGLGFAIGMVDSSMMPELGFLVDIRHAAVYGSVYAIGDTAFCLGYAVGPAFSGALVNSIGFEWMLVIIALLNFAYAPCLLMLRSPPARDEKQLGEVRGTAQRHDTAGRTSVHAHVSCCDASEGMDDELIKCKLSESYNGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFK9</accession>
    <name>A0A0N1IFK9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translocator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_03795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFK9"/>
    <dbReference type="FunCoup" id="A0A0N1IFK9">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFK9"/>
    <dbReference type="KEGG" id="pmac:106716223"/>
    <dbReference type="InParanoid" id="A0A0N1IFK9"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="18872" checksum="DD000CC14E9D0F26" modified="2015-12-09" version="1">MPNWNLIGSLIFPNVGGWVGAATTMAGQVSNGKGNTWYETIRKPTWTPPNWIFGPAWTALYTGMGYASYMVYEDCGGFNEKAVLPLALYGGQLVLNWMWTPIFFGMHKIGWALIHILTLDIAAAACAVSFFKVNSNTAYFMTPYLCWLAFATCLNHSIWELNKDDPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFW3</accession>
    <name>A0A0N1IFW3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">La-related protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">La ribonucleoprotein domain family member 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_04433</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFW3"/>
    <dbReference type="FunCoup" id="A0A0N1IFW3">
        <property type="interactions" value="1436"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFW3"/>
    <dbReference type="InParanoid" id="A0A0N1IFW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12290">
        <property type="entry name" value="RRM1_LARP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034887">
        <property type="entry name" value="LARP7_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF62">
        <property type="entry name" value="LA-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="15">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="534" mass="61003" checksum="CEB558856BF878B3" modified="2015-12-09" version="1">MPESESVETVDLKQESKLENIPRKRIRHRKRQLYDNIIKQMEFYFSDANLSKDRYLNELVNKDPYVPISEFLKFNKINSMTQEITDIAKALSHSTFLELSEDKLKVKRKTPLLPYDVDARTVYVESIPVKATQDWLKKVFSNYGHVAYISLPKFRNTQRIKGFGFIEFEKPQEAQKCINAFIKMGCKLPTCMPPEELSSIKMFSVDEPPNDANESKEEYEPPKKKNKKSKDKKKNLELKIENDSDSERRVETPSEETKSLATPPEDENKSLATPTEDENKSLATPTEEGKTTDAESKDEMTSQDESKNDGSPRRKKKIKKRKTKNGTKDKNKLNNTEVQNGLWGLQVLPKCEWKALRNKYLNLQRKYMKEARAMYHSKKNVYTAIPASAAPTLEGESAIKAQEIESSKTVAPLERIPGVFVEEMLPEPCLDVRLVKRTIKSNIHAQHVEAKEGLSEVIIRFDSAKAADEYCTNSNNRARVLCGAEEQEQWVRAEETRAAGKRGRRGRGREPAGPAPALAPASPQPTHTHIRFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGZ0</accession>
    <name>A0A0N1IGZ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGZ0"/>
    <dbReference type="FunCoup" id="A0A0N1IGZ0">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGZ0"/>
    <dbReference type="InParanoid" id="A0A0N1IGZ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000007">
        <property type="entry name" value="Rhomboid like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF8">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="47611" checksum="CC764F30F97689A0" modified="2015-12-09" version="1">MNSHQRETTVSVPLTPTRSDLYWRRIFNKYDRDNDGKISYVELKNIIESREYDHDLPDNVVEKIMALVDRDNSGYLDFAEFVEMMHNPDLKAVFGHFVARYVHSIIPHRDPVDTTGTWSGFRAVSTSDRGRKTRLVAQNYVAFPVDVACQVSATSKYAKSGTLRLNDVSTSFSRAIRTEDEPYGTYEEEYSCWPPAVCMIIISLVEIVLFCYDAAQGKTDATGPIAQIFIYNPHKRQEAWRFLTYMVVHVGVVHLLVNLLVQLFLGVPLEMVHRWWRVVLVYLSGVAAGSLATSLADPKVYLAGASGGVYALIAAHVATIIMNWSEMEYAIVQLLVFVLLASVDVGTAVYDRYWRHLQQNIGYVAHLAGAIAGLLVGIGVLRNLEKRKWEKRLWWAAVVIYFSLMIAGVLANIFWYSHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH41</accession>
    <name>A0A0N1IH41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel subfamily K member 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460643">
        <property type="protein sequence ID" value="KPJ13321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH41"/>
    <dbReference type="FunCoup" id="A0A0N1IH41">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IH41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="44148" checksum="0FFFA4E487419EF1" modified="2015-12-09" version="1">MPRRRRRLASRIRNYVRSLLAFLFSNIGLIVLVVGYTVAGALMFQAIEGASEIERVNNMTLERNNTAQYLWQNVTLALNLFNETALKYRFIAKIRSLMDFRLSILLVFPSIITNINNCLFYSGYGHLSPRTSWGKVLTIFYALLGMPLFLLYVTNVGQLLARWFKCLYALVCLCRGCPGFARRRVVRLRTQLETSEAESIECPEGWRHRVSESDVTPDYRIPPYPIYHQRRLDMRRLAHPLDVRYHDRGWSEPAYRVESEASDFSYVTFDAQTITVPISVCVAVMVGYIMFGSMIFGLWEKWDQLDGAYFCFISLSSIGFGDFVPGERVYTPRIETSFIVCSLYLMLGIALGAMCFNLMQEQVIHYFAGMKRALKRICRCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II25</accession>
    <name>A0A0N1II25_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035740">
        <property type="protein sequence ID" value="KPJ21295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II25"/>
    <dbReference type="InParanoid" id="A0A0N1II25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9082" checksum="E87237B88EA0DC5E" modified="2015-12-09" version="1">MGPIIMTGIFTITAAFVPKGLPQMILAIASRFSINMSYTAAVQWSTELVPTGARASGLSLVHVSGYVGNMLSPLIVYSVNNRHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIQ2</accession>
    <name>A0A0N1IIQ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase CHFR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459752">
        <property type="protein sequence ID" value="KPJ20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIQ2"/>
    <dbReference type="STRING" id="76193.A0A0N1IIQ2"/>
    <dbReference type="InParanoid" id="A0A0N1IIQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16535">
        <property type="entry name" value="RING-HC_RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="219"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="613" mass="71443" checksum="8BC79EC3ACACAD48" modified="2015-12-09" version="1">MQVNDVPFLISNKKLKPEYEDLERIKVSTTVLTIGRGLKNSVVIPFLAISRNHCIIRKTYDSWFIEDHSSYGIEVNGLKLGNGKHKKLKNLDVITLDPAKEFVYSFVNVAQTAEDDNIECEPSNKRIKLENNVDSTDIINDVKIKFENSQSSEMQHIAEKIENAQHIQKKSQLLKDHLQSEMRQKILMLNKFYTTRIDSLEDGKTTIEEQRALLIQERDRQLAALKEEMEGKISSLKEEIEKHSAIESELILENVSLKQKLLKEREEFLSEINRESSSKQDLLNKLEAKMWEQEEIRKMEKRKLEEKLRNETEMLKLANEKEIKELEEQKKLRESELLQALNVLKSKLESKEKETQQHKCEVEQELTRKVEQMKKVSKEEKLKMEQLIREREELQKKLTEAKINANKSIVELKTRVEDRETELAALAAERIQKHSEQSTEVINSLLEQLDKVKSQLRSVENEKEMLKAENETGEISAKESAVAEFTDIMENELQCSICAELFVCATTLNCAHTFCKYCITMWKKKKWECPICRKPITSECKSLVLDSFIEKMVENLSEEMKRKRLDLLKSREEDEAAQAHHPNSDNDRGSSSHDESEFNSSFDEGEEEEYEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IK63</accession>
    <name>A0A0N1IK63_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459659">
        <property type="protein sequence ID" value="KPJ20517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IK63"/>
    <dbReference type="FunCoup" id="A0A0N1IK63">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106712823"/>
    <dbReference type="InParanoid" id="A0A0N1IK63"/>
    <dbReference type="OrthoDB" id="6924815at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874010" description="Cuticular protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18881" checksum="085AB99571153BE6" modified="2015-12-09" version="1">MFKFVVLSALVCAAVAEPGVFLAPSTYTAAIPAPVTSTYVQQSSAIYPAAVPSIYSSLSYPHFIKKREAQFYNGYIANGAYVAPAALATPYASTLVAPAGLAAAYSPAVLPYAAPAHFIKKRSASASPQLLAAPLTSTYVAPAPIASTYITSAPFTATYPAPIYSSAAYYPYNAGFPFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INI0</accession>
    <name>A0A0N1INI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INI0"/>
    <dbReference type="FunCoup" id="A0A0N1INI0">
        <property type="interactions" value="1226"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INI0"/>
    <dbReference type="InParanoid" id="A0A0N1INI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="239"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="48035" checksum="7BD02360F4686A59" modified="2015-12-09" version="1">MPAVIKDNVLMYKGSNLFRQRLLLSVLSGRAIKIEDIRSNHDDPGLKEYEVNLIRLIDKITNGTRVELGETGTSMYFQPGILVGGQVTHSCCTQRGIGLKEYEVNLIRLIDKITNGTRVELGETGTSMYFQPGILVGGQVTHSCCTQRGIGYYLEVLLAVGPFCKEPLNAVLQGVTHHDLDVSVDKVKLAALPVLLKFILVDDGLELKVVRRGAPPLGGGEIVFRCPVRRSLRPLQWTKWGLVKRIRGVVYALRVSPTFANRVVESAKGVMLNFLPDVYINTDQCRGPNAGKSPGFGVSLVAETNEKTFYCAEAKSEEVGSGEISLPEEIGRQCALKLADEIYRGGAVDSSFQWLLALWMALGQKDVSECVVGPLSDYTISFLQHLKEFFGVMFKLEVLRSELDESDEEDDKVEANKVKMTCVGIGYVNISKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPQ6</accession>
    <name>A0A0N1IPQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460328">
        <property type="protein sequence ID" value="KPJ15659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPQ6"/>
    <dbReference type="FunCoup" id="A0A0N1IPQ6">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPQ6"/>
    <dbReference type="KEGG" id="pmac:106710151"/>
    <dbReference type="InParanoid" id="A0A0N1IPQ6"/>
    <dbReference type="OMA" id="IHLTLWT"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10765" checksum="6B3040C92ABC798F" modified="2015-12-09" version="1">MDFFTSIPTHIDYVGQAKAEKLYRAIITLFSIVGFIWGYIVQQFSQSVYILGAGFLLAAILTVPPWPMYRRNPLNWQNPKNTEEKPSGKKGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ42</accession>
    <name>A0A0N1IQ42_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ42"/>
    <dbReference type="FunCoup" id="A0A0N1IQ42">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ42"/>
    <dbReference type="KEGG" id="pmac:106721091"/>
    <dbReference type="InParanoid" id="A0A0N1IQ42"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="20022" checksum="1FA4F1E51873CD41" modified="2015-12-09" version="1">MDNDFENKIKELKSKIQSYPDFPKQGILFWDIFSEISDGSTCKLLQSLLVQTIKQNFPEVEAVIGLEARGFLFSFSLAAELGIGCLPVRKKGKLPGVVESFKYDLEYGSDILEIQKNAIRPGLKCLIVDDLMATGGSITATANLLKTCGAEVIGCVVVMELVTLNGRNNIPDGIPVCSLIKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQA2</accession>
    <name>A0A0N1IQA2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459670">
        <property type="protein sequence ID" value="KPJ20498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQA2"/>
    <dbReference type="STRING" id="76193.A0A0N1IQA2"/>
    <dbReference type="InParanoid" id="A0A0N1IQA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF7">
        <property type="entry name" value="RE45222P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19206" checksum="22D7F4491AA80A35" modified="2015-12-09" version="1">MLYRAINGDSAAGPERREDPGAPAPVPARYEGPPTPCPARVEYATPVFARNYQGVWRYVVQIPYEGYFTQTVEVTRCMQSRCHFLEGGCLSSPRWVSLLVAELHQQPQPSHEETLEGSSEKSIHCDTNTSQGCYQVRLYYDWFLVPGSCKCWRPDYFARYVRRHHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQG6</accession>
    <name>A0A0N1IQG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Period circadian protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01007978">
        <property type="protein sequence ID" value="KPJ20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQG6"/>
    <dbReference type="STRING" id="76193.A0A0N1IQG6"/>
    <dbReference type="InParanoid" id="A0A0N1IQG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12970" checksum="91C8180122BB288F" modified="2015-12-09" version="1">MIWSRLREYPGCGLHRTDHCGDLWRRPMPSILGRDNLVSSMVCRIRRYRDLASGFGVKNNAVVFMPFLLKLAFKNVKNEVGNEIYLVIQASPFFSAFKSIYIFTGLEEAVHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGC4</accession>
    <name>A0A0N1PGC4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGC4"/>
    <dbReference type="FunCoup" id="A0A0N1PGC4">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGC4"/>
    <dbReference type="KEGG" id="pmac:106711303"/>
    <dbReference type="InParanoid" id="A0A0N1PGC4"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="10">
        <location>
            <begin position="370"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="709" mass="79847" checksum="C5E9FF186CB53691" modified="2015-12-09" version="1">MDEKDDLSQLEELLCADLDGEQVETEKKPPCFKEVNIFEEASCLENIPNSSESLKASVIHNGDTDSSDDEEKRNYTERKYNDYGAEVKKLLDNKEKDQIDKKLNFEVRLRQANIDVKLAGHSSFSKKAIDNHEQKTKYIFGAPDTNSSNNKYKSDVFTDPIFGIRITRPLVSSAALLDRMQGREAVNMLRVKRYVENEDLSKDWVIAGVIVRKSLPKKSQKGSQFLIWTLSDLKDDIKTISMFLFQKAYHELWKTNEGTVVAVLNPNVLDRSQNSADQACLSVTSPNQVMILGESKDFGICKSKKKNGEPCTAVVNLNKCEHCVYHVKQEYQKFSKRQELQSSTMGKGLVNLQNKVLGKNTVIYGGKAYSALPKANNKKIKEKDQNRLMSLSDYYKSESDSNLMNNKAPYGAGSLKGNVTTLHSPTAQRISDSVRLNKLTQSSSNCNPKTEPSLAEKVANSPKLGRGFNLKGNGSIDLSVSYRQKTAEQIKLNAIKLIQRSGGLMKTDPNNIKGTEAGKKRALDKLNTSGTDENVCKKVKPNEDKNFKPTMSERFKKILEATSAHQNLIQQHEDDEQEKYFNKLEKKEAMEEKMLNTYKLACKAVRCTKCKYTAFSASQLCKDERHPLKVLDTFKRFFKCLDCSNRTISLELLPLHSCSNCGGSRWERAAMMREKKVAHCDSLSIRGEEETFIGGVTTGKNINLMVPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHI6</accession>
    <name>A0A0N1PHI6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein singed</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fascin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHI6"/>
    <dbReference type="FunCoup" id="A0A0N1PHI6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHI6"/>
    <dbReference type="InParanoid" id="A0A0N1PHI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23347">
        <property type="entry name" value="beta-trefoil_singed_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23351">
        <property type="entry name" value="beta-trefoil_singed_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23355">
        <property type="entry name" value="beta-trefoil_singed_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000008">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000010">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000015">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF9">
        <property type="entry name" value="FASCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="187"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="315"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="59295" checksum="9685E7CC0E16A312" modified="2015-12-09" version="1">MKRATAADAPRLPPHDTTLHRVKMNGVNGHSNGEAGGAGSAGDIITQNQQRGWWTIGLINSRYRYLTAETFGFKINANGTSLKKKQIWTLEPASGNANDSMIYLRSHLDKYLAVDSFGNVTCEADEKEPGSKFHISVSEDGSGRWALRNVERGYFLGSSSDKLTCTAKTPGDAELWHVHLAARPQVNLRSIGRKRFAHLSESLDEIHVDANVPWGEDTLFTLEFRADEGGKYALHTCNNKYLSAGGKLVETCTAECLFSAEYHAGALALRDASGAYLAPIGSKAVLKTRSTNVTRDELFSLEDSLPQAAFVAALNDKYVSVKQGVDVTANQDEISSHETFQLEFDWGTRRWYIRTMQDRYWTLEAGGGIQASADSRSSNALFQLEWQGSGAVAFRANNGKYLTTKRSGHLYANADQPDDNCKYYFYLINRPILVLKCEQGFVGPKGTRLECNKANYETIQVVRGPKGEVYREGKYWLADSEGVTCDSDLPQGFHLELREPTRLAVRAAQGGSYLAAHKNGAFRLAGPDLASATLWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHY8</accession>
    <name>A0A0N1PHY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin-XVIIIa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHY8"/>
    <dbReference type="STRING" id="76193.A0A0N1PHY8"/>
    <dbReference type="InParanoid" id="A0A0N1PHY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01386">
        <property type="entry name" value="MYSc_Myo18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036064">
        <property type="entry name" value="MYSc_Myo18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="425"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="519"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133630" checksum="596A4AD24FE82ADB" modified="2015-12-09" version="1">MFHIQGPFEQSLRCGDDVSPSGNKTLATLAKIHKHCTGKAHAHGCLDNKHNPLTKSDSNTSVQSKKSFRGDCFIEIKEAKSDNGFSRGNGSFTKSFSNSTSSYDGHSDTDSESTSKTRPDHKIAAPGERLFAQNTKASLMKTARMRYADDSVIATLNDEVDGEKWKQTFSRTPSRSSYKERKSGVLTIDELKSHGLNDDDVNGDEKKKSQLLNKHQSQRKGSFGNSGVIGNKQSNGSKPPWRGASKNGKVTEPFVRSPSLRGSVKKKKVNGVPWRRLYEFSLWRRCGVNFASDGAETERALLRPWKEMSSQESPPPFTAKSEEQLACEKEWLEAGHMWLAHRGGFTAVVREGDGDAGRAKVRVLHTGETLMVDEDDLEKVWKTSGMHTYKIDGDAGRAKVRVLHTGETLMVDEDDLEKANPPQLERCEDIASLRCLNECGALHVLRSRYAAGLPHARAGHALLVLGPPRRTAPIYTEKVAAMFRGCRADDMPPHVFAAAQSAHRCMLASRRDRAIVFLGRSGSGKTSAMRHCVWYLASAYPAQGSKLTPDRLNAALDVLHAFGSSRTSSNPHASRFVSLTSLDFDGGGALVSASVQTLLPDFRPGQSPLRALHTLFHGSDGRLRRELLLDQAPVNAPNPFLTSTDKAEAPAEFSALKEALQALSVTEPEQTVVWKILAAICHLGWCGVTKANAGSGLKYQFGSSGCASRAARLLGVAVDELSRAVFAPPAPTSPQTATALRFRSLFFWTPSPSSDREVPGSEALDAFVTGLYNETFNVVAALVNRSLSTSARTSASILLLDTPGADNPMCAGQQNGAPLSKLLSNYLQERLQAVFHDAMLVAPRERYAQEGITLDDGSEEDWLSETVNPGPMVELLDKSPQNSIVRSSQADLRDCDRRGLLWLLDEESMYPGSSDDSFLERALTHYGPPHHTHYLIKKAPHARQFLLQHLQGTNPVLYDVTGWVKASRENPVTKKAHTLLQESQNEDIGRLSSWSRGACGVGAWSAAVGDASTLRRASSIRRTLTSGTAGMKRRSTALQAKFVADGVVDTLRRCGAGGVQFVCCLLTNQPTDTNDDVNVPLLRSQFRGFQLLDAARLYKQGFPEHMPLSEFARRYRLLATSESETQENGQQTAALSDRQIVDDMLLALDLDVTSYRLGLTQSIKTLQLQYEDTMRKFGNNEELKWSDAFMAYLSKDFWQVKDRQRLLQRTPVAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ16</accession>
    <name>A0A0N1PJ16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01030744">
        <property type="protein sequence ID" value="KPJ21220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ16"/>
    <dbReference type="InParanoid" id="A0A0N1PJ16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="18512" checksum="AE54CB3EC0BCC643" modified="2015-12-09" version="1">MAEQQAVPDPRHPEAPRPPGAPLVVSLQRELEISGCCISPALRECAAIDAEVEEKLTAGSATHLGGICGGLIRLRVQTSRLLDVGVEAVVDNVPEFAQEVVIADNIEQVAPEVVQAPILVPADVLPASPPRHDFDREPQPLRCNICATNPLEVVLIPCVTTRNANLVWTVCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ48</accession>
    <name>A0A0N1PJ48_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-hydroxytryptamine receptor 3C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ48"/>
    <dbReference type="STRING" id="76193.A0A0N1PJ48"/>
    <dbReference type="InParanoid" id="A0A0N1PJ48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="41542" checksum="A014105277EC712C" modified="2015-12-09" version="1">MLRASGDAALGGTALHDQFCARWRPVQSRCTLCYVGVSRAACGNASALSERLDTLLAEYDRGASPAPRLPVRLALTVRHAALDERHSAVRMLADLQMSWEDSRLKWNTSVWGCGRAGVSAERLWLPDVVVVSAATRGVDPAASAGQRARLASDGRVEWTSRLDLSAPLALRLDDWPRDLHTAVFKFASRDHDSDQLDLTVAHAEAQTVFEAGAWELASVSHSTETWRRGDGERRVVAWALSLRRRAPSHALATTAVLSAAALLLLAALLLPPAARSPLCACASFTAAIWLISALVRLPGSATTPLAVELAGALCICGGLAALCTALTRRLAAVTATPPRRLRTALAAASALCSLAPESEGGGAGAWAAAALLLDRALRAALTVAIFIILCLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJV4</accession>
    <name>A0A0N1PJV4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01020396">
        <property type="protein sequence ID" value="KPJ21080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJV4"/>
    <dbReference type="InParanoid" id="A0A0N1PJV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879811" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11052" checksum="5F4C1438D0AA6569" modified="2015-12-09" version="1">MIVVMMLLSLFIPFVAKAIHDSSETKSLRKIVNAITVRSQGVQSEAKKNILQRLLRSIKCIPEPKLPVSSINMFIPTTELPKHSNNKRFIKNFKHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKI8</accession>
    <name>A0A0N1PKI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01013014">
        <property type="protein sequence ID" value="KPJ20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKI8"/>
    <dbReference type="STRING" id="76193.A0A0N1PKI8"/>
    <dbReference type="InParanoid" id="A0A0N1PKI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="10241" checksum="DBC260FEB2AA7EB8" modified="2015-12-09" version="1" fragment="single">VLVQGNIAWHSAIKISENALKNIQWEALAESEFPELRVHQLPLGERKLRVLSLNPTSTNSIVTNYYQAEITTPKDTAILELLMVKMLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKF4</accession>
    <name>A0A194QKF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKF4"/>
    <dbReference type="InParanoid" id="A0A194QKF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11976" checksum="A361141FC2AC34C3" modified="2016-10-05" version="1">MTSFETGARVSHYYKNQAKLVPAHNNSDIYREHTYAEQYFKMYTNPFERKHSALRQALDRFIRGETRISFRTKKPSLKNNGSNSSIGSATTMDFNTKYNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM18</accession>
    <name>A0A194QM18_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein regulator of cytokinesis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM18"/>
    <dbReference type="FunCoup" id="A0A194QM18">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QM18"/>
    <dbReference type="InParanoid" id="A0A194QM18"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="359" mass="43314" checksum="BA131249104C23B1" modified="2016-10-05" version="1">MVAITEDVRNLFNEVLQEISQNIYHMMEELWTNWSHLGVDNAIKISNITKLVQIEKDLHREVILETQQKFKTMQSQIDKLKEETEELSRCLSVDITIMDFKEDMLLFDYKKELENQIAGYREQVLQRRMKMERLLEWQKDIGEKLGTTIYELQDVPLPSEEELDKLKNHLEVLQAERDKRVEIFLNTQVEIKDIMEKLHIKPQNKFEQLVVSSLSVDFKVTDLNMDRLAKLQQDLQDKYQQTNNRVLELRERLAKLWDCLEEDHIYRENFLQAHIGCNPDTENALKEEIRRCDQIKRQKIQVFVANVRTKIKLMWDNLMYSTKEREEFVHYYQDTFTEDVLTLHELYLEKLTKHYNEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM56</accession>
    <name>A0A194QM56_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM56"/>
    <dbReference type="KEGG" id="pmac:106719812"/>
    <dbReference type="InParanoid" id="A0A194QM56"/>
    <dbReference type="OMA" id="ECYVCAY"/>
    <dbReference type="OrthoDB" id="7344163at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264471" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22545" checksum="7F097C05B976813E" modified="2016-10-05" version="1">MVRWRMFLLLAILLLLPTRSHNKLEDDDDDERNEEDDDDEEGEDEEEDDVDASEKTDTGPGRRAPAILPTPKTVPVSRTTPKRALECYVCAYKSEAPLKACLDPTKYRVHTITCHSVDDKCFTSVIAKGNAYEAVIRGCRSGCVGSPETTCCELNRCNNHALNLPVVVPHSVKSKSSKSFPPTVFFFVTVLLLLQTVGKVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM84</accession>
    <name>A0A194QM84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein fem-1-like CG6966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM84"/>
    <dbReference type="STRING" id="76193.A0A194QM84"/>
    <dbReference type="InParanoid" id="A0A194QM84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="123" mass="13704" checksum="C5E16EB3F54551AE" modified="2016-10-05" version="1">MLVGAKVGGATPLVIACRNGHYDVAEYLIERCKADIEQPGSGQSIRLHQRPSIDVRKTCESNTNPLQSNHMIIIWSDQVQTILGLNIPTAMRQAADRAVWKQLVDISVKALQDEHEEEEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMS5</accession>
    <name>A0A194QMS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tctex1 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMS5"/>
    <dbReference type="FunCoup" id="A0A194QMS5">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMS5"/>
    <dbReference type="KEGG" id="pmac:106719730"/>
    <dbReference type="InParanoid" id="A0A194QMS5"/>
    <dbReference type="OMA" id="YVIRPNF"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="17098" checksum="E41D66D5FB7E0E28" modified="2016-10-05" version="1">MADDEEVEEGEGVEAIQSGTEVSPVETEKPLAPAKYEVRPGLGEKFQAQNVRDLINRTMKEQLMGRQYRSDQAPKWAKSIANAVRQRVQDLDMKRYKILVQSTIIEMKGAGVKCGQRCIWDPETDAYVDDLFRNDTMFCYTIVYGLYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNV9</accession>
    <name>A0A194QNV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peritrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNV9"/>
    <dbReference type="FunCoup" id="A0A194QNV9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNV9"/>
    <dbReference type="InParanoid" id="A0A194QNV9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF107">
        <property type="entry name" value="LD20793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="22541" checksum="450AE42BE6F2E13C" modified="2016-10-05" version="1">MSPLFLYGNGQTYAHPELCDQFFLCTNGTLTVETCENGLLFDGKGAVHNHCNYHWAVECGERKADLTPYSTPGCEYQFGIYPDSQECSTSYVKCAFGIPEQEPCTPGLVYDERIHGCNWPDLLQPFCNPEAVIGFKCPTKVPSHSQAAKFWPFPRFPVPGDCHRLITCVEGQPRLIACGEGKVFDDQSLTCEDPELVPHCGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP10</accession>
    <name>A0A194QP10_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP10"/>
    <dbReference type="FunCoup" id="A0A194QP10">
        <property type="interactions" value="1159"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QP10"/>
    <dbReference type="KEGG" id="pmac:106719213"/>
    <dbReference type="InParanoid" id="A0A194QP10"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BCNT-C" evidence="9">
        <location>
            <begin position="858"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="843"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="939" mass="107138" checksum="84A80FA566C69298" modified="2016-10-05" version="1">MGKVRSAPGAPRKQGFNKSGHSMNPDRPTEGLKGVGKPRTKATIKRLQMYRNFKAKRDKTGKILTPAPFQGWLPSGTQARVEPNQKWFGNSRVISQNALQKFQEEFGAAVKNPYKVIMKPTNLPITLLNEKAKHARVHLLDTEGFDKTFGPKKQRKRVNLKFNDIENLSKAAEISSEKYDESKDIDLVREDTGVREGQRDWVFGAGMSKRIWNELYKVVDSSDILLQVLDARDPMGTRSPYVEKFLKEEKPHKHLIFILNKVDLVPNWVTQRWVAVLSAEYPTIAFHASMTHPFGKGSLINLLRQFAKLHIDKKQISVGLIGYPNVGKSSVINTLRAKKVCKVAPIAGETKVWQYITLMRRIFLIDCPGIVYPSAETDTEKVLKGVVRVELVQNPEDYIEEVIKRVRRDYLIKTYKVDGWETSTEFLEKLAARTGKLLKKGEPDISQVAKMVLNDWQRGKLPFYVAPEGFEVPLSKQVEKQTEVQDEDKQTKIQESEDKAEKNIKEVVETPEQPKLIVNKLVIAQDFAKIRVGLPFDNEQDVKPLQEIEIPEELKGIDDGDENDKSLNESQTIDENDKKEDENDSDSDISNFYSNDEKECSDVEDYLTNNPETVKELKRKRLEVASGTFTVEELPNKTAKVKSSIVGNKLTAKQRRALERAQRRTKTGSNFYEVSNMSSGSESDEDYVPKEAEQLSEEESADDETEAQYENEVDQKTTKRKAVQRKTKKKKKISNGDKEESKDEKELDKVETKPEDEKKREDDLWAMFLEGTDTKPKSANNSKTETQPTKTITKCDTLPSKNTSTNNTTTSTETDKEKERRIFEFAGETIIVENNVIKEKIKTTETSPSVSKTIPTRSRGGGGLSNVLGQLNKKNKLSTLEKSKLDWDTFKKEEDIEAEIKSHNKGKQGYLERQDFLARADERQYEIERDLRLSKRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPM3</accession>
    <name>A0A194QPM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPM3"/>
    <dbReference type="FunCoup" id="A0A194QPM3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QPM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="266"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="690" mass="78219" checksum="E8A78E2FD819412F" modified="2016-10-05" version="1">MSGTRVVLTDHVIKVLQVPYLENASAHSRIWRRFMTSYISLGYCGILDAGLRVPKGFFDGNADDPGNYYQCLAIDAPFGDSRISGKYCVVQVPLSQDLTLPGFSGKADALNVNKLKLGPAAQLVLEKYYTGIKGYRALSGTHLDDRVAHVTGTLFKLAVCIPRPCTTEVAVTTLLFNLSTIGFDYQEQFCRLPNDKPWVSADSAALLIFFMIGLLTLMSSVYELTHIFLLKKDPKSVNIYYRSFSIFSNTHSLFNIPKEPHTLMCLNGIRTIATVWIIVGHSFSSLSGLLNPFRAWEWMISFDGLWVSSTPITVDTFITITGILLVFTTAKKMDAGSLLRNLHIFYLNRLLRMFPLLATAVLFDASVFHRIGDGPYWMAVATNAQKCRDYWWTTLLHLQNYLNPKDICVPHSWYIAVDVQLHILSPLVLYWILRGRKQTAWFALLLSLIVTLIVSAIYNGFMDLPAHTISPARNDRIMEYMTKYYFHIISRIAPFLVGMMFGYILHLWRGKRVLINAFTVQGMWVVSLCIISGTLYMLYRVKQLDWNYRAADAALNTLMRPLWAAAVGWMVLACAHGYGGPINWFLSLPLWRLPGRLTYGMYLFHYPIIVVVNGTIVGLQYFSVANVMYQALSFLVLSFILSFILTVVIEEPFTIIFKSLLDKGFSKSNSEEKKLGEIEAFEIESRKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQI7</accession>
    <name>A0A194QQI7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras GTPase-activating-like protein IQGAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQI7"/>
    <dbReference type="InParanoid" id="A0A194QQI7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000013">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1638" mass="189168" checksum="2F9DFAD1D0C76C01" modified="2016-10-05" version="1">MGNDIGETFIGKIDDCDRDVRKTGQEMDIIRERTVAYEYLCRLEEAKTWMEACLKEKLPHPVEFEECLRNGVYLAKLGNFISPELLPLNKIYDIDQRRYKIMGLQFKHTDNINKFLQVLKRTELPVTFQPETTDIYDKKNMPRVIYCIHALSSHLFKLGKAPLIHDVFGKAVFTDEQLDSVSKDLQNCKHPLPMFQKNGGILSRNDVDNNTILNKAIVELNNLLDTEKPITTAILNPCLKLKYVQNQLIEVYKEVLKNAKHDKIQVALNHSLNESYVPDDFDEMLTVVEIQGHITATNFRYLWKKLCSACQHNDINSLHKTFNEEWVKINNYEYSNLDFYCDVVKEIIDSNKDIDVESVINWHKIFQNIINEGNRKAFEHKDHKSAICIVNKSLDEGNPNDLYAALKNPNLGLNMNIDKFAMPLLFEEMRLEKCELERNLNENEIAASVAYLSSIAYISRAVEMGDEAAVWNSLNSNQINLENLRPHCRRRYFAALVTALQVKFKEQFQCPLLTLEDIRDAVEMVNIKDDDNEELVVLIDSINKTVSTEDTTTLITLLKNPVLKLPVTLHKEEYHLCMRTLKKIFHQKESQNLWYDDILNAVNEVHVESMKAKELTEALVQLNMAVIKNNVNEFWNILTSPILSVSEIIEEECIEVYFHKFTKALWKRRHYICPWIVCHTEAGNTVYIDIESYNYSWITPKDFVPHHRYLTKKDVTVIVEKTNKQEFNSQTEGLSEKKLTKFQAHCRGYLVRQATIREKLYRENEDLIIKIQAWWRKILAEKKYGTLIKMKTIEAKLRQEKKRNPWAWYKVQEHKIIKIQALWRGRRARRAFVSLFHSPNPPLKVVKKFIPILDFATEDYDREIELQTLKSEVVQSIRKNQELSKQIDDMDLKIGLLVQNRIALQEVAAHGLKLNNLVKNNSTTKLVFQNREGKGSLMTISTAVKGLKSLTKESKRLLDGYQHLFYELQTNPTYLSKLLFCIPQNKTNFFLQNVVLSLYNFGAYARDEYLLLKLFRFTLEEEISCKVCKPFDIIASTPLVLKMAVSLSRQLSGLNSLQSIIGPLVEMMLKDKDMNIETGPVEIYKAWRNETEMKTGQISDEERLECGLLHTRNEIYYCEPSFDFVLLVTSFPDALMHHTCTRTSHISIINSFVHHSSRRKSPDIAELMSVAWRVIGNLVYYQFLNAAIVAPDAFHIINMPNGAGLTTDQRKNLASVAKILHFSAAKKGFGEESSHLRCLNPFIVECHEKMNELFRRCCRGPTLEEYFAVDEYTEATLLHHPHIYITVQEIVDTHALLVEYQDILAPDPNDRLNDLLEDLGEVPTVAQLASRDVDSQGADVEENARLEVCLALVNKFQAPADDMTDLNKLFIKTKELCVAIIPFLNGEHLLEALCIGTTREQQELYNEKVQKRIYSGQARPDEAMSLREHIAKLRRNLQMLEDEGYVTREDGYQALVTSIALDLCNKGKYRQAQRRALATLTRTKQSLIEKTKYYEEKCKSYDQYIKSCLANLHTGKKSVHACLRRSGKDIQKLKSKLTVKYTGAKLLERGVLLEIDGLAKSQFKNVQFDITPTDNFGVFTVKGKFMGVEMESIEIDIQDLLQRQYEGCAVMDLFGKAKINVNLLIFLLNSKFYGKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR74</accession>
    <name>A0A194QR74_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR74"/>
    <dbReference type="STRING" id="76193.A0A194QR74"/>
    <dbReference type="InParanoid" id="A0A194QR74"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase D-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="303" mass="34689" checksum="DE4D1FB5F91BABDE" modified="2016-10-05" version="1">MLLASAAAVVVVSQVAKKICKYIFNSSKHTENEVANDDTCSEVIQIKNREINDVILFSDDIVRHTIRIPPNKEITICESRELNCFKLIKYIKSARETLDVCMYLITSTEITEQIIRLGQKHVLVRIVVDSDMAYAPPSQIKRLEEYSFIQVQTNKRSILMHHKFCIVDGPKAIKRKLLLRAHAEKLNVHGHLTRKITNQFPKIKNTKGFVMSGSLNWSTQAMVSNHESVIVTSHPNIVSKFEKEFESLWVENEPTKFAMHALTWIRALKDEVLVVKENIVMHTFANKFKDMCEVNQSALGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR76</accession>
    <name>A0A194QR76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA dimethylallyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR76"/>
    <dbReference type="FunCoup" id="A0A194QR76">
        <property type="interactions" value="1971"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR76"/>
    <dbReference type="InParanoid" id="A0A194QR76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="269" mass="31863" checksum="0211645DE96A9EC7" modified="2016-10-05" version="1">MNQKMSDPRSAMSIELWLKTGRRHSEVLDEQKMSEGQLRRPDATIVLWLKCEQTIHDERLNARVDSMLKEGLIQELLNFHDRHNKQRIKDGKPPDYTKGVFQTLGLKEFHEYLMMTEDDRNSEDGKKLMLQSIENMKIATRRYARRQNKMVKGRFLEIPRREVPTIYELDTTDLSQWDKQVKNKAIDIIESYINKIPCPYEPLKKNIDEEKNKINSQSSNYCDVCERLIIGDKEYAIHLNSFKHQRVLKKKKKLLDQKAKEIQNISQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSH1</accession>
    <name>A0A194QSH1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSH1"/>
    <dbReference type="STRING" id="76193.A0A194QSH1"/>
    <dbReference type="KEGG" id="pmac:106718496"/>
    <dbReference type="InParanoid" id="A0A194QSH1"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF456">
        <property type="entry name" value="CD63 MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="235" mass="26165" checksum="5D5F65158895707B" modified="2016-10-05" version="1">MKVPKVLKSVRYTLAGVNTIYWLTGVLLLIVGIVAVVEYSYYNTLLTRRFITLPGFVIATGVIIILTSVLGFYGAVSENFYFIAAYVVLLLTTLVFEIVMTVVAFGLKNDAVSEIRAPMIQSVQFYETRRDIAKLWDDLQMEFECCGVAGRHDWARDRIPVSCCHIDYGTVSPFVCTTANSYLVGCASVLGEWLSYYAYVIGVVAAIVTGVQLLITVASGWLAWRSKYEEVELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSV5</accession>
    <name>A0A194QSV5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSV5"/>
    <dbReference type="FunCoup" id="A0A194QSV5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSV5"/>
    <dbReference type="InParanoid" id="A0A194QSV5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF27">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="532" mass="60365" checksum="6342EFD018186C20" modified="2016-10-05" version="1">MLAASVCGSDILMITMGGTKSHKMPFWELARGMIRRGHNITLMSAFPPDFHIPGLEEIAPEGLASYVRGYMTFDLVGARMRGEEPLPLYDILRYGYEACEAFLDDFETRSFLRSGRTYDLIILDGAYPECALGVVYRLKVPFMYINTVGFYSGPASMSGSPAPYSVTPFFGRAFTDNMGFIDRALNSAWLVGSIFAHGFSMTILQGVLRRHFGQQIPHVYDMAKNVSFILQNGHFSVSYPRPYLPNVAEVACIHCKEPKKLNADIEEWIAGAGEAGFVYVSMGSSVRTNKMPLAAHHMIVKALGRLPQRVLWKQDAAQNLTDIPSNVRLYKWLPQQDLLGHPRIKAFVTHGGLLSMFETVYHGVPIVSIPVFCDHEANAAKAEVDGYAKILNLQYLTSDKLYRAIKEVIDEPKYKIEVKKRQILLRDKKETPLERAIYWTEYVIRHKGAYHLLSPAKDLNFFQYYLLDVAFAFFVILITISVLIAFVIRRSFNWLVDYLQSRRMDKLLDNSSNILKSSKKLYDSKTIVKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT66</accession>
    <name>A0A194QT66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT66"/>
    <dbReference type="STRING" id="76193.A0A194QT66"/>
    <dbReference type="InParanoid" id="A0A194QT66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="5">
        <location>
            <begin position="217"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="413" mass="48603" checksum="B0FD6D5D32E4A94F" modified="2016-10-05" version="1">MDVNLVIKEYILPLFQDTYCRKSGSRPEPDCDTAKINRGWCPKKTVAKANHPNELPGSVLEETEGDVGQIGKHISKGSVTINRDEYLHAHRELTHDYQQLKMKNNLLHRRFADYYKKRKLEHVLKPLENSADLEEKYQQKLFTYAELKDKEEKEIHDIKTKIQAVENQFKHNLENAEQKCDELIQLERSTGTGLIYSKTGKPMGEKTIERFLTLQRHKSEQAAQLCLRYIRVRNAVAELEVVIRKLETLGPGLHVAHFEQMYIDKQNYMNKIEEREDELIKNRTKCTEHNQILAHIREKMHHTDEVIDFTEGDLGDADLEFLKARERLGHAKGERDKLRWSLESERMKAGLLTRRDLLRDFQDATDEVVNLKERKCHLMNQITKIRHKLRESRRQYQFQPIAAEKDEELDNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTE9</accession>
    <name>A0A194QTE9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc finger protein 865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_13019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTE9"/>
    <dbReference type="STRING" id="76193.A0A194QTE9"/>
    <dbReference type="InParanoid" id="A0A194QTE9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="611" mass="70548" checksum="4F6C9535EE9FFA19" modified="2016-10-05" version="1">METKVADMRSVEEIIKRNLMARTKLAKIIHEADGTVRYECVECPAQYYDKEKLELHLCKHNDEYRYLCGICGTGLKRKEHLERHTQEHLEVRPYSCHVCGKAFKRKEHLNIHLAIHSGGKPLECEVCQKTFYRKDHLQKHMLTHNKHFLGDMLERLAERDGVTIKQEMEEEEFLTPIITSVSGSVGDTKIKMEIPDVMEDSEGDQPIRPVPVINDSVYQKMRPYVCNICNKRYKRRDHLKVHSKTHMKKTKVCSECGLGRLGTYGHVKNAEDWHVTRNAINMNVVYVCRAFHYDGQLLSHINSVHLQAYRLEGDTDGIARLKIMLGDKAQLLIASDGTDLLVPRVKKTSDERPHVCHICNRKFKRKQHLKVHGNVHMRVSQPTIWCSLCNEGFFANDQFERHKCTPWERGESGSSAESGGGQTTHEAKKENICSQDYVEVIEEPQENGSIEDQEYLEPRQSNDEVGDVGETGEMGDVEEMCLPVPRRVYVCKYCTKPFKRKDHFKIHLHIHTGIKSFFCPVCGKGFYRKDHLQKHTQVHSKTRPARRRLPDLYPISMLNKEVVPEITIHAPSNTKLRVPLQIKVPYQMVMSMDNGEQRAITIDPQASTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTJ4</accession>
    <name>A0A194QTJ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTJ4"/>
    <dbReference type="FunCoup" id="A0A194QTJ4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTJ4"/>
    <dbReference type="InParanoid" id="A0A194QTJ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="535" mass="56550" checksum="A53426F90E08DAF3" modified="2016-10-05" version="1">MILPLLPSLLDYYDKEEGKGNSLYASLVYAVRSFQKLTGAPDRFASVLFGGALGSMYSFLQFLTSPIVGSLSDAYGRKPMLLICLLGIAVSHALWSCASTFSMFVLARFIGGLSKANVSLSMAIVTDASGEKTRARGMALVGLAFSIGFIVGPMAGAWFAMTTDTNFGLWGQRPALYALSLSLANIALVSLLLPETLSKLGIAVSHALWSCASTFSMFVLARFIGGLSKANVSLSMAIVTDASGEKTRARGMALVGLAFSIGFIVGPMAGAWFAMTTDTNFGLWGQRPALYALSLSLANIALVSLFLPETLSKDKRAPFSLSLSKAIEYVSPWHLLKFSAFENLSQHQNKVLSKLGLIYFLYLFIYSGLEFTITFLTHHTFAYTAMQQGKMFLVIGVIMAVLQGGAARRLGPRGAETAARLALALTPASFLCVALAACADPVLLSPITWLWAGLVLFALSTAFAVSCMTSLAAAQAPAGARGAVLGALRSLGALARAAGPLLASAAYWCSGAAVTYSLGSIVLIIPAVMLFRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN5</accession>
    <name>A0A194QUN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN5"/>
    <dbReference type="InParanoid" id="A0A194QUN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="430" mass="48687" checksum="652BB52C3B1D4A48" modified="2016-10-05" version="1">MSDRLKLTKATNHEDKFQFAETRCTELQEKLSDIINSKRRKNLKKRSATGINTMGKMSEFNSDYVTIRKKNPKKQCKEETVCEWDNEFAQTGNNVATGKNSVGKMSESNADYVTKKKKNTKRQCKKETTYCEWDNEFAQTGNNMSPVHEDNGVRGDGENHASKSSRHSVIYKTRRRPNDANENPIRPVVELFNINRSESSGDTWQENYAASQMKHSGGGYAAVRGTPPAPLAESYTESGDESKRSKKIRKVMKFMVRRYELPTVSSRSKQRNTKAYEPSTNKAHIPFVTSKSVTPSHNVGLNIQQVLHGLKINQPISEIPSTMAHHMGLRHCTSDAGVKAEVQVKKLNVLKLGKITLTLPKYKSMSFDQLLRLYESNNVIVGKFLKTASCRKSMPFLKKINPPKALPFNCHTEDSDDQIDQQSYSSKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN7</accession>
    <name>A0A194QUN7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exosome component 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN7"/>
    <dbReference type="FunCoup" id="A0A194QUN7">
        <property type="interactions" value="2047"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUN7"/>
    <dbReference type="KEGG" id="pmac:106717304"/>
    <dbReference type="InParanoid" id="A0A194QUN7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="449"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="735" mass="85198" checksum="8663E5D6350BB3BF" modified="2016-10-05" version="1">MNSTLNPNAPDFYPELKKVTQDGYLTIKRAVKSSKIFTTGKFDSLKTLPAFKSVTSDLCRYVTSQIEEIVFSETPKVVFTEEDGEECKEEKIAQSINNILDRVNKNLEALCEMEKLQTTDKNDQNIPPKEEEPMNEEQGQIEQHDLYEGQAMATTSNTQVYNIENIWVPILPEKPNFLVPLQLKLLYDSNGKAIGYEHPYKIELDIYEPPSNFTNIVPEPIPFPAPLKNTNYKFVNTLSKLEELVRHLREVDEIAVDVEHHNYRAYRGVTCLVQISTFRGDYVVDAMVLRRHLYKLNYAFTDPKKIKVLHGADMDVLWLQRDLGVYIVGLFDTYQAAIALDLQNKSLKALLKLYCKVNTDKKYQTADWRVRPLPYEMVKYARIDTHYLLYIWKRMKNQLLELNDGEKHKLMKVFLSSRDVCLSTYKKHVVTETSHLSLYQRYHTDFDLSTRSLAALKILYKWRDDYARELDESPAYVLPNVLMLTLAEKLPTDLKSIREYCPSAKKVLKRSFVKILEMLKTCREMPEPSPPVMPLAIRPLDEFSYHMLDLPNANTSDENGDVVMEPERIVHESYSAAVKYVTSSPTGSDDNRFCSPYLRYVKCVKVEKEEKKNDKKEVVVAVNTNTENDLTEFTPIFKSKETREREAEERAKENPEAAMEADNAGEGTSNDFTLVTRRKRKARAKRDAQDAEDKVGNKPTPPTKRVYYQYTNPNYKNFYTPRDKAIAKMQLKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUQ3</accession>
    <name>A0A194QUQ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUQ3"/>
    <dbReference type="STRING" id="76193.A0A194QUQ3"/>
    <dbReference type="InParanoid" id="A0A194QUQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="9787" checksum="43DB3551B1BC8117" modified="2016-10-05" version="1">MGESIEVEDSLDLEYDMWDGQFDFVGPQGPPPVTRGRITSDISITEDLFTGTPLTPHLTNGVNGGKKTAAHQWCDNLSDQVRIYFILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV20</accession>
    <name>A0A194QV20_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV20"/>
    <dbReference type="STRING" id="76193.A0A194QV20"/>
    <dbReference type="InParanoid" id="A0A194QV20"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="24047" checksum="8CFAB1032AE3B897" modified="2016-10-05" version="1">MAVRLSLADITFKKRCKVLSIYDQAPFDHNRTALPVSILTQVMTEDRKWFVSLEPEAQALVLLELVSVAGGPVVWQVYARAQKIYDRYREYEIDNLKESMVVAETAHHGKTSHHADLAHHMKKDPLRRKNGDSLSAIKDVTTAEGSSGKAQKKLDECMVVWNGTMKLIRDSFKLEEIETTFNDGTKKRIWKVDRPMPEAMETVDFVCVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV35</accession>
    <name>A0A194QV35_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV35"/>
    <dbReference type="FunCoup" id="A0A194QV35">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV35"/>
    <dbReference type="KEGG" id="pmac:106717507"/>
    <dbReference type="InParanoid" id="A0A194QV35"/>
    <dbReference type="OMA" id="FYLWSQW"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF20">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="24253" checksum="23D0CE9A5C54FF98" modified="2016-10-05" version="1">MESAGAYGGGKAGGAFDPQAFIQRPPVIVRAVCWLFSVIVMGCISAKGWYVNKEDGKEYCVYNNDTNACNYGVGISVIAFVASIAFIAGEYLFEQMSSVKTRKHYVLADLGFSAFWAFLYFVGFCYLSNAWGKTDNPPVGTANNMQGAIAFCFFSIFAWVACALFALQRFRMGADAAFAPAYEVEGAIGSPGSFPAYPGAPDPQPAYSDPPFTQTGNIDYTAPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVS2</accession>
    <name>A0A194QVS2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ras-related protein Rab-23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVS2"/>
    <dbReference type="STRING" id="76193.A0A194QVS2"/>
    <dbReference type="InParanoid" id="A0A194QVS2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13669" checksum="BA738F1647A997B0" modified="2016-10-05" version="1">MLLRVLQEVENECGEIPTIIVQNKIDLMDQCVVGPDEAELVARALGCRLMRASVKEDVNVGAVFRALAARCLADMRADDDAPSVNTTPVIGSFTNHNSNGTILLRPAKHRPGKKRNVFKSACRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY99</accession>
    <name>A0A194QY99_PAPMA</name>
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        <recommendedName>
            <fullName evidence="1">DUF4746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY99"/>
    <dbReference type="STRING" id="76193.A0A194QY99"/>
    <dbReference type="InParanoid" id="A0A194QY99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031827">
        <property type="entry name" value="DUF4746"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15928">
        <property type="entry name" value="DUF4746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4746" evidence="1">
        <location>
            <begin position="33"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="235" mass="26426" checksum="C21DDD13BA2D9C9E" modified="2016-10-05" version="1">MARQAIEYTVEARRMEREAKKIEILKAGNLKALEDFERSTLDTEVDIVIPEALSDEELEASSEEENEDEYFPPAGLLIPGFYAPPNEIAKVNGLAVLFPKIVLESVTPQPEFLPPHVLVLLDMTKRYKAVEILVKHKSAVIHMGIFQLNDPLFSNNLHVAYSIKQFESLQLNTNLDNMKLAVMLSVQIDLPLLCLMDLSPCYVSRDATAGEADCAAIFPVDYGDHYPEFEDFDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ64</accession>
    <name>A0A194QZ64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin-likey domain-containing family A member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QZ64">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ64"/>
    <dbReference type="InParanoid" id="A0A194QZ64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="375"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2175" mass="247162" checksum="1349D9728915936C" modified="2016-10-05" version="1">MENKKTAPATQQPLTQQHIMAHHVHPDQIYSSQYTQIPTHVATQTNQIQPNGVMHQLLQSQYQSNMNARSPLLENRHELYGTGHNREYARHYGANDNYNFPQSPPGQERTEIHTDQNVNHDILHNIPKGYNAEVYQDYLKRNPPKDTNQIYQNHQPTYRPNANQYGSKPYLPYSSRIGPQSNTELLRRQYNEIQQMKMQQQLHYQNQAQMHQQQKFAERQLLLQQIHGVQPPPNLQNSLYSDGSYRDLDRYSSKNDFKDYEPQKDMEAYAKNNEMRESDKQMRQYHDAQWQANQPSDFREAERYRKPEDDKAKSQSPPSDYNNQTQRNNVSVVSPMKSSESSTPSVKSPSSESRRSSSGNQALRSPIAQRIPSAPVAMSGILYKQGSDGLKVWRKRWFVLSEYCLFYYKSHDEEKLLGSVLLPSYKVSACTAEDKVMRKFAFKLEHANMRTYILAALDQEAMTKWVKALTMAALMQNFIDQPQKQSDRMVAKNEDDEDAGPTYANAPPKPRRSNDGYNSPSPDMYDPNYDLLKKPASHYSQGTNNTRYQDHTNYPSSPMQDAAYTRSPQSPPVQQQPQYQTKRSYDTHNLSLPLTNTITERLESNQYGSSSMYRSNPQSPYFDNRNRNQQPQQQPIHDPKANNDANIYEQRMQRNPFLQDNEQIETPRDRESQMKNNQSMTEENRQSQESTPNASNTYNKDVYGELNRPSRSGSSVNERLIERRTPDAYGRAASVAYNKERVEDYEDIYGNENEYGKTYAKSPKQHQARDNISISSHKQAQDQVPNYPQEKTFSGPAVLRRKKMQASGIQPPMPRPHSADFLEYESKNEVLNKTVPTRTVTDPPRQPQRPKSSLDINSYYDPSSDRYYSEESYAEKMRQSAQYLQQQAIGSRNIQIPLAKYASGLAEKQLSSAYSQITNNNYEPDTGINRSSRDNYSDIEGLNSNWTLKEKESQKDYLNRSGSVMSDSSNVSGYVKDVNRFDPTADGFMRSASARLPSTTEKEGEKKIQQREESMKRLLEWKQRMLQSPLTRKSTPATISLARSLNHSRQSLRSDQFKPKTYTNASYNSYSSDDEEETTGTDLQIPRDTQAGRSHKQNISPIVMRPDTHAPFVAQPTSNVLTEVNKDKNDENTYENINCSVKNNFDCDIAREKNDVQNCETVSPENANEIDNNSGYETHDSESESETHIEYTDNDLDEVLLASDNDSKIVEDLVLKTLQKTDDGNDVEQQATEKSDTPPVRPIGEEHYLPMSPRKTSTLEPPHKTILQNLSVFDDTMPQHYEDNPYVEMNLGNEEDDMQTYEIVCVNNGKVEPVYMEVKNGTIEENELESVTLRDKSISDTASNFADTKQQTLKRVSKGDKTKERSDCSDADDESSRDFSLDTPFNRMSISDTFRPASYYLSDSKTTLHLQDSSDSEVYPPPPIPSSSPPCEELSGEALSRYILDKLDKSDIPQDSSILKMLTSENQKKINAKRKTTSLMIYGSRTSIHDTLTRGEKIRNSRASLVNEKQNFKEGPSTFHNNLIFEKNPCCGLDNDSVHNIFNADRGSSRLSLESDVSSKFDITPSNISSEVTSLGSDSMMDLNNSSQRDIENMIKRRPLSDDSLFELTSSQLYQNHDVISNADLDKYLENLQPCSSNVGENSYENTSFVRDSTRDDVVHSDDALPTQSFTVAHQRSSSTPVRNGNAADDKVDIGIQYRILEQHVSGYVGSQSSCSSVGITKSPISFYCKNTDEGTLIRKNLNKNSTANKIKEFENEKLAPKPEIDTNASSTTTGFHSRESSTEHSAPYYYSDLSSQEHINVLPTSHFLKNTNLHRKLNNQRRRGPLHKKNEISHIHNPIRNNHVLMSDRSFELASSARSVSVEFLSAADKDSDIDMKNIYESTGGKSSKIPESMNLISSLGCKSSSQRRIDESQSTDLSILNNASMNTSSIQLSSASMSSHCSGNSSNTVYYDAEADAGAYENVLCQGEKHWDEDSLWRDNLRRVSHRHARSMDDLDTVQVETEPNRIGSDACCMHSIKRIKKCSPSKINRNVTYVNCNIQEQAQRRKDVNLDTKCMYSEEDVKIDDNDVYVSLAEDSEQCNEQSDEGVYEQLAIGSSISSLPPEKEVQKCVVDSKSTRKKFEIDRENLRQWDLMSSGLMKGRAGGAHCVGANVVVGTVHTDTGTDRSSNDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZS4</accession>
    <name>A0A194QZS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZS4"/>
    <dbReference type="FunCoup" id="A0A194QZS4">
        <property type="interactions" value="2337"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZS4"/>
    <dbReference type="KEGG" id="pmac:106717278"/>
    <dbReference type="InParanoid" id="A0A194QZS4"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000813">
        <property type="entry name" value="D-Importin 7/RanBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="877"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1046" mass="120184" checksum="4147DF731F5F1724" modified="2016-10-05" version="1">MDTRKLAEILRATIDPNQRQQAEDQLTQIHKIIGFTPSLLQVVMSNDVQIPVRQAGVVFLKNLITSVWQEKEAEEGEPIPFSIHEQDRAMIRDMIVDAVIQAPDIIRVQLCLCLKTIIRHDFPSRWTQVVDKIHIYLQNPEASGWMGALLCLYQLIKCYEYHIAEKRVPLMEAMNLLLPMMYNLIVNLQPDQSADSALIQKQILKCFYCLIKYLLPLDLITKEVFTKWMEVFRAIMERPVPEHTLQVDEEERLELPWWKCKKWAVHTLYRIFERYGSPVNVRDEYVQFAEWYLSTFTSGILEVLLRVLDQYRNKIYVSPRVLQLTISYIDQCVSHSHSWKLLKPHMFAIIQDVIFPLMSYSEADEELWNTDPHEYIRLKFDIFEDFLSPVSGAQTLLVSCCKKRKDMLERTMQLCMQVLTSQNGEYGPRQRDGALHMVGTLNDILTKKKFYKEDIDSLLSQYVFPEFRNPLGYMRARACWVLHCFANVPFKNEPLLMEAVHLTVNALLTDTELPVKVEAAIALQMLLVLQDKVQKYLEPQVKAVTTELLKVIRETENDNIANALQKIVPLYTEQLMPMAFEITDHLATTFSKVVQTDSGTDEKAITAMGLLNTMETVLNVMENNPKIMAQLEKTVLRVVGYILQGNLIEYYEEAMTLLCNLTAKSISEDMWKVLELLYQVFEKEGFDYFGDMMPVLHNYITVDTNAFLSNENHILAMFNMAKAVLNSDAEDDSETYAAKLLEVMVLQCSGKIDNCLPSFVELVLNRLTRKVKTSELRTMLLQVLIAILYCNPPLLFTILNKLQESVPNASITQHFFKQWIHDTDCFLGLHDRKLYILGICTLLEMGPQRPNIDELVPKILPSCLVLFDGLKHAYEAKAEADDDTSSEEDDDEDEGAEVLSSDEDEIEEMNNEYLENLARMAVKNSAEQNVTITAKLEEVESDDDDDDYVPDESAIECYTTPLDDKDCPVDEYVNFKNTLLGLSAREPALYHALTSVLTEEQQKELNAVFVLADQRKAQQDSKRIEQSGGYSFTVPAQVPTSFKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZZ5</accession>
    <name>A0A194QZZ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZZ5"/>
    <dbReference type="STRING" id="76193.A0A194QZZ5"/>
    <dbReference type="InParanoid" id="A0A194QZZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10633" checksum="49EA26360AC4AE24" modified="2016-10-05" version="1">MGVAISRYSDISSNELLARFCSAEIICPNDPFWNQLLAFNIQLPNNTDEQLIFDSSAEALLQKFLQNNLQTGNLGSLVQVFITRATELLAAPNSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0B5</accession>
    <name>A0A194R0B5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein fuzzy-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fuzzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0B5"/>
    <dbReference type="FunCoup" id="A0A194R0B5">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0B5"/>
    <dbReference type="KEGG" id="pmac:106714887"/>
    <dbReference type="InParanoid" id="A0A194R0B5"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026069">
        <property type="entry name" value="Fuzzy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559">
        <property type="entry name" value="INTRACELLULAR TRAFFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559:SF1">
        <property type="entry name" value="PROTEIN FUZZY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="170"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="287"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="411" mass="46375" checksum="862B30D6C3E8B617" modified="2016-10-05" version="1">MSAIVIAVATESGVPIFSRKRGNNENIQFSTIASLHGINMFSKCHNLSVINSQVENGSILWKEYYKSVTLIGIVTGGLECDLELLLACIHDVMVFCVGKKELENLKNIDQLKRDLRQCYPILDYLLESLDPNSVPSMTLVLDLTQSILCSQAQHLQQVLDTYAERVTGRWACLSIHGHLVATSSDFYELDPRESRLLLLLAAAQDGAPLRDTLVYLPYMSPDVAFRAVTCKLLADVYVLVVCGATPALSQIDEIVLQCWEGYAQIIKEAKLVHPRNFPGSITFEPCVLGIFLININRRRCVFSRHLQLSNQKGRGMSGSHRMDILRTFYVTSARDLAPELNFREILDKDSDESLGKITETYWSSEYHKCHAQRSTNLLCCVLYAPTIPTHTMRLLTSQMLQEFLTNKDIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0K8</accession>
    <name>A0A194R0K8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0K8"/>
    <dbReference type="FunCoup" id="A0A194R0K8">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0K8"/>
    <dbReference type="KEGG" id="pmac:106714901"/>
    <dbReference type="InParanoid" id="A0A194R0K8"/>
    <dbReference type="OMA" id="FVYQCAH"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="14362" checksum="E590ADD57657027A" modified="2016-10-05" version="1">MGQIMGSYNARNVDLYMDDKPTFDPQDGFSFERKQREMLARDEDLISARIPPSKRDYCAHHLLEYQVCRYKNMPMLYRCAHEKHNYLNCEHQDYVLRMKEFERERRLRLRENRLVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R175</accession>
    <name>A0A194R175_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein Rheb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R175"/>
    <dbReference type="FunCoup" id="A0A194R175">
        <property type="interactions" value="1445"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R175"/>
    <dbReference type="KEGG" id="pmac:106714900"/>
    <dbReference type="InParanoid" id="A0A194R175"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="182" mass="20816" checksum="1234AAD6A7310088" modified="2016-10-05" version="1">MPSKQRKIAMMGYRSVGKSSLIIQFVEGQFVDSYDPTIENTFTKFIRLNSTEYEVKLVDTAGQDEYSIFPLQYSMDFHGYVLVYSITSSKSFQIVQIIYDKLLDMVGKIHVPIVLVGNKTDLHLERKISTEEGKRLAEKWKAAFVETSAKRNESVTDMFHAMLSEIERSDGHIQEKNGCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1L5</accession>
    <name>A0A194R1L5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1L5"/>
    <dbReference type="InParanoid" id="A0A194R1L5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="28794" checksum="4F3F7D92A6D8B3E0" modified="2016-10-05" version="1">MTEKRSGVYSVPPGGTGLRRTAIFLGWLGGSLGTLLTGWLAGSLSILLAGSLSGLLAGSLSGLLPTLMSGWSDVLLVALISGWEFASRFGIGEFMPNSQIMTWAGESMCRDEVATQAICSNILFLIGGWNEDQHNATMMPAIFGHTPAGAAVRQFAHYGQSIAGKEFRRYDHGLLRNMIVYGNMRPPKYNLGNVKIPTFLHYSYNDPLSQVEDVYRLHEELGHGIKMLLPLPTFSHLDYMWGIDAKTVLYDRVINLMKSVGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R200</accession>
    <name>A0A194R200_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like subfamily C member 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R200"/>
    <dbReference type="FunCoup" id="A0A194R200">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R200"/>
    <dbReference type="InParanoid" id="A0A194R200"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="232" mass="26787" checksum="02B8665548285C88" modified="2016-10-05" version="1">MSQSQIPKTRIPFMMLRQRQQKIILSIIRNISSSPRLCASHYDVLGVTPKSTQNDIKSAYYKLSKLYHPDISSTEASAKKFRAITEAYEVLGNIKLKKMYDKGLLTGRENTSRMDYTPDVEPDDPTVKFYKSHSKRQVAPTMDGKTPIYDFDAWSKQHYGDLLQKSVYEKEFLKKKAAKARELQHGNQQETLFYTLFAVGCLFLFLVVYGQDDYDRDRVAKNNTANKETVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2E2</accession>
    <name>A0A194R2E2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2E2"/>
    <dbReference type="FunCoup" id="A0A194R2E2">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2E2"/>
    <dbReference type="InParanoid" id="A0A194R2E2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF21">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 1, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="129"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="478"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="601" mass="67627" checksum="CD949B5A4F51048C" modified="2016-10-05" version="1">MHLCCKPFLSEGRSKNVIENKQSGDVEKGRIEYLTSSVPWSKVMVIVVAMCVLVAACATTWIFQDWQTSIQVFAIIFVVYVILFYWRWLWVALRTAKRDFSALYCYLKILSLTRSFSKKNFSMPEIFHNVVLRHPDKACFLYEDETWTFKQIEDFSLKVSAALKSKGVKRGDTVAVMAGNYPEMPAMWLGVARLGAIAPLINTNQTGNTLLHSINVAKCNFVIYCSEFDDAFQEIKKELDPSIKLLKFTRRPLNVSSDSVKVVEDSNDFTGLLENTTPAAWSPSDSDGFNGKLLYIYTSGTTGLPKAAVISPSRMVFMASGVHYLGGLSPKDVIYCPMPLYHSAGGCITVGQAFIFGCTVALRNKFSASAYFPDCIKFNATAAHYIGEMCRYILATPPKPTDKQHKVRTVYGNGMRPTVWTDFVNRFNIKRVVEFYGATEGNANIGDILIADELGYLYFRDRTGDTFRWRGENVSTTEVEAAISRIADQRDAVVYGVEIPNTEGRAGMCGIVDTDGSLDLERLVKDMARDLPKYARPVFLRVMDSLDMTGTFKLKKVDLQKEGYDPTIIKDKIYYLDTKSEKYISLGPDEYEKIKTGQIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2Y8</accession>
    <name>A0A194R2Y8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin glycylase 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2Y8"/>
    <dbReference type="FunCoup" id="A0A194R2Y8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R2Y8"/>
    <dbReference type="InParanoid" id="A0A194R2Y8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="881" mass="101393" checksum="CFB377B644909357" modified="2016-10-05" version="1">MAITMALEESTSDSKLHKDSTNKKELRPLSAVSYSRSEHGPETTSSVEQLKQYKSWVSTERWNELKKIADTAMKDHKVFMIKGGGFPAVRRALTERGWIEKYESHKVRHPPANIDPKKVVGKELTKVERMILYKFMEHHSVDFLWTTKRDKYDWLLSNKEVVISRSIFTTKEGLTASLTQMHWYTDPGTALTNFPRCYNIHNSDNLEEFIEDFRTTACISLVKWFCQMFEPNNENNPITNCGKVPFSAIEFAINRLNEYIVFYSHKDIDNVDDEIQHIWEHEWDQFLTHHYLLVHEKAKFMADSNVNVRQIERRASKALASIAKYWPQLDIDGVLNIWIVKPGNKCRGKGIQLMNNIKDIIGLLNIPAQKNRYVVQKYIENPLIIYNTKFDIRQWFLITNCQPLTIWIYKDSYLRFSSQIFSLSNYHESVHLTNNAVQTKYKNNGERDKALPDENMWDCHSFKAYLRQIGKSELWDSKIYPGIKQCLIGAMLACQESMDKRQNSFELYGADFMLTEDFTPWLIEINSSPDLAPTTSVTARLCPQCLEDVIKVVLDRRYNADADTGTFELAYKQVIPKAPAYLGLSLCINGRRLHKKQLKEHKHHHRSVTPLAPRTQIGDVIEDALQPVPPEYSGPIITDFLTWLNPYDSLPTNKDGILLGPKDSLTVRQAVTVIKANNTLKSGLKNRKTSALSSRIRGRREKNQESRRRVVRHSCCRPDDDQEAKLSRKYRTESARKLDKPKIDMSVGNKRCYIDPVEWERETDSILRSTISVQNKLAARTENCTKSLAPVRKAKSGLVGVNQKSLLQPMSSRSCANDSNSLKKLSAIGRNICRIQNENRVKQKSIIFSKSCTSIYPNYGVVVLPPNSETPNALFKRKTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R399</accession>
    <name>A0A194R399_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R399"/>
    <dbReference type="InParanoid" id="A0A194R399"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="481" mass="56373" checksum="732BD115AB4BDED2" modified="2016-10-05" version="1">MATCRACLETNKEMRTFDEPFAIQYNLLTELEIVKDEPDSTITTENCLYSEVKSELKEESMDSAAFNNIYNNDNFETSEKFELPLFSISNVTSEATKTKRILKKNKIKQSVKFENEERKQLNKKKNKVKMKKPLKNEEEMKLTTKMKEAKIKRKLKEKQRAAELNLKKLCGICKASFEDSKELFDHLEGHKKDKMCQLCHETFTEWPEILGHRFRHTPDSQRRCHLCNKSCTSHVYMEHHYRKMHYDGSVRLKCNQCDRTYDTPRNLRKHKSSVHSDKQFICDDCGETFNTKGKIKTHVLRHTTAKPHVCKFCGYSTKYVSSLRDHKLRKHTALKVYCKGCGTVFSCQEKLDKHVCKQKSRVCPICGLKMHKSERIYSHLKTHEKEKPYKCELCGNTYMSKVALKAHLDKHNGNRTKQCEYCPATFYYGSALIKHRRIHTGERPYVCKTCGKSFTSNSNLKVHRQIHGEYLINKMVKTEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3G5</accession>
    <name>A0A194R3G5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264889" evidence="1">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="361" mass="42028" checksum="1280FA795EA13FEF" modified="2016-10-05" version="1">MVNTWWLFIFLAKMVLANNNQVSSEESQKASRFLPLFEVKRFDGRPGPLAPGPGGLPPLTSVPVVGERCSARLESALNQLKRKKRNHAKNIDMPLSQSIDLNGYSLYQEMRSAPVDMYVTRMRVRLPQNSDWVRVEKCYFDPRNISLDTMLLFHDITISGNVDLYDANEFDRTASNRRQRTYPDEENSYKSRGNGCNMILRLRKAGIGFHTTPLNQQPGKFNVKTDSEFVEPGFISVYAYGCEKYINKNSVRNKDNLPLRRKRRSDEFTFDPRLDERYSDILEQSSDVWKTYEPRSRVNYERSKLFRPDDDLDEIEDISREMEDIFTKGIRTLLTTYMKKELQPAIKDTLMRNMGYVVSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3J0</accession>
    <name>A0A194R3J0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-tocopherol transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3J0"/>
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        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106713746"/>
    <dbReference type="InParanoid" id="A0A194R3J0"/>
    <dbReference type="OMA" id="RMEKEPA"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF38">
        <property type="entry name" value="HL01515P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="111"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="308" mass="36069" checksum="89D924B8D10FE968" modified="2016-10-05" version="1">MELLYDADGTPFVMWGENQIQLERMPITEKEYLEKAEKELRETPEIVEKAVEELREMLRKDTSLFVPLQDDSYLMKFLRPSKFYPESAFKRIQAYYKFRQSHESYCTNLVPTAVKPAFDHSIISILAPRDQHGRRIMLVESGERWQHRLVPLSEVFRGVQLALESAMSEPRTQINGVIVILDMKGLSFSQVMQFTPSFAKMVVDWIQDCIPIRLKAVHIVSQPYIFNMLFAIFKPFLREKLRSRIFFHGSDKQSLLSHVDPKALRKRHGGLLPEPEISGEVLWKMLHHYEENFKVANSYGYVSNNNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3M0</accession>
    <name>A0A194R3M0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3M0"/>
    <dbReference type="InParanoid" id="A0A194R3M0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000505">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="646" mass="70270" checksum="91ED93BF68015A3A" modified="2016-10-05" version="1">MVNLIADGITFSFGVFYPHFLEYFGEGKGKTALIAGIFMAMPLLSGPISSFLTDRYGCRRMTIFGAILASIGFVISAFVDNVETLFLTFGIMAGFGLSLCYVAAVVIVAYYFEKKRSLATGISVCGSGIGTFIFAPLTHILLEEYGWRGTTLILAGFFLNMAVCGLLFRDLPWTATMNEERAKERKRKRERKRNKRLAASADSISDSKSSASGSIKVVESGDIETVSSPIVPQFSSLVDLPTFMTGGEGVSLEVFEMMSNKGRAYAIMAQNYPGMMLPSRSFSDSGRLHEQSPPRALTSPGTASPGALSPGALSPTTPPPPQENTSNSVHLGDKAAVALWLRRQASGSTKKPPAFLKDLRIHRHSLTYRGAMLNISRYRLRASSCPNIFRNSMTTIAKEKVQWYAGLWDFWDLIVDVLDFSHFRNPAFLVFTLSNFLLYMWYDVPYVYIADSGISLGFNESQASMLISIIGILNMFGEILLGWVGDWECVDASAVYACCMLACGAATAAMPLLRGYASLAAAAGAFGAAIAANYSLTSIILVEQITLEKFTNAYGLLLLIQGVANLAGPPLAGWIYDMTNSYDLSFYLAGVFIALSGVVFIILPLYNRVKRYHQQRNTSASASASVCSEEPNIANGHLKVNGKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4E9</accession>
    <name>A0A194R4E9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_06692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4E9"/>
    <dbReference type="FunCoup" id="A0A194R4E9">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4E9"/>
    <dbReference type="KEGG" id="pmac:106713545"/>
    <dbReference type="InParanoid" id="A0A194R4E9"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="61"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="322" mass="36313" checksum="000FD77AC6E19C8B" modified="2016-10-05" version="1">MGNLKVALIDLLENAQVFPIVLSVGAVVVVATVIAHCVWGKKSAPTKKKSAKKLVALVDPDTKYPLPLIEREEINHDTRRFRFGLPSKEHVLGLPIGQHIHLSVKVDGDLVIRAYTPVSSDDDKGYVDLVVKVYFKNVHPKFPNGGKMSQYLESMKIGDTIDFRGPSGRLQYAGNGLFLIRKLKKDPPNRVPAKKLNMIAGGTGVTPMLQLVRHICTDPSDSTEMRLLFANQTEDDILLRDELEKYQREYPNQFKVWYTLDRPKEGWKYSTGFINEEMIKEHMFPASDDVIVLMCGPPPMINFACNPALDKLGFKETQRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4T0</accession>
    <name>A0A194R4T0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_06659</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4T0"/>
    <dbReference type="FunCoup" id="A0A194R4T0">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4T0"/>
    <dbReference type="KEGG" id="pmac:106713554"/>
    <dbReference type="InParanoid" id="A0A194R4T0"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="399" mass="45442" checksum="9AA4CDE94559D4A1" modified="2016-10-05" version="1">MDFNLNIFTLNCWGIPGVSKNRKERIEAIAKYLMQSSHNIVCLQEIWSEKDYLFLKDSLKKVLPYSHYFYSGVLGSGLCVFSKWLIQDVFFHQWPLNGYIHKIHHGDWFGGKGVGLCRIRYEDKLINVYCTHLHAEYHEDDMYLAHRVLQAYSTAEFVNLTTSPADVSILAGDLNTAPGDLSFRLITQLPVLIDPYVMKCEGNNSAIAKATGTCDNVNNSYSDAKMTKTAPEGKRIDHILFKLSNSWEADVVNFGNPLEDRVPGEDFSYSDHNAVSLELRIREINAKKTSQRQQSADDRFDNTINQAIKVCQDAKITITKSKRLFLTCGGLLFMFLLGTVGFWPNNILADFVKIVITGFCFYYIIMGTIWNKIEMNSLKAGLSALENFNRTRNELKCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5Q5</accession>
    <name>A0A194R5Q5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_14835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5Q5"/>
    <dbReference type="STRING" id="76193.A0A194R5Q5"/>
    <dbReference type="InParanoid" id="A0A194R5Q5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000011">
        <property type="entry name" value="Prolyl alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="15">
        <location>
            <begin position="528"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="690" mass="80233" checksum="D86D28D165713D3F" modified="2016-10-05" version="1">MKKENVIRGDATREESDRTSNEPLWTEAEVYTAITELAPLLPTLDRIIKDLEYFIEKEEIRADTLKTQLKMYEKEKEIVSKDYSEYLENPVNAYILIKRLTFDLDYLIQNVQNITKQNGTINLRHEDLKYPTLEDLVGSALALSRLQNTYELNVTKLAEERLTNASIGQLNMYKKEKEIVSKDYSEYLENPVNAYVLIKRLTFDLDYLIQNITKQDGTIKLRHENLKYPTLEDLVGSALALSRLQNTYELNVTKLAEERLTNASIGNSMTVNDCFKLGQILYQHKKFKHSLEWLIEALRKYKKENVTYGVSEILILNYISYALYYTDDAKTVFKSTKQTLDIDKEYAIKIEDSISALQNIEMLEELPSMEDTSAENEESSEEYQRYFRKEQFVYEALCRGEIDLPTETCNFKKMYDIEIISIPRLKCSYLTDTHPFLKLAPIKTEQLYIEPDVFVFYNVISDEEIEHLKILSKQRLKRSEVAGYSDFTNETIAKYRSSKTAWLYDYDSSVAARVSRRAADFTGFSTATAEPLQIVNYGLGGHFSPHFDFFLKDSEPELPKMKKYGNRIATTIFYMSDVTQGGATVFTELGLTVFPVKNAALYWLNLHPSGEGDITTRHAACPVLRGSKWISNKWFHLVGQETIRPCNLEYQIENVKRKTFMPRPKTSNEYHRQLIFDWFTNNGLEKCMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6M3</accession>
    <name>A0A194R6M3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">apyrase</fullName>
            <ecNumber evidence="3">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_10520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6M3"/>
    <dbReference type="FunCoup" id="A0A194R6M3">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6M3"/>
    <dbReference type="InParanoid" id="A0A194R6M3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000001">
        <property type="entry name" value="NT5E isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1201">Platelet aggregation inhibiting toxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="14">
        <location>
            <begin position="309"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="515" mass="57034" checksum="A7994FE2D2F1CBAB" modified="2016-10-05" version="1">MSSLDTEEFVETNPAGGVCNPSVAPCIGGFARLATAVREALAREPDSLLLNGGDSFQGTIWYNLLRWNVTQDFMNMLPHDAHVLGNHEFDNGIDGVVPYLEHLKSKVVAANIIDDLEPTIQGLYYPSIVVERNGRRIGIIGVIISSTNELASTGRLKFTDEVEAVKMEAEKLHKNGTDVIIVLSHCGIDIDREIAQNGGPYIDIVVGGHSHTLLYNGDPPENSTFQPQGSYPVVVRQGLKPVLIVQAAAHAQYLGEIKLHFDNQGNLVNWEGQPHYLGNEVIQAPDVLAKINQYLPEITEMATRKIGSSLVHLSSRCACSECNLGSFICDAYMDAMVARAKGDKWIDAHFCVVNRGDIRVDMEPGVITFETVLLSTPFENNIEVFELRGDYILEMLEYSVANIPFPGARMLQISGMRPIFNGSHPVNQRVKSVSIRCIDCPVPRYEPLELNKYYRMIAPSFIANGGDGFYMIAENRRNVEVVGVDYDLLIRYIAKLSPVFIDVDGRIQIQDPCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6Z5</accession>
    <name>A0A194R6Z5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6Z5"/>
    <dbReference type="FunCoup" id="A0A194R6Z5">
        <property type="interactions" value="1838"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6Z5"/>
    <dbReference type="KEGG" id="pmac:106712456"/>
    <dbReference type="InParanoid" id="A0A194R6Z5"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010474">
        <property type="entry name" value="AP3D_dom_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06375">
        <property type="entry name" value="AP3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01354">
        <property type="entry name" value="BLVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit delta" evidence="10">
        <location>
            <begin position="719"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="774"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112197" checksum="0599284B72888D84" modified="2016-10-05" version="1">MALKKVKGNFERMFDKNLTDLVRGIRNNKDNEAKYIAQCMEEIKVELRQDNISVKANAVAKLTYLQMLGYDISWAIFNIIEVMSSNKFTFKRIGYLAASQSFHADSELLMLTTNMIRKDLNAQNQYEAGLALSGLSCFISHDLARDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVVCELARKNPKNYLSLAPVFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPGHAASVQLCVQKLRVLIEDSDQNLKYLGLLAMSRILKSHPKSVQTHKDLVLTCLDDKDESIRLRALGLLYGMVSKKNLMEIVKKLMLHMERAEGTLYRDELLTRMIEICSQNNYQHVVDFEWYVTVLAELTEMETSAKHGCILAQQLTEVGARVAGVRAFAARECAALCARAAAAPPGPASREVLYAAAYVLAEYCTEQSVMRDSISPLLGCAGVGGAHMRARAVCVHAALKLCARLLLVYEQRNDLLAAQSVVGETLSGLKPLLCSEDMEVQERAHNASAMLTLLLARLDPHHPDILALPDSDSLTDTEHIATLVQHEHSNGIELNEQLTNGEETSQGFSGGLIEELASLFEGELKPVAPKAQKKVPMPADLDLKKWVCRERWSSESSSSEDEGEAGAGAGAGGAGGAVFTAPAQETRPLSHLTPEELHMLREARRQEQANNPHYLKDDSPRSYQQDDVAAVPVAELALEVPLHIHSKRSDKYLKESTKKAKKEKRPTKKRKAKQAENHSTDSDSDEEAERMVRPAVEEGGELPEGAAPSDDEPTRDDPHRALDLDLDLPLREEELLATRIQQYPSPDGGLLEKKKSSKKNKTSSKNSSDKTSNKKKEKKTKRNKDLDLMLPEVDKKDVPETTFIEDLEQGKENAERATLANTDSECRDQHKNKTDKHKKTKKDTDKDRKSKKTKTSKKEKQESKRGYEEAVGISTPSKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7M9</accession>
    <name>A0A194R7M9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_09813</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7M9"/>
    <dbReference type="STRING" id="76193.A0A194R7M9"/>
    <dbReference type="InParanoid" id="A0A194R7M9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAA5</accession>
    <name>A0A194RAA5_PAPMA</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
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        </source>
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    </feature>
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            <begin position="44"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9196" checksum="A217F45C7ACC2552" modified="2016-10-05" version="1">MASPSTTDTEEMELDSPLSPENPDDAGGLFTEVRNKKKRKKRSSPASSSASSVVPISRASEGAAPMSPARTRIFPAGSNPSPYGYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB91</accession>
    <name>A0A194RB91_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="22693" checksum="551E7A47FA18156A" modified="2016-10-05" version="1">MAPKKQKDASKSRANLADDEALEWLKPRVLIKPDDQDFVPESELDEEVGRILTTINPQWVPVEVAYHYGQNKFITKPKPAFGKAYPLYVYQGTAIRKDSDEAKAQIAAGYGMVGFDDAGPKRAKVKKAAAEEEEEEEPEAEPPPVEEAKPEEEGPAEEEVPEAAEPPPEPDVQDEQEVGNEEVEEPEPEESKIAYIFEQIFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCX4</accession>
    <name>A0A194RCX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dystrophin, isoforms A/C/F/G/H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09401</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RCX4"/>
    <dbReference type="InParanoid" id="A0A194RCX4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129963" checksum="2A02074D90D8C375" modified="2016-10-05" version="1">MNIAECRLDYNNPAIIRIDGKQRGGVRRGGGGAPAGRGGGARAGGGGGAAGGAGALRSQLEALRRELPAALQRLRAAHSRTERVFEEIEELERFLAELEGQMPGEAECAIRDSAELYRMKTRFQTLKEQCDERTERFRALNEEGADLCHVYLCIHFNSGPSSQLSRACVCAGNEILLLAERRAAALARRLTQLCALWSRVTHAVYERYKVLAEAWHESGELRAWLAQQAAWLDGLQRRLQHPRPSPDRPDLPDAEDISDQLYDLENYVQNHSDERLARIQDIGRQLERAHIMPDWIRAEVAAVTQRWHHLRDQAQERSRELEAAAREAAQCEVQLERLQQWAEGALGGRPGAGGRSGLRRELPARRAALLDLERRAGPQRLHDQLQRLQEKFDEIEEELKPGSGEPEDAEEEAGAGEDAEAEAGAGETEAEEGATRLEARLRRAAGVPQEVQRAAAALPPAAPAPPDPDAVRAQLRRCLKSYRTLSEIKSEVESIIKAGRKAVEERAVPEPHEFSKKIDGLKELYNKLGAQVTEAKSRLETALLTAREIQTDLQALAGWLDGLGAHPPAARQALELEMSRMQGLRDKLNANFAEFARCCDRAYLDSLAHQIDDVNSRWERLLRQGPPAPAEAEGAGAAGAADELRRLVREAQAQLEAAGGAGGGGEAERARLRVLRAELRARGAQVGAARDPQLTRLWEATLERLVALEAQREPRDGASPPRPDRYESVTDTIKRRLESPGDAPDSERPDLKRSRIPLALKSPMPIKKEVKEGGIRSRGSSLERRKQKEDSPMMVGDDASSMSADSVEVAARAEPAEPAEPAEPSTPSTPDASKKNSSTFNLLKDSDLFTQISNQETVAVEPRARDERSPDPYCVVEVREREIVKSTVSPVELKEIYPSEAIETVVEFIPQTVERVEIIDDTEVESICDSDGEEKRAESPPPSPAQSGTFVVEVKKFEERMKPTLGILKRQTGEDDNPRPIKVTMNIPDLISTIESKSEGDASVKSLPPTPPSEADPPPAKYLVLDDVPKDQAALPEPSATEETFANDKYDVVVRSGAASWAASGAASGEASEAIYSEVQAAPQARVASSSEFEDKEPLSTSTPIKNEESRQAQAQAQAQAQVVGVAHKSSPRATRPAPLASNSSPPSSPISFSKSYSPNCKDKATVVTNEKYQKTDEFEQVSFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD00</accession>
    <name>A0A194RD00_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor Dp-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD00"/>
    <dbReference type="FunCoup" id="A0A194RD00">
        <property type="interactions" value="1204"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD00"/>
    <dbReference type="KEGG" id="pmac:106710715"/>
    <dbReference type="InParanoid" id="A0A194RD00"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="10">
        <location>
            <begin position="269"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="460" mass="52253" checksum="698BE6027A23245A" modified="2016-10-05" version="1">MSQKPSIVKFLIHDANGQPQMVKVVQNSNNQTTAIPIKVKANPVKIYKLPTVAEGKINTQTPVFCPIKVTSGIKCASKLVPVPVETLTHLQKIVPKTEPLEVKVEIEPKEQYQDQILEQPIAQTVPNLVQILPKPESPPVKSNRKSSNLTSPMSHASRRRHDSDNDPPAEYTTKRRKHADKVGKGLRHFSMKVCEKVRNKGFTSYNEVADELVLEFTAGMHSSADTQQYDQKNIRRRVYDALNVLMAMNIISKEKKEIRWLGLPTNSAQECAALEKEKQTKLEQIQRKTQQLQELILQHISFKSLIERNKETEKKGIKPSPSSAIHLPFIVVNTSDKALIDCSISNDKTEYMFNFNKRFQIHDDIDILKRMGLLYGLEKGECSEEELRKVKSMVPKSLEVYVEQMGRAENCTLSNLLDEEEVDDENDDDDALEVEVKEEQEEEEEEDGNDYSGDSSDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF31</accession>
    <name>A0A194RF31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chondroitin proteoglycan-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF31"/>
    <dbReference type="STRING" id="76193.A0A194RF31"/>
    <dbReference type="InParanoid" id="A0A194RF31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF108">
        <property type="entry name" value="OBSTRACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="20337" checksum="771A33E977799BA0" modified="2016-10-05" version="1">MKENIVMQSEHICVVDDGLVPNLDPPIGTEHCDWLYGIFGHETSCTRYWTCWNGTATEQLCIGGLLYNENAHSCDWPENVDGCQKHPLCNEDPNGNVPLGKSCNRYWQCQGGYPRLQRCPAMLVFDRRSLRCVVPPTDECEIPTTTLSPQEEEENSRPGQQNKRPDYPDGQPGRQRARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIW0</accession>
    <name>A0A194RIW0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIW0"/>
    <dbReference type="STRING" id="76193.A0A194RIW0"/>
    <dbReference type="KEGG" id="pmac:106707859"/>
    <dbReference type="InParanoid" id="A0A194RIW0"/>
    <dbReference type="OrthoDB" id="6412801at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF13">
        <property type="entry name" value="FI04421P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265248" description="Bactericidal permeability-increasing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50850" checksum="F91AD4F892EC2137" modified="2016-10-05" version="1">MWKCCAILSVLLILAFGQDDIEVTTTDSKLVEGEKKMSDQILIILEHFKQPNPVGIPGAEVPDPYPVPDMKQSLSLGTLYFKNTAVYGISKFRILYVNAEIGAMEVNAALAIDKLQARGNYTLSTWLNRAQGPFTVDISGLKIMAKATLGVERDGKLQAQGITIDLGFSNIAVNFENLGFFGSMFQGIVNSVGTFLFDSIKPYVLKEAYTKARAAINEKLDEVAGDMQFPNSISPLDMVIADARKKVRQMDLDPYKVKDYNTTVSVFTITLDHTWIMGISSFQRVGNITLKLENNTVIADFEIGTQKLQGVTQWEISAISGLMSRAGTASFSVEYISGRLVLAQPLDTRKQPQFRDLDLEVGNIQVRFDGAGTLDYIVEFAVNVLPNLLRYQIMDAIEGPLKERLQQELNKVNVEEMIKQELPKIDDMQEKGFKLSALRVAEAQDEAYDEDDFFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ13</accession>
    <name>A0A194RJ13_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09977</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ13"/>
    <dbReference type="FunCoup" id="A0A194RJ13">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJ13"/>
    <dbReference type="KEGG" id="pmac:106709855"/>
    <dbReference type="InParanoid" id="A0A194RJ13"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="28342" checksum="AF833B92CEA0EFDE" modified="2016-10-05" version="1">MPQKLENGNMDLPDITEVLEETKQVIQKCFTQFQLDEVFFSFNGGKDCTVLLDVTIDVLKSMYKREDVGKDLKVIYIRTTGPFKELEKFVEEIETHYKIKLIVAEGDMKEVLRRIIESDKNLKACLMGTRRTDPYSEHLKFMQQTDEDWPQFLRVSPLLNWTYHQIWSYILQRRVPYCSLYDKGYTSIGSTSNTWPNQALAYSENGVVSYRPAWQLRDATLERAGRGKHYANGHAHDDIQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJP3</accession>
    <name>A0A194RJP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJP3"/>
    <dbReference type="STRING" id="76193.A0A194RJP3"/>
    <dbReference type="InParanoid" id="A0A194RJP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="597" mass="68654" checksum="1106D73BE0831DD2" modified="2016-10-05" version="1">MVECNRCGKVFKYESERKRHELSHLPGFECNKCGKKFTYRQVYLIILNNFCNSALKRHQKQHERTGTVKCDKCNHCFKDSVLLKRHMKYAHEGTHICKECEAQFSSHQALRVHMLTHKPKSERKYSCRYTDCNKTFNFSHHLKYHEMTHTNNRQHFCDVCGKEKGANEQREHQGVHRHGCVSALKRHQKQHERTATVKCDKCNHCFKDSVLLKRHMKYAHEGTHICKECEAQFSSHQALRVHMLTHKPKSERRYSCRYTDCNKTFNFSHHLKYHEMTHTNNRQHFCDVCGKGFIQSHNLKVHMKTHEASKRLLCEMPNCMKKFNSESARRRHYARHKKLPIDEEPTDNLVNAASSEGHPCSPCDQFVVPSFPEDHELSTERNINIDLSASQLKKTIEEYQVGIEDDLHEDMVDSMGCVNTCRSVLGKCLVTGDTSGNGNCLCDQMVKGNNNEDTKNLVKENKKLIDVIEKSNALNISCDGCACSNTDKIVENLKEVNNDCMPELEYVNGVIKIINTIDSDLEGFVDINTKPMSKSKCDSETIPYNSCKAILGTCIVSGNGTISEDCLCAKMLMDDQQMISQEMEEITPHPCDSTMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJU7</accession>
    <name>A0A194RJU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ryanodine receptor 44F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJU7"/>
    <dbReference type="STRING" id="76193.A0A194RJU7"/>
    <dbReference type="InParanoid" id="A0A194RJU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ryanodine receptor junctional solenoid" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor junctional solenoid" evidence="3">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RIH" evidence="2">
        <location>
            <begin position="231"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="383" mass="44129" checksum="6062DF6C0BF8F068" modified="2016-10-05" version="1">MQALADAVETNQVHNRDPVGGSNENLFLPLIKLVDRLLLVGMMRDEDVEKLLIMINPETWDPTFDKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDIQLRHRVESTIAFAHDFVGDLQTDQLRYKTKPGAFGKLYNIINTVKELEDEPKAIEEPPKKTPEEKFRKVLIQTIVNWAEESQIETPKLVREMFSLLVRQYDSIGELIRALEKTYVINAKTKLDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRVHENVMAVMMNTLGRRAQAQSDAQPANPPAADDTSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJZ1</accession>
    <name>A0A194RJZ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protease serine 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJZ1"/>
    <dbReference type="STRING" id="76193.A0A194RJZ1"/>
    <dbReference type="InParanoid" id="A0A194RJZ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265275" evidence="6">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="49"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="392"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="487" mass="53743" checksum="FEB841197DF10626" modified="2016-10-05" version="1">MGIIYWDGILIIITIVRHTSGDTWQEVANHSSWRKLEAFECGYSAADRIIGGLNAALGQFPWILRLGYTLEGEEDLDWMCGGVLVTDKHVVTAAHCVKTADDGIKLVSIRAGEYDARTDPDCQLGVCAPPLQDRRVRAIRSHASFNKPPFHNDIAVIELDSPFDLNDYVAPICLPQRDQLTELRLGELVTVAGWGKMNMSTDQRADILQFVSLPVLKPESCSFFGKGFKVEKSEICAGSQRNKDACGGDSGGPLMKISSNWLWLVVLVAGSFRTTLSMKYQCQQKNKECTIITNCTSALEALKSREDKLLRMMHCGYDVRGPRVCCPVDRPIVFRNDLETATSRVETTSTTQNPATTPLITTSTSASNVLNTANVLPSIKVCGISGSGLDRIIGGSIAALDEFPWLARIATKRYDKLKYTCGGSLITQQFVVSAAHCVIDRKVVAVRLGEWDTETEKDCNDDYCSDPPVDVMVVQVIVHPMYDKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKG1</accession>
    <name>A0A194RKG1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKG1"/>
    <dbReference type="InParanoid" id="A0A194RKG1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1720"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1748" mass="198651" checksum="80C95DA4733BD5AD" modified="2016-10-05" version="1">MRRGHAGIGGWRNENIRHFRSRGGGNQQFIPRDYQPLDVPRFPPPITRGFRPPLIASRLSHTTDNFPGNNRNKFRYMNRNNVNRTYDTHNERQMFQQPKHFTHSELTSPTKRNKDSNIYDNSNQSNACHINSHGDIDLRQPSGNTSRLGHKQPSFTPWAHPPEHKLHQYEERNQNRQYKYNEDLHKLPYPGHRPPSSDHYGGNPTSIIENSKTYSRTVDDTVDIIRKRILDRNESVHTSDNLNIDNSNNNSFLPEESFGHFYDAQQEQPIRRRIQRQKQKNKSNCDKIKNKIVHQLFKMDKEKIHKLMDNPNSSSKFEYAISSLITESQNSYNRHLRSVAEKSLCGSSTEFIQDDHNTIYEDTFLKQMQCILDPQDTVFLEDIKPFVMAELSKVLQLEDFEQQHIDSESSSHLNNEQFGYDEYPSSSSKYENYLHEYEDQGISNFQKSEIQRMNRKISKNYDVNVRRNNTTFKPNFEPRQRAKSCSYNEDRGPVTENVRFARHSLDNKSNDTFKVEEVPVFDPNSKSLSEDEDPFAELDNQYHVAVDPNFIADDTSSSHHSQRDSSVQPLFDNSYSSSGENYNIDNVKQEIDSQILNIAKSPLKLHAKNNDKGDINERENINSNIYQNTDKQSGSSTDYLHTVNSFTVDDICVPGDNHVSTESKTSHTSSTSKSIPSSNSRKRPIDQQSSHRKEKRKKSEDGPPDPKKKKDNRNITNVPAKIGEAQIKTGKNVHKTKFLPNKAERIKFSEKEYSNKYVKRKSKNKHEKHSHGSRKKNASTPSSHSNLPVTNSNATITPPKTDPKNTLKTIDMFTQKPKKVIIHQAHRNTAVVPSTKFASSSEKDERKKKDVTSKIFQRDAATQVHIELVSKDTQTNEDIICARCCLSEDTRLVEKLEMDPTHIAIEPVQALNPLARMKEIDLQIQNLVEEKLKLYRSLGMNEPSEDSLQSLGIAILNMPEEENKDENVEKDCLGFNEIIEEVVDIPMNDLVELTSENTKEVYIEPHNETIDTTNNTIDAPKGRKLTRRQMILQERKKSAGPRSTKKVKKDKSPNISLIEQILKDDRPLEEIITLDDFEKPMRTRRKSQRVQRTKKKIIKTAKPPIDLNDLNIIEIRECSVVLVREDLNKLLAEYNTRHFEHEVIQYEPLECASFVEAVEIPDKENSDIQLDMLDVSEDIIIDNNYEGKSAQDKELGLAEDSISEEIMLGDSQSSEDSLIPISSGENECKTFDFAADENLRRDSVCVTGQADAVLAIECIDNNFVAACLDGNVYYFSGDGQLINTLKGSNLAVTCLTIVKDKYETTIYTGSLDSRIRYYDLETGIEKGPECNVLSPIQTMDRAWDTVFVGTRTGFVLQFECKNNMLIPVSTVKFSDQSILALRAMKEGPRKVLLVASRSENVTIKDAQTGLLLRTLEGPKMTVYTLLYEDGKVYCGTSNHQIQVFDYTSGSHVGVHEGGKGAVCLRACGGLLFAGCYDGCVYVYREGEPRPLAQIRGPGLMLLSLAILGTKIIAGFKDRSLCIWKIPLIEIYLYCDNESGIVSINFFLFVLFDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTVELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDCTDQDSFSNVKQWLEEIDRYACDNVNKLLVGNKCDLTTKKVVDYTTANQYAEQLGIPFLETSAKNSTNVEQAFMTMAAEIKARVGPPSAGAPPGAAVKIDQGRPVDTGKSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN52</accession>
    <name>A0A194RN52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN52"/>
    <dbReference type="InParanoid" id="A0A194RN52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="13420" checksum="2C6955ED4435B62D" modified="2016-10-05" version="1" fragment="single">VGVGGVARGVGVPVPPPSDLLATISMFEQQIKAEPMSFYTPHSHHSGPPTIIRSDSNHGVINMNQHHHQEDSKDSLIIQQQVQHQEMLEQHQQQQDLQAQDDEASVIGYGAIHDRTEDIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ80</accession>
    <name>A0A194RQ80_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ80"/>
    <dbReference type="InParanoid" id="A0A194RQ80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="17314" checksum="3F5FEFA8790FEB72" modified="2016-10-05" version="1">MLKVYSKIHKFSEVISYFCTREITFCNRRTRHLWDTTSQLDRQVTKQYQNPEAARTLLLQGNLSNCSNRRTIVRCNVCVFVCQLFPFSMAEVDWDEYFDDYLLGIRRYLFKQTDDSLPRARIKWKRYRNLSPCIFIFVDISSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ90</accession>
    <name>A0A194RQ90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ90"/>
    <dbReference type="FunCoup" id="A0A194RQ90">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RQ90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF67">
        <property type="entry name" value="RE68569P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="697" mass="79804" checksum="99D7C19445C60FE9" modified="2016-10-05" version="1">MSMGIRNTADALPAHNKGLFLFLMLGFFSLGAACFILFLRPYDFFMQRQPLLSCLFLFLMLGFFSLGAACFILFLRPYDFFFSQKAILEDGGEIFEMWRKPEVKLYCRVYLFNVTNAEEYMAGKHHKLKLQEVGPYVYRERLEHEVLQFNENGTLSAIPRHPLAWEEELSEGNREDDIVYMPHIALLSIANVVSKQSFVTRFGLNNLISLTNTRPLARMTAREFMMGYSSELMTLGNTFMPGWIYFDKLGLIDRMYDFDGDYETIFTGTDDVTNSGLIDTYRGSTQLPQWEGRHCSNVQFASDGTKFKSGVGTNQSILFYRKSLCRAAPLIPVAEGTKGGLKGYMYTFPEHMLDNGKNIKENKCFCRKGKCLPEGLIDVTDCYYGFPIALSYPHFYKGDDILFSKVEGLKPNKEDHETRFWIQPDSGLPLDVSSKFQINMALDDISMITNTEGFSNMYLPMLWFDIRMFSLTPSLEQRFNLYLNVLPIVEKCAMYFCFIIGAALILITTYILTFKIMFKNYNNNRNRKCNFNFKTNLWFNQEKTNNKKARGDSVYAPCEIPLNDTESDNSDPQLDDKKQSFIKTHGDKIKELGNKLSGKVHDSVGNVTGTIKDELSQVKKAINERKSSLISPEAERSDSGEENYSHYKPVNQSDSDEDCKYLEVVDDGCEFDDSSVVFSRDTRTASAHNNQLYINIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQB1</accession>
    <name>A0A194RQB1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQB1"/>
    <dbReference type="InParanoid" id="A0A194RQB1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33584" checksum="D6521900F91D1AEF" modified="2016-10-05" version="1">MEEVHYKPFHKTYRLATYAMIIAAIYPNPEKRKIRWFYGMMVAVSAAPFAIFIMIAIYRFWMVGDVVNVIKQSTVGGPFLGGFLKVIMMNYHEERALSLIDEMNADYAMYSRLPAHHRAIVAEGIRTSRVYAERGYIAFISFCVLNFPFLASVMNAYIFLAKSESPKYFAHDVAIPFLEPDAVFISPYFEIMTVYTAYCAFLYLVNFMGYDAFFGLCINHACLKMRLFCAAMEDAMKAPTREQMRKRVSLVIQSQCSAFRYKLRLLIPPLSTRHLKITKPEDYPYINTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQK5</accession>
    <name>A0A194RQK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysosomal alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQK5"/>
    <dbReference type="InParanoid" id="A0A194RQK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1204"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1350"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1409" mass="163834" checksum="E9454CDAC103D437" modified="2016-10-05" version="1">MDAGWVKTYDEYYYGTRTSVSTANVQLIYHSVLSELLHDKRRKFTFSETVYFWRWWKEQRPATRATFRALVAEGRVEFAGGGWVQNDEATTDYLQIIDQYTWGLRKLNDTLGPCGKPKAAWQVDTYGHTREQASLLAQMGYDGLFIGRVDHKERESMIEEDRMEFMWRGSNVLGKMSDIMTHNLFNLYNAPDGFCFDFLCSDEPIIDDPDSHVYNADARVNDFIAQIERQAKYYDHDNIMVTMGGDFTYQSAANWFMNIDKLINHVTTHPANLSDVNVFYSTPSCYLKAIYMYGRRDKSVFTEKVAKPNSRTDQPVWPDIWVERPDMTSDYLPYGSDSTTYWTGLYTSRPSLKYLARKSHIFLQVVKQLTVISCMGDSYELHLLRHAVSLLLHHDAITGTSQQHVTLDFIRTLTDAVESCSKKVSQYLSSLTPTWGGSRRSKNNQQFIICHQLNMSQCRFSESQDTMLLLVYNPSSIKTYFHVRLPAIAMHYSIRDYNDEEVEYQLIPLPASVINLPGRSSSAIQELCFEAENIPPLGYTAYYLAPIRDPLEESSFVKKTHHGPEADQELTPNISNEYLKVTIDKETGLLESIQHVDGVKVQISQNFYYYSQVQQPLQSGAYSFRPSRNRPTPVSITYMLTLPTRPQEKVIYHAVRGSLIKEIRQRFSDWVTQVIRLYRGEEFIELEWIIGPIPVGNDLGKEVVSILKTNISNGGEFYTDANSRQMMKRNCWNESTSHQVKKPVAACYYPVTSRICLRANNASVELCVLTDRAQGGTSYSEGEIELMVHRRLLTDDGFGLEETLNEEAYGVGLVVKGKHRIMFGNYRQEMDEQTFSERVSYTARKWLMEPWLFLAPGEKINRRKWQNVRNKRYSAVRLHGLPRHIHVITLEPWKAGSVLLRLENTLENSDKEIFKMEKDTTDESPRTTHIVVDLRKIFGQHEVRMVRETTLAANQWLEEARQMDWSTRYVYSGGDDGILPEDNVDYTDDKLDRTERKDSEFTQEDTYFVRKQPRKKINVTPKQKTYKSRYKYDERRKRSLNITENMIETVNEANASDSNAFITQVETTTKPYKETTSYDEVETKNNSIIPTDFRHIAFAPKPDLSGDLLRTRFRADSKKSPKINYNHSRVKPMKFFVEWGNCSEEVGSTEDENFSSNLKKRSARRRNGSHSVKTNRRNGDFFSNEPDDGITRSMYEMYYKIKPANNLKPRPEPQTPAPRRFKKIKGKKIRIDKHEELSRIERTTRKSRRNRNKRKGKTYATTSIPLEIYNTKKRITREKQRQNADSGQDNDSEAENTKTFSQLRKAQFTHMAPKTELAHLRAKRRKEAMRSYLDYEADTSDGAEEESREEGDKWENTRRKRTVSKEEEMAESSSDSQESNESEFVVTLRPSQIRTFVIWFVDNRKTYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQL2</accession>
    <name>A0A194RQL2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQL2"/>
    <dbReference type="STRING" id="76193.A0A194RQL2"/>
    <dbReference type="InParanoid" id="A0A194RQL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039932">
        <property type="entry name" value="Spink4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179:SF0">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="476"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="599" mass="67594" checksum="74A2CD1009C40222" modified="2016-10-05" version="1">MGRSGDAQEGAFLTTEVFGLNLRNKRQAETNNNDLEDRYGFMLPSWYPTRLPPQLPMPDRRFPGQRPNFGQYPDQGFYPDPSLYPGLGMYPYPGPFPNPGMFPNPQPFPNPQTTTPAASDPNVDDCITNCPVTAEYNPVCGTNNVTYPNPGRLYCAQACGITFLTTEVFGLNLRNKRQAETNNNDLEDRYGFMLPSWYPTRLPPQLPMPDRRFPGQRPNFGRYPDQGFYPDPSLYPGLGMYPYPGPFPNPGMFPNPQPFPNPQTTTPAASDPTVDDCITNCPVTAEYNPVCGTNNVTYPNPGRLYCAQACGIIISLFLRPKADGKSWYRYDPSDRYDDRIIFEDNRDTRYRDNDFGELGQHDSHNGVGQKHPRDWNPDRVWFPDSGYEDRGITTKSTTDLPRQVTTISSREYYDECIKGCPTTSEYNPVCGTNRITYSNIGHLECARFCGLDVNLYRKLPCFTTETTIYPTTTTESDSQRRCIASCPTTPEYNPICGTNNVTYQNMGKLECAKICGIDVELKRLSPCPKPITTPPPNGDDFFNSVDQSSWSSNTDNNVFRPTTKAPHTTFTISQDILNNVFNVPTPDPSDYDFDVRFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RU78</accession>
    <name>A0A194RU78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RU78"/>
    <dbReference type="KEGG" id="pmac:106715833"/>
    <dbReference type="InParanoid" id="A0A194RU78"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="584" mass="65821" checksum="B5D115DE92AAD15F" modified="2016-10-05" version="1">MESHEKENKFRSAIDNAAFEMTSDVSSAKETAGPRRLKDLDDLFPYIGDFGWYQRILFILMIPFGFFFAFVYFSQIFMTIVPEQHWCRVPELSNLTVEERKHLSIPLLEDNKYDRCHVYDVDWQKILEKGVTEPDRSWPIKKCQEQWEFNFTDVPYETIATQLGWVCDKDNYPATAQSVFFCGAIVGGLLFGWIADKYGRIPALVGTNMTGFFAGVGTAFSNSFWSFCLCRFLVGLAYDNCFVIMYIVVVEYVGPKWRTFVANMSIAVYFTFAACLLPWIALAVADWKIYTLITSVPLVLSIFTPCVVPESARWLISQGRFDEAIKILKKFERVNGKKIPEGVLKEFKETASEIARSEQEVKNYSVLDLFRTPRMRRNSILLLFIWMSIAMAFDGHVRNVGSLGLDIFLTFTVATATEFPADVLLILTMDIVGRRWLAFGSMVISGIFSLLATTVPLGIPSASLAIVGRFSVNISFNIGMQYAAELLPTVVRAQGLALIHMTGYIATILVPYIVYMATIATEIPLLILGTIAIAGGCLCMCLPESTGKNMPQTLQDGEDYGRGQKFWDMPCFNRKAKRGNADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAW9</accession>
    <name>A0A0N0PAW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Patj-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461146">
        <property type="protein sequence ID" value="KPJ08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAW9"/>
    <dbReference type="STRING" id="76193.A0A0N0PAW9"/>
    <dbReference type="InParanoid" id="A0A0N0PAW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06667">
        <property type="entry name" value="PDZ2_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="486"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126460" checksum="65EAA240E7DEA55C" modified="2015-12-09" version="1">MVAKGDTVYANVYLVVVIQQVFGEWAQVEVVELVNDGSGLAFGIVGGRSSGVVVKSVLPGGVADRKNVPTGEIPRPYRRQALCGGDTAEVLLYERCYPQDGRLRSGDMLLRIGAVSVVGMCARQAAAVLRQCGACVRLLVARPASAALPPSMQEVRALKGLIQSIKTVRNMARERFFRGVLSGGIHSGGGAAGSTRPRPAPPATHNRTQPVASIVAVVPRGALAPAPRPPPLIIAPPEPQPPPMRLPLDMAVRGGREPETLSYEVQLNKHSALGLGITVAGYVCEQEELSGIFVKSVSAGSAADLCGKIQVNDRIVEVDGVSLHGVTNHKAVSLLRDAKGPIVRLKALSFLANHKAVSLLRDAKGPIVRLKALRYLRGAGFEKLQKALAAQDGRRSPVAPPSPSVTSLAKYSFSVYDESTVIEAEAESEIRHLPSPTSPGEEAEIVIGREDDISERELRRIQDKWRDILREEKDWPGHQHQYDIVVGTIMKEKDSGLGISLEGTVRVVGGKEVQARHYIRAIAPNGPVAKLGTYKVGDELLEVNGWRVLGSHHVEVVTRLRAVTSPVLLVCVRKRQEENKERENSFSKSAIIGGSLQDLLIPPQRLIKAKSESSVASLCSAATVMSAGHDHDEDVSCWVISLSINRSNRNKILLDRLIECVNSIASDDHTGMDSFHECLQEYGEGLEVVQICLEPEEASIKDDELSALCDLSFDECKRNQKESICKDQLDKEKVNGITELKSSKSEESLDEPDDDMTITEDDVLVSPRELNIRSKSADRKEANGSRSLSKQNSKDLSTSDEMVFAVTPTGLERISFEKYWKDCGENKEEVLEKVKSDESWKECLNSPTDEASSFYDATTRISVQEENNTLLYIDHEIDGYETCLDDDSSSVKCAEKNGYKINGDREIKDFSKQNEVHRNKDNDACAKTNTDQNIVDVVDDSSYTRPYVQEHIIKQMKSLRIEPLNVNISTKKIRKKSPTKPSKNERRCIEYYNDQDECLKEIRMKKLEEEKRHKEERKRTPKKTIAIEKKMMLKKQEPSEESTDLENNYVPDCHKCFLENYAYAITKAYIAEATACKFCEVIREMLEPPKRIPDRRMSAPASISWESGSESEEECLLAVPVVKDRRKSAGPLTILTSPRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAY5</accession>
    <name>A0A0N0PAY5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="9"/>
    <dbReference type="EMBL" id="KQ461113">
        <property type="protein sequence ID" value="KPJ08911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAY5"/>
    <dbReference type="FunCoup" id="A0A0N0PAY5">
        <property type="interactions" value="989"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAY5"/>
    <dbReference type="InParanoid" id="A0A0N0PAY5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="360"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="507" mass="54404" checksum="8E2555F25BB9915B" modified="2015-12-09" version="1">MASKVAKSLLKVSSPSSTVKFDTARRALSVNAALQQKKTLPDRTGKNVVLVDGVRTPFLVSFTDYAKMMPHELARHSLLGLLQKTGVSKDVIDYIVYGTVIQEVKTSNIGREAALAAGFSDRTPAHTVTMACISSNQAITTGVGMIAAGAYDVIVAGGVEFMSDVPIRHSRKMRSLLLRLNRAKTPAQRLSLIASIRPDFFAPELPAVAEFSSGETMGHSADRLAAAFGASRAEQDEYALRSHTLAANARDKGYFTDLIPVKVEGKDGVLDKDNGIRVSTPEQLILTIAKSVVTTFLEGKDGVLDKDNGIRVSTPEQLQKLKPAFIKPHGTVTAANASFLTDGASACLIMSEAKAKELGLKPKAYVRDFTYVAQDPVDQLLLGPAYGIPTILDKAGLKMSDIDTWEIHEAFAGQILANLKALDSDWFAQNYLGRQTKVGNPDLKKWNAWGGSLSIGHPFAATGVRLAMHTAHRLVREDGQLGLISACAAGGQGVAMLLERHPDAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBJ1</accession>
    <name>A0A0N0PBJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0172 protein CG3501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460971">
        <property type="protein sequence ID" value="KPJ10136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBJ1"/>
    <dbReference type="FunCoup" id="A0A0N0PBJ1">
        <property type="interactions" value="1680"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBJ1"/>
    <dbReference type="KEGG" id="pmac:106716109"/>
    <dbReference type="InParanoid" id="A0A0N0PBJ1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="25342" checksum="11824C7A27038DBF" modified="2015-12-09" version="1">MGEVTLETIAYAKLMLHAAKYPSCAVTGILLADGTNIRDGAKNQDLNIVDAIPLFHHSHYLSPMAEIALTQIDTMAQADNRVIAGYYAACENFRDNTVEKCPGQKIAEKIAELFPSAVFIVIDNKKVMKHLDSPAIKVHSYNEGKWKPKETSNILYQQSYVLETVSYLLQALVYKDLVDFDNYLDDLTLDWTNLGIEKVIASINASNSIEREYIEERVSDKENDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBK0</accession>
    <name>A0A0N0PBK0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBK0"/>
    <dbReference type="InParanoid" id="A0A0N0PBK0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1689" mass="192423" checksum="D3EDDDCFC69AD44E" modified="2015-12-09" version="1">MFENIYYKTLAQAQSFIRNDAVKNENASKVHNSNIKLPTIVMPTFNGQYDQWLEFRDTFLSLVHNSRDISNIQKFHYLKSSLKGSAELVIDSLEFSSNNYEVAWDLLLNRYDNHKLLIFNHVKSLFNLKAVCNESSSLIRNLIDTVLKNLRALKILGEPTDSWDTLIIYLVASKLDVTSEREWEHYKVNLFTNTADKRSSVKLDHLIRFLGDRADMLDTLSASHKRQHYNPNKLSSTQIKSKVHCNVLSEKPRSHDYNAKNCLACNANHPLYSCEKFLNFDLNSKLSFIKHNSLCVNCLRAGHTLANCRFGPCKKCNKKHNTLIHNDYSNTATSHFSQLHSTKMATCSAPAPVSAGDGYVGNESSHSIQVNEAHINSNLQCARSIKPVLLSTALIEVADVHDNYITARALLDNGSQRCFITKSLCDSLNVPVVQSTMEIRGVGNSVTQTTEVCEIDIKSRADPSFATRLNCFVLRNITSSLPAVSNLCAQLPKEIQLADPHLYESRDVDILIGADKFWDLLKSKLIRLPAGPVLYDTHLGWIISGQVNMRNTLRGDSIYCNLTQSLEMQLRRFWELEELPKTGADTRTDEERACEEHFVGTTRRKVDGRFCVRIPFKGSPDRLGDTYSIAERRFKALERRLERNTNYKAQYVKFMKEYADLGHMSLVRNYGTPHYFMPHHGVFREHSTTTKLRVVFDASAASTTNVSLNELQMIGPPIQGDLMAILLRFRQYKYTACADIEKMYRQCLVDETQRDLQLILWRDDPSKPLDVYRLNTVTYGTASAPFLSCRSLKQLGYDCADPDVKRIIMEDFYVDDMITGHDDKFQLLQICEHITEVLHSGCFPLRKWLFNFDCNNAEFLDSKTSHLTSKPFHLEENVNAKTLGLGWCNIRDTFYFATQFNNTSQKITKRYIMSIISQIFDPLGLLSCVTITVKVLLQRLWLLQIDWDDEVPSDIRHTWQAFVSALPTLRTLRIPRHAIGDNPIYVELHVFSDASESAYGACVFVRTVNADSTVACNLLCSKSKVAPLKSVSIPRLELCGALLGARLCEKVRDSLRCHISKVIFWCDSTIVLGWLRMAPNALKPFVQNRVAEIHDLTKESLWRHVRSKENPADMVSRGVRLEDLPSCTNWWHGPTFLRDVEFDSTTVDGTSEPQILTESLPELRPKPAHSLIVETSFPNSLFPFHRFSLHNRMRRAAAYVLRFIHNTRHKRSRMTGNVSVDELRRADTMLVRFSQLESFPSEYSIISNDKQLKGKHNLAKLNLFIDNQGVLRVGGRLTNSREFSFDKKHPILISSKHLFSLLLFRHEHKQLRHAGPQALLYTVRETYWPLGGRSLARQIVHSCVTCRRFRGKTITPIMGDLPEERITLAFPFYRCGVDYAGPFLILNRKGRGSKLVKCYICLFVCFVTRAVHLELVGDLSTDAYLLALKRFIARRGKPAEILSDNGRNFVGLMTEFSKFINNCSSHIIDYATSNNIKFKFIPPYSPHFGGLWEAGVKSCKHHLVRSLGKAHLTFEEFSTVLTQIEAILNSRPLSPLSTDPTDYLPLSPAHFLVGRPLTAPASEDFNDTPALKLNRYQRLEQIRQQFWTRWAKEYISELQTRNKWRHNQSSLQPNTLVVIKDDNTPPLRWALGRIEATYPGKDGVSRVADIRTASGVTRRAFSKICPLLDDLTASSLEAGASKAGGMLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBX2</accession>
    <name>A0A0N0PBX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox protein HMX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_01301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460777">
        <property type="protein sequence ID" value="KPJ12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBX2"/>
    <dbReference type="STRING" id="76193.A0A0N0PBX2"/>
    <dbReference type="InParanoid" id="A0A0N0PBX2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857351" evidence="12">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="325" mass="35953" checksum="05FF448726B9A841" modified="2015-12-09" version="1">MKIYFLALFLHVVTISKAGNAFAIPLVLQMSMGVDEHLGVPAAHWVLSLNGAHSPDVTAAWCPRPGTGNDRTNGPRHEISHGNIVGMMSAWQGDRGDRATHWYGLAAKLIDSEDSTTNEEGSAGGSPRPRSPPRAPSPPSPSRSSPRSPRLHPALYPQQQDPQDSDPDVDESDDFDKDEKRDPNANLGKRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANMAHAAQRLVRVPILYHESRPTMPHTPLPIHPQFSNEPGVYFPPQAPQPLQPLPASPVTSRAPLSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCG9</accession>
    <name>A0A0N0PCG9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCG9"/>
    <dbReference type="KEGG" id="pmac:106712965"/>
    <dbReference type="InParanoid" id="A0A0N0PCG9"/>
    <dbReference type="OrthoDB" id="7474945at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33633" checksum="33D83FCBDBB821B3" modified="2015-12-09" version="1">MESPRRSASVSPSRKSARPIYRSSAVSDLIKSEDYEDSNNLISSIPEREWRLLTALAKKREENAERDRLADEFHKMWREEKREREMIEAQTSEQFKQYIKEKRRRERCMGELVQGRRRLQQHALQGQLLECIRYKDHRAKELMAFHDDRKVSRIIDNALEEESRAYLAADRRSRQHAAEHCRRSVQLIHALHREEKANKRRNALLRDTSQRVAISNALSSWESSLLRQEVAAEDAYKRAHTMARAAQTDARAARLARERDVRAHRARRLADFTERLRDAIKIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCU4</accession>
    <name>A0A0N0PCU4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">RR48_01434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460555">
        <property type="protein sequence ID" value="KPJ14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCU4"/>
    <dbReference type="FunCoup" id="A0A0N0PCU4">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCU4"/>
    <dbReference type="KEGG" id="pmac:106711941"/>
    <dbReference type="InParanoid" id="A0A0N0PCU4"/>
    <dbReference type="OMA" id="RGAFGNR"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="139" mass="15555" checksum="3A764F9B0EB84327" modified="2015-12-09" version="1">MLPLSLLRTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEVIDMVKEESQIKARGRNEVSKGRGGQNMRSGRGGGRGAFGNRGRPAPLARGGGNTGRNPQNKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCV2</accession>
    <name>A0A0N0PCV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCV2"/>
    <dbReference type="InParanoid" id="A0A0N0PCV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="16461" checksum="25DE3E6AC95641E1" modified="2015-12-09" version="1">MMMLLAQKNKALREKFKESKQLQRNIKTIDPDFFPTSDSDDDPAFSRFNSADQLLAPILPSSNGFDFEDSHFLSGPCTSNVDYFAMHQDDQNTEIGNNNKSPNSQPAPPPPQEKPRQPKDKKEKPNFPRPKNRTQKTIPSTNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDV2</accession>
    <name>A0A0N0PDV2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDV2"/>
    <dbReference type="FunCoup" id="A0A0N0PDV2">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDV2"/>
    <dbReference type="InParanoid" id="A0A0N0PDV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="95" mass="11513" checksum="C4CB8C13877D550C" modified="2015-12-09" version="1">MKHLSNRIFGEVATPTNSKSMKVVKIFSARPLHTNEEIIHYYPRHVETGKLMMKLRSYGLFRDEHQDFKEEMKRLRELRGKVKVWRRLQNKEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEF9</accession>
    <name>A0A0N0PEF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459785">
        <property type="protein sequence ID" value="KPJ19924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEF9"/>
    <dbReference type="KEGG" id="pmac:106712414"/>
    <dbReference type="InParanoid" id="A0A0N0PEF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="94" mass="10767" checksum="290E63B8C163D83C" modified="2015-12-09" version="1">MAIAFNLPSEREATEENFSRLNRLLAELYEVLCHILVARQPGQEVQENRRGECPREPNIPPYHLRCNSTYIVNLVMVVAILKVSLASSLFNTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEM3</accession>
    <name>A0A0N0PEM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459736">
        <property type="protein sequence ID" value="KPJ20209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEM3"/>
    <dbReference type="InParanoid" id="A0A0N0PEM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="429" mass="48523" checksum="FC8D1B567E7E5B2C" modified="2015-12-09" version="1">MGPKLVGAVAGRSHRQTYIICPYTPGGEDVQAGSVLLPATRRGRYLANIVRRQAVINAEAKKKVDVLSEELLPYIIAEQERRTTLYRRIMTAIQNGEKGVTIAEIRNKPPLIIRKGLMYRCPANRAPKEPDGTGILMCEDEIEPAQVMYDSCLSAEDKDLYVAENKYFFCNRHKIEGPDLPRNGSTVIGCAPIERTSLNYTSAKCALEDTDDVVVHYRYYPDRTYKFVTELDPDHEVCDHWNPCQIGYIYSLPSPDQAVQANELWQDSLEEWVPPTARNYTSSARKIIIPDGYEFHRIKHSNLLRNSGTSVLPAKYYTANVSGNTVTITLNFPTWSNTHVGPFFASFIKPGTKREKVLKFLTLCVTVQFQTVSPPPLGQQFEQEISYVCDDCTVSKVRDKPSSDHTSALCEFQLALTRWINRRPHPTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFA0</accession>
    <name>A0A0N0PFA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01012868">
        <property type="protein sequence ID" value="KPJ20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFA0"/>
    <dbReference type="STRING" id="76193.A0A0N0PFA0"/>
    <dbReference type="InParanoid" id="A0A0N0PFA0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="25082" checksum="258E4A6E6849F457" modified="2015-12-09" version="1">MSIASINTNVYFFTENVLVVPLKTRVNGYLETIQQKVVSHQSYLTQKQELKDAKEVIDVLKQKVEHLDSLVKLKNERIEDLQKQLERKQTRRKEVDALQNNLQVPYDVSTPPSPKEDDILLPVKLSSTKLVDNKNYRLEESKIPISKDLAKSTSRVCSVSLEDNVESNLRIDKIKLDDFKEIEIIEMTGKDIQDVDEFKDSVGEIILGAESRDTNEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFY9</accession>
    <name>A0A0N0PFY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044198">
        <property type="protein sequence ID" value="KPJ21412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFY9"/>
    <dbReference type="STRING" id="76193.A0A0N0PFY9"/>
    <dbReference type="InParanoid" id="A0A0N0PFY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="16013" checksum="B95B9827B4EFD29E" modified="2015-12-09" version="1" fragment="single">LNNTDTDVSSKEVFEDVLKQLQALGDRGKKVLYNLHKTMGVDYQEKQALNRSLIMSKVTGSEDELDRLRKVLVEAIDEEKNKTQRQQRRRDTREEARARRDLMLGQIELKKELNEDDEARNTAQEDLEEVYLYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I538</accession>
    <name>A0A0N1I538_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I538"/>
    <dbReference type="InParanoid" id="A0A0N1I538"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="27972" checksum="2D5FEB8085B30B0B" modified="2015-12-09" version="1">MNQQTDSQIILTPPEEETFDGIEVIEEPWTQDAQPPEDTIPIPEEYPSPSGENPRSPSPNQIPPSQPCNAPKKRPSSLQLRQTPSKRQQQEQKQEAQQEAKRLAKKQMRTTNWIVQWAKENITPTEINCLLGKSSLVIKELEESIITSFTSPPQKTGGITASLEKLLDPKNTNVLKLHVFSACLSILLPALIVQHLSKFSPSVTKKWQCASLIHWELILNKQRVTVQVPKGRARTARLSPRIWISQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I543</accession>
    <name>A0A0N1I543_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I543"/>
    <dbReference type="STRING" id="76193.A0A0N1I543"/>
    <dbReference type="KEGG" id="pmac:106718279"/>
    <dbReference type="InParanoid" id="A0A0N1I543"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="18366" checksum="D4B35A1802A8D288" modified="2015-12-09" version="1">MDNKPSLSQYFSSTEVPPASQFFDEIGTSPSEMIQSVYLGENEANTNKTPNIFSQNVTTSFAQTKVTQELTFGNVLPTVSGSTPIPATSLPDPSTFFDTIGPEPQLGSSKSAIAAPPALITEAIDGLSIKNQPVDKEADRRRDAWIPSEEAAKTLLKVILNYKNLCLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Papilio machaon</name>
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            <taxon>Insecta</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myosin_RLC"/>
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        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="262" mass="28754" checksum="23188DD6F0B0588D" modified="2015-12-09" version="1">MSRKAAAELASGPNSSDADSYAGYRIDLTIYGMVDRHSDEKSGEGMGEAWTSRRERNLGVRADKDKKVKKKKAPKEEAPAEEAPAPAAPAGDRQSSRGSRKAKRTGSNVFSMFSQKQVAEFKEAFQLMDHDKDGIIGKNDLRATFDSLGRLATEKELDDMVSEASGPINFTQLLTLFANRMSGGSDDDDVVINAFKTFDTEGKIDSERLRHALMTWGDKFSADEVDEAYDQMEIDDKGFIDTQKLITMLTASAEEEEGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDY7</accession>
    <name>A0A0N1IDY7_PAPMA</name>
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        <submittedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 29</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">RR48_05827</name>
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    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461033">
        <property type="protein sequence ID" value="KPJ09964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A0N1IDY7"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="41528" checksum="55A807184E57A3C5" modified="2015-12-09" version="1">MMNTEDKCAACLSELKDTSAMYCTCCKDKFHLLCLNLSQKEYNALTEDSIAKWTCDMCRSKGRKGGDKTNTPVRVRTSSPQLNFVTQRNKSRPAPNPSNPTSIAKAPMVSLQHSYTQYWQVRGARLKESRTDVQFHLAALRGDRARLCQLLDTGKVHIDSRDRDGTTPLILSAAMGHTDCVEELLAQGADPACCRTTGTSALFFAAQGGFLDIARLLLDAGADIDAPSTDGGTPLFVACQCGHLPVVEELLQRGANVNSCMKDGATPLFIAAQNGHEEVCARLLRAGAAVDAARADRATPLWIAAQCGHQRVARVLLEHGARVDATRQVPAVSNNTPATLFLYNSLISPRVVHRTRDSAVQGGAQGTRHPKQRCAPAPRHSGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFD1</accession>
    <name>A0A0N1IFD1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFD1"/>
    <dbReference type="InParanoid" id="A0A0N1IFD1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873919" evidence="2">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="288" mass="32313" checksum="367AE8F35EC36060" modified="2015-12-09" version="1">MAAKCLIILTIVSLLGVVFARELKLTSKLKVDPGIFISLETLRRLEAKAKNNGTEGSVITNTTPADDLGNVDDSIEIDITTTSTPDNENNPISRDPNDPDVANETISHDTGENQTKKPLDSNETETDGSIDEPVTSIPNISETTKNPDTSQQRYPTKATSQQALLAYQKIQWPVPQYPYGPEQNYYQPNPYQQLSFGAVSNQQNLGYNQMHPVLFNQQLLYNYNDPQPFSVNPQASFDPNQHHQQTFIVQHPYPVLNQQSNPQMNLISLNPISMPLPYQQMYQPVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGW1</accession>
    <name>A0A0N1IGW1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ459837">
        <property type="protein sequence ID" value="KPJ19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGW1"/>
    <dbReference type="ESTHER" id="papma-a0a0n1igw1">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IGW1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012090945" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="534" mass="60529" checksum="F4DCD7A4C067034B" modified="2015-12-09" version="1">MKVLVYLLVITGAWASPRLDPLVDSKKGLIRGLQATDGDYAMFLGIPYAMVNYTNPFGAALPYPDFEGTFEAYDDSAICVQNLQRTDQAIGSLDCLHLNIYVPNKASTSNKLPVIFWIHGGIFVHGNGGRTQFGAKYLVKKDVILVTINYRVGLYGFMCLDTPEVPGNQGLKDQVAALRWIKENIEAFGGDPNKVTISGASAGGVSVDYHLLTKTERLFDKVISQSGTSLCPWGVMESDRNVPIRIATHLGYVADDINEAVQYLATIDPKVVVTAAFDLSITCVPCVEKEFDGVENFITEHPMNYDIPKAKNTPILIGYTNMEKLFEFYNKPADKYNEREIFEDNLALAFHTIDDDQVKLVRQFYIGDEPVSENVKYELTDYDSDFTFIHPIHRRLSSYLDNNGTVYHYVFRYSGDRNFGKMKDNIIYPGAIHSDEYGYLFNMAVLTDIPTVEDQVTIDRMTTMWSNFAKYGDPTPEISELLPIKWMPITKGALNYLEIDKELTMKKRSYHARMAFWDLYYQTNKKSLRGYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGY3</accession>
    <name>A0A0N1IGY3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGY3"/>
    <dbReference type="FunCoup" id="A0A0N1IGY3">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGY3"/>
    <dbReference type="KEGG" id="pmac:106712975"/>
    <dbReference type="InParanoid" id="A0A0N1IGY3"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12510">
        <property type="entry name" value="RRM1_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="910"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="870"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="986" mass="108855" checksum="6DBDA2DD974D6685" modified="2015-12-09" version="1">MSVIIRLQNLPWSANALDIRNFFRGLSIPEGGVHIVGGELGDAFIAFSTDEDARQAMMLDGGKIKEIQVKLLLSSRSEMHKVIETARQSVPILTLTAPAPSPASVPTPTPVLAPPAPTPTSTPAAAPTPPVITPFSAALGTVPIAGFGIPGIGNPHEIPQPAVIEPPAPLVSPSATTSNNEDDNNVEDRNDRKTTKEKRRSRTRSRSRDRDRKDRKRDRRERSRSRDRRRRDRSRSRERRDRKRDRKDRSRSRDRSPGKRGRDRRRSPRESQEKSLELSDPGSMAAVYGVGGAQQPPLIMQHGAAPLSGPVPNMNSAQHRFTDPSMVEAFTKLQELGKKRNPNAFQGEQANGGPRYPAARGGPGAAAAGVRGGGGFRREGRVSRFEEQQQGCCVAIRSAPNHTSYGDVRRFFPYLIDKHGIKMINDNTGRRTGNIYVKFCDPRSKQLALQRRTNELKGAIVDVEDLDDGTYESAVDSFLPYRDENDDEDVSLVISDRRPASPQRAPYSVLRLADLPHFVKEHDIMKAFSDFSLLSITLNDCRMSRSKIAYVQFVKPEDARLAYERKDMYMFGRRQPVITTVSDEEYEKVKPEQGDKAPEVAEPPEEASAPRDPRQRRQPVDSPRPHGAPLLQAQPPVQFFPNAPFVPQQNFGAPFPGAAQFGGFPNAVAMDPRAAAAGWANRPGFPNSNDQMPHVAHKNPRVVSTDMDEQPLDCVLMKGLPTEATDRTIVTFLSDTGAVPARIHLMLDPSGVPSGDCFCEFRSVQEARLAATKHGQDLDGCRVTVDLVSRKVVKEALEGPKPGDGLMPTPVQQPFYDHPRGGYGQRPYRGRGGFDRGGYERGGFRGGFERGGYRGRAHWAERGGGRGFERGRGRGFGRGRGGFMENGVREPPGEPEESDPALEGFGAPGCVLSMENVPFRASVEDILAFFGDFELTQDDVIRRYNERGQPTGDARVAFRSPHDAQRALAALHLHTIHDRRISLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHZ9</accession>
    <name>A0A0N1IHZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Receptor-mediated endocytosis protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01029052">
        <property type="protein sequence ID" value="KPJ21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHZ9"/>
    <dbReference type="STRING" id="76193.A0A0N1IHZ9"/>
    <dbReference type="KEGG" id="pmac:106707342"/>
    <dbReference type="InParanoid" id="A0A0N1IHZ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="14102" checksum="D3C39BF960D82D62" modified="2015-12-09" version="1">MRRLAACTSALRAGVAPRHLWAAPYPHAQLQLRHLPVYRTPRDKISCIMRCVSSIMSVLALTDGSAPSADDLTPVLVYVILKVNPPSLLSTIELVNALGGAALSGEALYWWTQFCAAVAYIKTMDYVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIU2</accession>
    <name>A0A0N1IIU2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIU2"/>
    <dbReference type="STRING" id="76193.A0A0N1IIU2"/>
    <dbReference type="InParanoid" id="A0A0N1IIU2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="670" mass="77622" checksum="5676A9B2017F0C17" modified="2015-12-09" version="1">MALLLKQRDLVVTLKKETVLNIEILSKLYPTSHELTRLINKENWLEKPTQNLFNHLSYYLVNIIDHAASFTWPLYDTNSERTYRNEISNFINSYSNKGLLTPVMSSYLVNPACYKVTMLIFQLSQLAVQSVLIPIMMDQEKTIYNKVTDKYKNKDEDFIKYIDNETEVIFQQRNNFFNKRKTYEKIAELFRKSISNMEAKLKTTNSQYYIDNLVDTYINKYQPDEYVKDKLLEIKDIKKPCNFFDTCLTEVDNQIMELETNWERLITPLLTSGRAAVNNSREIIGRRTEKFNDYLDNGVKSYSEIKSAMEMLNERVLNAESKLPVIPNITFPSQSSKKAVEIPMLPDLTILKTHRDKQFLFENFTPMRMSKHEFNLQRKPNLYFNGPQTKSLTTLFSISRDDFLKSRISSKLGAYDNSNATQNYHNFSLISHCNKVNETIAECSSGFTTQQITRLLSTKKTSSSKKFKYKTDRPETIKKGCLFNESVSTNESVGLFRCHSSPNLFENIERKPLSKLRPRKLSIMQEDSPNSLLEVSGIATLDRNSNCNTPQSPKHQNKSNPQIVPTTSLLQNSPIKSVNFNIDEIKGKMLLDYNESQSPNNYDVQSNNVTPKSNGQLIAKTNSLEKIINRYKKVRAVATTTEQTFCRTIVEEKDNNIINKQVNEYFARYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IK59</accession>
    <name>A0A0N1IK59_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="KQ459670">
        <property type="protein sequence ID" value="KPJ20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IK59"/>
    <dbReference type="FunCoup" id="A0A0N1IK59">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IK59"/>
    <dbReference type="KEGG" id="pmac:106716589"/>
    <dbReference type="InParanoid" id="A0A0N1IK59"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12867" checksum="642C10900274769A" modified="2015-12-09" version="1">MSRPVLSTHVLDTTSGSPAVGLYVDLYKQRDESWTLWHSTTTSGDGRVQFPFSQDSMAPGTYKLKFNVEDYFKKNDKATLYPFVEIVFKVSEGTHYHIPLLLSPYGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKT1</accession>
    <name>A0A0N1IKT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cathepsin B-like cysteine proteinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01024280">
        <property type="protein sequence ID" value="KPJ21130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKT1"/>
    <dbReference type="STRING" id="76193.A0A0N1IKT1"/>
    <dbReference type="InParanoid" id="A0A0N1IKT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="10440" checksum="BC39C7610772C234" modified="2015-12-09" version="1">MTVYQDFFHYRDGVYRRSYHGNNELKGFHSVRIIGWGEDRGDRYWLVANSWGRQWGENGYFRIARGSNEADIESFVVTGLSDVTEANQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IND3</accession>
    <name>A0A0N1IND3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pupal cuticle protein Edg-84A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IND3"/>
    <dbReference type="InParanoid" id="A0A0N1IND3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874038" evidence="4">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="40252" checksum="A1B312E24C3FC080" modified="2015-12-09" version="1">MRTAVVGFEWGRPMFVVVLALVAVAHSSVVPVVSVAKADDYTSFAYDVADPNTGDYKSQVETRVGGTVKGQYSLLDADGTKRTVDYAADDVNGFNAVVRKDPAVVATPAVVATAPAVVSSARTVVAAAPTVVASAPAVVASTPVVASAPAVVAARAYAPSLYAGALYSQKYYSPTVYAAGTPTVVTRNLAGPAYYTASAPVFARTYVAQSPYSYAAYSSPFFVILAFVAATQASILATSQDNDYTSFAYDVADPNTGDYKSQVESRIGGTVKGQYSLIDPDGTKRIVDYTADDINGFNAVVRKEPIVTKAVVPVSPAVIPAVKSVVSTPFHSISSPAVYSVGSPRYYTASPSVYNARSYVAPYYYPRSTTYNSYASPLNYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INF6</accession>
    <name>A0A0N1INF6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inactivation-no-after-potential D protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461146">
        <property type="protein sequence ID" value="KPJ08760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INF6"/>
    <dbReference type="STRING" id="76193.A0A0N1INF6"/>
    <dbReference type="InParanoid" id="A0A0N1INF6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06671">
        <property type="entry name" value="PDZ7_MUPP1-PD6_PATJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="365" mass="40237" checksum="CBE07248A0D9AA2D" modified="2015-12-09" version="1">MHPLYRQHLDCRCKYQQPQVTNHEGDAEQACGCVNCSASHMTPSVAINAIRFNNCPVVDMRWCLSGLRDFSRGKSSHVSPNMTVTVSPDRHTVGAQRWGPPRSVTLKRNPGAPLGVSIVGGKVDIISHQNTANGSEKAIFGIFIKNVVPDSPAGLCGELHTGDRILEVDGVCVRTAQHERAVQLIKAAGNTVTLTVQSLMAWNNDSSDVDVTSPAPSRTLSYKKGPAPPPPTTVNQAPKHDIKITVTSEAGTEKEGEIDAEKEPKEKGSSETESSKPVYSDSESSDEEDERELSGRTYSEKGVEIDRASAGAIKRTREEKEADPEEEDDFGYTTSEWKDTLFTFFNFSFYLIHVYFYSYLLEHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPD6</accession>
    <name>A0A0N1IPD6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPD6"/>
    <dbReference type="FunCoup" id="A0A0N1IPD6">
        <property type="interactions" value="1211"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPD6"/>
    <dbReference type="InParanoid" id="A0A0N1IPD6"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="30942" checksum="EDF25AE4E10DEED3" modified="2015-12-09" version="1">MENKNKVTVVLGAQWGDEGKGKVVDLLAVNSDIVCRCQIRPCYSSTLRNYLDSDSNMWTRNGVVIHIPGLFEELKKNELKGMQGWQERLIISDRAHIVFDLHQQADGLQEAEKGKNSLGTTKKGIGPTYSSKATRNGVRIGDLLGDFAIFEEKFRTLAAGYKRMFPALEVDIESELKRYKEYADRIRPLVQDTVAYLHREINNGKKVLVEGANAAMLDIDFGTYPYVTSSNCSIGGVCTGLGLPPNVIGDVMGVVKAYTTRVGDGPFPTELHDVSILTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPU7</accession>
    <name>A0A0N1IPU7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPU7"/>
    <dbReference type="FunCoup" id="A0A0N1IPU7">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106721301"/>
    <dbReference type="InParanoid" id="A0A0N1IPU7"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000370">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="373"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="527" mass="59222" checksum="F6CE433624CDC787" modified="2015-12-09" version="1">MASCFSGSHFGPGSQEYIPVAEFYADKSVFVTGGTGFMGKVLVEKLLRSCPKIKKIYLLMRPKRGQDVASRLTELTQSPLFETLRKERPQELNKIVPIVGDITEPELGISPADQAMLCQKVSVVFHSAATVKFDEKLKLSVTINMLGTQQLVQLCHRMLGLEALVHVSTAYCNCEREQVEETVYAPPAHPEHVVTLVQTLPDDLVDRITPDLVGDRPNTYTFTKALAEDMLIKECGNLPVAIVRPSIVLSSLREPVKGWVDNWNGPNGIIAAVGKGIFRTMLGTGGRVADLVPVDTVINLMIVCAWRTHFKRGEGVVVYNCCTGQQNPITWQRFVKTSFKYMRKHPFSEVVWYPGGDITGNRVKHGALSLLQHRLPAHLMDLVSRATGNKPMMVRVQNKLEKASACLEYFTTRQWAFADDNVQALCGALAADDRATFDFDVTNIDWDAYIESYVLGIRRFLFKESPDTLPKSRSVLRRLHILHIVTQVATVLFLWRFLFSRSDALRNIWRRIVDYLTRAARLLMAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQF9</accession>
    <name>A0A0N1IQF9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coagulation factor XI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQF9"/>
    <dbReference type="InParanoid" id="A0A0N1IQF9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="157"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="380" mass="40804" checksum="420239172EA6D79D" modified="2015-12-09" version="1">MCNECWKEFKGWLKSFTRTECALVALQLLLLVLFIAFLTFLILHLLACSAAEHFYVIEATKTPHEPFKTSSQTNSTLPTISISSTNHTTLSPDIECTWRPSMKTDSAVHYYDNGQVSSSVVTNNRAMPTWTPEPADEDLADDIDKAYLLALGKVNIPQDIVFGCVLTIISEYCTLTAASCIESIEEVDSVDTFVIIERYGDRHIGQMHTVSDVLIHPEYQGINKRYDVAVLKSEDSLIKYGHAAVTLPSMLDALMITIGEEFNLLGYESHRGRASGEAGRRAVRVLAVRTLAGAQCSSGWSARHLAHGAAVGAGGCGAAPLCAGPARAPPGCSHCAGAPLLRGSRLVGVLAAGPCGEACGPALYVNVATVLDWLNSTICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQJ3</accession>
    <name>A0A0N1IQJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01022328">
        <property type="protein sequence ID" value="KPJ21098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQJ3"/>
    <dbReference type="STRING" id="76193.A0A0N1IQJ3"/>
    <dbReference type="InParanoid" id="A0A0N1IQJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9552" checksum="B75C22EC85E63571" modified="2015-12-09" version="1" fragment="single">VKDPLIVSHWNALNSPTQSCVKINIMAFGYDAVCRTSLVVHVGEKTLKCICRDGRVRHLSYELQELRDLIYCQVCFHATNMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFW4</accession>
    <name>A0A0N1PFW4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460813">
        <property type="protein sequence ID" value="KPJ12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFW4"/>
    <dbReference type="FunCoup" id="A0A0N1PFW4">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFW4"/>
    <dbReference type="InParanoid" id="A0A0N1PFW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="634" mass="71373" checksum="7DD30711F55F95DC" modified="2015-12-09" version="1">MDCFFVSVGLRKRPELRGKPVAVTHSKGSKPQTKREGVDRNTEFNLYKQKQAKKLGKGTGKTEDEIVIESRVDNVGDENSEYGSLSEIASCSYEARAKGIKNGMFMGPALKLCPNLQTIPYDFEGYKEVAYTLYNTIAQYTLDIEAVSCDEMYVDCTELLKDLKVSVQDFATALRQEIKDKTGCPCSTGFGSNRLQSRLATKRAKPDGQFFLTSDLVEDFMFGISLKDLPGVGRQTSQKLESLGHQTCGSLQTLTLGLLQRHLGNKTGAQLFDQCRGRDPNPLTFHTIRKSVSAEVNYGIRFETNDQCFHFLKQLSAEVHSRMQQFKVLGKCITLKLMVRAEEAPVETAKFMGHGFCNVLNKSSNLTNATNDVEIITKEVISLCKKQKIDPKELRGIGIQISKLEQVMTKPNNSGISKFLNKNKNVPGSNYTPKVENDAGTSCDVKNQIKVEDNTKYSITPKKKNTSSHVNKSPKHELKSSPVKRRGRPPKSLKYSLMNAKSSMDKFLGGEIQVKEELPAQTVPEIIREERPKSSDSNQDGLLSLSWEKVRELLRAWLDSGQSPKLCDTRMIASYLSKLVAKKDIDKVYILMNFLKRRTHEIDMDIWIEVYNYVLEDVQNSMIAVYGNKLWINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG43</accession>
    <name>A0A0N1PG43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 33B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG43"/>
    <dbReference type="FunCoup" id="A0A0N1PG43">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PG43"/>
    <dbReference type="KEGG" id="pmac:106714676"/>
    <dbReference type="InParanoid" id="A0A0N1PG43"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="647" mass="72991" checksum="B259F90B82683CF8" modified="2015-12-09" version="1">MDQPLQCKLSSLCLISQHKLEKILSLCGDKADLIIDSSLIKPLERICGVTWLRQHGIEKIYKMDPQLGQTANTNKIYFISACKHKYKCVLDQISSQLSQNPSLADSKCFNIIIVPKVLHTYDSILESKGLYGVVKLHSFSWELMSLDDRLLSLELPFLFKQLYVEQNHSLLSSVSMSLWSLFQVTGQPKCIISLGKLSSSVLNVLEIYNETYTRDYVSKHTDEIDTLLLIDRNQDYASCLLIPATYSGLLNEIFNITCGHLDLNVKETKYKKGRINFTTVSEENNKKVTMTLDSSIDNLYGEIKHRHFSEVLSVLSSKAKLLKNEDIKALGIQEIKHFVSTKLQQVALFKQNLVNHVLASETIISEMNNKFENVTYTESEMLNNRNKKSNFNFVDENFGTDIQIYNSLRLMCLLSLTQGLTYDEYNNLINKYLLAFGYKFLYVFQNLINAGLLFQPVSLKLTLNISNLSGLSDRLPKWQNSFQNQAAKLKQLPSQVDKSKTSPSYVFNGSYVPLIASISNILLTSESLTEALTKLSNSLELKLSGSLLENMKLGIETLNEKLSNLKLNSELDYRCLDVKSLLKKFKTDSKLSSEFNFKTKSVLVYVIGGVTYPEIAACDVVQNATGSKIYVASDCVASGSDYISACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG66</accession>
    <name>A0A0N1PG66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460880">
        <property type="protein sequence ID" value="KPJ11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG66"/>
    <dbReference type="InParanoid" id="A0A0N1PG66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23605" checksum="73949C25D0C03F34" modified="2015-12-09" version="1">MLRAQRLLDLLLEAARRRLHRAPQPVQHPLERELLHRERGDVAGPLSECRPRLHHTRPRRTAARFWRSGRETDPRRASAQAGASAATRAPPRDRRLPRHRLRNVRQCGLARDRYLPLPRCDTRALRSSHVRRTSHADHTHRHRGGRSPTSPVADSLPERAKRSIDMLQRGTERDERTSHTKAYRRASHTKIPADARFRLSAIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGQ5</accession>
    <name>A0A0N1PGQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein XRCC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGQ5"/>
    <dbReference type="FunCoup" id="A0A0N1PGQ5">
        <property type="interactions" value="1672"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGQ5"/>
    <dbReference type="InParanoid" id="A0A0N1PGQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="296"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="620"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="729" mass="77463" checksum="155FCB12365AB833" modified="2015-12-09" version="1">MPRVKIDYVVSVSSEDPDHPASNLLASEVSKRRWLCSAGAGEGAVLLQLQRAVTICGVHIGAHQAAFVEVLVGTADRPVDQYEVLVPRCMFSGPAECRRAGAGAGGAASDRVRSFNVEQLAEGARRRRWDRVRLLCSQPYNKHCQVSLHFNSVRPHLTLKLIRAAALLAAVQQALPVFCGGRACRLRPRLGPGPGLGPSPSHSHSPAPAPAPRDLLLSLGNYSSDEDEFRPGALFAKYRQSLKQNDDNVSSCNSDAQIRKASAQALKNIPDADTRLKKTAIESGGERTPRRAAADNQREVLRGVVFALSGFVNPQRAALRDLALALGARYRPDWTPDCTHLVCAFPNTPKLKKVVASAPHAHVVSGDWLHACQRTRRREPEAPHAPRAPHAPRAPHTPRAPRHKHPARPAHPTHPAHTAVHEDTDDTDDEIEKVRARNKRPRLAPAPDLAPAPDIAPAPAPDLAPTTPPSDNDVSFICDERFKGSVTLSSDSDSATEEEEAGEETPEVGEGSARGTLPPFLEGLSFMVERGAGEGAGEGEGCDVRLLSRYVRAYGGLLLQVSLALFIYISVSTIVQNSELSSAAGSVTLSSDSDSESQSATEEEAGEETPEVGEGSARGTLPPFLEGLSFRVEGGEGAGEGEGAGEGAGEGEGAGCDVRLLSRYVRAYGGLLLQDSDPEQGAAVDYVLCAGGAGGAGGAGGGLRVRADWLWRCHELRALAPTHPYELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGS1</accession>
    <name>A0A0N1PGS1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">All trans-polyprenyl-diphosphate synthase PDSS1</fullName>
            <ecNumber evidence="14">2.5.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">All-trans-decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solanesyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Trans-prenyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_04941</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:55364"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27802"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27803"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterotetramer composed of 2 PDSS1/DPS1 and 2 PDSS2/DLP1 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.91" evidence="14"/>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGS1"/>
    <dbReference type="FunCoup" id="A0A0N1PGS1">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGS1"/>
    <dbReference type="InParanoid" id="A0A0N1PGS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032478">
        <property type="term" value="C:heterotetrameric polyprenyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000011">
        <property type="entry name" value="Decaprenyl diphosphate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00084036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="457" mass="50696" checksum="BEC605D8626629FB" modified="2015-12-09" version="1">MACLSPSRLCARVQDKLMCQFGHKVRRQTVFVKLKPPGPTPLRIFGRTCQRVTTCGPACGSAGMGPAAAGAVRRLASSLQSTSTGSLPDYGTQIVDPYRLLEDDLNGIYEDIRSELERNTNQAELNTIATYYFDGQGKALRPMVAILMARAVNYHVYGENSALLPSQRQVAMISEMIHSASLIHDDVIDQSDFRRGKPSVNVLWNHKKVAMAGDFILAVASMMIARLRSDEVTLVLSQVVTDLVQGEFMQLGSKETENERFAHYLTKTYRKTTSLIANSVKAVALLSGADEATSELAFQYGRNLGLSFQLVDDLLDFVSSAQAMGKPTAADLRLGLATAPVLFACEKYPELNPMIMRRFQEAGDVEKAFELVHKSRGLEQTRFLARKHGLEAARLAADLTDSPYQKALVVTTDLVLNRIKCVRVRVRVRVRVRVCVRVRNNVPTHNERANTSNVYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHB8</accession>
    <name>A0A0N1PHB8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHB8"/>
    <dbReference type="FunCoup" id="A0A0N1PHB8">
        <property type="interactions" value="2083"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHB8"/>
    <dbReference type="KEGG" id="pmac:106720512"/>
    <dbReference type="InParanoid" id="A0A0N1PHB8"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="32911" checksum="78B4F4F21283FFF6" modified="2015-12-09" version="1">MGDKMQDDDGPSDSSLLVIIVDTNPNQRYITEDPKVLTGCLDAVIAFANSHLMQKSRNLLGVIGCHFHKSEYLYPSPGKPLDVRQIDGQYELFTLVEKTIKMRLVNLIKSQPQEEKPGESLLAGALAMALCFISRMRREATPGLRMSSRILIVTGSSDTAAQYINYMNVFFTAQKQQVLIDVCSLDKHLSLLQQGCDITGGLYLKVPSLEGLLQYLLWVFLPEASERNELVLPGRGRVDYRAACFCHRELLTIGYVCSVCLSVFCKFSPICTTCHTVFKIGGPLPIKPKKKKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHH1</accession>
    <name>A0A0N1PHH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHH1"/>
    <dbReference type="InParanoid" id="A0A0N1PHH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="18318" checksum="4483027213C7BADF" modified="2015-12-09" version="1">MKLIARGARLRGYGLAGRRVLRARGVCGVAQGGGGGRVPPACRVRAGAGGCGRVQAGAGGHGSGETRRPPSPDVHRDASSNLVKQSCRRDVCRTRTYTCERSGCSPRTDATPQILCYEWFLYIGACSTKKPAKARLRHRAAQSGTERHGAARSGTERHRAAPSGTERHGVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI55</accession>
    <name>A0A0N1PI55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI55"/>
    <dbReference type="KEGG" id="pmac:106711256"/>
    <dbReference type="InParanoid" id="A0A0N1PI55"/>
    <dbReference type="OrthoDB" id="6617263at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1189" mass="141395" checksum="5B43DDD17515B92E" modified="2015-12-09" version="1">MIDLKGHNLPERQKELNKRVQDATKKKIPFESVRDKHEATDVDKLFKIDLASNYKNIDYILDTFKCGDSLYISRALKCSWIFEDEYSNIINPDYLHQNIFPFMSIKMKKKLLVTIYTHLKTEERIIVFYNYCVEKKLTTIAHKFLIISPENFKLEIINKGLDLKDVWEESVFLKNFFGDSITLLEAYSKTKAGAFIVQKYLLDFRHFYSVSDDRYLDLIEKFVRIEFRMKSDELGLRMSKDIMKKHKDRVLKKPLLYLSILNKTQVVKYSQVEDAKSFAVALLPASASNFWLENYRRTNKYILDVIPKQDLFPFLKKIFTDAYPNEDFETSMHFYNYRFYDMFTNEEKEKWALSQIESQKEVLGPGKDFKWYQFVNFDIALEGIKKYIMITIDKEKRGEMINILVESAKTQQDLEKLFKYYYERHVNESSSNKEHFMKTVILNHNVFEFDDECWNEFNKILYSMHIYSNSGFFYMTDFRLLVVIYNVLHGKEIPEQFRDILYSDFNYLYIDKLTKEKREILYNYLMNLYTVKIKEFDGKSYEGQERISIRRYISLVLRVMEIFEKVKEDCPDDIMRYIKLDWENFKNHHILKEKVIVNILEEGDLIRLLKKDATQLKNKFPNIKETLANTYSFRINQFLRKLKIYFAKDVAKEYLKFFFDIISNPRSNYMFIYTSVYGVFQLADEESKVDFMFKYKPREPKIAHEKINSQLLDIQGAICRYACYSRPPVPLSNVLMYLIGDYVHFSYPMFNYYFVNLPKPLATKFIEATLNAPLSIQKHGLRLAFKSYNAEDLKVLVLTVWKHTKNISLRLLLYKNLFEKILTEDEASQNELYEALKVFTSEIHEDDDKVIYSLLISSKLPQRFIGDLLKTAWESVSQFKEKSANIDSQYQILRAIKSNITLMDRNFVMESIIAPHVNEMLTEKKIKPCYKSRELSDRVKTKWALVAKYIVSVKNEEEVKDSIALVTSIIKACGEMWAMVHDNTYTMRLFCTNFISSLHMNSNNNFENFKYVKTIFEKVLQTVEEVLPLDEMYLTVWELRVVIITKKLCSNLEFTKKDQSEKIERGKLYDEFADEIGNLAVDLINKGQFYRSFLPQINERLINQIKVLARATDEDLEVVIIAICNRLTRFKFFEIYLLALMLLPTNNEPANYDTFVDTLEKIKEMDNPEILSFLLQKYICGDYKRRRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI70</accession>
    <name>A0A0N1PI70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01023756">
        <property type="protein sequence ID" value="KPJ21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI70"/>
    <dbReference type="InParanoid" id="A0A0N1PI70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="99" mass="11147" checksum="FD39994B1AEEA5CC" modified="2015-12-09" version="1">MRARAWTEPVVDETELKTRDTPHVALRLIRNELPKQVDEKGESTGLAAYEELLEARVRDLSIALNMSTALALAEFIEDEIIAPPMPLEVTSKQYNIVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI96</accession>
    <name>A0A0N1PI96_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vinculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI96"/>
    <dbReference type="STRING" id="76193.A0A0N1PI96"/>
    <dbReference type="InParanoid" id="A0A0N1PI96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="40046" checksum="387A1324B832555A" modified="2015-12-09" version="1">MSRVTRTARLAADAGPPHVANDLTQCSQQVELLAPSLVKATQERISSPQQQVIIDKYKALMAEYAESMSKVRILCDRSVDPVDFVQAAGETMQRMREQSGSQDDPLKSAHTSNLITKLGWRVLEAGLNSGHAAHDAELRRALAQAQRRLQATAPGAGARASQQRDWRDVTAEILRTMSQVESALSGESIFQKQLDPNQPIFAAALDLHAAVREWSARDNEIVAVAKRMAVLMARLSDYMNQDKKPEVIATSKAIVKASIEVTKLARKLALECSDLRIRNNLLQVCDRIPTISGQLKMLTTVKGSSLGQDNQEDKEAINMLVGNAQNLMLSVQEVVSAAASASVKIMSQRGPRIRWVRKNYYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK10</accession>
    <name>A0A0N1PK10_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01051845">
        <property type="protein sequence ID" value="KPJ21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK10"/>
    <dbReference type="FunCoup" id="A0A0N1PK10">
        <property type="interactions" value="1672"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PK10"/>
    <dbReference type="KEGG" id="pmac:106707389"/>
    <dbReference type="InParanoid" id="A0A0N1PK10"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="24892" checksum="FD69CA293CF79E57" modified="2015-12-09" version="1">MASLKVYSVGRLVKHITDSSLRSLRGNIYRSSVRGYSTEEKAAEDSSGDKQMPTTLEDCHKQIETLSTEVSTLKQQLKDYEDKYKRALADGENVRRRMMKQVEDAKSFAIQSFCKDLLDVADTLSAAADSVPERAEAHAESAAAALRSLHDGLRLTRAQLDQVFARHGLVAVSPLREKFDPNLHEALFTQEVEGFEPGTVVTVSKVGYKLHERCVRPALVGVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKF7</accession>
    <name>A0A0N1PKF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myoneurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_04891</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKF7"/>
    <dbReference type="KEGG" id="pmac:106708354"/>
    <dbReference type="InParanoid" id="A0A0N1PKF7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="13">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ20293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="52209" checksum="5CC263FF8733365D" modified="2015-12-09" version="1">MDITKLCRSCMKEVASWEKENFDVRVVKMFCFCTNVEIIEEDKLPKQFCYDCVIKIESSFTFIKEAQNVNVTLKNIASRRETSIIVELENCNKLTEVPPTPKNHLKLTLPDYKLCSTIENFDEPILLNNTNESINFTNDNIPMDPITDISFNNSLETNVNTTKDIKQTENLAVDNRNMCTICKKSFSSKVWFAKHMEKEHSGQKYSCPQCSKTFSRASQLTYHSATHSDERMFGCTLCSKRFKRRKQLTAHTRSHSDERPYSCDKCQKRFKLKSILKCHMKVHEGRKQYLCSYCGWAFAQAGNLSVHVRRHTGCLPHACSECGYRAAAGAALRRHKRKHRPEVPAPALLCTHCSQQCKDSSALARHTRTHTGELPYQCGRCPRAFSDSWKRKTHLMRAHGLALHDIPRLRRDGTPAPTTTTCTYLRTASRTHLGTAPRTNLGMVPRTHLGRHLAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK70</accession>
    <name>A0A194QK70_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK70"/>
    <dbReference type="InParanoid" id="A0A194QK70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ05932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="31307" checksum="229A1297921F4009" modified="2016-10-05" version="1">MARAWRSRSPSTRVAEARAALAERADCAAALLLLAEEDAPTVLEAERVLRRAWRAGEAAWRAHCGAGAGAGAGAGTGAGTGAGAGARARRCAAVLAHVKRRAAMCARRLGRLRDAARMFRELAREAPPALAPLATHENLIEVLLEQRAYADVQALVARYEECATSRSAVTVYTAALLRARTAACAAPPARTAADLAALEAMSRAVEFNPHVPAYLLEQRALCLPPEHVVRRGDSEALAYAFWRRNDKYAGSRDDGSKGLRDLTMSVCAGIVDRQESRDPSLECCGDAVVYRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLV6</accession>
    <name>A0A194QLV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H2.0-like homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLV6"/>
    <dbReference type="KEGG" id="pmac:106719966"/>
    <dbReference type="InParanoid" id="A0A194QLV6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052497">
        <property type="entry name" value="H2.0_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808:SF1">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ06538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="22868" checksum="84A83DE007BCEF93" modified="2016-10-05" version="1">MTSISSDVNTSKLKFSVDSILGNNESISTSGSGPVTECVRAQEPPCAGCVAALYRCCRDEPPLLQLPLSVPYAHLHPALRPTTVYRLPLPRASSPQQTSSPRCDVSSSGKRKRSWSRAVFSNLQRKGLERRFQIQKYITKPDRRQLAATLGLTDAQVKVWFQNRRMKWRHTKEGRAGLGGTLGAIKDPDATLTAEDNEDIDVDTLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPW5</accession>
    <name>A0A194QPW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPW5"/>
    <dbReference type="InParanoid" id="A0A194QPW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="11748" checksum="D5E83A8287A7A641" modified="2016-10-05" version="1">MASWPATTAGEVTIDGASDDTAPTRLRGVHARPPLARPARGLISYHSNAPPAPPPRPRCALPLDSHGGRSRSRLRRRVSRRAAQQSVSRRPPEARAVCDILVFKADAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRH3</accession>
    <name>A0A194QRH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRH3"/>
    <dbReference type="FunCoup" id="A0A194QRH3">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRH3"/>
    <dbReference type="InParanoid" id="A0A194QRH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="356"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="852" mass="95471" checksum="702FB1F4F11B6854" modified="2016-10-05" version="1">MENVEESVVKSENKNKIVNMENEAGDISDTEAPDTSEPSVCVSQAPVVDGVSCARENEALGPGGSKKPKKKSRGKKSHVAAKDNVEKGAIRRVHYPGTKFKQFRKRAQSFPSISKFFLPNKRPRKEAFIPPTKFLLGGNISDPLNLNSLQDEDINRAMNAVTPESSPLPTPPRHKAKIDVIIPPNIRDPLNLMDPVDNDEYEKRLEMQQRRPRKRARIRRRTTENMIPSIEVTEEKVENIKEPPPPEPSTSKSRKRSCSDSDNASQKGKEGKKLRRMDSLDKIVSPVVPQPGAWMRARPNQHPAQPERRTSPHRTKPKSDDKVAQTLPVFHSKNTRFQYGNYDRYYGYRHLNAMMDIRLQVFEMHRHLFQNKDVLDIGCNVGHISIAVGRTLGARSVVGIDIDPLLIGRARKNLKAFIPIPTEVPKIEEEKKLEGDVEEEKKVDCDQCKELKCDGCVSTEQKQDKSEDSKKSLTGRKIRKPRKNRKAVNKQDHGQCFFPMSMSVLFGPLDNTSEVAPPVFPYNITFKQGNYVPREDIIASGMESPQFDLILCLSTTKWMHLNWGDAGLKRAFRRMFADLRPGGKLVLEAQNWASYKKKKRLTPTIYENFNSIEMFPHKFREYLLSPEVGFSKCCVLGVPQHASKGFRRPIQLFVKGDFTPSKARWSDAHAPSSHHQPEAEPPRRTVYAPVAPAYRPSDDAPSCGAATPYSPNLDCSADDSPFYNPRSDTYAPSYQPPRPTVYATIPSPLGSASPAASPAASPAPHAPLAPHAPHASPAPHADQLSARGFPAPAPPPPPTACTTTERRLSLICVNIILDPVGLCFHRMNIFYNIILGNIFVMCFIERPPPLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRN6</accession>
    <name>A0A194QRN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-erythrulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRN6"/>
    <dbReference type="FunCoup" id="A0A194QRN6">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRN6"/>
    <dbReference type="KEGG" id="pmac:106718133"/>
    <dbReference type="InParanoid" id="A0A194QRN6"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="26012" checksum="536151CDDA21E10C" modified="2016-10-05" version="1">MEISFKGKRILVTGAGQGIGRGIAVELWRAGANIVALSRTRSHLETLQSEYPSIDIVDVDLADWEKTRAVVESLGHFDALVNNAAVAICEPFLNCTPGDFDKTFDINVKAVLNISQVVARKMVENKTHGAIVNISSQASKAALKDHAIYSASKAALDALTRAMALELGPHGIRVNAVNPTVIMTAMAKVGWSDADKAAEMKAKIPLGRFGEVSEVVNAVVFLLSERSSMINGVELPIDGGFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS12</accession>
    <name>A0A194QS12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS12"/>
    <dbReference type="InParanoid" id="A0A194QS12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="23379" checksum="0970862B2EACF921" modified="2016-10-05" version="1">MESPELTLICMLWPYNIYISPTRLGVSIRTTLALHPRGESLHLTHHTPSFNSRYLGNIPSVHSKLNLMAVLVYHKENEYLLAHHVWPEIDSMHFQAKLPYKKRTREDDTCEFMPLSKRINNLHINNNLASQSILQAADPSHINGIRTEENGISSQTHNHNSDSTPTYDPGVTSSQSRYYYENKLLFELHLERIQRSGQQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT35</accession>
    <name>A0A194QT35_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Torsin-1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT35"/>
    <dbReference type="FunCoup" id="A0A194QT35">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT35"/>
    <dbReference type="InParanoid" id="A0A194QT35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="40360" checksum="14BC48B4D2DE0A27" modified="2016-10-05" version="1">MLYFKLRFFLFYILLLVLNINYVVTEFITASILGGVVLGGGLFGWNTVKDYTYCRYTECCNDKHVPYNLSRLKVSLSQKMFGQPLVNELVNILVAHKESIKDVNRQNKKALVISLHGWSGVGKNYAASMIADAIYAKGMQSRFVKMFMGKKDFDCSDMEKSKKELMATINMIVSSCPTSLIIFDEIHDMCPTILDTIKPMLDHHHAVDGIDYRNSIFIFISNIGGPQIATNLLELYDKGIKRNEVEFHHFEPIIRRTSYYTGGFEKSSTIAQHLIDHYIPFLPLEQHHVEMCALAEFRALGVLQPTEEMMLDALSIITYGPSEDQPIFANNGCKRFVKHIPYVIQKYKPKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTC1</accession>
    <name>A0A194QTC1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative L-asparaginase GA20639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_07833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and beta chain produced by autocleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTC1"/>
    <dbReference type="FunCoup" id="A0A194QTC1">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTC1"/>
    <dbReference type="InParanoid" id="A0A194QTC1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033345">
        <property type="term" value="P:L-asparagine catabolic process via L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04702">
        <property type="entry name" value="ASRGL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000001">
        <property type="entry name" value="Isoaspartyl peptidase/L-asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033844">
        <property type="entry name" value="ASRGL1_meta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF41">
        <property type="entry name" value="ISOASPARTYL PEPTIDASE_L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="11">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="316" mass="33025" checksum="0CF8651FC64940BA" modified="2016-10-05" version="1">MGLAMKPILIVHGGAGDIAQSRVQGKLDGVRLAVREGYRVLQHNGSALDAVEAAVVSMEKDENFNAGYGSVLNLAGEVEMEASIMSGENLDVGAVTLIKDFLHPISIAHKVLTDSPHSLIGGQGAKQFALDKGFPMVPQESLISENAQAALKEFLEKGGEFGKTEVGIAEDGVGTVGAVAIDINGHIAVATSTGGMTGKVVGRIGDTPQIGSGTYADDNIGGVSTTGHGESILKVCLAHSIIKLMESGVDAETATKEAVTAMTTRLKNTAGAITLSKDGDVGVYFSSKRMSWAYIEDEKLFYGIEQGEVLEENYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTX2</accession>
    <name>A0A194QTX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTX2"/>
    <dbReference type="InParanoid" id="A0A194QTX2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7130" checksum="937C7042CC85BF4A" modified="2016-10-05" version="1">MGFDADEATWEQSKLCKHPKPELGGPSFHSRDSERGAGSGKYVQSRARAPWQWRAGGAAHALYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU66</accession>
    <name>A0A194QU66_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_15153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU66"/>
    <dbReference type="FunCoup" id="A0A194QU66">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU66"/>
    <dbReference type="KEGG" id="pmac:106717092"/>
    <dbReference type="InParanoid" id="A0A194QU66"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="768" mass="88022" checksum="2DAED269C0B012C7" modified="2016-10-05" version="1">MAQYNRRDITYSALNNELTPPLGRSAQDANATPTMITLDHEHDDTTNVIIHKVPKTKGGWTHIEDLDSFFTRMYKYYVRGGFYPMIMSDLFYLLQFIFIVWFSTFLVHCVDYPRLFRNDTNANRSEKLSLSDVIYPTSECVNRISWKWWCVITLCTIIWFMRLFLSIYHLYHAYDTKLFYSSALKLNENDLAWINWSTVQDRVREAQPEHHMCVHKQEINELDIYHRILRFDNYMVAMVNKNLLPLQIHVPFCGDFHYLSRGLKWNLEFLLFSSPWSPWENCWQLRECYKDHSKRMILARQLDRQILVLAFVNFLLAPLIQGWQILYFFFNYAELIKRSPASLGLRTWSLYARVTLRHFNELEHELRDRLNRAHKPATKYLASFSSPITTVVAKNIVFLSASVLGVLVVLSVYDEDVLTVEHVLTIITILGCVLAGARALIGEEERLGGGCTGPARGEELFVQVLGHVHYLPAAWRGRAHTKDVAAHFQQLFQFRAVYILFELLSPLLSPFVLLSLRSRALDIVDFYRNFTVSVLGIGDVCSFAQLDIRRHGHPDWQAAGKYGEKVTTGNAQYNQGEGGKTELSLVAFSCRHPGWQPSEPAQRQFLRSLRQSMHHAIPTNNALNKTMLGSYIQQSIFGTNTPLPAVLSYYQQQKQPYRLPDMDETSDEDECTSASVSRNVGSGMSAMGNPDSGVSIPGPLNRFDPNTALLASPDEARDMSVSTLHLYDLHLSQAGQSVSACCTKNCSERNRSESRWASGEETPLLHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUJ3</accession>
    <name>A0A194QUJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein NDRG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUJ3"/>
    <dbReference type="InParanoid" id="A0A194QUJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="27476" checksum="9E7227821CA182CB" modified="2016-10-05" version="1">MDELANQINYVLGHFGIKTFIGFGVGAGANILARFALVHPQKVDALTLINCTSSQAGWIEWAYQKMNSRSLRARGMTQGVLDYLMWHHFGRFAEERNHDLAQMYRGYFTRHVNPTNLSLLMDSYVRRTDLNISREGHTIRAPVLNITGALSPHVDDTVTFNGRLQPTNSTWMKISDSGMVLEEQPAKISEAFRLFLQGEGYVAPLSPTKIVAFRRLSADAGRRRCRHSPVIRITENPISEAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW28</accession>
    <name>A0A194QW28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW28"/>
    <dbReference type="STRING" id="76193.A0A194QW28"/>
    <dbReference type="InParanoid" id="A0A194QW28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="546" mass="61709" checksum="34DE6EF0DBA293E7" modified="2016-10-05" version="1">MPSTHLNLREDDVIRLALEFLHNRDLHITQLSLERETGVINGNYADDVLFLRQLILDGQWDDVLEFIQPLSALKAFEADKFNYAILRHKYIELLCIRSEIKAYNNVENIVDEVVKVLSELEKLAPTKEEYSNLCLLLTLPSITDHAQFKKWNPSNARVQCFREVYPLVEQFLPCDKKSTGTVAKCAKNDRLMQLLIKGILYESCVNYCQAKATGSKEAQSNEVNFSQLLDGSGFDESDLSLLSWLQSIPAETFSVPFEQRMLNVDVEKLDRPSLHTSWTEHMLVTPIKPRTFPHLAMPFRRPRSAADAMTRSLRPLPDGAPRHTALMALSAIDYGPSSSCFAGFHLTGIKGSKLMNTSVDRLFDNKNGDSMYNGINETLKPIEEQLKPTGDIASSTKTNESNSIGASNATTPEHRGQDYSVSTSISTTAASTERSSLAERAPQELEPKLVPTMEGDFRRELLKEYQIQKQRECDDYIRNLCSSELRAPKSMEQQGEATSGFTQSIRLPQQMNQETSVECKHPISKFEEGELAQNLEGLMIWMREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWX0</accession>
    <name>A0A194QWX0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWX0"/>
    <dbReference type="KEGG" id="pmac:106716914"/>
    <dbReference type="InParanoid" id="A0A194QWX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264702" description="Cuticular protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="10979" checksum="4A717CBBD2F6EA41" modified="2016-10-05" version="1">MVLKLFVVLLLAVCAFEVEAGTRIVRSPQFGFASQASAKASAGGFGRPGFAKPGFGSQGFGRPAIGKPRFGGPGFGARPGSGTNISISKSVSISTGNGGVARSNAQSASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXA1</accession>
    <name>A0A194QXA1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXA1"/>
    <dbReference type="STRING" id="76193.A0A194QXA1"/>
    <dbReference type="InParanoid" id="A0A194QXA1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="38663" checksum="0DB30E917DA73197" modified="2016-10-05" version="1">MRLAMKVCREESGRRVASRGSSGSQTRAPSAPHHSHSARDSCVCWRPLPHDHTLSTHEANTVAGRQLYAYKKSCHGLRICFRVVVTCLLALTAVSKADGTLDGLIYAPGHSSVDYYAYPSYAFEYAVKDPHTGDNKAQWEKRDGDSVKGAYSLVEPDGSIRVVEYWADAKSGFNAVVKRIGPNLHPVAAPIYKAPIPLLSHGSAVAPISVGSVAKIEALANAPLVSGSAYSGAVSSSAFYKAAPIAKSVAPIAPILTTPIYKAPIIPQPIITESYEKAPLPNPILAESIYKALSIPTAPIKTAPLLDPGLLAPWPLLKSTEQLSPISLGDYLLKDSLLAGNGYDLGYDAHGASWDTLGLGYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXV6</accession>
    <name>A0A194QXV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXV6"/>
    <dbReference type="InParanoid" id="A0A194QXV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12129" checksum="F9D0C084EABBFE0B" modified="2016-10-05" version="1">MRESELRIFYERNKIFEYFVAKAAGGRALVRRQTVLAQHQKQQQTVLGGGAANCLHHCLQLLLARVPAADVLYAFLQATHAYALRTLWRRDTSSPGSRRIASKAICSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYA9</accession>
    <name>A0A194QYA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYA9"/>
    <dbReference type="InParanoid" id="A0A194QYA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF4">
        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="118"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="361" mass="41350" checksum="D688BAEEC3BD236C" modified="2016-10-05" version="1">MGHRVPRYSSILWGVCMPSSCSSYDLEEELSQKLSGLDISVRVYNTMCTVKNVNRPYSFGKTLSITFFLAIILLLSMGTILDDGKEGATNFEKLLNAFSLKRNLRKVFDLSEAGSRVKGVDAFRGMNAFALLIAHKSMAMAHSPFVNKTHFSAVFGMPWAVIGRSAIVYTDSFLYLSGFLNAHNLFQELERKGTIDMKSRLLARWFRLFPLFLSLMLFCTYILPDVNNGPQWNLVVEEHSRVCEKNMWKSFLFIHNYFGFEEMCLTHTHQIGMDMQLYVATLPLMLVLWRFRRLGWVLLVGIAAASTVLRYLAIHWYDISMFVYYGISTPKSLNYTRQEEQQGGIAPPIKKKHILLRAPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYL8</accession>
    <name>A0A194QYL8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYL8"/>
    <dbReference type="FunCoup" id="A0A194QYL8">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYL8"/>
    <dbReference type="KEGG" id="pmac:106715829"/>
    <dbReference type="InParanoid" id="A0A194QYL8"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="530" mass="58203" checksum="540D1AE276F30AE9" modified="2016-10-05" version="1">MDIIENEETDKDTVEENVLEELFPKKYDLMTETEVSLKKTYINKLSGTKTLKYSIILPDNTIEVYELNNSSLSRVCVMSGHEKTVTETVFNPNDDNLLFSTSEDGLVKMWDTRAGGSCVLDYKDEEEKIIRPYECMDVSYNGRVLCTGSQLVEDDAYLVFWDQRVPKPLGGYWNSHTDDVTQVKFHKEKVEILATGSVDGLVNVFNIMEQTEEEALTHTLNAECAVDKLAWLGDAAVACLTQAHQLQLWSTASARRALHCDREHIARSIKRSRADDCYLVDSFTSVGGRPVLLAGSYGGDGSTLRALAVAGDRLLPYADFPRNRQLVRCCYHDRARDLLVTAGESGIVSVWRGVPDHSGVDEADDADLRDHVDVDASGDSDDSGDGDGSEDEGGSEDGDDSEDGDGSDDGDGSDDGDKSDDGDKSDDTDKSDNSDKSDDSDKSKVSDKPADSVTHEDSSERHDLDKADSNKQETLGKAEVSNKAEDSDKMDSSDESFESSETEGGEVQDEVSGKLTGALARLQARRHRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZQ1</accession>
    <name>A0A194QZQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZQ1"/>
    <dbReference type="InParanoid" id="A0A194QZQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="276" mass="29786" checksum="81BEA3B6031D2344" modified="2016-10-05" version="1">MIEKVLPLIAIISTANSQLYPVTIPCSQGGISPVALQPVYAKVRAAPPPSLAVPPSVLAPIPRGVLPNTNIVLPKQQLVCPVEYSIIGPSLSTLPLPTPTISEPCHTPLSIPTYPEYILTDYTNDLCVPEPVFDILGCLDPILTRYGTISEVLIPEIPQNPLISPFLPAASPVSSLAPPIAAINTEGLILRNVNNLSPNKPYNGQAIASQNAPQYNILSIPKRMIYSGQTNRMTRRSNSNDLLANKLRLSALQNVLAATETRKAGKQINLRNIRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZV5</accession>
    <name>A0A194QZV5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferin 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZV5"/>
    <dbReference type="STRING" id="76193.A0A194QZV5"/>
    <dbReference type="KEGG" id="pmac:106715293"/>
    <dbReference type="InParanoid" id="A0A194QZV5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="444"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="537" mass="59380" checksum="43891FEFBF0FA5CA" modified="2016-10-05" version="1">MLKNPLYVYGPEDRYVPAKLNAGDFLLQKIWEHKEKVSMINGATDEKLTYGEMAQEAMNLAVSLVKLGVRKGDVIAICSENRREFWSTVIGVICAGCVVTTINTSYTKDELKHVTGISKPKYVFCSPFSYKAQAKNFRTIEYIKKIIVFGEEKQKNTLSYNDLAIIGRGSNSMLKENVNIDDFDAIEVTGQDDVAMILYSSGTTGLPKGVMVTHLNVLTACSSTTEMPDILSLTITPWYHTMGLMSHLIGFVKGKTTIYLPKFEVQQYLQTVEKYRVSQLTVVPPVLIALCKTPSKHDVSSVMMVASGAAPLHKETADGVFKRFPNAQAVIQGYGMTECTLVVAINANPDKSASVGQVNSNTIVKIVHPETGKVLGPNQEGEICVKGAMIMKGYIGKKKQDDFDEEGFFKTGDIGYFDDDKYLYIVDRLKELIKWKAYQVAPAELEAVLLKHESVRDAGVVGMPHPSAGEVPLAFVVAQPDSKVTEAELQKFVAERLSNPKHLRGGVRFVEAIPKSLTGKILRKDLRKMLKSTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZX6</accession>
    <name>A0A194QZX6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PC4 and SFRS1-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZX6"/>
    <dbReference type="STRING" id="76193.A0A194QZX6"/>
    <dbReference type="InParanoid" id="A0A194QZX6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05834">
        <property type="entry name" value="PWWP_HRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31700" checksum="57564F85DB89747D" modified="2016-10-05" version="1">MGKKVREYKSGDFIFAKVKGYPAWPARVQRLNGKKYFVYFYGTGETANLPPNMIFDYAENKDKFLTKTVKRKDFNLGVKQIEHDFANNVPVEEVVGTALTNTSQIDTGVDDSDETGGLVIDEGKKGRKSTKGATPAKPIKEPKTPRGKAKKEEQKEEVEEKKEEEIISRSGRKIRPKRYIDEHTEENTTLPSPAPKKRKVPSPPPEKEKEPEKEKPKPDATKAKTDKTKLFNTVSQSELEDLKEPFAQVMKILKYVTQSFIYSNQSSSVLDGDDLQNIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZY4</accession>
    <name>A0A194QZY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTB domain-containing adapter protein ced-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZY4"/>
    <dbReference type="FunCoup" id="A0A194QZY4">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZY4"/>
    <dbReference type="InParanoid" id="A0A194QZY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="177"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="576" mass="63077" checksum="890FAD588D0BD54E" modified="2016-10-05" version="1">MSTLLFWQGRGKANGAPNGRNWIHAPDALVKGHVAYLVKFLGCTQVDQPKGIEVVKDAIKKLQFTQQLKKSETKDGAKCKKVEITISVDGVAIQEPRSNNILYQFPLHRISYCADDKGAKKYFSFIAKGGSTVNGMNGHDSGSVEKHECFVFVSTKLASEITLTIGQAFDLAYRKFPLHRISYCADDKGAKKYFSFIAKGGSTVNGMNGHDSGSVEKHECFVFVSTKLASEITLTIGQAFDLAYRRFLNDNGKYIEMQKLTLQNRKLELQMNVYKNRLQELSKITYKDDLSAYLARNSLSEITEFKAPQELDKQIASLTLANGFSAMNGNKTSDNGGDAMSNNSTDTFNSSDNNLLLATPPPAHNGKSSLATGYVCHLISQLSYFDPRAFESEPASRFAAPAEAPPTAAPPLLAPPPKASKRQTSPQQVASPINGQTQQMSPINGNDLFGSTPFSIPNQTVQATSPFTVQNTNKPNYDISDFNLQTSVFNSNTFTNGLTGYDPFDTQKTGNIFGNGFGNTFNGFGNLSEKQTVELDSSFNGFLDKTISEMKDGFSRGISFGNEDFSIDNLDPLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0G1</accession>
    <name>A0A194R0G1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUAK family SNF1-like kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0G1"/>
    <dbReference type="STRING" id="76193.A0A194R0G1"/>
    <dbReference type="InParanoid" id="A0A194R0G1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="749" mass="81408" checksum="2172F6B6979EE6BB" modified="2016-10-05" version="1">MQNESEADLVRIRREVQIMSSVRHPNIVHIYEVFENSEKMILVMEYCSGGELYDYLSQKKVLEEEEARRLFRQIATAVYYCHIHKICHRDLKLENVLLDDTGSAKICHRDLKLENVLLDDTGSAKIADFGLSNVFKETSLLSTFCGSPLYASPEIVKGTPYIGPEVDCWSLGVLLYTLVYGAMPFDGSNFKRLVRQISNGDYYEPKNPSTASPLIRDMLTVDPLKRADIAYICDHPWVNSGCPSSCLDLAQALAAETPVRLDLLLSLAPAAASHTNSVVVPTEAELGPEESCADLTSSTSIPVEPSNSAEKRILELVAEGGEDAIKPSPTRTIVSAGDNKRKLELAMSASGLHRKKEKVASCASVAQLPAALPEEGSLDSPPADEDLPTEPPQPCLKSSATMTIAPAPVELAKDATVDIAKKMPKEEEINDKPRPTTNKVTSPKIEEKSPFEKQEEIKAELGPEESCTDLTSSTSIPVEPSNSAEKRILELVAEGGEDAIKPSPTRTIVSAGDNKRKLELAMSASGLHRKKEKVASCASVAQLPAALPEEGSLDSPPADEDLPTEPPQPCLKSSATMTITPAPVELAKDATVDIAKKMPKEEEINDKPRPTTNKVTSPKIEEKSPFEKQEEIKVEEQKPASVATTTDKLTSLSLTQPTPAAAPTPTKPKKLSIGGHVGSFKEQFERRASLTSAPEIKRNVSKPVVSKIAKAKAQSEDRDLPAKSPDNGTVRLQQIGIEPSQVTYFLLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0Y1</accession>
    <name>A0A194R0Y1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nose resistant to fluoxetine protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0Y1"/>
    <dbReference type="InParanoid" id="A0A194R0Y1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33730" checksum="DA27C914DDDA1C7C" modified="2016-10-05" version="1">MEYAQMPPVFNFDRYGICINQKDGIYCTINIDLVTDEESDLFNIIQEYSERKETHYNHTRLFHGVCEKEANEQRTAKKNKWLLCFSVKQNWRRLTAPTRNGSKRRVTRLFGLNGMRFKFVRALFRNDPTFNAYRRTHTNISCYITGLSLGLLISKLQKKKMNTKVSAKYKYLYWAIVPIGIAVILTSGIFYMDGVVAPLIYKAIHSSALRAVAGILLSAIILGMVLRIEDTYRGILEWRGWTTPERLCYSAYLLHLIVIQILTGTRTTLIYITEFQMTIINPKLDNAVTGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R109</accession>
    <name>A0A194R109_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R109"/>
    <dbReference type="FunCoup" id="A0A194R109">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R109"/>
    <dbReference type="InParanoid" id="A0A194R109"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264820" description="procollagen-proline 4-dioxygenase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="298"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="435" mass="50075" checksum="3CCFF13D7FD3D9D0" modified="2016-10-05" version="1">MRCQYLLYAVCLATWSWTNAELFTAISEVEPLLETHKKIIDDLDDYIQKEEKRLYVLKKHLNLYKKEHGMAMEDIPNYLGNPINAFTLIKRLTTDLDFIEKSIKIGTGDVKAALQWTKKLLALEPKHPRARGNVPHFQKTIAETEVKLKRRRRGETGEDDEEEDSKPMSYLSKERKVYEALCRGEIEIPSEMSRRLKCSYLTENHPFLKLAPIKMEQMYIDPDIVVFHQVLSDDEIEHIKDMAKPRFKRAVVHDPKTGELVPAHYRISKSVWLKDEESDVVSRVSRRVADFTGLTMDTAEELQVVNYGIGGHYEPHFDFARKEENAFKKSSGNRIATVLFYMSEVAQGGATVFTELGLSVFPVKNAAVFWLNLHPSGEGDIATRHAACPVLRGSKWVSNKWIHQGGQELLKPCNLEYQQEDVMRKIPRPISRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1A3</accession>
    <name>A0A194R1A3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Antitrypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_14933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1A3"/>
    <dbReference type="FunCoup" id="A0A194R1A3">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R1A3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19579">
        <property type="entry name" value="serpin1K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000030">
        <property type="entry name" value="Serpin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264837" evidence="9">
        <location>
            <begin position="30"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="10">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="41746" checksum="B5FEA2BE9FD7513E" modified="2016-10-05" version="1">MIYFACKPQYVRYFTISVVVLVCLATASCNNDANDAALLAEGNSKFTARMFTEVAKKNPQKSFVLSAFSVLTPLAQLSLASEGSSHDELLKAIGLPNDEATKTAFTQVDSNLRSVKGIDLRMANRIYVANGYTLNKDYATVVRQTFQSEVKNVDFTASQSAAKEINTWVEQQTNNRIKDLVDPNSLDADTRAVLVNAIYFKGTWKDQFEKRLTSDNDFYLSHRKSIKVPTMYRKGDYNYGESAELNARILELPYVGDESAFYIILPNDVVGITELLDKVKDSSSLEKALSSLYEREVEAYIPKFKIETTTNLKEILPEIGVKGIFDASKANLSKLITNQNDLYVSDATQKAFIEINEEGAEAAAANGNKEKLFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1L9</accession>
    <name>A0A194R1L9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pheromone-binding protein-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1L9"/>
    <dbReference type="InParanoid" id="A0A194R1L9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="161" mass="18188" checksum="58E247B2A23E82B2" modified="2016-10-05" version="1">MPIAYGLRPWALTTEPNRVFRFVFFPGVYEGILDQQKPQTVDKPSVQLPPLVLNTIKEAASTCLKETGASQEVSDNFLKLKFGTDPDSKNFLYCMGRKTNNADEDGHLNEALVTLFEGNEHKDEVAKVIEDCNKHQESNKIDTMHKAVECFYKNTPVHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R224</accession>
    <name>A0A194R224_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rabphilin-3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R224"/>
    <dbReference type="FunCoup" id="A0A194R224">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R224"/>
    <dbReference type="InParanoid" id="A0A194R224"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="5">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="270"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="402"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="542" mass="60966" checksum="33E504C99B7AAE82" modified="2016-10-05" version="1">MCVIRLRTGWCTARGEPLSAAEREAVAAVVRRAEQLDELEARRVGRLVARLEGMRRSAQGPAPRACLLCGETSRLLAPLRTCSICRNSACPKCVIDTPPHRSPIYSREQYMCNLCAETREMWKKSGAWFYKSLPKYILPERKVTGRYHDTELARSLQIRQEAGTISNECKTDSEPGSPLSIHAPSFSRQPSNTDSRKSISSQDTHHEWSETDILTHGVSGLSLHRTESMTQRSIAGLKRTSSKGSAYSLRSIRKEVPKTQPEKPTIPDSGFGTLEIKLAYDNATSSLAATVLRARGLIGMDMTGLSDPFCRLEILPREGTYSNRLRTKTVHKTKNPEFNETVHFFGITESDLAAKSLEIVIFDDDRYGCDEMGSAIVSLRDCVKAPTQLRLALSGASGTEPTGPRVLLALCYNTKKRALVVTICRAAELPPQDSNGYSDPFVKLHLDPDPYHKKHKTSIKWRNLNPVWNEEFLFETRPTELSRQNLTLTFWDKDYGKPNDFLGSLVLGASSKGRRLKHWMDCIKFPDHRHEQWHALTDTQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R302</accession>
    <name>A0A194R302_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Golgi apparatus protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R302"/>
    <dbReference type="FunCoup" id="A0A194R302">
        <property type="interactions" value="1819"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R302"/>
    <dbReference type="KEGG" id="pmac:106714280"/>
    <dbReference type="InParanoid" id="A0A194R302"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264882" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="323"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="387"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="645"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="711"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="894"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="959"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124712" checksum="73CAA06A733F308C" modified="2016-10-05" version="1">MFHLVLIQAISLLSLSINNVSGVQAIGGLIRSQKGIYSVDLGGCGNIQKECSSLRDDLNILSCALNATRNNKTQASLLCQHKVWMHQAELLDNAYIDYKIKEPCQDEAAIIDCLNPSDLSIDCILKRKPSVKDKTCLNLIDKIELLIFNDWLITGNFLRHCFDDINTYSCGRIPTDLRSMSQSQTLNCLQGLVENLRPECQSEIIVLNELKYNTIQLDKIVFAACNVDGKNFCADEVPGSRLMYKCLVRHKYEKGMTKTCQDQLFYVQRNVVNNYKNSKGLVKSCKDDIRKYRCRKGVVEDKEVRLAQILLCLENISQNDSTKLTPECIAEMTDHRKMLMEDYRLSTELMQNCANDITSLCRGIAAEGKIIHCLMEHARPKKKKEKRISMTCQRSLEALVQEADPGEDWRVDPILRKACKPVVDKACREINGGNGRVMSCLMEKLGTESMTPDCETALLQIQYFISRDFKLDPQLYKACIYDAVTQCKAKLQWADASEHQSAKDPLILPCLYNYAYNSALRGILKPACEQQVRRVMRQRAVSVDLLPEIEDLCIDDLTNLCFENTGKGEEIMCLQNKIKDLSPKCREVVTNFTETQSGHIELNAIVSTNCRIPIEKLCSSELNSKKDDDDVLDCLIAHKNDAQVKANVKCRAAIEHEQLIALKNYRFTRKFKNACKSYVVRFCPKAQTKSQVVTCLSEIVRNDTITRRKHTIFKDCRQQLRSQLFQQKENIDLDPDLKEACARDLQMYCPAVPHGESAALECLQTAKGKLSEGCRKAIFVVRKQEFTDNAIDYHLITSCNDMIDLYCHNTEASNILDCLKVHRQKPDFDENCKIVIVNRMIEQNMDYRFNNNLQNACKMDIKKFCFKIIATEPQDMELQGKVLYCLKEKFRESKLSSTCENELANILKEQALNYRLDPLLGKLCKAEIQTICSTSKDSVTNADGQVEECLKNALLSHKIVSAECAQEVAQIIEETEVDIDADPLLERACALDLLKYCKELEHDAGRRLKCLKIILNDSNRKLEAECEKQLSSRLEMYRYVAANHAENLEDIYNELSSSPSKKYFLVVGISVVGLIFIFGLYCGRMTKHAMYVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R350</accession>
    <name>A0A194R350_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R350"/>
    <dbReference type="KEGG" id="pmac:106713735"/>
    <dbReference type="InParanoid" id="A0A194R350"/>
    <dbReference type="OrthoDB" id="7697968at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="161" mass="18495" checksum="2D3BC17A40D92682" modified="2016-10-05" version="1">MFTDDNSDKESEYEERNLEECTNITKKSLSTVGFRSNADNQNARPLTLRATQSFTGAVEEFKLCGNFQRLNLCNRMNVVPSQKIAPVCPCGCLLRPCVPGPFRTREQTTLALHVVSPDVLNYHGYNFEANQIALFWKKDCRTFLWKGKAKKKNYMHVESHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R427</accession>
    <name>A0A194R427_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R427"/>
    <dbReference type="InParanoid" id="A0A194R427"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="82" mass="8611" checksum="78B0E638891E4970" modified="2016-10-05" version="1">MSHGAVKSSRNGNGVQSVHGGQGGQGEQGECSREGSQSLPPPPDGGWGWVVVFASFMIHIISHCHCRPLTTGPLSRRHHVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R528</accession>
    <name>A0A194R528_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein ELYS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R528"/>
    <dbReference type="InParanoid" id="A0A194R528"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="434"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1786"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1835"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1336"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1620"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1630"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1695"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1711"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1725"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1793"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1961" mass="220869" checksum="87DCEBFCD2F696B9" modified="2016-10-05" version="1">MNDFSSATIRFQIELNGSEESNSLIGGRCISCHTYTISSPLGEEGEDSMLNICQLVWECWGEEGAETTQYGMMLFDLDQWYKDQMPATYQLESNAFMSVLRPAAVGEGCGPALDARLVVTSVAPYSHATRLEEHFYPNSLQYNCICLNTSEAAILGTVGVQRQIINSIDEAGPTVLLSPGRLYHACVTAGLTPLYVPYSHGYGRNVTQEEQRRFLLSVALEARLTRFLKRCAHDWATGTHTGLGCTLSFLVEWCWKRALELKENAKELVAPLFTSTILPDRNIMRCLEHCVQQLTQLTGLLDAILTKCCNLVVPDALSEMEEKYKGIGIVSLYFQVVQWFLRVGLLPERHDGYEALPYPAHQLYNIYKKRRLKLHRLQENAPQEAEAGHRSCALLYIDQLIENEFGGQARLKLHRLQENAPQEAEAGHRSCALLYIDQLIENEFGGHRTHEMWMKGGSECEGVYPPPSLYSLLRLYLLPDVAEEHKHSLVLYLLLDYCTVYDEIRYEAVIRRLMQFPTMFGLSNTAIKATQAFWHLDHRDFDFALDQLQCLTGNTLSDWQHRVVLSSLLAQKKTQAALQYLHVRKPAPIQSPIRKDGISKVNDHDKLDDWQSCCNLYLARGLVFEAIDVIRMCVRNAATSEEKVRVLNFFYKGCRNTGQLSKVLQVTLLPGEEEVFIKYLKDCNDTQTSDILIMYYLQQARYVCHSVLFFHMLLRHRRSLSISVNSSLSDDPNASIESIADIPITLINPRYSNKGRQKSQSPKQDKCMEVDDFVCELRPMNETPRGRRSREISGQSTPLIHRSRSVTPERLDSPVLKTLQTNRSTRSRSRTPEMSPGSLEPIPEQPRQERDSDPHPAKTTLSIPRRLRSRSRTPELLESRVMESPKLTAITESPAKSYESPAPSPTRRTSRSRSHTPELNKRSVVEAPKLEPITETSGKSPYNDSPTSSPTRRALRSRSRTPEVEKLPEQTVDSPRSLRSRSRTPDVEKLPEQPILSSPRNLRSRSKTPEKLLSPKKDIASKGRKPLSRLVLEANAFAKTKQMGESSDVQTKESTTEQSESIIECTPLKASNTKSLIDVTFSPIVNKSILQSSTESFSLTEKVIQINESSSSTDLKPLPAFTTLHEVYFEKSVLQTDESSIIQSSLQEDSQKSTEASVPDVEMNALPQFTPINESDFNKSVLKSGDSSVAGNENKPTDVPKAIAFTTFNEAEFDNSVLKSHLSSVEISHESNANEEGKSYRDLSSLMTSDSDIEMVDDQKWKYKIDNENKDSVIQKEKEKIVEIEREINEIEEDIAEGDNSSDEENAEDSSGEDNVEHEDSSDEEIIEGENKEESSESEEADDEVSVSDSSDEVICLDDDSDSNPSDVNQQADKQTSEEIPQTNQTETQTEKIDVVENKTNTDVVSVETEKAIDEPKIEVCEEKPQEIHTETIIEVKIDQDIEMKDPENVQEQSIDVLNQANISLLTDDNSDVNLTYSDDSNHKEIVPAQPIVEVEVMVEKIAPTETEKNEIVTSNIQDMDVVDFCQPIATEPALIEEVITQESNEETEIKAESAAIKEPKDIFAENTLENTPAILETESVHKDTVENMEVITTPENITENVKTDITEMLKQNDDEIKKTKAPATRKRTQSTSSNKSNQDIEQEIPENITLEATTPSKRVSKSPMPKSRVMPKRRSSKDIADDIDESVTDETLTPRRRSTRSRSKNLDDNSSVASESSVKSSSSKIEEPTDKKPVARKGRKSILNTKTELSVIPEVEDNSQKIEESNQDILSEILTTERLTRNQKAMLESKLRPSTPRSRRASAASKSEASIDEDNTPDIHTIDRVQLLDKETFDGRADDEEFPRASPTLSDTVKPRPRTARSASETETQAKAKKITRRTSVDVTLDASPVRGRRASFNRACEALHTPKGRRPSVDTKKEARFGKTTLDKRRRWLEGLRSAINRLLGNGDITRSCYNSWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R549</accession>
    <name>A0A194R549_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-dependent kinase 5 activator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R549"/>
    <dbReference type="STRING" id="76193.A0A194R549"/>
    <dbReference type="InParanoid" id="A0A194R549"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24783" checksum="F290792135B68256" modified="2016-10-05" version="1">MPGLSRPPRAGLMGTVLSFSPRERRKQATRSCGCALSIGRCCCRAGRFLLKKLLRLKSIVCDLYRASPERCNRKAWKVSRRCNCKVGCGLKGCVTPDVAFINPANVVFVYMLVRELVDGERIARPQELQAVVLTCLYLSYSYMGNEISYPLKPFLVEDSKDKFWDRCLLIVDRLSFNMLRINSEPGFFTEVFTELKACGAVESTPPAPPHPAPPPPHALQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R719</accession>
    <name>A0A194R719_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R719"/>
    <dbReference type="InParanoid" id="A0A194R719"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="252" mass="28670" checksum="23D1D3D9AD71DA10" modified="2016-10-05" version="1">MDYEIDIEEHDVLDNPVIKSIFPDLTKLKQEVLGDYDETSIEEQNASKDYIDPKLEDLSDNTSMPLEENIDEDFNVCNRPAAFIGNKIILGSKPNKDRSNLSKRNVSDSTVSLQNTTVLLKNIKPFLNNCRRYCELCLILFPTEEAYKIHENSYHLHPSTHTSEIYSESTKTQPNNVSVNTCYICNNTFTSISNLNEHVRNNHSSKRIQNVNGKISPKPAGSCFHCNVIFPNAQSLIEHLYDTLGTKKTNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8Q5</accession>
    <name>A0A194R8Q5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative multidrug resistance-associated protein lethal(2)03659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8Q5"/>
    <dbReference type="STRING" id="76193.A0A194R8Q5"/>
    <dbReference type="InParanoid" id="A0A194R8Q5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="245"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="506" mass="56213" checksum="3B2B0CFEEF311C4F" modified="2016-10-05" version="1">MFAAITRAPMRFFHTNPSGRVLNRFSKDMGAVDEVLPSALLDVLQIGLSLIGIVVVVATVNWWLLVPTLAIGVIFYGLRIIYLSSSRSIKRLEGVTRSPVFSHLNASLQGITTIRAFGAQEALIREFDNHQDLHSSAWYLFIASSRAFGFWLDLVCVVYIAIVTLSFLVFDQQEHGGNVGLAITQAMGLTGMFQWGMRQSTELENQMTSVERILEYSKIESEPPLESPPGRKPPASWPEAGRLEFRRVSLYYAPGEPAVLRELSFLVLPREKVGIVGRTGAGKSSLINALFRLAKIEGEIIIDGRETSTLGLHELRSQISIIPQEPVLFSGTMRHNLDPFDEYPDQVLWRALEEVELKEAVQELPAGLNSRMSEGGANFSVGQRQLVCLARAIVRRSRLLVLDEATANVDPQTDTLIQTTIRNKFAECTVLTIAHRLHTVMDSDKVLVMDAGQLVEFDHPHILLQKSEGVLRGMVDQTGRTMAETLARVAQQAYESKYPQSGATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9N5</accession>
    <name>A0A194R9N5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9N5"/>
    <dbReference type="InParanoid" id="A0A194R9N5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="834"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="103602" checksum="B6A5A72EC6EC0BC6" modified="2016-10-05" version="1">MQTGGRKSAFTGIWEMTLSERQNAATLLDNTTVTPFVYCRYYFKCFFCHQQYSNINNLLEHTLTHEMPDRATILKELIPKGKRTVKVDIANLKCKICERMFTDINQIREHLISEHNISFTPSGNGVVAYNLAPKKGQFACHVCDKMFQTFILLNRHLNVHFCNAICETCGAGFITHQRLLQHKEIHSGGYPCTNCNKVYTTNSNLKYHIEKSHQGGTKMRMLRCTHCSERFTEHFRKLKHLKEVHGITFNFECEICKLVFPSRRSLTMHTNKYHSLKTQCEVCKKNFSCITTLKKHMISHTGERNFVCKICAKSYRHQKSAVRALPSGIWHMTLAERKNAATFLHLTTVRPFTHMGSTLKCFYCKKYYSDLSDLLEHTLTHAVEDKDTILKKYIMNGKRVKATGRCVVSRKKKVSFTYSIPQRNNAELILNHSSAYPFKTRYSQVLCSHCHKEFEILSELKVHMGKYHFNADHKNVLYGLRGHLMKIDISHLECKLCRQTFLDINDLMCHFSQEHDLPVNFNASFGVLPYKYVDDHWVCVSCGKTYSNFNDIKRHTSTHFMNYNCEKCGTTFISYQALKDHQRQVKCYRTAYNPRNGRVLRPRSNAEIILQCSSAYPFRTWMSNLNCIFCRVKTRDPVFFRNHMEAEHNTYDVQTAFYKKMRKAFLNVDITDLKCKVCSITIDKFEDLIDHLKNDHNQPIKSDAQSGLLPFRLNDGSSWKCAICNNQFINFDALRKHTQSHFHNYVCDTCGEGFITESALIAHNKIPHENKYSCSRCKATFTSLNERSAHVKTKHTSKPYVCLCCDDKPRFSSWEMKKKHQLIVHSYGSDGDSYACTLCGKSFKSRSGKYNHMLRVHRRINSELNFICSNCSRSFTSQLFLDKHMAKKHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC71</accession>
    <name>A0A194RC71_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC71"/>
    <dbReference type="FunCoup" id="A0A194RC71">
        <property type="interactions" value="1999"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC71"/>
    <dbReference type="InParanoid" id="A0A194RC71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="39086" checksum="3E8FCED94D7752A7" modified="2016-10-05" version="1">MAEIEQGTFGLQVKHLTPEPPTLYKSVIPVKHNPSIIIKSKFIITQLSHRDLGWKILHRILKVYIIIRQFVKLSEVNKFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGSATVGLKSKQFAVLIALKRAVSELSAYQKKIIPIDDHIGISISGLTADARMLSRFMRTECLNYRYSHDAQMPVGRLIALVGNKMQICTQRYDKRPLGVGLLVAGYDDQGPHIYQTCPSANFFDCRAMAIGARSQSARTYLEKHLNTFMDCDLQQLVAHGLRALRDTLPNEVELNTKNVSIAIVGPKTPLRVSDETELARFLSLVEGEERRGGSGSATGDAGPADRATGDDRDPQPAVAMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCP7</accession>
    <name>A0A194RCP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nanos-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCP7"/>
    <dbReference type="STRING" id="76193.A0A194RCP7"/>
    <dbReference type="InParanoid" id="A0A194RCP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="360" mass="39779" checksum="233E252320BF4909" modified="2016-10-05" version="1">MDKISTVTSTTMNQNLIGSDEGDAIQNSLFSPLAPPFESRLNNLLQNSVQHSTLAGPRNFSQPMMSLRTDHSDAIFDDIGSRSQNYSIRSDEGDAIQNSLFSPLAPPFESRLNNLLQNSVQHSTLAGPRNFSQPMMSLRTDHSDAIFDDIGSRSQNYSINDNGDANARAQNVCNDGVPIGDTAAKNENIFDAYDFLLKSMKSAHMYISLLNPEQLAVLGAMRPSVLYEFLQGILKAKTGKRTKRLPTECAFCKNNGESEECYMSHPLKDFRGRVLCPVLRAFRCPRCGATGDRAHTKKYCPENPENSVNRSGDYQYQRRLSSASSFFMSDGVHAPAGSPPMPSDNDTGLNTHLWSSFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCT2</accession>
    <name>A0A194RCT2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCT2"/>
    <dbReference type="FunCoup" id="A0A194RCT2">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCT2"/>
    <dbReference type="KEGG" id="pmac:106712363"/>
    <dbReference type="InParanoid" id="A0A194RCT2"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="196" mass="21848" checksum="5F8CFECDD3F74A24" modified="2016-10-05" version="1">MAENVNIDLSGEINATTEKKGLQKYVNEVELLLQHVRSGAAPALVLGLLSSRRPWTQFIATENFKTPASIPRLTRRFYRNIEYFQANYLVVFLGLFAYCLITSPLLLIAMVASFFGYRKLTSGPNTWKIGNWELTKTQQYAVYAAASMALCWLAGAGAVLFWVLGATVTVVALHASFFDAETLPPTDEQFPMIEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCW0</accession>
    <name>A0A194RCW0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exportin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCW0"/>
    <dbReference type="FunCoup" id="A0A194RCW0">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCW0"/>
    <dbReference type="KEGG" id="pmac:106710547"/>
    <dbReference type="InParanoid" id="A0A194RCW0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="116"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111321" checksum="A56B1C2C86686B00" modified="2016-10-05" version="1">MNVEAVNGDMAGEVGLIADELSRAVELTLNAAVSHDARNQAYNACESFKENSPWCAQAGLLLASGSQYSAVVKHFGLQLMEHTVKYRWTQITQAEKIFIKENAMKLLYMGGWETGHLNDALARVIVEMIKREWPQQWPTLLAELSDACSHGHLHTQIVLHVFLRLVEDVATLQTLEQHQRRKDIYQALTSNMAEIFAFFMRLIELHVQEFREKTAAGDYAAAASNGRVVQVVLLTLTGFVEWVSTNHVVMNDGRLLQILCILLQDEVFRLPAAECLLQVVNRKGSTKERKPLMILFSEDAISSIHRAALASIGTADEKQYLFLKKLSQVLDVVLSRLLQAEPRPCAAAGLRLLRRCVEAQPRSPLLLSLLLSLISALFVFLSCAYSQLAGPGVGEAGAELLPRVLDKIFAALVYEGEPPEDRRSRSVKNVRRHAAGLLVKLGSKYPLLLLPVFGRLNEMCSAALARPDLSAVESVTIQEALLLVSNHFCCYERQTALVAQVLGDCSSRWAALAPHVSSAEALARLVGLDAPPADDEERGRARSTLLHALTLLLGVVKRTHVPADPDKASRGGFGAGVTSSGNPVWRNPCSAHVLPLLPHALALARALHELHEPRAATLRHPAHRRALLPPPAERHNLLGLRDDAPPAPTEPQDRMQNYLHTLHDNVCHLVGAAAASLGRELYGAAGLARFVVGALLHAPACLPDHWLRRVLRAALRPLLLHCPPAHYADVALPLLEHLAPFMLVHLSQRWEYVTSLYESGKLEEEGGSESQEVLEDMLVRHLTREHLELLKISLVDTAGGGGGGGETGDMEEESAAPQRAPEHVSELGALVLAVPVLGPTVLHTILRALTWNDSTSSLRACALALPALRAALAAGRVGAADASGALAAVLQALRTHGQHDANQAALLALAVQSYEMLRPRFPGVVSVLRAIPDVDAHDLQRLDDKLAAHHTKPPKIDKSKRDLFKKITSRLIGRNVGQLFKKEVFILDLPTMHVAKEKARSALDATEGAGLESLFAPRAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REG4</accession>
    <name>A0A194REG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REG4"/>
    <dbReference type="InParanoid" id="A0A194REG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="10266" checksum="39EE8B4EE00FFFE1" modified="2016-10-05" version="1">MARRGESGQMGQELMLRAQVAARVAERGAATQAGRAALRQHAVAAVLGEPHLPCHGLPDALLLQDSCYGVLYNRSLVDRRLGQAADSACGNGLSKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFD0</accession>
    <name>A0A194RFD0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFD0"/>
    <dbReference type="FunCoup" id="A0A194RFD0">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RFD0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="550"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="894" mass="98927" checksum="89C67699418DABCA" modified="2016-10-05" version="1">MYQVPRKSYREYHADLYPDTSGAVTYVNADMWLQHQERPVPNISLHPDHNNCTQVHRGNLEEVVKAILAMPPLKKNEPKPIVTQIIEEQPVLPKPQVPEQREDDRIDFINVKDMIKGMERQTVEPKEYTKETNGFQKKITDNGHDCTEKNEEEFVKSEECNRLEKIEAEERVLEKNDSTDSAEGSLSRSNSLINGVPIQAPKPLPRSSISEAGSMDEHSEAPKPKPRTTTSAVGYKPRLGPKPFSASSSSEEFSFDKVFSVPAVPGTVTKSDSMTSPVSGAAVTPATSTPVAKEEEKEKSLSPTSDVEPAAKEEYTNGKSDTSLEEEVSSSDSGYRPKTPSTAERRKMFEATDGNQSIAERRRAYESRSVSVANESEAPPSPAPLRRRDSLKSRKSPEREEKRSSVPNVTTKRTSTVFGKVSKFRHLKGTPGHKSTHVENIKNISRQISGECNGFYANGVRCAVPISGGGGRVGIVELPRGATPIAVAPRPHPSGLHPHALLHAAPLNDCAWDPFCAQRLLVACDDGMIREWILPENGLQESTNEPNRTFSAHPDKIYILRFHPTASDLLTSAAHDLTIKLWDLSQPEPQPAITLTGHTDQIFALDWSSCGEYLATLCKDGLIRIYKPRETRDAVRSGPGPAGSRGGRVVWALNDTHLVVTGFDKVSERQILLYKACDLTAPLCTVGLDVSPAILQTHIDHDSATIFLTGRGDSTIYCYEVTSEPPYLCALSHHRAPTLHQGIAFLHKNLVAVEKVEFARALRLTNGNIEPLSFTVPRIKSELFQDDLFPPTLVTWEAWQSARDWLAGRRATPRTASLQPPGMQPLSEHTPSPGSRDKAKETQKPKPDLIKSHVPIDNKDKQDSILKSMSARVQVNLKLEQDSMEGVDESEWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGC8</accession>
    <name>A0A194RGC8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGC8"/>
    <dbReference type="InParanoid" id="A0A194RGC8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF61">
        <property type="entry name" value="PROTON CHANNEL OTOPLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="615" mass="69178" checksum="1D1C88D02A0AEFE7" modified="2016-10-05" version="1">MVKNKEKSNQNGAGGKEWRERSEPLLAVPEDESEHPPHILPRLSVVLPCSSTSSVDHAPTKPRSTLSHGDESMTVVLSAFYAKLLIVLGLALPVTSTIQNELVTNITSDIFTMYLYVVSMLFLAYTFYHLSRVKKNKDVNVKRTRYGSFYLHIGVAGFSVGSIIYSCLQIAEYFDLSGDCQIIIVALKPTLRILFMVAQSVFIFSYTDILDPMRGVVLDRFGLMHLIATNVCEWLNVIIQETRDDIIAVAYNSLPFIRYTTIDKPTKSPIATSDKGNYLYQDYNSTSISKNITIPVENWSCNISDIITPLIRSANPYLRPCGVEYSLLCSIIIVVIWNDICTVPGSKPLNDVNSNGIYTKDVKQCCTRIKSNNHFSVDCGSAHKGLFMGIAVLAGTIVSLMLFNGLFQKDKHEELALLQINIWETVLFVIMTIGSGACIQRMRLLTLRKISTTMPLEHALLLVTQCGVYLYYLFQIIGAGFLIQRYPEARIIAPLCAIIQSSCQSLLVLDAWSRRCAGTGGRPGRQLVTFLLVGNFALWLLNRVKNARAEYHPLQMEFFGVWAWTLITHVSVPLLVCYRFQATVCFYEIWKNSYKTKNDASIRDDNEFELKNHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGU8</accession>
    <name>A0A194RGU8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitelline membrane protein Vm26Ab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGU8"/>
    <dbReference type="InParanoid" id="A0A194RGU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9005" checksum="1CC2A9216D38B73A" modified="2016-10-05" version="1">MGSKLVGADAGYKYFIFACFLALAAAKPGVLPVAYTAPVAAAYTAPVAAAYTAPLAYSAYFAYTAPVAAYSAYTYASPYAAYYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHC9</accession>
    <name>A0A194RHC9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Mocs2</name>
        <name evidence="7" type="ORF">RR48_13838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHC9"/>
    <dbReference type="FunCoup" id="A0A194RHC9">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHC9"/>
    <dbReference type="KEGG" id="pmac:106708823"/>
    <dbReference type="InParanoid" id="A0A194RHC9"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="40573" checksum="AEDE6F3C61DF6063" modified="2016-10-05" version="1">MDHLKLTEDKLSVESISELVGDSSCGAISVFIGTTRDNFEGKKVVKLEYEAYEAMALKAFKDICNEIRSKWPAVHGIAIYHRLGAVACREASLVVAVSSAHRGPALAAAAHCVDRLKASAPVWKREHYAGDHAPLWKENPECSPPPPPHRSPCPSPPHSPDDTTDRNLVQINVSNEELQQRIQNFIERKRAQVDLSNIVDFIPGHCETETQDADTCARVRTQFVKRSDSKGHLKIRKVHNEWGPQLSRGAGGAGREAGGAGREAGGAGREEGGALPGGVAERLRAAEEFLSVAPVGRDVYRRLKQVEDRIAELQAISPEYAHFWKLKSEPAEASPEAAECAFSADDIARKIEQLERQAAAASPTSLTSLTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHS6</accession>
    <name>A0A194RHS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chymotrypsinogen 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHS6"/>
    <dbReference type="STRING" id="76193.A0A194RHS6"/>
    <dbReference type="InParanoid" id="A0A194RHS6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000082">
        <property type="entry name" value="Plasma kallikrein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040479">
        <property type="entry name" value="CLIP_SPH_mas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF140">
        <property type="entry name" value="BCDNA.GH08420-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18398">
        <property type="entry name" value="CLIP_SPH_mas"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="546"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="790" mass="85888" checksum="66439238FE368B9D" modified="2016-10-05" version="1">MILCRSLYGVSGYTFVFFRRGCSGWPVGGEGGDFSAPLALDLFESLDTQVETRSCPGVCMHTLTALICSNVRDDADCPSGMKCCMDEPLDNDTAITTRRPFTTRYTTTESEEDETTTLTPDRHKDSGNIACPDVCVVVQLAQYCQAYLSSPGLCASGRVCCVARDFYGDSPPDDLVVPNEKHQHQHHHTKKPSTALTTTSPPKKKTAVSNKERECRGECISGLFVLLCDHVDEQASCSDGGTCCITDNKDTTTRRPTTTPRPTTPPQLPRCPSFCLPTVMAAFCKYPSEINAHTNCRLANMFCCDNTRAAKTPRPTTPRPTTTTPPPAPPAPADPRPDCPGSCVVPLLSFTCFHNAEITDVFKCKKSGTQCCAPKSKIIEVVGTPERNDSYPLTTTTAGYKHHALTTNEIVPHVPHVPQVSHVPQHTTPIDRIAYPYEPNYGTTMMHTAEKYNKYVCGVKGTSSSAGRVMGGEDGMPGEWCWQVALINNNNQYVCGAALVGTQWVLTAAHCVTKYVMKVDRDVWKSGTYCAIRPTLRSSCDRAGRVMGGEDGMPGEWCWQVALINNNNQYVCGAALVGTQWVLTAAHCVTNIVRSGDDYFVRVGDNDLTRKYGSPSAQTLLVATTYIHHNHNSQTLDNDIALLKLKTKAELKDGVCLVCLPARDEEHPAGKRCTVTGYGYMGETGPIPLRIREAELPIVNDSECVRKVNAVTEKVFILPSSSFCAGGEEGNDACQGDGGGPLVCQDDGFYELVGLVSWGFGCGRQDVPGVYVKVSSFIGWINQIISVNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIT0</accession>
    <name>A0A194RIT0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Connectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIT0"/>
    <dbReference type="STRING" id="76193.A0A194RIT0"/>
    <dbReference type="KEGG" id="pmac:106708395"/>
    <dbReference type="InParanoid" id="A0A194RIT0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051295">
        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF318">
        <property type="entry name" value="LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265237" evidence="6">
        <location>
            <begin position="20"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="589" mass="66125" checksum="682FD0FC8F218A4F" modified="2016-10-05" version="1">MTAWKIITLTCFFLLLAEAKPNLNDIGENNEVIPSICDPGFNTSDAVQCFCAKDDHNIARSAECYPTIEEISQDDPAWSKFDSIKNAVRISLTNNRGISFKFIPKNALKHTHNLLRLDVKYANVKVIEPFAFANLSLLEDIKLSGNQIEKLKPNAFSHLETLKTISLDTNNIMEINRDVFVSLPALEKLFITNNKVTIIHDKAFIHLTNLKELEIDRNKLFSLNSETFSGLGKLKKLDLSGNNLEVIGDNTFKPLTRLISLNLDENKIQMLDSKAFHGLSKLQSLSLAHNELSDIDNVNVFQGLTSLTALSLKGNRISTLRQEVMAPIMDNFYQNIASLDIEDNLFPCDCRLEWLMVLMNKTESASLKLILENFKCIPDAKLRDRWTKRVELEKNSQTFDGEEPSTQSQDYEYYDDAELNGKLFYTDVRDLLHCNSPTGKPLADSLDVVKKTNTAAGISPLDPEANDAPNNPGYFDESIFKKNKTKKSLAAPKTDNSEVANQEIKDDKPNISTTTRLATVSAKPMEKRTEETKDMASDEAKSDNAIAHRSVQEKGDDYSDFFTNGQDSTLGSFKAVVLMSVLNVRFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ30</accession>
    <name>A0A194RJ30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 22 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ30"/>
    <dbReference type="InParanoid" id="A0A194RJ30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="491" mass="54764" checksum="A9795026FF77B594" modified="2016-10-05" version="1">MILTKVDTDDPDYVESCKEEMKKEPVGSDALERVLYHVGEMGRYQKLMFLSMLPFALLFTFIYFGQMFITATPQQHWCHVPELAHLDMETRRNLSVPRVGDGWAQCEMYAANWSLVLDAMQPPEPSTPKLPCQHGWDFLLRDIPYQTVVSERGWVCEYSGYAPFAQTMYFVGSFTGGILFGWAADHFGRVPALVGANLIACVGGLGTIFTKGLWDFVFCRFLVGMAFDNSFTWLASRGKVNQAVKVLKKFERINRTKVPQDVMDDFIVSSSQSRESSESIIEVFKSAPLRKMMLLLMVIYMGCAMIFDGLVRMSEGLGVDFFLAFTLASATQIPSVGIVALLLDRLGRRNFTMGPIIMTGIFTITAAFVPKGLPQMILAIGSRFSINMACTASVQWSTELVPTGARASGLSLVHVSGYVGNMLSPLIVYSTYSKHQYTLTVSSFCFLLPETKGRSMPQTIADGERVMRSHTLCGKAEEETDLNEKEKTLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJW8</accession>
    <name>A0A194RJW8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0488 protein CG14286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0488 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJW8"/>
    <dbReference type="FunCoup" id="A0A194RJW8">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJW8"/>
    <dbReference type="InParanoid" id="A0A194RJW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029274">
        <property type="entry name" value="DUF4615"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13602:SF2">
        <property type="entry name" value="UPF0488 PROTEIN C8ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15393">
        <property type="entry name" value="DUF4615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="25011" checksum="938845EF6861D5AE" modified="2016-10-05" version="1">MPKPVKLHSKGKPNSIQKANKLDKDNDNKDPEEATREFQLQLCWCIQQLERSLHEKKGNEKHLQEAWKVLTILKNNNQPIIRKRQLMRTHFGDYRAKMAAEEKKLIKMASKFKISESPVPPKATFLRKSVFSATGDESFRFNFNIPPENLDNGNTNVNSDNTDNINSTESNDNQLTANVASVEKNDDKNEVSAKSEQKNFKFTFSSSSFKFNFPIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK15</accession>
    <name>A0A194RK15_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK15"/>
    <dbReference type="FunCoup" id="A0A194RK15">
        <property type="interactions" value="1527"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RK15"/>
    <dbReference type="KEGG" id="pmac:106721531"/>
    <dbReference type="InParanoid" id="A0A194RK15"/>
    <dbReference type="OMA" id="TACIWGV"/>
    <dbReference type="OrthoDB" id="9984207at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="466" mass="51948" checksum="4F9C97AB66C81610" modified="2016-10-05" version="1">MKSSKRRLQALTEGSDGLPNYIKMEDSEISLPPALRSRLHELFSQIEKEFDLLYTENLNLQEKIDFLSEKLERESYIGDKQNQDLIEFETAGKNSKVKLSQSNSQKVKASHKLRVQTSKIVSSFKAPTYNCQLVREFTGHKDGIWDVSTARPGQALIGTASADHTACIWSVEWGKCLLQYTGHSGSVNSIRFHPTRDIALTSSGDNTAHVWQAAVNWDLPRGQSSEEELDGGGEESLGEGGDRPEVLRTPLTELTGHIGVVVAADWLTGGDHVITASWDRTANLYDVETGDCLQILTGHDHELTHASAHHSSRLVVTASRDTTFRLWDFREPIHSVSVFQGHTESVTSAVFTREDKVVSGSDDRSVKVWDVRNMRSALATIRSDSSVNRVSVSGGGLIAIPHDNRQVRLFDLQGQRLARLPRSSRQGHRRMVTSVAWAEEISNINFFSCGFDRRILGWSIQPSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKV4</accession>
    <name>A0A194RKV4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable ATP-dependent RNA helicase spindle-E</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_12020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RKV4">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKV4"/>
    <dbReference type="InParanoid" id="A0A194RKV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="432"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ18172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1559" mass="175349" checksum="77E2E9EB8B831CEA" modified="2016-10-05" version="1">MEELRSFFNNPCPSNAQVKKLRGPITGGRRITKEDTINELNKPEQHRHSVLASGTDYAEAIKKKEMENYLKYEGNRDTFQSFAGGLDSLEQLSSYSYSMQNIEALTEEAMNEVYKKYSFQRKEDTNNLAINEYRQQILSSISAYPVVIIEGPTGCGKTTQVPQWILDDSFENRRPCKIVVTQPRRIAAISIAKRVAQERGWDVSGVVGYQILSSISAYPVVIIEGPTGCGKTTQVPQWILDDSFENRRPCKIVVTQPRRIAAISIAKRVAQERGWDVSGVVGYQVALEAKVSSDTRISYVTTGILLQKLVSAKNMNEYTHVILDEVHERGQEMDFLLLVVKRLLYTVSPHVKVVLMSATINRKTFADYFMIPTPMGLQTAISIKVVKKDPMFTVKTFYLNHLNKFGSILDKITSSKNESPGIPSEMHHLVIKLIDAFEQIDEKEENFACRSEADLPSVLIFLPGINEIEELYDCLTNSELRSKMSEKTGTSKTKWWVLPLHSTITADEQVRVFQRAPPGQRKIILATNIAESSITVPDIKYVIDYCLMKVLVADTATNFTSLQLSWAAKANCEQRAGRAGRVRDGRVYRLVLERFYNDLPDECPPEIVRCPLERLVLLAKMLDMGPPSDILALAMDPPDMSNIHKTMLVLKEVGGMKKTINDEWCVSDGDITYLGRIMAKLPLDVRISKLIMLGYIYGCFDESIIMAAAMSVKNVFNSPFREKLNAYNSKLTWADGSTSDCIAFLNVYKVWNHLRKLNYFKQPGSEGQWARRFYVQVRALRELDDLVRELRVRLSREGLDTNAVPSPWAKHEITLVLKLIIAGAFYPQYFVHASTDECREREAVRVLGGLNPRRSLYFTGWPTHQPLAPYAPAIRNTVRRLLGDDPRVSFDVGSRKIFLTFSDGSDETKSTEKTGDPTIPGQVVLPVYKAVKARQIRTDFRIPLLPIEKANELAAAHERANTIIDLDKMVPRLPEIDDTHFPLKLSQYISVSKFWVQYDDESTVAELREIEAALNRGTLLASAGGEKPGVLRAAPYVSAAGTAFYRARIVNTLPRDMLEVLYIDYGSYGRVSTCSVRELPAGVCSNTPPLAMRCSLTGVAPAPLLDHHAHWTPAADHLFTTLITRGRLLGKVYSVVNGVVSIELFAEHGKTSVNKALLDKGLAVPCEESYESKLNHDVREMANGLNMVQKRAYNKEQIEAAFYHMNEIDPPNYKECDTDVCLKGPFSPLEISVHNLMYAGREKQVNIEWNSVNSVLLDTEPQEIYERLLVAAQVGQNEMGSTLTLHHTTLMPNIPGLPAIIALLFCPALLVAAQVGQNEMGSTLTLHHTTLMPNIPGLPAIIALLFCPAAELRRDERCTRYVSTLCGLGSHDDGRPYFPEHDILVNIDVDLDVDDIGLINHVRHLMDYMMFCSEGQDTPTADDEFHPKVPKFIREDIMKLLRKRRKHREPCCVANAWCWRSADESELLEISVPGMAERALVFSLHRPLELHATPRTDLLRLHAANQALYHMLARTSSSSSQELTCELCNTGPLPAPAMRIHLYSNMHLEKEDDLRDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKX7</accession>
    <name>A0A194RKX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKX7"/>
    <dbReference type="STRING" id="76193.A0A194RKX7"/>
    <dbReference type="InParanoid" id="A0A194RKX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="231" mass="27064" checksum="23B9C30416DF7AC2" modified="2016-10-05" version="1">MIHKWFHKFVRRTTKPIPEDQALLWKRRLSLAYGFAAWNAFGLLIYAIYQGKADWAHYYGLKTDEEQAIPPARAWANTLGIKNAKVYRISGFKKVDEYDIVDGQEIDINLEKIHKWFHKFVRRTTKPIPEDQALLWKRRLSLAYGFVAWNAFGLLIYAIYQGKADWAHYYGLKTDEEQSIPPARAWANTLGIKNAKVYRISGFKKVDEYDIVDGQEVRHKKPIVDSEELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMX5</accession>
    <name>A0A194RMX5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMX5"/>
    <dbReference type="KEGG" id="pmac:106708254"/>
    <dbReference type="InParanoid" id="A0A194RMX5"/>
    <dbReference type="OMA" id="CVMVKFA"/>
    <dbReference type="OrthoDB" id="7265343at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="69"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="284" mass="32135" checksum="5833FE8BFE5F5836" modified="2016-10-05" version="1">MKAACIILTIIIFVAIMAVCVMVKFATDITVEDRKREYMPGNEGVYEVAKSIGVFALNDNYTLPIAERFPYVAAITRNSSDTWSFACFGSVILVKWVVTSAHCRKPGATHRILLLQDYIKNYTHTYPILFWRINEKYNASDPSGKNDIAVAKLNLDSYPAIAKSSTIDSNEAKDIEANVWKTVSTMSKQVYLTNNFDKFEVKIAKNHKCFESYGVKIDDSLICVDMSDYEDCFIHEFGPLYSGDKLVGILAMKPKDCDLKLLVFTNVSYHAKWILRITHTPLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPF7</accession>
    <name>A0A194RPF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">28S ribosomal protein S30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPF7"/>
    <dbReference type="FunCoup" id="A0A194RPF7">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPF7"/>
    <dbReference type="KEGG" id="pmac:106717928"/>
    <dbReference type="InParanoid" id="A0A194RPF7"/>
    <dbReference type="OrthoDB" id="6041973at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039982">
        <property type="entry name" value="Ribosomal_mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="548" mass="65191" checksum="5D02D74727A477DA" modified="2016-10-05" version="1">MHLLKLNRNIPKFQLWTRRYSHAVLHDENEYTDTPVYPPILDMSLQGRKLRERQSVHEKIRNLKTVEEKQIALNMPRYYGWKCVMFNKNRIPYNALPMVQCYTRTHFKTVNSLPDAYSETNPLAEQVVKETKSIIEDIIAVESENVRHIHNNPQEKSEEQLKEENITKNIVRQINRVICNKLADQLPHVLSAQIDYEPRHEAFWFVGGTDVPHNVIQWRKQYKWLHDRLEEPIDRPVQYIGTPHLAVRSQLPLKPIVPYEEATNPDFKVPKFTYVPESVGYYTEFRHGTNIPGFWPGDYDEFGLLSYHGRDHMLSRNESYGHEDNINALHSQALKSSFGWLLAQANYQGFTTYNDITYPLVTQTVITNAKLWSFYVYQMNTITMHNEQMDENPKHNICFGTTPLQLYDTIENGQVKGLNEDVLKMLVQFYLNAPEEREHDMKPYLGKDEQLIADIEDDNKRCWLESTYKHLVSNRPKHNLIPEIYLWERIYKIQHKTRFFEAKRRFFECGINPYKRRLNEHLPPYIPKALREYPRSKKKFERTYYPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPX2</accession>
    <name>A0A194RPX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modifier of mdg4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPX2"/>
    <dbReference type="KEGG" id="pmac:106718124"/>
    <dbReference type="InParanoid" id="A0A194RPX2"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF99">
        <property type="entry name" value="BROAD-COMPLEX CORE PROTEIN ISOFORM 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="48190" checksum="5B07B001E42D34EB" modified="2016-10-05" version="1">MDQQFSLSWNNFHGNLSKGFAGLLGKGEFVDVTLAVEGHLLQAHKVILSICSPYFKKMFQTNPCQHPIVVLRDVTLKAMKDLLQFMYHGEVSVKREDLTSFIGTAEVLQIKGLTNKETDDEEEKIKDVSKQNLVHQNSSPDPESCTSENYDNSPNEIPESNEHEVMKQRQFIEKLQRLSHLKRKSEEFLQSAYYSDILNTEKRAKINDKMAYSKVNNLLHNSNYDNFKNVYDETPIDITPTLNTSVHNDNVDKDEECKEQSANQMELKTECDEIDIVVTDPAICTTPKSYEGSRDSKNNSTVALEYQSPQDNTTSLNSLFLDLKNLVNGKVTNAMLRINPNEEFPRPMLEHRLITIPQKEDGKKKYPQRSCRLCWKLGKRRDTRFMCSACELPFCKSPCFEVHFNGVFKVSQLQGDYFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR12</accession>
    <name>A0A194RR12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger and BTB domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_07433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR12"/>
    <dbReference type="STRING" id="76193.A0A194RR12"/>
    <dbReference type="KEGG" id="pmac:106714311"/>
    <dbReference type="InParanoid" id="A0A194RR12"/>
    <dbReference type="OMA" id="FVCELCH"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="324" mass="37034" checksum="09BCDF62520B6083" modified="2016-10-05" version="1">MQNNPQELSWQAIQAIVGVKLPPNVLRFDDIGFHLVNNSVSSAEDSDSDVEIVENEWESDNNISSKPENSDNEKTSPDREQSESPVLHLVEPDNNNSDKVSLDYRDYLVKMDTKDNSDVDQMIQGQIDDTDSSNGNVLSIENYLEVTLSTDSEASHTCSRCNQIFPSEQLLSAHECSAKPTEEKKYPCHMCSEKFPSYWELRKHINSHFPGMLDSKSSFCHLCQKDYTKTGFMNHLRKHTGERPFVCELCHKAFSQSSSLSIHMKFHLNVRKHACTVCEKKFVTKSELSRHMTVHTKQKSYYCGVCDKAFTRSDNMKKHEKTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRD7</accession>
    <name>A0A194RRD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose 1-dehydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRD7"/>
    <dbReference type="STRING" id="76193.A0A194RRD7"/>
    <dbReference type="InParanoid" id="A0A194RRD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="27224" checksum="BB9CE0BFC09327D9" modified="2016-10-05" version="1">MDFNNKVVIITGASSGIGAATAIAFAKQSAKVVLVGRNEEALNLNASKCEEAKGIKPLIIKAELTNDEDVKRVISTTIENCGRIDVLVNNAGVGISGSIRDGIEPLDLAISTNVRPAYLLASLATPYLVQSKGNIINVSSIAAFKPIKDVEFLPYCMSKAAFDQFTRCLALELGKDGVRVNSVNPGATKTNFMAACGYNKDQMEEIFKIREQSVPLLKMVKSEEVADLILYLASDRASSITGSTFVIDNGEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSP5</accession>
    <name>A0A194RSP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSP5"/>
    <dbReference type="FunCoup" id="A0A194RSP5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSP5"/>
    <dbReference type="KEGG" id="pmac:106721208"/>
    <dbReference type="InParanoid" id="A0A194RSP5"/>
    <dbReference type="OrthoDB" id="29444at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF9">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="16"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="359" mass="39055" checksum="DF0A7B7E7B47E500" modified="2016-10-05" version="1">MAMKEWLQWLPPPRSLLALLLAVTGFSSRLFASYVTHSPTLLVDTCHSLCRLFGLITTLLAYKYERADEGAGREGRLRNTFGWARIEVVGRLSVHVLFASFAFSLVVNALQLGVHSSHVQPPRYPKVIIGTAVLGLLLYTINYMLLAGRELSYSRRLSMTEGGGVVLKTGSAEPVLAHAPIDIVSSLFAIGAGLTTEWEPEMASIADPALSACAAIVLVIFNYPFMRSAGLVLLQTVPEGVGACELRAAALRVPGVLAIHELHVWQLHRDKIVATAHISYSSHEDYLRNSELVCDVFKRHGIGLVTLQPEFTLTSISGTEEEQKALVDFANTACSCPCAKECTAPRCCASPLKPVITRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RUK6</accession>
    <name>A0A194RUK6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Glutamate receptor, ionotropic kainate 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_07420</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RUK6"/>
    <dbReference type="FunCoup" id="A0A194RUK6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RUK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000106">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000134">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000061">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000147">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265409" evidence="16">
        <location>
            <begin position="19"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="412"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="422"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="946" mass="106364" checksum="CEF3A09BD670CC04" modified="2016-10-05" version="1">MRGTKIIFLMLLFGHLSALPDTIRIGGLFHPEDDKQEVAFRYAVERVNADRAVLPRAKLLAQVETISPQDSFHASKRVCHLLRSGVAAIFGPQSAPAAAHVQSICDTMELPHLETRWEYRTRRESCLVNLYPHPAALSRAYVDLVRAWGWKSFTIVYENSDGLVRLQELLKAHGPTELPVAVRQLPESHDYRPLLKQIKNSAESHIVLDCATERIRDVLQQAQQIGMMSDYHSYLITSLDLHSVDLEEFKYGGTNITALRLLDPERSDVQRVVRDWVYDEARKGRKLQLGHTSAKTETALMYDAVHLFAKALHDLDTSQQIDVKPLSCDAEDTWPHGYSLINYMKIVEMKGLTGVIKFDHQGFRSDFTLDIIELTRDGLQKAGTWNSSEGVNYTRSYGDNQKQIVEILQNKTLIVTTILSAPYCMRKEASEKLIGNAQFEGYAIDLIHEISKVLGFNYTFKLAPDGRYGSYNRETKEWDGMIRELLEQRADVAIADLTITYDREQVVDFTMPFMNLGISVLYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILARFTPYEWHPTHSSDGEKLENIFSLANCLWFAIGSLMQQSCDFLPKFSPYEWDSPGNCIDEPQVLENQFTLLNSLWFTIGSLMQQGSDIAPKAVSTRMVAGMWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTKIKYGALKGGSTAAFFRDSKFSTYQRMWSFMESARPSVFTSSNKEGEERVMRGKGAYAYLMESTTIEYVVERNCDLTQVGGMLDSKGYGIAMPPNSPYRTAISGAVLKLQEEGKLHILKTKWWKEKRGGGSCRIIDERDWIMQDETSKSSSTANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVDERASLCSEMASELRSALKCPSTGSGGGPANTRDGAGSPYLHYGFSTKSQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAU4</accession>
    <name>A0A0N0PAU4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminin-like protein epi-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461158">
        <property type="protein sequence ID" value="KPJ08066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAU4"/>
    <dbReference type="STRING" id="76193.A0A0N0PAU4"/>
    <dbReference type="InParanoid" id="A0A0N0PAU4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="728"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123203" checksum="DA50FE17D8951537" modified="2015-12-09" version="1">MGLPDLTEVRAERDVLQTRMSEQALRISSLSARLTRQRHDADALAHAAHSHLGVQLHDANAEVQRLKEELETKDKQLARLKQSLEDKNKAEHATYGDSGNMKEKVSGLERELAAAQQRGGQLQTQLEALAADNRRLQRALAQHQLQLGDFLALKLEEDEPDQRSERGEGKVSARTLSDIVSISEFDEQDLQMRRAELRPHEPSPSAAPLPAADKSAADRTLPPDTRPHNVTSLHLDHAHSHSHSLPHSLPHSLPPQLTSTHNGEEQYKRNVNETTVFGKPDLFGDHKPSPLNILDNCSLYPNRDVSDSRNVSVEPKKIDFSLEPTDNKTQEEEFASLRELGIELDLRQENFPDILTQLKHEVKKARRELESCKSELKNAEEQLCEFPALKEEVDELKALLENTMATMEKDKKFYENQLENFSTNKKQLEQRLAELTQEVSDKSKDLHLLKEDILRRENMILELAKEKRNLTNRLNELETKVDELQSRNEALQQYEMETHTMREKIKELEKLEQLVSEKNQQIDSLNQHLDRLDDLQRNLNDKTEELEKLKVALHQKTKELYQVQATVSSLTRDMERVTEENKELNHHNKELKLKLSKLEKEQENASLRLQNSENELERLNSINNELSSKIEEIKVINDQLKDKEAEVETLTEDLNAYHSEIRSLKEQLEIVSRSPSPGSAQAQAQGEERRRQLPAIRKQISLLQHELDFNKKELNCKAFELAKAKLDVSELKNNASQTAKLMADKEAQNEELVQQAAALRNDLRQLADEKHQLSQQLDMLLARLREESNVSEIRAKLREKAESCHELEMELHDMRDRVEGRGTSRSPTAELERALRDQLHYSNALDDHIMDQILSASSEEHEDIPRLALNTSKSSSSVASTSSERACRLRAQVQQLQLQVEGLQARLQDKDALIAELNRIRDKLVQDWQTVNCRYEAERDNSGRLQLLLDAQKDTAESLQNQDSNMIQILKKRLESAMQSEGELLEREQRLRRRLAELEAGQPAPREHLHAQLEVVEKLKGEVSVLRSKLECERARADELAAQLQLARSHLEDRTRTAADLRAQLAQLKRYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAW4</accession>
    <name>A0A0N0PAW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAW4"/>
    <dbReference type="InParanoid" id="A0A0N0PAW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="338" mass="38760" checksum="FCC036E07569842C" modified="2015-12-09" version="1">MNIPLINPDNVLSSYVFFRNALLSSATKSIPLKNSARCKIPSPPWWDSECTQACQSRSEAEDAYAAAMTSENFISYQRIAAKTVRLLSEKKRSGWLRFCEELSPISPPSHVWKNLRRFRCSYSSRSNDTNDPSDWIDHFSCRLAPPSVPSLEETSPSALSSNSTDDFDSPFSWEELSAVLESLSDSSPGIDGIPSGTNSSSPTPERTVSLPNLDKSIPILKPEIVIEERRWYPYPMIIRHYIEKPKSSEKFTALKKWYKSNQEKRRKKAERKKDMQKILAEKERIERERCLKELRRLHSHHQSLCCRSRSLPTFGKFSKPEKSCKISYKTRATTAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB00</accession>
    <name>A0A0N0PB00_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461107">
        <property type="protein sequence ID" value="KPJ09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB00"/>
    <dbReference type="STRING" id="76193.A0A0N0PB00"/>
    <dbReference type="InParanoid" id="A0A0N0PB00"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="39156" checksum="817D1B069FA06EAA" modified="2015-12-09" version="1">MDDTPLSINSEGDMDDLMVEDELGLVNSSDPDLHLELVQLKMERIKLQEEKLECKRMMILNRAGRKSVPLSSKNRSVLPDGRIVVRTVNDRPNEVTDSESFGVGSGDAVDNPMQLKIPALQRDASRACVSCGAPADAYCARCAVTPYCSAACQQRDWRARHHAVCHNLARLAEGNARSTMQASPTNVPTLHSTAPLRRPHSPMKNVRRFQNTEEDDGSQARKLPLNTNTDYQNGQISNKSQDRAGNRYQNKPQGSKNKIPQNNNNKTQNTKPQDKIENNSGNVPPLRRPQIRNDTEEEDWSNTKTSTPSSIVKLPMKSIKKIPEKSTDDKKVMKPLSVEDVTPTKKIVPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBR8</accession>
    <name>A0A0N0PBR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460936">
        <property type="protein sequence ID" value="KPJ10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBR8"/>
    <dbReference type="InParanoid" id="A0A0N0PBR8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17904" checksum="C41EFA43D3EEAB33" modified="2015-12-09" version="1">MSNEYNLKLNCNAFFCPYSNQDAKAAYKSGEIRDPSPPITLATIKRKLKESMIFDYEDPSLNDREKKELSKLFDAVEIMTTARARQPFNVQNMFSSLRLVERAVKKQLKEGQISESLASKFKWDKLSNRQKRDKPMYYLDVARDSVHVGLKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBX1</accession>
    <name>A0A0N0PBX1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460874">
        <property type="protein sequence ID" value="KPJ11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBX1"/>
    <dbReference type="FunCoup" id="A0A0N0PBX1">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBX1"/>
    <dbReference type="KEGG" id="pmac:106714471"/>
    <dbReference type="InParanoid" id="A0A0N0PBX1"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="34154" checksum="17406D6721572DDD" modified="2015-12-09" version="1">MPTFLTPGRHGYNVRFSRRRPDSIAVATSQYYGLAGGGTLFFLELAPDGTTLLEVQKLEWSDGLFDVAWSGSSDGVAACGAGDGTVVIWRGGCAAALRVLRGHRSEVCSVEWPRSHILSASWDTTVKLWDPESEACISTFAGHSQLVYTAAFSPHSAATFASVSGDGHLKIWTCMEPVRPAAVVKAHDAEVLSCDWSRTESHALVTAGSDGLVRGWDLRRLTTPMFTLKGCECAVRRVQFSPHTPSVIAAVSYDFTTRIWDLKRGCEPLETIRHHSEFTYGLDWNSLRPHQLADCGWDSLVHVFTPRSLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC03</accession>
    <name>A0A0N0PC03_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutS protein-like 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460731">
        <property type="protein sequence ID" value="KPJ12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC03"/>
    <dbReference type="STRING" id="76193.A0A0N0PC03"/>
    <dbReference type="InParanoid" id="A0A0N0PC03"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="3">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="43555" checksum="2EC00B4713AA2112" modified="2015-12-09" version="1">MDVDENGTSSNSARPPTSSVSRNKESSTSENAFVLTTCTRNKDEFPKQHTSTSNNQETTDDSEIEELFVLDEIVDRPPEHQILCSLFRQVHPMLVLLDGKAPAGCVSVTKSLVFADFSADEDAHCKLQFISSKEYNYEACRRRVLSLSLAQEPAQCSGAEREVFLRTALDLGQALSVHALGALLRHLDLNWANLSLNLYGKPEFLSLKRISLADIVCIDEDTYSGLQVFSALAHPAGLRRGARGSAREGLSLYQLLGKCASRLGHAALRVLMRHPSSDLATLQQRLDVVEFFTRPENDSLMRNICSSLRYIRNVNGILAKIKALSAKPYQWKALYNTLYHAVLISELCEDAGESGGLLRDLANTDIQHLYEVTATSHTSLQTNLIIVCVNLANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC57</accession>
    <name>A0A0N0PC57_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRP12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N0PC57">
        <property type="interactions" value="1367"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC57"/>
    <dbReference type="KEGG" id="pmac:106712974"/>
    <dbReference type="InParanoid" id="A0A0N0PC57"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="129"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="451"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148790" checksum="E0B1724A60839439" modified="2015-12-09" version="1">MGKFRSKLKGKSKGKRWQKGQSSNSNPKTQKYREMAKSRFFQENLGSTGLTQQAVLKHDAMMTYGHSTGKQKSESENELAIAKDFESMSMRSGDEGSETEYTGSMRSGTFRTFQTFASDWSQCSNVSFSKLLNRFDSNNAVHKDMLAVLAAVTEVIKEQGGKETSTEYFAALMQTLKASEDDTSLVATLSLLSMGIKSVPQAVLRKQFSESATIFMELLEKNAQSDNGTLLRSIIGCLSVLLRAQEYAIWGDSSTMKVFDSVLAFALHSKPKVRKAAQHAITAILRGSCFMLPTEDDNVKVPKLHPASNRVAEYCLSQIKPEALLSGHRPVLHILTMLRDVLPVFSKDYIKTICESILSLMAHNNIYIKTCCMHTLHALFLAGGNLSGVLAAQLSRALLAARPPANDTGQSLAWAAVVQQALCCLARLDMNLCLPNLPAFVNICVTELWHSDVTDINAAATNALKALLLDCVKPALNTEECFIKNKSHIDGIFKTIGTGLDNPFNQALKHVIMTLAVCFEIGNNKLTYILGPLLKKLNERKESHNFNHHKEVEYATGCAIKTLGPEFVLTYIPLRDGTDINLDRSWLLPVLREKIINSNLKYFATEILDMATFCRKKSREYAQNNDNAKAHTYELLCNQFWSLLPSFCNNPKDIKDNFKTIARVLGNVLKDNPEFRLSVMQALRKLITCSNDNEDEKELGRFAKNYLPILLNIYMTPAKGGEGEGQRLAALETIQIYLTITDQNVREELYKNAITQLEASIDNHFQRESILDIIRLLILYQTHEDMAVLFDKWVFPLCETVIDDPRKYKKAKKDKMIEDDEVKPLKYKDKVKLIEMEHKKAYRILEEIFKCGKETCVQFVKSNYKKIKKMLMNSLNKVADSSKAARLRCIEHLINSSHFLNSESKLIKSAVAESVVCTKDINSKCRQCAFNVINTVGNLLKTQEGGMKTFLEMLSSGLSATVPRVVCATLRALASALFTFSEDMGLETVQSLLDTVSQKMLENNREVVAGGMSFLKVYTKVLPTEVLSGSLPLIFRTLSKMSEDCKRHARLEVGYFLARMTRKYGADTIEKLVPADDEVMLKRLRNVRKLENRKKRVKEQKRSQTESDSDGDMTVKGTSKTLEDILKDSDSEMEYLDEETRPKKAKKTNKAWIQDDVDEIVDLVDVSAARKITATDPTKKKKLTEEMVQKKKDGGFKTAADGRLIISDDVSDDEEDPRPSGDIDTDTDDTDNETDDKPSKLLKPGTKRRYDDILSIKSGRSIRSKASTVSKYKAGGKGIHRPLNSGASVTSAGNEYRSKKAKGDIKKKGKPDPYAYLPLSRNNLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC60</accession>
    <name>A0A0N0PC60_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_04377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC60"/>
    <dbReference type="STRING" id="76193.A0A0N0PC60"/>
    <dbReference type="InParanoid" id="A0A0N0PC60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015388">
        <property type="entry name" value="FCP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09309">
        <property type="entry name" value="FCP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="246" mass="27622" checksum="C6AD0BC84341F54C" modified="2015-12-09" version="1">MGRKQIPDLKTIIPEVKSKVLAGVSLVFSGLVPTHQRLETSRAYLVARSLGAEVAQDLTEKSTHLVAVRSGTAKVNMARRMAEDKRRKFYVVTPEWLWTCAERWERVDERLYSLQRGGQSSSRRPPAHCSSPPPAPPPLPALRKRTPSGRFMDTINPLLSFSSDDIADMDREVEDIFNESDESASSDDEEKTKKMQDDLDDEENPPEDKLLSVESDSSQGKSQDPNASSDSDEGNITFTYMKKKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCB5</accession>
    <name>A0A0N0PCB5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM179B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCB5"/>
    <dbReference type="FunCoup" id="A0A0N0PCB5">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCB5"/>
    <dbReference type="InParanoid" id="A0A0N0PCB5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135086" checksum="DC046E71EDF7F2C2" modified="2015-12-09" version="1">MQLPGTPPPPPLAPLWDRVLRARALPPDLDVDLLYVAIRDRLAHPEWEVRLHALRVLADLLPLSGNALSFPFDQVIDNLGHGSPNVRKAALDALKVFCTYCEDTECAASAIIDKCSYNNIRPLSSGFDTKVNVITGLVLSIPSVMAILKRRNPGLDMFPVFNILGDKLFESLHRDVALRSLMKLRRICGPRDYMLAFSRLDPKVQEKFRVLCDKFDEDSLDVYYAPRRSYGNRNSQHMKMNHSFNNNNFKTPILFPSDSSSDESYTTPYYTNNYGKVIIETEIKFDSDTAITMTVLEQNETESEKNTGSDDDDSIDRNMLKYSDEESEDSDVVVKKVRFGGESIKIRTPDSDNITTSEEDTNHNSMMREKNIEVVLPTTPNIINKMNEIKRETVEREVRTNHAKKSAIPLPVIYNRTRKQNGLINNNTIKSKSKSLSELYDYFNKKTDGENAKSRDTSKFALTLSEVRSPEKIPSPVETHKEVEVLHNLQRSPSVSPRRQQTRVHIEKDGFVLNLVATSPPESLLLSPRAASPLRRHYDWEELDIVPQHVCDQLHNTENWIAAVRAADQLHSALLEAGSVRRAEPAALSLVQHMWALSDAVPATRAPAEGAVCALVRGVSSSCARQLLPALITRIARDPPPAALPHALLQRLALHHLVDLIFDSDMIGIRDGKQAEAAQLRAALCVARAAGPAAVMAAVRRRLTGSARADSFCRQLRERLNKPIENIRPSHFSRSSQLPVPTRRARSTPPAAPPTKPRRLRPLPDSAPLPSVTQSKDLIMKPLSPIELSDRQGVLSSRGGRAASVSVSESVAEAPRPCTVGMRLCCCSHRRNTASVRPDLVADLPPHTRDTSSLTNTANEKEAKPIVATPIESEDKVSENKDDEKNETQIAQEDSIPSPPKSPSLQVEDVLDKSTPSLHSEKSKTDEIPTESVKETIEVQKSSVETIESLELEHLSGKSSVVSKSKSEPSSPVKSARLSPELARESSGRRSLGERDVRTALAECIMPARHEDWEAIVTGLMETEQMAMDITARAPASSWRAATRAAATHVRSLRSKVARAACSTLGALFEYRGRTLDPELDEATGALLERCADVNRFLRADATSALRRIACGGVGARAAVALARRGAAHRAGPVRAAAAQALAALVRHNGASPTLDMPVEPRTLLLRATGELLGDASAEARAHAKHLWLALAEDSRFPQMLKDAMPPTRYRAIEKYVDKLRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCL9</accession>
    <name>A0A0N0PCL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCL9"/>
    <dbReference type="STRING" id="76193.A0A0N0PCL9"/>
    <dbReference type="InParanoid" id="A0A0N0PCL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="521" mass="58026" checksum="B0CEAA6715148896" modified="2015-12-09" version="1">MEEEQENEPPKPLNLFSFLPYACEQLQAPFDLQIIPYTQFQPSLRRRRSRRSSSMTRSSAASAASSGWRRGPINIIVVEDLLGHVLELIFWRCKIIPSLLLKIISLCIPFHPNLNKISVRWGPSRGFGLKEIVKFLPESYLTEICLDDSPILRCDVHTLLEASTSLRYLSLARCSLDDEACALLADRLHYPLPAAHSLQALTLSSNRISEAGAAALAGALRSNRALRHLDLADNALSAAGAAHILRILGEFPLSDDELLGRNRRRFEYLKLRNELFLPHRKELSKALSKIEQRSTMLSARYSTKKLSPDANKENVVPIKNKQKQGSRSMSKAASKALLAPVLSWQSLSAEETLSSLSVPSSLPGAASAPRVPDATAAGRRFSLLQLKRDPLSKYKTFVRTGIVFSFGNMKLASLNLAYNRLDRSSVALLCRVLAQQAAWRDAHAYAHAQGHAHAHFQSHVHVQGYGHDEGGLLRVQLDGNPVAEDSAELRELQTLLERALSVREERPARRKPAPKHHPHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD22</accession>
    <name>A0A0N0PD22_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD22"/>
    <dbReference type="STRING" id="76193.A0A0N0PD22"/>
    <dbReference type="InParanoid" id="A0A0N0PD22"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="30147" checksum="F85B5F72CAED772B" modified="2015-12-09" version="1">MSKSYHNLQQQVDRIDHSPPMVHPTRRLDHSPTIVHHRLAHSPSVVHQIPRFYHSPPMVHRRFDQNPRMVHPRFDHNPPMVRPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVYPRFDHNPQMVHQIPRYYHSPPIVHRFDHSPEMVHPTSRLDHTPPMVHQIARLDHSPALVQHRFEESPQDGSHNPTKSWILQMHRCFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDX4</accession>
    <name>A0A0N0PDX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin complexes subunit BAP18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chorion protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460009">
        <property type="protein sequence ID" value="KPJ18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDX4"/>
    <dbReference type="STRING" id="76193.A0A0N0PDX4"/>
    <dbReference type="KEGG" id="pmac:106721196"/>
    <dbReference type="InParanoid" id="A0A0N0PDX4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF2">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857394" evidence="4">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="400" mass="41351" checksum="B2F153B7CB75F8BD" modified="2015-12-09" version="1">MAVYIAEVLFALGFLVSSLRGQYLPLNGQQYGGALGGVWGVRGAEAGCGCGSLLAGAESAAGALAAADGGGFAVVSSSPTPPYGVSVLSENEYSGIMAVAGQLPFLGTTYLEGAVPSAGAGTVAYGCGYGDVAILSEDFAGAAASLRYANDRIAPRTFGNSGFRFVLTPPHGVSVVSDNEYSGIVAVVGQLPFLGTTYLEGAVPSAGAGAVAYGCGYGDVAILSEDFAGAAASLRYASDRIAPRTFGNSGVAEIFNEAGTAFKKLSEMTMMLHPVNDAQPGGKWSDEEVEMLRACIHRFAVDLNQLSLHIKNRTISQIKRTLKKKAFEDAGIPLREVSSTVTSQQLPEPQVEPTNIEPRVLGTNPEVTLNMLNATGTEGEEEIGGIDLEFEPVSNDDVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE39</accession>
    <name>A0A0N0PE39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase-like protein LARGE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE39"/>
    <dbReference type="STRING" id="76193.A0A0N0PE39"/>
    <dbReference type="InParanoid" id="A0A0N0PE39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000016">
        <property type="entry name" value="LARGE xylosyl- and glucuronyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="544" mass="63530" checksum="8DEEFDC9197E362F" modified="2015-12-09" version="1">MNLRSKNVFTLFFRSSFGLPLGTWIVVSIVYYWWLISRINVLETQNKVFKSQLKLSQNAMRQIESDSTYKVPEIPDEAGTLCETVHIALVCMGKCTRIIMPMLKSLLQHRQNPIHFHFIVDTAADQTISKLFDTWDLPDVKYTCYNAQNSLSQVRWVPNSHYSGIYALVKLLFPDILPDTLQQVIVLDSDLTFLCDIAELWNMFRNMTDNQLFGLVENESNWYYDTAKRWPALGRGYNTGVMLLDLNKIRKKINWTKVWHSAVNENIERLKQTTLADQDVINAIIKKDPNLVYNISCQYNVQMSTKTLAKGCYGEDRDNIKIIHWNSPSKYNIRIRDADYFKNIYLSYVNFDGNLLKEKLHTCSQTEPVTYKINHSDLCSSFRAAQRVKLRTHLYYMEYTYDDIDNFDVTLVLQLSMDRLQFLERLVKYWEGPLSAAIYLSDCEVTKFESFIRDWSDTLSSRKNIGYHLVFKHDDCLVVAAFETQRYRASPPRSKAALRARLANDVAPFRAREWPRGHRATNYTKWINANAPYNVSLKLTKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE42</accession>
    <name>A0A0N0PE42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C4orf52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE42"/>
    <dbReference type="FunCoup" id="A0A0N0PE42">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PE42"/>
    <dbReference type="KEGG" id="pmac:106720844"/>
    <dbReference type="InParanoid" id="A0A0N0PE42"/>
    <dbReference type="OMA" id="YPIFVYP"/>
    <dbReference type="OrthoDB" id="8755372at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027917">
        <property type="entry name" value="MITRAC7/Phoenixin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34923">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34923:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15061">
        <property type="entry name" value="MITRAC7_Phoenixin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="8368" checksum="E6008F868EA497A8" modified="2015-12-09" version="1">MSSLKGWRYTVFIGGFVGLIGLALYPIAVSPMMDASEYKKIQKETRKNIRIEDVQPGNMNVWSDPFGRKKADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEL6</accession>
    <name>A0A0N0PEL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEL6"/>
    <dbReference type="InParanoid" id="A0A0N0PEL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026703">
        <property type="entry name" value="ERICH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="43231" checksum="EF7F09BC410C2B4B" modified="2015-12-09" version="1">MLTRQLLAHLAPSRLAIAAVSTQLRVRSARLRAARRSPPALFHPPARLALQTQRMHVFLAREHLTCKKKYAIIDLQCNTKALTTEQDSVVWLITIASSRKNNCCVDNRYDEVYFCFGVRGLCPPPPHAATRRHTPPPHGVTQALLVWKSGMVSLPSEGEYQRIGSTLALFAIANVCALKHVHKSQHVERAPRARLHDAATGLAAVAGGSRGGCDAGETGGTGERGPVGGAACGGRRAALPADCDAPDAPGELLAEFLSAILRRQYAEALRCCRLILQYEPHNATARGFCPLLRLRLRTAGTRRQFVFPIFCSSVFFQYETDDVQNENAAAVPHFKHSIHCELAAAAAAAGTARHSTAQHSTAHGCSNYRWPLQYTTYDTDTQQQPSSPPLANRQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF92</accession>
    <name>A0A0N0PF92_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coronin-1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01012825">
        <property type="protein sequence ID" value="KPJ20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF92"/>
    <dbReference type="STRING" id="76193.A0A0N0PF92"/>
    <dbReference type="InParanoid" id="A0A0N0PF92"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="11514" checksum="45369327AC1B2631" modified="2015-12-09" version="1">MCFCSQVGRIPADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKMLTVTFCSQVWQIPDGGISRTLTEPVVDLVYHQRRVGLVLWHPTAQNVLLTAGSDNQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFZ8</accession>
    <name>A0A0N0PFZ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_00766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01047188">
        <property type="protein sequence ID" value="KPJ21442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFZ8"/>
    <dbReference type="STRING" id="76193.A0A0N0PFZ8"/>
    <dbReference type="InParanoid" id="A0A0N0PFZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ21442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="11807" checksum="32D92FADBF574D49" modified="2015-12-09" version="1">MVGRAQRFVSKACRAAPLCYWRAVLDPHSFARTIENIYYISFLARDGIISIDIGLPFIKTVSSGDRERGAGSANQFIVSIDMHTWKELVDAFRIERPMMVLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6C3</accession>
    <name>A0A0N1I6C3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6C3"/>
    <dbReference type="STRING" id="76193.A0A0N1I6C3"/>
    <dbReference type="InParanoid" id="A0A0N1I6C3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7606" checksum="AAFD6699DE66CB64" modified="2015-12-09" version="1">MDVASTNGPSLRLRGGVNNHSDSKKYELNLCTSVMSAETKRLLPPTTETIMTKPFPIRGKLNKYFSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7U2</accession>
    <name>A0A0N1I7U2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7U2"/>
    <dbReference type="FunCoup" id="A0A0N1I7U2">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I7U2"/>
    <dbReference type="KEGG" id="pmac:106715533"/>
    <dbReference type="InParanoid" id="A0A0N1I7U2"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="54885" checksum="3D844BD2B50824B5" modified="2015-12-09" version="1">MSLIKKKKHVSKKNKKAWRKHCDIKDVEDFLEDQRLEERLGKFEAKKDSELFVVDTVGEEKPEVVDVKPLTLKQKKRALLPQTPKCYEVLLPTSKVQDPNAKRNHVNPVGTKPTALSKLSLKKQFEKGAYLKKVELARKNRRIVRDKKRRIKEIRNTFDKNIWGEDVLEVKGIPSTLCDDFISTEAQLHNVLPEQRLRPKPAPPKTLVTRPAVVTPHPGVSYNPSYQEHQDLLQQVVQHEEKLMKKEAHLHRVTTSLFSRLTPHEKENQWREEMSEGLPKPHNPANSPSTPSDNDTDNEYKAINPPVKNKKKDHKARRKQKERIAERERLKREKIDKKKITDIYKLRKLQTLISGKEKREEALRVKRAARRALVAATAPPALSAHRTPAPQPDLVEPAQLTGDLRNISSTVNLLRDRFESLQRRGALAASKLMMTKRKRLKAYFKPGHKVTDQDVENYLKKKMVKKTTKKAVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I815</accession>
    <name>A0A0N1I815_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TBC1 domain family member 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I815"/>
    <dbReference type="FunCoup" id="A0A0N1I815">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I815"/>
    <dbReference type="KEGG" id="pmac:106711306"/>
    <dbReference type="InParanoid" id="A0A0N1I815"/>
    <dbReference type="OrthoDB" id="5578278at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="399"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="805" mass="92587" checksum="2F8973D9F60777D5" modified="2015-12-09" version="1">MENGSHFDGDKIEKFDIKIKKKPKDGVILQLHHTVRDSHGDCRRIRFSLAVFDDNQEKLACTDNAGNIFIIDFCDLKFWKLVNHGICTALHFVPDRLDALVVASSDKFDLNFLDTETGCVYLKLSGHTDHVKHISFSKTKLNNLLTASHAEAILWELKNFTKYFTLNTHVGSQIQQIMFTPAGDHLVACFQNDTVQIWRHDTMKSVKQIIPTGLKHIKNIEFTMNGRAMVIAGLVPKLILFSMDTWKAVKSIDLTKYNIKGVQHVAFVPQMFDGGANKILAILSSNCTLHLLDLDTQELITNICPQSSSIKKFVVSPTGKYFLCILHLGEVNIYNSSLVIENSKDVMVAPEKKELPGCSTHAYQCNVQQTLANKSAVEQKMRACMDSARLRRILMQYGEYPDKFRSIIWKSLLITPKNKVAYSALVDKGIHPAYKNIEKQFTIHSTVTLKNLKRLLSCLAHWCPLFGVMKFLPGFVFPFVKVLQKDPLLLFECVATILMNQCQLWFEYAPFPPISVLAMIENVLAEHDQQLLDHYCQLGVTSQIYALKILETAFSEVLTCTEWLVLWDHILSNEPAYILMIVVSYNIVQKNAIRRLKTVDQIEKFFHLQNPINMKVFLKKAYVFLNDTSEDVHPRRFFNSFVSLEKGGCYQQFTGYPKATICLKLARERKKAVSADRYTLRELTKKSQEKIINEGIKKLDIDFDKDNDKDVKDEYYKKHRRKSTVHLQNKDESRSRVREEFLKNVFFTSDLGLKISKETAESMRTRRFRESIRPKKKRKTPEKIHSLEKEVEKLIKSCSNSDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I940</accession>
    <name>A0A0N1I940_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Importin beta-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Karyopherin beta-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_05539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I940"/>
    <dbReference type="FunCoup" id="A0A0N1I940">
        <property type="interactions" value="2536"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I940"/>
    <dbReference type="InParanoid" id="A0A0N1I940"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="875" mass="98241" checksum="31557CF0FF05B101" modified="2015-12-09" version="1">MEWKPEPEGLRQILTLLKESQSPDTVTQRAVQQKLEELNKYPDFNNYLIFVLTKLVSEEEPTRSLSGLILKNNVKAHYNNFLPEVAEFIKRECLSAVGDPSPLIRATVGIIITTIASKGELTSWPELLPALCHMLDSQDYNVCEGAFGALQKICEDTAEVLDCDELNRPLNVLIPKFLQFFRHSSPKIRCHAIACVNYFIMGRTQALMLHIDSFIENLFHLAADEDPDVRKNVCHALVLLLEVRLDRLIPHLPNIIEYMLIRTQDPEEGVALEACEFWLSLAEQNVCREVLGPRLPALLPVLVRGMRYSEMDVILLRGDRDDDADDAEPDRESDIRPRFHKPRSHTIKHNAGAGDSNMSGGGESDEEDDGGAEGDDGSLSDWNLRKCSAAALDVLANVFGADLLPVLFPILKETLFHNSWIIKESGILALGAVADGCMGGMVPHLPDLVPYLVCCLSERKALVRAITCWTLSRYSHWIVSQSHDQYLRPVMTELLKRVLDNNKRVQEAACSAFATLEEEACTELVPYLGHILQTLVYAFGRYQHKNLLILYDAIGTLADSVGHHLNKPEYINLLMPPLITKWNVLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVFRRCVSLIEQTLNQNIANSQSPEQFEAPDKDFMIVALDLLSGLAEGLDGHIDHLVHNSNLMQLLYQCMGDPMPEVRQSSFALLGDLTKACFQHVHLYIPEFLNILGMNLNPELISVCNNATWAIGEISIKLGPETSKYIPLVLGHLVDIINRPNTPKTLLENTGKCTSLRNIRDNDEKDSAFRGICQMIQINPGGVVTDFLYFCDAIASWSHPKDDLKEMFTKILHGFKNQVGEENWRRFTDQLPVQLSARLSAMCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9I6</accession>
    <name>A0A0N1I9I6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9I6"/>
    <dbReference type="InParanoid" id="A0A0N1I9I6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="241" mass="27387" checksum="4741CEF75AD1383E" modified="2015-12-09" version="1">MEFENDFSLKEWAKDKPLSILQLDPADRAVLRIAVNIDEHIAISLFGKNTKETACFETKRTYRREGLNEIPIGPYATKEGNLLVTAASDNRASKEVKKTERREMECIHESDEEEEDKFEINPLVSHPMPKLTTQRSHTNMNHPSVRTIGMPRAKTCDKPLQEFEKNAALGLGLTTAASVGAMQRVNDALSSALDPLSRYAPVLLKLRYVQQLLRSYEPPRYLKITILSHKIYDQISAKYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9W3</accession>
    <name>A0A0N1I9W3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tudor and KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9W3"/>
    <dbReference type="FunCoup" id="A0A0N1I9W3">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I9W3"/>
    <dbReference type="InParanoid" id="A0A0N1I9W3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20412">
        <property type="entry name" value="Tudor_TDRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047380">
        <property type="entry name" value="TDRD2-like_tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="587" mass="65640" checksum="4701F7808520A44E" modified="2015-12-09" version="1">MPLNTKLLLPAALGLSIVTVTAFVAYYIFKKEEEETSEKTVKAPKLNTIEVSVPKSIVPALIGRNGSNIKDIESKSGAMIHFKKFSDKEYDVCIIRGRGQATQIAETIIQDFIKQQPVIETDTMLVPGWACGRIIGTGGENINNISHRSGARVKIEGSPSAESSTQRQISFRGTKEQIRVAKELIENCVAQEKCRREIEQSKRTPRVTIPPPSEPQPQESPGRPALRHAKCKPEDVLRKYFTSDPNKLENEEVVNGNNVFPADIDFIEEASSSSIEVYVSAVSSPSRFWVQFVGPQVAQLDNLVAHMTEYYSNKENRAAHALHTVSVGQVVAAVFRHDGRWYRARVHDIRPNEFDATHQVADVFFLDYGDSEYVATHELCELRADLLRLRFQAMECFLAGVKPAGGAERWNSQAIERFEELTQVARWKPLLSKTCTYKKSVAMVGDKEKEIPGIKLFDVTEVLGMLPSTRSSSLPKDHKDDRSEDQTPELVKDLTPISPSKSLSSGLETSDKLKSISNFDLSYSEFGKPSQNGSDEDFINKERSNMESDISSVPNTPSLKTRDEFKANMNRIDSHHNNLEALGRSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBS8</accession>
    <name>A0A0N1IBS8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dynamin GTPase</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="EMBL" id="KQ460012">
        <property type="protein sequence ID" value="KPJ18452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBS8"/>
    <dbReference type="STRING" id="76193.A0A0N1IBS8"/>
    <dbReference type="InParanoid" id="A0A0N1IBS8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045817">
        <property type="entry name" value="OPA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF67">
        <property type="entry name" value="DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19434">
        <property type="entry name" value="OPA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="280"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="47983" checksum="E1C03C13687CFD77" modified="2015-12-09" version="1">MYFAPNVLNSKHTCFQTTPTYRQRELDRDELFERARAELLDQSAEVSAVAAAAWERRLQDALWTAAKDRVFSGIYLPAAAQAHDDVDKFNTVVDIKLREWAERELPTQSVLAGREALREEFAALMSRAQDSDPVYEPVKREAVEEALRRHTWEERAQDVLRVLQLNALQDRCVASRADWDSAVTLMETALKEKLTAVDEELKSLTGPGFREKWLYWQSPSEEQQRRGEVRAELERLGSSRPSLAHDEVVAVRDNLRRRGVEVDNDYIRETWKPVYLNNVTDLVSSCDPQGKRTIFVLTKVDLAEENLANPNRIRRILEGKLFPMKALGYYAVVTGRSRKDDSIQSIREYEERFFRSSKLFKDGLVTPSQVTTRNLSLAVAECFWRMVRATVEQQADAFKAMRFNLETEWKNTFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID66</accession>
    <name>A0A0N1ID66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-type proton ATPase subunit S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_02993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460820">
        <property type="protein sequence ID" value="KPJ12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID66"/>
    <dbReference type="FunCoup" id="A0A0N1ID66">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1ID66"/>
    <dbReference type="InParanoid" id="A0A0N1ID66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF4">
        <property type="entry name" value="AGAP001624-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="352" mass="38361" checksum="8FABF0E2DAC1A931" modified="2015-12-09" version="1">MRIYGEQAAIVVFNNQDPVPLSSGYFPRLRKMLERQSVLVLPQDFLDVHPDYVSNETQVLTLQGPWSERDAQMTETFARLQDIYGPGRVLGVLGNSVSQSQAEYLGPEVTESGEWGEAGRVKREATDAPRSTQLAAAADDDKPAKVLPKYALYNATGPPGKAALLYSSGWPELQWADGSVTVLDTPIGEPTIKPTRLYTILVVRFADGDNTRDKITLEFSFKQSAGWWSAAGVEVTRGRGVGLGLLPPAPPAAPAAVLGHAYSCPQPLVYAADNATLTFPDIMMQPFMENTQKFGDAFDCIGFTSVPIWSGLMVSCIMVLGLAVSICMIMDIKTMDRFETSRSKQLTITVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE63</accession>
    <name>A0A0N1IE63_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01026996">
        <property type="protein sequence ID" value="KPJ21148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE63"/>
    <dbReference type="InParanoid" id="A0A0N1IE63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="616" mass="68336" checksum="E0583D437CE6C231" modified="2015-12-09" version="1">MSLTWPSPILVKLRNPNENPITTSLDNNQISWIVSVSFLASVFTTILMGFIVNRFGKKQWLVFAYLPRITSGFIYVFATSYWMIIIGRILNGISDVLILNSVASYSAEIASKEIRGSLGTIPQILSSLGMLISLSLGPYVSYFVLNVTFTSIVILTFIPILLLPESPHFLYSKGRYIEAFNVLKYFRDSETLALIEMNEYGKEKNIEIDREAILKNKLFIKGTILGIMLGLGTQLMGYNTVSYYLQTVLESTKTSVEPALASVIVGVLQLLGSLFSSSVIDRFGRKPILVFTSIGMAVGMMGLGVFFKVLEINANSIFGFINYLPLVSLGIVVLCFNSGIGSVYLLLFSELLDTSNVLKNAKVMLLQEVNEPTLNLAVSKAASLMGATDVSIKDKLVWEYDYLGRVFSMMCDIIFVSTSTHGCVGRFAEQSSVPVMCVRSRAHASLQALATIMTIIEEYGTMNCIDIAYIGKAHPVLNSYLLLCPMLGANLKFKCCCDKCPVSPLLYKASEDMTKKSQTVVKQCKHKDDVLHQSCVVIAGPATNKEDKIKEFKFGVEDIKRCNNVNKWIFFHTLPRGAEIDDQLFMHMNARTFNAVNNMQYIAAALMAKAVQGHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEB4</accession>
    <name>A0A0N1IEB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein bric-a-brac 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460954">
        <property type="protein sequence ID" value="KPJ10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEB4"/>
    <dbReference type="STRING" id="76193.A0A0N1IEB4"/>
    <dbReference type="KEGG" id="pmac:106715952"/>
    <dbReference type="InParanoid" id="A0A0N1IEB4"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF109">
        <property type="entry name" value="FI07618P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="38626" checksum="3BFCB82A2313C9E2" modified="2015-12-09" version="1">MANSQFVVSSKLHDKNICSALSCLQQNGEFVDMTLAADGHFVKVHQVIIAIASPYIKDLVASANCQHPVIFLNKISHSTLCAILEYIYTGEVIVSMENLKELVEAGKELHIKGLEDMTLAHATYVNSKNETEDEDKIGMNEIYLETSSIDNFATEDKVNMGMEIKDMNEDDDQEIFLEDMEQDDKIINEESQDDNDDYFTGDHSYHDKIGKPVLSSVGISKVKITNANKDTESSSLQYTVSNQGSLQMILNRYMYYLKYTNRNRSRQWRCVDYLKSVRCPAHVVTKDDVVVQRIAAHTHPFHDERILKKLRAGAIFSALVEAEKEGENILRSKSIEGNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGY8</accession>
    <name>A0A0N1IGY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atrophin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGY8"/>
    <dbReference type="STRING" id="76193.A0A0N1IGY8"/>
    <dbReference type="InParanoid" id="A0A0N1IGY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF11">
        <property type="entry name" value="GRUNGE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="794"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128386" checksum="971A4F8E13AEBF93" modified="2015-12-09" version="1">MDSPSTPRLENLQRISPSPTNARGAPSPAHIEHSTTTSNEPVSPAHSQEIKSHETEVEEKQPTDLKTQPIQPKQDIQNTGLRQPMFPTPVRPENLGIRSTEASNTPVSIQSMLPPPHSQPSITSLMPPGPLISVGSGSNVGPYGFIPSPLYGHPGHPGLDKPNSMPQIMQQVPQSHNLQGNLMPPSSNQNDSSMPQDLKIKQELPDMPANLSTQNMSDPLQSLKEVKVPGYPIGSAIAQHLSSERDRESISSVENNSRPPSQPTNENSNMSSAFLGPRIESIKKEPDFMHQPHITPVSANQVNVSESMNTIPPVKSPHTPTPIKSQPSHNSIGSHGPHPSATTSPFSRHLTSPSQPRQISASPVQPNIPVSHSALNLMNPSPLSIPSTIPGPVMHSGQQHGPHPSHPFASPLHHPHHPLLHPSSIFQLSAAAAAHAMHPYYTHPHPGYSMPYPYPYGPLPQTHPIPPMHPAPSTPGRHDQGKQSTIESTTMLSAHHSTSSSVTTRSLREISESTEDPRNPNATTERHQLHETTMTHHHSTSHHSAVHTSTEKQPNHVGGGTNHTLSISHSTSSSSSQSIQHKINTQQKTSSHSSSPHHLSASVSQTTSTSSSVNNHTHHHSHHLAHHPERLSPADSMLLRHHPKMLPGNPNHLMIQPPSMGHPMALGLPPGPGPSSIESLRLHAQAAAGLQASHARSGSPHQIPHGHPHLRGPQRPMPDENVELKLETQSQPEEEEIPSPAHIPHGPSPEPKIEDTECHRSQSAIFLRHWNRGDYNSCTRTDLIFKPVPESKLARKREERLRKQAERDREEREKIAQQSHRKIATPEKPETKPPSRGAIETITSPYDRFPRPPGYPDTPALRQLSEYARPHAGFSPGNLPRHCMDPMLQYQLSSMYGAAGARERLELEHLEREKRDREIRELRERELNDRLKEELLKNNVGPRGLDPHWLEMHRRYGMPPPPPQGAIPVQFGLYPPGHGPASLSHLERERLERLGIPPGGAGGPPTSVPVSGAPPHHPHHPHPGVAAAQLEAAERLALAADPMVRLQMAGINPEYHAHTHAHTHAHSHTHLHLHPGQQAAAQAQQDALSLGLGAGAPYRPLPHPDLLGRPYAEQLAQQAAAHEQLQRQLLMERERGFLHPAHHEDFLRQQRERELKVRALEEAARASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHE7</accession>
    <name>A0A0N1IHE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Venom serine protease 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHE7"/>
    <dbReference type="STRING" id="76193.A0A0N1IHE7"/>
    <dbReference type="InParanoid" id="A0A0N1IHE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF134">
        <property type="entry name" value="AGAP011908-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="180"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="43567" checksum="083BB0B941147C57" modified="2015-12-09" version="1">MMKEVTIEMTEDRYGARKLERRTYMILTTLCFLLAVINYGWAQNPNCDFTQNVQANRVYYVYSPGYPRNYTPGVQCRWIGICPAGYNCRLDCPEVNLPQSNMCSMDRLLISRTGDPQLSSSEYYCGRGTLSVTSVAQRLSIGFISSNYSPGGRFYCRLTAQRAAVTPTPCRCGYKKSNRIVGGQETGVNEFPMMAGVVYADIRQIKCGGVIISARHVLTAAHCVIRRTVNDIAVVVGEHDVNTGDSPATQGFRVVDIRIHPLYNLSNYDNDIAILTLQQDIVFSDRVGPVCLPFKFINNNFAGDKVTVLAGQLSPFNLLQRPYSELMMYKDVCSQDDSGGPLLYTDPSNGLLYGVGLVSYGTFCASGSPAVNTRVTLFLDWIVATTQADFCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHU7</accession>
    <name>A0A0N1IHU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHU7"/>
    <dbReference type="STRING" id="76193.A0A0N1IHU7"/>
    <dbReference type="InParanoid" id="A0A0N1IHU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="18557" checksum="25D1EE651C0E583A" modified="2015-12-09" version="1">MAGAALVGLVGAAGVFIYEQIYAEKRRAMLVREVARLDKQVSTMRSELEALRELQKETQLRRMKQKRSPRPKEVKSPKAAPLGDTVDAPEQSYASDSEYFTDYQSVIATDGEMDSEEFYDVPTDDEDDTLRESLRNGNAAKFTLDDDKSDKLDLPVQQNVKENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II30</accession>
    <name>A0A0N1II30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_00212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01037049">
        <property type="protein sequence ID" value="KPJ21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II30"/>
    <dbReference type="STRING" id="76193.A0A0N1II30"/>
    <dbReference type="InParanoid" id="A0A0N1II30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="14894" checksum="C5A0A050328A6D45" modified="2015-12-09" version="1" fragment="single">YICTQCDRRFGIKRDLERHMNRIHLNIRPYKCDLCEKAFNNSWCVKKHKKISHEGYKRPYIFPCTMCDKIFDQKSILKSHIRTHTGERPFQCTICPAKFTQSSSLGTHTKLVHLKQTRAGKPKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKY7</accession>
    <name>A0A0N1IKY7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040457">
        <property type="protein sequence ID" value="KPJ21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKY7"/>
    <dbReference type="STRING" id="76193.A0A0N1IKY7"/>
    <dbReference type="InParanoid" id="A0A0N1IKY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="16834" checksum="EAD4F6F227326184" modified="2015-12-09" version="1">MITSHESLNNLKVSLFYLILTLYIFLLITLLMLFILFSGSILAVVISDPHAQGKTNRFVGICIERKGCGLRAEFTLRNVVDHQGVEIRYDLYDPTIQSIQILRLEKRLDDKLFYLRDALPEYSTFSFDMDPEILPEGTPVPVNPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INL1</accession>
    <name>A0A0N1INL1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INL1"/>
    <dbReference type="FunCoup" id="A0A0N1INL1">
        <property type="interactions" value="2086"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INL1"/>
    <dbReference type="InParanoid" id="A0A0N1INL1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="8">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="419" mass="47480" checksum="1CE110064916CD39" modified="2015-12-09" version="1">MTSIIKLHCLSGAGDESPPCYVLQVDEFKFLLDCGWDEKFDMDFIKELKRHINSIDAVLLSHSDPLHLGALPYAVGQLGLNCPIYATLPVYKMGQMFMYDLYQSHRNVSDFDLFTLDDVDAAFDRITQLKYNQSVDMKGKGHGLRITPIPAGHSLGGTVWRIVAPGEEDIVYAPDFNHKKERHLNGCEIEKIMRPSLLLLGAANADYVQQRRRLRDEKLMKWMSDKLTRAFEGARSNPFALRHLQLCHSVVEVTRTPGPKVVLASFPDLEAGFARDLFLLWAPNNLNSIVLTARTSPGTLARDLIDKGGDRTIELMVKKRVRLEGAELEDFLQQQRMKINNTDKEDIGGISSDSESEGELEMCVVTGRHDIPVRHDTRPTGCFKTNKRHHAMYPFHEERTRADDYGEIIRVGRNCVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP55</accession>
    <name>A0A0N1IP55_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic FMR1-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CYFIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460736">
        <property type="protein sequence ID" value="KPJ12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP55"/>
    <dbReference type="FunCoup" id="A0A0N1IP55">
        <property type="interactions" value="1376"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP55"/>
    <dbReference type="InParanoid" id="A0A0N1IP55"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117921" checksum="7A083F95A8E567E2" modified="2015-12-09" version="1">MSVSEKVSLSDALSNVDVLDELTLPDEQPCIEAAPCSILYQANFDTNFEDRNGFVTGIAKYIEEATVHANLNELLEEGNAHAVMLYTWRCCSRAIPQPRSNEQPDRVHIYERTVQVLGPEVDKLLQFMYFQRKAIERFCGEVRRLCHAEKRRDFVSEAYLLTLGKFVNMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMADSQSLQESQNLSMFLATQNKIRDTVKDALEKINGYEDLLADVVNICVQMYETKMYLTPSEKHMLVKVMGFGLFLMDSEVCNINRLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHYDPSKWPLSSSPNPPSPQADLMVHLPQIREEHQNYISELARYSNEVTTTFKEAGSDAENKAVTELCLRGLQLLSSWCSVLTELCSWKLLHPTDHTINSRCPAEAEEYERATRYNYTSEEKFAMIEVIAMIKGLQVLMARMETVFADAARRSIYAELQDFVQLILREPLRKAIKNKKDLIRSIVVSVRETCGDWARGCEPQQDPALRGKKDADASFTIKVPRRNVGPSSTQLYMVRTQLEALISDKSGGRRTLRKDLDATTLTQIETFHRQSFYWGYLLNLSGKSIAPTYVLYPLDLYNDSAQYALTVFKKQFLYDEVEAEVNLCFDQFVYKLSEQVYAHYKQLASSMLLDKRYRAECAARGASTGGGAGRYASLLRQRHVALLGRHVDLNALVAQRINADMHRALDAAVAKFEAGDITGVVFAAGVQRERPQQYGHALLWGSKQLGFPYAAQYAQYAGFVGAQHLHALVRLLGYQGVAVVVGELLGVARGLLHGTLAQFTRALAAAMPRHCKLPRYDYGSNGVLGYYHAQLTDIVQYPDARTELFHAFRELGNIILFCMLIEQMWDSSELIPFIFDDIMVYLSHGVLGYYHAQLTDIVQYPDARTELFHAFRELGNIILFCMLIEQRRFEALDFCYHILRVQRVDGKDELVKGIPLKRMVDRIRRFQVLNSQIFGVLARHLVADEERAGVEHIRCFPPPTAPHHHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP84</accession>
    <name>A0A0N1IP84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP84"/>
    <dbReference type="InParanoid" id="A0A0N1IP84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874195" evidence="2">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="224" mass="24978" checksum="4F7D9483625C1254" modified="2015-12-09" version="1">MRLLHIIIVLLAALTLGHQCAARPSHRRNHVQKRSWCLLKLCSYQPTPHRVQKIIDELARRINVKTLDSYYAFNICRYLASVALSWSSSASALSAERRAAAAEAGRPRSNPRPPPDTAQHTTSNRAAAQRTSGLLCLQGCQNIKNKSLDAVLSVGKVLHKNTLVSVRVFEEGKKEKIFIATKKIQSKKKKKTHIQGTKSGKREPAQRSRNRLNCPCTGFQLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPG6</accession>
    <name>A0A0N1IPG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460389">
        <property type="protein sequence ID" value="KPJ15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPG6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPG6"/>
    <dbReference type="InParanoid" id="A0A0N1IPG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF57">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="2">
        <location>
            <begin position="424"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="872" mass="96227" checksum="4835730174FC5E54" modified="2015-12-09" version="1">MDLTTLVSRTFLTLNRITELSVMETRTGREVRSLRPQRRRCLYNDEPVGKDRQVGQLIHVPTQVNRVCISTSNPVLCQSLDKDGSRAVCQPVESRIDCALRLARNSVDVGVFSEEEMMLLSQMQPNDNRVVATIRDVNRQEPYAFEAVAIVPNSHTGGLEGLRGGNYCHPGFDEAEVRWSPRVLKTFERVVARTDRCPDANVAGKTAEELELETLSQFFPRACRPGPWSANTTVDTNLKGRFSSLCSLCGENSGCSGYTLDMGVNVAGVSNTNRHIQALECLRRSGNNSVAYVAWQHVREYFTSRNPQDAEQYSLLCEDGTLSPLTPDVLSALTSPCAFVRQPWSAIVATSSIASTVQASMRSWWPNGANPGGNNWQAILFSGIIGGTNARVIFDDTLPSPANYTSAVRNITSIDATTSCLPARRWCTISAQEHTKCTWVRSAAYTLGIEPTVSCQQRTNTFECLQDIKEERADFIATPANYGYISRQHYQLSALKLVQNTRSDPAAFSRVVALIKDSAQENITRFENLRNKKACFPEYGGIVTCAYDYTNMYYGNNGSLSCLADPETDVAFVEMQNINSQLSSLGLQGSQFRALCRNNTLAVTNGTLGIDQACLLAYVVDSELLARRSDPLLNSLSVLLDNLDQYFGYNAASGTQHINLEMYSAFDGINDLLFKNTAVGLSEPSTETANEPARNYIELFKHLDACTSVAPPSLAKAAHKECKSTSESESSSSSSSSTLVTYCAEKSDSDTEKEPDCDAEKSESDCAQEKSETDCAEKTKSETEWKIKIHIPPRVKCNTKTQTYIESNKADCDTEKTETMKKDCTKKEFTNANTQTEEIALDESAISCTIESETADDKLADFYNAVSQHWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPL5</accession>
    <name>A0A0N1IPL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AT-rich interactive domain-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460240">
        <property type="protein sequence ID" value="KPJ16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPL5"/>
    <dbReference type="STRING" id="76193.A0A0N1IPL5"/>
    <dbReference type="InParanoid" id="A0A0N1IPL5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="138" mass="15755" checksum="7519E8BB7407FBA8" modified="2015-12-09" version="1">MLHISEKKFNDMREANPHWASIDYVLVTPNLGLLNPVGDVSRMELVGAPCGQHGQYTFYKALRLSGKRERIVAIGDFFFVRIWQDSELVSIGELQLLWTDRVSDQTLVSLRLYFLPENTPEGRCQHGEVYTMLATVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPT6</accession>
    <name>A0A0N1IPT6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase HERC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460260">
        <property type="protein sequence ID" value="KPJ16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPT6"/>
    <dbReference type="STRING" id="76193.A0A0N1IPT6"/>
    <dbReference type="InParanoid" id="A0A0N1IPT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="18728" checksum="0D3C7772DCF2F3CF" modified="2015-12-09" version="1">MSPHQMSNPKVTMKTKIKTDKKPPHTISNRALSGVVNTLKSTEITSVGQEDTEEHSDESESALGLARVGARAALRLALSLVRRAWRCGEDADVCSALLRDALDAVRALPDAALYAGAGLGVTQAPRSQKIWAEVVDSAAKFLHQVVVGYCILTWFISLFLTFYVYIQKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQE2</accession>
    <name>A0A0N1IQE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQE2"/>
    <dbReference type="FunCoup" id="A0A0N1IQE2">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQE2"/>
    <dbReference type="KEGG" id="pmac:106709794"/>
    <dbReference type="InParanoid" id="A0A0N1IQE2"/>
    <dbReference type="OMA" id="GPNQYKF"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="9432" checksum="E9CF01E62E85D15A" modified="2015-12-09" version="1">MQGLSFQSLKKHKALIPLYVCTGVGAMGAVFYLLRLATRSPDVTWNRKTNPEPWQEYRNKQYKFYSPNIDYSKEESPAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PF52</accession>
    <name>A0A0N1PF52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat and FYVE domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PF52"/>
    <dbReference type="FunCoup" id="A0A0N1PF52">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PF52"/>
    <dbReference type="InParanoid" id="A0A0N1PF52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="422" mass="46554" checksum="52F8AA878785536E" modified="2015-12-09" version="1">MAAEIKPAPRTPNDRFSTTKKPALLSKLEGCTDDVNAAVVIPGEDGVISVCDDKTVRVWLKRDSGQYWPSICQYMPSGCTSMFYTPETRQLFIGQENGTISEFTLAMDCNRINPTREYLAHTARVTAVVFSLSCEWVLSVSRDKLFAYHCSETGRRIGGYSFEAWCTTLQFDSQSKYAFVGDYSGLITMLKLDNNGAALVTTLKGHTGSVRVLNWAPIPQLLFSGSFDQTIIVWDIGGQKGTAYELQGHSRESLASFHDMKHAVASLYVDEATGRLCTAGKDRVVKVWDAAALLAPAPRPGRILMKFSINVEHSLEEHIGLRQHHCRWCGAAVCGPCSPHRLPLPVMGFEFPQRVCTACYETLRHEPRESLASFHDMKHAVASLYVDEATGRLCTAGKDRVVKVWDAAALLAPAPRPGTSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PG63</accession>
    <name>A0A0N1PG63_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PG63"/>
    <dbReference type="InParanoid" id="A0A0N1PG63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="10343" checksum="F673C00BB093CDA9" modified="2015-12-09" version="1">MNDDGEANFIPTRKGSMLLVHNGYAFRLKNKLAYGKKQWYCTSRMKTGCHVDVTTVIHRHQNIVNRVRNTHNHPPPGFYRRTDGSFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH88</accession>
    <name>A0A0N1PH88_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460043">
        <property type="protein sequence ID" value="KPJ18347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH88"/>
    <dbReference type="STRING" id="76193.A0A0N1PH88"/>
    <dbReference type="InParanoid" id="A0A0N1PH88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="7420" checksum="B3560FB6F4FD1C4E" modified="2015-12-09" version="1">MDLTTIRRNIDSGQIRTTAEFQRDVLLMLSNALMYNSREHSVHTMALQMHEEGCYMFLITPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKB0</accession>
    <name>A0A0N1PKB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459892">
        <property type="protein sequence ID" value="KPJ19544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKB0"/>
    <dbReference type="InParanoid" id="A0A0N1PKB0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.500">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="357" mass="39656" checksum="8374CE7C6FDD4565" modified="2015-12-09" version="1">MASFAITDVYPSCNEETYRQRMFPHPMRAIHHQNNFPFPSFLYKKSVGRETGLKLSLRNAQSFDKTKNYLRVMPVCVVVLLHQTSRPFVQQKLLSSTSVKSSLNTAKVRQCFQPPEELPAVLPPLLLLTKELELLPELLLAFVEKTLEDAEDKIEKTAKKLASKASEDAQAAIKEVRAAIASAGKLTDEIEKSLKDLEEKVDKIKDVCLFEDISGTTQQILMKFVTDVEHSLEEHIVKMSKLSLLTGSVVLLVALAVFSTVEAGRPPPQKREPLDVKKKLEELSEKIAKILKDAKEKAEKTAKAIAAKASEEVKAAIKDAQDALAAAQKINAKVEEAFENLAKKIEKAINDIAKGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM86</accession>
    <name>A0A194QM86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM86"/>
    <dbReference type="InParanoid" id="A0A194QM86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7599" checksum="72B3403475D83BCC" modified="2016-10-05" version="1">MRESGDFLCAPFTFGIRKRLSAASKTLQKVHKEWGKNAWISAGNYVLPSDYNSTHNFDSVITVSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP71</accession>
    <name>A0A194QP71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ07149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Programmed cell death 5"/>
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        <property type="entry name" value="PDCD5-like"/>
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    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
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        <property type="entry name" value="PDCD5-like_sf"/>
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        <property type="entry name" value="dsDNA_bind"/>
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        <property type="entry name" value="TFAR19"/>
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    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="129" mass="14532" checksum="3105EF1C3D100717" modified="2016-10-05" version="1">MDDPELERIRQQRLAQLQAQHGGTGDPNHGKAQEEKMRAMEDAKHSILAQVLSQDARARLNTIKLSKPEKGTMVENMICRMAQMGQVGGKISENELIELLQSVNQQMPKTTSTVKFDRRRAALDSDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQA5</accession>
    <name>A0A194QQA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Focal adhesion kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_11244</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQA5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007172">
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Band_41_domain"/>
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        <property type="entry name" value="FADK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049385">
        <property type="entry name" value="FAK1-like_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041784">
        <property type="entry name" value="FAK1/PYK2_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF9">
        <property type="entry name" value="NON-SPECIFIC PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21477">
        <property type="entry name" value="FERM_C_FAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18038">
        <property type="entry name" value="FERM_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="FAT domain of focal adhesion kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="9"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="392"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="842"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1181"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1373"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1512" mass="165816" checksum="65F1A8818B61F135" modified="2016-10-05" version="1">MARAAGDQSTLKVHLPNGGFNVVRASPEEDVRSVLRLLAARLAAGDRLYAACYALRARRLTTGKIRWIHQDTAVSELAARWPASEWRLELRVRYLPANLRDLCDADRVTFHYYYDQVRHDYLNANHPMVDQDLAIQICCLEIKYFCKDMQISLDKKSNIEYLEKEFGLHKFLPKSVLDAIKPKVLKKAIQQQFKKVANLSDVECMLRYVETMHTHYGYDRETFTAALGGGWAIPVELAIGPDIDISYVSHKAGEPPTYTKIASFSDIVALQTLKSNCTQQSQTQSGSCGKGALQLRVKGATETLTIMCSSVEAAESLADLVDGYCRLVTDSQTSLWNRTTAEMSSSSSEGKTSSWEANTATILSEDYAEIVDDDADYSTPAVRDYELVRNQIELTGIIGEGQFGDVHKETCTLVLYIYQLSTALSYLESKKFVHRDIAARNVLVSTATCVKLADFGLSKRVDDKSYYKASRGKLPIKWMAPESINFRRFTSASDVWILETCTLVLYIYQLSTALSYLESKKFVHRDIAARNVLVSTATCVKLADFGLSKRVDDKSYYKASRGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMLGVKPFSGVKNNDVIGKLENGERLALPPRCPPRLYSLMSRCWAYEPSQRPAAHALKETLFEILQEERSTAWDTMRRENRRVAAASWGDDPPPKPSRPPANLPPVLDSSSTVGSGAGAGGAPQTYIVAQNPLVLAHLLRENQARAIEPQAYTTPASVFNTVAVDFAPALPETQLPRRAIPQPDELIDIPLHTAPIPAASLHRLDPLAPPAPTPAPPDTDPRDETLSGVVDARQSCDNLCQNTALEPRTDLSSPCRTETDVSTDTYPSRVRSLERNTRSSFSAERAPIRMGSLERNPRGSLSHRGSPVPVAPFTRQHSVPASPPPRTRRDQDVGQFSVQGCLNAQLAASVMNKMRQQPDPPLVEEIYDFGGDNVKSCAAIAAQKAMKPAYRAVATGMAASHPTSYGVPVGIVQGVQYGQGPSKGHQISKSTHFQSPLPQGCPAPPPGYGQPMGVVPPMYAPQQAYGSNVVQGAQPMLYRPQVSSSQNASQIASTSAYPGQVRPQFVSASSVDSHTVYATRQDCSPVVQASQPTPPIQPTQSPEFDTEQAVEKRLLAELARQQHQSEEDSKWLQMQEDNLKRLSNMQVAVESEPSEHKPSEPSGHEHRSSQPQSGANSSETSPANTVKTKPKPIEEKGVGEPVYAATTCVVRAVMRLAAAAGAGGAGGAGGAAPPALLACVRAVGHDLRALCATVDLIVVPYPPSAQREVEMAHQVLSKDMAALVEAMRLAVRYADTTLQHEYTKSMLAAAHVLAMDAKNLLDVVDCIRDRHPEVDWRAALQPPDTDPPHAPPTNTHPQQEDEPPPPKPDFKINQPVTTILTTEHSSKEHNSLPVTSNRVSTLIHNYNLYGNVREPQHIYGNTEVGGSFQHSTSCDDSKIDLAPLESVKSRVQAISGKIEPPVYSITKKMVPAENNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRC1</accession>
    <name>A0A194QRC1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled amino acid transporter 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRC1"/>
    <dbReference type="InParanoid" id="A0A194QRC1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF494">
        <property type="entry name" value="GH04538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="73"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="37496" checksum="DBB3F71CFC40EBD6" modified="2016-10-05" version="1">MKDPKIPPIRTVQDAYSSKIELAYNGSREDLDPYVPAEHRPTESNTSIELAYNGSREDLDPYVPAEHRPTESNTSSFGALAHLLKASLGSGVLAMPLAFKNAGLLVGVIGTLIIGFICGHVIHVLVKTSQQLCVEVKKPSLGYADTCDLVFQNGPKPVRKFAPFARELADWALAVTHLGACCVYTVVIAESFKQVSDVYGGPNWSVTVYCGLTLVVLIPLTQISTLKYLVPFSAFANFVWLGSICISIYYCLRDPPKISERNLATSVTGIPNFISTSLFAMEGIGVVMPVENEMSKPHHFLGCPGVLNIAMSAVAVLYGFVGFAGYLNFGEQVRGSLTLNLPQDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU29</accession>
    <name>A0A194QU29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU29"/>
    <dbReference type="InParanoid" id="A0A194QU29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="41" mass="4782" checksum="9574C46E23CDF958" modified="2016-10-05" version="1">MNDMLNNVDSAFHWFYRSGDVFILDRGFRDSARNASNKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU70</accession>
    <name>A0A194QU70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU70"/>
    <dbReference type="InParanoid" id="A0A194QU70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="37133" checksum="724DA1CEF585ED66" modified="2016-10-05" version="1">MAAICVSESVYREQDFVYLEGNKLPNGAMRTMIGMCGVMCASTHINQVNDAGVAGGPVQRHRNLECTQSARVGTADQAWPPYTVDLHATAPQRKDQRQCLLRHARPQHQHEDSPLIHLHKSQLSDCDCVVIILQLTVHKVPVIVLLMCLAWQASARAQDESEARAAPSRGLLKRGLLTKGKATTTTTTPAPQDDVEYEDDAEYAEEDAQEPSTEAPPSSTEGKKLVTGGVRPFRSNTDLLEALKRRRAQVAEAKINGQSSSSVDGVDAASKSSYNKKRFNTATRETNVEDAPPAPPAPSKPSRGRFGRPSSRSFQEAEPEEQNDAAPPARTGRTFSRGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN6</accession>
    <name>A0A194QUN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN6"/>
    <dbReference type="STRING" id="76193.A0A194QUN6"/>
    <dbReference type="InParanoid" id="A0A194QUN6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="502" mass="53556" checksum="3EA7714E56469A7D" modified="2016-10-05" version="1">MVVCQLTIVSTNSVVEFGPNASPEEVRRKNHRNTLLDFLDPRGILNSPGDAKLRSKRRDIAYFTPISSVKHTDALRLLFKTYLAFILATLRQGKPPLSPAFPKTIALVVLVLCAAAGGVAGSAVAWPGAAVALTAQLLNTVVQPQTKGFAYSTTQYINALPASYTYGVRPQFPYHVPVTAYAPLPGFPAYYPVGTASYIPQSSLIYPQIPPIATGQPQRPVSSAPTGPIAPIAPGIPQQPSIPQQPSVPQQPSVPQQPSNPPPEQAAGDADTTVVESAEFINQQQDQRTTSSDGQPQSSPANNIPDQQSQPQVPSYLQNPQISQFASFPQLPQGFPQFPQLPQFPQLPSLPQFPGAQEGISIPPFQQQPASTQDDLPSQKPPQQSAQPQPPSSLGDSLSPQFPQLPSFPQFPPSQGDLPQLPQLPSLPQFPPSQGGTPQLPQLPSLPQFPPSQGGSPQFPQLPNLPQFPPSQGGSFLPGFPSADNSNKGLNDEDTISVESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUT2</accession>
    <name>A0A194QUT2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer dense fiber protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUT2"/>
    <dbReference type="STRING" id="76193.A0A194QUT2"/>
    <dbReference type="KEGG" id="pmac:106717181"/>
    <dbReference type="InParanoid" id="A0A194QUT2"/>
    <dbReference type="OrthoDB" id="9948429at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026099">
        <property type="entry name" value="Odf2-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162:SF10">
        <property type="entry name" value="FI13205P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="315"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="457" mass="54123" checksum="238EC9B7E559A3D2" modified="2016-10-05" version="1">MPRSEYWPLAKVKPEDVQGCGESSLLQKQLGAMEGEVKEIQMELAAIKRDRLDLHNTKRQPIYEGSEHAIEDTVYINKVQENDFIKYTEMSKLREDLIRAKNAADEERFKRQKYESKLKDLELKLNNICTTALVTTKKEREPRKITDEEISCLKTQIRDAKDEIEEMRITLSEKTEQLQDYRLKYLQAQQQVEELKRQLDLYEFDNKQVSDQIQIEIQKMKMQFQEKLQELAPLPDLLKGSQMQLQEAKQMQRLAEDSTQQLSSELNRVKEKLVTAVNNFNQEKAEKYKILEENTAMRLSLDEKQKEICDLTRQVDELKCNVLRLEEKLLQEESMYDEKLAECAKLQKEIEELKEENNRSLTRSKERSESMRRYMQTQISELERQLVQSRAQTRASQKERDEIRQRMQVQINNLHESFELVEIRLRALQSQVTSLKNSYTVILSEDDEVSELNRITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUV5</accession>
    <name>A0A194QUV5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUV5"/>
    <dbReference type="STRING" id="76193.A0A194QUV5"/>
    <dbReference type="InParanoid" id="A0A194QUV5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="355" mass="41067" checksum="0578A20D37148280" modified="2016-10-05" version="1">MCDYLFSVDGVARLRPQTLRHLLSSGYDVIAPLLARPGQAWSNFWGAIGASGYYARSTDYMDIVSGSIRGIWNVPFITNCYLVKMALFHTPKGQEVSYVKEDVDPDMAFCNSLRDIGVMMYVSNEEDLGHLVNHETFDVSRTHPDVYQVLDNKLEWENRYLHKDYLANFIDGQKPRMPCPDVYWFPLMSPRFCKEWIDIMEAFGQWSDGSNNDKRLEGGYEAVPTRDIHMNQVGLERQWLHILKEYVRPLQEMVFTGYYHNPPVSIMNFVVRYRPDEQPSLRPHHDSSTYTINLALNTPNVDYTGGGCHFLRYNCSVRDTRLGWLLMHPGRLTHYHEGLPVTGGTRYIMISFVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWI9</accession>
    <name>A0A194QWI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Paxillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWI9"/>
    <dbReference type="STRING" id="76193.A0A194QWI9"/>
    <dbReference type="InParanoid" id="A0A194QWI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="10919" checksum="4F5D74DB25407469" modified="2016-10-05" version="1">MTINKRSHPLLFKAVNTPNEFSDQCPKILCLVPLECREPFHGGSFFEHEGQPYCETHYHGKRGSLCAGCHKPIMHHSHVQEVPSGTLCMCILSTTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXX7</accession>
    <name>A0A194QXX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ran-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXX7"/>
    <dbReference type="STRING" id="76193.A0A194QXX7"/>
    <dbReference type="InParanoid" id="A0A194QXX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="1">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="162" mass="18085" checksum="F10EA5B08851B254" modified="2016-10-05" version="1">MRCGERHADNRHSPLFRYEVAPRRFCSRPLASFTSHHSGAGGGAGGGCTRASVERMLAFGRELYAMSQRHTHDPCQRAMLEEAFSLLAYSNPWDSPVGWQLEPIRREPVCSALNAAILELHGRRWMSSVEACITHARELLRRMARASLGACAFADLPALLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0I4</accession>
    <name>A0A194R0I4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein retinal degeneration B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0I4"/>
    <dbReference type="FunCoup" id="A0A194R0I4">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0I4"/>
    <dbReference type="KEGG" id="pmac:106715052"/>
    <dbReference type="InParanoid" id="A0A194R0I4"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08889">
        <property type="entry name" value="SRPBCC_PITPNM1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000173">
        <property type="entry name" value="Membrane-associated phosphatidylinositol transfer protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000001">
        <property type="entry name" value="Phosphatidylinositol transfer protein membrane associated 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="7">
        <location>
            <begin position="656"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1169" mass="130999" checksum="E6D0B11D17CC14AA" modified="2016-10-05" version="1">MLIKEYRIPLPLTVEEYQIAQLYMIAKKSREESSGEGSGVQIIVNEPYEDGPGGKGQYTQKVYHVGSHLPGWFKSLLPKSALTVAEEAWNSYPYTKTRYTCPFVEKFSLEIETYYFADNGHQENVFKLSKSDLKNRIVDFIDIVRDQTSEYIKEEDPKCYVSQKCNRGPLSDTWLEDYWKEVQGKPQPLPNGKALMCAYKLCRVEFKYWGMQTKLEKFIDDVALRKTMVRAHRQAWVWQDEWHGLTMDDIREIERQTQLALQKKMAGETSDEQDVSEENSKSLAATMSSLEKKEDLDTPLTTKKSNIEKRVPIHLSPESTPPLEQKSSVRSNLRSSSSGSIKSLQAQVANWRMETLVRESETETGSEDEFYDCESSFNKWSSMCSLDEMEIDISPTQGDQSQDDSIFNPTFLKRVTSERGSRRIITLQNHQSMDGCPETPIPSSCPTTVLVLVFHAGSVLDATIDMAAKKSDVTTFKGAFESVMRQHYPTLVGHIAMKLVSCPSITTEALGILSTLSPYSFDCSPSTLETPSMTNDLIPIGAIPLLATSSPDYVDSVTKTIASANTVFNEFLKSDDGKGFNGQVSIVADSMGSLLAYDALCRTVQYQSRHDSENSVLNTEITIPNEPSDNYLNKSLLQAPTPRRRSSSTSDNQTKLEFEVNDFFTFGSPLPLILASRKIADDKTRDIMKPPVQQVYNLFHPTDPVAARLEPLLSARFTNLPPINVARYAKYPLGNGQPYHLMELIQSDPQLFGDHLQMPPTPILRRLSEASVQSTVSGLVDNIPLITMNALQQKWWGSKRLDYALYCPEGLSNFPTNALPHLFHASYWESSDVIAFILRQVGHFDLAFYGHVEDKDNTLFNPGQEREKWIRKRTSVKLKNVAANHRANDVIVKEGSPQTFTARFMYGPLDMITLTGEKVDIHMMKDPPAGEWTLLSTVVTDKTGRITYTLTEKQSVGCGIYPVKIVVRGDHTSCNFHLAVVPPQTECVVFSIDGSFTASVSVTGRDPKVRAGAVDVVRFWQDLGYLIIYITGRPDMQQRKVVSWLAEHNFPHGLVFFSEGISTDPLGHKAAHLNSLINDHGIILQAAYGSGKDISVYHNCGLSQKQVYAIGRISKKYTNMATTLSDGYASHLADLRQPGAVRAARGNARLLVPRRLLAPVSSATTRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1A5</accession>
    <name>A0A194R1A5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_13260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_7"/>
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    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
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        <property type="entry name" value="MDN1_AAA_lid_4"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="5154"/>
            <end position="5351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4444"/>
            <end position="5027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="4452"/>
            <end position="4466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="4467"/>
            <end position="4505"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="4520"/>
            <end position="4536"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4537"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="5363" mass="609611" checksum="3AC8B489D71025A6" modified="2016-10-05" version="1">[encoded data, 5363 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R306</accession>
    <name>A0A194R306_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_06442</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264879" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="42199" checksum="809A332AF709C19B" modified="2016-10-05" version="1">MFSLIILIVLSILSYLFTDELIPKLKELFIKAGIYGIDLCKNSKDKIPEAIGVVSGCVFLVTSFLFIPIVFGRSLMDREHFPHNEFAELLAALLSICCMLLLGFADDVLDLRWRYKLILPTVASLPLLVVYYVNFNSTTFVVPIPLRQFFGLSVNIGFLYYVYMGMLAVFCTNAINILAGVNGLEVGQSVIIAMSIIVFNIIELQGDQYKAHSFSLHIMIPYLATTMALLKHNWYPSKVFVGDTFCYVSGMTFAVVVPQLFHIIPCPRHRLPKYSGETDLLQASKTLIDKKDLNPISELILRVFSFLHLIDKVEDEVSITINNMTLINLFLIKLGPMSELRLTVSLLMFQTVCTCVAFLIRYPMASYFYDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3C9</accession>
    <name>A0A194R3C9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-tocopherol transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3C9"/>
    <dbReference type="InParanoid" id="A0A194R3C9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="91"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="35887" checksum="94952A785CA98F87" modified="2016-10-05" version="1">MTVRPLPDVLQEKAKKEINENHRSVESDISALKTWLQKQPHLHNINPSDQWLVAFLRGSKFSLERCKEKLDMYYTLRSVVPEFFSNRDPLDPKLQKILKLGSFLPLRECKETDGPRICILRIGVYDPSKYNLSDLLKVAFMITEIMMLEDDNFTVSGEEVIVDIKNVGVNVLSQWTPALAKKVITCFEKALPVRLKSNHILNTPTGFEAAYSLFKAFLGEKLKKRIRVHNQDYEALYKEIPKRLLPKEYGGEEGELQELTDYWVKKVESYRDWFVNEDKARSDESKRPGKPKTTSTLFGVEGSFRQLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3L5</accession>
    <name>A0A194R3L5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3L5"/>
    <dbReference type="FunCoup" id="A0A194R3L5">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3L5"/>
    <dbReference type="KEGG" id="pmac:106713770"/>
    <dbReference type="InParanoid" id="A0A194R3L5"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="27343" checksum="23051DBB447F3326" modified="2016-10-05" version="1">MARELQNKTIVITGGAMGIGYAIAENFLQKNPRVVIILDINENLGNEAINKLAVKYGKNKAVFYKCDVTIDLEIIFDKIIEEFTTVDVLVNNAGISNAHLRKTIDTNLIALMEWSLKFWEHMRKNESGKGGTIINVASIYGYRIDPYVPVYQASKFAVMGFTKSLGHVTNFTKYGVRVVAICPGFTSDTNLGSGSTTVLPELMENFKVDQQLWQKPEAVGKAAVEVFENADSGTAWLSEGGQPITLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4Y5</accession>
    <name>A0A194R4Y5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein bicaudal C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4Y5"/>
    <dbReference type="FunCoup" id="A0A194R4Y5">
        <property type="interactions" value="114"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A194R4Y5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22421">
        <property type="entry name" value="KH-I_BICC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054727">
        <property type="entry name" value="BICC1_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047549">
        <property type="entry name" value="BICC1_KH-I_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047554">
        <property type="entry name" value="BICC1_KH-I_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22985">
        <property type="entry name" value="KH_BICC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24234">
        <property type="entry name" value="KH_BICC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="703"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="804" mass="87756" checksum="869E32E30F9BB706" modified="2016-10-05" version="1">MATTNFLSVKTHLSDFKSNADKDAMSEVSESGTSNSVASAEDVQKLAVILGISNIEDVYQEKFRVDRRRLEGMLADNLEESQTAQAFFHRIMSETNTLINWPARLKIGARSKKDPHVRIAGRADDVKRAREKIMQVLDTRSNRVTMKIDVSYTDHSHIIGKGGLTIKRVMEDTGCHIHFPDSNRTSATEKSNQVSIAGDMERVERARARVRALTPLVFSFELPIAGAAQPLPDVTSPYVQQLQEQYNVQVMVRNRSKLHANMMVVKGVQWEVQATMEATGLLMNYMCGPLASQTQVHMSLEISPAHHGAVVGRGAEQLKLIMRGTGTQIMFPDAADPNIPALRKSCVTITGHMKDVYAARQQLVGSLPLVVIFDMPAEGGARLDEEAVGQLMQKHNVFISVRHKPKQGIASVIIKGIERCASSKFALPPWLVSPQHRAQLHLPPVQSVQSVQSVQHNNSPHLYKNSPNSWNSMCAGADMSGMQQQMLQPYHQMPDARPITLNQLLNCSSQASSGYQSNFTGSSVSLDVNNTSGGEASNVASPSVSPISAHSPAPSATSATSAPSNSADNDRNHNELASLISGMPLSARRAVGCEKKTLQTLARLSPLMDYQAKRAEAEKAMRESVGGGYRVPTGHWAGNYFSKTSPGLLTNNANGENNTTPEKGWNRSELVRPNIAEMMTPPKSAQPAAPREPSPQPAPAKQCRYQQLYDLLRDIGLYKYIDLFKKHELDMSTFASLNEADLVEIGVTAFGARRKMLLTIAELQKQAATFKGGATPGGGGGGGSGERALVHSPQYDLQPLQDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5S3</accession>
    <name>A0A194R5S3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5S3"/>
    <dbReference type="STRING" id="76193.A0A194R5S3"/>
    <dbReference type="InParanoid" id="A0A194R5S3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07401">
        <property type="entry name" value="MPP_TMEM62_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041871">
        <property type="entry name" value="MPP_TMEM62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="2">
        <location>
            <begin position="307"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="444" mass="50864" checksum="0983005818A64BF8" modified="2016-10-05" version="1">MASLLNIIATDHNFYIENKDEGLNYTKYLSEKYMKITDSSKNLIWFLQISDIHISIFRDPGRISQFQQFCDNTVKNIKPNIVLATGDLTDAKAKDNLGSSQVKKEWIYYYNIVQESGVTSKTIWLDIRGNHDNFNIKNINAQENYFRNYSVQGKTYPRSYVHILNENSVKVAFLGVDACPDPGIRRPFNFIGILDNQEQQHLQKLKLEAESKADHVVWFGHYPTSCILSLERDSQRLNLRQLISNAKGSQVYVCGHLHSMGGLVPQMYTIQRKGFLELELGDWKDNRMYRLAAIDHGIFSFVDQKHNTWPVVLVTNPKHALYAMPGREPLTLIRYSTHVRILAFSDVNIDSVQISYDKINWSQCKLAETPLYVCQWQPDLFKSGLHNLYVMGTDEIGRKTIVDHPFSLDGSNLQFKVVPRILLMLDAGGVVSVKIGGFTFVMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5V5</accession>
    <name>A0A194R5V5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5V5"/>
    <dbReference type="FunCoup" id="A0A194R5V5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5V5"/>
    <dbReference type="KEGG" id="pmac:106713263"/>
    <dbReference type="InParanoid" id="A0A194R5V5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000014">
        <property type="entry name" value="dynactin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="20067" checksum="60C5CFDE493D4713" modified="2016-10-05" version="1">MELQDTYYNKSEYVETASGNKVSRQTVLCGSQNIVLHGKVIVQSDAIIRGDLANVKTGRFCIISKGSVIRPPFKKFSKGVAFFPLQMGDHVFVGENTVVNAAVVGSYVYIGKNVVIGRRCVLKDCCMIEDNSVLPGETVVPSFARYSGSPARHITTLPEAMPDLMTEFTKSYYQHFVSITATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R631</accession>
    <name>A0A194R631_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">RR48_06776</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Ya'a_city_454_Pm</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R631"/>
    <dbReference type="STRING" id="76193.A0A194R631"/>
    <dbReference type="InParanoid" id="A0A194R631"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264954" description="Lysosome-associated membrane glycoprotein 5" evidence="23">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="236"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="25">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KPJ13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="533" mass="57386" checksum="44270D3724605F35" modified="2016-10-05" version="1">MGYLKVYIFLAVTCSSVIIGQGGITTKKPDLIDLPASVAPLKSISDAAPSVDVIGPSHEPQQSSSSQPDTTTASTTSTTRSITTTSTPAPITTTESAPNTTTVPTTTVTPAPEPKPTPAPGPLPRPTQGTWFYTDQSTNVTCILVQFAAQLNITYPKNNTSSLGYALLNVPANASVVDGNCNTTSQQLTLAWADGNHTLTMHFLANDTTKTYLLNSLNITISPEILVNSSSSLGYALLNVPANASVVDGNCNTTSQQLTLAWADGNHTLTMHFLANDTTKTYLLNSLNITISPEILVNSSLSRRVEVWHGAEWAMPLNTSYRCAADTQLNLTAEVTSVAATLTLSQLQEEAFRTQHNNNSFSSARECGSPDLPDAVPIAVGCALGGLVVVVLIAYLEGRRRSAARGYLSIGNKTRAFRPHGNLTPRHDTARHLPRQRLRVHCFMGAVKMPLLRDLLESVDKGLGCGTERTPRSRLVTVSDCIGTILNLNLQRALRSLISLNGYWQVIELLKFYFVVTLKSRHVSLLDQARSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6W1</accession>
    <name>A0A194R6W1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enhancer of mRNA-decapping protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_06757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6W1"/>
    <dbReference type="STRING" id="76193.A0A194R6W1"/>
    <dbReference type="InParanoid" id="A0A194R6W1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.100:FF:000001">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="8">
        <location>
            <begin position="182"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="34584" checksum="AAF5A66FF16C62F7" modified="2016-10-05" version="1">MRTSAANLEAGLGQPSSAPRANLVANEQPVSFTGLPLPLPNNESVKTFHKEIPRKEYKRIDSPDTNAEEDDLLVLTDSSIEGSSRSNEYLHTLEQKIEKLSDYLLEQEKILTDIKTELKLNNSFYNLSLAGISTELAEKGATEDFNISTINFLLTQCFDMVKLTKHDQTIIVICSKLKSAEIHNLMRAGEENSSFERALSAADLTLVVAACRAAEPARLFAPPCRLRQPVLLSLVQQLATDMVHDTQLKCRYLEDALINLNPYDAVTRTHLPVVVKEVREHLTKFLTDYPNHVASRRVALIIMAANNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7M3</accession>
    <name>A0A194R7M3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Filamin-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7M3"/>
    <dbReference type="STRING" id="76193.A0A194R7M3"/>
    <dbReference type="InParanoid" id="A0A194R7M3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21227">
        <property type="entry name" value="CH_jitterbug-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21229">
        <property type="entry name" value="CH_jitterbug-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000068">
        <property type="entry name" value="Putative Filamin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF13">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="163"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="463"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="553"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123783" checksum="526F3FF0F6DA18E8" modified="2016-10-05" version="1">MEGLRVTHQGVRAHSAEGSAGRITQAGLAARSPEGTAAKGMAIKGHEDLWVEIQANTFRNWVNETLKPVNIKVVDLVEDLRDGTILCALVEALQGRRLKGWSKNPNNQHHRLENVTTALQAIEDDGVKLVNIGNVDIVNGNLKLILGLIWSLIMRYQIGRSKFPPRKLMLSWLQAALPECRVSNLTTDWNSGVLLSALLDYCKPGVFPHWRELNRHEAIENCRRAMKLAYREFEVPMVLEPEYLASPWLDELSGMTYLSYFMKPDSPGFRATLDWVNSKLERGVTNFTTDWNDGRVANELVRTMGGPAPPPSRLRRDPAKWEENNQQAIDAAKKIGVQPVLSARDMSQNDMEHLGVMAWVSQFRNVPPRPPVHDMLRVALDSTSGRVGEPTYIKVESISNELSISDVRVSIVNPLEKESRLKLDSRGAGEFVPEHAGMHEIVLTVDDIRVDGKYFFRVLPRLVTVPPPGMAPCAAGSIVEVLVSATGAPRREDIDVTAHSPSGRAVPLQPRHPPPSAPGTTASSATFQPDEAGTWTIAITYKGKHIQGGPFTCEVFDPAGVRLSPGALEGAEPLKPHSFELDTSGCGVKGDLQLDIVHDKRSVMCALEKLSKTKYRATFMPKAPGKHRLYIYFNGYDVHGSPHIFRVGSRSKKPRDSASPSYARISSPVTRLRSESPLNQYNTYDTKRNTSSIDRREEGRDSEYYKTFSDVKEKSYDVIDSYTSTNRKDYTRYESESPRNRTASPITSKHLGNGTRLDVNRSSSPFRGGSPYRTTSPIGRTSSPLTRKDSPLNRTSSPINRVSSPTERYSPVTTTKRVIEKRSNYKIYSSYSGSQENLDQSPLSSLETEKVRGYNSPSAVEGSDPGGKSFISRKDSWDTVEKTRQMLSTNSLDPVSSSERHYTPSGQNTLDRETQRNTQLNRFSDYTHDTFNRQLNRLADDRETDYTTRQEYKREVRESSYVVRDSSYSAVEEKQQQEQFFLSNRPPRDPTGGALTETDAAHARFRLDQRENNKGAKGIIIKPTFKGIVGRPVEFIVDGGSAGPGELELEVSSGNGTLVASSVRALGGQRYVASFTPRILHPHSVRVTFNGEHVKDHDKIIQAYTDDVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8T4</accession>
    <name>A0A194R8T4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Fragile X mental retardation syndrome-related protein 1-like A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_06998</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8T4"/>
    <dbReference type="FunCoup" id="A0A194R8T4">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8T4"/>
    <dbReference type="InParanoid" id="A0A194R8T4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22425">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22427">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20402">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000103">
        <property type="entry name" value="Fmr1, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000004">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000054">
        <property type="entry name" value="Fragile X mental retardation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
        <property type="entry name" value="Tudor_FRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="435"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="517"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="584" mass="66158" checksum="0795614EC274359F" modified="2016-10-05" version="1">MEDLSVEVYGENGAYYKAIVTDVLDNEVLVAFENDWQPESKFPFSQVFLPPKDTGQHTEFVINQEVEVFARSNDKEANGWWTANIKMMRGEFLVIEYLEWDNCFSEIVAADRLRLKTPKTPIDKNTFHKFEIPVPDDLKEYANVENAHKEFQKAIGAALVWYVPERGTLAVISRCETSQKRATMLQEMHFSANVENAHKEFQKAIGAALVWYVPERGTLAVISRCETSQKRATMLQEMHFRNLTQKLLLLKKTEEAARQLESTKIHSQGGYSDEFSVREELMGLAIGTHGVNIQQARKVPGVTNIELEEVTCTFKICGESAEAVRRARSLLEYAEESIMVPRALVGKVIGKNGKVIQEIVDKSGVVRVKVEGDNEPQPSAPREEGMMSFVFVGTRENIANAKVLVEYHVAHLKEVEQLRAEKQEIDQQLRVVLNGPGASFPAPRGAPATRARRPRPPPQRYPPGGRRTTPELGEERGDSGGGYRGRARPPRPNRSSERRGEERRVPLENGRAHHPRPPRDQREPREPREPREPREPRDQRDTSGRRREGGREGGREERRRPTDEEAATTDVQDVSSADRGTPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAL2</accession>
    <name>A0A194RAL2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">Elongator complex protein 3</fullName>
            <ecNumber evidence="20">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">RR48_13610</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Ya'a_city_454_Pm</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="20 21">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the CIMIP2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="20"/>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAL2"/>
    <dbReference type="FunCoup" id="A0A194RAL2">
        <property type="interactions" value="1817"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAL2"/>
    <dbReference type="InParanoid" id="A0A194RAL2"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="17 20" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 21" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 20" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 20" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 20" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="23">
        <location>
            <begin position="83"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="22">
        <location>
            <begin position="397"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KPJ14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="610" mass="69189" checksum="838190B8FFDE5D9E" modified="2016-10-05" version="1">MTKKKPHPNLSKEEKMVIVISEIIQELLIAHRQGKDVNLNKMKTRISSKYGLGTSPRLVDIIAAVPADAKSILLPKLKAKPIRTASGIAVVAVMCKPHRCPHINFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMSLPEDYRDYFIRNLHDALSGHTSSSVSEAVKYSEKAKTKCIGITIETRPDYCLQRHMSDMLNYGCTRLEIGVQSVYEDIARDTNRGHTVKAVCENFNLAKDAGYKIVAHMMPDLPNVDFERDVEQFIEFFENPAFRADGLKIYPTLVIRGTGLYELWKTGRYRSYPPSTLVDLIAKILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMADLGTDCRDVRTREVGIQEIHNKVRPYEVELIRRDYVANGGWETFLSYEDPDQDILVGLLRLRKCAADTYRPELKPGPNANFKQCSIVRELHVYGSVVPVNARDPTKFQHQGFGMLLMEEAERIAREEHGSDKMAVISGVGTRNYYAKIGYHLEGPYMVKMLVPDPPLSINPTEIYHKHVGMLPNYAGHVPGCIFRFGKTYGNDTRDAKRWLRGDFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAT5</accession>
    <name>A0A194RAT5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAT5"/>
    <dbReference type="InParanoid" id="A0A194RAT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265042" evidence="2">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="11192" checksum="00C1FCDD7D95C1AE" modified="2016-10-05" version="1">MKTALIVLLALVAIAAAQVHVVDHNPSEVHVVDHDPSQVHFVDHNPSDGLNNPDGFVVDQGFYRPSNPPNGGYEQISNGPAYVDFGNRPSAGKHYDNPNLRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB80</accession>
    <name>A0A194RB80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB80"/>
    <dbReference type="InParanoid" id="A0A194RB80"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF28">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="400" mass="45231" checksum="2B13AC927B3AC367" modified="2016-10-05" version="1">MAENCRLGSQIDRKTATNDDEYFCVFNVLSVFISLVTILADLTTVLHWAAMTFWIVIQKTTFCPNKLEETLYNAVMGFVYCFSFINLREGQTRYRLMMFYTFMVTQNFGSLFLYVLITDTEKQKKPWSIAATICIIAGTIFGMFAMVLYYRYFHSKGPITWKYAEPDIELNNKASQTGNIPSKPSSLCHVRSFKSTNKDKTTDTPSKDPTITEQVSQIESEHADKKFLLDHWIARSGSPTFTSAPVGNVSTDASSIEIYSIENTPQSTATKRDNSKIEQITSKINKKKIIAPPTELTLKVPSVENIENSIDEITSIFFTLNLQKRRGICSSDELRNELTNLNLEACNIVNEEFAKTIKTDHSSEISHDTDGSNKKTSSDSIDMDLDLSFSDINSSDIKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCF3</accession>
    <name>A0A194RCF3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCF3"/>
    <dbReference type="STRING" id="76193.A0A194RCF3"/>
    <dbReference type="InParanoid" id="A0A194RCF3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="162"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="584"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="678" mass="76341" checksum="EF4DED96D8130E45" modified="2016-10-05" version="1">MYSTRYVPGQQSTSRKSRLEGKPSLLPKPRRTGSTEPEIRRPSGAGHRSSSAEPPRATLGGRLSREPSATNLPPISSRSKSQQSEMRYGASHYMSTPLHSNHNARSTNTPLEFRLPTSELKHGVTPLRYSHNLTTTPRRTVGDESSGRSWEQALDRVLAFVTVKDQRPLSNAGWQRAAAARVGEALALRASEGGKALALLRPLTIARFVDIVADLLGSLYNNPTLNTDNYVTKLPHITKRLLYPGTVSKSWLRTVNTLHAFPHALALIAYLLDLIHFCESPIEEGLIYLAKDDFADLKQDFIFRSWQRFQMPEYQFDDLSEEYLQNLKTLLGNDDEKIQELENKVKKQESELEDEAEAAARADVCRREERLSALLSAVRAERAASLHDTNITDDARAARQRLLGALGDIDAEVERAHVESQRLCEEVSAQSMSVSERAQLLEQVDYAFRVHDSKTALAEHISKCGEPALCEEVSAQSMSVSERAQLLEQVDYAFRVHDSKTALAEHISKMLLSKETELAGWQKRTLDSCVQYKQALIHLAPHCPDLASYNIDEKTVVDVGNNNICCTNAQPVKYHDHTEDRRQVEREKTEAARSAAELAAVREQIAGLQAAQAQHKHLDTELEFWQQQDVEWRSKLSSLQEYVVNKRTEVQQTLAEATNRRVQLLLHNIRLLNEKLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCS5</accession>
    <name>A0A194RCS5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone deacetylase complex subunit SAP30 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_09301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCS5"/>
    <dbReference type="FunCoup" id="A0A194RCS5">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCS5"/>
    <dbReference type="InParanoid" id="A0A194RCS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1800.30:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF6">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 zinc-finger" evidence="12">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="13">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ15274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="20118" checksum="854CE0BD26741561" modified="2016-10-05" version="1">MNNGFSTGEEDSRGNSDQICCLVDDGDRCRRPAGNASYSKRVQKTVAQRRLKLNIDHQARHTYICDYHKNMIQCARTKQRRPKDSEDDSNEADMDCPEIDWYQLQVNTLRRYKRHYKVPTRPGLNKAQLADAIQKHFKSLPVNEKEIMTYFIYMVKTNGNKLDQKNGINSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCY2</accession>
    <name>A0A194RCY2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCY2"/>
    <dbReference type="STRING" id="76193.A0A194RCY2"/>
    <dbReference type="InParanoid" id="A0A194RCY2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF47">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="899" mass="100128" checksum="90941670B1CED500" modified="2016-10-05" version="1">MIQVDNFKRSSPSPSRCSVRSDSRVFRQPRVIQVNRDAATMMDDEANAVEGPSSSEDTGLTPKWDSRLGHHGTQFRSRTFSDGFIRNTSLELLLGVECEACLALAAQRQCFNKQMSEHEFDLVCNCNVQQNNYLNCRRDVVKQRGHTLNIYDLERIKRDTGRSHLASGSHRSLDRKHSKARTIGVSNYISKQLIAYDQTNTLMQKLKRKLSNLKKIGGEAITKKHQNAVQLAEITSASSSSLKKLSMLSLVEKSQRKSNSQSGTFSSSSMQSKDDQKNFTTYANFSSNVDQCFDRLRDYNDSAETSSSGHKVLKLKKFDLNNDIVSRQSPVREVKKFSTLDNRSRCRSIRRQMSYNDFASERFRDRVTADSWSRDDNVFDSRSASNDVIINDDGQSFVSIDRGCRNVPRPVQAQCTCNSGRDNRIPSIFYDTHGKKRTIPAPDVTERGQNGRGTACVACKAGQWLPTGTTSTTSHSSTTTANSSRFSVWHRRWCCVAILVLVAGTACVAGPLALRTAPGAPLHERLRLAERLLHDTPLIDGHNDLPWNIRKFLHNRIKDFRFDEDLRTIAPWATSSWSHTDLPRLKQGRIAAQFWAAYVPCDAQHRDAVQLTFEQIDLIQRLTDKYHPQLTLCTSADDIMTAHANHRLCSLVGVEGGHAIGGSLGVLRTLYQVGVRYLTLTSTCDTPWAECASADRADPTQRGGLTPFGKVIVKEMNRLGMLVDLSHVSERTMRDALAVSRAPVLFSHSSARALCNVTRNVPDSVLRMLANNKGLIMVNFYTSFLTCSESATVQDAIAHINHIRSIAGVDSVGLGAGYDGINYTPQGLEDVSSYPMLFAELMEDGWSIEELRKLAGLNLLRVLAAAERVARDLAADHVAPYEDTAPRAADPHNCSSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDA4</accession>
    <name>A0A194RDA4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDA4"/>
    <dbReference type="FunCoup" id="A0A194RDA4">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDA4"/>
    <dbReference type="InParanoid" id="A0A194RDA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="167"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="743" mass="83327" checksum="EFA4925F8946179B" modified="2016-10-05" version="1">MVSGKFGFAAKKDKVIVTEAKTELSVKEKCRKIQKKLKKTDKQKTDVKEKAIWWNQCSSLSEIDQYLWMVGGSAGALALTGVAAASAFYLSTRPKPEKPLVTLHEQSLLESGPEMVRVSKFYKDAKNGRFLRYLHDDTRTLFETFRRGVKESNNGNCLGWREGPNKPYVWQTYNETLLRAKNFGSGLICQGLSPGQSTFVGIYAQNCPEWIMTEQAAYCYSMVIVPLYDTLGANACAFIINQTEMSIVVCEDDKKANLLLDQSPRCLRKLVTIKEVSPSTHQRARSRGVDIVKFSDVEIQGAQKDHPFVPPKPDSLCTICYTSGTTGMPKGVMLTHENLVASMCSVIMQLGEHRPSKHDVMISFLPLAHMLERCCENALYMVGGAVGFYSGDIRRLGDDLGALKPTMMPAVPRLLNRLYDKAQNEISNSKIKKLLFNMALSAKESELKRGIIRSDSIWDKLVFRKVREGMGGRLRIMVVGSAPLAGNVLTFARCALGCLIVEGYGQTECTAPVTLTVQGDHVPEHVGPPVACCKVKLVDVPEMEYYAAQGQGEVCVQGANVFKGYFKEPEKTRQVIDRDGWHHTGDIGKWLPNGTLKIIDRRKHIFKLSQGEYIVPEKIENIYIRSQYVEQVFVHGESLKSCIVAVVVPDVDVVKCWALENGIQGTFSALCENERVKQMILDDMLQWGRNAGLKTFEQVKDIYLHPDPFSVQNGLLTPTMKAKRPEIRNYFKPQIEDMYKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDB4</accession>
    <name>A0A194RDB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDB4"/>
    <dbReference type="InParanoid" id="A0A194RDB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9399" checksum="7C0D4EB6686B2E92" modified="2016-10-05" version="1">MNEKTLTPEPQAVAGPSGEANKRRRSSSSNSSNSSSTSSSSSDNKRRWSCRHKHKKSKRGKHSKQLMDKLFKEMGSHSWSTFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE76</accession>
    <name>A0A194RE76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-lysine N-methyltransferase MLL5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RE76"/>
    <dbReference type="InParanoid" id="A0A194RE76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000150">
        <property type="entry name" value="Inactive histone-lysine N-methyltransferase 2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="747"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="945"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1621"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2167"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2282"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="1479"/>
            <end position="1490"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1880"/>
            <end position="1892"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2206"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2225"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2248"/>
            <end position="2257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2467" mass="269140" checksum="4CDD3C73D8E0FC62" modified="2016-10-05" version="1">MSATSEYESTARQDYGPTTSSENMYEHVLEHKLTDNMNVSSIRTPVLRPVPLSPLEGDPEPDSTNPESIIQSIHKVDKEVDFRINDKHCDTEMSVDSLSRIVRIEETTLDNVGRIAYPILQETEDSGDANYVENATTLIQAPLNTAIMQNVTKLPQNFTINVDAAVGNITAIQNVAQDASGSQTLWLPTILTTSAPPDIKNDDERPPGVSQIIITSESYVNDTNQAGRRTNIIETNYIGRPKASKVQILSNISLPKSPTFAQQFISQDKEFTTPVYGTQNHVYKLSANVVTQKHLNSSVLNIKSPKSQSLIGCSSLSPTIINNSPIKNVSYSHTYTKSTNLNKAINKVNNGANLNTMVAASTGNTQCHILSRVVSGPNKMSVHSGRKSVNTIKSSKSTNQGSGQKESRAIKIIQQAGSSHKTEGKSWPLASVTYKNQQSIGVLETSPSKIIQKVGSPAPKSQSLSFQKVSKSDRLVLQSPCGPVLLSTAPLNINLPKGPHYVQSGSTPNLRYVQTYAPSDNQLSTVTQVSANQQLTEQILQSLSQPKLVLHQSPTVNHTIIPPPIIEEPAEIKPLNQKRIVFGDKSTLTTADDIVGMEERPNLSEELRRYSYQALAFIMLDHTYSLPAQKQPAVSTPPPPVTTSAPAVVSPAPITTPMSPLKRNSPVIMSTAAFDVPPATVPASVAVIQPPVTSVQTGVLAFKSTPSVTTQDDDAASVISSIDGDRAQGPRGGSDTETAPEGEEEGQTRCICDFTHDDGYMICCDRCGEWQHVDCMGIDRQNIPDAYMCEVCQPRPIDRRHARAIQLRKREELSALAGSDSDSSETPHLAGQRRKRLLTVTTYTNTSGSCVTTYNSNVPVLPPLPQPTLALPKRGPKRPKKAEMVRKGAKRKLAEKRVKRKKDMFNRTKYNSGLANQSHWQDSYEAAMTNHYSPELRAKIMKYSSKLGSSQSMASAITAHLCTTVPHAGGKILIATKDLKENTPVIELRGKYMLSNQHRPQLQNTARAGSQKPGPFVFFYRLPKDNTQICIDTRTYGNEARFVRRSCKPNAELQHCIIKGALHVYLVTIGVVQSNTEITVGHDTNGSKQPCACGNPKHCKVNGLNPIVTRKSIDYPQREKRSRNRCYSSSSPVSPPLLQMPTTPVKESPPPFMQIKNENRSPIKHEFSPMSPIKTTLNLSFDEPIKTEPFEDIKSEIDLMAKEEMKPELDEPDYVDSDLKHEQIQPEDLIPDIKPVVEEAPLPPSPILPPPILPPSVLPPPILPPPPVQPTPVLQPQVLPPPVLLPPVLPAPTPLPSVLPPPVLLTPPQQAPPLSPPPAPPVAIKEEPMEIIKEEASIKIDKILPKEVKEEIMEVKKPKEVPKVEDEKPVIKEERKEVVAKSACHDRSARSSRTTCTNQDSLDDKTDDSQDKLPVSTSQKDKKKMTREERKMEAIMKAFERMEKAEQRKQEVKERQKRRESDPHPNSMDRDEEEELHVNTKKRKRRKGRARTTSQSNRRRLNSADSDMVTSGDEAQPLSPPPRAAPAVDLPHPTTEERPHEVINEDIGLSSACLLVEAAVGSVESAFKLPKTKKTMATEWIGRSPERTPSPYHSPYRPALVSAPSLESLVRVASTMIGDLSGQDMEHEEEPSAISPPRTPGRERNRPPKKAKRITRSTPTEPVEVVPAALPQHSAKKRWLRQAISEESDSPVIEPFVEESPPNEMVTPLKKRRVARESLGCETNPIIHCMEETSPYMASEDSPVKDDPQSITRTQYKRNIMECMYSRDRTRSDSGQGSDDQCNMDHDVLNVNIKVPHDTENIRRIIGVPTPEEEITPQFTKPEDINTNNNNLEMEESNYNKVVPMEIDTTIITQAKIQESNDNSISELKGIESPNDKVHSSQSADTSGNSSPQRDEMDDIQKKIHSFHTENILILKSRNKKPPKEKRKKVNLNFDLNMVDDQISIQLRTENDTNSKSCEVNGDLHDDHSNSIHDDVKIHVSPENIPLPPVETIPLPASDNILVPAPENIPLPEEPSPMPLVAPPETIPLPEEPMALATGAVNVSNAKLSPVVSKPEEKEVVLPERPSVLDSTVPFSTRFSSTGLFSGIFSNLSNSFKLDSPINENIPNMSIIKSAIDRTTSLDNSLFDKDPIAPVDELKSVQEILTRVNNMDSNNSVLLSGVLKSSNKSAAASPSPSPSPKPGKPYGAGARNDPRLNPPPADKPKPVRRKLSITEYRKRHKCTASGGGGGGSPAGGEGAEGGEGGGEWSSESSGGASLSPQRLDAAAAAAVDDLEQRLHRDLSTAHTPKGVFDAQPTASERQRENLSSRLRREFGLALPDDDDARDTHAHVAHVAHPAVPAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAPLGAHAAHGKNTQTYRFNTNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REL8</accession>
    <name>A0A194REL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium-dependent neutral amino acid transporter B(0)AT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REL8"/>
    <dbReference type="InParanoid" id="A0A194REL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="142" mass="15913" checksum="C4120148669E3A0F" modified="2016-10-05" version="1">MTGRRPGIYWLICWKYLSPLAMLCILISSFAELAVGGAGYDAWIASEGDTERKSWPVWAVLLVVVLVLASVLWIPGLAICRYFGIPIIDDEERAWFPADDLRDFHGIEPRPVSNLETLLFCTRPDGTEGCCWPGCCETDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF01</accession>
    <name>A0A194RF01_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeotic protein Sex combs reduced</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RF01"/>
    <dbReference type="InParanoid" id="A0A194RF01"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="16306" checksum="6EBAFD8C60E5380B" modified="2016-10-05" version="1">MEAEERSGRCPNDRPTSQLISELSKHLSAAAMRLLCTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMNPYGHPYQFDLHPSQFAHLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF70</accession>
    <name>A0A194RF70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor DM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF70"/>
    <dbReference type="STRING" id="76193.A0A194RF70"/>
    <dbReference type="InParanoid" id="A0A194RF70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="101"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="33802" checksum="B403D2C286FDF99B" modified="2016-10-05" version="1">MAHATVPKYRELKQPNRGKNPVSYEQARIWPTQGVRLWVGVRAGAERGPGARRVDVMLNDSSVPANLTELAAALPASPYSLAQTIVIAIVGSVLSVLTVVGNSMVMISIKIDKQLQTISNYFLFSLAVADFAVGLISMPLFTMFTIFGYWPLGPHICDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTRRAKVMIGGAWGFSLVLWPPWIYAWPYIDGERKVPPHECYIQFIETNQFITFGTAIAAFYVPVTVMCILYYKIWRETKKRQKDLPNLQGGKKHDSSKRSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF89</accession>
    <name>A0A194RF89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caseinolytic peptidase B protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF89"/>
    <dbReference type="STRING" id="76193.A0A194RF89"/>
    <dbReference type="KEGG" id="pmac:106709556"/>
    <dbReference type="InParanoid" id="A0A194RF89"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF93">
        <property type="entry name" value="MITOCHONDRIAL DISAGGREGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="287"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="507"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="614" mass="68337" checksum="B7B731E27361F5CC" modified="2016-10-05" version="1">MFSHPRSFNRLLRLMTRSTRILSVPMRRSVSSNAAEKIYLTTHNSQLRKIVGAASLGLAILAADYVFNEKRFFKAAQTGNVQELVKQLEAASESRRGSGESAADLRHPLGWTALMVAAANDRPTAVRELLRRGARPDLRERYAGASAAASLAGLHPLEALQRREDEFCGSMNARASFLGWTALHYAALADSAACARELLENGADPTARDHAGRRPLHYTRDPSPARELILQHTRRWEEAAAAAAAEERRRFPLEQRLKQFIVGQQAAIETVAAAVRRKENGWADEEHPLVFLFLGSSGIGKTELAKQLARYMHKDDPAAFIRLDMSEYQEKHEVAKLIGAPPGYVGHEEGGQLTRALARRADAVVLFDEVDKAHPDVLTVLLQLFDEGRLTDGKGKLIECKNAIFVMTSNLASDEIAQYGLQLRREAEMRAAQRTRPQLADVPKEKVENKPPLPPEGGDAEDAENAEETLEVSRHFKDGVVRPILKKHFGRDEFLGRINEIVYFLPFSRQELLTLVNMELKLWAEKARSRHDVELRWEGGVLGALADGYDVHYGARSIKHEVERRVVNQLALAAERGALARGAGVLLSARAGRVQLAVRRARDQRYEPLDLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFF4</accession>
    <name>A0A194RFF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFF4"/>
    <dbReference type="InParanoid" id="A0A194RFF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="322" mass="36621" checksum="B485767C9AFAA51B" modified="2016-10-05" version="1">MHNLKNDEFRSPSIVKDDCVANFEPSTIKKLLGESFTRQLDSVTTFKAKKFNKTHDSVDPFDDLDSPQKAVETMEKSFNDMNLSKTNECDLKSKLALEESNIKKPLTEEIFIVAKASDSVVIEKETKVDNTLEAFENIYKDISQPRATDFDLLVAQEESSCNKEEVTSNTREVTQEATKAKYNLRKKLTDDSDKTNEIVTRAKRNLRLRRHKKQMEEAAEQEEGDKLKDIINLQLQFSDVTLGKPAPEPPARPASPEPKGEENLPPLSIQSCPSKSVTRSRRKLFTPRAEPLEDESGLCGDSGERLRVPRPSYHRPRARRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG58</accession>
    <name>A0A194RG58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Netrin receptor unc-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG58"/>
    <dbReference type="STRING" id="76193.A0A194RG58"/>
    <dbReference type="InParanoid" id="A0A194RG58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265156" evidence="8">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Netrin receptor UNC5A-D-like N-terminal" evidence="9">
        <location>
            <begin position="110"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="30132" checksum="F1BA8D9DA2F7CDE3" modified="2016-10-05" version="1">MARAGTVCLVLWLLAVVTDGKQEVSNSTEAEHITAAPTPPIPLRPEYAHPAGAEALDPYNSENNHPAPNHRDYLEEDYDHESHKEDDHDSRDDADELPSLSGDHLLQSSTDDLPIFLLEPQHAFVVRNKPAMLRCRAANALQVYFKCNDVRSVASTQFEFVDPQSGVRIVEAECNVTRDQVEEYFSEEFSCTCFAWSSRGDIRSQPAIVKLACNPINFESIIDHLNMAIFDLFSYETSIIVCKFEGVTTKDELLQYATRQNRLLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGF5</accession>
    <name>A0A194RGF5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COP9 signalosome complex subunit 7a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGF5"/>
    <dbReference type="FunCoup" id="A0A194RGF5">
        <property type="interactions" value="1670"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGF5"/>
    <dbReference type="KEGG" id="pmac:106709200"/>
    <dbReference type="InParanoid" id="A0A194RGF5"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="30459" checksum="1CC50951B37B6173" modified="2016-10-05" version="1">MNPMSVDRDEPSSLSSFSTNHPLEQFVLLAKGAKGFACAELIKQVLEAPGVHVFGELLEMPNIKELETGPYATHYKTLNLFAYGTYKEYLENKSEYLELTPVQCKKLQHLTIATLATQEKCIPYSVLLKELDIKNVRDLEDLIIEAIYADIIHGKLDQECKRVEVDVALGRDARLEDASGIADVLADWCNACEAVLSSVDRHIQRANHHKQKALRHQQGIEQEISYIKKTLKTQAENDESGAGGGSETHSAPKKASGKSKTPRNASKFWHKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGS7</accession>
    <name>A0A194RGS7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGS7"/>
    <dbReference type="InParanoid" id="A0A194RGS7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="157" mass="17643" checksum="35B885550E45653F" modified="2016-10-05" version="1">MPGTVVILNVGRVRKNEKSYVMCAVWYTVTYHLLAEHSLILMLLPSTSINRQTSTAFYEALNIKDTLISVKNSVYPSRTSRYLFCGVVARSFGNKEARLAQHNCGNRLPRRPVADWRSNARCTLGASIVYVHTLQPGRDTLCASTRQPQAQQSRPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGW6</accession>
    <name>A0A194RGW6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGW6"/>
    <dbReference type="KEGG" id="pmac:106708770"/>
    <dbReference type="InParanoid" id="A0A194RGW6"/>
    <dbReference type="OrthoDB" id="7395552at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265186" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="17324" checksum="8ADF5EC35B6F971B" modified="2016-10-05" version="1">MRSLVVFVAALTLAAAAPSGEPGLKKRSIGHAVAYTVPTSVLATEVVEPVVYSSPSVYAPAATVYSTGSAVSHQSRVDVRTSPTVVATSPAVVAASPAVVEARSVYSAPLYAAPAAVSHQSRYDVRSSPALLTEQVVAPAVYNQQLVAAPAVVDARSLWTPSVYTTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH34</accession>
    <name>A0A194RH34_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sodium/hydrogen exchanger 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH34"/>
    <dbReference type="STRING" id="76193.A0A194RH34"/>
    <dbReference type="InParanoid" id="A0A194RH34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="23264" checksum="F5DE152D8C18162C" modified="2016-10-05" version="1">MSFALAIRNTVSEARQAMLTTTSLIVIATVVLQGGAATHALAYLRIPTGQGQNDENEALPYRDVRSPADLGFGLRNLDASQPTSCDRAINGSMVVKWGKGDSGVIMPWQLNKLAETPRSEGGEKARLARLWGAVDSKLLKPLLTHARPPLTDTLPAFFRPIARVLTTTRQYTQGENNLHRTDSDSDLCIDEPQPVPASIDPQLSYNVRNGFGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHM6</accession>
    <name>A0A194RHM6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHM6"/>
    <dbReference type="FunCoup" id="A0A194RHM6">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHM6"/>
    <dbReference type="KEGG" id="pmac:106708713"/>
    <dbReference type="InParanoid" id="A0A194RHM6"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="134"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="49025" checksum="1D4368D0FC3FD421" modified="2016-10-05" version="1">MGTEIAISFTSLRNQLENEKSSLFKIDENIKKIVQTSGRFPNDRFNQSSHYTRGGQQTGGRNSYVDFKNHKIDDQLGKRKTETKTVFSRLSVRDQDSDGDDDFPSVKRAKVPSAVCRELPTRAAVLRAQGDDEQARTRNRRIFGSLLGTLQKFKQEEIVLQTKEEKKAQVERKIEEQARLQKEKEQKERKTLFAERENKKATIKALEVKMARVEEFEKWEKSQKDLANFILTKSRPHIYWLPKKMTEKAAEKLNSSRKYHEKCMIKKRQELQEELQRIEQRCLRRGPATKENNPSVQGTEDRKKDREDNDKIVTVKNEDDTGRKRNKFAMDVDEKDREDSDGEDRTEEVKKDKAEEDIVKENDDNKMDTTEQQEVITETKEIETEVNAMSEESTNVETQETVVQVTEHKEPIDTEHSMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIY4</accession>
    <name>A0A194RIY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIY4"/>
    <dbReference type="STRING" id="76193.A0A194RIY4"/>
    <dbReference type="KEGG" id="pmac:106708326"/>
    <dbReference type="InParanoid" id="A0A194RIY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265246" evidence="2">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="285" mass="30228" checksum="509A6829F8366DBC" modified="2016-10-05" version="1">MAPGSTVWLLAFLLSTASCQPLPDPEPQYPCAEYQPCESWEPPPCEPCPPPCPPPCPPPCAEDEIVQIGPCNPCDRPVNYLYGQAPPGSIIIRPGQVRFRPQQPITVKPGPIQLPPPAVVWVKPAPVQPEAPAPITVRPPPVQPPTPAPITVRPKPVTPPRPAPIVVRPAPVPVPKPAPMKVQPQPVQPPAPDLLVVKPPRISVPGLPVVCFQPNPPSDFRTSGSALISLYQPREPCPEAIPPCPPVPIPPCPPVPIPPCPPVPINPCPIPIPPCPQPCPIPICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJY4</accession>
    <name>A0A194RJY4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mps one binder kinase activator-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJY4"/>
    <dbReference type="STRING" id="76193.A0A194RJY4"/>
    <dbReference type="InParanoid" id="A0A194RJY4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="285" mass="31516" checksum="98FBC7BEFE29CADB" modified="2016-10-05" version="1">MVISRGALLPSEKYLRAPISGTYCLMHDESGDEMTVRHACCRKARRKEREGEPAGDPKLYLQEALLERKLPELDMRQLVELPRGLDYNEWLASHTLALFEHVNLLYGTVSEFCTAATCPDMTGPGARAYAWYDERGKKTRVAAPQYVDYVMTYTQKTVTDETVFPTKYVRVGAANEFPAQFEGVVRRVVRLLFHVVAHLYAAHFRELVLLRLHAHLHLTFAHLTALDRRFALLDHKETEVLRDLEVALRLSEPGGAPCPPTPAGGVAEGAGGVAAGAGGAEGGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKB2</accession>
    <name>A0A194RKB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase-activating protein 11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKB2"/>
    <dbReference type="STRING" id="76193.A0A194RKB2"/>
    <dbReference type="KEGG" id="pmac:106721509"/>
    <dbReference type="InParanoid" id="A0A194RKB2"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="830" mass="93507" checksum="EBD1AD5F4F3294BC" modified="2016-10-05" version="1">MLISDGINHGKLQSIIVGELKKAGLKHRLKKIILKNVKDHKTVFGAPLVKVPSCSVICCGSTLSIPNVVSEMSSVLRANANVEGLFRKAGSQTRQKDIKRLLDAGGCVSEGHHPIDVASVLKLYLRCLPEPLISAEVQDLLLRCRVTAGEDGLKPILHTLLLLPVLHVHLLHYIMELLNFIASRHKDNLMDSSNLAIVMAPSIMPLPAASSAQRLEHHVALVKMFIENSQHIGVLTEELMTQLDDDCDLHHARRKKRRSGSLNRMLSGLRKMVSGSANTPATVPEHSKTPVISKSAAKRKMEGYEGLSAKIKKEVKKNLPQRELSFTPMKMGITERKRLRLSFKDIKDTANINSETSVSSEDMLTSSENLFSAHDTIDLSPDMKQTDKDYVRISKQEYEEIKSRVSAIENRLSREFTDVIPNVQPLQHVQNAYEQTLEEVAMLHCPSSEHLARRLSKELKIRPKEQAKIIRSPSARKIGSIRRRSKENLTKIVRHKSWNVSTHSQASQNSDRFYPYGGVVARERTSTMKPESLIKSQADDEWNLSNCDNSVNNISNSSQKYRLRKRTSLAPDYNLDKTIGKLQPRRSLNITMDNSYDGISENSLNNSDKSNSNQYQYYRNNTKSIKYSNRPSQQKWRSAAAFFMEKTGEVENDSQTGRPSVNKLRQQNAGAVLAKAKLFESGSDKSSERNDKTDSNFARRPRTNGQNKPLKSITNNKSKIPTSPNIPNRLNKEYNKNYLRPYPSTSEGKEEAINWRFNRKATTPVKKIVSPQNGAPKAQTPVMKKPLCQPKSLRTPAHSGDVKKLNTPLKAVHVSPRRRSPRQKLQRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKS9</accession>
    <name>A0A194RKS9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKS9"/>
    <dbReference type="InParanoid" id="A0A194RKS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="56" mass="6630" checksum="3AF0FCA117EE9323" modified="2016-10-05" version="1">MIKLALNLPTTTRNRGRPPTTWLTTIQKDLKEIDLDEQDSRNRAVWRIRTRKADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLV4</accession>
    <name>A0A194RLV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLV4"/>
    <dbReference type="InParanoid" id="A0A194RLV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="8298" checksum="D01DBED4077D9501" modified="2016-10-05" version="1">MSSVAHIYSSRLRSTSVPNFEATIGTRSVGRPPSRWTDDIVRTAGNCWMRKAEDRVLRKALGKAYAQQWANKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RML2</accession>
    <name>A0A194RML2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_12574</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RML2"/>
    <dbReference type="FunCoup" id="A0A194RML2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RML2"/>
    <dbReference type="KEGG" id="pmac:106720612"/>
    <dbReference type="InParanoid" id="A0A194RML2"/>
    <dbReference type="OrthoDB" id="10259804at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="736" mass="84023" checksum="591F8F38D2C1576B" modified="2016-10-05" version="1">MSVNEMSETQDMSEKMPTSDQKLTLSESSQTTLCKMSKGTISLMEKRQMYRVIDDGVDVTPDNIVDPEYVLMEETHTHAAFGGRTDKAIKSDIGLKVSKSKSKTTVEVAMKVYTTTISLDDIHIDHTKDTGESFTGDEIDLEIAPSAFYMPVKKPMMEYPEEIFVVLKETETEFLFELPCFSYERGTMEANIVEEQNNYYQYITVGKGRNRKMVTEETQTKECVSQSRHTIATRPKKKNAISFASMWDMHDTYAQLAKVAKAEEPDEMVMYQSVEPKLLRKKKKVASEVTELRGKSYKDICNTQAFFDAVLLTERVLATMQFANAQKKFRGLVQFNPLALDLRYVYTLKPLWTLECNETAGRPITGISFNPRNCNIVAVAHGKFTYAETFDGLISIWCTKNPCVPERLYRFEHPLTAVAFSEKNPNWLACGFHNGDVLILDITSYSIKTVAKSKRDTNPCFEPIWHINWHFIDSIQYVITTCQDGRINRFRSTKTHDFICSPIMRMATVEGQLKGLETAKACVNVDVPIIRHPAVLCMKWHSEIDHIYFVGTDEGCIYKCSTHYSNQHIEVIRAHAGPVFNMTFSPFLERLLVTCGADNAIRLWLEELDDVIMTLNCPAAVYDVAFCPVNSTVLISVSGNVLSIWDLRRKNHIPCAEYKFPGNVVLNFVKFSKSGDNVFVGDTSGRVHTFHLEDTPIPPFYQHKILDEVIKKALCTRPQLLKQLQKIEKYKQRHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNE3</accession>
    <name>A0A194RNE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="31">Fibropellin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">RR48_12445</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">Ya'a_city_454_Pm</strain>
            <tissue evidence="31">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RNE3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNE3"/>
    <dbReference type="InParanoid" id="A0A194RNE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061326">
        <property type="term" value="P:renal tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000368">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000649">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000032">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000085">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000201">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000048">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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    </evidence>
    <sequence length="3495" mass="380273" checksum="054A75DEDAD57234" modified="2016-10-05" version="1">MTANMVPSSPSNNHYWLGLATVDDLRTNTLESAAGGLVSQYAGYWALRQPNPKDGECVDVHVTSDKQSWELTTCETLLPFMCKSDACPAGTFHCSNGRCINSAFRCDKQDDCGDASDEMDCASECHFYMASSGDVVESPNYPHKYPAFSECKWTLEGPQGQNIVLQFQDFETEKSFDTVQILVGGRTEDKSVNLATLSGKQDLSSKLYVSASNFMIIKFSTDGSVEKKGFRASWKTESSNCGGVLRATPQGQVLTSPGYPNVYPGGLECVYIIEAQPGRIVSLEVEDLELEMNRDYIVIKDGNTPSSPVLARLTGPGADNQKVVISTTNHLYMYFRTSLGDSKKGFNMRYSQGCRATIIASNGTFTSPAFGLSNYPNNQECLYRIKNPNGGPLSLKFDEFNIHPSDVVQVFDGASTNGLRLHSENGFTVKPRITLTASSGEMLIRFVSDALHNGYGWKAIFSADCPPLKSGIGALASNRDTAFGTTVTFSCPIGQEFATGKSRIVTQCQDGGNWSTTYIPSCQEVYCGPVPQIDNGFSIGSTNVTYRGIATYQCYAGFAFPTGQPIERISCLSDGRWERTPTCLASQCVALPDVSHANVTILNGGGRSYGTIVRYECEPGYVRTGQPVLLCMSNGTWSGDVPTCSKVLCPKFPEIKNGFVVDQSRVYMFGDEARVQCFKGYKLNGPSVLKCGANQEFDPPPTCEDINECISSQCNLATTDCKNTQGGFYCPCKPGFAPVLECRPVGDLGLINGAIPDESITTSAPEAGYYKGMVRLNNGGGWCGNNLEAGANWILIDLKAPTVIRGFRTMSVMRADGNIAFTSAIRIQYTNDLTDVFKDYTNPDGTAVEFRILEPTLSVLNLPMPIEAQYIKFKIQDYVGAPCLKLEVMGCARLDCADINECNENNGGCDQKCINTPGNFSCACNIGYELYTSNGTAGFKIELSETGERDGDTYQRNKSCVPVMCPSLTSPENGKLLSTKSAFHFGDIVQFQCDFGYVMSGFSSLLCTSSGTWNGTAPECQYARCVTLSDDKNDGLQVIRDDPESVLVPYRDNVTITCTSPGRHLRNTVTSSFRQCVYDPKPGLPDYWLSGAQPQCPRKDCGVPMPTPGAEYGQYLDTRYQSSFFFGCQNTFKLAGQTSKHDNVVRCQGNGIWDFGDLRCEGPVCDDPGRPADGYQISRSYEQGSEVLFGCSRPGYILINPRPITCMREPECKVIKPLGLASGRIPDSAINATSERPNYEARNIRLNSVTGWCGKQEAFTYVSVDLGKVYRVKAILVKGVVTSDIVGRPTEIRFFYKQAENDNYVVYFPNFNLTMRDPGNYGELAMITLPKYVQARFVILGIVSFMDNACLKFELMGCDEPAVEPLLGYDYGYSPCVDNEPPVFQNCPQQPIVVQTDVNGGLLPVNFTEPTALDNSGAIARLEVTPQHFRTPIQVFHNMVVRYVAFDFDGNVAICEVNITVPDYTPPKLSCPQSYVIELVDKQDSYAVNFNETRRRINATDASGEVFLTFIPDRAVIPIRGYENVTVVASDKYGNKAQCHFQVSVQATPCVDWELMPPAHGALNCLPGDRGIQCIATCKPGFRFTDGEPVKTFICETKRQWTPTAVVPDCVSENTQQAAYHVVASVQYRALGAVSNACLPQYKDLLAQYDNILNERLSQRCSAVNVNINVTFVKAMPSLLDENVVKMDFVLAIIPAIKQTQLYDLCGSTLNLIFDLSVPYASALIEPVLNVSSIGNQCPPLRAIRSSISRGFTCSVGEVLNMDTNDVPRCLHCPAGTFAGEKQKSCTMCPRGFFQNQARQGSCLKCPQGTFTKEEGSKDITDCVPVCGYGTYSPTGLVPCLECPRNSYTGEPPVGGFRDCQACPANTYTYQPAASGKEKCRAKCAPGTYSPTGLAPCSQCPRNFYQNLMGQTLCMECPTNMKTVGTGASGLEECIPVECSNSACQHGGLCVPKGHGVQCYCPAGFSGRRCEIDIDECGSQPCYNGGTCIDLPQGYRCSCPTGYGGINCQEEKSDCRNDTCPERAMCKDEPGYNNYTCLCRSGYTGIDCDVTIDPCSANGNPCTNGATCIALQQGRYKCECLPGWEGQLCEINTDDCIEKPCLLGAACTDLVNDFSCTCPPGFTGKRCHEKIDLCSNEPCKHGICVDKLFVHQCVCDPGWSGPSCDININECLISSCENGGRCVDGIDDFTCICEAGFTGKRCQHAIDDCSSEPCQNGATCTDQLEGFTCKCRPGFIGLQCETAIDECLTEPCNPIGTEKCIDLDNKYKCMCREGFTGEMCETNIDDCASDPCYNGGSCKDEIGGYKCVCQPGWTGKRCERDIGNCMNRPCQNNADCIDLFQDYFCVCPSGTDGKQCETAPERCIGDPCMHGGKCQDFGSGLNCTCSQDYTGIGCQYEFDACEAGLCQNGATCIDEGDGYSCLCTPGFKGKNCDEDIMDCKENSCPPSATCIDLPGRFYCQCPFNLTGDDCRKTISVDYDLYFSDPVRSSAAQVVPFDTGAADSLTIAMWVQYTQQDEGGIFFTAYGVSNSHIALNRRTIIQAHSNGVQVSLFPELQDVYLSFGEFATVNDGQWHHVALVWDGSNGGELTLITEGLIASKLEGYGSGRMLPQYVWVTLGKPQSDNPKAYTEAGFQGHLTKVQIWNRALDVTNEIQKQVRDCRTEPVLYSGLVLTWAGYEDIVGGVERLVPSHCGQRVCPNGYTGSKCQQLQVDKEPPRVDRCPGDLWVIAKNGSAVVNWDAPVFSDNIGVTRVVEKSGHKPGENLVWGAYDIAYIAYDAAGNAATCKFKVTVLSEFCPPLADPLGGYQSCRDWGAGGQFKVCEIACRDGLRFSQPVPPFYTCGAEGFWRPTDNPSLGLIYPACSPASPAQRVFKISMLFPSSVLCNDAGQAVLRQKVRSAINQLNRDWNFCSYAIDGTRECKELDINVKCDHRANVRQTRQVNSQPTIKSEDTYVLDAIIPVDEARSSREGRQAGDTYNVEVSFPAINDPVIHGGTNERSTVQRLLEKLILEDEQFDVRNILPNTVPDPASLQLVSDYACPMGQVVMAPDCVSCAVGTYLDSASDSCQPCPAGSYQSEAGQLQCTPCPAIAGQPGVTQATGARSAGDCKERCAAGKYYDAEAELCRPCGHGSYQPREGAFACIPCARGQTTRATEAVSAAECRDDCPPGEQLGGDGGCEPCPAGTWRGAGTGAACAPCPPGTTTPQTGASSPDQCSLPVCKPGLYLNVTLNTCIQCKKGTYQSEAQQTLCIPCPINTSTRGPGATSEADCTNPCEMSGPEMHCDENAYCLLLPETSEFKCQCKPGFNGTGKICIDVCLDYCDNGGECVKDARGEPSCRCTGSFTGRHCRDKSEFAYIASGVAGGVIFIIFLVLLVWMICARSTKKKEPKKTLTPAIDQNGSQVNFYYGAHTPYAESIAPSHHSTYAHYYDDEEDGWEMPNFYNETYMKESLHNGMSGKMNSLARSNASIYGTKEDLYDRLKRHAYPDKSDSDSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPJ1</accession>
    <name>A0A194RPJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RPJ1">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPJ1"/>
    <dbReference type="InParanoid" id="A0A194RPJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17685">
        <property type="entry name" value="RUN_RUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF13">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1575"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1371"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1516"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1556"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1634" mass="180198" checksum="85B0E3C0F3EB21CC" modified="2016-10-05" version="1">MGVTEYDWETYNGYYSGEESVGSINTMSICKSELLFSPVKEGHGVHFSVDSLDCELPAEQDLILTCQANKDNYTIAFEGSVTIYSEDSECAEPAVNQTHDKLGKEETNIAIDSDERTRRNLELLERCKKLTNKLTTSMARSDLGLTTWSKLKKQTSQSPLRRHPSGNNNGDSNDTTNVTSEMNNSVIKSQSLPNLYRRKLMSSSIASVALSNSTVDSFTVNQRLTGTSTCMKVYDVSQNRSSSHGSQHSEPMSTSSTENQTSSDKSQPKQSFNLVKLFMKQKSISNDGIVTMDQLDRSECWPSSSGGESADSMGEQKLEDLRIRSASERPQIDLPNDEGETSLVYEEIKPINTYIKTTKVIEEEEAAHGDKLSDSESNLYAVVNKPHFKRASLNVNSPSKARLTRKSCSSQSSATSVSISSCSESDGTQITRMDKVVEKEPYDNKSTSTHSDTIDKSIQTSHIQTSNVSQDRELFRVVEPSFLEKLKEGDCEKPVFVLYPNYTLPDISFLNGRPNIYLNPLKVNVSPKSTDGKKTRIQVKGKRPFSCNDMEVLKKKGLGHIKDWDSLNFLLPVECKQLLSEMPELAQHIKEKEGMSKCSDRYCNASPFSKVKNRPLSCDCNNLTGNTTAVSSSSSTATQPSSGYRGSSTMLTDSSAQNSPAPAGNFNPLFVYRYDSATSSEASCANADGQRTNHSVPKRSLSLADQTRLAKQTELAPPRPPLPKSILRKSMDKTRKSSAQTKRYSMFELDEFMQDPIVCATAITEQKTKRRSLQEPYYLQNQAPDYRKNNDLAAKRLSQQFLDAADKDADYNEYYQDEGVGTESSLESGKSNELKYYRPHTPPMPKPRTKKIEYIDFPPPGALISSADLQQLEEFLKQSGFNCQNMDEWDQNQVQKVRSQVTKFLQMKRSQEENQRSTDSSGSSCNSKKSVSFAQKSDAIVEGQPLQLKAMDDYKVGSPSTPPNSPNICAAIKQRLYQAKNLAEIPICEEGEVSPDEFNKPISHQEGRPKYDVIDISQKRALVSNVTDAVEMLIQHFSPATDQVELAFLGDSKHSPACAKIALNALCPALYAIFRDGLKESIETSFGAVDNSVWQMLEATARQGPITKSLNELILRINSEDAVTEGLVKFNAFILGLLNAQTVDAWVSYVKTRESILAKHYGPDSLMLAGCIGEPRCKALLDTLLASLEPLKLLPFSLDLMFEMRELHRSFKRIESDMRAASRPSAINTPPLTLNQRNLLKLVRSMQSSGLSSDDCLTSVIMRHKEPKNKEPSTPDLLDDSANVKTTIERHRPRSCVNPSPVGHDVCPNNSRIELEANRRWSGVQLGSKLMQAFDRLVFDDSDDYTDSLENNKPAAKAGIDLKLECSGEEWRPGSAGSCASGNTGAGSNTGGKFRRLQLKWEMLSNAESPGTPSGETSPAAARGSKIPRPVSSPVRPAAPLTVLPSPAKNAQRGIPVPVRKSTSPTTANQRTIPRGTPNAKKPPQPANRAPQEKPVRRSLGNKPATNKHTNDAVAKNTSNAKKSPTSRVDSAGWSAGAAPRPSSLPYGRAPPPAAPRRAASSSAARAHSAHSAPAKHKYVRTLWHRLPSDSGHLAFKEGERLRLVLEVDDQYLLCCRGEHKGLVPRDAVLPDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQV9</accession>
    <name>A0A194RQV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQV9"/>
    <dbReference type="STRING" id="76193.A0A194RQV9"/>
    <dbReference type="InParanoid" id="A0A194RQV9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000175">
        <property type="entry name" value="GM20388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21105:SF0">
        <property type="entry name" value="GH16255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="80" mass="9102" checksum="E7F79305B902A5F2" modified="2016-10-05" version="1">MYCECPAECPPAADGMERFACPTPDRQGRYRCIDDHVLCDGFIDCPNGEDEDRQACMFYKTTKAHLDVLADALLRWARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR17</accession>
    <name>A0A194RR17_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="16">DHOdehase</shortName>
            <ecNumber evidence="4 16">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_07438</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="16">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion inner membrane</location>
            <topology evidence="1 16">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 16"/>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR17"/>
    <dbReference type="FunCoup" id="A0A194RR17">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RR17"/>
    <dbReference type="KEGG" id="pmac:106713653"/>
    <dbReference type="InParanoid" id="A0A194RR17"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000066">
        <property type="entry name" value="Dihydroorotate dehydrogenase (quinone), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 16" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="78"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="392" mass="43219" checksum="16B075779E8F1EB8" modified="2016-10-05" version="1">MNRKQKAIKKLKSICYLTLGGSLSYQFIYFKKDFHGYYDNVLSPLSQWISPELAHKIGVLAIKYGIFPAENYDDPHVLKTKFLSYELSNPVGIAAGFDKHGDAIVGLRNLGFSVVEIGSITPEPQPGNPKPRVFRLPEDNAVINRYGFNSEGHDIVYNKIKHLDKALLNKGLLGINLGKNKLSDDAINDYNLGIKKFINIADYFVINVSSPNTPGLRSLQSKQELKELLVGINKTRKVLQSGKNPPLLLKLAPDLSLEEMKDIVAVITQKESEVQGLIISNTTIDRSSIRNKQFSTEAGGLSGKPLTNKSTEMIKTMYKLTQGKIPIIGVGGIFSGQDAYDKILAGASILQIYTALIYHGPPVITRIKKELAELLEKDGYSSVNEAIGKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRA0</accession>
    <name>A0A194RRA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FRA10AC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRA0"/>
    <dbReference type="FunCoup" id="A0A194RRA0">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRA0"/>
    <dbReference type="KEGG" id="pmac:106714322"/>
    <dbReference type="InParanoid" id="A0A194RRA0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="28923" checksum="E0FA07AE27E16FC8" modified="2016-10-05" version="1">MSARLRNLNPYELHKYLVNVYCLNKKGSTASLTRDTSRDRTDLDVIRENHKFLWEDDDVADTWEKQLAKKYYDKLFKEYCICDLSRYKENKVALRWRVEREVVLGKGQFQCGNKQCHSDKNLKSWEVNFAYLEDNEKKNALVKLRLCPECSEKLNYKSKKREVKRLKKSQKKRKKKGKCNDETDMISGDECTECLDNPPEPSTSKEPVQPEEKDESLWKKGVQEVEEKTREEEFEEYLEDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRI8</accession>
    <name>A0A194RRI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRI8"/>
    <dbReference type="FunCoup" id="A0A194RRI8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRI8"/>
    <dbReference type="InParanoid" id="A0A194RRI8"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ20082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="21683" checksum="8BE97D05866F8C9D" modified="2016-10-05" version="1">MTKAYLNDLLPWLQEKGICNLFIVLGDSFNPNRSDFKTSSEMISYIKAKTLDYFCIGVAGFPYDDCKITALKEKIDLGADFVISQAFFEANIYKNYLEKCKDAKIDVPIIPGIFPFQSQKELDMFLKLCKVEVTDEFKMKLEGENVMDIIENLVLDLHNNLNVKHFHFFTINKLEITCDLVKKIQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSC1</accession>
    <name>A0A194RSC1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear factor NF-kappa-B p110 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSC1"/>
    <dbReference type="FunCoup" id="A0A194RSC1">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSC1"/>
    <dbReference type="KEGG" id="pmac:106720577"/>
    <dbReference type="InParanoid" id="A0A194RSC1"/>
    <dbReference type="OrthoDB" id="10254686at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF28">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="944" mass="106404" checksum="52AA52E8C7C054E5" modified="2016-10-05" version="1">MSASEPDISESSNLESPSPHSDSPYSSPSQQVPQLANFLTVLSCGDNKFNYDTGNKPFLRIIEQPQNHFRFRYKSEMVGTHGSLLGKSYALNKTKTHPTVELVNYNGQARVRCRLAQHNNSDEHPHKLLEDDQDRDVSATVPEHGSYKVGFPGMGIIHTAKKDVANLLYKKYESKGKNTQDESSSNMLRLHCENIAKNINLNIVRLKFSAHDYNTDEEICSPVYSEPIHNMKSAATNDLKIRRMSRCIGRPKGGDDVILLVEKVNKKNIKIRFYELDKNGTECWSAEGHFLQNDVHHQYAIVFRTPPYRDTKITSEKQVMIELMRPSDGRTSEPKEFTYKPKYVHTNAKKRKANSSYSSLGSSGGSINSLSDLPVPIQMMHQKNEVISHDAVMKDLPMFNIPVSQISAAPMTNDMLLGEAMFDLSSMTPNSGVSQQFNVSPMLGQPNIPEPPVLQLNSSEIERLIKHNSNITAEEKKQFCEADWTDYFKSYGDSVPDMMSGMEFIRLVPDSARVNIKTSRPASPKPMKTEEDDVKYNLENLKNNEYSAYYKSEDGLEVKKLVMELCDMIKNKTAHKKQLVRTKLERLFEMRLSNGDTFLHMMLSSNQPSLEYIVKLIDSVKLTHLLNKTNNNGQSVLHLAVTHDLPKLVTFLVSKGCNPMIEDNEGNNVIHYAVICQTCLEPLLDAMKMNQISFDINAYNNEKQTALHLAAIYGSADSTRVLLGHGASMHARDSEARTALHLAAYDDCLAVLQVLLEYAQPSDIDAVDGRGNTALQIVCGGAMRENSIEIVKLLMDKNANPNKNEDNNQPAWRMARDKPELQQVFKKYIPQMMVCEDDIKSEPEDEYESADEGEIVESCLPELSLYVEEVSKLLDASGGWRELAQRLQRDSLLSWYSASPSPTRKLLTYLKDCDDDITSKSLALLLEDMGQKEAASVIRRYLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RU38</accession>
    <name>A0A194RU38_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_06496</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0645">Protease</keyword>
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    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
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        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
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        <location>
            <begin position="430"/>
            <end position="607"/>
        </location>
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        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    <sequence length="1275" mass="144648" checksum="30CE6FE63E87610D" modified="2016-10-05" version="1">MSTSNPLTLIEKLSGRENYSTWKFALKTYLQHEDLWDCITGSGVVDEKRDTKAKSKIILLVDTTNYIHIQDCKTAKEVWDNLAKAFDDSGLTRRVGLLRELCTTTLQACQNIEEYVSIIMTTAHKLRNIGFKVDDEWLGTLLLSGLPDSYQPMIIALESSGLKISADSVKSKLLQDIKMNERQSSSAFATNKSFKKTAFYKNKTGKQNFQKGPRCYSCNKYGHISTDCKTKKITKSSSYAAAFTATNNNSDAWYIDSGASVHMTRYENLLSNTSESLIKSIKVANDKSLNVKCSGQVTLNVSDQRGQHRKVLFQNVLCVPELATNLISVSQIIRNGGQVKFNSKGCVILNKNNNVVATAILVNNMYQLNMYSEHAYISDVDENDPYLWHQRMGHLNFNDLNKIIENTEGMKVLKKKETNLTCITCLEAKQTRLPFKHKGTGTTKLLELVHSDVCGPMETESLGGAKYFLTFTDDYSKKIFVYFLQKKSEVIDKLKEFKKYVENQLECKIKCLRTDNGLEFINKNISDLLKGDGITHQTTVPYTPQQNGVAERLNRTLVEKAKCMLLNAKLSKQFWAEAVQTAAYLLNRTPTKSLKYKTPEEMWSGTKPSVSHLHIFGCEAMVHLPKEKTKKWDPKAKKAIFTGYCTDTKGYRFIIPSSGLVIKSRDAVFLESTVVRNYVPVDLTHSEDKSVSEELRHSSESTSTNTIASPEESESDESMNSSIYVPDRKIEYPMSSNVTLRPRNKQSQPKTKSFESYLCYNDGILDVPLTYSDAITSADSDKWKMSISEELQAHSVNKTWTLVEKPKNAKVIGCKWVFKVKDEPTGLRYKSRLCAKGYAQTKGMDYDETFSPTVRYDSIRLLLSVAAEQNLEILQFDIKTAFLYGELSEQIFMVPPDGLQCAPNMVCKLNKSLYGLKQAPRCWNTKFNAILEKFGFVKSLADQCVYVGQVNEIKCYLCLYVDDGLLISKERLILKKIVNELQTHFDLKTCSSNNFVGMQIERNKEHIFIHQTKYIEKILEKFNMDSANPNSIPSDPHIKLQKGDAVPARNLPYREAVGSLIHLATVSRPDIAYAVSVVSQFLHNYNESHWNAVKKIFKYLKGTIEFGLCYQSKPQSTELIGYSDADYANDIETRRSMTGYVFIKNGAAVTWSSQRQQSVALSTTEAEFMAACAATKEIMWLKQLLCDIGQYKQVSVCLNIDNQSAINVIKNSEFHKRCKHIDIKYNFIKEKYQQNVISLNYVNSVEQFADIFTKSLPRERFKLLRSNIGMLSLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAP4</accession>
    <name>A0A0N0PAP4_PAPMA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="32" mass="3650" checksum="A4F80396F0746F59" modified="2015-12-09" version="1">MLVILAFIGVRFALHVSRQSARALAEECYTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBL0</accession>
    <name>A0A0N0PBL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemicentin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N0PBL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="359"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="561"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="649"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="744"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="825"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="987" mass="108942" checksum="BDDB35B62988CB69" modified="2015-12-09" version="1">MATDIAEVKSKTKLIFDTVRNSAESQIENFILVTFNDPDDTLSMATDIAEVKSKTKLIFDTVRNSAESQIENFILVTFNDPGFQPALVTFSESVFKAALDAIVVHSGPDNLECPEMSMHGLAEALAHTLPGSYIYVFTDAAAKDYADGPKIKKMAQKQGTQVLDFVGKSLDKRRAVIGRAELPPGYNNNITITGDKEIRDVQFSVTGLKPKLKITKPDGNEVNTTDIFKNDKTLVVGVDGLGSGNHTANVGSESDTSVIITGVTNVNFQHGFSEFKPRSINTTVTRPIQGKPSYLAIELSTKAKDFKLDEVELLDMNDNVISVWPLKEVATNFYVAEQQLPPTTMFRVAVNDKPENRRPTVTLIGDTSIAVAYGDPVQLQCKINAYPKPKLMWIEEKSGLTVSEMIVEEDLPYGYISILDLEQVKTNNSYRCRAFNDYGDDTTKVSVGVNSKVPPKIDKSVKQVNVTRKESATIACNVTEGIPQPDIRWSYKRPLTRVFIPLDDKSDVIQINTTELHNAGIYKCEASNLFGRDEHQIELVIKYPPTIRNNKQIVKATEDPPTIRDNRQIVKATEGQRVFLTCNADGVPKPDVRWYFKGHEIGKTLKFRIYARNTLSMVVSFNNSGIYTCNAVNEIGSDTKEVKVVVDGPPFIETSSVPKTTTAVVGDLRVNLPCLATGSPEPTITWAKDGVEIPSGTEWYNIKKDGTLVIKNVTATSQGRYVCTARNSKGIDTDYFDVVVQPYPDATEKRNVVNLLLGSSATIECDVPHTTNDRLIWYKDTEIVATGELHLKDVEIESSGVYICRVSTLSGAASATTELNVGFPPEFLEQSSEQTDFDLNAEAYFSCLAAGEPNPTATWLHDGKDLEITDMDYRVYMTFNDLGHYKCTVSNLYGTITRDFQIIDTGCTLVSGINNDSPVISLMEARLLSDNVSILKVSKGDVVTIICENGFEKYPGTEVEAVCVEAATVRIIDVEINLSDIKCKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBN5</accession>
    <name>A0A0N0PBN5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBN5"/>
    <dbReference type="InParanoid" id="A0A0N0PBN5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1122" mass="127429" checksum="9274E28292B84265" modified="2015-12-09" version="1">MDLKTANNETKSRSQTEEYWSEHFLSKFGLEYIKHNILNKRSFKKKDTILKDFDLQMPSKEGCTSIQPSYPRRSSRTAISLTQAPVEKQLQSSESELSDEEAHQLEVKAIHKIAQVLHIEADEKNITDMCIQFRREILLLLRRVVRQCFLIGWDMKIKWQLDFALLLMPPWLRTVEMELMMLPQAVVSHKDVGSETLSGTYDDSDCETCSDGVRDDVSGDDAHDKFKALLEEGGSVKFSLWDTFDANDFKKVALLGFSSLVYIQRQWYELKQLARSEVLAFHLQHSHTPPHPLLLSIVANFRHIVQEPLPKWSDFVTSKMVVKFKDISKTISKKVLEESMDELNNAREQADLINGEINKLTENTISEIYLVNNKNIIEKESQSNNKSDLIDTNVDKQTINNNEFIVNVNSSVAIKKNLDNKNSLITNNTIECNEIDLNAVLNNIDPTKAQKHLIFDSDSDSETLSVVSQMEYSNNISTEKQTYFETELNSGISQNNKHSKLCKQLSVNLHRFTNEQRTMCRRKKKIQLTDIEEVRKINSTILTAEVAPVSISRCDSPSEADSFGIFSEEPTREITNYNVIDALELDELFKKLPVPPLTPINLDKSMEMTTNTSSAALCHNDSEQNKINKPNNKVDESYDELNDKILSIIMKSPVHNQSKLPVNVIAIRDSSDSDDNVRFSAVIDMMNDKRKKRQNRERNTQKQSKKKRKRKSKKDNSECKETECTNALEEWGRQKNLTKKYFQLPNITSKSSNECAIQNTSTNSSNNNILLSTNSNPYTNTSQCMSGNQNTPTLPTDKPSPVIDLTEGPDNTQLDQNSDTTPIITNVYSLATHTDKQDEVTQLKKVITPILVPHSNMINTDLGSLTGVQVANVGSEIVHSIPQANTLVPMNVPGQQIYVQQSPLTQYTSETAVEIEPAPAPLLLMPLMPLDLWVQGKSVKELVILQIDASKPSWTLTGGHTAVTLTDYTCESPIYCSLPLSMKTRIIFPQENNGTDVYNPLTLQIYENVANGTSPFAKWVKSVIDNTENDYIDNCANNCNVSKTQTKDDKCEIDRPVSRIKVKSFARLTEMQDGNFIAPERVCLQDRLYMKVSEQPLKYAKVSETRFIPARDYLLEHNFRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCI1</accession>
    <name>A0A0N0PCI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fat-like cadherin-related tumor suppressor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_02685</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCI1"/>
    <dbReference type="InParanoid" id="A0A0N0PCI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF28">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857373" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="261"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="374"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="481"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="741"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="846"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="948"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1060"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1165"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1341"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1495"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1280"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1295"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1612" mass="174737" checksum="0FE5EDE287B19CE8" modified="2015-12-09" version="1">MAGGRRLRCVALLLAAAAWCAAGPGPPALRFPRALYNLTVPENSPPRTYAEPPPGAEHPAHPAVPLPSPDTKIRFRIRHGDRDKFFKAEERIVGDLCFLLIRTRAGHTDVLNRERRDTYRLDVRATAQLSDGTQLEADTVLVVEVTDENDLSPLFYPTEYEALVPEDTPLHSSIARVTAEDADLGINGEIYYSLAELTDRFAVHPSSGVVTVTCALVAAEKTRYEITVLARDRASLLTLGENAPAARATLTIRVAPVNLHAPELRVRRLPELVENSTAEIYAIVEVTDRDVGEHGRIAVLEIVDGDPDGHFRVRPSEQPNEYDIVVHALLDRETSPRGYNLTLRASDAGRPPRASYLTLPVTLVDANDNAPVFSREIYEANVPETAPPNTPVIRLKVSDRDEGRNARVYIEIVGGNEGGEFFVNPDTGVLYTAVPLDAEQKSLYTLTVSAIDQGNAGTRKQSSAKVKIGIVDANDNNPVFDRDDMTVTLAENGPTGVVVARVSARDADSGENAYISYSVANIQPIPFEVDHFSGAVRTTKLLDYESMRREYVLRIRASDWGLPYRRQAEMRLTVRLEDVNDNRPQFERVDCVGYLPRRLAIGYEIVTLSAIDFDSGDVVSYRLVGGNEDNCFALDSGTGVVSLSCDLADVRAETRVLNVTATDGTHFADPTSLTLHLVGGAGVGASAGEVGALECRDTGVARRLIELLAAAERSNAPIDFTEDFPLAPSRYGENLHAPEFIDFPVEVKVNESVALGTSLVRLHARDRDLGYNGLLVYAISGGDADSAFRIDPDNGELKVIGYLDREKEHEYYLNITVYDLGVPQRSSSRLLPVTVLDVNDNAPKFVKTLSSFRVTENAINGTVIFRANATDRDAGEFARIEYSVTGASAGEFCVERESGLLAVCAPLDRERHALYELSVRATDGGGLRAEALVRVAVDDVNDNAPRFALPSYSARVREDVPVGTPVAVLEAFDPDLGAGGLITYSLPDQATEDVVFTVDSTSGTVRTAKRLDYEEKQTNGKNLQVVRVQDGGQPALWAEATLVVEVGDVDENRHTPAFAERAAVALAVREDAAPGARVGTLLALDADPPGRDSRLAYYALDGPGMAHFAIDDTGVVRTLAPLDRERAPHYWLTACAEDHGLVPRHACIQVFVEVLDVNDVAPWPERAAYFARVPEHCAAGTRVAVVRAPDGDAEPRAVHYSIVAGNPDGLFAIDDRTGEIVTTGRALDREAASAHALEVRAWDGALAANVRVRVDLTDLNDHAPAFTQRFYDLRVPAPAPAQEDEITTEGLESSAEGEAEAEGEADAEAEGDSEAEEEERGGWDEWDEWGESDSGYVYIATASDPDGDPLYYDIVDGDPERQWAVGREDGSLVLVRGLQWERRPHYALNVSISDGRRALYTTVNITVVNDVHEGGVEFERELYTVEVSESARAGDTLVALRARVRPAPGAQAGAAPEPRLLYGILAARVPADAALFRLHELTGVLELARPLDRFASEEVQWEVAEDAAVGTVLGSVEARSGTAVWYELRGGAGLFRLNPAAGVLALAAPLDYETCARHDLVVTALNMGGGAASARVTVHVLDRNEFAPVLRARAYRGRISEAAARGALVCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCP2</accession>
    <name>A0A0N0PCP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phenoloxidase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCP2"/>
    <dbReference type="FunCoup" id="A0A0N0PCP2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCP2"/>
    <dbReference type="InParanoid" id="A0A0N0PCP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006583">
        <property type="term" value="P:melanin biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000004">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1520:FF:000001">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF24">
        <property type="entry name" value="GH04080P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="652" mass="75582" checksum="FC0DAC60370E040E" modified="2015-12-09" version="1">MEDIKKKNLLLFFDRPTEPCFMQKGEEKVVFDIPDHYYPEKYKALSSSLSNRFGNDAKRTIPIRNIALPNLNFAKQLPYNDQFSVFLPTHRQMAGRLIDIFLDDTKGMNIPTLTETFPDKFMDPKVFRQARQSTNVVKKGPRLPVTIPQNLTASDQEPEQRVAYFREDIAINLHHWHWHLVYPFDLSTGGIVDKDRRGELFYYMHQQIVARYNIERFCNDLPRVVMFKDLRAPIEEAYFPKLDSQVASRAWPPRFPGSVIVDLDRPVEQIKIEVSDMERWRDYIIQAIEENAVLLPGTSGRKMPLNPETGIDILGNIMESSILSVNRGYYGDYHNMGHVFISYVHDPDHRNLERPGVIGDSATAMRDPIFYRWHAHIDDIFQMYKNKLPPYTRNNIVYDNINVTSIKVEGPAGTNVFGTFWERSTVELGRGMDFTPRGSVQARFTHLQHEEFNYVIEVNNKSGNYAMTTVRIFMAPVFDDNGNTMTFDVQRKLMIELDKFTQSLKHGMNTIRRRSLDSSVTIPYERSFRNQLNRSGTAGDQSVAEFDFCGCGWPHHMLLPKGTTKGYPVTLFVMLSNWDDDRISQDLVGTCNDAASYCGIRDRRYPDRRPMGFPFDRPGAPHVKNLQNFITENMAITDCTIRFTDEIRDRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD24</accession>
    <name>A0A0N0PD24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD24"/>
    <dbReference type="STRING" id="76193.A0A0N0PD24"/>
    <dbReference type="InParanoid" id="A0A0N0PD24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="154" mass="17551" checksum="DAC79CA6748B55F5" modified="2015-12-09" version="1">MHGCHGNDGSFRFEYASDNGLAAGEVIEPDGSRVGAYQYKDPSGQLVKLKYRAGKEGFQILEGSHLPQSPQPQQPDNYYQNAYAQQKQYDQQQYTQRPETSQDWTPQNQRCYCRAMLRRPHIAQGIKPRSHLSDVSCRDAFCRDGYCSHLCDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE40</accession>
    <name>A0A0N0PE40_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE40"/>
    <dbReference type="STRING" id="76193.A0A0N0PE40"/>
    <dbReference type="InParanoid" id="A0A0N0PE40"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="25801" checksum="2CDE465F86965B33" modified="2015-12-09" version="1">MSSMHSDDDQEEINVDSDSRLSGACDRSVASEDRDSEHSYHTYHNSPNEHMTDTQQRVNLPFSISRLLGKQFEDIDKRNSGESDRSDQDTESESAKDEARDNSGLPLNFSHNPALYPNSGLLLRPGLGLGGGYGFSGSPGVVRVPAHRALGALGAWGVALDPMRQAAAAAFAHQVVKDRLNVNRFTFGPHDMSKKIIDIVKYRDKTALLRCLAPAFPPGKWESGYENLTRTNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEN1</accession>
    <name>A0A0N0PEN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysosome membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEN1"/>
    <dbReference type="InParanoid" id="A0A0N0PEN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF104">
        <property type="entry name" value="FI07620P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="522" mass="58507" checksum="D62FA54A428AFB92" modified="2015-12-09" version="1">MPSSGRYEAEMECKRFQFHFYVLRLYSRYRYPSKCKSDFAEKLVTRATLGVALVVLAVTALAIDPVVLIAKYQLRVTPGTEMYRMLTSEIAGAYVSAYLFNISNADAFLSGADSRLRVNEVGPFTYQEKRYNTHFEVDGEGQVLRYRPFINVTFVPEMSVADPADVNVTVGNTALLAIATAMSTHPFWSQLALNLLTRRYNSSAVVTLSVHDLLWGHHEPLLAFGHTFMPGWINFERLGLLDRLYDNTRDYQLELSLEDQTKFQVRRVNGRAGLTAWSYNDPNKRSRCNTFEDAYEGFSYPAGLTRERPIRLYRNVFCRMLEVDFSGSKTLDYGPEFCLASLTNSISLISGFLKFNFPKGLPVMMSNAHFYGAPASLYARIDGIAPDEHKHGGVFAIDQKLGSALQTSMTFQLNVPVANVAYNKEARPFANITVPIAYFKVTQPEVPEHVKTMFWLVYVVGPYAVYALAAMLGAAGLGLLAAAARLLSAPLPLTKQAIAHVHCELPLIKHAHKQTILSDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF91</accession>
    <name>A0A0N0PF91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01010690">
        <property type="protein sequence ID" value="KPJ20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF91"/>
    <dbReference type="STRING" id="76193.A0A0N0PF91"/>
    <dbReference type="InParanoid" id="A0A0N0PF91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8219" checksum="0380032F0F882EF4" modified="2015-12-09" version="1">MLLAAGASQTLATEDGFTPLAVAMQQGHDRVVAELLESDTRGKVRLPALHIAAKKNDVKAAMLLLELRWVRVAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG61</accession>
    <name>A0A0N0PG61_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_00975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01064520">
        <property type="protein sequence ID" value="KPJ21652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG61"/>
    <dbReference type="KEGG" id="pmac:106707271"/>
    <dbReference type="InParanoid" id="A0A0N0PG61"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000093">
        <property type="entry name" value="zinc finger protein 668 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ21652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="407" mass="46586" checksum="29228CEDB382C813" modified="2015-12-09" version="1">MATPVRTVNIVPLPKVKKEISDDEDEDTVSCKICYKHFVSEVALRNHARMEHTEIYINGDPALWTKVATKKPSIPKTEEKSVEEKTKELLASMISTSITKLASEDVSYIIVKSEETIEEKDQIKKKKVEKIDKDKSEKQKVITPKKDRDPQPITGPFECLQPSTLVAEGTCHQIFFSCCEYSAHFRDEHTRRRKGLRCQVCEKPLNAVADPQAMYSCGVCGVGFQTNKELSDHSSQAHVKLKPFECTICHKRFTQQGGLQQHTRMHTGYRPFSCTICSKTFTQKSGLQQHFRIHTKVRPYRCVICNKTFCQSVHLKQHMRTHTNVSPFQCGICDKRFKQSSHLNYHLKYHNPLNMSDEQKKKYEELVGLIGDNPVELCEPQLGDDKNETGDESWCVTFVDANNVTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I763</accession>
    <name>A0A0N1I763_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysosomal-trafficking regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I763">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I763"/>
    <dbReference type="InParanoid" id="A0A0N1I763"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="4">
        <location>
            <begin position="2730"/>
            <end position="2839"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="2844"/>
            <end position="3142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3319"/>
            <end position="3360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2087"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3400"/>
            <end position="3426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="3549" mass="386701" checksum="5BDCBC875F945F42" modified="2015-12-09" version="1">MATEEEPDSLKIYWDHFFKAETGTYEKSTWLELFLAEFLVRLQEGVDPNQLIKFCPVSGVVTLVGCELLCGIHRVTSAANLHHAAPPPPSAPLPALHSGNGIANGHDGDGGGACGARAPASVFSRAQAQAQSSGAVLRAYVLRGPAWRCLVLLRTLGVEGLSCCRQLSSVLVWLWGELAGGAASPGAKPPPASHTPPIHTLFSHRIWTKQKLNQAPKTSSIASSVRSSASGRTKHNGVSKLDSNDAKSNRRSLAETEQSTESADSNDDLHILNKSMAIKVSAPSDQFEYFESPKRSSNDYPNEMLYTDPFYTPRKSKPKADDYINDKHKEIINTEISSFDFMLLITELLQELCKAESSLSGAEGSQISMQCINFSLKNLCSLQFGSLPAQANYNGEEMSRIKLALTELLIVSLDKVLIHSGLCAKLINSGILPMLLRILEDVICKSNAKYNTKEDRLSQPKDVEKSNENEAENLLKYVFGIAYSITAFFHCLLMQCRTVDKLREFTDQFKLYGECLKGGLLKECIELMIRIPHAEEETSVILIKKLIESIGKLVSGMKRVRSEVIHSAACGRSWHKACRPRVAAGMHHHHDVLGEAGPGLPLPSACCVSVLYGTLTALVTDDRVSAQPELRTKILRVMLKCGVCCCFSPGFLMECIVRLMLTHNSVAPRCLQLLEHTVYGDLGSSILIPRVTDQLPCSICEPCDDNKDLGRKYCHHGVSPIERKSVWSFLIHYNSLLQLDNHNNVLHAAVSHLLKVTPKCRMEMKYELLFSVIYPTFIVSKHRYIIKREESAYFLTVSCLNIFASLLNTVSFAEQFIQKGGLSYVLELVSLPEFSNQCCAILEIAIIVEIYKLMKENAELTYFREISSLASVQMLFKCLSEVTERCYNMYKLQLPADKFEELCDLTREKEILDMNTELEERFSTTNNTLVSNDKAEESSEDYIEALKTIGTFWKSCAGLCLLCPMFREHVSRAPLLAHSYALLKLALHRLCQPAPSAAPAETRLLVALMEALLTVQFAVSDPTKGRSRTASCGVVRSALRAATAATAATAATANTTPAMCSGAGLSALCDALIGVAVARPSRRLAMPRLAPAKVPPLQCESSGSSVEGSSGEEAGPLGSSHASPYASELSDPHPLDDDGYEADVEAGKLAAARGAPRDLAHTMSVLGGLSEYQSPMEALCGGHAAPGPGLAHPELCLVVVDILSQLLQRVVEEESNNGTQESLERVCGGLARALAARLAGGGAPAGLLRRLLTPPAAALLRRTDPRLAELQHSILELIHVVASQSVEPRELAALLQLAAADRPPLAALLSALQRLLAHADPCTPDFALQFPIQLSPHASDEPTTSLGAGAARCVVDGANWGPWLQGFALVLWLQPLPEAKNEDYDEVDRAVPMRQETGEVCGEPAAAAVHVLSLGQDSLTFELWLNVATANNVVCGVRRAVCAAVSWRGRVRGRVRGRVRGRGGGGRGGARVLCEGSAACRLRPARWSCLALNVREAVLRRKIHIQVTFYLNGRECDTVSLPLQGILVRKISATSVSLGQVSGAGAGAGAMWRLGPLALYRAAVLSAPAALHLAAHGPDHACQVRCEEPNYSAILTPDVLDINVDWEQVFEMPMAALRELHDQLLATYSAHAHEHVNLYQQVSAPQTVSGFSGRGGGCAGSGVADTLHVQWAGPAHVQRHRGFAPALLLLGGPEILLYLFARVFEMPAAALRELHDQLLATYSAHAHQHINLYQQVSAPQTVSGFSGRGGGCAGSGVADTLRVQWAGPAHVQRHRGFAPALLLLGGPEILLYLFARVVEAGGSAEQQAAALGVALRAGRADARLHAALYARDALQLLLPVLAAPACRVSHHMLKEILDVACTGPLLSVSGQSVRLAARADCALREPRLLLLLLRAWPHLHTVQVSWEVEGGEVTENGSLWALALEAICALLRDGPRRAFNQHQAARAHLLRHLLLACKERFLNSDSGPLSTSASNSLVELVRALVGTPPLPAHLALLCDFLLLMHQASDTFVTHSRANFYFLLTAESPEASEFNFLTFMNKRKNKQHKLRKSLESLALNDPPEESNAGADNTKHMKGIINAHIRDSRKENGAATQTNGTTIGEGGEGGEGGADALSGYVLVDEDELRHTTVELYTGGIYHQRRVRAGAEPGWTACAGVLLLLRDSLAALPDHLLAQQTVCGPVLAESLVVLANHRTACVRAAVVRCVCALQRRAPRALAHTAAGAHYYTHLADQISLYPGSWELATACAALLTKCDVPLEDQLDDDIWVELGEEAAQRGAPLLALLPVSLHSVPLAHNVTLLLRRLVHKVSLKALTEVALAEVVVRAVRDLGRMDEEFEGRDLLLEDLFDLLNKLAVKALANNHTMQCAVDIHQQLRYVSGTARGRGAAGVRRLARAAEAALFAAQLDHLEAHLDHCYATHNKHTNYFANVLGGAESGRARSELCARYSGTLARALAFLLARSPRAALHATSRPRTPPACTKYVPLSAYLLIMLQHIHAAGGAGVELAITDWARDWAVATQAGLAERLPCDALPAEAERFLAEDEERWTKAGDGPRQRAAVGKAVFTREVVAARCTESAMAVTRRVVEAQNGERKHFLEHLRRAHAAAALAAARWRRLIDTHTHERGQCTTRETPQLDLQFTPLSIYYVFSLGVWHNPSGWPAAWQLDSTEGPGRVRVRLRRAHLRIPARCFQPHARYKAEAATQPGPLRSVLGPLLSGARHGGLAARLQPTESVAFMARVHHVTVDRETSGELLLSDRCIHFVPEWCGEEGEEGAEGAEGEGSSCAAQSWALGSVARVCPRRWCLQERAAELFLLSGHAHLLAFAATAERDAFLRALDAAHLPNRTEQESLSDVMNQWRNGTITNWEYLMALNGLAGRSYNDLMQYPVLPFIIADYTSKMLDLHDPASFRDLSKPMAVQNKKREQHYINTYNDLKAARREGCSPLLSRQPHHYASLYSNSGGVLHYLVRVPPFTELFLNYQDNNFDMPDRTFHSLATTWRLITHDSPTDVKELIPELFYLPEMFYNDEGLELGVRQCGARVDAVELPRWAADARLFTLAHRQALEAPLVTERLPHWIDLVFGYKQTGQAAVDAINVFPACTYYGFDPSVHEDEVDRTAAQAMVRTYGQAPRQLLRAPHPHAAPDLAPRTQVHHRRAHTTRAHTTQLCLLRAPHPHPTSRRAHSNISTEQMLYTESDLEGSMDRIETINFHEEKDVRGVRFWAYNAGHVLGAAMFMIEIAGVKVLYTGDFSRQEDRHLMAAEIPTVHPDVLITVTQVSTSCTVGSWSWPAFVGLSSGRVLALRATGAAGGGARCSVRQLLAHRAPIAALCVCARATLLVSADTTGLLLLWDLNRLSYIRTLPNRERLPVTQVAVSETLSDVASVHELRPAGPRVADHTAECAETAEPPEPADAAPEDRESDGDAYERDAPHKYQSLIRVHTVNGRFVGSVKVSEVVTCICYSNAPEGASVNCIAAGLRSGEVRLYSSWDLQLVRSLPAPQAAPAPLLSLSYSEDSLVLFAAHAGGLLLAWESPHARAQPPRIVLATALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7E0</accession>
    <name>A0A0N1I7E0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha-ketoglutarate-dependent dioxygenase ABH7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7E0"/>
    <dbReference type="FunCoup" id="A0A0N1I7E0">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I7E0"/>
    <dbReference type="InParanoid" id="A0A0N1I7E0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="16014" checksum="84836B0B0F7FE3B7" modified="2015-12-09" version="1">MRINATSSMRIYPNFVSEEEEASLLAEVEPQLKRLRYEYDHWDNAIEGYRETERDSWNEQNAAILKRVRDTAFQPNAQLLPRAHILDLAAAGDVSRYEFTHAVLGGEHSMWRGEKLPRRRRIAVICRERPLPEHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8J4</accession>
    <name>A0A0N1I8J4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I8J4">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8J4"/>
    <dbReference type="InParanoid" id="A0A0N1I8J4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="459"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="719"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1184"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1184"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1220"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1277"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1314"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1367"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ15409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1542" mass="176567" checksum="CFC3750CACE29296" modified="2015-12-09" version="1">MADIRTMINKMQSATQNGTSEAAPPAKGQKGTIEKIYQKKSQLEHILLRPDTYIGSVERATETMWVFDKEKECMVQKELTFVPGLYKIYDEILVNAADNKQRDSKMDVIRIDINQEQNTISVYNNGCGIPVVMHKDEKMYVPTMIFGHLLTSSNYNDEEEKVTGGRNGYGAKLCNIFSTKFTVETASRQYKKHFKQTWGCNMTKASEPKVKEAGKDDDFTKVTFSPDLAKFKMDKLEDDIVALMSRRAYDVAASSQGVKVYLNGERLKINKFKDYVDLYIKGKEDENGQPLKVVYEKVNDRWEVALTLSDRGFQQVSFVNSIATTKGGKHVDTVADSVVKNVLEVLKKKNKGGVNIKPFQVKNHMWVFINCLIVNPTFDSQTKENMTLQAKSFGSKCNFSEKFINAVTKSGLVESVLTWAKFKAQTELVKASGKKQSKLKGIPKLEDANDAGTKNSHLCTLILTEGDSAKTLAVSGLSVVGRDHYGVFPLKGKPLNVRDASHKQVLENVEINNLIKILGLQYKKKYNTLDDLKTLRYGKVMIMADQDQDGSHIKGLIINFIHHNWPELLKLPFLEEFITPIVKATKKDKEISFYSLPEFEEWKRETENHHTFNIKYYKGLGTSTSKEAKEYFQNMERHRIKFRYSGPTDDHHIELAFSKKGADQRKEWLTNHMDEVKRRREIGLSERYLYTKETKAVTYSDFINLELVLFSNGDNVRSIPSMVDGLKPGQRKVIFTCIKRNDKREVKVAQLAGSVAEHSAYHHGEQSLAMTIVNLAQNYVGSNNINLLEPRGQFGTRLCGGKDSASPRYIFTLMSPLTRLVFHPHDDPLLIHEFEDNQKIEPVHYVPILPMVLVNGAEGIGTGWSTKIPNYNPRDIVANIRRMLDGEEPTTMHPWYKNFRGTIESFGDKYVISGEAAVLPGEKIEITELPVGTWTQNYKENVLEPMLGNEKVKPLISEYRGRFKRREVEAEGIHKVFKLQTTISMTCMNAFDHNNCLKKYDKVEEVLREFYDLRLRYYSRRKDFLEGQLQAEADKLTNQARFILEKCDKGLVIENKKRKAMVEELIKRGYAPDPIADWKKRASKMQGLDIVEEEEQESEEEVEPEDNKGKPVDPEKAFQQLKEVKKFNYLLGMSMWMLTKEKKDDLLKQRDQKLSELEILKAKTPAMLWREDLDAFLVRLEEVEEKERNEENTVNKKSSKAMAADKKNRKSLFDIIPSENGRRIEPKISEDLIKRIQAAEKAKTRKEIKKEYDPDDPTGVTPPTSGEKKPKGRVKKEKPEKEKAEKTEKTDGLKQTKLTFKKEPKKKSQHYGKRRFENNEEGKGNFKRNRDGKRFNKNEDSNRQRQGKQKVQKYKDGSEESESNEELELHDNKVDSEGERPRALSLSDDDDFNVKKNANKKPAEMDSDCLFDSLIEDTKKEQPTNNHNSEPTTILSSEEEGAPLSPPKKKPAPKRKLLNTNSKDKKEDKPKKRPAKVLLSADSDDDSIFDTKKDKKANPKKKAKKKADSDSEDEDVISSSPAPRSKARARPQAKYNFSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8U6</accession>
    <name>A0A0N1I8U6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ectonucleoside triphosphate diphosphohydrolase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460655">
        <property type="protein sequence ID" value="KPJ12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8U6"/>
    <dbReference type="FunCoup" id="A0A0N1I8U6">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8U6"/>
    <dbReference type="InParanoid" id="A0A0N1I8U6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="564" mass="60538" checksum="714813E7D313259A" modified="2015-12-09" version="1">MSDLRKRKLKESSSLGPVSSRSISLKRPRRLKRVFILLIVVAVCGTYLMGLLAGQPRWLDGLAKSLGYESAHHYAVVIDAGSSGTRVLAYKFRVPFAVFGEASLDLVEEYFEQSKPGLSSYADDPEKGAESVVSLVRKAEGLTPAAERARTPLLVRATAGLRLLPPHKAQRLLEHVARALARLGYAAAEGGADVQIMDGSDEGVFIWYTLNLLHDLMSGETMAALDLGGGSTQITFQLQEEEAARAQPADTRVLRAGAANRTLYTHSYLRLGLLAARHGLLLHEAGADRDNFTTVCVDPIVQAEPWTYAGRRHLVSGAPRPPGMKREAAYARCHALVRAHTLRTLGAPPPRAPPAAAAMSYFYDVAADAGLIDVMSGGRVSVAQYRAAAVRACSAANVDQPWACLDLAFVTALLHDAYGIRDDDHVSVSPRPFRPSALPPFRPSALPPFRPSALPPFRPSALPPFRPSALPPFRPSALPPFRPSALPPFRPSALSGQCGQSGQCGQSGQCGQCGQSGQCGQSGQRGQCHQSDAARLSFCTTLNMFNMRSASVVATNNTSPQLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC35</accession>
    <name>A0A0N1IC35_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Odorant-binding protein A10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IC35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF11">
        <property type="entry name" value="CHEMOSENSORY PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19049" checksum="2B08AA49ACDA0C01" modified="2015-12-09" version="1">MLNCVICKTVAPLSSNAQGGPTAPYPNAGPARRVQELDVLTQDPAHYTRGLELNDKAIIIANHYADPVPRCMRFCLLTLCLATLVYGAPSMTDAQLEQTLADRNTMQRHLKCALGEGPCDPVGVRLRTLAPLVLRGACPQCSAQETRQIRRTLAFVQRNYPWEWARIVRQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC54</accession>
    <name>A0A0N1IC54_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459939">
        <property type="protein sequence ID" value="KPJ19187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC54"/>
    <dbReference type="InParanoid" id="A0A0N1IC54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="15039" checksum="76BAB62E11DE9A26" modified="2015-12-09" version="1">MAEAELRAVFNALENHFPDAFRAAKIAAQNISRPASRSSNASMSGSEATSSYDSEMEVSASSPSDSNDGFTTVKNKKKRKKRPSSTASTSSSPVPLKAPKHIPLTEAGLTQPSATPIPSLMAIPVAPCTDVPVPSPQRPPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IC97</accession>
    <name>A0A0N1IC97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 161B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM161 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IC97"/>
    <dbReference type="FunCoup" id="A0A0N1IC97">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IC97"/>
    <dbReference type="InParanoid" id="A0A0N1IC97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019395">
        <property type="entry name" value="Transmembrane_161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624:SF6">
        <property type="entry name" value="EMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624">
        <property type="entry name" value="RE42071P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10268">
        <property type="entry name" value="Tmemb_161AB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="44890" checksum="BF91DF380C154145" modified="2015-12-09" version="1">MVSVIQKFSKYSFARWLLCSQGLYRYLYPDNNELKTLAGVPKDKPKGKKTGKSENGKPETFHVPRSLELQLETAPVTALDVVHLRFYAEYLWIVDFSLYTSIVYILSEIYTGIFPLKDEFNLSMVCAYLWCYLHCILLLFILKRKLLIIHNYIQSFDLCLIRLIIYYDDNKLKVLLLNINFAMPFVLVLLWVRPITRHYLTVRVFSGMTTPLMTSQAFDTLRLLLVVVTVVIKLMLMPKQLQAYLDMAQRKLDSQKKEAGRITNIELQKKIASVFYYLCVVALQYICPIILCLFLTLMYKTLGGYTWTGLIYDTEPEIRIPRSVPSALDVEGFEQYQMAWENLKMIFTVEVHRGLLGFASWWCCFSWFLTTSLGTMYQSYFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICT7</accession>
    <name>A0A0N1ICT7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460896">
        <property type="protein sequence ID" value="KPJ10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICT7"/>
    <dbReference type="InParanoid" id="A0A0N1ICT7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873865" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7861" checksum="A8FCE0562CC1C448" modified="2015-12-09" version="1">MKYIILQLLCFTGAWASPRLDPLVDSKRGLIRGLQATDGDYAMFLGIPYAMVNYTNPFGQDFNHPFVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDT6</accession>
    <name>A0A0N1IDT6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDT6"/>
    <dbReference type="FunCoup" id="A0A0N1IDT6">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDT6"/>
    <dbReference type="KEGG" id="pmac:106716350"/>
    <dbReference type="InParanoid" id="A0A0N1IDT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="401"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="637" mass="71309" checksum="36473CF60D17F004" modified="2015-12-09" version="1">MSTNKELKVVQYVPFKSFVHPSFWHSFTDIKLNIDKLEEAKKDIYGRYTYREDVGTVFEVDGTSFNKLPETEQYYINVKGTLINVNKLEDFKHSDKSILLNNSGEEVWLNVKSKAWITEPSRLINFFIYSYSDLKKYRYYYWFGFPCPNQPTVYINDEPVLITTIFNEQQLEQLNKGFNALDLTQRHYFTVTKNTNFVTVDCLSKILDAKKQVQSKNDINLSITYFAFTDPSCSTSPGWPMRLFIAALLEHCPDLYNTEINIIGLRYSANGSLQKSQVYNIKIPQTSETSGEGVGWVGWERNEKGALGPKLAVMSSSMDPIKLAESSSDLNMRLMKWRLVPDLDLDVMKRTKCLLLGAGTLGCHVARNLLNSKSIFAHIPMPGYPVGEDLMEEMYNNVKLVTDAIVEHDVIFLLLDSREARWLPTVIAALHGKIVINAALGFDSYLVMRHGVGLNAADAEGEGLRAATVPGGRLGCYFCNDVTAPGNTFAERTLDQQCTVTRPGVAAIAGALAVEMLAALLQHPLGVEAPAVYNPDNKEIDSGDDGVLGSIPHSIRGFLHSYQSVLPTCAKFKQCIACSDVVLNAYKDKGTEFLLKVFESGKHLERITGLEELHKSAELSDMLAFSDDEDQVNIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH99</accession>
    <name>A0A0N1IH99_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Photoreceptor-specific nuclear receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459680">
        <property type="protein sequence ID" value="KPJ20466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH99"/>
    <dbReference type="STRING" id="76193.A0A0N1IH99"/>
    <dbReference type="InParanoid" id="A0A0N1IH99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000022">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="373" mass="42262" checksum="3B936D27F362B187" modified="2015-12-09" version="1">MQLEDVLRYFDTPSLSLGSPPSSINQMFAFQNSSVLAKFSARHNRFVEQSSAVFSNQYDLGSFKIRLYRTRDNLGTPPPFDLKHSEIWIKKGRCERPLSLSESLGEYQQLWLYRTRDNLGTPPPFDLKHSEIWIKKGRCERPLSLSESLDDSIDVTNEEDSTSYSPPAITNYPQNCPPYRPLGVESSAETAARLLFMAVKWAKNLPSFASLAFRDQVILLEEAWSELFLLNAIQWCLPLDAACAALFGSEQTDQESGVNSATLRRLREVLARYRAVLVDPAEFACMKAIVLFKSETRGLKDPLQIENLQDQAQVMLMTHARTAHGAAPARFGRLLLLLPLLRLVSPQLLEREFFAKTIGHTPMEKVLADMYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHJ9</accession>
    <name>A0A0N1IHJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460535">
        <property type="protein sequence ID" value="KPJ14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHJ9"/>
    <dbReference type="STRING" id="76193.A0A0N1IHJ9"/>
    <dbReference type="InParanoid" id="A0A0N1IHJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="241" mass="24398" checksum="8C04C2635AEBC895" modified="2015-12-09" version="1">MFDAMFWAVDLLDIEMRSPAAIIIFMCAAGIASAGNLLHAPISYSAAPAVSSVSYSTHAAPITYAAAPAVNTYAASPVITKSLAPSVSYQSISTHSAPSLYAKTIATPAVATYGAPVLSKTISPAVSYSSVAHGPVYATSPLVAKTYAAPVIAKSYSPAVSYSSVSSHSAPVAYSAPLVTKTIATPAVTTYAAAPAYSTYSAAPAYSTYSAVPALKTAVTYSAAPAVSHVTYTGLGASYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHK1</accession>
    <name>A0A0N1IHK1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_03510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHK1"/>
    <dbReference type="STRING" id="76193.A0A0N1IHK1"/>
    <dbReference type="InParanoid" id="A0A0N1IHK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="229" mass="25561" checksum="1197A6CA0ABA4BB0" modified="2015-12-09" version="1">MAHSGGVLSSDISRRNPQDEYELVQRIGSGTYGDVYKVHDATPFRFNEQDTAIEHFGRLLSAAGYQHHGTERLYSGVDGREMQADIFFGVIHYQRLRHMVSDKWQVRTTGAVDTLTRQPVKGRRRGGGVRLGEMERDALISHGAAFLLQDRLFDCSDKSEAVMCTKCGTLLGPVLRKGDSNNDTCRLCGQGKFVSVYIPYIFKFFVTQLAAVNINVRINCNGSFAIKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II71</accession>
    <name>A0A0N1II71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044508">
        <property type="protein sequence ID" value="KPJ21423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II71"/>
    <dbReference type="InParanoid" id="A0A0N1II71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="12030" checksum="DE04951D80C64DAB" modified="2015-12-09" version="1">MMDDLTISLLEDVKRNVTRRNHFDDCLDDTEKYRMELLKDTKVKKNNASSVIYVKPCENNDPSQPCGTKYNFYKRHVSTPFLCSEKIKNPVIVKEEDRIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIA1</accession>
    <name>A0A0N1IIA1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01051844">
        <property type="protein sequence ID" value="KPJ21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIA1"/>
    <dbReference type="InParanoid" id="A0A0N1IIA1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7587" checksum="BB57A22CD44CAE1C" modified="2015-12-09" version="1">MTCATSRANYTSLRAQASATRIATTTHKSVVSYSLALRPRCRRPSELILQYLYSWMYDIKCHKTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IK10</accession>
    <name>A0A0N1IK10_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IK10"/>
    <dbReference type="FunCoup" id="A0A0N1IK10">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106708407"/>
    <dbReference type="InParanoid" id="A0A0N1IK10"/>
    <dbReference type="OMA" id="GRKHKFG"/>
    <dbReference type="OrthoDB" id="6627399at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF9">
        <property type="entry name" value="OSIRIS 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874005" description="Osiris 16" evidence="2">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27149" checksum="505A4E4C9995536A" modified="2015-12-09" version="1">MYITIYFCSLIVTYTLALPNPEVRDGLQNNIEPESSARVLGKDCSGGIFSPTCLKIEAISILEKLSSKEELQLLPGVSVVKEEKENGSKAEEFAAELARSLPSKPDERLDKYLLYRLGNYLDTHSVKLRLLDDGASEDARALMGEGRGKGGLGGGKKGGMGGLLAAALMMKGTLMSIGLGGLAMLAGKALMTALMSLLLSAIIGLKSLTSGGKSTTYEIVSKPVYSHSHSHSTAHEDVGGYGHSGYGRNLKVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INF4</accession>
    <name>A0A0N1INF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Spondin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INF4"/>
    <dbReference type="InParanoid" id="A0A0N1INF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000120">
        <property type="entry name" value="Thrombospondin, type I, domain-containing 7Ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF15">
        <property type="entry name" value="SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874054" evidence="9">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="422" mass="47951" checksum="D9C92046988133B1" modified="2015-12-09" version="1">MARLQMAAIFLFFSICYACDVDMAVYKVTVRMLWSEQTFPKDYPMQRPKAQWSPVFGQSHNKSYTLFRVGEVAKSSVRNFAQYGKLDTMILEGEEDPRVYDQFSTPALGSGTGETENLVFVDTEHSEISMISKIIPSPDWFIGVDSLNLCVDSSWIDEIMLDLEPLDAGAASGLTFTAPRWENSPPEVVSKHKPRQPNHPASGFYYPNKKELPPIAKVQFTKVKEYSSKEVNDLARKEILSNLHLKDKLKGLPKKKSSKSYQTTELNQEVTTKNNFDQLVELEEEPFGTPRPNVPDNKVEIVTNAPTTTIKMDEEFDSDLKNMDDVVLAVANGNRLGLGKRLPRHFRSRLHHAVNRIQPDDCLVSEWGSWTPCSATCGFGDQFRTRRVIREKRGDGRNCPTLTDRKHCGNINSCAHIDYFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP19</accession>
    <name>A0A0N1IP19_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP19"/>
    <dbReference type="InParanoid" id="A0A0N1IP19"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="14452" checksum="D3A5B014D3581A36" modified="2015-12-09" version="1">MTTGKVHDVNGTESWFYIRSARGGLHLVAGGHIFYEDGGSHPRRVTWRCARSYQKAERCQVALCLRDGRLVYFRGAHNHPRTYNPAKHESRRFEVDPRGKYKIMVTAPRTFAMAAPPPPPGPHAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP30</accession>
    <name>A0A0N1IP30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZIP11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460810">
        <property type="protein sequence ID" value="KPJ12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP30"/>
    <dbReference type="STRING" id="76193.A0A0N1IP30"/>
    <dbReference type="InParanoid" id="A0A0N1IP30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="16312" checksum="616B9EB73AD46F52" modified="2015-12-09" version="1">MIPGYGAVTQALLGTLFTWGLTAVGAGCVFFIRGKHRKLLDVSLGFAAGVMTAASYWSLLEPAIEMCKTSGTYGEEGQYAFVPVAAGFLFGAVFVFGTDKFLDYLGINSTNMMITHVVVIFPFPPISYKKGMGRGASSATYTFPLKGLEPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFY7</accession>
    <name>A0A0N1PFY7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotriesterase-related protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Parathion hydrolase-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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    </comment>
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        <location>
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        <ligand>
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            <label>1</label>
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        <ligand>
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            <label>1</label>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
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                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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</entry>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
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                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
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                <person name="Chen Y."/>
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            <end position="48"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="218" mass="24361" checksum="FE1FCBBE263DADC2" modified="2015-12-09" version="1">MSMYRFVKEGSSKRLFVQGTLESDDNKPLKSSLKKPSPSPVGSPITTSLNLASVPRSLREGLTRNETVYDGNYPGMERSSSYRSGSFREESYNGRIVHDGNQTHFEYDAGESALAVPLSAGGRGISELQAIHTNKRMSTEVLGSSLESTKISKKDDSGQRRITTRIVRKVTTLTRGEEKASTEDIARGGREVHRSSEHYRHMEMERHPRKVKVPFITN</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
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                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH78"/>
    <dbReference type="FunCoup" id="A0A0N1PH78">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH78"/>
    <dbReference type="InParanoid" id="A0A0N1PH78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000064">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000037">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="237"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ10203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="473" mass="53558" checksum="F2356794423397B0" modified="2015-12-09" version="1">MGPLWNALRLISPRTLSNNGLKRQEWNDYNLRWNDSEYGGVKDLRITPNKLWKPDVLIADEGFDGTYQTNVVVRSNGSCLYVPPGIFKSTCKIDITWFPFDDQHCDMKFGSWTYDGNQLDLVLKDESGGDLSDFITNGEWYLIGMPGKKNTITYACCPEPYVDVTFTIMIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGVTILLSQTVFSLLVGHVITKTSEAIPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPQWIKTVFLQWLPWILRMSRPGKKITRKTIMMTNRMRELELKERSSKSLLANVLDIDDDFRHAPPPPNSTASTGNLGPGCSIFRTDFRRSFVRPSTMEDVGGLGSHHRELHLILRELQFITARMKKADEEAELISDWKFAAMVVDRFCLFVFTLFTIIATVAVLLSAPHIIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIA9</accession>
    <name>A0A0N1PIA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Origin recognition complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIA9"/>
    <dbReference type="FunCoup" id="A0A0N1PIA9">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIA9"/>
    <dbReference type="KEGG" id="pmac:106715129"/>
    <dbReference type="InParanoid" id="A0A0N1PIA9"/>
    <dbReference type="OrthoDB" id="5552484at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11583">
        <property type="entry name" value="Orc6_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="8">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="285" mass="32810" checksum="8CAF7893D5CCCB8A" modified="2015-12-09" version="1">MTTYNKTFRLLASKLSLQDEENVLRKAAELERLLQTKTIAGSNITDNSKIVICLDLAANMYGVDLDLKTAVKYSGLKQPTYLNSRKILENLLELNDDKMSISFLCISLQCTEVQALAEDILEEYKKKSKMDIDLNLPQYVCMAVYHACRINKVKITKSKVIEKSRLKPSQWSKLDAEWSKFVNDNFASVKKTKGRPRKEVIEDANNGIENNTSIKEEPMDQIEPYDVWKKRILEEAYKELIAMEEVEKAQNVMPIRRSPRKTPQKTSPYKTPIKGKGIRLLFPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PII0</accession>
    <name>A0A0N1PII0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01000510">
        <property type="protein sequence ID" value="KPJ20836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PII0"/>
    <dbReference type="STRING" id="76193.A0A0N1PII0"/>
    <dbReference type="InParanoid" id="A0A0N1PII0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="392" mass="45919" checksum="2C02EB85F2DE6F81" modified="2015-12-09" version="1">MDYPEWYSEKKYNQGRRFYWDNCFSLTSSMLLGLVAVFAVPSILRVLISSRRSSSQYTAYRRYLSTLLHTVSWFENDLKPGSISWRSIYTVRCRHARADVAAKMKGIGSVSQRDMALTQFGFIGFSILKPDKFSIRPMQSDDWESYVHFWRVIGSMIGLQDRYNICRKNYQETRQVCQLLLERVFTPSLDHVPEYFEHMARVMLEGMWSVNPTVNTSALLYWTRHLADVPGYVYTEKERADFQDKLREQLKGKSEDIGVDSTVFTSRPAIEGINERPPRLLYLRDYDTIETIPEYKNLPFAAKYKLAVSSILYAFYSTYIGKLYLNLNFLFSLLLMKYFPYLAFFRFGIKASLVNIFVEDPVDNTEPKPNAEYNKPPPELPWYRATLSVLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJH2</accession>
    <name>A0A0N1PJH2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_04119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJH2"/>
    <dbReference type="FunCoup" id="A0A0N1PJH2">
        <property type="interactions" value="2086"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJH2"/>
    <dbReference type="InParanoid" id="A0A0N1PJH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="227"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="591"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ19958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="694" mass="78692" checksum="A1D0616328FE21EC" modified="2015-12-09" version="1">MSESTSPSVLSYLRQYRFQRKPNAPGSSGTVTIAGPSSNSQSLIRMPAPVANRNGPIVYKRIRILDSDSDDSASPAKKPATSQVELTTAVKERRFRNMLEMFPEISPMLIKNTLVKKGWNEERTRDELLKYDPETDDKGTSSNFISPRPSFSGNISRPNGNMGIVRVTSGGPITIVKKALASKGGRARRGSSGSEDEDYGVRKGKDDKVYDSLKLAPYQLVGLNWLAVLHKQGVSGILADEMGLGKTVQVIAFLAHLKETGQARGTHLIVVPASTLDNWSGELARWCPSLRVSKYYGNPEERRQMRVEYARGLDNIDVVLTTYTMVSSCPEERKMFRITSMHYVIYDEAHMLKNMSTQRYDNLLRIKSKHRLLLTGTPLQNNLLELMSLLCFVMPHMFSGKTDDLKSLFQKNAKVKTAKKTNGTTNPEDDVPAFEESQITQAKRIMKPFVLRRLKRDVLQDLPKKTNHTELCPLSGRQEMLYKNLIAAFSAKDGTIHATTEQSGLSMMMDMRKLANHPLLLRYHYTEPVLRKIAARLVREHGYKEKNEQYAYEDLLCMSDFQIHQLTLLYPSIRSHSVPDHLILDSGKFQKLDEMLPRLKAEGHRVLVFSQFTMMLDILEPYLKLRRYRYLRLDGSTAVTDRQELIDQYNAEDIFVFLLSTRAGGLGINLTAADTVIIHDIDFNPYNDKQAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK11</accession>
    <name>A0A0N1PK11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK11"/>
    <dbReference type="InParanoid" id="A0A0N1PK11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="499" mass="57604" checksum="812968D77CE24B14" modified="2015-12-09" version="1">MEKERQLSEKPNGLESLKGFQEDPPEEFESPRGKRSPQELDNTEIRYEFESRLQEDPPEELESLRGKRSPHRLQEDPPEEFESRGKRSSQRLQEDPPEEFESRGKRSPQRLQEDPPEEFESRGKRSPQRLQEDPPEEFESRGKRSPQRLQEDPPLKICNKPLYKICNKLVKFVPQSFQEDPPEELESSRGKRSVQIPAGAGLIRMARRSNGGGRRRNGVGLLDNTGLRSNGLQEDPPEELGSRRGRRSPQGLLDNTELRSNGLQEDPPEELGSRRGRRSPQAPGVAGLTRSQEWFASPLEGVQEVNEISGEIEPAADGVNVVKRESPYIERAAPRYEDESMLEAQGMCVEVEGLEVCLPREKRRKKHRLSGPKMDKNKKRKPEFQEIGEKSSLKMSTSMHFLFMLLIFGFFAMFNTSQVSHKWLKNLKKPRFTNRGVGTRIFWPKRSIDQRDYMTHGHVYKDGLPDRYTTPGSGGWYYFFLNVNKDVQRGKQNLEEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL80</accession>
    <name>A0A194QL80_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL80"/>
    <dbReference type="FunCoup" id="A0A194QL80">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="ESTHER" id="papma-a0a194ql80">
        <property type="family name" value="SERHL"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719840"/>
    <dbReference type="InParanoid" id="A0A194QL80"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="35614" checksum="2E37A45F8DA4B626" modified="2016-10-05" version="1">MNQDKSNGHKIEPDLPAGVQVEEIEIPVPWGHVAGRWWGPRDKQPLIAIHGWQDNAGTWDNLIPLLPTSTSVLCLDLPGHGLSSHYPTGMLYYIFWDGIALLRRIVKHFKWSKISLMGHSLGGALSFMYAASFPDDVERIICIDIASPAVRVPENMVKATGWSVDKILEYETLSEDKIPCYDYEEMIDIVVDAYKGSVSRENCKVLMKRGMAPTPAHLKKKGYHFKRDPRLKVSGLAMMSLETALAYATKVKCKVLNIRAIPGQNWERLDYYMAVVDKLKESADVTYIEVEGTHHVQLNSPENIVNIVEDFLEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM12</accession>
    <name>A0A194QM12_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM12"/>
    <dbReference type="KEGG" id="pmac:106720196"/>
    <dbReference type="InParanoid" id="A0A194QM12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF236">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ05995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="640" mass="71245" checksum="B76CA2C1F9381B52" modified="2016-10-05" version="1">MAGGDYTMNQSEANGKVPAQVTTSTGTPEKAAWGRPLEFILACLGYAVGLGNVWRFPYLAYRNGGGAFLIPFLLMMILIGLPLFFLELYIGQYTSLGPLKAFEAIAPFFSGLGYCTLVVISLISIYYMIIVAWTLFYTIVSIAGNLDWGSCENEFNTDFCYSGFYDAQCRVNNTGDSTDLTYYLRRCISIGEICMSTGFEPYDGRYCLNGTETIPWYSNVKRTIAAEEYYTQRVLGRGDATWENWGTIQWHLVGCLALAWFVAFLCVIKGVQSAGKVVYFTALFPYVMLTALLIRGVTLEGARDGIVFYLTPDWSTLLDARVWGDAASQIFYSFGVACGSLITLASYNGFYNNCHFDTVFVCFANFLTSVYAGFAIFSVLGFQAELMGVQIDDVAEQGPGLAFVAYPEALLQMPIPQLWSILFFLMLFILGLGSQFAGIEAINTAIVDQWPQFRKRYWMVTATTCFCCFILGIPMCFSGGVYLFTLLEWNTASWAILLIGLAESAAVAWSYGINRAMNDLAAMNMKLNAVLRFYWKTTWAVTLPVASIAVVAFIFSDWKAPSYADYEFPLFADILGWITATSTIILFPVGVGWAFYKGYRGKQLFTPTEDWKPSSRSLCNPPNDTSTDTNQTDYDNVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMC3</accession>
    <name>A0A194QMC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMC3"/>
    <dbReference type="InParanoid" id="A0A194QMC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="157" mass="17061" checksum="ECBEE14C77B32A23" modified="2016-10-05" version="1">MRKCKKTREKSGSVGASGCAGGEREMQRGAQGESESGARADAVPGSVRCVASRRARTKGSIYKVFERATCSVQLGARVARRARRRGRAVSATYRTSARPAPLPGLPPAGIRSPRAGDGPSGRTMTPQRVHRSRFEDDLYFTPRPLPHRWWGPIFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNG9</accession>
    <name>A0A194QNG9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_14259</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNG9"/>
    <dbReference type="InParanoid" id="A0A194QNG9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="16">
        <location>
            <begin position="60"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1394"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ06520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1466" mass="168164" checksum="1598876A8B819CAF" modified="2016-10-05" version="1">MATTPGFKDLPDDSDQSDSEFQPLYDDTDELDQRTAQETKGWNLFREIPVKKESGSMASTEWIDISMKVFKVLAYIFTFAAVLGSAVIAKGTLLFITSQLKKERHVSHCNKALALDKQFLAVLPLEERVTWLWAVLIVFGVPELGMFVRSVRICFFKTARKPSRLQFIIAFLIETLHAAGVAILILIILPELDVVKGAMLLNSLCFVPGLLNALTRDSTEIIFYYLCELKLALKKTRYYTQRILSLWKIFVFMVCIIISLHVQNDNPFAIFTSISDAFAPRNYSVYELRIIFEDAYDGNLEFDLSEAAFVLPVSWTSPLWVALIQVAAAYFCFASAKFACKILIQNVSFTFALSLVGPVLVNLLIVFCAMRNADPCAFHGTIPDYLFFEIPPVYFLKEYLGNEMVWIWLLWLASQAWITVHTWMPRCERLAATDKLFSKPWYLGPLIDQSLLLNRTKDDENDIAIEDLRELQDEDDRSHASSEQVAKDIKPSDSITRIYVCATMWHETKDEMIEFLKSIFRLDEDQSARRVAQKYLGIVDPDYYELECHIFMDDAFEVSDHSAEDSQVNRFVKCLVDTIDEAASEVHLTNVRLRPPKKFPTPYGGKLVWVLPGKNKMICHLKDKSKIRHRKRWSQVMYMYYFLGHRLMDLPLSVDRKEVIAENTYLLALDGDIDFKPCAVTLLIDLMKKDKNLGAACGRIHPVGSGFMAWYQMFEYAIGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTLTSNEARHYVQYDQGEDRWLCTLLLQRGYRVEYSAASDAYTHCPERFDEFFNQRRRWVPSTIANILDLLADSKRTVEVNDNISTLYIVYQILLMMGTILGPGTIFLMMVGAMNAITGMSIMNSLLLNLIPVLIYLVVCMTCKSEIQLMLANAITCVYAMIMMMVIVGIALQIVEDGWLAPSSIFTIITFGIFFVTAALHPQEIICLLYLGVYYITIPSMYMLLIIYSLCNLNNVSWGTREVAQKKTLKELEMEKKAAEEAKKKMDTQGMMKWFGNKSEENSGSLEFSVAGLFKCMCCTNPKDYKEDLHLLQIANSLEKLEKRLESLGAPPEMETAPRRRSSMPLRGDTLSLLPEYADSEGSADIPREERDDLINPYWIEDPNLQKGEVDFLTTAETEFWKDLIDAYLRPIDENKEEQERIKTDLKNLRDTMVFAFVMLNALFVLVIFLLQLNQSQLHFKWPFGQKIGIMYDEEMNLVYLEREYLMLEPIGSLFLIFFGTVMVIQFVAMLFHRLGTLTHLLSTVQLNWYFTKRADEMTEQAIIEKQAIEIAKDLQKLNVDDLERRGVDQASVARRKTLHNLERARDNKHSVINLDANFKRRLTLLQNADPDMIARMSSLRGSVSARRATLRALQARRESLTAERRRSQLQRDSTTYLYDEPKTTLSDLAGRSSMSGAYVNKGYEPALDSEDEGSPAPRRSTVRFRDNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP23</accession>
    <name>A0A194QP23_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General transcription factor 3C polypeptide 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP23"/>
    <dbReference type="FunCoup" id="A0A194QP23">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QP23"/>
    <dbReference type="InParanoid" id="A0A194QP23"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="17936" checksum="9BC96FA13B832E10" modified="2016-10-05" version="1">MTTSASDSEEEVLVYAEFKDTVNIEKYKNIHVLGIDRKNPVIQLDDTFFTGSFENPLGTYLFFEEDQTPHCDDPLFDKLPEKNLKYLYKTTKLLSMEHAYVTSKEGSDIENKLQQSSESETIEPVTFENLEEALETFKKDKQEYDDSELKPVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPC3</accession>
    <name>A0A194QPC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fork head domain transcription factor slp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPC3"/>
    <dbReference type="STRING" id="76193.A0A194QPC3"/>
    <dbReference type="KEGG" id="pmac:106719457"/>
    <dbReference type="InParanoid" id="A0A194QPC3"/>
    <dbReference type="OrthoDB" id="6230630at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="313" mass="34070" checksum="3FCB6E56C1D31527" modified="2016-10-05" version="1">MVKFEGDFSINAILMNREASKSPPSPTTSAASPAGAALSEAELSDSELDVTGTEPVDCSKPKPDVADKKHEKPAYSYNALIMMAIRNSPEKRLTLNGIYEYIMTNFPYYRENRQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDASAEDVFIGGTTGKLRRRSALNGRARLACFKRPLFPGAALPPAYPPAAYSQLVGLYSQLLYQRYAPMQMKASPVAPGALHPALRGADAMGYSALPYSPALYASERLTAPFLPPSPPALRSPPASGASSPDLPAGHLAHPAHLTPQSHHALAPHIYKPVPVLTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPI8</accession>
    <name>A0A194QPI8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_11389</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPI8"/>
    <dbReference type="FunCoup" id="A0A194QPI8">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPI8"/>
    <dbReference type="InParanoid" id="A0A194QPI8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="40323" checksum="B025F719EA3FE6C7" modified="2016-10-05" version="1">MNRCRTCLGSDKEMRHVHTKISISGESVLLSDILLNFYSYKVTEGALPENICINCVHQLILTYSFKILIESSAKTLAESNNQIVPDVPKHHKKKKLLKIRKSTVNSECQSNNLYCVECKMMFNSAKVLHEHCLKNHPVKNVIGRECEYCNEKFEDFRSLVLHRKLHLKPYLCENCWEGFYNVEDLQTHFCQPNTNNKDKNKSDKDLRQCDQCGKSYPPSYIRIHMLTHSNDRPYSCKYCPKRFKVPGGLHSHILWNHKRVRNHKCEVCNATFISSSSRSSHIRKSHLKEKKYGCESCGKRFFSKSELQRHSLTHTGVKNFHCHLCVKSYQTRYGLNVHLKSHTSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPS5</accession>
    <name>A0A194QPS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPS5"/>
    <dbReference type="STRING" id="76193.A0A194QPS5"/>
    <dbReference type="InParanoid" id="A0A194QPS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="45" mass="5578" checksum="C5E28FCAE9B4834A" modified="2016-10-05" version="1">MREQSDAPKKRRNRFITCEICKYRAFRKPGIKREFMTRFPLDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPZ5</accession>
    <name>A0A194QPZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain-containing protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPZ5"/>
    <dbReference type="STRING" id="76193.A0A194QPZ5"/>
    <dbReference type="InParanoid" id="A0A194QPZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF34">
        <property type="entry name" value="LD40565P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="178" mass="19398" checksum="A7D43F93BF598AB3" modified="2016-10-05" version="1">MAALSSRVAGACCAASVERAGLPGLLRDLLRLAEDQDSADVVFILGTAEEKVYAHRIILFARCKSFQNTKRGEICRIPGCTVSPSVGTQPTPIRMPHVQPETFRLFIQYVYTGKLLLQDSGVFEMMTLAADLGVEDLRAACEDHVTSTLSVESACTLLAAAMEIQDRPARQSSRIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ12</accession>
    <name>A0A194QQ12_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ12"/>
    <dbReference type="InParanoid" id="A0A194QQ12"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8538" checksum="DB17A1965DE05F50" modified="2016-10-05" version="1">MTGRRKKRTKRSSSGETPVEDLILTGKRSRKTIQRETWSGSESEEEDPYGTDDSDDWQPPSNVSETQDYSQASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQK4</accession>
    <name>A0A194QQK4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrosomal protein of 135 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQK4"/>
    <dbReference type="FunCoup" id="A0A194QQK4">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQK4"/>
    <dbReference type="KEGG" id="pmac:106719221"/>
    <dbReference type="InParanoid" id="A0A194QQK4"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="235"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="476"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="666"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="767"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="886"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1093" mass="127056" checksum="183C6AB8069408AF" modified="2016-10-05" version="1">MSEGYFNLKQKLEDLGYNYSLPIEAVPLVECIVADLLQTTRSLQHYMDLSKDALIQRDSLMMEAEPYKCDNAKLIRENNSLHKEILTLKEENMRLSKESKRKIKCMTDEIMKKDILISKLQHDIRDLSLRGLCAGTQSSRNKSRRKDDESTAVSKICICNSQSNNDLGKDTLELSKTIQLLKDKNDTLEDEITLLKSKVEQRDDEILRLNMMLEGGRPLTAINKDFYVNNPDHTEQAIFQQLKKIQIENDALKKEIHNGLGKQHEAMLRALSLADKNRNLEEELQKVDKLALQVEEECNKKLSSLTNEVNYLQTRLESLRFKNSELQRELSEFHRKDKSPQSCYTQESLKLALKERDILQKEIKDLIDINKNLQDKIGSLSQFNKNYQDKISMDNLHNNNGSKCLQKEELQKLLHEERVKYEKYMIDIQDKLSEALNVFNKHVHSGFGTNSQRDISPDNTFIKELHNRLCESEQKILMLKQENSELRQNAVQQEDNNRENLKDVIKQLNMENTQLTKENISLCQQLSQHRMMNSVQTNPDESNLKELSKLRDKNDCLTRELNYFKKDQQEYKLRYKEAVDLVEKLKRDLTHKQKQIEQLEEENYSYKMTNRTGKASAEQLRDECNFLREQIKTMQTDVIKEKTIASQIKNIQIETERNSSEVQNELLNVQKKLSLSKDQISSLEKKCKELQSEINSLQIDKTNLIENIKSIDRERDKLVIELDNKTERVSNLDDKVKSQAYEISKLDKENGDLKRKLNIQISTEHKLADYESQIMFLNGEISRLTQQNDTAVMENKRLQNNLGDANGALKLTKLELEKTKKEVDSLKQQLQHYVAEVRRIEELLSQKEAERSDMLEQFASLSVEANILENTNHSLESESASKSMQLQSYVNRIQNLESKLIDKENIIDSQSAQIAAMTCKVNALENEIKLISDEKKILEQNISYMKQMCNHMQIEQSQKNLDLKDTDSELKLYENKIKCLSNTKAKLQVENEEMKNKLSTTEKLLSNARREIIELKLALQDATSETKSLKDCVTRLSREPDIHEHTLINEDIDLPHSLGDTIHEVSNEDDDSIIHGDHMLHKTYSKYSHGSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQW4</accession>
    <name>A0A194QQW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein C9orf46-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQW4"/>
    <dbReference type="FunCoup" id="A0A194QQW4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQW4"/>
    <dbReference type="KEGG" id="pmac:106718746"/>
    <dbReference type="InParanoid" id="A0A194QQW4"/>
    <dbReference type="OrthoDB" id="10256697at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="18259" checksum="160C2DD601FAA587" modified="2016-10-05" version="1">MGGFISINLEENYKKNEKFLQSLNEIAMERQIQLQFQMQERQRALQIARSRDIFLWLSAFSITAATGLLTGFRRTKRIYLLAPLVPLTFLNLYHLDLAYGNKLHRIRMEAEHIMSHESDFLELPCGLPSPSSVDQGRMDAEEKKKIHPPYLKLLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR43</accession>
    <name>A0A194QR43_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fidgetin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR43"/>
    <dbReference type="STRING" id="76193.A0A194QR43"/>
    <dbReference type="KEGG" id="pmac:106718407"/>
    <dbReference type="InParanoid" id="A0A194QR43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="314"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="7">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="6">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="538" mass="60734" checksum="161303763B8B72B4" modified="2016-10-05" version="1">MYNSQENNDSDPIPEEKSIKCDGNDFNTQLAIYQQSLKTSSNLASKIILDTVWETKQDCFSDERMNKILNSAQSLIQYPVAQNTRKWRSSLSKITDPVKMFEKSIYQCEKCSTSQNYNGFEKFIRNECKCEICLLENSNCKPELDTNRPTNNVEQNTREKISSNKQKNIVKSNMPSKPAINKPNISHYNAFINNTGDLKTDINTKTNWEYGTNENIRPQNYLDKEEEENKAHKSNVAKITFKTARETFLASNPSAKRVLGVSRKTQGKFVSPMISAQEKQEKSEAIASDDRLKHIDSKMVELIESEIIDKGTPVGKCIAAQCRATFFSISASSLTSKWLGDGEKMVRALFAVAACHQPAVIFIDEIDSLLTQRCDSEHEATRRIKTEFLVQFDGAATGEDDRLLVVGATNRPQELDEAARRRLVKRLYIPLPDANAREQIITNLLSTENNDLTRQDMAEIAVLTDGYSGADMKSLCSEAAMGPIRSVPLSQIINIDRDKVRPVSVQDFKNALQRVRPSVSQDDLGQYIKWNNTYGQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR47</accession>
    <name>A0A194QR47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 6B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase subunit VIb isoform 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
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</entry>
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    <accession>A0A194QR49</accession>
    <name>A0A194QR49_PAPMA</name>
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        </recommendedName>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
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                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
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            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
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        <location>
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            <end position="466"/>
        </location>
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            <end position="157"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="494" mass="55829" checksum="52366FCE50F740A0" modified="2016-10-05" version="1">MHVDRNWFVTSRDPVGTVVTRVQPESAGGARVRYGLETSGPPAPFTIDSETGIVTVNDTLIDKENQSYSLWVTADDGSIPQRLEVLAMVTDRSGQRPKLPRPPFDLPNYPNIPDLSSLHQLTKFTRTTQRTTKATSESNEEITVPETTPFTTKKPDDKIEKTTDKVEKLGQEENKNNTKIQETPIGSDVSLTIIPLIAIGGLVVIVAAVIIFVCKKNGSNGSKSKKDDMSKDSSGIVLQDASINMWDRPRAYSNRYESWDNGHLQEPTLVIMEYVSLGKLQQFLRESRAGRHYGNTHAGSLFLTSRDLTHFAFQVARGMDFLSCKGIIHRDLAARNVLITEERTCKVADFGLARDVAGTHVYERKSDGRLPIRWMAPESLYDDIFSVKSDIWSFGVLLWEIVTLGSTPYPGLSAGDVMRKVRDGHRLEKPEHCRRELYNIMYYCWEAEPTSRPDFKEVVAMLERLLCTEMDYIELERFPDHSYYNVQNLEGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR54</accession>
    <name>A0A194QR54_PAPMA</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name type="scientific">Papilio machaon</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
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            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR54"/>
    <dbReference type="FunCoup" id="A0A194QR54">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR54"/>
    <dbReference type="GeneID" id="106718468"/>
    <dbReference type="KEGG" id="pmac:106718468"/>
    <dbReference type="CTD" id="219541"/>
    <dbReference type="InParanoid" id="A0A194QR54"/>
    <dbReference type="OMA" id="QRFCGSK"/>
    <dbReference type="OrthoDB" id="10044050at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="26366" checksum="3BBFDB9BAF3D6A69" modified="2016-10-05" version="1">MMSDQFRKVEPYSPKSSPRGARSPVVSRQDSSGTLKTTISLGKNPAILHSGPFYLMKEPPGECELTGATNLMAYYGLEHSYSKFNGKKLKESLSSFLPNLPGIVDGPGQEDNSTLGSVIAKRPIGGKELLPLSSAQLAGFRLHPGPLPEQYRYVSATPPKRHKSKHKKHKHKDGAPPGQDTPLQDSSNPDTYEKKHKKQKRHDDDKERKKRKKEKKRKKQKHSPEHGGLTPSQHPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRI2</accession>
    <name>A0A194QRI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homeodomain transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRI2"/>
    <dbReference type="STRING" id="76193.A0A194QRI2"/>
    <dbReference type="InParanoid" id="A0A194QRI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF6">
        <property type="entry name" value="PROTEIN PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="308" mass="34647" checksum="6AB49EB810D8A6A7" modified="2016-10-05" version="1">MWERGWTLRAELSAVDISWCVVARAERAMAAHGALWPALLMAALLALVAPATRLLQVAIEQDTRGEEELQALSLLSYIPSLFHNRADWPRSLFSGAFGDTVWEVSTSMISCVLRFSLSALVFFLLAVAERALKQRFLYAKLFSHLTSARRARKSELPHFRLNTVRNIKTWLSTRSYLRDSVTLECGWLLEAMVWSCGLGIHLLRLLTLGSNVNRKYRGCLSAILTEQINLHLAMEQRPDSKEQLTVANNVLKLAADLLKELDAPFKISGICANHYLYTIIKVVILSALSGVLSEMLGFKLKLHKIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRQ2</accession>
    <name>A0A194QRQ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein I'm not dead yet</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRQ2"/>
    <dbReference type="STRING" id="76193.A0A194QRQ2"/>
    <dbReference type="InParanoid" id="A0A194QRQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="306" mass="34094" checksum="05A8345D984DA52F" modified="2016-10-05" version="1">MTSCLFNKQKLVLNVLYSAGGLGTIIGTATNLVMKGLLVKSFPLVPEYLSFPQFSAFSIPMMICLEATMLLSLCVVFLGWLRPKSTAAKRSYVTPQGQAAAKAVVDASWKELGSITFWEYMVILLFGGSMVLFFCRSPQMFPGWGDILEDIFDRPHKFIKDSALACLVGFLMFVSPSNLSFFKNFTVKYYEQLPKKPVSSVLDWKKMDATLPYSFMFLLGKLAKQIKLNPLWYNLAGGLSASYCFMMPVGTPGNLVVQSAASIATTKMMIAGAGPTVFTIFLTWFFLYFWAPVIWPDLTTMPSWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS62</accession>
    <name>A0A194QS62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS62"/>
    <dbReference type="STRING" id="76193.A0A194QS62"/>
    <dbReference type="InParanoid" id="A0A194QS62"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="124" mass="13443" checksum="3D8C4E3415372C76" modified="2016-10-05" version="1">MGESSIEEVDYEYGAGAKILLALDALGAYRDLCGRLTRGLHGERAAAAAAQAHSAAASLLRKRHRFALVCCLEESRVARAYALAALESLQEPLRTHGVAHSRIATLWADLHSTLTYTHTNNKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS72</accession>
    <name>A0A194QS72_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS72"/>
    <dbReference type="FunCoup" id="A0A194QS72">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QS72"/>
    <dbReference type="InParanoid" id="A0A194QS72"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="284" mass="32558" checksum="0CA07F31716807CB" modified="2016-10-05" version="1">MSVWRTKLRWETGYSADSVEWCPVPPYNNVLVCGTYQLDKKDEGQQDKKQTRRGRIYLFIVNDDTQELFPAQSIDTAGILDQKWCNHTIGGYPILGVVTSEGKIQLYKLYDTDGLQLKLWIEVSIGQDVLALSLDWSRGDDCIFKAYDLRAPNAVVSNRRHEAGVTAVRSDVVTEHRLLTGSYDEKVRLWDARNLKCCITDENVNGGVWRLKWHPYNNRVVLAACMYGGFRLLRVDEEISVIGEYLEHESIAYGADWKFEKESLMVATCSFYDCKIHVSEIVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTA5</accession>
    <name>A0A194QTA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gem-associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTA5"/>
    <dbReference type="STRING" id="76193.A0A194QTA5"/>
    <dbReference type="KEGG" id="pmac:106718167"/>
    <dbReference type="InParanoid" id="A0A194QTA5"/>
    <dbReference type="OMA" id="NPMVAMQ"/>
    <dbReference type="OrthoDB" id="77463at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046857">
        <property type="entry name" value="Gemin6_Sm-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06372">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="160" mass="18186" checksum="F7707EC4F014FA65" modified="2016-10-05" version="1">MDEKSVQNYSTLREDPEVLLQFVNKYCTVELIKNTSFSGFVHSIDPISKSIILAVPFENSFQITLLPGHAITNLFESNQEKLTSPFQKLKDEISNNDIAARKSKVMDWFKVNLLTVTELNDNIVFGNVSILPPYSVTDICTDNPMVAMQVRKIIERMPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU39</accession>
    <name>A0A194QU39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU39"/>
    <dbReference type="InParanoid" id="A0A194QU39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="15571" checksum="47F586DCA956B76F" modified="2016-10-05" version="1">MEAGDVGFNPRLPNHHRRVRCRVPPLTLPGRGGAGYASTPPRPHHTHPATRAAGGRINQYPPAPPAAPPPGQLRGGPTKSASGSPAPPPGQLRGGPTKSASGSRLRVGRPCTLDQSSPAQDDRSYTLGRPWFLLASPWKAATVTRAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUF4</accession>
    <name>A0A194QUF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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            <taxon>Ditrysia</taxon>
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            <taxon>Papilio</taxon>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
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                <person name="Feng Y."/>
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                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
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                <person name="Wang W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
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    </evidence>
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    <sequence length="112" mass="12731" checksum="EB73DD385577D3F4" modified="2016-10-05" version="1">MSLIHRIDKLRKIKVVTTLLLIILVNVSCADLLTTKSYVGLIFPVLAPPKNSRARVTETAKDYPVLFLLANKNNNYKDAPRMGEQSEPIYVERLEERINPRHAMLGKRTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVQ7</accession>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
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                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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    </evidence>
    <sequence length="128" mass="14788" checksum="F68E8D0BF9AB231C" modified="2016-10-05" version="1">MGKNIQNALYVNPKSKPISLPLKNIQVAITKVRDKIDDRVKFITHIETFDQVHIFPAHAFVKRETEAVTPKNDWLEDIQNQFQTAIKNVQEKAAETFNPDEIQKNLKAIVDTFEKTINDLKTNTEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVV4</accession>
    <name>A0A194QVV4_PAPMA</name>
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        <submittedName>
            <fullName evidence="13">Protein apterous</fullName>
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        <name type="scientific">Papilio machaon</name>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="146" mass="16599" checksum="3FC3566ABF7F8B6A" modified="2016-10-05" version="1">MCYIEQRESSLLVSDLNPDYLEMGFRGGGGLGATSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLSQKTGLPKRVLQVWFQNARAKWRRMVTKQENKMAEKCSPDATLEMDMYHGPMSLPPHSPPYSVIGGPPSPNSMDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWA6</accession>
    <name>A0A194QWA6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_12693</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWA6"/>
    <dbReference type="FunCoup" id="A0A194QWA6">
        <property type="interactions" value="1341"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWA6"/>
    <dbReference type="InParanoid" id="A0A194QWA6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="28"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="327"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ07851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="48267" checksum="88D10D58A2FE7B49" modified="2016-10-05" version="1">MKEKILMNTCNLHISGDDSNMSKIKAGPVVDVLGDEMTRIIWDLIKDKLILPFLDIELHTYDLGIEYRDKTEDQVTIDCANAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWEKPIIIGRHAHADQYKATDFVVPGEGKLELIWTPPSGEPIKHVVNDFKGAGVALGMFNTDASIVDFAHSSFKYALGRKYPLYLSTKNTILKKYDGRFKDIFQEIYDNEYKAQFEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHYRFYQQGKETSTNPIASIFAWTKGLLHRAKLDNNDELKKFAETLESVCINTIESGIMTKDLAICIKGMNNVKRSDYCETFEFMDKLAENLKKSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXL1</accession>
    <name>A0A194QXL1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 19-like, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXL1"/>
    <dbReference type="FunCoup" id="A0A194QXL1">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXL1"/>
    <dbReference type="InParanoid" id="A0A194QXL1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="310" mass="35637" checksum="C903149D6CC0FADC" modified="2016-10-05" version="1">MRRYYYTTIQHLPKVAFGRTAVTCSLGFSLFTWLGFNKKLSAEDELIKTIKHCVLFTQRGEYEKAEQLLHIALRQAQQMRNESGVTYIYDVMANLALEREQLDKAKQLFVAVTQRIMAEGAKEDDPRVIHISAKLARISHLKKEYSTAKLGYDWCLSKLKNLPPEALNEMEKLIALTEDWYGRLLVDYENSNKGLDLMVSSLIRMEKLEDVEKEHIVIQMNDIATVCDHLEKYDEGISYLLQAIEIGKQLPDMDELGAVYVNLGRLYMKKMLLDKARKSCGAGWKLGVTAKNDDVKREAELCFKEIKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ54</accession>
    <name>A0A194QZ54_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ54"/>
    <dbReference type="InParanoid" id="A0A194QZ54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="77" mass="8418" checksum="04BEE1B307B9810B" modified="2016-10-05" version="1">MTSTVSSRPRDCLGCRIVGAAGLIGIGAYLANVAWKNQSFIGKVTFSTVSLAFVTLGVQRYKQEFPFEKKTEDIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZT1</accession>
    <name>A0A194QZT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZT1"/>
    <dbReference type="InParanoid" id="A0A194QZT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264770" evidence="1">
        <location>
            <begin position="26"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="430" mass="48419" checksum="540BE4C5B11FAA21" modified="2016-10-05" version="1">MLSENRWKVILLVVASIAAIEASRALSIVYQKPRTTPMFVPKNFYRRAKQSRVLFLDENENHQPLGRGEIDLTTDKYTSKIKFDDATDYEFTSPDEGTSSTKILDETPSGNDRFYEPLPRFRAPAFQVYPKYYQGRFGRPYAPGYAFDPYTFAPAVRNGFYGPNSGWKARSPRVVFPYASDNVNSVQTNSHAGPNVNDNVVFREQNFGTNDIGAEEQSLQDIGTGSADAFAERDANDSHRARNDEKRNDFRIKKIGTPLKLEKPMFVQTGITKNVQYLKRRDIFVYPNETEAVLPKFKPITDAQMMRISEILKEMTESTKESTNNLRKGRLLDSTAHVSASTQEEINSDIIESTLDRQDDKKCFQGGTCEFFMYCWMVGGLLDGSCGGLLKGCCHRNSKAGILGVQDSNSLDYSSNEGLSYGPVINDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0W8</accession>
    <name>A0A194R0W8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative cation-transporting ATPase 13A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_14986</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0W8"/>
    <dbReference type="STRING" id="76193.A0A194R0W8"/>
    <dbReference type="InParanoid" id="A0A194R0W8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="296"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1040" mass="117397" checksum="02003E7BAA7271D8" modified="2016-10-05" version="1">MPNMSKSSVVSEEYEVIGDPQWQVFENAVDDQIIRIFFVDNKGLNSISNLNSEEKKEYEVIGDPQWQVFENAVDDQIIRIRGYKYSKLRSILFHSVCLALGGLPYFALSNYPKYYKLQYIKSSLKYANVICGKCVSHPEKKFDMEPVYEVDLNLSNHRDNKLRFFIYQQNRYVWLSDHGVFINVQTLNEKMTINLLMENMCGINKRQQNELLKLYGYNSVEVDVKSYWSLFTNEVFNPFYLFQIFSIVLWSLDEYYQYATCVFFLSVGSCMLALYQTKQMSIKLHEMASSTNALTVRVLRPTRGGTGREECVVTSSRLVPGDVLVLPPDGCIMPCDAMLIAGSCIVNESMLTGESVPVMKGPPCLSSEVYSTETHKRHTLFAGTHVIQTRFYGNNQVLAKVVRTGFYTAKGEMIKSILFPKPFVFEFYKDAVKFVIFMFCIAAIGMTYSVWLYILRGSSAGTILLRTLDIITIVVPPALPAAMTAGIVYSQQRLRANRIFCVSPARIVICGKLQVMCFDKTGTLTEDGLDLYAVIPATEDKFGRCVVDINSLSTTSPLVQALASCHSLTSIQGELKGDPLDLKMFEFTQWVLEEPGPENNRYDNLIPAVVKPRTAANGNAQDLDNYETLMEMPYEIGLLRRFHFSSSQQSMGVIARVLGQPQMVYFVKGAPEKVAGMCDPKSLPENFSTILHEYTSNGYRVIGLAHKKLDRKMKWVDAQRIKRDNLECDMIFLGFLVMQNSLKKETSEVIKELHDAQIRQIMKLVLITVGSHLGDDTRPPLHMEVVGEDGPPLLSMESYVIALEGKTWAVIRAHYPEMMRTVIKKGMVFGRFGPEQKTQLVTSLQEEGLVVGMCGDGANDCGALKAAHVGISLSEADASVAAPFTSKEQNIRCVKHLALEGRCALSTSFAIFKYMALYSLIQFFSILILYNCVSDYMVLTLVTQFAFVLILLLCPWVWLAEVMEIMPVDLHDQDQTYFRIYLLIIPILHLVLAIAIEATLSEVDKLGSFFRTFRRRCADKEDAADLTCPLWLPDPASPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0X6</accession>
    <name>A0A194R0X6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0X6"/>
    <dbReference type="STRING" id="76193.A0A194R0X6"/>
    <dbReference type="InParanoid" id="A0A194R0X6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="478" mass="54011" checksum="21F3FFBC4355E14A" modified="2016-10-05" version="1">MSQQLINEQSKYILDLFSEQTIDSQALDILSTQVQKRFPKTEHFNLCLLLSSLITGGDLSLPGQRVVALAIIFDTYKQENPFSSLFLHLLEGKPGLLPLAPQERLFIGQLFGFLPVNIKDILKKTAKQVMLTEVVSKDLDFDYSSLQSVLAERATETSSVAKATVSALIPLGDGSPPNRIAMKELLEALMGNDYLPLHRTLRAAGPIPPPTFLLDPTEISFADEGVWKNLVNHGAYLPLYDTDYEGLLGLKPPEKVPERRVLQQHKSKEEKKERKEEREEKKPEEKDTVGAVSEARELTQLALKGALSVPHQQRLLALLDQEPNIVYEIGVTPYQLPELVENNPMVAISVLLKLIHSQHITEYFSVLVNMEMSLHSMEVVNRLTTSVDLPVEFVHLYISNCISTCETIRDRYMQNRLVRLVCVFLQSLIRNKIINVKELFIEVEAFCVEFSRIREAAALFRLLKQLDSGEGHKDTKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R119</accession>
    <name>A0A194R119_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Striatin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A194R119"/>
    <dbReference type="FunCoup" id="A0A194R119">
        <property type="interactions" value="1137"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R119"/>
    <dbReference type="KEGG" id="pmac:106715039"/>
    <dbReference type="InParanoid" id="A0A194R119"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Striatin_N"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
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            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="682" mass="74868" checksum="A6BDC3F0AC843663" modified="2016-10-05" version="1">MKIPTAMDDSSVSHHNGGQVGSQIGVSVNNKQNEESSQSVQYSIPGILHFIQHEWARFELERSQWEVDRAEFEARIAFLQGERKGQENLKNDLVRRIKMLEYALKQERAKFHKLKYGVELQQGDVRPPPEEPPAEPEPAEKAQWKQGRQLIKQYLQEIGYTDTILDVRSNRVRTLLGLNNEEQAEDPNYRNNDNKFRERCGDSPINSLIRKYDYGGKEQRKGGGSTGGGYNEEGLSVQETAAVFANFEFLANQEMDMDEIDDLDANKPHHAPPKQGEEVDNEAEEVLNVLNLLAESEAEGGGQGDECPVGVVGGGVAAAGGGEADEKPLALGELAQLTVSNEPEAYDVAGANKESFRKTWNAKYTLRSHFDGVRALAFHPTEAALVTASEDHTLKLWNLQRTVQAKKSAGLDVEPLYTFRAHTAPVLCLAMGLPRSEECFSGGLDGTIRVWNLPPPTADPYDPYDPAVQGPVLREHTDAVWSLACAHGRLLSASADGTARLWAPRAARPLLCTLRDDAIAAPHAPAPAVAADFADGEAAAAVVYRDGTMLLYDLETTQSFLRIACDSPANRIRAHPTLPLLVSAHEDRHIRFWDVGSGRCAHAMVAHLDAVTGLALDPNGLFLLSGSHDCSVRLWNLDTKTCVQEITAHRKKFDESILDVAFHPLRPYIASAGADGLAKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1F6</accession>
    <name>A0A194R1F6_PAPMA</name>
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        <recommendedName>
            <fullName evidence="5">Replicase polyprotein 1a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013108295" description="Replicase polyprotein 1a" evidence="2">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
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        </location>
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            <begin position="300"/>
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        </location>
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            <end position="178"/>
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    </feature>
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            <end position="199"/>
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            <end position="239"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11628.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35394" checksum="D7D3125C57472CBF" modified="2016-10-05" version="1">MLVAIICQLIVATIASPYQKYPFVFLLDVGNEELAKTNTEKIRVSIPGGSLAVRYPAISEGDLITHVRVSSIDFGSDLKASILDGGPGYKYVVLVFLGNPGVKCDAVIILQTLPNNQDSSNNDQGTIDSWGVNSISDSAINNSVEDMSNENKEAIKSNKEADLTEQSSNVHNNAQLSNGDDESGDNSEEIKDELDDEENGQSIQDKVSNENESNEQIDDKIEKQDSSNDSDDSEDDDDDHAERLQGYQSKYNSNELESETINDKSLDQDSGMYIKDSIYDAQVHNPANEDQMITDEEVYNDSDKFKDSNNNNFDSEYGAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1N9</accession>
    <name>A0A194R1N9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1N9"/>
    <dbReference type="FunCoup" id="A0A194R1N9">
        <property type="interactions" value="1043"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1N9"/>
    <dbReference type="InParanoid" id="A0A194R1N9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="264" mass="30565" checksum="193735B5F75CCA89" modified="2016-10-05" version="1">MAEVKVVCLNSKDIKNITKVKRAISKVNESENTDSDEMKELTVPKEDNDHSDKQNKKEELEVQEIKDEDKNNKLFLNTSDLDWLYVHLNKKREEGKDVPYLHVLFEGSQIELPENGIVKRNPDLEARCVKLRAQMEAREYRKMTKSVDNVRMRFPEDSISYQMKQLNRQLIAIGQFIISIFAGFLFGFRGVEWMVGNLDFGFRLLLGVMCALVIALAEIYFLAKKLNEELNVPETVQLGGPPKFVNNPDNGYKHTAWDEKEHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4S5</accession>
    <name>A0A194R4S5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4S5"/>
    <dbReference type="InParanoid" id="A0A194R4S5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="47346" checksum="03B83F7F296BC62A" modified="2016-10-05" version="1">MNLTVIQRFFVANILTVCYSVLVLFKFLLIFLRNPLRNPWQQKLVLVPPARLSDPKYGVHKYVKANNIKLHYVESGDPNKPLMLFLHGFPEFWYSWRHQIVEFNKDYWCIAFDMRGYGDSERPEEVSAYKIDLLVEDVRDLMRKLGRSKCILVSHDWGGMVATKFRDTHPDSLDALIVLSSASREAGSHELWNNPEQKKKSWYMLLYRMPKIPELMFQMNDLQIFDMLMKRRENYVDDNDIECYKYWFRKQDVREMYMLLYRMPKIPELMFQMNDLQIFDTLMRRRENYVDNNDIECYKYWFRKQGALTPPINYYRANFQLTFPDKYKDENVPMIVANGEKDPYIATSTLERMKAEYKYIETVLVEDAYHFLQQESPEKVNKIIRDFLLKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5Z1</accession>
    <name>A0A194R5Z1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium and integrin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5Z1"/>
    <dbReference type="STRING" id="76193.A0A194R5Z1"/>
    <dbReference type="InParanoid" id="A0A194R5Z1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="19396" checksum="6627E54A4B75CD8B" modified="2016-10-05" version="1" fragment="single">QDLTYFTKKEVLYAHQKFKALAPEKVGHNKNAKLPMAKILQYPELRVNPFRDRICKVFSSSNDGDCTFEDFLDMMSVFSETAPKAVKAEHAFRIFDFDGDDMIGVSDLREVIKRLCGPEHKLSDSEIQQLVQNVLEEADLDDDGALSFAEFEHIIDKSSDFCHSFRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R687</accession>
    <name>A0A194R687_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R687"/>
    <dbReference type="STRING" id="76193.A0A194R687"/>
    <dbReference type="InParanoid" id="A0A194R687"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="13097" checksum="54CC8BB72F0CEE73" modified="2016-10-05" version="1">MAALCVPHIPTPAPAPTPTPTPAPTAVATPTATPTATPPAGKHKCPRKQRVAPPHSDHHLPPPPDILEEQRTEVLTGQPRNTSLPDSERNMLEVADPSGPPTLATSALHALDIQFCAQGKSHCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAJ9</accession>
    <name>A0A194RAJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAJ9"/>
    <dbReference type="InParanoid" id="A0A194RAJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="23247" checksum="B17943F3A7E76EE0" modified="2016-10-05" version="1">MQRTATKQRPSSTQKVAEITTPAHSNIYIPQYSELETDSESEYYTYLAHTSLPERKENKTPTRETNTLHSYIEEAKSAHKQAIVNLNNSRNLKREIKKGIENAVKRLFNVFNETIKELESSNLRKNTNSTHLPPSPPPPLRLGPRVVSRIFPVRKSRENGEKLKRRDNVDLVPDVLEGRDLHCWIALQKPSRYQFSKGKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBQ4</accession>
    <name>A0A194RBQ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBQ4"/>
    <dbReference type="FunCoup" id="A0A194RBQ4">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBQ4"/>
    <dbReference type="KEGG" id="pmac:106710586"/>
    <dbReference type="InParanoid" id="A0A194RBQ4"/>
    <dbReference type="OMA" id="YEFYIGI"/>
    <dbReference type="OrthoDB" id="10051670at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF555">
        <property type="entry name" value="TETRASPANIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="249" mass="27355" checksum="945BAF6952213E5A" modified="2016-10-05" version="1">MAGAGRGDGQGPAVGKLESQIYCIKYTLFCFNVVLWLFGVSIFALCLWICFEPGFNEWMRILELQKYFIGIYIILIASLGIMVVAFLGCGSALMENVVLLYGFIGSQIALFVFGLVGACVVLDFSTYDSSIQPLIKDVILRLINNPQHEGSREILRMVQEGIGCCGADGPMDFLNLNKPLPSECRDSVTGNAYFHGCVDELTWYLEGKTGWLAGIVLASCMICVVNAVMSLVLIQAVKKEEDEAIVYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC24</accession>
    <name>A0A194RC24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein escargot</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC24"/>
    <dbReference type="FunCoup" id="A0A194RC24">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RC24"/>
    <dbReference type="KEGG" id="pmac:106710751"/>
    <dbReference type="InParanoid" id="A0A194RC24"/>
    <dbReference type="OMA" id="RRPRYQC"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055059">
        <property type="term" value="P:asymmetric neuroblast division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000693">
        <property type="entry name" value="Snail family zinc finger 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000942">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001114">
        <property type="entry name" value="Zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="41670" checksum="837ED8EC8F13726C" modified="2016-10-05" version="1">MLVEDSQMSSSPMTKKYAHCPLKKRPVREERPATPPTTPPHPAHLATRLYYDYNCDMENDEPENLSTKPEDLSKTGNYPSKASSPMSTASVKVEPREWQQQHLDYLSACRSRLEPTPAPPELARPTPQYAYLPTLYTYPFEELYPATPTISPPAHPQLYPRYSPASPPSSCSPPPCPEDLRSPGSVSSDSGVSVSAPRRPRYQCPDCAKSYSTYSGLSKHQQYHCAAAEGSLARKSFSCKFCAKVYTSLGALKMHIRTHTLPCKCHLCGKAFSRPWLLQGHIRTHTGEKPFSCHHCRRAFADRSNLRAHLQTHSDVKKYSCTGCGKTFSRMSLLSKHLEGGCGVAGASPYEYRPEALPQSHVHQALPPTAPVHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDD2</accession>
    <name>A0A194RDD2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dystrophin, isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDD2"/>
    <dbReference type="STRING" id="76193.A0A194RDD2"/>
    <dbReference type="InParanoid" id="A0A194RDD2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="33388" checksum="169970EE508595EC" modified="2016-10-05" version="1">MLEKPTRSPASLRGYEATTLAPPGPGRSAGGIYFDEVGKRCTNASANKTQSTVGTNFIYSLQIHLWIFLSISMSALREHWAEANARVLQRKAQLDAMLGDSQRYEARRRDADAWLTRMEARLAAMAPPGHTADVLDMQLRDQKSFHAEVHQYKHQIELFGQLTQRLIAVYRNDDTSRVKRATEAINHRYTDLNNSIVARGKALHSAVSSLQNFDRSLEKFVGWLSEAESLLDAAERDPHLLKNEAEDKLERERGTKSRGKSDAFTRIKKYWRRDNKPLLSLHNLRLYPLAMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDI0</accession>
    <name>A0A194RDI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDI0"/>
    <dbReference type="FunCoup" id="A0A194RDI0">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDI0"/>
    <dbReference type="KEGG" id="pmac:106710358"/>
    <dbReference type="InParanoid" id="A0A194RDI0"/>
    <dbReference type="OMA" id="WNNQENL"/>
    <dbReference type="OrthoDB" id="5988811at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="212" mass="25011" checksum="82C957D8AEB77944" modified="2016-10-05" version="1">MISHKSILKRALPMLMQCAEAHRKPRWLPVAKSKIFRIPKRPVITEEERIELLRINNNYKTQMRAIKRFYHEEMIREKSTLESASSEMSQRLEAEEWERCVKINDTWNAQIAAEREERRKKELQEMEEFALARMEAKDKELRNRIAKASEEIKEQKKLSNTFITPENLEEAIDQALANPIDYNFAIDLQGQQYLGRDTPIPTKEQKKAAANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REN2</accession>
    <name>A0A194REN2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-lysine N-trimethyltransferase SMYD5</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
            <ecNumber evidence="10">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET and MYND domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">[histone H3]-lysine20 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">[histone H4]-lysine36 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_13462</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EC" id="2.1.1.372" evidence="10"/>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REN2"/>
    <dbReference type="FunCoup" id="A0A194REN2">
        <property type="interactions" value="1018"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REN2"/>
    <dbReference type="KEGG" id="pmac:106711461"/>
    <dbReference type="InParanoid" id="A0A194REN2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10521">
        <property type="entry name" value="SET_SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044422">
        <property type="entry name" value="SMYD5_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="43521" checksum="997C3B94658D21C9" modified="2016-10-05" version="1">MAGFEVRTSNSKKGKGLFATKKYDKGDIILEEDPLVSCQFAWNAAYRYLACDYCMRPLETPEQNVRRLSCKPDIVLPHANCFDINLENIATCDQCSTLYCGEECKQRALDTYHRSLCYDTTDAQHPIVILLETWKQMHYPPETTSVMLLVRILAFIEQSNDPTAAASVIKQFCHRTVNEDAELVHKLLGEQFTDQLNTLRDMTANVINGEHIQEFLTPEGFCSLMALVGTNGQGIGTSPLAMWVNSVSELTMSDDERQQLDLFIDKLYQYVEQESGIFLNTEGSGLYRLQSACNHSCAPNAESSFPYGNHRIQLKAIDLIMPGDEISISYLDECSLQRSRHSRQKELAQNYLFVCWCERCLAQGSQPDCTSEEEMSDDEIDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFE8</accession>
    <name>A0A194RFE8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_05980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFE8"/>
    <dbReference type="InParanoid" id="A0A194RFE8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="188"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="522"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ16025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="689" mass="74166" checksum="40ECB3F8ECBF9B5B" modified="2016-10-05" version="1">MPPTQGATAPSYQTRSMAREMASYSRAGKHAEEVLKSIRTVIAFAGERIESDSYLSLLLPAENAGRWRGLLTGVGTGVHWLLTYGMNGICLAYGTRLVLADFDRPTEHRKYVIGVLFSMWSIKNARIAQILFNVYMATQSVTFCAPLAEVFAAARGAAATVFPLLERRPAIDCLSLGGAQPDRLAGDIRLEGVHFCYPSRPDVKILQGFSLHVKTGECVALVGSSGCGKSTVLQLVQRLYDPQRGTVQLDGRDVAALSLPWLRTRLGVVGQEPVLFRGTITENITIGVSGASSADVRRVAELAFAHDFISRLPNVSERGASLSGGQKQRIAIARALLRQPTVLLLDEATSALDPRSERAVQAALDRASAGRTTLVVSHRLSTIVNADRIICMDRGAIVEQGTHKELLEAKGFYYKLVTTSSDNREPDVIESVPEEDAPPSSPPSSPPRPLRPPHGHLSARGELEERMSARSSAGSATSAALAAPLAAPLAALADTCDDDEEVRPLTDWQLLRLNAPEWVSLLVGAVAAIVQGACFPVMAWLVGQAAGIFVLTERGEVLRQADLFAGMCVLVGAVAALAMFLQNATFTHSGLRLTNRLRHQYFSAILRQEVGFFDKASNRVGAICARLSGDAAEVQAATGLRLGLMLQGFSSMLIGVVMAFCYGWKLTLVGLAILPLVSALRFKRTRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFM8</accession>
    <name>A0A194RFM8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFM8"/>
    <dbReference type="STRING" id="76193.A0A194RFM8"/>
    <dbReference type="InParanoid" id="A0A194RFM8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF154">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="38844" checksum="15AE4FC46B9DF234" modified="2016-10-05" version="1">MLDDLLNANEVPCVENAEMGSTAITIYLKAIEKYCGRFVSVDNRTLTYQKRNLYEVLLKHPHENATVRSGRPVILLEAGQQAGIESVNFALFVIEQLVACKENLYMLKNARWVILPSTNPDGREFTRYTPGNWQKNLRFSEDDRSAGVDISRNFDESFNDCGIILNGFDHNYPGKKPFSESETSFILDVLNRYKNKLRAYVSIRRDGHSLLYPFASVNSSAVDTDKLREKAAEIISKVNHKFGFIEYLTNSSIIEMNRKPVCGHSVDFVFMKYNMPYAYEMRVFLESDHKIMTKFQSLPRGYDITLRNGYFAVIKELYNIVIEEHRNRTYLRTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH15</accession>
    <name>A0A194RH15_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH15"/>
    <dbReference type="InParanoid" id="A0A194RH15"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="985" mass="115344" checksum="8438B6CE5D131BBE" modified="2016-10-05" version="1">MEYDIINTTSGNDIIASTYADIYIKYDKKVKSRVEKTEQKVEVSKQSDSAEEIWTSPSDLLIGIIQMKPPFTSKIIKSKTHEGIINIGGDVLQKEYEEFLLSLKKLLHENDECWKFVLMNEKEEINKKVKIKYQNIFKTKSSLMTKEIENFYENTLKELEEHVKKEVETVLSSVYANIISHLNNQIHLKLLKERKILEDSLNKKYLNEIKKIKRYYALLLRNEHERSNQLTNYALKERNNAVDMFYKQIICERLTSSIYVLCTERKKCKIKNIMLEKYHNAEIHEIVEKIKQKRDLLQSLKDKDVCILDINKDWEEKIKKVLQLFLKFISFALKLLPEQTTFLLQLEKLVQLQLDDIKESDRSKSSILVEESNIFKFEQSGPSDEICTKQPFVIEGDTSATPPIVYGSRETIPSDVDLPYFRLQRQFIYAKCHGFEEIKKFLDSQRCKCRTPVEPQPEMSPTTSKVQSVQSSTSESSDESFLFENFHRLPDCPVRKCADSTLVNYFPYLNSYFDYSEENFRRVEAIFGVPSQKEPTENLLDAKDIANSELPFAETKEKYHNIETQCSSDEDVRYDPPCPCLYNLLKESAGNETVNNFFSKSVGDTCIKRQKMLKEITKSKINVKCSKYEKSEAIRRNKMYWKNVIAKLDKDKDQLNAYELKDLSRELSSDLCERVCAILDYEMVQESNDKIATKTQQQTSKIRKEPLFSKRKSIIIERDLESDTDVEICSSDDEQDRTNIHRQFLDKPEREQITWNTRFLRPEREEEKSLIKRANDLTERIAQDFCDYMRALGGDQQSQLFTPKSIKELFQVEFDTHVARSLQVVPKEMPTVINKIAELTGNIELSRNSALAREITKDIKIEKRPDRLTAFGRSLPRREQWRTPQNDTKNQWRSAKHVPRDLVSLKTVWEGITNIRSVREYCRWMIQHPEHRRAPYLNSLGMFDPAVLNARFTMELQHASPTTHNNAPAPIDHLRRRLSQLADTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH84</accession>
    <name>A0A194RH84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH84"/>
    <dbReference type="InParanoid" id="A0A194RH84"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265190" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13083" checksum="775592652FB99254" modified="2016-10-05" version="1">MVGKFTITLVSVICLVSVCTSKFVESSDSLQSNLQSMYKNIIYLKKIDEIQRFKRNTDEPMSLSFQDMSENIKNFCKAVPALLEPLSVQARDIIHEPCNFGYIKVNGKCVPEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHL7</accession>
    <name>A0A194RHL7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHL7"/>
    <dbReference type="InParanoid" id="A0A194RHL7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="53" mass="6169" checksum="7ED19F960D713E91" modified="2016-10-05" version="1">MEICKENGVVIMTSFVDQVCWDLQCNVNRPPCTRRRRVRSCPQPSRYVPSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHP5</accession>
    <name>A0A194RHP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHP5"/>
    <dbReference type="InParanoid" id="A0A194RHP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="69" mass="7691" checksum="A75629D227389B14" modified="2016-10-05" version="1">MQSSPFLDDDSQIQRVGPKSGVPSTTLFSSARGCRAKFLRQDDDLDDDEGSRRSSIAEDRVLKCADTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHP9</accession>
    <name>A0A194RHP9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Teneurin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Synaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RHP9">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHP9"/>
    <dbReference type="InParanoid" id="A0A194RHP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000033">
        <property type="entry name" value="teneurin-a isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin TTR-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin 1-4-like FN-plug" evidence="6">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin NHL" evidence="8">
        <location>
            <begin position="302"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="9">
        <location>
            <begin position="709"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1491" mass="166127" checksum="C6D079BA3B9D4D63" modified="2016-10-05" version="1">MRGQVVSPQGLGIIGIRVSVDREARFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFKPLRKTVFVPWNQIVVLPPVQMELSDDSVKVPTPRAPPRLDWSPMPQWWEAERPPCAAHDHERLRPEVVAMPPLASPAASSATTTTVVYPEAQIVSESIGIPGSLVQLTYRSSQAAGYLSCVHVQLTRRVVPASLARVHVRVEIEGSLHTHTYEADPDLTHIFAWNKRNVYKQKVYGQAHAKISIGYEYSSCSSIVWETQTATLAGFDVDISDIGGWGLDIHHHYNFHEGILQKGDGALLHLKRYPRTVQVVMGTGLQRSLECPDHCNGKAADSRLLTPTALTSGPDGSLYVGDFNLVRRITPEGVVTTVLQLETTQVAYQYYICISPADGYLYISDSERHQVRRVLILEKVRDPSMNSEPVVGNGDRCVPGDDTNCGDEGPAIKAKLAHPKGLAIAADRTMYIADGTNIRAVDPNGIIHTLVGHHGHHNHWSPVPCRGAIPPYEAQLQWPTGVALSPLDGSLYFIDDRIILKLTVDMKIKVVAGQPSHCRLGSDGKPISKVTNKTNTEFREDSSLGTILAIGFAPNGILYVAESDSKKTNTIKSIDPSGKIMHFAGKLQENMKELSCECNTSLSATVVPMNPRDEGAGCPCKLSVVAGDEPPTSTETLLSSNAKFQTISALAVTPDGVLNVVDQGSLHILALKHYLPSHDENGEFRIPYPPTSEIYVFNRYGQHITTKDLTSGKTRYSFLYSKNTSFGKLSTVTDASGNKIQLLRDYSNIVSSIENTQDHKLELKISGIGYLTKITEKGTSEIELDYDANTGLLNSRSGAGDTVIYNYDELGRVTKIIMPSGEQVHISSGLAKNYGLAVTVSNPSSTIPVGVAKKCEYVLHGQSFKQITINNGKQVTEGRIYTNNTLVIETPWSGKFESVAAAKHPLLEAALPIEAEMLHMWSHQSTTFGDGLVNNMYSLYSLVGDVRNPQQTLNREIWVNDSRVLIIEFDQFKSRETFFNADRNPLFTIAYDVAGLPLSFTPHGAGVPLNISYDRFYRINGWKWGVTEETYNYDPHGMLSEITSTQDGTKFIYYNEANLVSKITLASQRNFKYSYDKSGGLTHVILPSGTNHSFSVQPSIGFLRVTYTPPGSSKKYLQHYSHTGELLQTVFPGDGARVIYRYFTTNKVSEVVHGDGQTQIHYAENSGLPSEILHVDRDVDYRWESTYAGGLLMEERLDYGAKTGLSNAKIIYDYDNNYRIISVQGRIGGQTLIPHHIVYNSKTGAPEILGQFTVSKQKWNETSVYDGIAMFSRVLNEQFLEKEVTVNIHRMEVFRMEFSYDKHGRISQTRTHTRNVGVNTYTNVKNYTWDCDGQLTGLEAQEPWGFRYDDNGNMLSLTYRGNTIPMEYNEMDRIIKFGEGQYRYDSRGLVSQNAREERFQYNSKGLLIRATKRGRFDVKYYYDHLDRLSTRKDNFGNVTQFFYTNKEKPHEVTGSSRTLGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHU6</accession>
    <name>A0A194RHU6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_13756</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHU6"/>
    <dbReference type="FunCoup" id="A0A194RHU6">
        <property type="interactions" value="2079"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHU6"/>
    <dbReference type="InParanoid" id="A0A194RHU6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ16900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="303" mass="35209" checksum="F9B2770661EDBF72" modified="2016-10-05" version="1">MSSQMSATNFNLLGANSLKDEITIKNVWNYNLHEEFYVIRRVVQKYHWVAMDTEFPGVVARPIGEFRSTADYQYQLLRCNVDLLRIIQLGLTFMDENGRTPPGCTTWQFNFKFNLQEDMYAQDSIDLLQNSGLQFREHEEHGIEPLEFAELLMTSGIVLMDNISWLSFHSGYDFGYLLKLLTDQNLPQEESSFFEILRMYFPTIYDVKYLMKLCKNLKGGLQEVADQLELRRVGPQHQAGSDSLLTGMAFFKIKEIFFDGNIESTSGHLYGLSTYVLVYCARIITINVFSSSLFCFVRQQFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHV7</accession>
    <name>A0A194RHV7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase SIK3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHV7"/>
    <dbReference type="STRING" id="76193.A0A194RHV7"/>
    <dbReference type="InParanoid" id="A0A194RHV7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="60" mass="6731" checksum="9A94362D2CCA4613" modified="2016-10-05" version="1">MANDINSELKNKHFPINQLVCVGNYQLEKTIGTGNFAVVKLATHVITKTKGYTALRVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI51</accession>
    <name>A0A194RI51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI51"/>
    <dbReference type="STRING" id="76193.A0A194RI51"/>
    <dbReference type="InParanoid" id="A0A194RI51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="42983" checksum="F83FFB8A13895BA7" modified="2016-10-05" version="1">MNEVHARDDVVYDTDINFRCVELKSLSFDKASLRRSYTTTSCLGPLLREELSWRAVVSEAERMVGYPTSFLNLRWLFNDEIAVAATQLRKLVGTNHPLLKSAKNILIGSKSNLQSVGLIVLLVSKAAGFNPAEFSQDLHTSGVLHAQRALAEIVEMKRTGHIIHKTMANLQEKEKHGKKYDDLLCGNKIVLLTGGNEIIKRYDWENENNLGTLGSNDYLGRGIDEWKLRTMLTSGSLLAKGCQAAMKLSKQSEEMEREAYKLGGHLAMIWQLYLDVKDFYTHPHSYSMVGAPVIIALWEYPTIYGHIYEAKLEKKGVEIKQLHYAVRSTRAIEYLRIFLDQELDAVLRCTDMFPVEDARHALHKMAISIHGEAVEFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RID0</accession>
    <name>A0A194RID0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 1-gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eEF-1B gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194RID0">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="438" mass="50088" checksum="91ACCA4B1E0047E5" modified="2016-10-05" version="1">MRERGSAGVRVAPFPREVLYTYPTNFRAYKALIAAQYSGVDLKVATGFVFGETNKSEEFLKKFPAGKVPAYESADGKVVLTESNAIAYYVANGSLRGEDVETQARIWQWASWADSELLPASCAWVFPYLGIMQFNKQNVERAKSDLVTALRLLDAHLLTRTFLVTERVSLADIVVFCTLLHAYQHVLEPSLRESLVNVTRWFSTVAHQQQVAAVVGELALCAAPPTYDPKKYQDLAHKKEGGKKDKKAEKKEQQPKKKAEAPAEPEELADDPEEKPKESKDPFDSMPKGTFNMDDFKRCYSNEDEAKSIPYFWEKFDPENYSIWYAEYKYPEELAKVFMSCNLITGMFQRLDKMRKQAFASVCLFGEDDDSSISGVWVWRGQQLAFPLSPDWQIDYESYDWRKLDPASEETKRLVHDYFSWSGVDSKGRKFNQGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJM8</accession>
    <name>A0A194RJM8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA 3'-end-processing factor FIP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJM8"/>
    <dbReference type="STRING" id="76193.A0A194RJM8"/>
    <dbReference type="KEGG" id="pmac:106707780"/>
    <dbReference type="InParanoid" id="A0A194RJM8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
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            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="384" mass="43765" checksum="F808EED3198188E8" modified="2016-10-05" version="1">MAETAMETAPTDENDDNWLYGESNNEQVESETAKNGDKTEPPKESAEVAADNEEKEPDENDGNNEDSQFNDEHFADVGRDDQDQGNDADSQDNGDSDSDDSDDVKVTIGEIKSGPQYGSLNIKRGVGLVASGVSEKPRGGTTTGNKVTLEDLEGPGSINGVPALEFNIDTIEDKPWNKPGADISDYFNYGFNEVTWSAYCERQRRLRVSEAGVGLHAPPPQRPPPQERGRNLGPMRTDDAMQPPMQNNYQVRENTIQVMTAERREYGRGGHVRDTPPDYFGAPPPEHYYPPAHAPAHPPYDEPWDRERDRERSRSIKPDRVREKSYRRERSRSRSHRHKSRSRSPRPRERSRDRDRSRDRDRDRDRERSNKSKTKETKEKEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLA3</accession>
    <name>A0A194RLA3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLA3"/>
    <dbReference type="FunCoup" id="A0A194RLA3">
        <property type="interactions" value="1796"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLA3"/>
    <dbReference type="KEGG" id="pmac:106721558"/>
    <dbReference type="InParanoid" id="A0A194RLA3"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="29939" checksum="465020556D23139C" modified="2016-10-05" version="1">MFYLIGLGLGDAKDITVRGLEIIKKCDKVLLEGYTSILTVGKEALEEYYGRPLILADRELCESNIDDTLKEAKIKNIALLVVGDPLGATTHTDMLLRAKQFGVESQIIHNASIMNAVSCCGLQLYSFGETISIPFWTESWKPDSFFEKILENYSRNLHTLCLLDIKVKEPTEESLTKKVRQYMDPKFMTVRDAALQLVQIIDKKPDAGLTRESLAVGLSRVGAPDQRIALMTLEKMLDLDLGPPLHSLVIPASKLHPLEIDYLEQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM41</accession>
    <name>A0A194RM41_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SoHo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM41"/>
    <dbReference type="InParanoid" id="A0A194RM41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003127">
        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00459">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50831">
        <property type="entry name" value="SOHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SoHo" evidence="5">
        <location>
            <begin position="208"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1627"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1682"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1888"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1940"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1479"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1953"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1975"/>
            <end position="1985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2005" mass="226949" checksum="1CBF5A9B8A6EE040" modified="2016-10-05" version="1">MQSSRGLTLVSLSSVMRMMMMVLIIFSAVWRPGAPAPNVSPGAPVSPAAAVSPGAAAASSAPPPPPPPVWSPAASPQAPRKPFRPVHFEDTPPARRKFVNTEQNGCTSGSESEGRLRTSLSAPAAGLSALGATSRLPKVQNPTVTLLQKARENHLSRASNIQDRDPRLPRDRPSPPIGDPVHALRKGYLSEGEADRREYVHTGSRKMADANRKVEGIGPTTREGMPVALRSEVKDPSRWYKKMYDTIHKNKYDDDYVTIRYKNRQGQPPLRVSSSRSQYAYFDPRSGYLSEPEGGLGRLSACDAYDSDATTGHRRRTASVQEDRRDDFAYLPNNKYSTLASARASQEVYKNQPGRIENYVPGKSSVVDKEAKQWWDEVMDIFDGQNISSTTSLPQTSPKEKKDVTATILSKSNMARALKESGYESDSTLIFRRREETDAPLSPAERRAAYKDLQAGGEPPLRGFRSPAPPRQDESEIEYIPISSTLTKIRVHKKTPHPHEIVCYPLTKIKTSDINDTSNKIFKLDRPDLARDFPPAPPRRISSKNSKTLKFVTSSRHSSMSPIRPTVEDSNVNFLKNKLNNKLNRQNTHVIIKKDTKMNANKLSKCRELSISAPPSVNRKDMSSSTSISKRNIVERGSSSFSSPRRTLQPTEYSTQNRPGESNTSVVIENGAGRRTPISNILDKVTSLDKLWSSQKRNERIDAAKYRERSINKTAITTTSRPSPSKASSCLDTKTLPRNVTHKSRDMVRTSEKIQKLKSSNALPKPNFPLTYKSASNKSSRGSLQATSNISKSTSNIPSNTKKLNNIRTAVVTNLRKKKSLESIVIRPRSVPCHETCNKKTKYPILKKESTVKSKKSDTSLVVESGAENKSNNTEPEGFDYSYSKEITRKQINPKDLKETRDSVCSDSFFRHLFLGSAPVVNSLSEQSIMNSVQQKAKHFQSLPQTITHNTSNKFNSYLIHRKPVSHSRFKAWDKNSSPTRNYNARSVSWPGKMDGEIRKFQSLLKPDGFGSISSLSTIRSKSEPPTNKIYFSQTSRPVSPSIVFNKKTEIERKSVSPSKIIYLQPRSNSPYSIHRTPHVKFSSEETSKKLQNPIKTIQLENDNTLNTIFFSQTSRPKSPKVKSTPCKSRSQSTSPVSFRSPSYRRIHNARVQSRQLSESCSKENRTKSADSLEINKHRKNETTRAKSDTNLYANDPDYDEYIHDIQNSKPRTERFRELNRYYAYLERVAELEKTTSTCDLRHRKKDEEIIDFDRWKKIRAIERAEEELNNLYHKLKQAQSENSILFYPKDLNDFRWNSGKERGLRVKEKSVEDLKEEFQQKPYPETSESSQFQDRYKSLWRGKSVAETAFNINKKGEIEHKNSRITNKPKKSVSQDTSFSELQKKLGLKNHLWSSLSMDQVNALKNQLNAIYSKELETKTNKEHDKYTVEIKDTSNINKPALHVRCNSLISSPTTTGHGHELSKSDSIAAIAYSGSSEKDMKNNVNKLQMNLSEIEKKKISQSLSKEVLNRINKNEKSEVKTLEIKQNSNKEIDNTFTKNKNELKSRSDLESNLSSLTTRDIEDKRKRHIVYPIDNAETTYHSSTSETETGSSDISNKTVIFMGPNKEVFKKVEYFENVTSITKPNNIYSSRENSEKSKNPLKVNSYCRDNKEDQKPLSQSQSCTNIKELFGESEKNKFLSLPSQPDLHSRSPSPYSEVCISDRHTPDTLRYSSDEAMWRSRTPSPDPERYWRAYIKLARAGEVRRLARRFDSPSAAGAVLRRHRSDPEIARNVINWSAEEKNSSQRERCRAILPVVTRVPLRPTNRFMPHIDVISKLAALRKRTSPRSRSAEEALECRPGEVERIRKRFESMSLLGPIYSSAPDVRELHDIAPYLAGSWIAHRYPKPSDNNRSIPNPETLINGHKSPVKKETKLAMTKDSVKLSSILKCDQLAKQEFDPAAHRPASRYEPPRAPPRPPPAAWPQRLAPFVTASRHTVTFQENDSAPEPPRRVTHGSYSDTGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMS0</accession>
    <name>A0A194RMS0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_10663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMS0"/>
    <dbReference type="FunCoup" id="A0A194RMS0">
        <property type="interactions" value="1449"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RMS0"/>
    <dbReference type="KEGG" id="pmac:106721060"/>
    <dbReference type="InParanoid" id="A0A194RMS0"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000025">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="12931" checksum="B17A1876D5B10E86" modified="2016-10-05" version="1">MASKEGGEKTKNATGTGDNKEKRRKESILDLSKYLEKSIRVKFAGGREAAGILKGYDPLLNLVLDNTTEFLRDPDDPYKLLDDTRALGLVVCRGTSVVLICPMDGMEAIPNPFITQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNR7</accession>
    <name>A0A194RNR7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfotransferase 1C4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNR7"/>
    <dbReference type="KEGG" id="pmac:106708007"/>
    <dbReference type="InParanoid" id="A0A194RNR7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="39358" checksum="F8216BD273827D14" modified="2016-10-05" version="1">MTKEQKFPFTIQNVTEEEDALLKKYYKGYIRPFVRIGPHGYLWPAGYGDHAADIYNLDIRPDDIWVTSYSRSGTTWLQELVWLVQNNLDFDTASAIPVSTRYSFIEYPTLASEVRKPTPNSSIKGQRATEEDYKTFPNLPSPRYVKSHSPLSLLPPNLLDTAKVFHIARDPRDVVVSYHFMHIMFRYFDQSVQFKEFWNLFKKNLILHAPLEEQVREAFEQRDHPNMMFLLYEEMKKDLPDVIDRVCTFLGKEYTKEQKDKLNDYLQFDNMKNKSPFVSSEDEKKDSELKFMRKGKSGGWVQYFDDQMKKEAEEYMKKYLMCTKLQFPKLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPK8</accession>
    <name>A0A194RPK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="pmac:106707713"/>
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    <dbReference type="OrthoDB" id="3349449at2759"/>
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        <property type="term" value="C:endosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="term" value="P:endosome organization"/>
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    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
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        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="94"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="454" mass="52097" checksum="4356CB1900CB70A5" modified="2016-10-05" version="1">MSTEETLLNLDFDKPNSTITPPDDGVVSLSSSAEDICLVPEVGFEGNVDSPGLNRESQPLLSGRGDFEVSFNHFPDDPQFSELVWQAEVAIDNGIYPERIYQGSSGSYFVKNPGGKIIGVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRSCLIPNQGYLSEAGASLVDSKIGLKVVPKTRVVKLVSETFNYLRIDRERSRLKRAITEQFPNLRFNRMGLPPKVGSFQLFVEGYKDADYWLRRFEQEPPPPHLMRKFQLQFERLVVLDYIIRNTDRGNDNWLIKYDAPSANTNSDPINMTDPTEWSGGNVEVRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKRPFSQETKELVLPLLSDMNFVQELCDELHLLFKQDKGFDKGLFERQMSVMRGQVLNLTQALKDNKSPVQLVQMPAVIVERSKSGTTSSRFFDSFQQRFQHKSPFFSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPM1</accession>
    <name>A0A194RPM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chitinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPM1"/>
    <dbReference type="STRING" id="76193.A0A194RPM1"/>
    <dbReference type="InParanoid" id="A0A194RPM1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="27040" checksum="EF637628947E368B" modified="2016-10-05" version="1">MTLVCVTQMFTNIMKHFPEFWNGAGIILICALTLVKGNVIDINKNGCPLDYTIERLLEHEDCNKFYQCTIGELVEHTCPKDLLFNIEKNECDWPQNVICGDRVIPDKDEGNQDADGDANGGNCNPSEAPSICATEGSDDILIAHENCNQFYKCLQGVPVPLKCASNLLYNPNKEICDWPENVSCGDRIKPDCDFNDGNDEQVGDDGAEIDDEGNCNCDPGEAASICAAPDTDKSNVGILKRSIVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ60</accession>
    <name>A0A194RQ60_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ60"/>
    <dbReference type="InParanoid" id="A0A194RQ60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="137" mass="16230" checksum="CA0EACE2AEA30C5A" modified="2016-10-05" version="1">MDAFNKIKYNCHSKTNNSRARGKADQKFSDLNKSISDRTALLYGLWGNKDNDRDDDDDRRDPLGYNSKTSYYEKMKYQGSRDREEKRQIDRSDIGRQVKRWEDDLPKGWRRLARDREVWKNLGEAYVEGQPDKETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQP5</accession>
    <name>A0A194RQP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQP5"/>
    <dbReference type="InParanoid" id="A0A194RQP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="13789" checksum="8931B4359A9EBC2F" modified="2016-10-05" version="1">MKKCKENKKTTPPKPKSKPLDLCKNCTSKYCPGSTNLVSQKRSNITPKASKTSVGTKASKMSTSNKCNCTSYLDHAAMLDMIIDDNICSCGIFAQALRSNIHMNIGTLIHQEECSSATEDNVIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAX3</accession>
    <name>A0A0N0PAX3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAX3"/>
    <dbReference type="FunCoup" id="A0A0N0PAX3">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAX3"/>
    <dbReference type="InParanoid" id="A0A0N0PAX3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="372" mass="42788" checksum="8D4D8265D4E1B0E5" modified="2015-12-09" version="1">MAANILNCSKLASINPINLGLIEKVPGFVELLGVHIFGHGYRRSKFLVMPQRGFKWMQYCVRAFHYANSEDFGYDGVIGPVHWGERYQECRGKHQSPIDINVLRVKQVALPDITFIGFDDSIDDVHVTNNGHTVLIEVENEPHPRVSGGPLDGDYIFSQMHFHWGDNDTFGSEDKINHRSFPMELHMVFFKEEYKTPNDAVRHSDGLAVLAFFYELDRHQHPAYDDITSALSNVTEPHTSVVMNHPFSFLNILPYDLNRYFTYRGSLTTPPCSEVVIWLDFEQPVRLAHDQIEVFRELRSATGKIRHNFRPIQPIGDRVVFYNIDNKYFSYNEVDDPNEDIPKRKKGHNNSYGLVCSVYTVLSLIIINVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB07</accession>
    <name>A0A0N0PB07_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB07"/>
    <dbReference type="InParanoid" id="A0A0N0PB07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="44558" checksum="BC7C75B43C305712" modified="2015-12-09" version="1">MPHVNLDARPTTTNGTNGTDHPLRLQIPDKSNGTVTTNGALSPNSNGALSPPILDATPKKPPKAPPSRPILPMKKSKTLPINFEEKVPPKISTTIHSGKKVFVTKQLKELQTIKQNGPENGKLLVTRSPSPTYKKSMSIETGSIAELAKRHVLGTCGSILTSRSPSPSSYSSIRSSTSQYSTCSSNGTFVPLSRSSSMNSTLYDRTTPTPRRMYPQTCDNSNRVDLIELRSKEQSPVVFDANLSFVLGCNKQPIRQKFKPIAAHLEEGTSSNYLSSKIDNFLRRTDHVMDEWRRLGHKDESDRTIGRSKSATNIMIKGFTMFSRSGSRASSVCRSNRGISEDRTTVSELDELSEVGGELAEERAAAALASERADAEAAERLRVERDNRDLVANNQRLQQVSLYPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBJ0</accession>
    <name>A0A0N0PBJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metastasis suppressor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460936">
        <property type="protein sequence ID" value="KPJ10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBJ0"/>
    <dbReference type="STRING" id="76193.A0A0N0PBJ0"/>
    <dbReference type="KEGG" id="pmac:106715513"/>
    <dbReference type="InParanoid" id="A0A0N0PBJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="923" mass="100266" checksum="ECA22C0CDDA2C348" modified="2015-12-09" version="1">MDRLISPLCERAEEWRRGACGGALGREHARDCKRARAELRRRVQEAQRHARKARRAPPDAKRRADVSMQDVQERKQQLEEMEEKAVKAALIEERSRFCHFVTLLDPVVESEVAMLAEVGHLQEGSEQLLRHTSEPRTLPAASLQVICDVKSCYSGWAESESAPHSPSASSRLGSRKSSLTSISSLNSQCSDQQQGVSGSTVSCSTPISNSSGGTISAPGGESQRCLSQSGLRLSSVCSSDSGFRSQDTLQRHSLYTRNGSDNHSVSSECITPSKSAIDDDNTDDSHDMANAASATWPDLKDTAQFERAASAIMSGRSHTISSGDRVHPRATLSVHTFSSEGSGTLSRDGIYARPPLPTRCSSLERPSLPAKSVNANTGQQEIKPIKPSSLPPHLTKEMPQALYVNMSELATLAASRAQQQQQQQQQQQQQHGSEFPQQEKVCSESSASESSLESSSGYGSQGAFAAEEHAHQHQIHTDVDSEIVTLRRDSEVAAARENFSISLGSLEEAVRSLDEVNDTPAYATVSKKPAVPKRRPVSMAATVWSRRGSSSSLGKPPPPVRRSSSISRPQRPPYVQNNMASPQLCTDADNLPPPPAFLLQPDTDINPAHAGINVAETVKQLTELKHMPASPGLVRRTMQNQTTNQNQNSTTNSNQTQNQNQPSLSTFQQAKSNFNTSASGNLNPIYGQTGHRIMAYVENSIYVRKSSLNVSSSDLFRDANTGNIYGEGKGSPHGSSPSTPSYGETNSFSSFGPRVNNDSHYGQTGFKLQQEKKYSNSIYAAPAQLGATLSPLALRRSIAARSHSADRHAEQGGLIASLSAKLAPQLSPRTSRRTTVTPTTDNKGKGNLPSAVQPAFLDKLSATIQQQRRQLDSSRANNVRDLINAHAQPDPRTCHTSLMEQIKRGATLRRNKHCNDRSAPKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBW3</accession>
    <name>A0A0N0PBW3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04275</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBW3"/>
    <dbReference type="FunCoup" id="A0A0N0PBW3">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBW3"/>
    <dbReference type="InParanoid" id="A0A0N0PBW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="426" mass="48786" checksum="B7AA167B35C4284C" modified="2015-12-09" version="1">MTTPCLLLRDLDVIKNVMIKDFDLFADRGIEFSDEGLGVNLFHADGDRWRVLRNRFTPLFTSGKLKNMLRLMTECGDTFINYVDNICQKEPEQSMHIVFQQFTMASIAACAFGVDLDKDMIKTLERIDKLVFTVNYGIELDMMYPGILKKFNSSLFPKDVSTFFDNLTKSVIGQREGLPSNRKDFIDLILELRQQKTIEGAKRNENEDVKALELTDSIIAAQTFVFYVAGYETGASVLSYLFYELAKNPNIQDKLISEIDEVLKHYNGELNFECLSEMTYLSQVFDETLRKYPMGDLLQRNAKTDYAVPGTNVIIRKGQTVIVSAWGVHHDPKQYPNPDVFDPERFSPENVSNRHSCAYLAFGVGPRNCLGIRFAKLQSQVCIVKFLSTFRVEISKNTPLNFKYDPMRLFAFPIGGIHLNILRREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC53</accession>
    <name>A0A0N0PC53_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lymphocyte expansion molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC53"/>
    <dbReference type="KEGG" id="pmac:106713009"/>
    <dbReference type="InParanoid" id="A0A0N0PC53"/>
    <dbReference type="OrthoDB" id="6275292at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033557">
        <property type="entry name" value="CIMAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914:SF1">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40657" checksum="1FFF4A403743D100" modified="2015-12-09" version="1">MVTTKRLAAFGSGVKRFGKNTGHPKLDPNGLYISRPEGCDPCLYHPQDIDKVFDFNKHIKNRVDPWKYKSDLEEWSKNLGYRNQKVLDRKKWFDSLLGPAWHDVQDDKKYEPACNNVGFGRTPRFKHSTKSIPGPGTYYKHVPYKAPHGPHSEKQTFEMQEPCRFKDPAPKWSLAPNRYNIIDKDSIEEKPKKIVSLRGPYDLFTGKRDGTSIKNHFNRTKVSAASWPYSLKGCMETYKRSHYGEMNKTNRELPCRSRNTLVDLAMCIRNPGEPGPGQYDVERPRQFVQNAQGFNSSYDRPPGYRRAEVWPAVGRYHVRCIKYQVPGGGHRHAFLSKVPRTIGAVLPQPMNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDN2</accession>
    <name>A0A0N0PDN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase subunit 4 isoform 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460141">
        <property type="protein sequence ID" value="KPJ17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDN2"/>
    <dbReference type="STRING" id="76193.A0A0N0PDN2"/>
    <dbReference type="InParanoid" id="A0A0N0PDN2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="123"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="766" mass="87160" checksum="88A904126E565D2E" modified="2015-12-09" version="1">MANYLLRRAIIDAIRVPVGTRASSELAKIGNREWVGYGYNGQPTYVDRPDFPLPAVRFRPDTPDVKVLREKEKGDWRKLTLEEKKALYRASFCQTFAEFQAPTGEWKGVVGWSLMFISLSLWIYMGMKLFVYSPLPASFSEEAQKAQLKRMLDLKVNPIDGLSSKWDYENNRWKAWNNRFYRENPAFLAVRVGSSFYNSGGERIAILEIYFHPDYNPKNLWNNICVLRLERHIKFLKTNVKSVKKIAIDKNPWNLPVNTPGITIIGWGAKSTSNKVGDPFHNILSFSHLDVYPTRECQEVYSKEYVTKQNFCGGFFSKGGGACNRDVGAPGIIGGTLVGVVSFGSPVCGTPDAPTVFTKVGYYYRWIETIMDMHVPHSKKKATTKYTLDPYEQYLTTTPATTTFKIEPLLGAKPPSVLDDTEYEDNENTLRTLDDKLFQEFLETMFGSNEVQKYEDVIHQDANALRDTKDKLTVKSKIEVTTTEISVQPVTYAYDSEVESPRTQIIPVDTYEMTDKVPVTENIEVEESYHSKYVSDSKHKSKIERNKPKDIVYEIPVTTTEEAQEIYLELAPDSGRDSEQSNDNQEQSIDNQEQIVDQSEAKSEGVSKESSETSSADISDIPGEEVIAELLDEIDFNQILREVSTDATISKTSRSSYATKLQRHRFLSTTTESINTKNSYNIPRELKSADGVVQSGNNSLLTLLYISDGERKRNVNKYNLNVEISRRKNINPRHYKRDNALNDLGPKTELYRIISRVIEAAMSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE16</accession>
    <name>A0A0N0PE16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ERC protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459992">
        <property type="protein sequence ID" value="KPJ18584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE16"/>
    <dbReference type="STRING" id="76193.A0A0N0PE16"/>
    <dbReference type="InParanoid" id="A0A0N0PE16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="8614" checksum="6EBC03E4741AEA60" modified="2015-12-09" version="1">MHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLNQENQVRHFMNTSAYYLIPFNLLITIYKFPFYSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFJ0</accession>
    <name>A0A0N0PFJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035543">
        <property type="protein sequence ID" value="KPJ21294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFJ0"/>
    <dbReference type="STRING" id="76193.A0A0N0PFJ0"/>
    <dbReference type="InParanoid" id="A0A0N0PFJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11684" checksum="DA6FFA3F578CAFF7" modified="2015-12-09" version="1">MERTKEELIALGYDDFDNVDNSEDEQSSAGSAEDTTHIGDDICLEDLTDLSDANDEDVMETKRETRKRGKSFTIKKNMKGETQLHVVSTKSHNFLTHLPPPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFR9</accession>
    <name>A0A0N0PFR9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01056151">
        <property type="protein sequence ID" value="KPJ21564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFR9"/>
    <dbReference type="STRING" id="76193.A0A0N0PFR9"/>
    <dbReference type="KEGG" id="pmac:106707424"/>
    <dbReference type="InParanoid" id="A0A0N0PFR9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ21564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="167" mass="18350" checksum="AB9F395FBCEF0C56" modified="2015-12-09" version="1">MVMDRLVVAGVDFSSIEALSGAAQQHGSVWWAKGSETKLGSLSPDEFLHTQLATSFVVDSPVWMDSSTTADCRALEEAVGGPEELAKITGSTAYERFTGSQIRKMFRTRERAYQATERISLVSSFACSLFLGKIAPIDFSDGSGMNLLDIKTKKWCEKALKVRKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA92</accession>
    <name>A0A0N1IA92_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3 8">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ459946">
        <property type="protein sequence ID" value="KPJ19136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA92"/>
    <dbReference type="FunCoup" id="A0A0N1IA92">
        <property type="interactions" value="1891"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IA92"/>
    <dbReference type="InParanoid" id="A0A0N1IA92"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ19136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="278" mass="32468" checksum="83C30DB4B6827250" modified="2015-12-09" version="1">MSDTNSENDVLGPPSLKKIKNNEQNENGVDDIQLELKDFIPVKILNNNTNRKTVCIQGTYKDKTGVALVLLEKNAFKEEDLDNKGYFSEDTKLRTFFKNDIYGNFECFPLPEINEGKSEQDRVIYDNKCEREGFVLVPDLKWDGLTKETLYLLAIVRQRGIKSLRDLNETHLPLLKRVRDEGKKTIYSKYKVSGSQLRVYLHYQPSFYHLHIHFTYLRHEAPGIYAEKSHLLDTVINNIEMMGNYYKKATLPFTIREMDTIFNVYETNGHVERIKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB92</accession>
    <name>A0A0N1IB92_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_01981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB92"/>
    <dbReference type="FunCoup" id="A0A0N1IB92">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IB92"/>
    <dbReference type="InParanoid" id="A0A0N1IB92"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="110"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="31841" checksum="7D1FA9F57A704223" modified="2015-12-09" version="1">MCVEQRPYHVGISTEVGLRSTDDSAAVEVRGYFRLPDLLRFLNTLRLVVVGHITSSIKMKLSLVALSCLLLAAANAYEPIELEYHENVGIPKAEAIRQAELAADFDGSRIVGGSTVNSLGEWPFIGGLVITLTDGRTSVCGSSLLSATKLVTAAHCWRTGNAQARQFTVVLGSLRLFSGGTRVNTNRVEMHGSYNMNTLANDIAIITINRVNLNNNINTIALASGNNNYAGTWARAAGFGLTRDDNINTIALASGNNNYAGTWARAAGFGLTRDGEIFNSNSTRFTHLLLIFYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBD7</accession>
    <name>A0A0N1IBD7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460127">
        <property type="protein sequence ID" value="KPJ17579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBD7"/>
    <dbReference type="InParanoid" id="A0A0N1IBD7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11096" checksum="FBB81854EA163EB4" modified="2015-12-09" version="1">MPKSKSRDVKIVHSDKRIAKLDDESLRKLTDSDGPCNECICNLIDPPKRPFDLRNAIRSAFDSLQMYTDSTAKSLGITSSSNLAGPSAKDKEKEKAKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDW9</accession>
    <name>A0A0N1IDW9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDK-activating kinase assembly factor MAT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CDK7/cyclin-H assembly factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Menage a trois</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RING finger protein MAT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461053">
        <property type="protein sequence ID" value="KPJ09937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDW9"/>
    <dbReference type="FunCoup" id="A0A0N1IDW9">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDW9"/>
    <dbReference type="KEGG" id="pmac:106716327"/>
    <dbReference type="InParanoid" id="A0A0N1IDW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16517">
        <property type="entry name" value="RING-HC_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="311" mass="35562" checksum="C56E71C465F394AD" modified="2015-12-09" version="1">MDDQACPRCKTTKYRNPSLKLMVNVCGHALCESCVDLLFLKGSGSCPDCNVPLRRSNFRVQLFEDSMVEKEIDIRKRVLKDYNKKEEDFATLREYNDYLEEIETIVYNLCNNIDVVGTNKRIEQYKKDNKELIMKNKVKIGREEIELEEILETEKQMEELRRAEISRLEQEAKKQKIREKEALIDELMFAEGDAKEILNTFAQNIAKKEEIDVIPIIPKVTQFSTGVKFSRGSGSQQGVPILEEGPLYKYEAPVIPDRCGPDPPSIQNIISKGYLQHVRAENETEKAGGYTSTLPCLRALQDAMAGLYHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEQ3</accession>
    <name>A0A0N1IEQ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_01405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEQ3"/>
    <dbReference type="FunCoup" id="A0A0N1IEQ3">
        <property type="interactions" value="1800"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IEQ3"/>
    <dbReference type="InParanoid" id="A0A0N1IEQ3"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000008">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000013">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="273"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ14590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="727" mass="79936" checksum="2F80294E5B778B6A" modified="2015-12-09" version="1">MHTASAEGQYRGTNGSTHGRDKVAILDAGSQYGKVIDRRVRELCVESDILPLDTPAYHLKEAGYRAIIISGGPNSVYAEDAPRYDADIFKIGLPVIDRRVRELCVESDILPLDTPAYHLKEAGYRAIIISGGPNSVYAEDAPRYDADIFKIGLPVLGICYGMQMLNKEFGGSVLRKEAREDGQYEVEVETTCPLFNRLEKLQPVLLTHGDSVQKVGERFRVGAQSSNHLIAAIYNEQMRLYGVQFHPEVDLTPKGKQMLSNFLFDIAGLTRTFTLRSRREACVQYIRDTVGDQKVLVLVSGGVDSTVCAALLRTALREDQVIALHIDNGFMRKNESVKVERSLRELGVRLHVINAAHQVRALGAELGLPSALVERHPFPGPGLAVRVLCQEEPYAERDFSETQVIVKIMVEYASMCVKSHALLGRVAGATTPAEQAELKRISSKSPVAATLLPVRSVFGLPSALVDRHPFPGPGLAVRVLCQEEPYAERDFSETQVIVKIMVEYASMCVKSHALLGRVAGATTPAEQAELKRISSKSPVAATLLPVRSVGVQGDARTYSYVVALSTERYPPDWQDMQYLARIIPRVCHNVNRVCYAFGGIIKEQVTDITPTFLTQHVISTLRQADDLATQVLTSSGCAGRIAQMPVVLLPVHLDRDAALRAPSCQRSLVLRPFLTGDFMTGVAALPGSDAMPQDVVDRMRKELMSLPGISRVLYDLTPKPPATTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IER1</accession>
    <name>A0A0N1IER1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Syntaxin-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IER1"/>
    <dbReference type="FunCoup" id="A0A0N1IER1">
        <property type="interactions" value="1701"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IER1"/>
    <dbReference type="KEGG" id="pmac:106714677"/>
    <dbReference type="InParanoid" id="A0A0N1IER1"/>
    <dbReference type="OMA" id="FVFQCRE"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15850">
        <property type="entry name" value="SNARE_syntaxin18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000015">
        <property type="entry name" value="Syntaxin-18, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="327" mass="37986" checksum="EF33F7C02DC4A67D" modified="2015-12-09" version="1">MDITPLFKACIKTVKTRNKTFGIQSPSNEDKQRLHRTKPKSEFTLTAQDITCQITLLRDFLLEHRSRYLSFFNNETGDEMSDAERDQIDTGAQRIINTCSHLLKEFRNDNRKVAVSPQMRDFMDAVIDLIDTYLKAVCKIHSELKALRVKRALDIRKLSRLEPPTTKSSVRNRFNPKKTEENIEEKVFNSTESDETDLLKTKMDLSESEMAIMSDEGELDSEELQMFESENVQLLNELNSMTEEVKQIESKVLHIAELQEIFTEKVLQQEQDIDRISNTVVGATENVKDANEQIKQAIQRNAGLRVYILFFLLVMSFTLLFLDWYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF04</accession>
    <name>A0A0N1IF04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF04"/>
    <dbReference type="InParanoid" id="A0A0N1IF04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="7926" checksum="A78E081DAB2745FC" modified="2015-12-09" version="1">MRRGKALLESSRQGSVDGNSNVANDKELVHKCHSDPGGGRALGAIPRTYRHRSASGALRKCVLTLDGYSYVIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGQ0</accession>
    <name>A0A0N1IGQ0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460419">
        <property type="protein sequence ID" value="KPJ14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGQ0"/>
    <dbReference type="STRING" id="76193.A0A0N1IGQ0"/>
    <dbReference type="KEGG" id="pmac:106711026"/>
    <dbReference type="InParanoid" id="A0A0N1IGQ0"/>
    <dbReference type="OMA" id="PDNIVYG"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000089">
        <property type="entry name" value="Tubulin, beta 6 class V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="448" mass="50044" checksum="204734D076E3A9D9" modified="2015-12-09" version="1">MREIVHIQVGRCGNQIGSKFWEVISDEHGIDPAGCYTGDSELQLERVNVYYTEAAAAKFVPRAVLVDLEPGTMDCILAGPHGALFRPDNIVYGMTGAGNNWAKGHFTEGAELLEPALDVVRKEAEGCDCLQGFQLVHSLGGGTGSGLGTLLLSNLREEYPDRIVMTFSVVPSPKVSDTVVEPYNATLSLNQLIENTDQSFCIDNEALYDICFRTLKLPMPTYGDLNHLVSMMMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALSVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQTKNKDYFVGWIPNNVKTAVCDIPPRGLKMSGTFIGNTTAIQELFKRISEQFAVMFRRKAFVHWYTGEGMDESDFAEADNNMSDLISEYQQYQDATINDQEFEEEETTQNDDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGW4</accession>
    <name>A0A0N1IGW4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGW4"/>
    <dbReference type="FunCoup" id="A0A0N1IGW4">
        <property type="interactions" value="27"/>
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    <dbReference type="STRING" id="76193.A0A0N1IGW4"/>
    <dbReference type="InParanoid" id="A0A0N1IGW4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF457">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="153"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="405" mass="43321" checksum="832D986B5CDC7072" modified="2015-12-09" version="1">MDDADVPAKGNIFGKVVPARYVLAVLGSIAMAIVYGLKVNLSVAMVGMLNHTSIRLASNPDRELLELGNYTPPSDVECQPTSGGSHTSEMDGPFEWSSEIQGIILSCYFWGYFVSQIPGARVAELFSAKWVMFFSVTINVVCTLLTPVMAEAHYIAVVIMRIGEGIGGGVTFPAMHVLLSKWAPPAERSVMAALVYAGTSLGTVISMLMAGMLTASLGARVAELFSAKWVMFFSVTINVVCTLLTPVMAEAHYIAVVIMRIGEGIGGGVTFPAMHVLLSKWAPPAERSVMAALVYAGTSLGTVISMLMAGMLTASLGTLMALTNTVATVPGIVVPIFVGVLTHGNQTISAWRIIFFVTIGLYIIEIIVYTLFGSGEQQPWNNPPENHDEEGAKRPLNTETEKTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II92</accession>
    <name>A0A0N1II92_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460324">
        <property type="protein sequence ID" value="KPJ15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II92"/>
    <dbReference type="FunCoup" id="A0A0N1II92">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1II92"/>
    <dbReference type="KEGG" id="pmac:106709950"/>
    <dbReference type="InParanoid" id="A0A0N1II92"/>
    <dbReference type="OMA" id="FDHRGKM"/>
    <dbReference type="OrthoDB" id="440745at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF7">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="425" mass="49536" checksum="599DB48E56720F00" modified="2015-12-09" version="1">MQSVVTYEKPLPHLSLADWDARLYGLQVTADTRRADAFDLRHSARQLRNETKIKTDWDIYHNNNRLRARVYEIEQWKSTLQELLDRLDREMNALKEEKASTERELEQLNVPLLICSECLSNRDGRRSTELTYDLADTELKKELCVTESNKKLLTDRCQSAWEKINKLEVIKFKLQLDLNDKNEALQIDKDMLNLDKDCANITYKSDPLKTPKRMITYEQWLEKCEATKKMAEDGLQDTLSLRESLFVARERARNALRAQTDVTNYMMRKRIYDTQRARNELEWQKMKMEENMDKLAAELKIMGEQFSDKINALKVAETRLETRGYRPGIELAADEADIGLKEEVQNLKETIRQLQEKLDCAKATYNALEAASIKIALDLADKEHSLETDIRALEMRSALEPKRLQGTEKNLVLARVSDEVPKTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKI2</accession>
    <name>A0A0N1IKI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01002513">
        <property type="protein sequence ID" value="KPJ20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKI2"/>
    <dbReference type="STRING" id="76193.A0A0N1IKI2"/>
    <dbReference type="InParanoid" id="A0A0N1IKI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="7086" checksum="D277A267EAEF3815" modified="2015-12-09" version="1">MGKIEGKRPRGRRPMRWTDQVRTTLDSSIHNAIHSAENRTEWRTTLREMVKRRGRDPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INI3</accession>
    <name>A0A0N1INI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INI3"/>
    <dbReference type="InParanoid" id="A0A0N1INI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="40" mass="4635" checksum="DBC5AD0D56F511DF" modified="2015-12-09" version="1">MRHEANSAAWTAPGEVWEYVSQLVSSYHDQHDCQVTQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPG4</accession>
    <name>A0A0N1IPG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPG4"/>
    <dbReference type="FunCoup" id="A0A0N1IPG4">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IPG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155:SF1">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="35165" checksum="692E840D5B7AC1A4" modified="2015-12-09" version="1">MAHKVKSNHYVATHRSGMDSPSSGGYLHRGSSRDENDSHRAPSERTLSEYTMTFRRVSASSSNVCKSANAYVLYPLYIGAGAIDKADTIDERTRSPSGGGSGEHRNGRRHQTGGSPRADSDVYVTSAAYRPPSEISRQSRAPRSVYSYRSAVAPSVASTHRSKVSRKAGVKVETMAAPNPFCPNVKGMCCLMLLLNLGLILVTLGFVIVLQFFEPLFVWILGIVFLIFGFITLVGSLIYCVVLCRENPYPRYPDDFYWTHHWSKTIGPSEIHYSASEKPYRQNGHSDRYNKYNGKYSDKESAKGYSDRESKLSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPS8</accession>
    <name>A0A0N1IPS8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative adenosylhomocysteinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460296">
        <property type="protein sequence ID" value="KPJ16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPS8"/>
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        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPS8"/>
    <dbReference type="InParanoid" id="A0A0N1IPS8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase"/>
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    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="421"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="517" mass="56531" checksum="DB2663AB624F5E70" modified="2015-12-09" version="1">MATTGILKNTTREENVTLQKRHSIISGKSDFWSSSDEEEGVQPHEKAIAAGQPNPPYCVRNVEQHAFGRREIEIAEQEMPGIMALRARAKDDKPLKDAKIVGCTHINAQTAVLIETLTALGATVRWAACNIYSTQNEVAAALAHAGFAIFAWRGQSEEAFWWCIDQCCTPTAAWQPNMILDDGGDATHLMLKKHAPAFKQIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKTKFDNLYSCRESIIDALKRSTDIMFGGKQSVVCGYGEVGKGCCQALKALGCVVYVTEIDPICALQAAMDGFRVVKLTEVIRQVDIVITATGNKGVVTRDHMERMKNGCVVCNMGHSNTEVDVHALRTPDLLWERVRSQVDHIIWPNGKRIVLLAEGRLANLCCSSLPSFVVSVTAATQALALIELYNAPQHRYKVAHETDCAKFYQCSNGHDFEMTCGPGTVFDENLQVCNWPSAVDCKKKTSPKKPAKSQPPKKDSKPPSKTPPAKKPAAPKAAAKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ53</accession>
    <name>A0A0N1IQ53_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIT domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459986">
        <property type="protein sequence ID" value="KPJ18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ53"/>
    <dbReference type="FunCoup" id="A0A0N1IQ53">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ53"/>
    <dbReference type="KEGG" id="pmac:106720838"/>
    <dbReference type="InParanoid" id="A0A0N1IQ53"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="240" mass="28262" checksum="8229D5ECB2CF86F4" modified="2015-12-09" version="1">MNIDSTAVNILKRGVEFDTKKRYTEALVCYQEGLQILVDRMKGECDDDVKKYLKVKIEEYMDRAEIIKKLVLKQKETGQFHEQVRIENNSTGHSYKTLFGRFLDKDVQYVIVEDPYIRSFHQCQNFLRLSELLVKSCSNLRRIELVTTKDNKSEGDQTKWFTELRNDLARYEVHFIVNYSDTLHDRQIILSSGWIIKIGRGLDFFKAPENKFCLGVYDLDLRQCHETVVDIVHSKHVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQF8</accession>
    <name>A0A0N1IQF8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQF8"/>
    <dbReference type="InParanoid" id="A0A0N1IQF8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8616" checksum="0678237CA47B1F16" modified="2015-12-09" version="1">MFYMKSHPKSTLIPYPVQLFGTIQWRKEPVIIAYILQVLNTSMALRLVETLRSVTKVHLARVPMDNSIDLGDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQG7</accession>
    <name>A0A0N1IQG7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mushroom body large-type Kenyon cell-specific protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459687">
        <property type="protein sequence ID" value="KPJ20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQG7"/>
    <dbReference type="FunCoup" id="A0A0N1IQG7">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IQG7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000019">
        <property type="entry name" value="Ligand-dependent corepressor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="8">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="730" mass="79760" checksum="352884923FF13B1D" modified="2015-12-09" version="1">MFAKNKIGQINPTEFAQRLERVAEELMGRRKWKLYQDALIPKRSDGEQSSDEDTTPSTDPPPALKIKTIEEINAPDETRAGDDTRAGLESRAGDETRAREEGGVKTGRPETILESLIKRPATQPKLELPEEPADWKPPEKCYFCVDGAEQPAADTRPAPTSPASESDSSSVSGARSPAAAPPLLQQMLQLQLQAQTPQAIAQFQQMLAALAALGSGLVPPPLPQAWLIQRLAQNRQQPDRLAECDKPPAPTSSPISAEQPLDLSAKSTSSTSGTPPPDHNNLDNSRLKRAVSENANNASRRTYSEEELQSALRDIQSGRLGTRRAAALYRIPRSTLRNKINKCGIPTDPTHDSDPDSEPERTDSPPSVILKIPTFPPPDEKSPSPATPVTPITPLIPPPQAPLNQASQLLLPSVFADPPSTQHLFTSLSDVIAKSISQKFQQPLERPSQPDLPFMRAPDRHVSVIKTPPDNQRNYPAPSNSRAATNNNGQPATGGKGTRPKRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKERHLMRPRKREPKPQQEAKPQPKPPPKPPTKPFTNGLNGPEAYPSGYPFWAGGFAPPPAPDLYASHMMRRLRDEAPPANGSFLEGIIRSSLERPLIQRLAEPRAPMPTSEAPSLLRRLAGEPDEPPPARRPRIDSSDRQLAAEMREAVQRLRADKLRPRNGTPTPPAGSPPPPPAATTAPPDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFH6</accession>
    <name>A0A0N1PFH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein prickle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461184">
        <property type="protein sequence ID" value="KPJ07518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFH6"/>
    <dbReference type="FunCoup" id="A0A0N1PFH6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFH6"/>
    <dbReference type="InParanoid" id="A0A0N1PFH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000022">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033727">
        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ07518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="46324" checksum="39B11FEC6C372756" modified="2015-12-09" version="1">MVFTYVQCEETMSAGDMCVTAARAGPAARWHPGCFVCTSCQELLVDLVYFWRDGRLYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMKHFACAECARQLGGQRYIMREARPYCLPCFDGRFAEYCDACGEPVGVDQGQMSHEGQHWHATERCFACHTCRASLLGRPFLPRRGAIYCSIACSRGEPPTPSDSSGPGPRPPRVPRPRRAPSPSLRSPNSPRASPQRETSPPPDADSEPSASLAPDSPAPQPPPPPHACLSLDRALADLRLEQSITEQNQIQPTPTSEENEERADWRPPPPVETQALVAQGHASSMPELTGGERRRARGGRTVRFCGDDNRAFEPDEPARRERAREEDASSYCSTCSSSSSSTESYSLPTRRAYGGVRISYVPNDAVACARRERRRKSAGQDKNCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFW8</accession>
    <name>A0A0N1PFW8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_05400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFW8"/>
    <dbReference type="FunCoup" id="A0A0N1PFW8">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFW8"/>
    <dbReference type="KEGG" id="pmac:106712997"/>
    <dbReference type="InParanoid" id="A0A0N1PFW8"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12460" checksum="63691E9D629CB2EB" modified="2015-12-09" version="1">MLFCPTCANILIVEERPESGLRYACNTCPYVYDIKKKVSYRTFPKLKELDYIMGGAAAWENVDSTDAVCPKCGHGRAYFMQLQTRSADEPMTTFYRCCNHECAHNWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHA5</accession>
    <name>A0A0N1PHA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHA5"/>
    <dbReference type="InParanoid" id="A0A0N1PHA5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="236" mass="27348" checksum="9EBFAFC22A31F674" modified="2015-12-09" version="1">MVKSASLKSALETLPQLAGVVVMAGGTTAANTDAKEQRDEEIHLVTTDQLRKMYKLFFLFLLFVAVDSNRCHKDGSCRHRHNQHRPARYNNRHFEKIFQDISWSVINMDRKYQAVCSNSSEQQIREYYGADTYTLKYFLKEYSEDNVTIKVQHRVMYLKAENNNVTVFKDIRILPKIVDAKTGQYFKQDDDLLIQFSYITNPKTENVVTCSGDINEEIQKLVKVAISEEDLRMSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHJ1</accession>
    <name>A0A0N1PHJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisome proliferator-activated receptor gamma coactivator-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_01299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460777">
        <property type="protein sequence ID" value="KPJ12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHJ1"/>
    <dbReference type="InParanoid" id="A0A0N1PHJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="1473"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1250"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1297"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1334"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1410"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1609" mass="182322" checksum="8E53F8251EB428EE" modified="2015-12-09" version="1">MESHILNMYHQPRFRSIGHKLIRSTSESLSSEGSCQQNSPEYTQAQQTNQYEEESNEGEFWQPQENQGQVWNDRNNENCVTEQSSQDSSSEEEDYVVQDNEGLDRTALDVSHIEQLSIESVDNCSLVEGADYDVIQVYAVHPDFDLEASSDEDEQNDFCIQENSDESDSEEKNVNNVQEDTNESSDDNDDSNSETSDISHDGLGINLDTPVVSNVDEYFIKDTKEKNILDVKDEPVVNDVDEYFIKDTKHASTPIAPIAELEPVPSIPSIDDLLIKKQSTASAFHIPKVTPIITDIFEVSQNVKDEVSQDATEGQDQPDEVPIAETVLDMRGNQMPRMFRNVDDIKKFLFSDISDTKYKHAQKSCSVPHSPMHSICMDIDAKTCMSFEDLNLDLTDITFDSDKDKSANSFKSDDIPRTLTDEDVNSFLITNKTPQISTMKTEDDFNPQDMEIDGSIETSIDNIGNIPPISLARNNSSTPIPNVLEFCIEKSPVKKENELKVEIDDFVDVESCNETVNPIFEESNVKSRFEPINIENNIKAKKSTIKMNEQKVKPSNALTNGMRLQDAGVQLNKNKMRKIMMPTSINTAVRRSPSPVRSDHDYCSSKKRYNLGLKQGQSLLKPEVLSSNNRILNSRHRSCKNKKIVYHLSSDEESDKCNSNKTKKATNLRSSDDNDVKLRKSVVKQPVKATVPSTCRKKTSPVRSAPNDTSFGKGNDSVMVKNACKASDNPSSQSSNGSIKLTIKNKSEVIIKNCDDIKDYKKDKKNEKSKSINIVNDKSNVKNNAVKVIETVDSSKNKIVNNVDVQNNTRVSVKEEHSKPEHFYAALFSNKQDVLMPNTVDIKTEKRSHEEDLTRFNSPEDIITKIEMEQPQKKKKLNLQEYKLRRGASSNNSSATVSPESIFPDMPIPDISKIVKSTTSQTPANTGLNCAPKADLEAPKKIFDPIREASRKILMNNKKQKAEAIRKRDEDIVMSKIPKVENLELQPLISEAEMMKIVGMATDILPAPRVVEKIPPSSDYDEIVVVSIGTNTDEEVFKKIELEVENEKKKSQPHPTDIKSTINFKIKKPDHVLKHNIFDTVQKDKSPTEENKIIDIKLNQDRYKDITATLKSVEKQVETKISSNSLFASIQDVVMKKAPEVTILASTNGEHKSKSNSSIEKKNSFKAPKTLIIREYDVQAEHGEDKIILHLEKQRTKPSALSIAIQTNPVLKIVNKSKMATPEKIAIPKEEPSTNRKRNDSDMSMSSESSPDRTKMDNKIAKVDEKSIKLKPEKRESSAQTKEKRSNSRDRYDFKYRRSRSTSRGHRRKRSPSRNRSRSRSRYRRYRRSDSPYRRKRRSRTRSPYRKRRSPTPRREYRQRSRSRSKHAEPKRSKSPVKRTRPSPQYESNTVDKKTLISLTPPLIRKPTVSESSESSSSSSSSSSSSSSSSEESVKSRGSSTSFRKEKTYTTNNYRRSYSSEDGENNTPVEERRIVFVGKLEKDLSKAALRALFSKFGPITEVRIHTKDDGSRYGFVTYRKSRDAWSAVEAAASFPQYDVGFGGRRAFCRQTYSDLDGLEAKYSESAFLGQAALPARRNDDMSFEQMLLDVKKKLNQRKGDKKRHDESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIH4</accession>
    <name>A0A0N1PIH4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="6">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIH4"/>
    <dbReference type="STRING" id="76193.A0A0N1PIH4"/>
    <dbReference type="InParanoid" id="A0A0N1PIH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="391" mass="44978" checksum="97497AA0600429C7" modified="2015-12-09" version="1">MTENTSRSRNISFEQLKSLIDFMGQHIEFATGNCRTLEARHASKRLWDELTKTLNNSRTGTKKTSDGWSKKIENGEQQEEPDDWLRYGNPWEKARPEYMLPVNFYGRVVDTPEGKKWVDTQNTSRSRNISFEQLKSLIDFMGQHIEFATGNCRTLEARHASKRLWDELTKTLNNSRTGTKKTSDGWSKYWSDFKNKLKNKISILNKRQRSTSASKKGITPLSKLEKRALVILGPYFERKKARRKCEFSNKAISSQMPPEIKLEAYQDDVFSEFSKAQSDTSDRLSDGDGVEECMDINNEFDEDSDQNLNEPLIQSLYPKWLIQVEKKRAEAELIRAKAEEHRASVAAKSAEAMLLQAEALRHMSEAATTQAEAMTRIAIALENRNRDNMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJV9</accession>
    <name>A0A0N1PJV9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit CCDC47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052646">
        <property type="protein sequence ID" value="KPJ21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJV9"/>
    <dbReference type="STRING" id="76193.A0A0N1PJV9"/>
    <dbReference type="InParanoid" id="A0A0N1PJV9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="14163" checksum="5573357C76CF55F9" modified="2015-12-09" version="1" fragment="single">LSQCYLQFKRQDLVHVVMDLGRPSPDTLLVRVELGKDDCDPFVLCVAQKKVATRLAKEMQDLSVFCPERRPGDKHGLPVSMNVLSECAEATAGVLDSRLCGAITQYQKHVQYIHISDRYCGPKLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK92</accession>
    <name>A0A0N1PK92_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459939">
        <property type="protein sequence ID" value="KPJ19190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK92"/>
    <dbReference type="InParanoid" id="A0A0N1PK92"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="39" mass="4608" checksum="50A61E3961A580BE" modified="2015-12-09" version="1">MIQGQIMVSDTEEEPSDSTGRTKRRRTYAWRKRDLAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKK8</accession>
    <name>A0A194QKK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKK8"/>
    <dbReference type="FunCoup" id="A0A194QKK8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QKK8"/>
    <dbReference type="InParanoid" id="A0A194QKK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="9532" checksum="2D8C7F0F25558B55" modified="2016-10-05" version="1">MFLQAEDGSLSIPFRTPNEAIIAYEIIKVDKDLKGNKVKRYVTLNNTELAINFEGTDTKKLRVAVNSTFKNLLLIIKTLSEFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLL8</accession>
    <name>A0A194QLL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein Mohawk</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="76193.A0A194QLL8"/>
    <dbReference type="KEGG" id="pmac:106719898"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0009887">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="homeodomain"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN MOHAWK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="277" mass="32204" checksum="591FE9846A35224D" modified="2016-10-05" version="1">MTLIQRDQEAKEANMDGSPSKEDSGKSLRPVRNRRYTRRSLVAGQRPQKRLFTPEIKRYLKDWLVRRRDNPYPNREEKKYLSRETGLTYIQICNWFANWRRKLKNVNADRNQQTWGHLIRTYNDRAQGNVEQFSICSDDSIWSEPEPHPDDNLDIDARLESSPESNEDYNHPDTDSSLSTEKCESFNNNSNEIDHMSGKIENSKNITSPLLLSKWLESAARFQPSETNYSWWGEGRRRKIDSKSQTLVNSLRHDRDEVEAAVALTALASATTRVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM78</accession>
    <name>A0A194QM78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM78"/>
    <dbReference type="STRING" id="76193.A0A194QM78"/>
    <dbReference type="InParanoid" id="A0A194QM78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="7684" checksum="37A5BADE0B16A7B6" modified="2016-10-05" version="1">MEEVRISDWPEPPGSHAWLPAYGFQHDLLDKDDFFGSNGEACSQTSPPSPVPGPKGHFLSGGRALRRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMX8</accession>
    <name>A0A194QMX8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Acylglycerol kinase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.1.107</ecNumber>
            <ecNumber evidence="22">2.7.1.138</ecNumber>
            <ecNumber evidence="23">2.7.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Multiple substrate lipid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">RR48_11376</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">Ya'a_city_454_Pm</strain>
            <tissue evidence="31">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:34071"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:43329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41079"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43316"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:78209"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-(hexanoyl)sphing-4-enine + ATP = N-hexanoylsphing-4-enine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63867"/>
            <dbReference type="ChEBI" id="CHEBI:82959"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:43313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33747"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33748"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64982"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:39848"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a monoacylglycerol + ATP = a monoacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19293"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:19294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57674"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:17930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the AGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="5"/>
    <dbReference type="EC" id="2.7.1.138" evidence="22"/>
    <dbReference type="EC" id="2.7.1.94" evidence="23"/>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMX8"/>
    <dbReference type="FunCoup" id="A0A194QMX8">
        <property type="interactions" value="878"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMX8"/>
    <dbReference type="KEGG" id="pmac:106719523"/>
    <dbReference type="InParanoid" id="A0A194QMX8"/>
    <dbReference type="OrthoDB" id="9979394at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047620">
        <property type="term" value="F:acylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045579">
        <property type="entry name" value="AGK_C"/>
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        <property type="entry name" value="ATP-NAD_kinase_N"/>
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        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19712">
        <property type="entry name" value="AGK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="30">
        <location>
            <begin position="61"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024505"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024512"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048663"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KPJ06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="46698" checksum="7218494A3A3BCC5D" modified="2016-10-05" version="1">MERLIKFSKTIRNNWKKSVVGVVALYYGAAKIKEKYEINLLMRAACREAVKYGDSLIPMERNPTLVTVILNPVANKRKAKRDFEKYCEPLLHLAGLQVDVIQTTSEGNAKEIVETLRGTEAIIVAGGDGTFSETVTGLLRRNDGANQFPIGILPLGRTNSFGNSLFEGGKGVDRVKQLIEASMAIIKGDTEWKDAMKIEPMVHEEEAPSRPIYAMTSLEWGAFRDTMAKRDKYWFYGPLRDYASYIFNGYKESLNWNCSGVIKYTPPCAGCNNCIQKKPEVKRKWSFFMPSAPETATATVVNPECAMLQELCFKTSNLRIRPQKFGQSEIPSLSVVLGKNKYSYSEFVSEGWQRIKGIDENNKSIAARTVELLPNESGPDVIIDIDREEFEVKPVKITLLPHIVKVFCNNNKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP25</accession>
    <name>A0A194QP25_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP25"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
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        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="138" mass="15379" checksum="A94F7BF1788ED6C9" modified="2016-10-05" version="1">MPLEDALQLLSRNFQEVQQGGSAGREAVYALLGQLADGRSLTVLQYDKVIEYLQDRKEHQIKIELGEPMTTTTNSKAQNELQQRILSILNEKKVLPPKDPSPVPAPAPVAPSSQDVQNKFLNDPTLRKALNSILQKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPT8</accession>
    <name>A0A194QPT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPT8"/>
    <dbReference type="InParanoid" id="A0A194QPT8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="525" mass="58038" checksum="3B18176AB230E966" modified="2016-10-05" version="1">MTSQKEDSDVIDVCDEKPDKPERRDSKDLTELPPSGTSLHKRRRGEAPASLSVRAPQTPSETDGSSPYTGAPTLEEYWRLSDGSPDAEALCESMLQRLKDRDDPLSKRGKELALRTKDTLEALDQLEKLLELLDQFVTLKEHNARLLKRLRDVNHLKKLHEAHKRIDQESERLKEEGRELELINEALDAELECEYGQAIFDSMMAGGRSMKRTGSKVKGHGRFGSSLLRKQRSRSAGGEESDASPATPIRRRSDLVFSKEVEKSKVSKWTRVKAAFRWEKAQWPPSTYGGAAAVAAGAMVGAVALAGSSPYTLAQPEPRDSASLTPGSALSLTPNSSCEELRIDGGNCRKSVVLRCDDQDSAFLQAPMQDDSSTSPSPNKLHKSPWGKMRDIIQTHRESVKKKSRGKSSGEVLPARRRSLSDAGDSDAPPALTITIPSSEELESEPSHPVLRKQRSLELGARPQQRPPRRSVSKWAQVKRAFLSSASASVPSSPSRHSAFFTDAAKARSDVARAFYRYRPPLNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ73</accession>
    <name>A0A194QQ73_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ73"/>
    <dbReference type="InParanoid" id="A0A194QQ73"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="112" mass="12011" checksum="075E2DE7E051BEB8" modified="2016-10-05" version="1">MSPVPVLYYWKPGSRCEVGFWRGCLPNMNMFHDEYECVATCIFSARAADEDYHNLNAIVESEESTEESTISNDDNSTASDTNNTTTDVTGDGNSGTVTVTGGTGNPTPAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ86</accession>
    <name>A0A194QQ86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein phosphatase non-receptor type 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QQ86">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQ86"/>
    <dbReference type="InParanoid" id="A0A194QQ86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1606"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1998"/>
            <end position="2018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2028" mass="225906" checksum="C850309372514439" modified="2016-10-05" version="1">MEAVPKLPLISFELKVSPENTHFGPKLKQYIAEAYREDPDSYANEIHQLEGLRSAAVRATIDAAGLSSLNRYFCQLRAMQSRFPMAKGQPVACTFAWKDLYANMSCSLADIRFEMASILYNIGALHTQLGAAEARTTPDSLKAACTHYQQAAWAFSHLKEQFPQPPGADVSSEILSLLQEICFAQAQECILNKSIQDTRKPSVIGAVATQVLLFYKNSLAHLGPSTGTDNIHEIIGTKLYNQWHRYLSFKAAYIGCIVCLYQGLNAEEQQKFGERVAFYQQSVDKLAEVRKLAKYIEPVQVTQEALTFTNDVVEGKRKAAKNENEFIYHEEVPEKDLLMDLKPACLVKAVPINFNDPEISGTDIFSRLVPMGAHEAASLYSEEKAKLLRLVVSQVDAKNTELTEFMSSLQIDQLEVLDSDQKIPQEIVDRCAAMNAKTEIIQSLVDSMNNLAEVISDVEHSLSEIKAIIQEETLKEKEYQKVMGPRPPSIVQTEISREFHKYQEAHTRTNESNQVLHKAMTLHIANLKLLSQPLDVLQAKIPSIDNIEGLDRDTMKEMRRVVGKAREMQTQRDALVQQLRAALTADDVTAKLLARTNDSADDIFREEIEKHAPKVKIIEQNLAAQENIINKLTTLYATYAESRRLLADVLRKRDGLINALVTSYDAYEELLGKSQKGLEFYRKMSHNVTQLLARLRSTCQVLQEERQQMLANQNNKAVSGTPASIASAKIPDTIPVPLSTTATPKLKDYLPYMKNRGLARSRTPQEGLDRDTMKEMRRVVGKAREMQTQRDALVQQLRAALTADDVTAKLLARTNDSADDIFREEIEKHAPKVKIIEQNLAAQENIINKLTTLYATYAESRRLLADVLRKRDGLINALVTSYDAYEELLGKSQKGLEFYRKMSHNVTQLLARLRSTCQVLQEERQQMLANQNNKAASGPPASIASAKIPDTIPVPLSTTATPKLKDYLPYMKNRGLARSRTPQATDMTQMSLPDGVVMPPAMHQNPYGRYGTPYAPSEVDPYAVQHTYAYPVASKANIDKPIDDISKYSYTSYTPPQYSSQMADPQTYTNPYYSATHNNATIVTDSQASVNYQNVNQANPNTNANANVQSYNVYDPYSHVSQAGPIPDSMSMYNSANQEQLTANFAQMQVTPPVNQPNKSESSGNLPNEYSQTFYTMQYQHVPSANMATYSHAPQDSQTSSVSSQLPSDYSLNYNYTAEMGNQYPQSVQPNVSSAYGTQYQDTASMPQNYMYTNAESAVTSTTCVVTAPVTVSNPYNVPAEGNPEYNTSLSQLDALDKPIKSHVTGEALSSMDIQSSYQNYTTGLNASNDPNYQTPSTYYQDQNYQNHPGYTYNNSTGNYDYNYGSQNSYSNYAGVCNTVQSPSDNPQIQVSNEQPMNTQIYYNHPYGYQNTQVPNASQLNVAPQQNFPEATNYTSEMNHSTYMQSGVVPGTNVTYIDNQVSPPKEKAPIEQNIETNKQNEIKTVAPEPEVKQTEVKQAEVKPEVKSEPTAFDLLSDIDFNVDYKPLMPEIKVPQVSDKVVIKPTVVPKTEPISKPVPKEETIERPAKQDIFSDPSLLNKFTQEVKQLHNMTDSLTNKTVGGVTILDAKWKMLQDVQMKENMSRTKTVAMQYSEGNIASVVAPFDDSRVLLKSDPDAYINASYYKQLAPWCIPLMISKCPTENDAGTFWKAILEYKIACVVCLLSEIEMQGISYWPTAKGQSLDLAGVRVSLEDVTCTVHWTERKLALSNGKTVLNVTHYQINVFPAKGVRPFYPNVRPNWLMQGTSYWPTAKGQSLDLAGVRVSLEDVICTVHWTERKLALSNGKTVLNVTHYQINVFPAKISCSPLVLLCDRVLASTFSGRLSNQLRGACVQCGAGAGRSALLAILLVAMCQVRAGDVRLCDILESACINLYKHRTNVLEDTKYLADAYKTVLFYAQGVLCSGTTMFNGEAVSMQSGAGVLPRGPTAAISAATANTTPTASDATATRVQKFSRESFEEMRQSPGLKSGDMKDPLNFLDPLWSLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQK8</accession>
    <name>A0A194QQK8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM8</name>
        <name evidence="15" type="ORF">RR48_11190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQK8"/>
    <dbReference type="FunCoup" id="A0A194QQK8">
        <property type="interactions" value="1163"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQK8"/>
    <dbReference type="KEGG" id="pmac:106718753"/>
    <dbReference type="InParanoid" id="A0A194QQK8"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ07634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10249" checksum="766F837E41CAAE7B" modified="2016-10-05" version="1">MASGLESYINQTVSVITSDGRNFIGTLKGFDQTINIILDESHERVFSSSTGVAQVVLGLHIIRGDNVAIVGQIDESIDSRLDLGNIKAEPLGAIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQL0</accession>
    <name>A0A194QQL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element P transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQL0"/>
    <dbReference type="STRING" id="76193.A0A194QQL0"/>
    <dbReference type="InParanoid" id="A0A194QQL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="124"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="290"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="751" mass="86733" checksum="8FF5713E904BB760" modified="2016-10-05" version="1">MLLINLLCFFSGFNKKINLLKQTIIRLRNKCKTQSMKIKMASKVSKSKIFLEMVEQLPEPIKIFTNMQLKYLKKPRGRKYTLKEKILSLTILKQSSKAYNLLKNIFILPSKRTLQKLLSCVVLKPGINPHIMDNLKKAVVKLSTEKRLCSLIFDEVSLAPGLYYNYFHKEIIGFEDYGYKKTNKIADHALVLMIKSLKGRFKQPICFTFCQSATKKEDLKIIIKEVIKAISKTGLKIICTVCDQSAGNMSTIKSLHEDTVQEYVRRDEEFKSNGFEIDGVKIFTFFDPPHLLKGIRNNFLVKNIRFLHNGEVKIAKWEHLIMFMEKDVGDDELRLINKLTESHLIKDKIPRMKVKYAAQVFSQRLSAAIKFCTRNGVLPNECNDTADLLYLIDRLFDSFNGHSYKDEGKKFRTCFKNGSPHLKLWEQVLPSLRSMGFETKKKDGSIKYVKIPSVTNFISNINTFKDMWSFINKHYKITSILTRNLNQDPLENFFCKVRSNGIRNVNPTCDQFINAYKTLLINNFATPHSVNANCEEDNDIILQSMEQFLTGGTACAYDSIENIQINVLMDELETPTEPSQKIIGDLISQETKKYVAGSVLKQARAKVFKNCPVCTDFLIAKQKQETSFIYQRDYTKKSLIYPSTEILEVMKDMFRLISKCIQESPESRLLPDVIKFNIEIGCNFFILNKCKAHATTLKKFIISLTIKIVLYSWCMGVNKILKGKITKFNENDKIKTQACKYYKTHAKYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQN0</accession>
    <name>A0A194QQN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQN0"/>
    <dbReference type="KEGG" id="pmac:106719222"/>
    <dbReference type="InParanoid" id="A0A194QQN0"/>
    <dbReference type="OrthoDB" id="7167329at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="18728" checksum="DF38A3B6AE33D2AE" modified="2016-10-05" version="1">MTEVTFSKFMWEREKEGRAMESCYKLYTWINHTILMLLLQIFWKMSQISDYFKEKSIEDKKTDSFIFSPLSKESKLRRHIRSMSDVQSSTPYRSPFRSRKGTNKILTYDSDTRSKRITYNRHKLLDSSDSSDFDVTKNNLCIEHNIKKHMDSMRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR51</accession>
    <name>A0A194QR51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR51"/>
    <dbReference type="FunCoup" id="A0A194QR51">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR51"/>
    <dbReference type="KEGG" id="pmac:106718463"/>
    <dbReference type="InParanoid" id="A0A194QR51"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18106">
        <property type="entry name" value="SpoU-like_RNMTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053888">
        <property type="entry name" value="MRM3-like_sub_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22435">
        <property type="entry name" value="MRM3-like_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRM3-like substrate binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="47695" checksum="DDDBE05F16000835" modified="2016-10-05" version="1">MANTLCRPLLQTVTIHSATFRFARHYGRWMHRNPAKVILPFEPKDNIQLRKEKVIELDLNDFKKTTKKETSQKNNETLEEPLHTKINFKEVKDKKETAFKKRLFYLSQKKVFDDNNEIIYEKLKDNDSKISSLFVKLKSKKERLRSNQIMVEGWRMIVDGLEAKCNLQYILFSRKEDLNNIRPFMPKTGVQIYKIPYKEMELWSDVETCPGIVGVFEMPSPDKIKRFSKPLPLQFLCDNIRVPGNLGAILRAAVGVGCEKVLVSKGCVDVWDSKVMRSAAGAHFRLPIYPSIEWEEMPQHLPSDTSLFIADSNTDFAENKTEQVSKVGSEIPVLPYYGIDFSALNHITLIIGGETESISEMSYRLGVSNNGSRLHIPLHKGVDSLNTGMAAAVIAFEIRKQLTQAAAKAKLERQAMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRT7</accession>
    <name>A0A194QRT7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRT7"/>
    <dbReference type="FunCoup" id="A0A194QRT7">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRT7"/>
    <dbReference type="KEGG" id="pmac:106718230"/>
    <dbReference type="InParanoid" id="A0A194QRT7"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="309" mass="33654" checksum="CF1012E70FEEB6BC" modified="2016-10-05" version="1">MSGGLDVLALNEEDVTKMLAATTHLGSENVNFQMEAYVYKRRADGTHVINLRRTWEKLVLAARAVVAIENPADVFVISSRPFGQRAVLKFAAHTGATPIAGRFTPGAFTNQIQAAFREPRLLIVLDPAQDHQPITEASYVNIPVIAFCNTDSPLRFVDIAIPCNTKSSHSIGLMWWLLAREVLRLRGVLPRDQRWDVVVDLFFYRDPEESEKEEQQAKEQAVVAAKPEVPPPVHEDWNETVEPVVSWAEESAPAAAPAFGVAAVQEDWVAQVQDEWGASGAPPAATPAAAPAAAATPSWGGSAQDWTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSK7</accession>
    <name>A0A194QSK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSK7"/>
    <dbReference type="FunCoup" id="A0A194QSK7">
        <property type="interactions" value="1206"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSK7"/>
    <dbReference type="InParanoid" id="A0A194QSK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="30916" checksum="DD6B9546B8746A00" modified="2016-10-05" version="1">MILQHVKARCGIYPRSTIQKFAVPDDKVPWTVEYKEYNPPNYTSPSIHGKPWADPDIDEPNFKPTWNSIDGNVNRKSHMSNYTIANGYPMNPVGRTGICGRGVLGRWGPNHAADPVVTRWKKQAESDMKITETPILQFIAIKRGDTGEWALPGGMVDPGEKVAVTAVREFQEEAMNSLAATEEEKSEWKQKFKNFFNGGVEVYSGYVDDPRNTDNAWMETVAYNFHDHDGTTVGALKLNAGDDAVGVRWVDITPNIKLYASHKDIVSEVYKRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSP4</accession>
    <name>A0A194QSP4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA-binding protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSP4"/>
    <dbReference type="FunCoup" id="A0A194QSP4">
        <property type="interactions" value="1742"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSP4"/>
    <dbReference type="InParanoid" id="A0A194QSP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="510"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="833"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="779"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121146" checksum="66413544EEDC735C" modified="2016-10-05" version="1">MSRLIVKNLPNKVTVDKLKDLFCQKGEVTDVQLKYTKDGKFRNFGFIGYRTEEQAAAAKEYFDGTCVNSMKINVEFCANLGDEKKPRAWSKYATDSSAYKKLNKNDQETPKQKKQKLSSAERNKNKIRELLKKHKGDPLFDQFIEAHVNEKTSWIKEVLEEVKISDNEDSGNEAGQNGEENVNSKEESTTVPEVAKSEDKVANKQISDLEYMKLLMKKVDGATNEKVDEKEEQDKPKKVRNRPLFYCKINGLPFKCKKKDIKEFFRPLVPFSLRLPLGKGKKLAGFCYVGFRTEQELKKALAKDKLFIGNHRVHVHKYESQSKREEEEEQINTKKRQEQSNNVESIGESGSIFVRNLPYVVSEEEVTKTFEKYGPLAEVNMPIDPILRQPKGFATVTFVMPEHAVKAYTELDGTSFCGRMLHLLPARTEKLEMEEDDSKGQKLAGFCYVGFRTEQELKKALAKDKLFIGNHRVHVHKYESQSKREEEEEQINTKKRQEQTNNEESIGESGSIFVRNLPYVVSEEEVTKTFEKYGPLAEVNMPIDPILRQPKGFATVTFVMPEHAVKAYTELDGTSFCGRMLHLLPARTEKLEMEEDDSDLSFKEKKAKKLKAQAKSSHNWNTLFLGANAVADVIATNYGTTKEQLLNDNNKNTSAAVRLALGETQLVAETKNFLESNGVYLDAFNKPAQKRSKTCILVKNLPSDTNKDEVKELFEKHGQIARFLMPNHGITALVDFIEPFEAKKAFNKLAYSQFKAAPLYLEWAPENVFVKTIDTKEIEGKQERDSSKEKESNIEKVSKAEKLEEVSKPEKVEEEKLSEEKMEEETETPENDSTIFVKNLNFKTTENNLREHFKNCGKIHSVVVAKKKDPKNPGEFLSMGYGFVQFYRKTQANEALKTLQSSTLDGKTLELKRSERGNVTEVKTSKKSSKATVQNGTKILVRNVPFQANRNELHEIFRAFGEIKTLRLPKKLTTGSEQHRGFAFVDFHSKADAKCAFEALCQSTHLYGRRLVLEWADQTDENEDVEMLRKRTAQAFNAKVPGGKKSRKAAVDVDDFVEGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QST3</accession>
    <name>A0A194QST3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QST3"/>
    <dbReference type="InParanoid" id="A0A194QST3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="572" mass="65260" checksum="9A74E1707C24DC7C" modified="2016-10-05" version="1">MTNMETHARILRRKLNSRKRFGPITLTNSTTDDIVHQENTSEVPLIYDAEKRKKEGLPPVISQSVLLQDYPKNQCWMNVNAQDHFETMDGLDGRYESVRKKYEEAIKSDDFDKQKLDMMLKTKGAAERVSQKSGNDPGIIPAGINLGGYSMMRLRNSILFFHRMKLRNNTHFRVDVLHNNLSNMVLTAKLSLNDLHILGAYERLITESDPSELFYKPTFGEVEEYEKEKSLALNDYTDQVLEKMKKRLRELDFEAVQIPKFAVTAVTGMQIKLTNGVLRGLDTIHRRGVATCKKEDKFRKIDMMIGFSSLQATYQYEAVFNTGVPPINGILFVTAHELTAHMGLVLTKNPQTLNIVIDSVEQAKPESITVEGPANRIIGNFKNLLERHVFTFISNAIIHNVKMISTITHCEPRLNPFHIEEQTFSQENEPNTDGSNKNELSYKNEEQISEITKETNDSESNEILNGDRNDTTNIEISIDKYEGDATSGSSEEEIEGENRSNVKTEEVERIKSHIVFSYSDEHQLKSDNSASAETSETKENKKKNPVLPKHKQKRNEKSSIFINRIPGNKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSX1</accession>
    <name>A0A194QSX1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allatostatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSX1"/>
    <dbReference type="KEGG" id="pmac:106717876"/>
    <dbReference type="InParanoid" id="A0A194QSX1"/>
    <dbReference type="OrthoDB" id="7340102at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264602" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="14512" checksum="464007D978265879" modified="2016-10-05" version="1">MNSGAIYNTLFILLVSYAFFLATASAVPLESEDEQSENALVSRPEAVDVADMSTPWDPITAAALRKLLMQLDAEERLTRVGRSWPQNESRGWGLRAVDGRLARQWRADKRQVRFRQCYFNPISCFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT14</accession>
    <name>A0A194QT14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor Mth2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_12365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT14"/>
    <dbReference type="FunCoup" id="A0A194QT14">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QT14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264612" evidence="11">
        <location>
            <begin position="18"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="198"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="505" mass="57815" checksum="8D6E8AEFC875B6F5" modified="2016-10-05" version="1">MSKILVIILCSFAVTSAVKECADKIDISKGEYLPNGDIDFEGVIYENGDYFYNKSAKTAIACPKLVIRKCCPFGYGRDGSDCVNVTDNFDIAVWDDYRIIEGAKGREMFRFRPGKMNFTRPFVTVLVSAIGPTEWSDNWHLKSDGKLFVELTTSIPPWTVLSPDKYCIDTFLYEDKNGNTKSRLDALACFADETPENHFEVRSTCMLISCVFIIATVGVYAWLPELRNMHGRVLMAYLLCLFCGFLCMSSLQIMLTVDNISSDTCLILTIIIYYFLESAFFWLHVMSFDIWWTFSGKGGMGMSKVSKRFCIYSLYAFGVPTILTIILASLEFSGLPPHPLLPILRYQGCFIFGRSKLLYLYGPMFILFVANIIFFVMTALKIAHIKQQTAVLNSKESAMHDHHRKDKQRLLLYLKLFTVMGINWILEVISALYPDADYIWMFTDAYNLLIGVTIFIIFVCKRKIFHLIKKRYKQLRGDPMSRTQTTSTRTTYSRDDFRLSSVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT48</accession>
    <name>A0A194QT48_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT48"/>
    <dbReference type="FunCoup" id="A0A194QT48">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT48"/>
    <dbReference type="InParanoid" id="A0A194QT48"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="67"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="9">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="160"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="359" mass="40401" checksum="CBAC41A38B808C91" modified="2016-10-05" version="1">MRLPKLLNPRVQKRILMRFGVYDKVMPVETTPSRIVSENITRPDYILENTEYVPKVAEIKNYNQINDMRESCKLAASILNQLHTFIKPGITTDDIDELVHTLTIKAGAYPSPLHYKGFPKSVCTSVNNVAVHGIPDLRPLQDGDIINVDITVFFKQYHGDCSKTFLVGNVDDKGQELVHITEECLDIGIKCCGPDVPFCHIGSAIHRHAKRNSLTVLPAFLGHGIGQYFHGPPEIYHSLNRYPGLMKPGMTFTIEPVLSHGSEHTVILEDGWTVVTEDGARTAQVEHTVLITDDGGNQRDLARAKNQKKQQEIQKKKTASEKTGMSLSERKHRDAELMREKQRKKEEQEGQGARKQAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTV8</accession>
    <name>A0A194QTV8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTV8"/>
    <dbReference type="InParanoid" id="A0A194QTV8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
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        </location>
    </feature>
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            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="914" mass="101016" checksum="27E286EC1AD86079" modified="2016-10-05" version="1">MSSGCEASGVREEIARDYAALQSRLRREFSDRQGKLNATSRPVTTRPVATEEQLSADFRKKLAEWQRLRGGRQPPPVPARQDLSEDFLKKWDEWKHMKETNSVPAWEEEAKPDEVLVQTSTGLFKFQGISRSFTRKLHEWEKSRGIAPEASTSALLRAARQRSKAPAAPLTRTQSDGSVAPPPGARCHGSSLSVNDVDDFDSEYDREHSPEGPEGVECGARGAVLVEVEAEEVCTAAPLVAVSPRHTPQTPIYTYGRPEARLLCETNAALTGTALLQPNGSVVILSDSRTVKSKEHPAKSKSARDQLKIPEKIGRRKVSQQPSIEEDAMFIRKTIEEIERGSSARFKDDITASETEIKDLPSTSKGFTLRTKQDDNPKDIKTKESNEEQRDECKRRDGDKSNGKKKTKSRARLEREQSKPSESDSEPDVDTVTVEIPRRRKRPRRPSERPRSPPTSLHSDSEGEVFVLKLKAPERREKSPEVIVKTTRKIFSPVVRSGESVPRAVIPVDVEDLTGVRPTMDRTNRRTHDNKKKQETEKRKKPELNVRSKSSGDLQEGEDHRPRTRPPLPSSPSSQKKQLPKETAPSIRIMIQRYNKKINEEGNVSGGSSGASSPPWRSPSAERRRPPDMPVGINIRNNPFLEREVKKSASACQLSRHENTSAEKRLTPASCSLEGVLKSQSANALLPEQEHEFPTEDKKNCSQDTIRCAATSTDTVVPITTKPPETPPTPDTHPVLRQLSDTLVPSLSRFVDKTGFFERSLSTMEPPCYGDSGAAAAGLSERAARIRAARERFLASPPPMRKEGTSSANDLRPGDRTSRISCESESAETQGSGTQEQALGRSASTGMVNVERVAWQRVAEGPGRERGGSRFSLARLAARLRRGEQGGGGGAPSGAGAVARLCRQSLLVQLRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUJ2</accession>
    <name>A0A194QUJ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Nucleobindin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_15278</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUJ2"/>
    <dbReference type="FunCoup" id="A0A194QUJ2">
        <property type="interactions" value="1389"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUJ2"/>
    <dbReference type="InParanoid" id="A0A194QUJ2"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264640" evidence="17">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="378"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="378"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="576" mass="66617" checksum="DCDD25EF1B6D7337" modified="2016-10-05" version="1">MKIKESIICLLVIFHCSYAPPVSQDKSKEQDSEIKDDLEEYMEYHRYLKEVVQALESDPDFRERLEKADEEDVRSGRIAEQLDFVNHNVRTKLDEIKRRELDRLRHLATKQFELTNDLEINTGKIPSNEHLDHANPHTFEIEDLKKLIKKTTSDLEEADKQRKQQFKKYEMEKEFEKHQKLEAMDEAHKKEYMEKVKQEEDARKHHQPLHHPGSKQQLEEVWEKQDHMDQAFDPKAFFMMHDVDGNGVWDADEVKALFIKELDKVYGPGGPNKDLHERAEEMERMREHVFKENDRNRDGLIDFHEFMTETQKADFNQDEGWKTIDENQIYTQSEYEEFERRRLEELRYLQQRGLVDAHGRPVPGAEHQIHQAYQQQQAFHQQQQFQQAQQQGYQGQQHYQGHPQGQLPPQYAPGQAPPGYQQGYHPSQIPQGQAQFQGYPQGQFQGPPQGQFQGQPHGQFQAHQSQPQGQQGQAQGQQQHPAQNQQPGNLNQQPPSQTVNQASQQQGLRSDSPVQGQSPPAQGQGGQTQSSQVQGHDQTSQGQNQGQASQVQNQGHPSQGQAPTIQAQPPNVVANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUZ6</accession>
    <name>A0A194QUZ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUZ6"/>
    <dbReference type="InParanoid" id="A0A194QUZ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="7202" checksum="EFCA5FECB5CD6D74" modified="2016-10-05" version="1">MRRKRCGDAAAPQLSRGGDAAEAQSTGDTRRGAVRDEVSPPGSRAAPLGAGDTRGEPARPLARTLDDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV84</accession>
    <name>A0A194QV84_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Mucolipin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08479</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV84"/>
    <dbReference type="FunCoup" id="A0A194QV84">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV84"/>
    <dbReference type="KEGG" id="pmac:106718921"/>
    <dbReference type="InParanoid" id="A0A194QV84"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000033">
        <property type="entry name" value="Mucolipin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="101"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="405"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ07466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="600" mass="69489" checksum="8101C1D3F0E86EC2" modified="2016-10-05" version="1">MERMQSSPDENTGTEEENETPERNLDNRRNVQGYSSCPTTSSNLNQMEEKMRRKLQFFFMNPIEKWQAKRKFPYKFVVQVIKIILVTFQLCLFAHNRYNHVNYTWDNRITFSHLFLLGWDSTREINAYPPGAGPLAVYKIDEFYNTLDYAYAGYANLSNAIGPYSYNDDNNNMPDPVFCLYNYKQGIIHGFNESYEFNSEINETCINFTIPDGQLLKSKHYIKDAGMEINFAALVRAKLMFSLKTINFRAAGPITPPECVRFDVEIIFDNEDHDGQMSLVLEAEPYKLVCNGDKNYITDNKIDQILRSILNILVILICSASLMLCSRAIYRAQLLKELTVQFFRRAYNKELSWDGRLEFLNIWYIMIIVNDLLIIMGSAIKEQIERNQFTNDQWNVCSLFLGLGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKIFRFSFCALLLYAGFMFCGWLILGPYHMKFRSLATTSECLFSLINGDDMFATFSIMSKKSPMLWWFSRVYLYSFISLYIYVVLSLFISVIMDAYDTIKQYYSEGFPKSDLQTFIGEPCIEEVSSGLYRTQSSSSLNAMMNSLFCCNFYRSAYSKIGGGGSNLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVZ5</accession>
    <name>A0A194QVZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVZ5"/>
    <dbReference type="InParanoid" id="A0A194QVZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="39166" checksum="4EE81B7BA094081B" modified="2016-10-05" version="1">MEAIIAWSSHTEPANLSVSVSSESARSIISVVPGNRLPAIAAMGSGHQLTISVEELSNSGGKATLYLGARDGGGTLPQDHHHCFTVHAVGPRAHTRPAHVKLTDYYQPTLNDIQMYTIPEDCPSHVSHDTDTYQQTDNLFDKARSLDTGEILINNDFTFEDIPEGTPLEDPLFENLKEKKDNRNKQENYPANIVKDIIPDKNITKAKLNVKDNSIDYSAILNIFQSQINYINGEIKEINEIIKHKYKINNETSNEKLNAIARIKEDKREINTDRPKIDNPKLSSFHVIESEKDLEVPTGVEGPVPSVVLPPKDFVFNSTGPGTSETFWRSQLPTSDIDKNMRHERKINYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW29</accession>
    <name>A0A194QW29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW29"/>
    <dbReference type="InParanoid" id="A0A194QW29"/>
    <dbReference type="OrthoDB" id="7426298at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264670" evidence="1">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="501" mass="55326" checksum="5CBC6271D3E1099D" modified="2016-10-05" version="1">MLRVCIVALVIFFQIYKVAAGISPIHDFKNKLNSRIVSERYLLKTPQTGIKHFDNSILKATKNVTQNPQMEENLYQISKNLVSAILTKLEIQDKITRITREALDAPGKNKGITAIETRRILDYISRTISSHILSITRASTEPELHRLVYGLAQIAAEVSIVSALKDITYAKALSKKQSVDLSLRKKRAIPLEDKTTPIPQSSSTLFSILLNKPLPSPEIVNSTSPVKENKLYMSNAPYSVISSHDKLPFRVLSLTDGDPLPVKGFLNKTVLDSENSERINNESEAIVIEKAINGTHYVSADSQIISKQEPTAGELIDDWVDPKDHIYALNSDIVAEMELDQPEIDDESVNEKREKQKLERLELKAKKAILYAGDVAYLTAASVVAMRRALTASIEVNMSVKFAKNGMSNHQDLMMNLAKTAAQQAGKEAKSATSKSLACERVIKLAVKFTAQSQGAKLNHVANRIIMDTLSLATLAKSMAFVSSDIAINSLYQATDIKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW63</accession>
    <name>A0A194QW63_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_15346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW63"/>
    <dbReference type="FunCoup" id="A0A194QW63">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW63"/>
    <dbReference type="InParanoid" id="A0A194QW63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="13">
        <location>
            <begin position="35"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ09205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="60266" checksum="330BF53182F17B33" modified="2016-10-05" version="1">MSAVAKTSKYTYRSSGGGTTDVNIEYSTDLSALSRLEDKIRLLHDDLESERELRQRIEREKADLSVQVIQLSERLEEAEGGAESQFEINRKRDTELTKLRKLLEDVHLESEETAHLLKKKHQEIVVDFQDQIDQLTKSKARAEKEKSKFQAEVYELLAQVKNITKEKFTYSKTVEKLEITISELHIKIEELNRTIVDITSHKQRLSQENVELIKEVQDLKVNIENVVYLKSQVVSQLEDSRRRLEDEERRRSLLEANLHQVEIDLESVRVQLEEESEARLDLERQLVKANGEVQHWRSKFEAEAAARAEEIEEIRRKYSARIQEQEEHIETLIAKISSIEKQKSRLQSEVEVLIIDLEKANGTARELQKRTEQLERVNIEIKSRLEETVQLYEQTQRDLRIKQTEIQRITHELDKTREQKDALGRENKKLGDDLHDARANITELTRRLHELEIELRRLENEREELTAAYKEAEAGRKAEEQRAQRLSAELGQFRHEAERRIHEKEEEIEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXC2</accession>
    <name>A0A194QXC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXC2"/>
    <dbReference type="InParanoid" id="A0A194QXC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="10665" checksum="6B27B76427AF5998" modified="2016-10-05" version="1">MSVNTIVTAKNPLRHSLGIGSYLVERRTMMSEGEKPLVEKSECSSFEDLASAATPQKIAEKSAETQKDEWHDLSGSGALLKKVMIPKVCGHTEATFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXY3</accession>
    <name>A0A194QXY3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXY3"/>
    <dbReference type="InParanoid" id="A0A194QXY3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="377" mass="44696" checksum="9B1922901FFF5368" modified="2016-10-05" version="1">MLGFLSDYWKLKVQLLVKEERKLLSFFIKAISTTNEAKANMVKELKLFDKELFFYNVIKRQLEISGMKPWSASLIRALPEAMVFDDLNAKGYQTKNKFERFDEEHTLQALNTLARFHASSIIYEERKSKSLMRKYRINEEFENYLNRGGYKISDPWYYQCMTGALEAVKKYSKYNKDKELMDKIDKQWREVWQAALKLSDSTNQRCVICHRDLWNNNILFRYKDVPNSEPDDCVLVDFQAVRYQEPAGDVMLLLYCNLDPIYRENKVNFFLNYYYEQLKRILFEKGIQINDVLRKELFLASAEEQRLWGLVVSACLIPQFWLNDSLTTKTFGDTENFNQILSKNKGAFIIKMMATNQDYKGTVMSVFDEIVERYCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY58</accession>
    <name>A0A194QY58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY58"/>
    <dbReference type="STRING" id="76193.A0A194QY58"/>
    <dbReference type="InParanoid" id="A0A194QY58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14577" checksum="FB36211E7B59BE46" modified="2016-10-05" version="1">MVQCKKCKQFVSTSKEDVLKCKGECKGVFHKKCVKNNTQFLQNEMCDLCMADCVSESECDKTSGSSAVKNQEKSLRFLKPSAQTPHGASGATEGNIEEYMDKLHALVTENKNNPIVKQARDILTRVDLPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R047</accession>
    <name>A0A194R047_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">RR48_14812</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Ya'a_city_454_Pm</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="22">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="22">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R047"/>
    <dbReference type="STRING" id="76193.A0A194R047"/>
    <dbReference type="InParanoid" id="A0A194R047"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
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    <sequence length="1000" mass="112238" checksum="491863D3228DE7F2" modified="2016-10-05" version="1">MDKLKDIISKPIQTVLVFFVNGKKVVENSPDPEWTLLWYLRKKLHLTGTKYGCGEGGCGACTVMVSQYLRNEDLIKHYAVNACLTPVCAMHGLAVTTVEGIGSTQDRLHPVQERIAKAHGSQCGFCTPGIVMSMYALLRNKMKIDYNDLETALQGNLCRCTGYRPIIEGFKTFTEKWEQNYAKNTQGSCAMGKDCCKLKAKKKTENRNLFNKSEFQPYSPSQEPIFPPELKIKDDYNQHNLLFMGENVTWIRPKSLKDLLLLKKEYRCGKIIAGNTEVGIEMKFKNKKYPVLISPMLIKEMNVCVTSESGVKIGAAVSLTETNNFLREEISRNKQKIEVLEAIRDMLHWFAGNQIRNVATIVGNVVTASPISDLNPIILASSSKLYVSSYLRGEREIIIDANFFEGYRKVALKEDEVVTSIEIPFTKERQFFKAYKQARRRDDDISIVTAAFNLVLEENNDLIKEVKLCFGGMGPTTICATKSSQKIVGMQWNKHLLKVVFESLSEELELDSSAPGGMAEYRKSLCLSLFFRFYLYVYQKVINGLTTPENEICAVQEIQCEEPKSAQCFEIKNNDRKSYDTVGQPVIHTSALKQATGEAIYCDDLPIIEGELYLSLIFSDKSFAKIKSVDAIKALSEPGVVSFISADDLPDECNKMGSIFKDEEIFSSQIVTSRACVIGAIIAKSESAARKAKKLVTVTYESLEPTIVSIEDAIMLESFFPGYPRTLSKGNIKHAFENAKYVQEGYIRSAAQEHFYLETMSAFAVRKEDELEIIATTQNPAEIAHIVSETLRIPNHKVVAKVKRVGGGFGGKETRAAVLAVPVAIAAYKLKKPIRAVLDRDEDMQVTGYRHPILTKYKVAFNDDGKITGAIFDVYANAGNCMDISCSMIERLLCHLDNCYVIPNIEINAYLCKTNLPSNTAFRGFGAPKAMLAAECMIRDVAAKLQKSYEEIMKLNMYQEGDLTHFNQALNYCTISKCWKECIESSNYWDRKAAVGEFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0I5</accession>
    <name>A0A194R0I5_PAPMA</name>
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        <submittedName>
            <fullName evidence="13">Sodium-coupled monocarboxylate transporter 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="13" type="ORF">RR48_15492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="617" mass="67211" checksum="ACA3395C90CFA266" modified="2016-10-05" version="1">MTVYFGWLDYIVFGAMLLSSALIGVYFAFFAAKKQNTTAEYLMGGKTMGMFPISMSLIASYISGISLLGLPAEMYTYGTQLWAIVLSEWLVSLTVAAVYLPVFYNLHITSAYEYLRLRFNQKVRLLGSIIFIIKMMLYIPIVIYVPALAFSQVTGINMHMITPIVCIVCIFYTTLGGLKAVVWTDTLQTGLMFLGVVFVLAYGTWRLGGVQQVFRINEEGQRLEFFNMDLDPTIRHTFWTTVFGNYFSWLASCSVNQAMVQRCLALSSLRRARITIFIMAAGIFTIVSLCCYTGLVIYATFASCDPLATGAIRKSDQLLPYFVMSMAGPVPALPGLFMSGVFSAALSSMSTGLNSLCGVIFEDLIRPAYKSPISERAASFIMKIIVVLVGGACAALVFLVEHLGALVQAGKSLAGITAGSLLGMFSMGLFLPWVNSAGAMAGGVASTLLVGWMSLGTQAAMARGQLFLAPKPSSVAGCPANASAPLLAAARTDFDRSATFFLYRLSYLYYTLVGTAVCVATGLLVSWCTTPNDPAMVHRDLLTPVVHRWLPAQHAHCSRPRPAQPAHTTDYCASLDRLHIDPSGDVCTKIIALSFHVLTLRNVGVKLQYSFIDKSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0M7</accession>
    <name>A0A194R0M7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium channel protein Nach</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_14987</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0M7"/>
    <dbReference type="FunCoup" id="A0A194R0M7">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0M7"/>
    <dbReference type="InParanoid" id="A0A194R0M7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF247">
        <property type="entry name" value="PICKPOCKET 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="538" mass="61532" checksum="11F7FD4CA0339E58" modified="2016-10-05" version="1">MTKVYPQSVLPPRYQKARKKKKSKNKKDDIGVLSLLAASLRHQTTEFFNNSTLHGVRYIAEKERPFCEKFMWFSFTAIGAVATCIIIVSLDTDFHNWDVPFPAVTICDRNPLDEELLQEYIDKAWPAGAPANATEMLQWLATLSFRSIAESASLFVTQHDLVGHTAGDAPAPALDPKDAVFSIVQRCEAAFYDCEWKGDSEECCDFLVPVFTEMGFCYAYNSRHAEKSWPWQSQAQSELFTEAYIHETDSKWSFMFNSFRNTSVIDIYIHSTEEMAGLEQSAQLSWDHRVEKVSFSVKHTYTTEDARQLSIRQRRCIFADEVKLETSPIYTYSACMRQCRMQRSRSYCKCVPHFYPKTKGYRQCSVRELECIARHAAAITDVSRCACELGCSHTVYEVEKLTEIDSSKGPVASNALETEFVSWPMVRYKREVLFGWVDLLVSFGGIAGLFLGFSLLSGVELVYYFTLRACCAAWRDGDALRRERAERLARPKPPYNLSLVPWWKKPPEPQDASPLQVKAKNLQPPKYSPPPLYTQYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0S3</accession>
    <name>A0A194R0S3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zonadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0S3"/>
    <dbReference type="STRING" id="76193.A0A194R0S3"/>
    <dbReference type="InParanoid" id="A0A194R0S3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="447" mass="50948" checksum="B1680B0A8C2BD810" modified="2016-10-05" version="1">MYNSDTVYSTTVFRPVSLSPSIFPDTETPPPQRTRKLETPLHFDGGLFSDIRSSDGKLLSKVTVDRMHSSTRRDVVDTPHVSETSDALGNKDYVDDIVKTETITNEDVFKVKFTPVSYELDGPQQATKLSLERPRTPVIRPTLIDRPITPLNVPMTLFDRPTTPIDRPITPFNVPMTLFDHPTTPIDHSITPIDRPITPLNVPMTLFDRPTTPIDRPITPLNVPTTLFDRPTTPFDRPETPVNRPITPVKLISNDYEDLQSYKIIKTLLKEHSNTKVDNLNYWDDKVNFINVKSDEPVKRAHSPLANFIVSEQLTKIDSYLQESLNVCSENSTEIISKSPKLDEERETKKDIICSTKIENNITSHNYDGYKEESSKNVKDSTVKYNEVEDIQPTTLKVNSVKAKRPGVVNSICNMPMHYHAAILCFFLIVYNLIYQYIKQNHHGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2D4</accession>
    <name>A0A194R2D4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2D4"/>
    <dbReference type="InParanoid" id="A0A194R2D4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="173" mass="19363" checksum="E995E025AADE2CD4" modified="2016-10-05" version="1">MENKIVLTPDKKYTIKARSYENGFQVKNKAGHVKGKFIKSGIARSLDTPRDKMIKGNATNECYDGVKCKSPVIQPRAPDRFLIGGRHNKFRCSVDNVSHASTDLSKYELLRNLSFSNCNSDEGCSGNTCSKNSSPVEYSVKDEHLERYFRSAELWSNNSTCGDQDSVLPNVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3H2</accession>
    <name>A0A194R3H2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homocysteine S-methyltransferase ybgG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3H2"/>
    <dbReference type="FunCoup" id="A0A194R3H2">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3H2"/>
    <dbReference type="InParanoid" id="A0A194R3H2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="450" mass="50873" checksum="EAB5AC9808E03B59" modified="2016-10-05" version="1">MELNENKVFVLDGGFSSQISCHVGTNADGDPLWSARFLKTNPEDVYRTHLDYLRAGADVISTNTYQASVGGFVEHLGVATEEATELIRLAVELARRACDTYLEQNSQPLLNPTPLVAGSVGPYGAHLNDGSEYRGNYADKVSSETMREWHIPRINTLLEAGVDLLALETIPCLKEAQVLVELLKEYPKAKAWLSFSCKDDKKLAHGEDFQTAAVQCWQANPTQLIAVGVNCCPPNIVSNLVKGINEGRKQPIPFVTYPNSGERYIPDMGWTDKDKSESIDKFVHEWLKLGVRYIGGCCRTYQNDISQIRKLKIFGISLRKKEKADEVKMLTNENAQLKNINLELTSETMRMKKRICELQQEKFSDYLTLMRERDGRYTLYHQKLQLEERVKQLTRNVAGARHEDPLLLRVALDRCRSVARHTRCTTPLHCFAHFEPSASALRLLSGNQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3S9</accession>
    <name>A0A194R3S9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3S9"/>
    <dbReference type="FunCoup" id="A0A194R3S9">
        <property type="interactions" value="1510"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3S9"/>
    <dbReference type="KEGG" id="pmac:106714249"/>
    <dbReference type="InParanoid" id="A0A194R3S9"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="327" mass="37151" checksum="5BC6658C26E88550" modified="2016-10-05" version="1">MPSQEVVTTKVVVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRAKGVLDVSNSFAVPFDEDDKDKSVWFLDHDYLENMYGMFKKVNAREKVVGWYHTGPKLHQNDVAINELIRRYCPNSVLVIIDAKPKDLGLPTEAYQAVEEVHDDGSPTTRTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQRITNQLLGLRGLHSQLSEIRDYLIQVGQGSLPMNHQIIYQLQDIFNLLPDIASDNFIDNLYIKTNDQSLVVYLAALVRSIIALHNLINNKITNRDAEEGKKEDSKDKKEKKDDKDDKKTEEKVKADKKEKEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4Q6</accession>
    <name>A0A194R4Q6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Protein kinase C</fullName>
            <ecNumber evidence="2 11">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_10428</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 11"/>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4Q6"/>
    <dbReference type="FunCoup" id="A0A194R4Q6">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4Q6"/>
    <dbReference type="InParanoid" id="A0A194R4Q6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20794">
        <property type="entry name" value="C1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000012">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="140"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="757" mass="85891" checksum="5B9E928817D877C1" modified="2016-10-05" version="1">MPCAGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAFCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKPCSNEHVDPVEVKEDANGEGTLGRASSVRSRAEPEPLPETPPAPPAPVRAEDLEPGSQRHYSLEDFELIRVIGRGSYAKVLMVELKRTKRVYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALHFLHERGVIYRDLKLDNVLLDHEGHIKLTDYGMCKEGVRPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLTYEMLAGRSPFDIAQAADNPDQNTEDYLFQVILEKTIRIPRSLSVKAASVLKGFLNKNPVERLGCGEGAFLDIVNHPFFKSIEWEMVLGSNPAMCFQCVFRFTYVHLSDILMVMLHISEKSRAEPEPLPETPPAPPAPVRSEDLEPGSQRHYSLEDFELIRVIGRGSYAKVLMVELKRTKRVYAMKVIKKALVTDDEDIDWVQTEKHCLKPPPTIPSSSACTPASRRPADSSSSSSLSAAETSYFDLYICAKFHQDLFSSGDTFNHPSIQTFAFIILVILEKTIRIPRSLSVKAASVLKGFLNKNPVERLGCGEGAFLDIVNHPFFKSIEWEMINIVMLHISEKYFNDMCEVNLHWANLVTSNLGTVIADIDQSEFEGFEYVNPLLMSLEDCAYGYGAESSSSDYDSVCSELPARKPTLLQHMFCLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6T5</accession>
    <name>A0A194R6T5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferin 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6T5"/>
    <dbReference type="STRING" id="76193.A0A194R6T5"/>
    <dbReference type="InParanoid" id="A0A194R6T5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="97"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="270"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="532" mass="59966" checksum="1E5CC6190AFD9035" modified="2016-10-05" version="1">MIEPEFGKKYSRSSEPKNLFSRVSAKSLNFFITTTIVIKMSLPKRMNDSVHWFMNDLTSRIIAQSGIPSDRFHLGKLIFQSLKDDQEFLLQIDGSTGESETNGSVLKRSIQCAIALKNLGLKRDDIIVIMAPNHIHITIPFYASLYIGVGTSALDQTLGPNELKECFKVSRPKVIFCQSEKVTDAQLALNKLDHNAHIITFDKGDYHFNYEEFLRKYGDDSAVDEYKPSTFDPETTIALLVATSGTTGLPKSAAVTHKNLAITNPYTWLPTFTIMSPTLMTTLLKNGIAKNCDMSCFELIYLGGSAVSRELLEDLKQIMPSTEVLNIFGMTELSSIAFMQDNGPIESCGKPIGCFQYRIVNPDTKKDIVEPNVSGELWVKGPGIFKEYYKNPQATRETFAEDRWFKTGDIFYRDEHYNYYYVERIKLLLKYRSHQISPLELESVIRQHPAVQDVAVAGIPDAECGDLPVACVVVRTGHTVTAQEIKDLVKDNLTDTKQLRGGVIFLNEIPMTATTKIHRRKLKELVLTMEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6Y3</accession>
    <name>A0A194R6Y3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein CG16817</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6Y3"/>
    <dbReference type="FunCoup" id="A0A194R6Y3">
        <property type="interactions" value="2203"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6Y3"/>
    <dbReference type="KEGG" id="pmac:106712345"/>
    <dbReference type="InParanoid" id="A0A194R6Y3"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="157" mass="18013" checksum="416A0AC6D7F61CF2" modified="2016-10-05" version="1">MTSEIVTPPSVSWAQSNARVYLTFNVECDKPDIKIEKKAVSFKGICAPEQKLNQVDIPLFAEVDPEKSTQVNKGRLIELVLVKHKTDEPFWPSLTSDKKKHHWLKVDFNRWQDEDESEDDLDPMNDMFSNKIGDFGDEDIEKNDSSSGEEEDLPDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R754</accession>
    <name>A0A194R754_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_10837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R754"/>
    <dbReference type="STRING" id="76193.A0A194R754"/>
    <dbReference type="InParanoid" id="A0A194R754"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF9">
        <property type="entry name" value="GLUCOSE TRANSPORTER 4 ENHANCER FACTOR, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="221" mass="24977" checksum="F16850DCCD13D971" modified="2016-10-05" version="1">MLPPYTRPLAPPRPRPRPPRPDLVTNALDVAAVSKRGTIAFRARNPICVPDTAINSVVFECTWRGCGHTTNSCSSIEAHIRNTHLGPKKEGESDHEEEFYYTEREVLAPPPPPTLSHRDMCRPPHEDPDYQRQLVGSYRQGLLSTMHNGSARLISFPVGHPWSSSHSPKHMRLSGMTGSPGSPGRRPRSDNKKCRKVYGMDQRDLWCTQCKWKKACTRFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R887</accession>
    <name>A0A194R887_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex protein 11-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R887"/>
    <dbReference type="FunCoup" id="A0A194R887">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R887"/>
    <dbReference type="InParanoid" id="A0A194R887"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="488" mass="55353" checksum="26B685841E17E097" modified="2016-10-05" version="1">MSDREGPSGSGQKGDKEEKFSRTPSQPMPTGSRSSYYANEPIQFRVRGSTITGASPPKFVTLEDIMKAAHGMQNMALAHEIAVGQDFKLEPFEPPDNRLYANTKVLFNLIPILDSYFTNILQTHGSAQQLFVTANGRPHDLYEDPNKFDKEQNYDVTKLKPLLLYYGLFSILLPRHKRIREMIEEVLDHDFIKQQAENNSLDFNKYATFVVDLMGKLAAPARDEMIQNITKLTDTVDIFRAILETLEILKLDLANTLIAMIRPHVQQESVQYERTKFDELLKVSEATQKQQLKEKIIIILDNTSNDIELKSILPSVAAEIIVFTENLLEGLNQAALSGDTKELIQSQILSLSDPEHRVRQIVRQRIFEFLKEILVCGGGSRQIPVGLSAFTQELTSVSGTLLRYVMHNKAVFTKYYLDIVAEELKPLADRLLDLSEPLPDPEFFLELALEDALDPDALEDARDDAREDLRLAREVARELALELAFEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R889</accession>
    <name>A0A194R889_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R889"/>
    <dbReference type="InParanoid" id="A0A194R889"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="7711" checksum="8F976B202565C156" modified="2016-10-05" version="1">MHLLRVAPAPNAPTFGENQNIGRVSVRLTRKARGLDVASPTRCRYCIVGLVGAKVRYDRLVKVSSLGSKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8G6</accession>
    <name>A0A194R8G6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VPS33B-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8G6"/>
    <dbReference type="FunCoup" id="A0A194R8G6">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8G6"/>
    <dbReference type="InParanoid" id="A0A194R8G6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040057">
        <property type="entry name" value="Spe-39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364">
        <property type="entry name" value="DEFECTIVE SPERMATOGENESIS PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364:SF6">
        <property type="entry name" value="SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="46838" checksum="06E6C6DDF525C3BC" modified="2016-10-05" version="1">MDDDDYWNTSETKAKAFSFDDDVLSPQEILAIGQKPYSGSGEEGILNSSISNIKPALVPISSLVSSKVLDLLVLAQSGKDLKETKSEPEETVAITLKRLVLGRSCSLHVHRSLKSKTELLDGAVAIGDGNAILTVVLFLIQTLNKKLVYELLSSWPLALSHYIGNLQSEGKISELTDLLTMLGRSPDSAIYQFQHSIKNQGDNVDGLLRKTNNLLANHFNQPGVDAHQAKMIADYVKLLEWQSFAKKNELNNKSALECLAYCCKLHWSEGAGNMMSPLTVCQRQQISPLQYEWVVLNVQANLNKWDIVESLFTKKDWLGRTTLSSHIPVESLLARLSELRAGARLLATAVNTVTNTEERLRLAHKYKIHSVVIETLAKQKDRAALTNYKMTLNPQSEEYIYAENTLREPRTCIASQMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R901</accession>
    <name>A0A194R901_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R901"/>
    <dbReference type="STRING" id="76193.A0A194R901"/>
    <dbReference type="InParanoid" id="A0A194R901"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6990" checksum="3D8F6468524BC3EF" modified="2016-10-05" version="1">MLTTILFCQSSNKELLNWLASEAKNLPARNNGAACHRDIYCVLSLDQEEIFRTSTMERTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R959</accession>
    <name>A0A194R959_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like protein involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R959"/>
    <dbReference type="FunCoup" id="A0A194R959">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R959"/>
    <dbReference type="KEGG" id="pmac:106713781"/>
    <dbReference type="InParanoid" id="A0A194R959"/>
    <dbReference type="OMA" id="YAKTHAW"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000117">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="127" mass="14360" checksum="4C9023B179FCBEF2" modified="2016-10-05" version="1">MADEKPSDDVPQTELSSGVENLKIENGQKENGDTNKTDKVKVDILLKATGDAPIMKKKKWAVDAEKPIGWIIEFVKKYLKLEPDEKLFLYVNQTFAPSPDQIIKNLYECFGTDGKLVLHYCKSQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCR2</accession>
    <name>A0A194RCR2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_10880</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCR2"/>
    <dbReference type="STRING" id="76193.A0A194RCR2"/>
    <dbReference type="InParanoid" id="A0A194RCR2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3752" evidence="21">
        <location>
            <begin position="812"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="398"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="554"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="817"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="903"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KPJ13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="953" mass="110530" checksum="441F2B0EA992F8B3" modified="2016-10-05" version="1">MTSSITKAVGIVKDVSPLYYRILSKFPQNFTFCFAYGSAVKPQIGNQKKHNMIDLIYCVENSYRWHGANIEMNPSHYSALRFLGKGFIARFQENWGAKVYFNTLVEMKEEDVTIKYGVVSQKDLIADLLDWNDLYLAGRLHKPVEIIKQTNSSQLQNALQSNLRSAVHTALLILPETFTEYDFYFAISNLSYAGDFRMTFGENKNKVRNIVQPQLLNFRELYRPILQQFHVYVDFATNDLQCHQDIHPETKLHHLMQLPMVPQQRIVKFWNHGGLQQDMEDVLRAVAYDIDCPVILRQILKDIVWQSSVRQSLKGIPTAGFLKSIRTKMLSDESSSDSETGRFKCKTKTQDEAGQHSKSRDSSFHTRDSRGSGRNRRNEIERYHREFERRRDDRRDVFESRERDRHRYSRHSPVRRRRSVERSRHREDSQERRRYDRDSRERFKHNRSRSRDRMRRSESKTHRSPNHVKSKKEIIDSDIIEKKPDKFETNEFDDISSSSEIKSKRSEVFKPDLQDPAREKIKSPVIVDIHGDSDSSVGEKPASYYNMIPAIVKEKSEESSEIDSSDDEKLRAKLLSLEKQVNKTKKRKHRKKHKKKGSRSDKEKSQESTASVEVSSTTDIQDNTTSNKISSSETAEVTSTQKSGQKESSEEGEILSDDESQSPKIDPTDLRHKLKRSTLQSGVCGPALPPHLEKRCEKSASPGTEGPALPPHLSKKPRHLGPSIPQDMRKVLEEKSQEITHFESSDEDVSIVGPLPVGAEDKWTNAHKSLEERALDMKIKKLDGHTLNKVDVKSREQWMLELPEGKTKYLGLEARSFRAKEGPDMSDRSSWTDTPEDKARKASGRMKEEDAAAVLQQEVRQKQIASRDDEQEKAIKKHKKKHKRDESLLEMHQKKIKKKKKKDDKEDEKPERRPFSRDVDLQVNRFDEAQKRSIIKKAQELDSRFSRGEAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD54</accession>
    <name>A0A194RD54_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD54"/>
    <dbReference type="InParanoid" id="A0A194RD54"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9706" checksum="2602015873D437CD" modified="2016-10-05" version="1">MPLDVLGRTRATLKESACSPWPRGPGNPLKLLRAGDWGLQLSPINEEFLVSASHKLALITSLPFVHTARRYYRLNDLVRSSDRHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDN0</accession>
    <name>A0A194RDN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDN0"/>
    <dbReference type="InParanoid" id="A0A194RDN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8940" checksum="3F1510D70FBA7BF7" modified="2016-10-05" version="1">MPIIQWSKQRTRTFTWHGRHTVRTAAWPTPDPENRKAPDHLPSVLQTLKNDSVRLLQYDFWSPGTRHQLISHAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF51</accession>
    <name>A0A194RF51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-xylose and UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF51"/>
    <dbReference type="STRING" id="76193.A0A194RF51"/>
    <dbReference type="KEGG" id="pmac:106711487"/>
    <dbReference type="InParanoid" id="A0A194RF51"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="304" mass="34158" checksum="25C4E7D735CBC467" modified="2016-10-05" version="1">MSLKNTTLNVFISCCVNSYLMEILMAKAPESANFVTFLQFVFISIQGFLFRTFNVFNPNIPFKRYFILIALFFVTSVANNYVYALHVPSTLHMIIRSATSPASTLVSWYAKSRVPKVTSIIGSLLISMGVALAMYGGATVVEEDKGSFIYWCFGVVILLSTLILGAFTGLQQEILYSNYGKHPDEMLFFTHCIPLPLFLTIYPQLKNIALSMSSDLWLILALNVVSQFFCAHSVHALATKEDSVTVTFILTLRKFMSLLISSIVFKNNLTILHVLGTVLVVFGTYIYFDCFESKKQRPVSLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF80</accession>
    <name>A0A194RF80_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF80"/>
    <dbReference type="FunCoup" id="A0A194RF80">
        <property type="interactions" value="1036"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF80"/>
    <dbReference type="KEGG" id="pmac:106709703"/>
    <dbReference type="InParanoid" id="A0A194RF80"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="322" mass="36113" checksum="D70A836382483CE2" modified="2016-10-05" version="1">MALLPPDPVYTIRNVDNSPVYSLAFSFLPGGLERLLAGSKNGYVYAYNLQTNRVQQKIKVGQAPILHLIHTNNQLITQEKGGKFKIFNLTNSGYKEETLIDLDYPGFCRFEANTKLETLYVPDRESSITIYNFSGEKMGSLVPVNTSPKLGDPMCMKYVELASEKPCLIVGYEAGWLLLWDLNTSQCISKLQTKECPMSVDFHVEQQRGIIGNASNMVQIFSIGRKDLSLAHKMDVAIKNPGINKVQSRMDGKVFVSGGWDGHIRIFSWFSLRPLVVLTEHRQAIQDVVYSTEKVSLWNAHIMAAGGLDGAITLWDLYNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG32</accession>
    <name>A0A194RG32_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG32"/>
    <dbReference type="InParanoid" id="A0A194RG32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="26191" checksum="F4941BF982D57486" modified="2016-10-05" version="1">MGYSQLCDNKTRSCTTQILGHDYTEDSCQLEYFKPDSPACRAMDFAPISPNDHIGGVSLKPYSLQYDHVTPLGTVYTVNHTVLNITFSNIKWKTMKFRFQFSKQKNSDNHCRNIVISNNVTINDQSMFYYDCYWPISDGNPNGQSHILDFEATDDVVVNRGQYYFNIPTPQMLICASWLITLRPESVHNLHDLEATITVLGGVLSLTGVGAAALGALTAAAVRLLLLLRSYFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGD9</accession>
    <name>A0A194RGD9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="2">3.5.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGD9"/>
    <dbReference type="FunCoup" id="A0A194RGD9">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGD9"/>
    <dbReference type="InParanoid" id="A0A194RGD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000070">
        <property type="entry name" value="probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF11">
        <property type="entry name" value="BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="8">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="9">
        <location>
            <begin position="154"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="34160" checksum="D04FA89C5FC472C8" modified="2016-10-05" version="1">MRSHTYYESMGAARIMAQIIDGKALAKEIKDELKTKIQSYINLGNRAPSLRCIIVGEDPASHTYVRNKIQAAIDVGIDATTLKYDATLSEDELIAAINSLNTDNNVDGILVQLPLPGKMDERKVCNTVAPEKDVDGFHITNVGQLCLDMPTFVPATALAVVEILKRYKIDTFGRNAVVVGRSKNVGMPIAMMLHSDGKHDSKLGMDATVTVCHRYTPAEQLEFFCRNADIIITATGVPKLIKATMIKPGATIIDVGITRITDEQGKTKLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTLQAAQRLARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGV2</accession>
    <name>A0A194RGV2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAST kinase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGV2"/>
    <dbReference type="STRING" id="76193.A0A194RGV2"/>
    <dbReference type="KEGG" id="pmac:106708687"/>
    <dbReference type="InParanoid" id="A0A194RGV2"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70906" checksum="A4C96FFD7EE2389D" modified="2016-10-05" version="1">MAQILKNVWRNVLSGSSFTKTPFKVANFTTSLSEVGWVKNTDTIMTSIKSAPTPENILATVQQHLPIMTHKHLLQALRSLFELQKSGKFEQTDELIKDPTFSVLCQNFKKHARALDVNEAIEAVKVLSFLSVPVDSLIVQTMLQLIRTNINLINIRQIMFLDFLLNQFDSKNHLVDVLKLALPLTFQIHLPLELDHDDLPLLRDMLIYSCNHDLPDRCINNVVTGLLLHDQRIDAQTAKSIVWSLCQVNCTEKVFPTRVQLLHICYDILTQQIDQLHYNDVLRTAAKIKGRVLEKHPEYYQEQLLDAIADYVIRNNIEFEPALLIARVLSRVAHTHLGLMEYLCNLALNEENNLSTARTNILFSFINCLSNNNYTPDLEQWDVLRQNISENPILSATNAALPWTKVCLELASLGHYDDKLLEKVFSERFLTEYLAREKNILDLLQLLTLHEAVNAFYSDEYKLPEDVIQKAKDAYPIHAATDNVRNCLARGLGGKEYVGKNVVLPNGFIADLFLALKNGTPIMIPQFTQEKEKIPIENLNLPMEVLPTCLLLFNQGCYSMNSNRLRGTFRLVLDMLEKQGYAAVSINVSEWMKTPSHERIPYLMREIDYKCGEMGMKLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH64</accession>
    <name>A0A194RH64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dual specificity protein phosphatase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_10378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH64"/>
    <dbReference type="FunCoup" id="A0A194RH64">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH64"/>
    <dbReference type="KEGG" id="pmac:106709037"/>
    <dbReference type="InParanoid" id="A0A194RH64"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000056">
        <property type="entry name" value="Dual specificity phosphatase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265197" evidence="12">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ16779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="25594" checksum="CA7420EFECC447E8" modified="2016-10-05" version="1">MLRSAFVAAFLSIPNPVLAFNGLRSWARRVVYEKIDLCTQSCYSQIVPGLYLSNAKAAVDADVIRALNITHVLTIETHRIPKSAFPNPHVATLFIRAYDSPHTNLLPYFPMANAFIDEGIHRGNVLVHCHFGVSRSATIVIAYLMAKYQLTFEEAFSYVRNRRRFINPNPGFISQLKEYERMNYDVSSFLRLEAYLNVKAREHKYKIASVTAIFVGILVPLAVLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHN9</accession>
    <name>A0A194RHN9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein real-time</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHN9"/>
    <dbReference type="FunCoup" id="A0A194RHN9">
        <property type="interactions" value="1129"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHN9"/>
    <dbReference type="InParanoid" id="A0A194RHN9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF66">
        <property type="entry name" value="PROTEIN REAL-TIME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="57"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="46420" checksum="26DA8B9CEDEF3454" modified="2016-10-05" version="1">MYQDFILICDLVPSDTTLLRFLRARDFSVEKAREMLSQSLLWRKKHQVDRLLSEYETPDVVKQYFPGGWHHHDKDGRPLYVLRLGQMDVKGLLKSIGEDGLLKLMDVKGLLKSIGEDGLLKLTLHVCEEGLRQLEEATRKSERAVHAWCLLVDLDGLNMRHLWRPGVRALLRIIQVVEANYPETMGRVLIVRAPRVFPILWTIVSTFIDAQTRFASGWWWRVPQRCYFTSFVHEGGLVPKSLYVSGAFTERDGDPLCEDSIYHSVSLAKGQVHEVVVRNCDPHSVLTWDFDVLRHDIAFTVFRTAHDLPAATPSAEHNATALCAGGGAEPRSLLQQLEARGWREGQHYQRVEPTLVCHDGESIQGSHVMTECGSYLLQWRCELLDSAHRAAQLMYFHETLASHQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHQ8</accession>
    <name>A0A194RHQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">RR48_13830</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Ya'a_city_454_Pm</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RHQ8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHQ8"/>
    <dbReference type="InParanoid" id="A0A194RHQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
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        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
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        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Immunoglobulin_dom"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="RTK"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig_3"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01832">
        <property type="entry name" value="VEGFRECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    </dbReference>
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        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
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        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
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            <begin position="219"/>
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            <begin position="416"/>
            <end position="506"/>
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            <end position="603"/>
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        <location>
            <begin position="609"/>
            <end position="705"/>
        </location>
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        <location>
            <begin position="790"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1229"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="993"/>
        </location>
    </feature>
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        <location>
            <begin position="797"/>
            <end position="804"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="997"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="998"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="1011"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="22">
        <location>
            <position position="1136"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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            <dbReference type="ARBA" id="ARBA00011902"/>
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    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <sequence length="1325" mass="149665" checksum="1B3628E0C4ECE55C" modified="2016-10-05" version="1">MLVRMAIANAYETEGPIIDPSLKEIVLEKGQNFTIKCKGFSELDFKQQDIPEEIVGSLFNKSITTVTNSDDKYKYKIELNLYNVDQFAIGYYACFDSTLKADDLLNNLMEEPKDTEHVTYIYVYVNGTNSVFAPMREVVKTGNGSKVVIECRPTTPDIKIKLTGDFADYEHYDPKIGFTVDSDYILDLPIVLVTCDAKKGDLEDSKDVFVHKLTNIPPPQPRIIGGLQHFLSGETFSLNCTVEYQSNSALALSWRTPNVASKIQHKTNENETTGGILYNNITIFNANVEDAGNYTCISKNSYGQNIATFRKLYLETGFIKFEMGGRKINPTVTNQKSMKFLFFLEDYPVARITCYCNDKEIHPKTVKYDITRPILGQVRLYIRNLTVTDTANYTCVATNEYDSKSITVDLRVKAAPVVDFGTYDDIKSVEGTIANLKCKATGYPTPNIEWIFISESGDQQILSPSDTVSTLISTTSYVQIPVRVSGNITCKAKNAINSAAKSRKFIVQELVGGFGIKDIDRNWFYESQNVVLTCVASIYDFANLTWIGIDDMEILDSVEFSNNSFSYVAKLKLNNIAPQNAGNYTCNAVRNDNTEESQSIYITVAAKQPPIITEPLKEMNEEVYPYQPLQLTCQAEAVPPPRIEWYKDGNPLSNATNTDIITEMLDHSKINSSVVIKQMLEENKGKYECVAINKDETTREYFNIAIKEKSTNKAAYLSVIGGIVFVLLLLIVYLVWKIRKEKQFRKELAAAGLLYFKEGVTKSLNPDIGIDEQAELLPYDDRFEFPAEKLLLGKQLGAGAFGVVYKAEARGIINAEETTEVAVKMVKKTADNMYIKALATELKIMVHLGKHVNIVNLLGACTKNVGKRELIVIVEYCKFGNIHNYLQKHREVFIDQLTDNKDKNLGKVNKDYFSSNHTQETDNTFLNTGNTNRSGRKVSETGYVQPEWRSNYESDYSDGRAPRPLFSRDLLAWAFQIARGMEYLASRKVLHGDLAARNVLLADDNIVKICDFGLARSIYKNDEYQKKENSPLPVKWLAIECMTDRIFSTQSDVWSFGVVLWELFSLAKTPYPNISPPSLLQWLSEGHRLEKPMYADDRLYEVMLRCWAQKPTARPSFTQLQEILGEFLEDNVRNHYVDLNSAYIDMNVKTEGQEDYLAMVCAPDYNNLVTPSPHQYVNDSRSFFPPTPTQLQHDDEGYLQMSPATQQTIFSPRATGTKFDFDARKLNPRTEATTHGSELTPMLTLNNLPARSGSESDHDGNSSPYLNMCPRIEEESDDVFETKQNLKNIQNSAVSNPTYITFDVDLDKKPKNSNNYINVPNGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RII4</accession>
    <name>A0A194RII4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SID1 transmembrane family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="76193.A0A194RII4"/>
    <dbReference type="KEGG" id="pmac:106708264"/>
    <dbReference type="InParanoid" id="A0A194RII4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF14">
        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265233" evidence="9">
        <location>
            <begin position="19"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="783" mass="88738" checksum="DF6305B0C3572B80" modified="2016-10-05" version="1">MFLFILSFLLAFRYNCEAQNNAGLDNVTHRNFIYNTYEYDKIISVTVNETTIQTLDFTEESNKWRGYPSRVHAALNDTLDGEYPVFITATQQKGVSSWELPLVVATSNAVLQFDDMARTLCPHDAGSNITSENRPMIQITTANPHNTSVNIKLRRVTDFYVELDKEVPLNVTPSTPKYYYFSFDKDPLNTSHIDKSILPRFNYTIPKSVMLMIESDDTVCAVVSIQNNSCPVFDNEKDMLYQGYHLTMMTKGGIIITQSMFPVGFYIVFIVKENNAECTGVGTDTVSSFQDWIVDGRVKNFRFRVVPALTYTEYISGVLAAFALVLIVAIFAPLLTLLRCNFTEEITVIEDEPGPSSSVNAASSETQPIAHIDDSDSEVDLEAEKEPMPQEIVLSPPLTLAGLSRAKPGAHSRRSDRYHHYNTQFSSHLLLNRMVFQTGNQDLCYYNFLCAHPLGFLSDFNHVYSNVGYVLLGLVFMAQTWWRQIRAANHPKNLGIPQHHGLFYSMGLALTMEGLLSACYHLCPNKMNFQFDSSFMYVIAVLVMVKLYQNRHPDVNASAHSTFMLIAVAMFIGYFGITYPSVAFWIVFTILHLYVCFVLTMKIYYVGRFRMECLILKRAWVSLRTHGRRTFLPSYTARALLLAVANVANWALAAYGMYSHNKDFARHLLAILMGNAILYMLSYVLMKLVHRELIPAYVWVQLALAHAAWVLALLLFLDSRTKWSETPAQSRQHNAACTALRLLDTHDLWHLASAAAMFLSFNALLAIDDPLVNTTPRHLIPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ29</accession>
    <name>A0A194RJ29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ29"/>
    <dbReference type="InParanoid" id="A0A194RJ29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF88">
        <property type="entry name" value="DEBRIS BUSTER, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="580" mass="66720" checksum="3C100D5E490AD9CE" modified="2016-10-05" version="1">MFSICTVVLGIILSFVPWLDYIIFRELRLWNGSLSYSYWQKPGVVRLTKVYIFNVTNPHAFIENGEKPKLAEVGPFVYREDMEKVNIKFHDNDTVTFQHKKILRFVPELSVDKTQKLLVPNIPLLTVTSFSPNLAGFVFNLLVTGLAITYKDRAKPFVHVTAEELVFGYNDPLVTLAHYFYPKGKRPNSQMGLLLARNGTLDEVSTIYSGERMDRFGYLDKVNGLDHLPHWRDRPCNDIRASEGSFFPPRAVTKSDLVYVYDKDLCRILPLQYRNDVYKDGIKAGLYTPPNSTFECARLNPDNRCYCEGEECPPRGLQNISPCQYNAPVYLSYPHFYDADPTLLEPFEGLKPDKKRHETYFYIQDKIGVPLEGFVRVQMNLKVNRAPNIKVNNIHKFPDMMFPVMWIEEGIHEVTPSIWRWIFLATTVGPIAAPVICYSMIIIGLSILITIFVKAYKNFVIGQNSIEIMELGKETLRRGSTLIINGSHKLIHKDNVYQPLNQSDPSTPNSEEKLHELKFVTRSECFSRSLDEVNGNVRSGFVKSNFCNPERESLINSDNSFILSEHRRCRVFKLPDSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJI0</accession>
    <name>A0A194RJI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJI0"/>
    <dbReference type="InParanoid" id="A0A194RJI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="3"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="553" mass="62649" checksum="40A6A772842C9DAB" modified="2016-10-05" version="1">MVQVRVKEGMLEGELCEDEIGGTFFSFRGIPYAEPPIESNIRFNTFLPPQPKKAWDGVRDAKKFGPICCQCNLNKEDVAPSASEDCLFLNVYTPDIKPKNALPVMFYIHGGGLVSGSGNDDMYGPEFLVRHDVILVTFNYRLEILGFLCLDTEDIPGNAGMKDQVAALRWVNENIASFGGDSKNITIFGHSAGGLSVSYHLISPMSKGLFQRAMVMSGSLTCPWGQMFEPRERGLALARKLGCYSEDDKELYEFFKHQPVEKLIGVQIPITFSEKGKGLYDLMFGVVDEKQFGNTERFIFGDVIEKLRNGIHEGVELVMGYVEDEGLIHLRIGISLEETCNYANEFREFFVPKLIAHNCTLAQQFEIGRKMKHFYFKDEVVTMVNLKELVKFNSLHIFTYPMFQLARSCSLKNKVYFYKFTGKTERNFMVRSLSLEKFVGDKIPVCHADEINYIFPMKKENLKINKNAKSFKIINHTTKLFTNFAKYGNPTQEGMFGLQWTPYKMNEQSYLDINENLTIGFKPDKVAPDGDTTAGLNSSGFGLAENVSRAYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJY6</accession>
    <name>A0A194RJY6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJY6"/>
    <dbReference type="InParanoid" id="A0A194RJY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="282" mass="30782" checksum="883FB0FD3486A9DF" modified="2016-10-05" version="1">MQTSYKRMRAVCRHSRSRCQLRGRRMWRHSDLPHAKGWLLFTAHAIATVSCSLSLLITAVGSIKPLAARRVPSVFHEVFEWLTTTSCHLYTELSRAFFGISTLAQRPPLVLTACTLYISTSAALSAGLCNNCPRFFHCRQLLPAARLQQAAILPASHPRSMAIARGSGPPEASARGSSTAVRYTSRSTSTATARGSTTVSNYCPRLDHRQQLLPAARPPLAETARGSTTVSSYCPRLDHRQQLLPAARPPSAATARGSTTVSTYCSRLVSAGCYCSRPNHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJY7</accession>
    <name>A0A194RJY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein CG7065</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJY7"/>
    <dbReference type="FunCoup" id="A0A194RJY7">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RJY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="835" mass="93849" checksum="01EC41FC90D8784A" modified="2016-10-05" version="1">MTVVNRLAQRIEDKYGRLKPVNIDKDEFDRDKEAIIQWIFKGYHFSEDLGHTFEEVVDEELIKSLTESTKEKRDERNPSPPVVSAPTRPRTSSVNTGHQDVRAGSVESLSDVSEDELQRDGPTFNKEKKQQDSYSNNRGQIRSRYANKNATDNKAKPSNKNYKMVLLQEKKRLAIDAAKETLAYHEKNPEKHPLYPEEWKKFWNKRYKEIQAEGKDPSKHDFKSEWIPFWTSRMKELHDEELRINISELYRKMGVPLPESELSILSRHSPDDRSSGGRRSPSSRGRPRSNSRSPHKNRPLGPRRRSPIPRRRSPDPRRRSPIPRRRTPDFRRRSPDMRRRSPDMKRRSPFPRRHSPDGYDGPPSPKRKSPYTRHRSPTSYRRDRRSPMMRRRTPEHHHSRSRSPYKRRLESPGVYSREGRRRDMSPLSQRVEHRNLSPSAHTAPSLQTVLISDEELRPDDGLSPWNSDNDIDSVDSIIDRRSHTASVASRSSRTAHGPHGSHGGHGPHVGHATRSTPGAKPPAPQDFGPTDNVIATLRLLVALEDYLGSLGPKVVDLLTEALKMEKEKANSSEELLEREGAVALLETAKEKLKGAAQAGLVTGSAAAAVRATVVRLAAALHEADKRNRDRNTNAATGRKKNEGGVVSKEAGGGVVSVAGVGAVDRAEIAAQMAAALVAEGRTDVSPQELEQLIDAVVGMAEAKKRESEAKKRNQLASGTASSSTRTGTTSALQMLQSAYDDPNAPPPRDDASDAMDGLSDSDLETLLKNFNELSAEEQHSLIAYLKKLEMRAPQRVEKLRRFVGAAAAGVHDAPDTPDTPRHYSRPRQRPRHHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK79</accession>
    <name>A0A194RK79_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK79"/>
    <dbReference type="STRING" id="76193.A0A194RK79"/>
    <dbReference type="InParanoid" id="A0A194RK79"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytohesin Ubiquitin Protein Inducing" evidence="6">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="565" mass="64510" checksum="9E46CF5BECBF7235" modified="2016-10-05" version="1">MGSDLHSDKQDKLLKLQARKKELEQMLLSKNEELYKLCVQEVQLTGVMPPEAPLSPEVPQRERLGSVRSTERSTDGTDVQDGSDTSSRRIRTGPADRTLECDPNVRKNMCHRLSTPSISGMSKSSHSRQLRRPETSCSNFFPSPPQERYPETFSIHTSHTYPALTGRHDSAPSENIQNELQQGPVYRHHTMTTEYSNRMYYNNPIEGHNATRLRETHFSSSHPDITTHYTHGTIAPQPVPQQNGVRNTPLLYQYASHLKAQSQHLGALAYQHQMQMQSKRRNDGVRRNTLQRTQTYHLTSHSDYNQHLENMSDAYRPPGPVYQHRSQHDMQEQPAERMHPVERLATVPNSLPLRERNVIRNPIHMQLQVSTDDYGFEDRKNYPDALSPVSQMSGYSQGNFDSVSMNKFSPLSQADGKVKEKQWYETSLDSPTKPEMPLLKKTSSLKRTPSLGNSQTYEVMIASGRHSAMQSPHLIPHSPPVLSPSAVSLESPKNMTVIEQGKCIPYREETKPFEMSDFYKYSTKFRQANVQKAPVTPAPNMNIAYNKVPMDMPQFSQEHWHGQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK94</accession>
    <name>A0A194RK94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor E2F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK94"/>
    <dbReference type="STRING" id="76193.A0A194RK94"/>
    <dbReference type="InParanoid" id="A0A194RK94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="626" mass="67671" checksum="B764DCC6852C4CA2" modified="2016-10-05" version="1">MDVCLLEGISKTAARISLKFGIDVETQFGGIKTFASKTLNVVLWFSIRISFAYTFPMPRGVKRGQAEGEAEVVVRVGASPSHTTLLEDSPSQPISYHLLDHGYGATPQHQIRREAPSAPPKTSEAGVDVLAAGPLAHLLRFTDAGTHGHKDFISSVSHEARVSFADAALLPIANSNPFKLKITSVRNKMLRHATAVKRRLNLSESSSGSQGHVVPMKADFKTPKQKRVKVLTPYSRPSSSMKKYTERSRFDTSLGLLTKKFVALLKSSPNGVLDLNIAAEQLSVQKRRIYDITNVLEGIGILEKRSKNNIQWKCGVGGGAGEEVRARRLRREVRALGLREARAARAVAVAEHALSRLSAEHGALAYITYADLRSIDDFRNQTVIPIKAPPDTRLSVPHPDEKGYMIHLKSMSGEIEVYLCPKDPPASPPSSGLLPSDPLLEDNKALLAPLIAQMQSRPSSSIIADFTTPIKRECEEQGSRSLVVRTPCVTDPTLPLAASLGASLSTTLGTSMASIGSSLGTTLGATLIAGLSTPVRHPPTSPTQSPTLLSTPDMGGARGRLRNALIADSDDFAPIMGGGRFQMQTEDQESEPLEPFLALEPPMSGTDYGFCLDHDEGLSELFDFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPL8</accession>
    <name>A0A194RPL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EF-hand domain-containing family member A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPL8"/>
    <dbReference type="FunCoup" id="A0A194RPL8">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPL8"/>
    <dbReference type="InParanoid" id="A0A194RPL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="412" mass="47760" checksum="2402DAB4B417B6EB" modified="2016-10-05" version="1">MTPQDFLESVVEQEPRPRLKRRVLTTKEIEQLRDHTPPLKKGSPQMFRNMRDKGIISYTEYLFLLSILTKPASGFQIAFNMFDTDGNQRVDKNEFLVIQRLLGGSLKERKDLDPHSQEALLTLVSTSALKNKLEQENVHKPSTMEKIFSFAWKGKRGIGSEQGEESKESKEGKEDKGNVPQDTYVNDDQGLQRRHNVDTFLQLLTLVSTSALKNKLEQKENVHKPSTMEKIFSFAWKGKRGIGSEQGEESKESKEGKDDKGNVPQDTYVNDDQGLQRRHNVDTFLQVHFFGKKGTNDLKFEGFRQFMENLQTEVLELEFHEFAKGHETISEVDFAKILLRYTYLDTDEYDMYLDRLLDRVRDERGVTFDEFKTFCQFLNNLEDFTIAMRMYTLADHPISKGISFVCFFGIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQT1</accession>
    <name>A0A194RQT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQT1"/>
    <dbReference type="STRING" id="76193.A0A194RQT1"/>
    <dbReference type="InParanoid" id="A0A194RQT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="313" mass="34425" checksum="02D61F30FC83FFD9" modified="2016-10-05" version="1">MNTVHVCVGSELRQELAVWRRAAASLASYSRDEDIVRRALEKKVQKLHATLQKRESGSGGSKSDPLFCSTLAQMKQKYRIRDKPLLVKSVVCVAFVVVVFFLHAIPELREYYIVISRPFVKRLSLGWTALLGALLLLLLAEREDLEPVLARVEWSTLLFFAALFVLMEALSKLGLISWIGRMTESLILQVNEESRLTVALLLILWVSGVASAFVDNIPLTTMMVRVTAALSAPGGLALPLAPLAYALSFGACLGGNGTLIGASANVVCAGVAEQHGYRFSFLQYLKVGFPVMIGNLVVASVYLLFCHSIFQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRQ9</accession>
    <name>A0A194RRQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein split ends</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRQ9"/>
    <dbReference type="InParanoid" id="A0A194RRQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1355" mass="151072" checksum="A1F3602416CA0D31" modified="2016-10-05" version="1">MEDIFGPLSDESDKESRSRKSSGNKLEYISQDLDAITAQYAKSNSLIHSEEHKETDKDDNKRRKDKRRKDKKNVTKDDDNSLDVDAVSKAIEARLFADSLCLDDSRAKTVLYENQASPEQSDHKFDEITTKTDYSKSHERHYEKFKKEFKEREKRKKRKKNKEDRQNRREHHHFHHHDKTKAEEIVSVVQPEEMPKTLLKDIPLPSEIQKVETSDNSEDSKLTLESQSMPRLTDTPPMLVLEDRIKHEFDSNKIMIVETENDVQHIKTIEIKEIPMPPPYNNTIENISEVPLPKDPPNIEHKIDSYIPVIEIDDNETAVRSISNLEKETEKPVEKVDPHSCKVDKKLEEKPRAIISQEETEDAVAALLGESFGGKEDSFNICYEKVENSSVREIEIENTAIENDNIPEEDAEEMRQAVQNLNASEMEIKPDTPVSDNDLLLIDTDTEEAEDTSQDAIERLPVNIIATNQSLNNNTKVSTSKSEEVSNSIVSKPKTTVVSCNNNETDDTKNKESIITCALPKRDTTVDQPTSTATPVITSWTLSNKLLEPQLLNISSSPAPCRDTNDKKPANIAANIVQIKTSTTQVNNSSKPVLNATRVSAPYQVINHIRPQIANMQPPTIKIPESHILYQKQQGIVISPKTTCDPRLTSPKASPQGDNVTSPKLSNMAILSTSPQSLNNVGIKSPNALHQRPPSQVTVVRMQQPPLSPIQTMHIPVGARTMVSPSRPNSVLVQTGAPIHLNRLPVAPVLTPISKQVSASNMFHQTKTNNVNSSSVTNQPPILGPECKKNDSRNVPENIAENTKIILSPTRIQPNATVLTQNRIISMQNAMHAGSINPTLQMPNKIMINKSPKTDKQEFQCQKSEHSNITFNNKPIIHVANVSHSGASIIQSGSKPVMCTIQEANSINRGQGSNVIHTLSSQRMLTSLNNVIQLDSNKIPASVLSVSAIRPSTVLTKTDSKNCTATTTSSLTNVVMTPLILTTTTGAKTPIRINLKNDTDHVENTFGITLKNNVPHDKENVVTEQKDFVFSNTSGFGKEPLNKPAIATMEVDSGNKCETDFEELLKDNTNEIKVTNDPEKKLEINVGKTVTLITHCKETKNSENNPEREETTNVPILNECNENSVAVSKNKNDKPISSQNDNTDNLNMAKDSFNKISEDSVCNENVEGSEATSNFTANSIISEPDKVTQTETIKLNKENTFSYSNMLSTENDSESQTKSLDENDYWSAKDINIESVIKKVDSLCNDNIELNEKRNDFKTNTTEVITSVLTYPVISNNCDKESTKSLETENDNILNNQFDDDIVEKQITPTSKRGGRSVRGKRGERKQDRVQTRQIAKPARGTGSGKRGRGRAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRS9</accession>
    <name>A0A194RRS9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_07495</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRS9"/>
    <dbReference type="FunCoup" id="A0A194RRS9">
        <property type="interactions" value="1506"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRS9"/>
    <dbReference type="InParanoid" id="A0A194RRS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="251"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="54264" checksum="FCBFE994AB2262E1" modified="2016-10-05" version="1">MNENEDEVTTFCDSAASLVEGCRLPVRMQGGDDWPLAEIISIKEIRGQRGYYVHYVDFNKRLDEWVGESWLDTRKVQFPRRDGAPSGGTTTPKKTHIGSGGGIMPHFINDNVCPEPQKSLSNHRETAAKQQQQPKLPEKIHNTNVLNGSAQKYTPAVAVTVEPRQLISRPASPTLVSETNTLVNGGAVLAAALQKKINRKRKANSLDTEEPPPQESLEGGKEQAASGTATPTARPRTSGSLVAHGHDDLVTRMKNIEMIELGRHRIRPWYFAPYPQEMVNLPCIYICEFCLKYRKSKKCLERHLIKCKLKHPPGNEIYRKGSISFFEIDGRKNKCYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDARGFHIVGYFSKEKESTEDYNVACILTLPPYQRKGEICEMTSIKKEDVISTLQNLNLINYYKGQYIISVNQETVQQHEKAMEKKWLRIDPDCLYWTPKDWSKRAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB49</accession>
    <name>A0A0N0PB49_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_05117</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10221"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="15"/>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB49"/>
    <dbReference type="FunCoup" id="A0A0N0PB49">
        <property type="interactions" value="1394"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB49"/>
    <dbReference type="KEGG" id="pmac:106716366"/>
    <dbReference type="InParanoid" id="A0A0N0PB49"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF43">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="358"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ09915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="523" mass="58758" checksum="16A2F816BFA85620" modified="2015-12-09" version="1">MSDFEEKKHLITRNLQEVIGEEKLVEILKQRDVKIYWGTATTGRPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWDLLALRTEYYEAAIKAMLTSLEVPLEKLRFVRGTDYQLSKEFTLDVYRLSSVITEHDAKKAGAEVVKQVEYPVLSSLLYPGLQALDEEYLKVDAQFGGVDQRKIFTLAEKYLPRLGYAKRIHLMNPMVPGLTGGKMSASEEDSKIDLLDSPAVVKKKLKKAFCEPGNITENGILSFTKHVIFPLMKQDEVFKICRAEEHGGNVVYCKFEDLEQAYAKQEIHPGDLKASVEQVINKLLAPIHEIFKDSKLQELTKKAYPPAKKVTANAAAIDEVTPSKLDIRVGRIVEVSRHPDADSLYVEKIDLGEEEPRVVVSGLVNYVPIEEMQNRDVVVLCNLKPAKMRGIESKGMVLCASIDDPKQVEPLLPPKDSQPGERIVVEDYVVGEPDDVLNPKKKIWEKLQVDLKTNVDLFAVWQGNKLISKVSGNPVTTKCLVNAPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBA2</accession>
    <name>A0A0N0PBA2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PBA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1509" mass="173272" checksum="41850DFEEC4B2F01" modified="2015-12-09" version="1">MIYVAISVGDEETECVPFLSEYTDCSEANVCTGCTKCSCSAEGQWQCQLVQECPGSGDEDVVNADTISNAYDVLFNELSKMETKVEPIDPEIQPEESRLLGNYEDLDEGQHMAPIVKRSVSQNTSTNNANGTVKFYNIVDEINEDTLKNTNESGTIEAKQFNGVKVPKISRRTSVMNTKNITGISDLHIDFHQPKEFDHHIVDNKLDSLVRNEEKLKILNPSKIGEVIGNHSQQSKDKDLSQIVVNELKKGSEIIGNKEMTPVSNITFTPENDTLTAMAFIAGDLLSKLWKIEKESSVESMETEVLKHEKLADLLELFKEPLTMRQELFIKNALQRLSKALDKDRKLKNVSLCETLASSESILGNSSNGNHEDVIEMHTNCKNSNDSKHQHDNNPSVNGTIEAISKIQSVLNLVRKFENVEFKLNMLRNGIYNENNTQDIDLMLSKDESKSFNVFGNILEKITKLLLPKKSKKAKKFVTKVRHMNLFGNSDDIKKELKQIMGINSDHLNLTSKDKLVIDYLNIFKMNPNCAFKGISQKDASVLPSIKGDTYDNISKLLNVKSMDDIVELISPSSNSNTRKKEKEIKNITTEAYFQTNNDKNEDEKFNSTKNKLKAHISAIFNDLKELQNQSGNFLKENKDIVNILPCLYNLFDAAKSEAKEITGVPKGSNLSNISLIFESLRNNLIGGSVSRRKEYTILPGSTKVWERVIKNLNKRSKDSRRNFNSGHKSFHEIKKIIDNVDMSSNSYKEYANLANVAVSSHLILLKVVQASVLQIVNALENIKSFIKGYIELPADEEFVIKKFIDSAVRSIYLNKRISDKLKSYKKKLQREDLSNFRVEAVYKQAMRNPDYNVLETPTHGRYDEQKVEYNQGKVFTNNRFIDKPKFLSYTVDTRDVSRQSLNDKTMKFQEVDINNSNVFKLTRDQIISQLIKNRIELYIRIKEAKGIKSHPDINYNLAKRIRNQLETGNYGLAKELFSVFITNTVTDTNEFSSKNFSKGSSSQHVNIDKDTIFPLPQVNVKNSRNDVKFVASEDFQTDATYSVNITEKCPDDRYYYEEDLSSNEVDSGVCRLCFCKNNTAVCWLRPKYQCHTKIYMRMNKSKKTSHSCKPLGTTLSDDCPPDDWCLGCTVCDCERSGLWNCHILSVCSDRKLKKHYQNNNKTIKRTPVEIHSNLDNQNKINTTKMHRLARKMDVNHNNVKSWRQEFSTTYQYPFSPKHDDNVVIFQKDLVERKSKDIQGVRIKKIINENNINARYSHKVVQRAMAAVHKIINKTERNFTNSTKHKVIHKRSMPQHDIKNNYQHQTTYVSPHMYKKSSPKRFRKKLSLNKITKEELRKKRIRRNITNQGNFTSTTVKTDYNNTLKSPQDKVPNEKPITLNEYEYYKYNIVTEGKYDLVNNDGVKIKHLSYNYTYGNKTIQLLKKTSQNLTGTNLCTSSNELNLSIWHDVKDKKQKFKTINITDIKYLTTSENVNNTLDYNQINLQRDKNKIRFDDFGLGKEKKHFVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC89</accession>
    <name>A0A0N0PC89_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
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        <property type="protein sequence ID" value="KPJ12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC89"/>
    <dbReference type="KEGG" id="pmac:106713436"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="374" mass="43046" checksum="430CF64C2C6D81DB" modified="2015-12-09" version="1">MFPPTRLKSCLPVMNPMFKRLRPHRPFRQTPYHNQTKVSNTVTNTKWMNLRAIITRWVPLGSVMYVGWCYIRASVNYEVSKVEIKFYEMFPFRITSRLWGRLAACELPTSIRNFVYGTYVRIFNVNLNDAAITDLKYYKSLSAFFTRPLREGARYISPAICVSPCDGVVLNCGPADTDKIEQVKGVTYSLEEFLGENKWSENSDPNYYNSLLKDKNNILHQCIIYLAPGDYHRFHSPCDWTSKFRRHFSGKLLSVNPWMARLIPGLFTMNERAVYIGEWKHGFFSMTAVGATNVGSIEIYSDPNLRTNTKGKRNRVDELNINTSYCKGELFGQFNMGSTIILLFEAPKDFKFEFKSGERVLVGQALTGCAVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCE8</accession>
    <name>A0A0N0PCE8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N0PCE8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="567"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="869" mass="94879" checksum="AB73A5B8334768D9" modified="2015-12-09" version="1">MEPPGTGSSNNGSLAPPGVPNFPPMPPPPGSMGQGNIPPPPMGPPGAMPPVTSSNGTTNIPSGMGPPPSMMGMGPPGMPPPPPPGMGPPGMGMGPPMGPPGMGPPRMPPTMMRGGLNMKGMNMDMGPPGMGPPPNIGPPGIGQGPWDGPVPPPGWGRQNRSDGPPGWDDQQDDGDDDDVEDEDDESLIDQQGLSQPLPSLLTMKIDTPEEFRNKPNAPSGVVLPKALEEALAYKDQRQAALGDEESTETDKEDMPEVPPAPVISTEYDVEEDEGDSDDDNVPEAPLPPIISKQESQPNKSSKNKRKKKKKKAARQKRNESKKVEDEQKNEKQDAKSSSDKENEKAVEIEYVQENIQFHELEPMYRQFHRILEAFKITEKKEEIKEEFDKDAPKSSSKPQEKVQDQFAADDEAVEITEKKEEIKEEFDKDAPKSSSKPLEKVQDQFAADDEAVEKHAADEKERLSKRKLKKLSRLSYLQGKRGIEKPPFDLPDFIKKTGIMEMRASLQDKEETKTLKAKMRERSRPKLGKIDIDYQKLHDAFFKWQTKPRMTIHGDLYYEGKEFETRLREKKPGDLSEELRTALGMPVGPGSQKVPPPWLIAQQRYGPPPSYPNLKIPGLNAPIPDGCAFGYHAGGWGKPPVDEAGKPLYGDVFGHQSSGQDDNEDHDIDRTMWGELESESEEESEEEESGSDEEGGVAASAGTATPGEGLATPLGISSVPPGVETPDTIELRKKKLDSDIEGGDTPALYQVLPERRVGLTAGMMASTHVYDINAANPGKRGASGSAGAAASGGGAAEGVVEVALDPSELELEPEAVAARYERHLREQRPKHKEDLSDMLADHVARQKNKRKRQQNTDSKQAKKYKEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCH3</accession>
    <name>A0A0N0PCH3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C10orf118-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460587">
        <property type="protein sequence ID" value="KPJ13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCH3"/>
    <dbReference type="STRING" id="76193.A0A0N0PCH3"/>
    <dbReference type="InParanoid" id="A0A0N0PCH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14736" checksum="F93A209ED6604025" modified="2015-12-09" version="1">MLGGGAMAALWGGDPAGLTPQLSLEMNRRLQALLEDTLLKNITLKKEIAMLGGGAMAALWGGDPAGLTPQLSLEMNRRLQALLEDTLLKNITLKVHDKDERGRDRMTKIQDHQENIDTLGEEIARLKAEKQTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCN4</accession>
    <name>A0A0N0PCN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein C6orf105-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_04419</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCN4"/>
    <dbReference type="KEGG" id="pmac:106712644"/>
    <dbReference type="InParanoid" id="A0A0N0PCN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="200" mass="23633" checksum="C4FB5143467406C0" modified="2015-12-09" version="1">MEITKPIALPSGCVLLKIRIWFYTLAWLHLVFTAIVSLSVDMSEDKDPRVSAYINIRWKLITCWFNMIALAYFPICLYCDWKEWRGMWHVQRVASIRQLKDYVMTSILFPTTMFADLMFWRIWHKDLSLIAPPKIFTYLPYWAQHSLHTVSMLIMLLDLLLVPRRRPNNLTPGICLMMAFMLTYMAIPVALWRSLDQGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCT2</accession>
    <name>A0A0N0PCT2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460468">
        <property type="protein sequence ID" value="KPJ14585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCT2"/>
    <dbReference type="KEGG" id="pmac:106711297"/>
    <dbReference type="InParanoid" id="A0A0N0PCT2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="779"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="836" mass="93716" checksum="00E92FCCE663554C" modified="2015-12-09" version="1">MASGRLQSVPQGAAHLDTVRSLHQTVVSLRTALEVSKNELQELKEKYEQHSHCLEYADVIEKLTVENHILRRKIIDSGLDDREASENIKFKITSSPTKNVEECVNSQVVTETITTDGNNKATAEKVEAVELEKLYTCSPTEKLENIQEENSKSSITDLESPRPQSDISEGPKSQITVTEDKGVPSYKTKLELLSKFDVKIKVRTLKESCIVSTTTSETDSTDNQKKEDSFSRKESQESANFQFKEKKEHFDNFIDLDGNEINFKTVSKENIKMAVPNEAEVKSKVDKFDVQVRITSEENLVVKESTERLRRKDTLNLDVDDLSLRSLSEGDNSVFSEGGTTPMEPRPPDDREDASGNESEEVDDIELIFTTDESKDISNLQEDLVSIRETEHWVPNSASTVHSTPVLIKFHTLDPDFQPSERPENVENRESSHEGVVGDSLKQKRVSLPNDKEIKHVAFNGKGSLDLPGRGILKICDNKSDNMLYRRSPNASTRRLDSVDSLTCEYNRGLSFDNTKSSSFELGSSMDILHREESVDSFHKTGRFGHRFSMFAETDISKCGISEDDLASNFNIRRNTCPNPFQYRPLPYRGTVRGGKPVTSSRRPVLRESCGPRRESAAQTDMSALPPRWTSDGYLAYKSSSRVVSCPTTVPQRVTSRRPAPPCARAPRPARRHHLYAYVHTKISTLKSHIREYRPWRGSLPDVRNDDTDELLQEAETFLRRSIDNITAAADEPECIHTGQGQPYVPGEARQLRLGHAVKLITPQGRLAVGRVRYVGIAGGSAANSGVVVGAEFSQAQYPGLPPNDGTYRGRRYFLAPPQYTAIFVPFSKVVMAWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCU0</accession>
    <name>A0A0N0PCU0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCU0"/>
    <dbReference type="STRING" id="76193.A0A0N0PCU0"/>
    <dbReference type="InParanoid" id="A0A0N0PCU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="392" mass="43992" checksum="0D4D77874F78E4B5" modified="2015-12-09" version="1">MSDSPSRGLLSGALGPSDFMERPPKRSKSSVTSQFDCLLNVETDFDRYHPLILTKGHELPNFYIKDEHLAIPINTKVVFFCEGGFNKFSDQSVEATCREGKTFEINREIVDYPKLKCKKALQPVTIQEDNCASGKGKLFRIGMSVSPDKNFMEVYRICVDKKFRFLYTKHKIKPWAANVSATGMQIEKWLHSDVLSYNNNEMYDCKRQRQKGAISAILGRALPGNDDECYVARQLINEKDVPPGFPQLLTHSYLNIIPHWNSTATKYWNILEEIIRAETKKRIEQRTVTVITGVNYDVPAGEPQITITDKAGNSNKVPTFLWKSARADTAGWVAEDCASVPVTQPQGDVEGQRGFTGLTQVAKACPRSCHWDCVGGTEGFSGYASDKEENPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD31</accession>
    <name>A0A0N0PD31_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_02475</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the hemolin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460476">
        <property type="protein sequence ID" value="KPJ14370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N0PD31">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD31"/>
    <dbReference type="InParanoid" id="A0A0N0PD31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000405">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1051"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="530"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="669"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="765"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="935"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1321"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1101"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1321"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1351"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1402" mass="153768" checksum="8A9D2CCD88B4659D" modified="2015-12-09" version="1">MAYTRGCVVLCCVVCQPGSVSTHQNLHSRERVHGCHLCGKDFYSRVALKRHQVTHTGEKPFPCPQPQCEKRFTQSNSMKLHYRTYHLKHPYPKRVHFKATADDDYADFTCEARHEALQRDVPMRSTVQLSVLYPPGAPYIEGYAEGETVRRGQSLELVCRSRGGNPPAQLIWYKNGEQIRMAYRTSGRMSENVLSFKADASDNKARYTCEAKNVMISNTLKAEIDLTVLFAPAHVTISGPSEARVGDPVPLSCSTAPSNPAADVKWVVLGKHHKEASNRTVISPEGGWITTSNITVVVEPNRRSVVVVCHGINAQLTENVVSTHTINVLYPPSAPMITGYVPGTTLAAGTVQKLSCISSGGNPLASLTWFKNDKKIHSVSKASDKSVSAEISILTNVTDNQAQYRCEATNSATEIPLFETVTLNVHFAPEAVKVRAEPSELKPGTEATLYCDAASSNPPAALSWWRDGIPVQGLPMQLKKGLHGGTVSTIELKLNVSKELNGAVYTCQATNEALQRSVHDALPLKVLYAPIFDETTQETAVGVENEPLVIVVRADGNPPSIAYTWTKDGLPITQSSYSSSNDRIISEGSMLNMTRLSRHDAGVYTCEAVNSQGAATLNITYMTHDRIISEGSMLNMTRLSRHDAGVYTCEAVNSQGAATLNITVSVHYPASIKSVTQKGIANPNEDAILACTATGNPLTSEHIRWERKGYNMDSRTITFESRNQTSYLTIDRATREDVGNFQCVVDNGIGGETKQDVMLVVKFKPEMDTSPNLVKSATNVGQVGRLTCRCKSAPAPNFTWSKNGAKLPVNTSTKYFAEFHKSDAITYTSVLLINDVTSSDYGSYECGARNDLGFSTTSVKLDITSAPDLVSSLIVTNVTHNSVTLIHAISNALPTSNRQRTGCIEIEYFPLVSIPSSDKSTSLPSFFIRKWWEDLVSSLIVTNVTHNSVTLSWVPGFDGGLPSWFRIRFRKIYDDTYKYEDVSPRNATSFTVTGLERNTDYVFSVMAINKIGQSKYRPDDTKATTLTSSEVGELNVVSTEYVESSDVSKSVTLYVCVTGAILILINAALVACFVFKRRARRMKEQAGQSSKSATIEMYAPSSYNDTMTGETLSSVSEKSETYSQDEGEQPPPIPEVPTMPNRHMLNQTESYLVEDTTLLPPPLDYPPPNYAAYDGEHARTLPHAPHAHRGRDSGHNTLGRSAGKQNYVAAPSPMPPLDGSYFNMASDRYLSYPPLIGEYLQQQSGRTPTPPQQYGAAPVPKPHLMNGALQSSPSHIASPPLSYGLDGLDRQSAGGTLRRQRLEKMAVPPPDVTVLHQGNCNQHSQMSQTPSIKQPQSILKDPSRHKYNAYSSPVSSSTPQTSNQILTVQNLDVPQYGTIRKEKKQNVTIDESYNKRSETHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDE3</accession>
    <name>A0A0N0PDE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDE3"/>
    <dbReference type="STRING" id="76193.A0A0N0PDE3"/>
    <dbReference type="InParanoid" id="A0A0N0PDE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="517" mass="61044" checksum="3B9C2A4F499F8767" modified="2015-12-09" version="1">MDWNEILSDVEDINDPTIYEKVLIAIDDIYCEDEDFMQLLISKLDNMHVTWEQPWYQTSLCLTRCTVANCEDNEKREKFRTTHFTKKECEQIKENWANFIEEYEVPDMLQSFARWKNRDCKNPSSPHEKVRRFVTAYLAQGLERNMHQVYQYVVKHFGTPVKGNYSDVEKKLFNICFYFNEKHAVKNLSLLLGRDPRGIYKQLHQMNEGKPEKKKLKWTLPLATKFVNLLLKYSNGSLEELKYKRFDKSVWLQLESDMDQQYQYLQKSWYNALHVQIFVKQDVKMNRLRKKIIRILRDSPYEVWRDICWKDLPKHFPDAAYPPSAQAHAVASVSGSRAMAPAAASVVLFRVAVAASRGRLSHHKYANNFFETAEVPAYLDDDRFEEIEFSWIKHKKLLKNEPNPIKEKPTNVEVESKKRVEQNRLCNRHIVKGTLSKCDILCLKSVEKKIPNDILLWFANFLMFKDMQSHFMTPKSCLVSEPVNVKIEKQENNINKPDNISQRGKFTYRVIISKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDV6</accession>
    <name>A0A0N0PDV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor YY2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDV6"/>
    <dbReference type="STRING" id="76193.A0A0N0PDV6"/>
    <dbReference type="InParanoid" id="A0A0N0PDV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="29654" checksum="05DB7369561BCF93" modified="2015-12-09" version="1">MLTAVVFVDGAVVSNISKCHGPKMMNQEIMCEVEIGTHGGMVEIDNDDQVGVKYEEIETGQYEEYITDDQYEEVEEQVIGMQHLEEVGNEEVILPGISGEEVLHPVADNPYEPVYTAPPSTSNSRVRGRGRVNTNNTNTIHHLMPIGEVPMGLMEGVNANRSATRRWEQKQVQIKTMEGEFSVTMWATGEDDDDGSNPEPDPDYTEYMTGKKTVIGNEAMPGLDLSDPKQLAEFARPGHKIRLKKPMPESSDRTIASLRLPFLNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE96</accession>
    <name>A0A0N0PE96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase II subunit RPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE96"/>
    <dbReference type="STRING" id="76193.A0A0N0PE96"/>
    <dbReference type="InParanoid" id="A0A0N0PE96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="41399" checksum="51B989B1FC7CE208" modified="2015-12-09" version="1">MNSPQMSRPAAPPATASDVTLSPKAPLSAGFVCSPNIETTIGLPFFHDGGGGLAIVAGLRGSKGVGCGKGIGGNKGLGGNKGVGWNKGFGDNKGLGDNIGLRGNKKLGYKGLGVAGVGVALHIGAKAAGDCGHGSQWPANSNGAPNVHPLIVPVPNANQPKGDPSTTPGANPTQSNGNPLTAPGVNPNKSNGVPSITPGLNGNQPNGDPSTAPVANPVQPIENPSTAPVANPIQPNEDPSTAPVANPNQPNGDPSTAPGANPIQPNGDPSTAPGANPNSTEWSPSTAPGANPIQPNGDPSTAPGSNPNQPNGYPSIAPGVYPNQPNGNPTAAKDPNIPSPAPNVPASVLPVDPIPAHSLPSPTSYCNGKPKISKLGGRRGVDHGLEAALRLGVHVGVAKRIGGGALPSVPKPIKPKLPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF68</accession>
    <name>A0A0N0PF68_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459647">
        <property type="protein sequence ID" value="KPJ20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF68"/>
    <dbReference type="STRING" id="76193.A0A0N0PF68"/>
    <dbReference type="KEGG" id="pmac:106712407"/>
    <dbReference type="InParanoid" id="A0A0N0PF68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="362" mass="40413" checksum="BB83E0F42E33FA86" modified="2015-12-09" version="1">MKDVKDKIYKIFKKQSQSQLQSKAQSSSVEYFHDFVSENVVSLASAISDIKKSEINVKSDDKVEKTVTIGQKENKRKVEIEINAMKNKFDKMLENLKTEMMKEDNKREVIVKDFEDKDSKVKLDLIKDNEDINVKDDLKESHIVKHDDKDDEDEDKMKLKSILLFSMTPQSTTTSLPVLSIEITTTIPKQVTFSSLIKQKSELVISEDETSSTIKEPSTVVIKSTTTEKPSTVIVKSTKIEEPSTVILKSTTTEKPSTATVKSTTTEEPSTVTVRSIRTDKPSEVLDKTTSTKSSSSILPSVLTSTLTVPSPVLNKSEFNLSKTRPESSTVSKTESCKRGSSQCVIDIPVTAIPKSLDIIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFL6</accession>
    <name>A0A0N0PFL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01041664">
        <property type="protein sequence ID" value="KPJ21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFL6"/>
    <dbReference type="STRING" id="76193.A0A0N0PFL6"/>
    <dbReference type="InParanoid" id="A0A0N0PFL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="81" mass="9198" checksum="EA81D6B580BBAF03" modified="2015-12-09" version="1">MMSKKMRGADGEDELREAFRVFDKNNDGLISSVELRHVMTNLGERLSEEEVDDMIREADLDGDGMVNYDGITLTNHNYSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFR8</accession>
    <name>A0A0N0PFR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01028359">
        <property type="protein sequence ID" value="KPJ21182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFR8"/>
    <dbReference type="KEGG" id="pmac:106707608"/>
    <dbReference type="InParanoid" id="A0A0N0PFR8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="11519" checksum="E213857094561EA6" modified="2015-12-09" version="1">MSDSVTVSDGDSGVQVTDSNRGGIHVDGGDYGGVTAVDNSGYGGVSVADNSGYGGVHVVDDSGQGGVNVVDDSGDGGVNVVDGSGHFRTHSAQVTSEDGEGELNIVPDSGFYMPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9Q2</accession>
    <name>A0A0N1I9Q2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460499">
        <property type="protein sequence ID" value="KPJ14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9Q2"/>
    <dbReference type="KEGG" id="pmac:106711668"/>
    <dbReference type="InParanoid" id="A0A0N1I9Q2"/>
    <dbReference type="OrthoDB" id="8191594at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF28">
        <property type="entry name" value="GH28833P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29296" checksum="13580A3777A8C67E" modified="2015-12-09" version="1">MEWLDTKPVIFADKYRIECLSPATFPGALRVIKESFCQDEYVSIGSEVNKNPIAAEELLELCADAALDSVSLVAVEVNTNEVVSVAFNKIQVQSMSGSEKPFFEVFAEERCTQESSRSLIQFMATVDGRCNLFDKYGVDCSLEIMFLATLREHRHKKLGMILCKYSVELAKKIKDGPVGKLTVQDLGPKYSMLKSREPFGTYPKICQAIWTSIGSQKIGKVLNFKVHLTVPLKEFIFEGKPYSERIGDENAFCEVAAFPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFA4</accession>
    <name>A0A0N1IFA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Single-minded-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KPJ12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A0N1IFA4">
        <property type="interactions" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="260"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="558" mass="62729" checksum="3B8D6969109FB70E" modified="2015-12-09" version="1">MSYVRTACRREQRPLSIDATAIMKEKSKNAARSRREKENSEFLELAKLLPLPSAITSQLDKASVIRLTTSYLKMRQVFPDGLGDAWGAAPPPLQPRELSIRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHQQDHEEMSAVLSLQHPHSYLGHQMPSLGYPVGGTWGPTVDVECERAFFIRMKCVLAKRNAGLTTSGYKPPFTTRRFGEATAPLGLVAVGHSLPPSAVTELKLHSNMFMFRASLDMRLIFLDARVATLTGYEPQDLIEKTLYHFIHGTDVLHMRYSHCTLLAKGQVTSRYYRFLTKSGGWVWMQSYATIVHNSRSSRPHCIVSVNYVLSDIEEKHLILNIDQGPPKLNTEVQTPTHIPTSTSPHIHARTDKINHIQLNESDFSTDSSGGYNYPEYTLPVVPYETHDEYQTQNGPYELFYNENYTEPEILPNNYVYPQNQRPFSASSSSCSSIESSEVNQQYNYTNLISFYGHNSQNQNGRPLQGNFGGNFSKMAPSPTVQDGGYTSVIVDNTQQFHHHSGAVNEFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFR1</accession>
    <name>A0A0N1IFR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_02795</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A0N1IFR1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
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    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="440"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="760"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154477" checksum="CE60585EDD58C1C8" modified="2015-12-09" version="1">MSHDGYKNENSSTEIRSAGVNAAYIEKLVGSSNFHTWKFDMELYLTDDDLWKYTQVSPQPEDVADVRRDQKARARIGLMVDQRCRTLIRKTKTAKEAWEALSKAYEDKGINNKCRLLGRLVSMRLEQFQTVEKYVTAILSVSQQLSDIGKDVDDEILATLMLQGLPKKYEPLKMAIENSNITITTDYVKTKLYNLSDESTPSTSFQQDDSALTASKKKWKGKFKANQKTKPIKCFICEGNHKATECPDNPNRRKNCSATANVFATSGQGSLADWVIDSGASSHMTNEKGWLRNYVAYESKREIACADGGKVYGLGVGDVVDVDGSIRVRDAMYAPDLATNLLSVNTLVKRGRVVVFSNRGCEIYKSDDCKVNGSVVAGDCWHLVSSMQKDDQLMLWHRRMGHLGVSNLKLLRDKLADGVSFQNSKNNLECVSCLMGKQTRQPFPKRKVKRAREVLELVHSDICGPMSVNSMSGYRYFMTLIDDKTRKTFVYLLKNKSEAIEKIKEFKVFAERQTEKKLKSIRTDNGKEYVNNDMKSFTKKYGIVHQLTVEYTPEQNGVAERANRTLMEKARCMLHEAGLEKHYWAEALVYAVFLKNRSPTKALKDKTPEEAWTGRKVNLGFVKVFGCKAYMHVPDQKRRKLDPKSKELILLGYCENSKAYRLLDPVSGNLHKARDVVFFESTLASRKQPSSEILTDEQNSASHQRPSPEFTVVPLTSTQSMEEVVCGEETEDGCRNETARHLSGNRGGVIMPESEEIRAEIEQDRTGAVSSVTEETEDRDDTEQWYLSSDAAVSEENNHRDDQTDDQTDARRYPMRNRKSRQFPDHVLYQAVLSEESGFGLEEPINVREALAGTDSLLWHEAIKEELDALHKNQTWQLVKREPDQNVIDSKWVLKVKTEAGNKKRYKARLVARGFKQRGGVDYFETYSPVIRHSSLRLLLAMAAENKLKIDQMDVKTAFLNGYMEETVYMKQPEGFEEKGKEDYVCLLKRSLYGLKQAPRAWNQRLDSALKQLKFTQLDNEPCVYMRRSQHRLIILAVYVDDLLIFWNNKAEMQQVKKELRETFEMRDLGKADLFLGMRLQQTEDDITLDQEGYIEKILARFDMQDCKPVSTPLIAGYRLTKPVETNYEPPNNIPYQELVGSLMYLAVCTRPDVAFAISYLSQFNSCYGEQHWQTLKRVLRYLKGTKSLGLVFKQSGRYLEGFVDADHAGDITDRKSYSGYIFKFGSAPVSWESRKQTVVALSSAEAEYISLSNAAREAVFLKRLFGEITGVNKTIKLSSDSQSAIAMANSEGSCHKRSKHIDVRVHFIREALRNKVISLKYLETESMVADIFTKALPRGKFEFCLRGMGMSLCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG62</accession>
    <name>A0A0N1IG62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460041">
        <property type="protein sequence ID" value="KPJ18354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG62"/>
    <dbReference type="KEGG" id="pmac:106721340"/>
    <dbReference type="InParanoid" id="A0A0N1IG62"/>
    <dbReference type="OMA" id="DYRTYAN"/>
    <dbReference type="OrthoDB" id="6417212at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="151" mass="17879" checksum="E959C590FFCBCF80" modified="2015-12-09" version="1">MTSERAIPHLRDIFSLNQQYDGKPYDDDDTNKKTAKKKKDDYRTYANGDVKTLERHLSMKKTIRKKIMRDLQQAFVEDPNEFKVENTSPEKLKAELSAEAVKIEKNVRKNDPTFLDMLRGETRGEETREEQPPAEKTSFWRRLTMKNKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGK5</accession>
    <name>A0A0N1IGK5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459939">
        <property type="protein sequence ID" value="KPJ19189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGK5"/>
    <dbReference type="InParanoid" id="A0A0N1IGK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28157" checksum="CFD7DF3768A18543" modified="2015-12-09" version="1">MNHIDTGRVIDEVRIRRCLWDPADDFYKNKDAKNKAWEEIGKELCGENFNTDLENEVTESLSDNQSIVSEDLTETATSANNLSTPSQLHRPQENTENSQNKWNKRSGMNKRKSEQSNFENELITLLNQNTSNLNPDDLSFFESLGPILSNLSAYQKLQFRAKVLELLIGISAPTTTTPSFSSPENNVNPSVNANSTYNYTTQTLPLHNYTFAYATTSTPQQQLYESAVELSNVVSPTGDNNSNYPDNEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH05</accession>
    <name>A0A0N1IH05_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH05"/>
    <dbReference type="STRING" id="76193.A0A0N1IH05"/>
    <dbReference type="InParanoid" id="A0A0N1IH05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF138">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="145" mass="15880" checksum="88CDB2BFC4EC9AE8" modified="2015-12-09" version="1">MVTATVYCAPAPLRYAALAVYCLGSLLGLYKAMRAWSPWERRLCFAAPFCMRLLLAGARAARLGGGDPHAILHVFLQDAVSLGGGVIGAMHIPEKWFPGAVDRCLNSHNIMHVLVVLAVYSMHQVTTLDLAWMSRVDCHAPLRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH26</accession>
    <name>A0A0N1IH26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chorion peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH26"/>
    <dbReference type="InParanoid" id="A0A0N1IH26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="539" mass="61160" checksum="E32FF5D702DAEC38" modified="2015-12-09" version="1">MTPNAFMTCLEDQDIRVTDVSYCKPYKTPYIKSKYRSIDGTSNNVKHPGWGRAGAPFSRIAAPRYSDGIYAMPLAVSGRPLPNPRTLSTQLFADRPVASRTLSYMNMQWGQFVTHDLLSQAMEVNDEGGIQCCYGRGRDVLPQEWQNDKCIPICIPDDDPFYRQHGVRCINFVRSVTTPRDDCSLGYAEQMNTVTSFLDGSPLYGSDPALASKLREINGGRLKEKTRPGCKRGFLPTADSKTCDLRNASDPCYLAGDRRVNQTPTLAVIHTLLLREHNRVADILSSLNPLWTDEKIYQEARKIVIAEIQHITYQEWLPLNFVESSCESLDDIVRGILMQSSAESDPYCTREITNLLFKLNNQWGMDLVAMDIQRGRDHGLASYNDYRETCGLKRAKSFQDLTGEIPQDRINALSQIYESVDDIDLFVGGIMEKSVKGSILGPTFQCIVAEQFYRTRIGDRYFYDNGEMPHSFTPEQLKEIKKASMARLICDNTDGVSYVQRKAFEMESVHNPKYSCTDYDAIPFVDLTAWKRPILELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIL7</accession>
    <name>A0A0N1IIL7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_02344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ460210">
        <property type="protein sequence ID" value="KPJ16586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIL7"/>
    <dbReference type="FunCoup" id="A0A0N1IIL7">
        <property type="interactions" value="1648"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IIL7"/>
    <dbReference type="InParanoid" id="A0A0N1IIL7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="373"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="690" mass="77064" checksum="A40101200453757E" modified="2015-12-09" version="1">MAAVSNLYDDRRGGRGGGRGMSRGRGGGRGGSRGGRSSDRSEERGSRFGSSVRGRDGGRGGRGFGGRGGGREEFRNFKNDQPGGNLRKIRWESITLTPFQKNFYVPHPNVQRRSPAEIEAYRSENQITVKGRDIPAPSMYFEEGGFPDYAMKEILKQGFPHPTPIQAQGWPIALSGRDLVGIAQTGSGKTLAYILPAIVHIINQPRLLRDEGPIVLVLAPTRELAQQIQQVATDFGQNVQVRNTCIFGGAPKGPQGRSLERGVEIVIATPGRLIDFLEKDTTNLRRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVLMWSATWPKEVQNLAEEFLHDYIQINIGSLSLSANHNILQIVDVCEEWEKNEKLLTLLNEISSEEETKTIIFAETKRKVDDITKTINRAGWRALAIHGDKNQQDRDYVLSQFRMSTGGILVATDVAARGLDVEDVKFVINYDYPNNSEDYVHRIGRTGRSQNTGTAYTLFTPSNSAKAKDLMCVLQEANQVVNPRLLELAQCGMGFKGKYGRNRFRDRDDNDRGRSDRGRGRGRGGRFGDRGSRWDENSSNNYNQGTSFSREEGYNTRQSDSRQFANREGGGFNREGGGFNREGGGSFRGRGGGRGRGRGFNHGDQSYQNQNFNVPPPTSYYNISQLIRVKQMNWFSSCQLRVTACGSSTHIVIVNLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IK01</accession>
    <name>A0A0N1IK01_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01064669">
        <property type="protein sequence ID" value="KPJ21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IK01"/>
    <dbReference type="STRING" id="76193.A0A0N1IK01"/>
    <dbReference type="InParanoid" id="A0A0N1IK01"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="86" mass="9470" checksum="AE0997C6AF1D1470" modified="2015-12-09" version="1">MLDFALLGLTVKEAPPPEPEEYCWSDLFKSLWAGQIGDVTLTFPLLGRGLLSIVQYGAFGVQLLRWWEAKASPVTSLPLPTPPQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IL44</accession>
    <name>A0A0N1IL44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I inositol-1,4,5-trisphosphate 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01062073">
        <property type="protein sequence ID" value="KPJ21630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IL44"/>
    <dbReference type="InParanoid" id="A0A0N1IL44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039737">
        <property type="entry name" value="INPP5A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997:SF2">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997">
        <property type="entry name" value="TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="120" mass="13859" checksum="CEBAFA0122336D9C" modified="2015-12-09" version="1">MARKVFTKFYHFDSQPAQQSLLYEWVSSPGEMPRPYRRKASSGSNSAFSLMSGAGGLILIFFPVSHFSYMERMRRCKWSRKGFLRTRWLLRGTAVEFVNIHLFHDASNLVAMEPFPSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INH1</accession>
    <name>A0A0N1INH1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="10">TDO</shortName>
            <ecNumber evidence="10">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophan oxygenase</fullName>
            <shortName evidence="10">TO</shortName>
            <shortName evidence="10">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Pigment biosynthesis; ommochrome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="10"/>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INH1"/>
    <dbReference type="FunCoup" id="A0A0N1INH1">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INH1"/>
    <dbReference type="InParanoid" id="A0A0N1INH1"/>
    <dbReference type="UniPathway" id="UPA00271"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:L-tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006727">
        <property type="term" value="P:ommochrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3810:FF:000001">
        <property type="entry name" value="Tryptophan 2,3-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 10" id="KW-0349">Heme</keyword>
    <keyword evidence="5 10" id="KW-0408">Iron</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0823">Tryptophan catabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="450" mass="52231" checksum="0B05C9D9F3DC2533" modified="2015-12-09" version="1">MDDSGAQDGSHLGNEAGMLYGEYLMLDKLLTSQRMLSAESSKPVHDEHLFIVTHQAYELWFKQIIFEVDSVRALLDVEINFFNWKVLDTGEELYFWKGKNIPERVRMAKDTIIEEYISDDGLDRTVDSAVVVSVRQGKEPAVFKKLFPDWDDDMWELLVDQVMILETMTPLDFMDFRHYLRPASGFQSLQFRLLENKLGLKQALRVKYNQNYQTVFGDDPEAMESLRKSEDEPALLALIERWLERTPGLNTHGFNFWGKFQNAVDTMIKNDINEAMLEPNEVVRKHRLQDAENRREIYRSIFDPSVHDALRSRGERRLSHRSLQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLLPRSLIPPLDDGMKRSLNLTWGDNIKENGQNGQNGQNGLEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP18</accession>
    <name>A0A0N1IP18_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP18"/>
    <dbReference type="InParanoid" id="A0A0N1IP18"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7501" checksum="8C28969E6A9A4C46" modified="2015-12-09" version="1">MLYVLEHGLHCEIRPVFDPKISPRNHIIIGRRITQYNLNHTREQTSVVCITVRVLQEATGCTTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP77</accession>
    <name>A0A0N1IP77_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460675">
        <property type="protein sequence ID" value="KPJ12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP77"/>
    <dbReference type="InParanoid" id="A0A0N1IP77"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874058" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="39" mass="4064" checksum="F1C837916657AE6F" modified="2015-12-09" version="1">MSPFAFLLLCIQACLVQPDSVWATLTDGLVNVAAATDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPH1</accession>
    <name>A0A0N1IPH1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="13"/>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPH1"/>
    <dbReference type="FunCoup" id="A0A0N1IPH1">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPH1"/>
    <dbReference type="KEGG" id="pmac:106710266"/>
    <dbReference type="InParanoid" id="A0A0N1IPH1"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ15615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="35459" checksum="73E83E44477C495E" modified="2015-12-09" version="1">MSKIGINGFGRIGRLVLRASIEKGAQVVAVNDPFIGLDYMVYLFKYDSTHGRFKGTVDAKDGYLIVNGNKIAVFSERDPKAIPWSKAGAEYVVESTGVFTTTDKASAHLEGGAKKVIISAPSADAPMFVVGVNLDAYDPSFKVISNASCTTNCLAPLAKVIHDNFEIIEGLMTTVHATTATQKTVDGPSGKLWRDGRGAQQNIIPASTGAAKAVGKVIPALNGKLTGMAFRVPVANVSVVDLTVRLGKPANYEAIKQKVKEAANGPLKGILGYTEDQVVSSDFIGDSHSSIFDAAAGISLNDNFVKLISWYDNEYGYSSRVIDLIKYIQSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPP9</accession>
    <name>A0A0N1IPP9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_04820</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPP9"/>
    <dbReference type="FunCoup" id="A0A0N1IPP9">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPP9"/>
    <dbReference type="KEGG" id="pmac:106710252"/>
    <dbReference type="InParanoid" id="A0A0N1IPP9"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="271" mass="29332" checksum="20381054E433034C" modified="2015-12-09" version="1">MANLISPEGKTFLVTGGASGIGKQCIETFLREGAKGIAILDVQVAVGQELAKQLNKTYPNKVIFIKCDVGDEKEVSEAFEKVLGHFKQLDVVMNNAGIMVDSPTGWRKACDVNWQGLVSCTLKGLKHMRKDEGGVGGTIINVSSIAALYKFRFLPIYNGSKMAVLHFSQSLAGGPFYEKTGIRILTVCFGATETALLQGLEDRTLDDIGAKEILVVNSQKHQKVESAAAGVLKMFKEGANGSIWLSIDDKPAKDITPVIESGFKEFEKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQN9</accession>
    <name>A0A0N1IQN9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myrosinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01012830">
        <property type="protein sequence ID" value="KPJ20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQN9"/>
    <dbReference type="InParanoid" id="A0A0N1IQN9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="163" mass="18398" checksum="C50AB9D5153ADFD3" modified="2015-12-09" version="1">MVCPQRYFQTATTYGSSRSERITITSMGVDEHLGVPAARGWTNPLIADYFADYANYVFSLFGDRVKTWITINEAISVCDFAYNSGIIAPGIQEPIYGTYLCNKHILIAHAKAYRIYEKYYRPSQHGKVSFANNLLWIEPLTPADEELAELGLQHSVSLNDHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH13</accession>
    <name>A0A0N1PH13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing adapter protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461068">
        <property type="protein sequence ID" value="KPJ09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH13"/>
    <dbReference type="STRING" id="76193.A0A0N1PH13"/>
    <dbReference type="InParanoid" id="A0A0N1PH13"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="935"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114342" checksum="FBAD505FF8A44ACB" modified="2015-12-09" version="1">MQPTNLRRNSKMCVKSTNLHWATVAPQWERIAALCADYSVPVDCVSAGPAPRPSSFHEISAPKVEFLEAYCTPKDTARRSPPRGRRSREPRRSPDATQWRHEARRQHDFESNRRPYDYGSGRHYREYDDDSARRPAFDAESARRRADYESARRTDFHLSTPGARRSPESAPEGSVDSPPEPAPSAPLRQDRQSCHRSQPYYESESSSGDRSTTTDDEEEFGEFDPFATAPSLHSPDSGRSDPRYANAPRRNPSPYYYGDLFKTAAPPPAPSAPTTASSRGSRYRKSASLDAPHVAPRPTLPKRFSVAEDGFRELDRSSSSSGEGAWMPPRRRGRDAAGCACAASEHVEERASRSVFYVPAPLPRWPQEMTARQIYETAFDCKVARSDDDLDDFDRVSNHPALLQAEERKVISSASSAFEAVERGEPDYKGRRKVTMKTDSVRRSKIPTIRQKKENENNASALSEELEKVHIEEEGRNSSTSQLPLRGYTPSPPSTAPLPTKFQQKDGSAMNSIKSAPNLPQSQPAHPRLKDLRLPVKSLRGRDTPPSSDVSMADVKGSGSTDLDIGQRLRDSSRESREGDDERGQTKDGIFLEIKGRPTSDSDTSKSNRYMGPKGVGPIMEFKGRPSVARPRRKYSSTESMATSSSGGSMESLRSSNSEGDRSTTSSESRHSSSLSSHSSDSGNVPFTKSLHHMQLSGFGHHPTKLHILSPISDKSSQEPGSETSDNNKNNNSQKVSPEDLETGNASLMTTDIAPKIKRRALQNKNLLNLSFRHSVAGDTEIQGSDSGISIHSREGVDSRNAFINFKNSSSVEEEKKNEDVDLSDLPFDMPKLRRRRAEAEVDLRTLPFDMPKLRRKLRGQSLQLNNDFGEAISNASSSQSVQDLNQGNKHRAKLTLNFDGSGESGGKGLHLNLGPIAPPRDLIDASLPLDRQGWYHGTLSRVEAEGLLRDANEGVFLVRNSESAKHDYSLSLKSTRGFMHMRICRGAEGYTLGGAATAFPNVPALLRHYVTAQRLPVRGAEHMALSTPLPAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHI8</accession>
    <name>A0A0N1PHI8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide deformylase</fullName>
            <ecNumber evidence="7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_02071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="7"/>
    <dbReference type="EMBL" id="KQ460864">
        <property type="protein sequence ID" value="KPJ11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHI8"/>
    <dbReference type="FunCoup" id="A0A0N1PHI8">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHI8"/>
    <dbReference type="KEGG" id="pmac:106714317"/>
    <dbReference type="InParanoid" id="A0A0N1PHI8"/>
    <dbReference type="OrthoDB" id="276063at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.45.10:FF:000003">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001159">
        <property type="entry name" value="PRK00150.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="216" mass="24390" checksum="D4C810C4781E1D14" modified="2015-12-09" version="1">MGLIRKTLNWYARLSPSRGKTSPPYEHVVQIGDPRLRKTSEPVPIDKIKTSEVQKVIKTLEYVVNKYGSVGMSAPQIGINMRIFVMKLTAQQVSSFPAEIVKMRGISVVPLTTFVNPTLKVVDFIKVVHPEGCESVRSFSAEVARYKKVQITGYDQNGEPLQRTYSDWAARIAQHEMDHLDGKLYTDIMDRKTMCCVCWEEVNLSKGKVAIPFAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI88</accession>
    <name>A0A0N1PI88_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI88"/>
    <dbReference type="InParanoid" id="A0A0N1PI88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="738" mass="85994" checksum="5C3DC78346F335E7" modified="2015-12-09" version="1">MDDAKCEYYRAINKMLQVDCQDKVITNPVIKAEVDELLLDLTIKESRATRQCLPDISSYTNCNKHNLCLGCTRCSCSAAGNWECRRWQQCRQQSPLEVDHHLLVELMEYIDDSSRSIRTKAKRSIHTNVSPIGTEKEENFTSQEISSLINGFNNTSDNKQAGIDNVLNTADMEMDAVTEILELMNATEKNESLDQTDLDFDDLFPEYYNLSIGDAAKLLLPMLKNHTEDILDTDYIEIPDENVTEIDKGNIEKILDFSNLDANAKKTPAMREAYDLFERQSVRVVKRQIINTTRSLRNQVLLNNSKRSIQDLTDNVLHPLLAFINTKRNELQELENMRDYLQEYIRMYIRNETFLKINKTLLENLTKTYVAFYKMEILPDIQKTSVQNKLLSLDDYESKLERDIYEVISDIIGIQEHSNYKDLPENLNILIQAMKYYIHKQGKVHVMREFQRITENNMNMYKKFIELNSNEFAVSSAPSVIKQILIVIDKEMPRSNALAPLSTGAKKILNRLVNYDFGEKYNLKNRSILKPQYNMANDLKDVGIKWYKMTRGIASSHLSDRLYSMKLLHLEISKDIAKINDALTFIQNSQTRRFMLFDKDTSERYASRIGEDIKIVYVKLQEILKQQNEDNVKKIMPITVTTRKQKAKKKSFLQQVKKILKQSKKDFVKVFRSNVKDDLSEQIQNIKRQKDTKGKLNRIKRSSTAFNKSIRRIKNIIPDYLKRKFNGAKNFKTVTKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIA8</accession>
    <name>A0A0N1PIA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline-rich protein PRCC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460393">
        <property type="protein sequence ID" value="KPJ15382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIA8"/>
    <dbReference type="FunCoup" id="A0A0N1PIA8">
        <property type="interactions" value="1736"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIA8"/>
    <dbReference type="KEGG" id="pmac:106710465"/>
    <dbReference type="InParanoid" id="A0A0N1PIA8"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="378" mass="42220" checksum="7647E6F45F81AD77" modified="2015-12-09" version="1">MALVAYDNSDSSDYEDDDQECSPVLLTKSVEDQVTKPSTSQSINEKELEIDNDNSLFNALPQPTKKVSGIIEEEDEFLHKKETASIAVKPKSKITVPSLSDFKDVTDTVPIAKPRAVNGKKSGLLSILPQPKNGSISIKSTKSLIPNVLRQNTGSSSIKKKEPLPTQIKKAKSDTNTISKDSDESDNDEVQNDFFSINKPILIEDIPLQNEDTENLSESKITKEPRSIESYFKKDVDNVEVEPGLSSYNQMETESVVSLDTASSTQSDDSNLILDEEAILKLVGARGKRKREEIQIVDFNQQEVLAEARQLLLKGLMDDTSKRVSASKKKGNEPTNMQKRKHQITYLAHQAKANEVELQNKWANNRMSKRQTQSKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIS4</accession>
    <name>A0A0N1PIS4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIS4"/>
    <dbReference type="InParanoid" id="A0A0N1PIS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="11726" checksum="93E8716440AAF67F" modified="2015-12-09" version="1">MPSAGLPSSKKCLLRFLVRRQNKARQPSGSIISVRCSGKVTRQRQPARSVCRRHGGARAPRSKSSLAATLTARVAAPGPPPPAVPVLRPQTALVDKCLRAKLPERASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJX8</accession>
    <name>A0A0N1PJX8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044779">
        <property type="protein sequence ID" value="KPJ21428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJX8"/>
    <dbReference type="InParanoid" id="A0A0N1PJX8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9441" checksum="857A789AAB521523" modified="2015-12-09" version="1">MDKLAAVNSQLNPNSEESMREEAIIASLLGGAIQDMDEGVKKFQKGIGKHGKFYKLTEVPLKDWELEETYEEVTIQTDKGDKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKA4</accession>
    <name>A0A0N1PKA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01013882">
        <property type="protein sequence ID" value="KPJ21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKA4"/>
    <dbReference type="InParanoid" id="A0A0N1PKA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11747" checksum="97711FB719A4BEE2" modified="2015-12-09" version="1">MVFQINKLQRPDAADKELSYSYKCECLDEGLKVETGREELKKEREIMQLVAGLQLGPDEMERREMPPHMIRSRHGPRYDNYTFFGFEESPEIYIASGGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL87</accession>
    <name>A0A194QL87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL87"/>
    <dbReference type="KEGG" id="pmac:106719747"/>
    <dbReference type="InParanoid" id="A0A194QL87"/>
    <dbReference type="OrthoDB" id="6624851at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="214" mass="23721" checksum="D14D6C94BDF0F3D4" modified="2016-10-05" version="1">MEKPKEAKKIRKPYEEIGAIFNGNEVKIRVPKSTTKPPKLTSSQLKLQQHCTCEDDQSVCSETCGLPGQSVGDGRAANLFNIQVPDDICESLTHRTAMNSEVVYSTAEKHDTLCNVCNVTPKDAPKGVQAQKVLHPDKDVFILQIGKQTDEPNRTGNIEVELITPRAPAKLKPATHACKQIQCEDDDIPYCVPCRTCRLPAPRKKRKRAGCCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLB6</accession>
    <name>A0A194QLB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLB6"/>
    <dbReference type="KEGG" id="pmac:106719749"/>
    <dbReference type="InParanoid" id="A0A194QLB6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="238" mass="27840" checksum="6B2BB891F8D8EDAC" modified="2016-10-05" version="1">MEYTHPSEPHSNVHKFSGYHPDKYDLSGISLTVRTDESLTPQRPPCLTQRTVGMYLRPLTRELDEVAPKPYIDDLSNIVIDKMLQKDKAFWVDKPGANAYTLHDAYYNYEMTTERIKPHHQDVFPRAYSYDLDCVKYRRLHACDGFKSSSQENTKPAAAYCRDCNGGETKESQSGIDNNDITLGRWRQYPNLNTKLPPEKVQELMDEVGRPFKHEACNWYYRKYPTRKFDGILRRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLD6</accession>
    <name>A0A194QLD6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Membrane-bound transcription factor site-1 protease</fullName>
            <ecNumber evidence="24">3.4.21.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Endopeptidase S1P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">RR48_14086</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">Ya'a_city_454_Pm</strain>
            <tissue evidence="34">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.</text>
            <dbReference type="EC" id="3.4.21.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.112" evidence="24"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLD6"/>
    <dbReference type="FunCoup" id="A0A194QLD6">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLD6"/>
    <dbReference type="KEGG" id="pmac:106719754"/>
    <dbReference type="InParanoid" id="A0A194QLD6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000008">
        <property type="entry name" value="Membrane-bound transcription factor site-1 protease preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055143">
        <property type="entry name" value="MBTP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057060">
        <property type="entry name" value="MBTPS1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057032">
        <property type="entry name" value="MBTPS1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF7">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23001">
        <property type="entry name" value="MBTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23094">
        <property type="entry name" value="MBTPS1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23090">
        <property type="entry name" value="MBTPS1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 27 34" id="KW-0645">Protease</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 27" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 29" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264455" description="Membrane-bound transcription factor site-1 protease" evidence="29">
        <location>
            <begin position="20"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane-bound transcription factor site-1 protease-like N-terminal" evidence="31">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="30">
        <location>
            <begin position="197"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 third" evidence="33">
        <location>
            <begin position="472"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="32">
        <location>
            <begin position="600"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="921"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF23001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF23090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF23094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KPJ06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110371" checksum="B2FDF7E6A409FCCA" modified="2016-10-05" version="1">MGTHLLLFLLGLRITIVFSAEVTDSVLCNATSSERVEYEFSTDVVGSEHIITFRGYFLRRARENYVTAALNNAGISNWTIVQRENPAKDYPSDFDVIVMNDGDRAALDALRDHPAIRRVTAQRIVQRTIKYVQEDTNCGPNGCLYSGWRNHRRRALHSIRKPRENEGYSSRKLLRTVPRQITSVLKADLLWSLGVTGEGIRVAVFDTGLARHHPHFGRVRERTDWTGENTLDDALGHGTFVAGVIASRADCLGFAPDADLHIFRVFTDNQVSYTSWFLDAFNYAIMRKIDVLNLSIGGPDFMDHPFVDKVWELSANKVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIGFDDRIAKFSSRGMTTWELPNGYGRMKPDIVTYGSGVRGSSVTGGCKSLSGTSVASPVVAGAIALLASGVPRQHVTPAAVKQALCVTARRLPGYNMFEQGHGKLDLISAYQFLREYTPQASLSPPYMDLTECTYMWPYCTQPLYYSAQPTIANVTVVNGLGVAGDVKEVTWHPHLPHGGLLSVSADYSPILWPWSGWLALSFTVTQEGADFDGIVEGHVNITIESHDETKERTMINTTLMLPIRARIIPVPVRSRRLLWDQFHSLRYPGGYFPRDDLRAKHDPLDWHADHVHTNFRDMYRRLREHGFYLEVMGTPLTCIDTSLYGALLLVDPEDEYFPEEMAALKKAVDSGLSLLVFADWYNASLLRHVKFYDENTRQWWIPETGGANVPALNDLLSMYQIALGDRVFEGAFKLGGHPMYYASGTHIHSFPKHGVLITAQLSDQGQQIMSGEKGGGTAAAGADNTVDVPILGLLQTDNGNREFTNDTVDKLPKAGRVVVYGDSSCLEGGSSRPCHWLLLAALQYALGGHLPASLRDAAAARRRDVHLIPSELPQRAEGGRLHMYSRVLAADGSGPRPLPSCAPPSPLPPQPVTAPPAARTLAPRHAPTDPRSIGAPEVEGTEPAPRAWRGAGAAPSRSHPEVVYEPPIYILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLS4</accession>
    <name>A0A194QLS4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_14053</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QLS4">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLS4"/>
    <dbReference type="InParanoid" id="A0A194QLS4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05052">
        <property type="entry name" value="PTKc_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000542">
        <property type="entry name" value="Tyrosine-protein kinase Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="318"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="617"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="774"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="975"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1339" mass="146878" checksum="E09370F2444F43C4" modified="2016-10-05" version="1">MGAQQAKERGTAIGASMRSGRSRPRPPRDPRILGSNIFTEHSEALRQSRPLPHIPDLPDGEGTSAVPPAPQLLETANRWTSKEDLLAHQEDDDPQLFVALYDFQAGGENQLSLKKVDLNGAALEWLSLENCTDVVYSKPVEESKPCVQLTAFKQSTAVHREQVRIMSYNKSGEWCEAHTLSGGRVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDSDGKVYVTSESKFGTLAELVHHHSVLGDGLITQLLYPAPKRNKPTVFPLAPPDEWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEAAIMKEMRHPNLVQLLGVCTREPPFFIITEFMSRGNLLDYLRTESREHIDAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPRVDLAEVYHMLEKGYRMECPPGCPAAVYELMRGCWQWNPADRPTFREIHHALEHMFQDNSITEEVEKQLQEGGGHGIGSQMSVKKSSVGPVSSIAMAETRAVQMRRPTNRRGKQAPTPPKRTSLLSSCSSFRESQYAAEEHAGHDDLASLNGGGRGGGREASSEGSLAEATPDTDESAGASAPGALGLPADCRHRPKRRHHHAHPQYHDFQDLEPLRYTGVVVAALEVHNVKRAINRYGTLPKGARIGAYLESLRQSGGGTGAAACSSAPREPAQDEARSLSPRTARAQPHMIRSNSSGGVTAPAPASPRASRAAQPLRTFNSPAKPRPRLAELEFPPPPSDLPPPPEDSVQPPPPPPPPECCRDAGTNTADRLDEGAPERTDKDEKPAKQVMKELLELKLVAEIKECADKKKQKVEETDPTLEVIEMHTSFKDPASRLVSELSESLNMEVLRIGERRVEPKPAQSGKETVSPIDLKASLRKTTYSNNVEKKPDETKTNTNFKSQLKKVGTNKFNNASKEGEESGKSIIDFKSRLRKVDNGNPPTNGTMKKVEQTSPEDSRKDVSTKSDDSDKKRSESGSVDTSGGDEEDKRRSTGSISSLKKLWEGKESDERSGHKMRPKGEESEEASPEDRSAAAGGRGGGAARREDKPTVASKPSMRARPLAKCGIYATPLAAPDADSDVNSLASLRASLEWCTNEVRRGCGGGGGGRGSLWRLQTSERLAQLGAACAACAAAGGCAPQLRVKLRAAAARLENEARALASPHSHDHHLADGVEQALRDLAAIVHSRHFVYVIVNSRYAFFMLLIHRPLIELRPGNVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLU0</accession>
    <name>A0A194QLU0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLU0"/>
    <dbReference type="InParanoid" id="A0A194QLU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13757" checksum="6109D133836AD726" modified="2016-10-05" version="1">MFTIRKLSFKDLTSLITRTSDDVIDDDEEDNISLAQLAQNLRPALSTTERHGVIDVDQSIAICAPATEDDIVREVQEENENEQEDSEEQFTVPTLIDGLNAVSVLRKIVLFNEEFHMHAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMB2</accession>
    <name>A0A194QMB2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_11714</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMB2"/>
    <dbReference type="FunCoup" id="A0A194QMB2">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMB2"/>
    <dbReference type="KEGG" id="pmac:106719632"/>
    <dbReference type="InParanoid" id="A0A194QMB2"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ06667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="415" mass="44154" checksum="B73A2DFA4AE0370A" modified="2016-10-05" version="1">MALNKLSIDALNLAGKRVLMRVDFNVPLKDGVITNNQRIVAALDSVKFALDKGAKSVVLMSHLGRPDGQANLKYTLKPVADELKKLLNKDVTFLKDCVGSEVEAACADPPTGSIILLENLRFHIEEEGKGVDASGAKVKADAEKVKAFRASLRKLGDVYINDAFGTAHRAHSSMMGEGFEQRASGFLLKKELQYFAKALHEPERPFLAILGGAKVADKILLIENLLDKVNEMIIGGGMAYTFLKETKGMSIGNSLYDGEGAKIVGKLLEKAAKNNVKVHLPVDFITADKFDENAQVGTADVDSGIPDGWMGLDVGPKTRELFADPIARAKVIVWNGPAGVFEFEKFAGGTRALMDCVVKATNNGAVTIIGGGDTATCCAKWGTEDKVSHVSTGGGASLELLEGKVLPGVAALSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMM8</accession>
    <name>A0A194QMM8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMM8"/>
    <dbReference type="FunCoup" id="A0A194QMM8">
        <property type="interactions" value="1954"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMM8"/>
    <dbReference type="KEGG" id="pmac:106720171"/>
    <dbReference type="InParanoid" id="A0A194QMM8"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000002">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="322"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="608" mass="71114" checksum="B21CA8246E497492" modified="2016-10-05" version="1">MVSKKKKKYSSGEGAQFMTRKAALKKLQLSLKDFRRICILKGIYPREPRNRKRAQKGAGGIKTLYHTKDIKFLLHEPIIWKLRDLKVFQQKIRKARATRQFGQMRKYLRDYPSINIDHIVKERYPTFVDALRDLDDCLTLCFLFSTFPSIKKVPRDQSLLCRRLSVEFMHAVIAAKALRKVFISIKGYYYQAEFEGQTITWIVPHHFSFQPQSKDEVDFKIMSTFVEFYTMMLGFVNFKLFHSLNLVYPPQLTAGFTPETDKDLVDEHAYVAERIAALNISVAKIAGSNEVEELPEIDIFQTEDGDPQKLEEAKLEVEKVKNLKTMFKGLKFFLNREVPREPLVFIIRCFGGEVSWDKDHFVGATFDESDESIAYQIVDRPSMDKQYLSRYYVQPQWVFDSVNARTLLPINKYLMGAVLPPHLSPFVDKIKDQVYMPPEERALKDPNFKPLDDEPSGSDIEEASDEDAEEKEEDSSEEDDEKALTRQYQQEVAEDSTSEDEDVKDDLDPEKKKLAKEKKKAMAVSTGVTHKENPYQKEIEDKQAFRLREKLVRKKHRNLYKSMKAGQEQRKKEIWLLRKKRRLHDEKVKEEKKAEKRKQKMQALEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPK7</accession>
    <name>A0A194QPK7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC1 domain family member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPK7"/>
    <dbReference type="STRING" id="76193.A0A194QPK7"/>
    <dbReference type="InParanoid" id="A0A194QPK7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="188"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="539" mass="61270" checksum="FD0F7D23329E7C8A" modified="2016-10-05" version="1">MFLLMHRDQLTFSALGFILLIGVFPWKSSTSKTQESTTTGVTWRLFGSKSTNNLSVKTGSESQKSLTPVSSAANTPHHHKRQGSSASEKQFEDLVASSIALIQHDRPSNLPAKCSEEAMRHRLEHARMVQAARRRVEREAAARLARVHHALRHEERLATHAHEWSRTILPDWHNMKNAKRTLELWWSGLPPSIRGKVWQLAIENKLKISPEMYKDFVAKAKQKLLEAQQRRKKLKLKNREACGCQDKEKNDSDRESKEDKEVTEKSTTEDDEKPRLGMPRNFSEQNLKSLNVESCPKKCCSKSNPNLLEYNDECSMELIQLDIARTFPHLCIFQPGGPYFDVLHELLAAYVCYRPDIGYIQGMSFIAAVLILNMEAPQAFVCFANLLDGPVLRAAFTRDGAAMQRLWKAYGRLLRYNLPALAELVAPELYLVEWLYTAFAKAMPLDAACRVWDVFLRDGDTFLFNAALGILHLYQDELKDMDFIAAAQFLTKLPEDLDPEALFKSISSITMTLDGMSFEELASCCELETTLDDDVTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPS0</accession>
    <name>A0A194QPS0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinoid-inducible serine carboxypeptidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Serine carboxypeptidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPS0"/>
    <dbReference type="FunCoup" id="A0A194QPS0">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPS0"/>
    <dbReference type="InParanoid" id="A0A194QPS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264540" description="Retinoid-inducible serine carboxypeptidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="439" mass="49759" checksum="7B8ED60A97C36110" modified="2016-10-05" version="1">MLFYIFLITAFVSHCSEAQFGPYKQASDYVTVREGAHMFYWLYYTTAPVKHYTERPIIIWLQGGPGGSSTGIGNFEILGPQDLSLKDRNYTWVKNFNVMFVDNPVGTGFSYVDDVKYLTKTNLEIATDFVELMKGFYESHREFEGVPVYIYGQSYGGKMAIDIGIEMHKAEKEGTLKSNLRGIAMGNAWISPVDATLTWGPLLLAAGLVDQDGYESIQAAARKAERLFNEGSYVESTNQWAQTQRAVFAATTSVDFYDILAPRNVTLPDTRKSAYEVAREMMIRDSPLRSRSETDEWDTHILMNTRVKQALRIPEKVRWQASSNAVFNAQNGDFMKPVTDGIEKLLNETDIILTKYNGNADLICSTPGQILWVDRLQWAGAEQYKNSPRRPIWENDRLEGYYKAHGNFRFFWINTGSHSAPRSSPEALSAVLRDMTTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQM6</accession>
    <name>A0A194QQM6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Copia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_12644</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQM6"/>
    <dbReference type="STRING" id="76193.A0A194QQM6"/>
    <dbReference type="InParanoid" id="A0A194QQM6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="250"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="493"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1111" mass="127566" checksum="4A23624E8A90F45E" modified="2016-10-05" version="1">MNQNQQHRKSTERNRTVQAVEINQPNNGVSDEFSGFAFMTGEHNNQEQDTVNKITFLLDSGASDHIINREDLFISQSSLPTPIKISVAKHGEYISATKKGTIQVTTNLGVRGTLDNVLFCPEVPHNLLSVSRMQQAGYTVVFGQHGADIRKNGKTIMQGRPVNNLFIIEFLTSINSPAFHLCGFDKNNYKLWHQRLGHMSKNKFLEIKINNLVEDIEQISSVAPDDQLCEACINGKQSRLPFNQAKDKSYIKRPLYNIHSDVCGPITPTTVDNKNYFVLFVDEYTHYCVTYLLTYKSDVFSAFKDFVAKSEAKFNTKVVNLYSDNGREYLSTEMKNYCVEKGITYHLTVPRTPQQNGVSERMVRTITEKARSLINGAQLDKVFWGYAVLTAVYLINLTPTKSLKSPQTPYELWHNKKPQIKYLKVFGSTVYVHNKTCKSKFEEKSWKGIMLGYEPNGYKVWDPASNKCVVVRDVVVDETNFLISRPLWKPEENVENSHDKTDVTFSKSVSNKSRNSDGSKSDVLKSDDHICPSKIRKTNHDTISIKDKSDSVSVSDPNQNTVNSELRRSDRLKDRPPISYRHDDDDDYLMCAQSVVCEVPSSFVEIRTRNDRSQWEGAINDELKSHAINKTWTLVPRPQGKNIVDCKWIFTVKNDEFGKPSRYKARLVARGFSQQYLTDYDETFAPVARIATFRFLMSFAIQHNLLVHHMDVKTAFLNGQLQEEIYMKIPEGVPCNNSNFVCKLNKALYGLKQAARCWFETFEQSLKREGFQNSSVDRCLYVLNNGDVNKNIYVVLYVDDLVISCSENERMQNFKRYLMSKFKMTDLNDIKLFLGIKITRSEDEISFDQSAYINRVLDKFNMQDCKPVNTPLESKLNYEALNSDVTYNAPCRNVIGCLMYIMICTRPDLSTCVNILSRYTKFNNKELWQCLKRVLRYLKGTINLKLCYKRSEYNHILSGYVDSDWGGQDTRDRKSTTGYLFKAFDICTITWSTRKQMSVAASSTEAEYMALYEAVREALWLKSLAVSMHICIDKPIVIFEDNNGCISIANNPTNHKRTKHIDIKYHFSREQIEKNVITLNYIPTGRQLADALTKPLPAVAFHEMRRKMGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSE2</accession>
    <name>A0A194QSE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Platelet-activating factor acetylhydrolase IB subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSE2"/>
    <dbReference type="FunCoup" id="A0A194QSE2">
        <property type="interactions" value="1414"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSE2"/>
    <dbReference type="KEGG" id="pmac:106719939"/>
    <dbReference type="InParanoid" id="A0A194QSE2"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="225" mass="25872" checksum="35433BF052D3EAEE" modified="2016-10-05" version="1">MNPCSDATPQHDNEGDGRWNSIHNRFLSDAKGKEADVVFIGDSILQALEHTEVWNQWFAPLHCLNFSIHRDQTQNVLWRIKNGELDHVDPKVVVLHVGTNNVDHSAEQICEGILEIIRTIREKHPNAYIVLPSLLPRGQYPNCLREKNFKINQLLREKVLNMNKVEMVFIDKGFVQSDGSISHHDMHDYLIPTNTACRKAFEPIYDLLQQILSESETEKDLTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSK9</accession>
    <name>A0A194QSK9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QSK9">
        <property type="interactions" value="1495"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSK9"/>
    <dbReference type="InParanoid" id="A0A194QSK9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000099">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="638"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1666"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1673"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1697" mass="188361" checksum="F02CBB87FCE08D65" modified="2016-10-05" version="1">MASIVGGIPLPSIIDSPLEIVGGTPAQTTCASPHLGHGTRRALRPPRTDLDKTESKQRLKMKKEIGVKVVGCSNGHASTPNGRADDEGGGGVPAPSPPRASYAAAAARRPQSQASPQTSPQTSPQTTPQTSPQTNMPQTAPPHFTPNADGQKSKVNMEKPQQAKPNGIMAKVNGENPTLKSDDSKKDETSTKEPILNGTEISNENIVNGDPKLYSDCDISSSDNGKIVTNGVVSDSDDNKCNKSEDVKKMICVKSSPATEAEAKQTNDKKKINKKANSTEKSNETDKKKTSTNQATENNKKEEVSNTKNESELEKTNGVVKLVNGDKDRESSPSEDGDEKKKDGEVVFIQDLGFTVKIVSPGAEPLDIQVSSMELVQEIHQVLMDREDTCHRTCFSLQLDGVTLDNFAELKNIEGLKEGSVIKVVEEPYTMREARIHVRHVRDLLKSIDYVDAYVGQECSSLAFLNIITQGDILEKKKSRPESVDCTPPDYIMPGSTERPLLPLHPGLTKENKAPQCLKVLTTSGWNPPPGPRKMCGDLLYLHVVTLEDRHFHITACPRGFYLNQSTDEVFNPRPSSPSLLCHSLIELLSIVSPAFKRNFALVQKKRMQKHPFERVATPYQLYQWASPMLKHTVDAIRAEDTFSSKLGYEEHIPGQTRDWNEELQTTRELPRATLPERLLRERAIFKVHSDFVAAATRGAMAVVDGNVMAINPGEEPKMQMFIWNNIFFSLGFDVRDHYKDLGGDAAAFVAPRNDLQGVRVYSAVDTPGLHTLGTVVVDYRGYRVTAQSIIPGILEKEQEQSVVYGSIDFGTTVLSHPKYMELLSKAGQQLKIMPHSVISANGETVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLQLEDDELREDIKSMGFPIIHKHKLCCLRQELVDSFVESRYFMFIRYAAFHLQQLSAKRLRENSEQKSLEAKKEEDKKEAKETETKDKKRETKSQEKEVKDKKQKKESKKKEEKAEIKKEDKTEVKKEDKVDAKKVENVEAKNEDSTKEKEPEKAKEVKEDKEDKEKEEQILLNENYSDIDTDVAKKIVESITDSICNGEKQETDSSDRSRAVVASAARAVASLKESEFDVRFNPDVYSAGIKHSAPPEQLARQRHLVKEAAAFLLTTQIPAFALHARGINVRYLGRVALALRPHASLQYLHAIAIAELLLRAAKHIYTAYLQNCEAMCTGAAAAHFLNCLLGACPAPAAAPSECPMPARARPRGRRARRHPRAASPQQPAPTSPTSHWQNLTPKSLFSQIKHELKAYWGYELNAENMDVVIEKHGLQKISLLRSFALKVGLQILLREYDFDNKNKAPFTPADIMNIFPVVKHINPRASDAYNFYTTGQSKIQSGAVSEGHELIAEALNLLNNVYGAMHGEIAQCLRMVARLCYVTGDHRDAMAYQQKAALMSERVNGIDHPYTITEYSHLALYCFANGQVSTALKLLYRARYLALLVCGENHPEMALLDSNIALILHAVGEYELSLRFAERALAVTRTSHGARSLKAAVARHLLARTLSCLGDFRAALHHEKETYSIYKQLLGEKHEKTRESSECLRHLTQQAVVLQKRLAEASARPAAHGQHAQHAAPLHIQPPAMASVIDMLNLINGILFVQISPQDIEQFKAEIEKRQLKDLAIPGLGELTKVAEKEESPAPMAAPTTSSDATDAKDMVNASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT64</accession>
    <name>A0A194QT64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Death domain-associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT64"/>
    <dbReference type="InParanoid" id="A0A194QT64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13150">
        <property type="entry name" value="DAXX_histone_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.810">
        <property type="entry name" value="Daxx helical bundle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038298">
        <property type="entry name" value="Daxx_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="12">
        <location>
            <begin position="643"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="729"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="929"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1338"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1339"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1450" mass="163874" checksum="6769C280017F1B40" modified="2016-10-05" version="1">MEVEDVIELGSSDDEAEPPAAKKIKPLPNAMVHIPNKIRDVTINPVSCNKNKLSRKLVTRTPNQTPIVTMSRTNINARQSKPNGRCLHRLTPQPPSQNLKTDKALQIQNKLNSYPLKVLPRKPLKVGHWNSGVQRPRVQGISPKLISSLPPSITVTKTHGGSSTSHSGVLKNKIRVNKEFSNNTFGHSINKIYPASCIGEILTVELDDDENTSSVDNSSQAQWYMRPEEQLEKNKLEEQNNSEPKVKEMIEITIEDSPVKPCLLERAKNINDTLSITIDDSPVKVVKKSANQADLGSDTEPGKPNSPHSKKKLDYPEAEKSNEVSMEIDGGNVTESEPKEVKDSDEIALATAVKETKDKDGGINVDKPVTSTADLDEVNDTTQKDVSPKNDNLAENSNDVEKNDSNNKDIMDVSNESSGEFHSIFQQFMDLCLEIDKSEDMRTIVEKRIKTYSRQVPKEFVESEQFLDMVSTKITLIKSEPSKIYLHIKDIVDELKLHRKRKKATPVVNENQVDEKPEDLDDYNNKYDRKRRGQIRKLEKTLKKLQRAINKLDEQEVDFDDEEDSVYLLNDRYKERFVRTYAKLCQLTDTKMLTEPRIVIECRPGQPPGPAKKLEKWINKKVPIGSTLPFPDFHDVIKCVREANTEDKLGWNEADIIDEARDLFTRCGKKLQRRRQENEWRLAVSRISQDLDPAEKDESLKKKLDENMEKACKKETELFNKYAQKQNQLHLEPTEIDEKDADNSPVESDDEVDDDSDSLEDSQKRRDRLQRLIDEKESKKNNLNNKEHQGLENENGPETESLSIEGKENETETINVKDQDIIYVEKSKQIEEKMETETDYDRRNLVEKINITTNFVSALDVINEDDFQKEQILSEDVEGIMSDETVQDIDVSPKTTVVDLDSNLNEEENIHLLCDDFYGDELNLLEKLNSGNETSSPDSSDLDDSPIAISDSFDSNSESEHYETYDVISIGNSSCSETEITTSEKNKITSIENNDTVISDNGVACDLSSKVQTNRNIEPDKRRTISINDITPSEDESENILLAYSEDEGCSKCVNLQDNSLTVGETFVGVVNNTESIVNDIESNKYEEVISKDDEIISTTETETNTIIDSVGLENSNNKDVYLKNCDDVIDGDDTITNISDNCAQEKSAITVLDKNLGDVITEEKQSNKNSNDSLLFENANDCNNVLTTVENTGDMIRLETSEEPITLEVSEESRVPGTKAETTTPKATSKSKSLEESRELILLDDSQVIKTKESSGHVRIIENEQESKIPKVNCDPITLEVNRESKILDKSWETVLLEDNSETKTFEKSGERITPEASRESMTLDKSWETLLLEDNTEPEKHQQNKEPKPFEASQESKREARGKTMDQTVSGDEITLAMNEEHTTFDEDVEPITVEVGEEPKSIDDNTDTSPCALEEPLPSTSGVNNNINMYFYNTKVRLKGQNATRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTE2</accession>
    <name>A0A194QTE2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTE2"/>
    <dbReference type="FunCoup" id="A0A194QTE2">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTE2"/>
    <dbReference type="KEGG" id="pmac:106717864"/>
    <dbReference type="InParanoid" id="A0A194QTE2"/>
    <dbReference type="OMA" id="LNTYFCA"/>
    <dbReference type="OrthoDB" id="6234541at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22816">
        <property type="entry name" value="TMEM203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15571" checksum="B2CD8317531D5B1B" modified="2016-10-05" version="1">MFFTLKEIVQWIGLTVFEIWINLITLTIFSVLLALKIDGVVNSAWWTIFAPLFVSDAMNAYFCCIVCIRMNYESSYRASLYRASWSGIFLGLTFVFKFLLCRKLQGDSAIEYSEVFAPLFILLQLIAVRACQLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTE7</accession>
    <name>A0A194QTE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP-ribosylation factor-binding protein GGA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTE7"/>
    <dbReference type="FunCoup" id="A0A194QTE7">
        <property type="interactions" value="1401"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTE7"/>
    <dbReference type="InParanoid" id="A0A194QTE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03567">
        <property type="entry name" value="VHS_GGA_metazoan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000023">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF1">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="9">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="11">
        <location>
            <begin position="170"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="11">
        <location>
            <begin position="572"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="10">
        <location>
            <begin position="913"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114765" checksum="F63CA2EFD6C1F797" modified="2016-10-05" version="1">MNITLTSLEALILKATHESLPHPDAAALEAFCTIMKDSVDGPQLAAQALAARIQSQNAREALLALSMLDRCMRRCDITFQNEIGKFRFLNEMIKLVSPKYLANRTSHEVQTRVLQLLYAWSTQYPKETKFKVAYDMLRNQGVVKETPPPLPPEDAPFSARPRAKNAIFEDEEKSRLLQKLLQSKRPEDLQHANKLIKTMVREEERRNEANSLRAQEVGAALDCAGLLRDMLARAVDASHDEKQLIHELHASCARLRPALQRLAALDTQADNLDDILHAHDVLVEVSEKYQEFVLQKTPQLKGAKDMQATNNDTLLDFAGAIINKNVDVAKTTATVNKANVIDELGDIFSDGSSSNIAAPLKPVSLIQNEDIDLLGDKTNKAEGWNELDNLGEQLLKQSLPENAKRIDNFSGKQVKKIPMNALEVSSPKHEHQTANDSSLFDLDFFIKKEDEKIDSPETSETAKQLNDDVMVDITPNTVDNSSNIKDSPLDSILDLGLPLVNNVTHVDIESTVTKTQVNTTPEPKDTTKNNKYSDVKPLTDINVTLQSIRPSKVPPLTVFEEEGGLTVVLHFCRDKPRPDVNVIVISTTKDLQHANKLIKTMVREEERRNEANSLRAQEVGAALDCAGLLRDMLARAADASHDEKQLIHELHASCARLRPALQRLAALDTQADNLDDILHAHDVLVEVSEKYQEFVSQKTPQLKGAKDMQVTNNDTLLDFAGAIINKNVDVAKTTATVNKANVIDELGDIFSDGKDIDLLGDKTNKAEGWNELDNLGEQLLKQSLPENAKRIDNFSGKQVKKIPMNALEVSSPKHEQQTTNDSSLFDLDFFIKKEDEKIDSPETSEAAKQLNDDVMVDITPNTVDNSSNIKDSPLDSILDLGLPLVNNVTHVDIESTVTKTEVNTTPEPKDTIKSNKYSDVKPLTDINVTLQSIRPSKVPPLTVFEEEGGLTVVLHFCRDKPRPDGCKVRLLPASGSSLPAYNPFLPPPALTQLMLVGRPALLSRTHLKFVLTYTCDDEMYSEMGEADNLPLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTS9</accession>
    <name>A0A194QTS9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTS9"/>
    <dbReference type="STRING" id="76193.A0A194QTS9"/>
    <dbReference type="InParanoid" id="A0A194QTS9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000065">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056707">
        <property type="entry name" value="DUF7805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF3">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25090">
        <property type="entry name" value="DUF7805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="243"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119018" checksum="6E354A36C435C129" modified="2016-10-05" version="1">MNVLDVDMNRCTHLDLNDELVNDEISESVTEISVNTEKNVKTTNKGTTVSSCRASELLCDTGQCISLDKYCNGEDDCGDKSDEPKACTPCNRTYMGDVGRTYELEVRRPREDHLPFICNLNFTATGGNYGDIIQLTFDTFTVGKFVSFTSDGCPDGHMTIVERSPSPPTGQWCGSAWGYTVYFSESDSINMTLRLDRLSQQGVGYNFDFKLAYKFLRRSEARLRYGNATVGAWRGERVPGTYCDRILTDCDLRACRIQSPNFPGVYPRNATCTYRIEHTKIPADKHVLLAVRQTNSHKIHIKDQIVKYDRSQRVLKIWDQCNVVQDYLTVWDGATRESPVLVRLCGGDAVPDIVSRGPHMLLEFHTSPYDNPFHPVPLSYLPGFELEVQVLYVDKDSHSYVRTDGRCRFILRSSDKTSGILRNPRHSLPPNTSCVYFFQLDMSDKKLLLGSFCREESPRLCDHALLSNATRATRPCAPSESYITTGPALTILQELRQGSALYPVSFFLRYEFVDVSEQGQPLTDSRSACDRVFKSAQTYSGRFQAPRAIFYYGRGGAQNLTCILRFEAKYGERVQLTFTNTYFGNKYCITYKDSRSSRWVCDKPIKRTIGGEGYAQIIITEYPWEGVPIQRDCLCTNRSEPLNIHTLTAPVVEVNFTVTMMNITEDYDDFAFDGEFKFVPTGSSDESICSSGWGDRRLRGSSGEIRLYDKRQMPIPPEIIGDRNVISESVRAEVACVHRPWLIEPGGDEVTPLHGRYLYMKLPGFEMSTTSTFCPTPNRIYIYEAHDTSKPKEICPDENESMELFSPGWSAAQTNLESSLKPHARSYVIDFLQHEPADYSIKWIEVMKKSAMENEADSVFFQTSISLECRYKCPELNACIPFTLWCDGNAHCPSGYDEEDSNCSFRISLPPPYVAAAAGVGLLLCAITVALCACRRRRRKEKQFKARLDGALPSEERPYDRVKSNGVAETIPQYATVQKYATLDKYSLSQKYSAGLNDARYYDEVSQRDKLADNRYASLGRGNRCARTDSIRGNGSRRPNPDIGYPDLKDGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU08</accession>
    <name>A0A194QU08_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pupal cuticle protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU08"/>
    <dbReference type="FunCoup" id="A0A194QU08">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU08"/>
    <dbReference type="KEGG" id="pmac:106717504"/>
    <dbReference type="InParanoid" id="A0A194QU08"/>
    <dbReference type="OMA" id="HRYRCTH"/>
    <dbReference type="OrthoDB" id="6365759at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264630" evidence="5">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="199" mass="19724" checksum="C1763A4E3B94C8C9" modified="2016-10-05" version="1">MSPALFVMLSALVVASSCGRLEPQYLPPRPGGGGGGGVFGGGAGSGGGSGIGIFGGSGGGSGGSGSNPSYGGNGGPNIPILRYENENNGDGTYRFSYETGNGIQAQESGAPRAQGPEGPAVTAEGGFSYRAPDGQQISLSYTADENGFHPVGSHLPTPPPIPEEILRSIEFNRRNPSSEGAYNPGAGSGGNGGSNGYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU44</accession>
    <name>A0A194QU44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcriptional repressor CTCFL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU44"/>
    <dbReference type="FunCoup" id="A0A194QU44">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106717265"/>
    <dbReference type="InParanoid" id="A0A194QU44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000373">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002321">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002596">
        <property type="entry name" value="Transcriptional repressor CTCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000049">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003164">
        <property type="entry name" value="Zinc finger and BTB domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="675" mass="78162" checksum="2C9744C097FDFA92" modified="2016-10-05" version="1">MSVPEPPEGKTLLQSFINNFNQQNEAGVAAMPGTSNAVEEVADSGIAYFVDEEGRYYYQPADDDQNIVSLPMVTDEIAEAIQEDEDEDEEEEEEPAILSDFKEYQTVTLMPSENSSGGVSYVLVVQEDPKQVVNINIQGEKNNEDVYNFEEEDEEGGQEGTDDDNEKSNVTTRGKHSKYVRPRFTCNFCSYTSHRRYLLLRHMKSHSEDRPHKCEVCERGFKTVASLQNHVNMHNGVKPHVCKYCNSPFTTSGELVRHIRYRHTHEKPHKCTECDYASVELSKLRRHVRCHTGERPYQCPHCTYASPDTFKLKRHLRTHTGEKPYKCDHCNLCFTQSNSLKAHKLIHNVSEKPVYACELCPTKCGRKTDLRIHIQKLHTSDKPLKCKICAKTFPDRYSCKVHYKTHEGEKCFKCEICMYASTTIRRLKSHMLKHTDEKPFVCDQCDQRFRQKQLLRRHQNLYHNPDYVPKPPKEKTHTCHECHRTFAHKGNLIRHLAVHDPESGHHERVLALKLGRQKKAKRVDGQLKEVREEDSDSEDNDQNSGIKMNVSGNELQSEYVTVSDGDNQQYVVLEVIHLEDGTEQQVTVMAPEYIEEDEQVEEEEEEEEEEEEDDDDSEDTKNNQILLLHEQEKQKSMERTLKLENDVDTCFGFDEDVEDGDDEVPYEDKVLINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUA4</accession>
    <name>A0A194QUA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUA4"/>
    <dbReference type="FunCoup" id="A0A194QUA4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUA4"/>
    <dbReference type="InParanoid" id="A0A194QUA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000105">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="254"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="441"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="501"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="559"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="677"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="737"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="816"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="876"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="938"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="968"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123282" checksum="8709062187BE1BF0" modified="2016-10-05" version="1">MHKTSEVELHWQRRCGTYRVMCIAKVRYISERHCGHPAVPPNARVTIPSDTAITPGTVATYECDDGYELFGAHQRECTLRGDWTAEPPFCGTNVAFRKPANQSTTVRGGAAANGNDGEKTTEHDGKRCTETQREASPWWQVDLLRHYAVKVVRVTTRGCCGHQPLQDLEIRVGNSSTDLQRNPLCAWFPGTIDEGVTKTFTCARPLIGQHVFLQLVGVEGSLSLCEVEVFTTEEFSNDRCAPAGASADIELAAFSRNCYEFNVAKGGSFDEARKQCQSHGGDLIHGFQGATSSYLIQELERRKVQLKTQLVWIGAQKEPGLTSRTWRWVDGELVSKPTWGKDQPNNYNGEQNCVVLDGGRAWLWNDVGCNLDYLHWICQYLPPSCGSPDKLLNTTIEGNSYLVGASIAYRCPEGHMLLGDKTRECKEDGFWSGTAPSCKYVDCGGLTPIQDGEVSLIDGRTTHGARAMYTCKENHTLVGEPSRECSDEGVWSGQAPKCLFDWCPEPPPVAGATVAVSGHKAGSLATYTCQNGFILFGTNSVTCKLGGTWAGSPPSCKYVDCGTPAQLYKGSFRLLNGTTTYGSIAQFNCEADYWLSGNEFLTCNRDGKWSHDIPTCDLITCADPEVPAGGYMEAYDYNVHSTIDFHCEHGHKLVGESSLICQQDGEWSGDSPKCEYVDCGKLPPMPYGSAELLNGTTHLGSIIQYSCTTNYRLVGPVRRICTEDHQWSDSSPRCEEIRCPEPIVAENSIVSVTGNDRMHGRTLIRTAGSTNAGNTYRIGALVKYRCERGYKVIGESLSTCEDNGQWSGVTPRCQYVDCGNPGRLQNGIVTLATNFTYYGAAALYECDEHWQLDGVSRRLCQDNGTWSSEPPICKEIICTDPSIQIKGSTGLVVVTSSLSIGSEAHYRCERGYSLRGNQTRMCMPRGVWNGSPPVCIPIDCKSPGTIENGRIIISNGSTLFGSSIEYHCMPQYQRVGPFLRKCLDDGKWSGDEPSCELATNEAADSGALPLSVGVGCGIVLFLLMLLALIYLRLRKAMPVKNTENIEGAERKEDQNAAVMSYATLHDTNGRHIYDHVTDNVYDSPYSERVADNIAYGRRSDTDSAYEPEPTGPNAVVTINGVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWB1</accession>
    <name>A0A194QWB1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein Musashi-like Rbp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWB1"/>
    <dbReference type="STRING" id="76193.A0A194QWB1"/>
    <dbReference type="InParanoid" id="A0A194QWB1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="132" mass="13995" checksum="AF21BC663A8C0E84" modified="2016-10-05" version="1">MRARLATLCQYQAERFPDKLISPLSPTLSIAVCVYLTYVECKKAQPKEVMLPANLAKTRAAGRGAYDFMWSLGALPDGFPAAYAAYAAGRSYSGYPSFGLPYPAGVVGVIPPESRLSVGAEFVNPGALGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWL3</accession>
    <name>A0A194QWL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWL3"/>
    <dbReference type="InParanoid" id="A0A194QWL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="47" mass="5418" checksum="2123768212A720FB" modified="2016-10-05" version="1">MEEHMRNEAGNVSKMWRGGAWQAVVLSAHTMEHKAPTDRDRQQVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QX16</accession>
    <name>A0A194QX16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QX16"/>
    <dbReference type="FunCoup" id="A0A194QX16">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QX16"/>
    <dbReference type="InParanoid" id="A0A194QX16"/>
    <dbReference type="OrthoDB" id="7323052at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264705" evidence="3">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="39734" checksum="9EBD7D06DEB57073" modified="2016-10-05" version="1">MPSAALVALALLATATAAHAQLRPEDAPPPLNDTRCGSECVRCGADGCVRCARLLVWPGGACVRVCPPGTREAWAHDDHLMGRVCYPANTYNEVLVGGACGAVLCVALVAAGAAYARCRGRCQARAQPQPLPPLAQHDDDARLREFHKQLDCLRPHAFTLLAILNHTRHQVRELYQLGNNDAAMAYSCVLSDLAKLLILLNKQQVPVVPDEWPRLASWAERILKRYSRMNVSQQQQNQLVNFLPTPPSQESDSETTQQSFSTFKPPSYSPTSFDSHTIDKELNQNQWNDVRPPSYSQIEREKNNYSQIERQKETITLSDPWERRPIVRRESVWLEDELFEMTRRPQDELTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXH6</accession>
    <name>A0A194QXH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXH6"/>
    <dbReference type="InParanoid" id="A0A194QXH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="135" mass="15176" checksum="4C8B501EE22C5D14" modified="2016-10-05" version="1">MDTTVRILRFLSLVSIAVLITSIAAINNYDLQSSETDQPPRRFFGEIWNSIKNAYNKTEDWVIETVKNIILIVMVSAFPSDEIRSKRDVMDSIKNAWTEMGQTLNDAGDAVVHAVKPTEKSTIDKMVDDVKSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXP9</accession>
    <name>A0A194QXP9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXP9"/>
    <dbReference type="FunCoup" id="A0A194QXP9">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXP9"/>
    <dbReference type="InParanoid" id="A0A194QXP9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF5">
        <property type="entry name" value="FI14214P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="16179" checksum="249F1A8A993891F0" modified="2016-10-05" version="1">MVQEDEGAGAGLIAPRRLPNPCLESPQRMDLHRELLFNQRIRFVSVAYSGLHFARLSSQVQFAADDPVKLHTLLFFINFSLNVLVFCFEILKLERAIAERARRLEQAEQNAEEIDPATNPTLQEIRARLRHAAPPAPSPAASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXX3</accession>
    <name>A0A194QXX3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein LAP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXX3"/>
    <dbReference type="STRING" id="76193.A0A194QXX3"/>
    <dbReference type="KEGG" id="pmac:106717810"/>
    <dbReference type="InParanoid" id="A0A194QXX3"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="911" mass="103216" checksum="4F7BDC3A95844A19" modified="2016-10-05" version="1">MPFNFLCCVRPGVEDVVELDYSHQSLTDVPNDVFVYERTLETLLCQSNRITELPRQLFMCHGLKYLDLSDNELQVIPTAISSLVNLQHLNISRNTLASIPDNMKALKYLMFLDLSVNPLEKLPDAITNLIALKELYLNDTYLEYLPGNFGRLANLNILELRDNYLMILPKSLSRSTELLRLDIGQNEFQQFPEVIGRFIKLRELWIDSNSFTTIPSIIKPLENLIHLEASNNMIEELAPEIGNCVQLLDLSLSINSLTQLPDTIGQLSNLTSLKLDNNRLYCLPDSIGQLKNLEELMLMCNYLDKIPSSIGLLRKLQYLNVDDNMLKAIPPEIGSCTKLSVLSLRANKLSKIPPEIGHLSSLRVLNLVRNSLSCLPQSLLNCDNLVALWLSENQSKPLVPMHSEVDPHTYEQVLTCFLFPQVPLTPIELKNDHEKPENTETQSTVRHISFVDMKATAKAPEKPGQLRRAPTPYPKELRAMAKHARNIHKDGTQDITPPMQNAVHIKAAKITPTLQQRFASDNKKESNNISTMENGGNIKETFKTASIYDNLPPENAYDRPLDLTYEQDKTYKSVDHALYVENNSTTNIEYEAENGEPYTQRHYSNKHDKYQQQEMEKPNNCKQSNSYADHLELKSYHQANDLSYRSNIDETQNHFQRLSLSSQDRHSNEETILAPHYNETPYNARVENVPTFDPSYHRQEHVMCHNIPASNYHDNIYEHDAYSCSKEKIYGQRNYNAYGYHSHGGHDLPPGPRVHTVSQVVSSTTMPNLSNYNNVYVQPTAENHHFSGPLHQSTTPNANVYGMASSPTYIPSQSPELYSPTGHTNATNPYRMTNTPLVTDDGSFSHVQSPTSQNAYELYDAGPATHSPNVVSHRHSPSGVSESMYMRGQPPPYHIAAPYTKHAQYFNGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0U4</accession>
    <name>A0A194R0U4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_10050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0U4"/>
    <dbReference type="FunCoup" id="A0A194R0U4">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0U4"/>
    <dbReference type="InParanoid" id="A0A194R0U4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="220"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="44712" checksum="AAFD4EEB78B793E7" modified="2016-10-05" version="1">MQLLELLDLCMGLNACERKSYLFLRKELPVRLANIMKEIALLPENLLRMPSVGMVNQWYERSFEEIIQFEKMEPEPSILSQFCERLVHIRNRHADVVQTMAQGVLELKESHEVDPGTENSIQYFLDRFYMSRISIRMLINQHTLLFGEQMGARQASVNGMGCGGRHIGSIDPACDVAAVVRDAYENARFLCDRYYLASPELELLQNGVASDSPMPIIYVPSHLYHMLFELFKNAMRAVMECHENAPPPIQVNLVSGKEDISVKMSDRGGGIPRSVSDLLFKYMYSTAPQPSKSDSHTVPLAGYGYGLPISRLYARYFHGDLVLMSCEGYGTDAVIYLKALSNEANELLPVFNRTSSKFYKSMPTLADWSGSLNTASNSQCARAKNREKLSPSISHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R165</accession>
    <name>A0A194R165_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R165"/>
    <dbReference type="STRING" id="76193.A0A194R165"/>
    <dbReference type="KEGG" id="pmac:106714806"/>
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    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="453" mass="49085" checksum="E6ADAE617CE2FBA7" modified="2016-10-05" version="1">MADAKQGKTTSEDLHNGSSQSRVILAKPRLGGFGSSSFASSSNKPCNPFGSVLRPPQLKPTNNPFYKHAETPEDVETEKEKPSQAEPVERLQDKKEEVDPPKFVPLGSGGATTRSSSTVPAPAQPTTATSSAGFVFGQNLSERVVMADSVNNGDATTLDHSSTNGTTELLFTNAAASVKENNQEEAGPSENSGEGLAAAAAEYERSHARPPPPTSNCTTTGEEDEINVLQITCRLFAWEAGSWRERGRGVLRLNDAPQGGGSGGGSRLVVRVAGSLRVVLNTKLWPDMVVERAGAKSLRITAVDAQLQIKLYLIMGAPSDIVHLYRALTARISGSKRTISCNQNATSQRAAERLEAATDDADYPDKQDYNEDDSCFEEDKQNFPEPQEDEGGEPIISNNRLETNPENKTDEEKLNVHKKIDDENESNALKRKEPVEDETTPKRQCPEIVIQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R191</accession>
    <name>A0A194R191_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R191"/>
    <dbReference type="FunCoup" id="A0A194R191">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R191"/>
    <dbReference type="InParanoid" id="A0A194R191"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20539">
        <property type="entry name" value="CYCLIN_CCNT_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000004">
        <property type="entry name" value="Cyclin T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="878" mass="98897" checksum="7101B279CB01D379" modified="2016-10-05" version="1">MAGGQEKWYFTKEQLQNSPSRRCGLDADKELAYRQQAANLIQDMGQRLQVYPFQCGYFSAMFLSSHVEEQPRKLEYVIKVAHVCLHRGEGVNALTTEQYQEQAQDLVFNENVLLQTLGFDVAIDHPHTHVVRTCHLVKAPKDLAQTSYFMASNSLHLTTMCLQYRPTVVACFCIHLASKWSNWSIPQSHEGRHWFSYVDRSVTSELLERLTAEFLHIFDKCPSRLKRKMMTMSNNSGSSPHSNAAHQSSSAGVANSPFDKKHPPPNSDEFDKSFDKEYERERRRQPGAGGYVPATAPPAANPPQPQKIDYNLYREKREREERERRQAALQQARPSSSQQPRPPGGSQPPPHHQRPSSSQHHHKPHHAWPHHKPPHHKPPHEKPPHEKPSHEKASHEKPSHEKPPHEHRHHRPQVHPATPAAPVSHPPQPEQIPQRTRPPSLFSPENATTPTAAAAAAPRRPQPSQPQNTEHRPPRPESRPIQQPPSIPAPIQQSHTQPVIDQRAPSPHKKRPDPTAAIREMQPPAILSPFSSPPAKEPTPKPRQRAPSNSEPELIPVVKKLDETPGYENVIRDSQRGNTIRSRPPEQRKPEPVRSLNGIETDPTLVSNLLKESLAKPAPITVQTERKSPVEVKREPVIEPPAPVQLPPQPEPPAQPLSQEEADHKHKKEKKKKDKHKHKDRDKSKEERKKHKKDKEREKKLEPSPQPPPAEPLTDGALRITIPRDKLSTSPGLKIKIPKERLAAPPPPPQPSAGLKIKISKEVLETSRKRTGVPEPGPPPKMPRQNGAPHHKVGNWNVPPPYRPPLPYYVVQPPPPLYFGMGMDGYFYGGMYGPPQPRPQMALPQPPRPPHAPHPPQPRAQPPLPAMPPPPVPPPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1B6</accession>
    <name>A0A194R1B6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-Va</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1B6"/>
    <dbReference type="STRING" id="76193.A0A194R1B6"/>
    <dbReference type="InParanoid" id="A0A194R1B6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="12337" checksum="5E96ED737796AABD" modified="2016-10-05" version="1">MTTKELYTKDARVWVEHPVKVWEGATITSDYRSGVLIVKIDQTGEIRQIKIKDENQMPPLRNPSLLIGENDLTSLSYLHEPAVLHNLKVRHMFQQPYFFACFDDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1J6</accession>
    <name>A0A194R1J6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RILP-like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1J6"/>
    <dbReference type="STRING" id="76193.A0A194R1J6"/>
    <dbReference type="InParanoid" id="A0A194R1J6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH2" evidence="3">
        <location>
            <begin position="88"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="256" mass="27884" checksum="672E1D4A88D5DEE9" modified="2016-10-05" version="1">MAILDTLQLTNQVDKLAQVSRDLRRKHKQLQNQMRLVCEERTELTAIVQSQQRDIAALQQSDAQKTQKCTSCGAGFPEGGEEGDQSSRPTFSVRELRAILHERNELKLKLNRLEEQLQALQVEPQPDSTSSDTSSSVSTTVNEEEEAPVQGPLPAEPDDAPWKRNSGIRKFTSSDTSSSVSTTVNEEEEAPVQGPLPAEPDDAPWKRNSGIRKFFRKLFAESDLSVGAFSRPMSARGKAAPPPGPGPAPAPAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R332</accession>
    <name>A0A194R332_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R332">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R332"/>
    <dbReference type="InParanoid" id="A0A194R332"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000894">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1466"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1489"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1697" mass="193814" checksum="188FB967E011030D" modified="2016-10-05" version="1">MSSSPGAHVGEVATILRPYEGRLCGDASSEGSSDAAEDLELPQCKIRRNYSCTKCTFYTQNPRAYLIHTRDVHFVKLKIYDCAFCVYASRHHQKLVRHIKMVHGESGSDRHAEMEPPPPTSIAATATESSEKEEDLLEEVEECDEDMDVEDCGDDLIERLEVDGDAAMIVNGTSDAKIKGNFFSCDKCNYVTHIRARYTKHVKYHSMPMIKCTICDFRTPYKWNLDRHMKNHGGTGSFCCSICNFTADIRQSLTVHEMNHHTPPVGQLTSNRRRNRVGASDLCLAEEAASGSTRVPKEEEGSGDSRSSHSASEMGLQYAERELVSCNSDSNDASETSSKNGSSHTRAGQHQESALEDSKSRKQSRKIPRPIPQLIPLNSSTPNQNKTTSGEPPMKKFKESISSDSPDSSNSNRLDCLPPDVTFTPVINSPPVKETSTRKKHESFFDKLKERLLTETGEEGSLKCKNCGFESKCLSEHSVHEKTCSTQTSRTHSNTLMSSLSSTRCQNCRHRCKSSADLYVHMKTCKKNEEEAKAIATETQDSNEAVCSSTEKEVEPHPMENVVFVWNNINTETTKFDTPLDISINDDSTLPEPPQSFDSENVDENEGMNLSPSQAVGKKVFKCPHCMFWASTASRFHVHIVGHLNKKPFECSQCKYKSNWRWDITKHIKLRSARDPNHTDAKVLMTDETGRRNYSKYNKFLAMPILNENGENEFHYIEQNTNVDASLDVDESYNDANELTNTSTDMQPLDLQTQHGDYKYSLDNRSEDTKRPKKTLWKCKKCNYRDSSKEALLEHVREHSKASSYGLDDAKSQQGASGATKKPDNMTDPADLAYRCGHCNQLSNWKHVIQRHCRLKHDGVIKVVTTVKPKLEGSTLLNESVSDSCTKCPFKSNDKTMLIIHMQQHQPSPQSIFKCYFCPFFVKDEQELVQHLVLHGITDPEDYIAKAMGCKSPLNEQQSTHQSSTKRHKCTECPYETNSKSQFMYHEQFHRLPADTPYKCPECNYSVSKRHLLHQHMRVHGIMSKKSEFEADLEASTSISYKTESKSDPNLDEIPYVWVSAKNEFHKMYKCRYCSYVNTQKCKIPNHEKIHCIANAHNEVLVYKCLDCKFTCDSSGRLADHSKTHGEIYGRIYCPVEPDIPDEDQIAKLRKVIEEEKMNAADEFVKEECATPENKVIKTLHFCQKCPARFFTDSELKVHDKFHDLSFPNKCRSCEFSTLHDIELAAHIFVHSDEYHTKTKMLKFIHNTDPTHPEPRLELVHCAATSEINWVVTLPGKNYDDMDISPKKSHDGKHIPKQYLCKECPAKFFKTSALNYHMSLHGGDGENKCKKCSYAVKNIGNLAKHELLHETDAKSTCDYESGEDMDYKNIPLSGTDLFQRKTEAQKRVLNDKDKLVKPNDHFPPVLQADPQFGYLMHGNPEFIYPTYLKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCELCDYSVKYYANYVQHMRKHQKNDEAVAERRRGSNGFLESEEPTEHKKDESTENIKLAIKTMPKGIPKSDFQQFSISDQQTLRLLQRRCALNNSINDTNKTDATPTKDRKLHPCFLCPYTNQRQDALGNHFRRHDKNDNFNNGNHKCSFCDLAVVQSHFLRDHLKTHFNYQKNLTPECYVANEDVKFTITKLDEEESVADLKLDIQSKVDICNDEKIFVKIKTGELLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3C3</accession>
    <name>A0A194R3C3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Triple functional domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3C3"/>
    <dbReference type="STRING" id="76193.A0A194R3C3"/>
    <dbReference type="InParanoid" id="A0A194R3C3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="760" mass="83001" checksum="0F8F0D42C4E0263B" modified="2016-10-05" version="1">MEAGARALDVLPLLQERVAALTGGLDRRGGPIIWFPANSRRDRVAPDDYRRLLHYLMSIPSDSVRTHGFTILIDMRGSAWAAIKPILKVLQEHFSSSVHQALVVKPDNFWQKQRTTIGSHKYKFETTMISSEALPKVIDSTQLTSDLDGTLHYDHPQWIDLRLALEELLWQAGELLDRLDDLQEDVARADFADDVTGARRAIDAHADIGKRLAKVPVDELEAQGSRVLQRLEAAQAQAAACAEASGEAAFHCGSPGAVRAQLAAVRSAHAHAHKLWQHKKMQLDQCFQLRLFEQDCEKMLEWIVNHRTAFLATYVEIGRSCAAAKRLQEEHARFAAACTGGGRPSVARVATAARRLADKRHYAEAQISALALRLERAYKHLAAGLEERSAVLSLSVVFHHKAEAYAAAVGGWGAQCALALQLASGGPAPGGPARSGRAGRRAVHRPASARAACAAPPPALRAHVPGLYRGEFSAAPHPYSFIRRARSFCTNLTISFKCVIRPTPPIWYGEEGGGGGGAGGAGGGTGGDPAADYSSGANHVLAVIHQILGHHRALEARYHQARLKLHRRLALLLYKEDCRQVLDWLSNHGLQFLQKNTGIGRNLHKARVYQKSHEHFENVAQNTYTNAEKLLSAAEELARSGECEPEEVLGVARELEAHVAAFAARVDRRRRRLDLAVLLYTHEKELMQWLETLRGGGGSVGAGDESPEAARRALEQCAQHRAASLDACAATIAQGETLLQDLRSVTCRDPHSSRDIGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4G9</accession>
    <name>A0A194R4G9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4G9"/>
    <dbReference type="FunCoup" id="A0A194R4G9">
        <property type="interactions" value="1421"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4G9"/>
    <dbReference type="KEGG" id="pmac:106713525"/>
    <dbReference type="InParanoid" id="A0A194R4G9"/>
    <dbReference type="OMA" id="TLNARVW"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000416">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="401" mass="44593" checksum="5745ACAC30BB9681" modified="2016-10-05" version="1">MDRFEYIEARLFEGENYLKREKNVKIYDGEDKTQYVDGEVVLTSHRILWGKPGDIPKGLTCLSLPLYYVFCLEEESSGVFGLGGPKRIILHLGPALPGKRPGPAVVSPYHFVKFSFKDGIDPLFYKALSEAVNAKAWERSTPLTSPSSESAVTSTRPPVAPVNSKIRSGIVGIERSIEEQHRATDESISVAFQDLRKLMEKAKEMVSISKTISTKIREKQGDISEDDTVRFKSYLMSLGIDDPVTRDTFRSDSDYYVGLAQQISDMMVAVLMDCGGIMSLADVWCRVNRARGLELVSPEDLLNACKLLQSIGAPMSLRKFPSGACVLQLNSQRDEEVARSTSQLLEENGNLTPVKLSQLANVSVLLARERLYTTERLGLACRDESIEGLAFYPNLFLTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5S7</accession>
    <name>A0A194R5S7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_14860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the hemolin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5S7"/>
    <dbReference type="STRING" id="76193.A0A194R5S7"/>
    <dbReference type="InParanoid" id="A0A194R5S7"/>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264948" description="Hemolin" evidence="11">
        <location>
            <begin position="21"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="240"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="339"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="516" mass="58545" checksum="4A3F1256826B414A" modified="2016-10-05" version="1">MKWIFYVIVFIYMFYRAVYGIKPKELNSLSVEEIKYGSDKHYYPAGIRKTISCKGANKNQKVEWVDPNGKVIKRVSKNRVFVQEHFVPTTTLRTRVPALVLVLTHATVDDSGLWECRSGDIKRNVSLCIIDPSKFVDTPTEVSVDKGRSITLSCQARGEPEPRLIWYRNGELITEDEESDKYRVMTKYNSQGFEGLLTISSLEAEDSGIYTCEAIQESPHDPSCANTESFNITLQVNYAPVFADANETEIVYQLENESVDVVCSASGYPTPTYTWFRDLGETLFEFPDERVNLQDGSKAVLTLPSNATISSRRYKCRATNQYGEAYKVFVIYKLESPSKPSEITSQEAHHDSLYLYVKWAEEMSFPVKAIEVQYLEKGSLPRRKIESLREGDWRKSKKVEIDLDSAEDVEADSEGFYFTLSDLESDTEYWIRLRAMNEAGESPWSEPALVQTVEQVETEETEEDTKEESKEEAGEGTEESSVPAGLAYSDATFYGVFFAGGIVVFAVACMFLMRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6R2</accession>
    <name>A0A194R6R2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6R2"/>
    <dbReference type="InParanoid" id="A0A194R6R2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="3">
        <location>
            <begin position="389"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="4">
        <location>
            <begin position="591"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="5">
        <location>
            <begin position="1447"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1973" mass="217761" checksum="A87BB2EB06C63BAE" modified="2016-10-05" version="1">MIKIFNAISFFHRGFSVVAPEVAVPGKTTAVLVTLHGNDDTVDPLNVTVRLETQDAQNDIKLLTTASQMIIGYGIISLKIPSSPATHCTLHTTVGCVGNDECTAKSHSVIRLLGPVRDVIVRPARHHYRPGETITFWILALDHDLRLVRGEIAYVALSDPAGTKVAIWDQLSMDEGVRKLSSIIAPGARSGIWRVEAKCGGASSRVDINVGSGSGGASAAAPAAEQHYVELRFADSMRRRYKPGLPFVGRVEAMSTEKRVRVRVKLYDDKTDIYSQDIDMSSGEGGFIVPTVMADAPYVNLQYSSLGPFCFEKPGFRSPSPRADTVSYKTVTQSIIGFMQEVLISNRSEFPEDAKNAELVAVEGKEIETHYVLARERIRRWNSTSKCYLLVENLPTPLQAGGTASASVWSSCGCRQRLLAAVTSGGRAVHWAAVPAPDPTSNDDLCRFNYTFPVTADMAPVSSLLVYYVTEAGEPVSDVVSFHVRLLHKEVAVAVEERRWWYPRAALQLRVLAPPDSLMCLIGARSPPDTRFDPHQPTSEHEEQPGPEFVSAGVSLFVGSGGCGGGGVLYRQRAPPRAPAHLVPPATHDRLWMWRCFNYTNQLSTDGVTIAAPSEAGRWSLWALSLSNRGLRFSAPRTINVFRPIQLDFALPPALKVGETVEVDVKITNNINNCMDVTALLALSAGAAFASTGALYVTERLRLGPRGGTQLVVRVAVNTPGRKNITVEVTGYSADNCSISYTSFNNETLVGSVIRSASVLVLPEGLHRSDTQSAYFCANEHLAVSSLGSWEWQWVAAPRNRAGLVLELRAKGAAHVALSAIREPSEDMYRVVFERSRVWIAKGKHGYDVHLASAEQTGNDDECSGAESWCAWWVWWEGGRLSVGRGAAPAERRLLVWPLTPDMRINYVGFSALWGEKADFRIWNFNEEAGFSQVLELGLPHGVVPGSASGTLLVSGGLHLPLYSLLTDSADQWAAVWRDSQLSAASASLAPLLALEHIPHLVEDNEREKILKKLPEQVQILLSFRKSDNSFSDHPAMSSHLSTIKMLEILTKIQSYYPVDPNLLQSIKKWIQMRQEADGSFSPLAADKEVDYYPLDMKKNNGTETEVNEYYYYDKDGNMTQEEIDSERKVEITAETLAALLEVGIENEFDVTVAKKSQAYLEKNIYNLTSPAALAATVLALVLARFAFDVTVAKKSQAYLEKNIYNLTSPAALAATVLALVLARSPIVPEALTILRNASTTEEGEFGWPAPRKDAADWLLEETSRNIKTTSYEAVTMEQYVAGVRVLLAACARGALAEGEAAARFLYYRASTLQRHPSLAYSATKAAAQYAALAHDRHRALTVSLATAGMELTDTLELRAKTPPRPLQLPGLPTKVFVYATGAGCATVQGTISYSTYTPKAENALLNIQAAIIEEIHPERSSIEDLQGNLPTLIIKTCFKWKGKERSGILRLESSLFSGYELHSVNPVVLDGATFADLHYGSRGESVWFVFANISSTCPVCVTYEARSNFIITSLRPAFAKIYPATRPDLAVETFFHARPGSPLLRGITDDDFITWFDKTEIASLTTTASIDNICECGRICSRDYEFRKQNETSHTLLNFKTNDSHAEIIEIVTVSEFKDTESTSTTTSLTTSPATTIKPVVNDSNSLMTNTISNYLKYNKTSDSSIKSRDSSNTNNQTLDNHLKPLIVGTNVEVNAKRLPKYYPKKEEAKKKVLTRRKGTLKATYGDKHEKFFIKSKDENTLANETHHVDIKILKKSNHSSKIHMKNEINYLNNVTDFKDDKKSTSKVNHILTINNFNKNLTNDTVIPHKETTLTPHTIAAITKSNIQTMHYKTKKPKPVTQIAKPRVNVELNNTDADLKENNKTYVKIPKNKPKPAAVEKTVTKTLKSINKEIHKIPPTPISETSKSLADNIKTDIAPENKEGYEILDKNRLWELLKEGNEAEMTKIEDKLQINNRLNIVSNLTQNDNRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R747</accession>
    <name>A0A194R747_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R747"/>
    <dbReference type="InParanoid" id="A0A194R747"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="153" mass="17350" checksum="AF3320D17495ED6B" modified="2016-10-05" version="1">MAYWKKGFYPKLFTYVDLPSDVVGLVTEKSVGCIAETGADINILQRVFQWQFDDDKTSKKFSFCLFKSTGLIDDSGKFDENQIVNSLYRNSNKKDEIAKVAKECSELGIEFSEEDLLKFSLELVPTVNPHLRLRLGSGRHLSELFAITGFPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7G1</accession>
    <name>A0A194R7G1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7G1"/>
    <dbReference type="STRING" id="76193.A0A194R7G1"/>
    <dbReference type="InParanoid" id="A0A194R7G1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="45582" checksum="0832678C3198508D" modified="2016-10-05" version="1">MLNNFMHESNEYLLKKCLQERMSDIASWRWVLQDLEKRVDETIDAIQHEREALHVVVQRINEEIHASTNFAKPGALSPMIDFVEEAVMQELIFLRQQKKRFETVIPQVENLKVKLEKIKSRIQKEAIQKCEAISVDEACWNTYKPDNYDNKKRKKKKSLSVVRWERRCAKLKDAGINTLRLAVVTRQKIRAARVELSIAAQAYGTRVDSAIRRRLHANIIKLQDLEWQRHEAVRDLKSLDIELETTERSVLNTMDRRKLVEGRLNERRLRPVEEQTADQVTYQLRMEQGKLKRFTNELRNNIDRIVSLQNRVKDTITHIDCYAEDIMHVVKLDRQRLQARSGEAITESNVTIMPEPSEPVHQEPQRQMDFALEPIQEEDESYPVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7V5</accession>
    <name>A0A194R7V5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_10773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="11">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7V5"/>
    <dbReference type="FunCoup" id="A0A194R7V5">
        <property type="interactions" value="1395"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7V5"/>
    <dbReference type="KEGG" id="pmac:106712455"/>
    <dbReference type="InParanoid" id="A0A194R7V5"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="456" mass="49997" checksum="576EBDEF87F3DE99" modified="2016-10-05" version="1">MATLLPRSLGLVENVFLKNGRKILAPTSGSRLTNKQQIRNLNVHEYISYTLLRDHGIPVPKFNVAKTKEDAVKFATELNTKDIVLKAQVLAGGRGRGSFKNGLKGGVRMVDNPETAGDIAGKMLNQYLVTKQTGAAGRICNMVMVTERKFPRREFYVAIMMERSFNGPVIIASSQGGVNIEDVAAENPDAITYEPIDIMKGITDEQICRVVEKIGLSDHAEEAHGMIKKMYDLFLKKDALLIEVNPYAEDAITGKYFCLDAKFRFDDNADFRQKELFALRDITQEDPKEIEAAKFNLNYIALDGNIGCMVNGAGLAMATMDIIKLYGGDPANFLDVGGGATAQAVSEAFKIILSDPKVSAILVNIFGGIMRCDVIAEGIITAAKNLNIQIPVIVRLQGTKVNEARKLIADSGLRIVPRDDLDEAAQLVVQLSEIVALAKKAGVEVQFDIPRYMIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7X0</accession>
    <name>A0A194R7X0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H2 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7X0"/>
    <dbReference type="FunCoup" id="A0A194R7X0">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7X0"/>
    <dbReference type="InParanoid" id="A0A194R7X0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.120:FF:000002">
        <property type="entry name" value="Ribonuclease H2 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="10">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="9">
        <location>
            <begin position="116"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="308" mass="35058" checksum="D9F4B78A3414E946" modified="2016-10-05" version="1">MTTRSQKKSNSTSSNLSVSQKRIENSWILLIKESLFENSSFSIITLPHPANGNFSKYCLDNVHNKMFEVMTYSEPYRSWFIGDFVKSDGSILMITPINPLFLVLPRLKEQCLNRAVPLNDLLSEKGFDKIIDFVKNMDNIGDLKGPAEMKAYKYNEEKTLNWLEERIHKVAKVLNEKNIHVVSGAVSSTFVSSNLNNDSIDEEFYLKYAHGIISEYLQEDLVEKLEKRFNFKPEIIETVGKKRKSEVDLNNSNKKAKNESTCEDFNDVKAGVLLNGSSETKKKPTAKEKARQKAASGTKTISSFFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R987</accession>
    <name>A0A194R987_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Broad-complex core protein isoform 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R987"/>
    <dbReference type="InParanoid" id="A0A194R987"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF106">
        <property type="entry name" value="FI01104P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="270" mass="30558" checksum="FC271A584F16FF9E" modified="2016-10-05" version="1">MLLSACSNYFKQIFKENPCQHPVIIFRNVKFEDLNAIINFMYHGEVNIFQEQLESFLITAELLEVKGLTDNAEEETSKTPIMLIDNTSLDLSSKSSRTNQDMVPIQTDEPINLAVAVQTNRDENIPDANMQKNLHDIIVETELQTEKVTPDESTNSSTRGPPLPSEEMQVDTQSTSAEDLSEKNNDSDLAKFRCQLCPKGFKHPTSLTLHKDSHAGKTQCPVCHRSFSRSYDMRSHLQRIHQGKQLTIKEIRYKGNSDSASVAKQFTPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9G5</accession>
    <name>A0A194R9G5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9G5"/>
    <dbReference type="FunCoup" id="A0A194R9G5">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9G5"/>
    <dbReference type="InParanoid" id="A0A194R9G5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="238" mass="26830" checksum="3C84C18CA1F9E480" modified="2016-10-05" version="1" fragment="single">RLASGVPCAQPLVASYDGTWPDVEYIWTHHSRDASCILGPNDVCAKYTYYFDGHVENSTYLCTRAVDSFGAAVTSGCYQQRNGSFATRVCFCRSVPGGVPCNEAPLTKNVPDYGASRERNDLGFLTFDLKTDLSHLFNWNVKQLFLYLTAEYVTPNNELNQVVLWDKIILRGENALLDFKNMNTKYYFWDDGNGLKGHQNVTLTLSWNIIPNAGLLPNIEALGQHSFKFPTEYTQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAW9</accession>
    <name>A0A194RAW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ14998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAW9"/>
    <dbReference type="STRING" id="76193.A0A194RAW9"/>
    <dbReference type="InParanoid" id="A0A194RAW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="158" mass="18453" checksum="7F2B52CD130F351B" modified="2016-10-05" version="1">MIPEDALREQVEKSLEKMPESSLERWKTFISIYDSYLRENGNAIRKIKYLIEEIKIQFCYPRLDVNVTKGFNHLLKSPFSIHPKTGKVSVVFKPNNARNMKLDEIPTIHSLLDDSSPDNVQHQNNMRNAVKNFQEVVFSLEKAEAIRKRNYASKFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB51</accession>
    <name>A0A194RB51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Dynein heavy chain 10, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_06893</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB51"/>
    <dbReference type="InParanoid" id="A0A194RB51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="18">
        <location>
            <begin position="84"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="18">
        <location>
            <begin position="226"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="17">
        <location>
            <begin position="407"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="17">
        <location>
            <begin position="548"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="849"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="1320"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="20">
        <location>
            <begin position="1463"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="21">
        <location>
            <begin position="1613"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="703"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KPJ14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1928" mass="218832" checksum="55761BD9DE2DB86E" modified="2016-10-05" version="1">MSEKPAKSDAVPEETEVMEEEQEEQEHMLTLEEYVLRDPMLFGDYRNALDEEEIRYYEDLLDYEAVYFLFQEILDEYSERVGKMSVVLFEDCLEHLTRTHRVLRMERGHVMLVGVGGSGKKSICRLAAFAAGCDVFEIVITRSYNENTFKDDMKRLYNQLGVDGKPTVFLFTAAQILEEGFLEFINNILMIGMIPALFGDDEKDAIINALRNESLLSSSSQRHNFRILEEGFLEFINNILMIGMIPALFGDDEKDAIINALRNESNDAGYGVGKDAVWNYFCSKCLQNLHVVLSMSPSGDVLRNRCRSFPGLVNNTTIDWQFPWPKQALLAVANVFLADVQKIPDEFRGIIVEHVVHVHLSVAVYSAEFLARLRRNNYVTPKHYMDFLTSYIALLGEKDAFIVAQCERLKGGLLKIEEANIQLEDLNAKLAVQKVIVAEQTHECEILLKEISTATEAAVGKQQVAAEKSAEISQQSEVIAEEKAEAEEALSAALPALEAARLALADLDKNDITEIRSFATPPEAVQCYYFSDPSPTEAAVGKQQVAAEKSAEISQQSEVIAEEKAEAEEALSAALPALEAARLALADLDKNDITEIRSFATPPEAVQVVCECVVIIRGIKDVSWKGAKGMMADPNFLRNLQEMNCDLITQAQVKAVKAHMKKSKKLDTMQQISKAGYGLLKFVIAVLGYCAVYKEVKPKKDKVEALEKEYTEAVNYLASLNREIDRLQRTLDGLNQRYDTAMLRRQELQEETDIMMRRLVAADKLMSGLSSEQKRWTEDLKALHVEQSRLIGNCLLAASFLSYAGPFSFSFRQTMIYEDWLGDVKERGIPLTEPFTIEKNLTNEVEISGWNSEGLPPDELSVQNGILTTRASRFPLCIDPQTQALTWIKRKEAKNNLKVLSFNDPQFVRHLEMAIKYGIPVLFQDVNEYIDPVVDNVLEKNIKVEGGRTFVLLGSSEVDYDPNFRLYLTTKLANPQFNPAAYAKAVVINYTVTVQGLEDQLLSVVVRAERSDLEEQRESLIMETSANKSLLSGLEDSLLRELATSTGNMLDNVELVDTLENTKAKAAEVMEKLELAEVTTKDIEKLRDGYRPVAKRGSILFFVLSDMAVVNSMYQYSLSSYLEVFSFSLRKAMPNVILAKRLKNIIDMLTKNVYDYGCTGIFERHKLLYSFQMNIKLEQNEGNVSQAQLDFFIKGNVALEKAATVCPATWIPSQGWQDIMKLSTDFSEVFAMLPDQIRTKLEDWREWFDSDTPETNEIPNGYRERLKPFELLMLLRCFRVDRIYLALTDYITATLGEEYITPPLDHYCDSLDMIFEQTTPFTPVVFILSPGSDPTADLMKLADRCGFGGGKFKYLSLGQGQEGAALALLEGAISHGQWLILQNCHLLVSFLRELEKQLELLTKPHPEYRLWLTTDPTPTFPIGILQRSLKVVTEPPNGLKLNLRNTYFKMRPHALEECAHPQFKKLVYVLAFFHAVVQERRKYDKIGWNISYDFSESDFVVCMQILQCYLDRTTGVVPWATLKYLFGEVMYGGRVIDDFDRRVVGTYMDEYLGEFLFDKFQPFHFYHDDVFDYYIPPDGEREEYIEFVDSLPLANTPEVFGLHPNAEIGYFSQAVRDMWSHLIELQPQTSEGGGAMSREDFIDSIAVDVLAKLPAQYEVWRVRKQFEMNITPAVVVLLQELERFNRLISKMHSTLSLLRKALAGEIGMDAVLDNVASSLFNGQLPNVWRALAPATCKGLGGWMDHFMERTKQYTDWASIPPPPQTHTRALLATMEEPIVMWLSGLHVPESYLIAHVQTTCRARVWPLDRSTQYTRVTKYTAVPDIEQRPDSGCYVRGLYLEGARWDLEDGCLRRSHPKVLVTELPFMHIIPIEAHKVKLQNTLRTPVYTTSQRRNAMGVGLVFESDLWTAEHISHWVLQGVCLIMNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBP6</accession>
    <name>A0A194RBP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBP6"/>
    <dbReference type="InParanoid" id="A0A194RBP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="294" mass="34797" checksum="74A76D44A78F0C1C" modified="2016-10-05" version="1">MTGSITKKASRWIGGIYDYGARAWKWGGELRRMHYQSFSKMKRQSPEELKWNCIAMMPELLYRWAPRSCIEARQYICQKKLRKVPKTKLKDLRRRWQRMGKINEITAPSVSREVDDPRTNDVTTNPVDNPKAFDLRPAPLYGPRGNRREPNPIRNHQKPYDLRPNELKKRSRPNARRRLTRPFPGYKWNRHDPEASFRYNSELLRSGRTGLSPQQVNGHLARLRHLRDRQIRRRRLRENDDWLVNDVRQVLVPTHARTYTVDNNISALHPKAIVEEFDMMPRPIVLPRPARGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCB2</accession>
    <name>A0A194RCB2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Netrin receptor unc-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCB2"/>
    <dbReference type="STRING" id="76193.A0A194RCB2"/>
    <dbReference type="InParanoid" id="A0A194RCB2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000021">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="181" mass="19304" checksum="B45C74C6AD94C884" modified="2016-10-05" version="1">MSPSPTSVEAGLTASLRCSPPEAVPPPRVAWLKHGTPLQQDHNVVISAEGNLVISRATLQDMANYSCVAENIAGKRVSEPALLTVYVNGGWSPWGPWTQCRCGGRATGGQRRTRTCTEPHPLNGGAPCQGQAVQRTNDCVPCQSASLKLQASAVYEEVGISKLIHIALKSELTPCMMNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCD4</accession>
    <name>A0A194RCD4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCD4"/>
    <dbReference type="KEGG" id="pmac:106710666"/>
    <dbReference type="InParanoid" id="A0A194RCD4"/>
    <dbReference type="OMA" id="CCEDMTA"/>
    <dbReference type="OrthoDB" id="7215202at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="24759" checksum="F446E8592699E44A" modified="2016-10-05" version="1">MLSRGIIEIVLLSAAAGYMDLPVRKLPEIDLNKPNNFDATTCEKFEQNAYFDPKEIVDSLWKIFYYWANGVEISTILFSLPSDKKISNFRTFVETYNPDLSIEWDKAALFMEPRPDVKVLLVSRDRPGSYLAVVKGEKHDKGRDVPNVHATDVRMKTVGRYMGIMNCDDGTAFALARLHDMPDTYHHCKAAAQLLGFNVNTGESYITHVPELRPLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCH8</accession>
    <name>A0A194RCH8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCH8"/>
    <dbReference type="InParanoid" id="A0A194RCH8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="13152" checksum="6DDBDB7236AC6A01" modified="2016-10-05" version="1">MLSYPMRREVLKTFVDVFLPGSSGRPERGNPHSTCWVRGGICVKVRHCPIMNLDSTVPGCNKNWRVCCRVQSMLSPTVGVARSEQLQYDLHLQDVDSPLMETLAVNNKNIFENLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDA5</accession>
    <name>A0A194RDA5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDA5"/>
    <dbReference type="KEGG" id="pmac:106710614"/>
    <dbReference type="InParanoid" id="A0A194RDA5"/>
    <dbReference type="OrthoDB" id="7251706at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="29175" checksum="A628C8DD61295DE5" modified="2016-10-05" version="1">MSEQDKKSNPPALGGPSVLVVDQTQGSRQKQSFRATELQQDASELHHKRSRAFGVPSVGEELKDICQEANGSTDPDNKEEKEQKEQKGQDVVSYDKQKQMLTKKLSSSHNKHDHPENIQYETIALTAVNVENKIELDTKASGTVAGVVTPQPTPSTTTKESAPQPPESQPEESKLQDTKLQETVNVMVNEECIKDEITEQPKADIDEKQSDWSYLEEEQAGGLPRETRASRVSRSVRTFFCCGVPYEAPSEDDVSVENYVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDQ9</accession>
    <name>A0A194RDQ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin-like protein CG14535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDQ9"/>
    <dbReference type="FunCoup" id="A0A194RDQ9">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDQ9"/>
    <dbReference type="InParanoid" id="A0A194RDQ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="kinesin-like protein CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="KPJ15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124983" checksum="7FE3EC131983A873" modified="2016-10-05" version="1">MLRVGALGEGPFTSGTQTFSLDKRKRQVTLCETAPSASAPEDRKVGVAAPKMFAFDAIFSQDDSQTEICSSALTDVIHAVINGTDGCLFCFGHAGLGKSYTMLGRPEAAGSLGAIPCAIAWLFRGIAEQRHKCGTRFSVRVSAVELCTNTNQIRDLLAPYQNDTEQSPGVYLRDDPLFGTHLQNQSELRVHSAEKAAFYLDAALATRGAKEEGKDSHLLYTLHVYQYSVGGKGAVAGGRSRLHLIDLGNSERGKSNGGIPLSGLGNILLAIFNGQRHLPYRDHNLTHVLKECLGSLTCHTAMIVHVSPNIQNYSDTLTTLQLASRIHRLRRRKMKYSSNNNAGSGGSSGEDASKPSSSEPDPSSSDLSADTVIYVGPMDDATDGEHPPVYIPHINSGDNRCVLSKALRGSAAEQRHKSSLSKVIEEKSPIHKLHSSPKSSPMKTGIQPVNQTPKSSPVHSAASKATPLKKTCVKSYSEEGKSSSDEHWIDGPRISKSRLVEARHIIKETQVKKRETWIDGPMQESKTPLQFESVPVQPPTIPLQVGVLSSHGNESLGYGYMDNHKKNMIRKWVENQTSQIHKSRHNSPSHKIQTGHRDPGVRIPDDPETTHKMEPVKDSSRRIHVEESTIRTGLKTGSKGMMIEEENIGPPFTDHTLRRSNSTKSATKNEQDDDDDSEELAEIPPALPLLQPSSLSSREVSMESLDSKYKERLRMDDELLSNRSRDIDTHQISRLTGDDEDDMLEIIEVEEPLEPVPMQDSCLQVTEEDIAFCMGLAEHPMAGMEQEDGDDHPLRILSQENLTVASTFTDTLSLYSEVERQLRNESYLRQLGFYAEHFSGDQPLADINPHESLQSSRSRIDDILGLTELYGSRRVLDGNDVPNPRIAPQFQSLSLCNVRDTEEYHGDGSVYSEPAYRPSDKICNSCKRSMSRPGSAVDDCAYQDLEVPHNDYGPFERYRGNDITDARIASLRHPDGASDPNLREEKRIPGNGAPSSTFRDLKSNLHLEVTPPVVTTEPRIDKSEKGDKVVARVVASSKPDGYDSGHESTPRTGKHSPAATSRRAESGYDSVPRDSDASSLDSYPTRRAAVARAHAKKHTTAKYKQHSDRSFCSWLRNPFTCKYADTDPEISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE49</accession>
    <name>A0A194RE49_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE49"/>
    <dbReference type="STRING" id="76193.A0A194RE49"/>
    <dbReference type="KEGG" id="pmac:106709691"/>
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    <dbReference type="OrthoDB" id="6344011at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="159" mass="17246" checksum="42949B4DE84B1330" modified="2016-10-05" version="1">MGCGSSGQVISSQDTDKNGEGNSNGKHVNNGHHDNELPTVVLPDTPVKPKPPVAYEIPLEEFTDGRPAASPPPHLQRLLQPPSADISLPRIEEKLAEAEQRRLTILQQRANSAQKRIQKTMRSLPDSGNFGMIQNTEGNHGPNTLPIPPEPGVCEDKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF64</accession>
    <name>A0A194RF64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-2 adrenergic receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_13637</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF64"/>
    <dbReference type="STRING" id="76193.A0A194RF64"/>
    <dbReference type="InParanoid" id="A0A194RF64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004937">
        <property type="term" value="F:alpha1-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1612"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1678"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1707"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1723"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1779"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1824"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1914"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2069"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2133"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2179"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2288"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2387"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2419"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2431"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2456"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2484"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2515"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2575"/>
            <end position="2615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="4035" mass="458427" checksum="1F0AE90FE5D2ECB4" modified="2016-10-05" version="1">MGVSDDLAPSFTQKPQLRQEDDGNKLIFECQLLASPKPEISWYRSDELLKEDNRTAFKIQSIANNKFLVVLELDDVIETDAGLYKVKAKNKMGEVAASINLNFSPADEEKQNRQVDGKAPTFARKPAIRQEDDGKRLIFECRIEATPVPSVVWFHNTTEVKPGSRHKLTVSKDGKSYYASLEINNVTVEDAGKYRVTAKNELGESNATISLNFDSDEAPVPEDSIKPTFTERPVIRQSEDGTKITFECRCVGKPKPTVTWYHGKKIVKESNRYKITLEEDQTLYYMARLEIIGVENSDKGEYRAVAKNKYGEGVAKINLNFEGGDKPKIPAGKAPRFPKKPTIRQDGDLLIMECILEAHPMPDITWFHGDTEIKDGAKMKMSRKAIGKDTFNLTLEILNPTREDGGNYRCNAFNVFGESNANIALNFQGGDDENGFAPSFIEKPRIIPNEDGTLITMRCVCKAKPAAEVTWYRGTTVIKASSKTQIKSTVIGEDVYELVLLLSNPTAADGGAYRCYVRNEFGESNANLNLNIEAEPEPEGEGPSFVEKPTIQSKDNGKLVIMGCKVKASPRPTIVWYHEGREIRDSSKIKTRVEVKEDIYTIILELIDPGIDDSGLYKCNIKNELGELNANLTLNIEIIPVIKERPKIIKIVKKKTVIVECKVLSKFAPSCTWFKEASAVKEDSRHTVLIEPLREGEFTVKLEISNISQQDKGSYKLVARNEKGEATSQQVEITDIPEEKGDKPYIIKHLRSLARKENEEAEFLAVLKTSDQSCRCTWYKNSTVIRDSSEVNTSFDGTNARLIIRKVSTKYVANYRVVIRNEFGEDESSADLTLVEEKKKKKEEEEEETTVIEESEEEMSIVEEKSVIEQNHVDERKEEQIQKQEEEMQITQEKKSSAKKVTKKEETKVEESRQEMKIESKKTEAQVEVKKNEAKKAEAEVEETRKVLEKKTAKTEEEKKALLEKIEERKKKPEPEPEVKIEGIPKLKPVKPKEEETKAAEEKKETTKKVGEKKKVVKKKVVSKKEADDEFEFEDDYERPVLEKYEKITPTPLYKKPKKDDIPKGKRASMSEGIEIEEVESEEEPSSAGPVPDKKQKTENKEKVEDETKRLSIKKGIPKPEEPVDELSKVKLSKGPTKPDQVEPEESQVAQVKKLAKKPEEEKEYVDDYEKPDLEKYDKISPTSTDKTKKQNGVKEDEMIVDDYEKPELEKYEKITPTPKGKRGSKEIQDDVDIMKGKIKPKDKEEEPQMPTLRKRSVPKDKDEDKKPEEKPKKKTVKKVEPGTKKRSSIKEKEDEFEFEDDYERPVLEKYEKITPTPLPKTRKKDDIPEGKRPSISEKIESIESDEAEISEPVSDKKTKTDSKEKVEDEIKRPSDKKGIPKPEDLIDELSNIKLSKGPTKPGDEKLEEPQVAQPDEEREFVDEYEKTDLDKHDKVSPTRRDTTKTRKDLPEDEMIVDEDDRSESEYEKVTRTTKSKRGSKDVQDEVDVMKGKIKPKDKEEEPQMPTLRKRSVPKDKDDDKKPEEKPKKKTVKKDGPAPKKRPSIQEKEDEFEFEDDYERPVLEKYEKIAPTPLPKTRKKDDIPEGKRPSVSENIENEYVESEEEPSIAEPVLDKKPIAANKEKGVDETRRPSLKKGIPKPEEPVDELSKVKLSKGPTKPDQVEPEEPQVAQVKRLAKKPEEEKEYVDEYEKPDLEKYDKLSPTSTDRTKARNDKEEDKMIVDDDEKSELEENEKVRRTTKVKRGSKDVQDEVDVLKGKIKPKDKEEEPQLPTLRKRSVPKDKDDEQKPEEKPKKKTVKKVEPGTKKRPSLKEKEVVEEEFVDDYERPVLEKYEKITPTPIQKKKKDEKKPDEEVPSESFTSRRPSAKDKPEPMDVDEEVQLSKPKAPSKPAPEDVSLTHKTPAEITPTEDEAEAKLNVKKPEIVEEKTFKKPSVKDKDKKSEDTEESVSLTKPRTKTSTTAPEDASLTHKTPAKKEPTEGTEAAALKVKKPAVVKKGVKDDKEEPLAIQGGKFEIPKLKKTVKKTTDKPKQATHSEQEIHDGYELDFVDDYERPVLEKYEKISPTPTVKEKKEKEQKTMKEEIKTESRRSSIIENKALKLTKETAESRKSSISSISEQQQVSTVRKGSLKTAVRESEVNELEQIKLKDDTTKGKPEEKPDEHTEHKTETPFPWRKSKQNTEETNDKSTPKRSVSLDQPRKSSFPWRRSSKGEDGEDDTETEINTTQTKRTLHKTPEEPTPTTRRTSKHDEDAIEPTSRKPTDISSSPLDNENGVDIPNTNKNNEYTNNEKDTYPWRRSSTTKEKTETPERKESIPNSETSEKVEVADINKDKIPDKPTEPSYPWRKQTNKEVPIFITPDDETKHNEVSFSWNVIPEIPQAEQTPELEDKFKPTLLDTRDTVPWRRAKSPQAEDKEQSKPTLETPPSSTPSDEKVAAKEEKVEAEVKKAKATTLKKKAEDLPEIPDYERPELEKYEKISPTPTTREKPEKDKPADKPKIAEVKAPEEPPAPAAPKIKEPEEKPAAPKIEVVREKSPKPEMPRKPSLSPAPPGRRGSLIPPPEEMGRRPSLIISDEENRKLRPGEVIEDKKVTKLRPGEVLDEKKRRKSGDSRRPSVQDLEGLINKPSTPLRPTGNEGPPVIVDAPESNSAVEDQVGYLSILVEGTPPPTFKFYKGVTEIIEGGRFKYITEGDTGRITLCMRKVKPNDEGKYKVVVSNIHGEDSAEMQLYVSDASGMDFRALLKKRKYQKWGEKNEEPDWGDLKEVEKPIPPLKKVEKGLETGYFEDDGFIVVVSEGLEIYRFPADRRRNSSNWSWGIYQIRRRMSLPEIIPDWPALLEAVKSKKPESFLKPLVDQSAKEGKDKKVTFEAIFTKPNAKPKWFFRKDELFPGSKYKMTNEGDSYKLIIMNPKVEDTGKITIEIGGVTSTAFLQVDEPDPTYSFTKHLKKTLTGYTKHEVVLECAVSNSLAIVSWWKGEKKLEDSDEFQTSKDLSGVCRLVIKAAKLEDAGKYMCKIEKQPDKTECEVKIIEYPYKFTKVLKSQQAIEKDTITLLCELDDAMGDVKWFKNDQPLKADKRISIVKEGRKRKVVIKDAKVTDAGNFKCVSNADETACELIVKYSNRFNKKLKDTEAVERDKVVLEVELQDQTAEAVWSFNGTPIVPDERIEIKNLGGGKHQLIFNKLEMEDDGEILCESGKLTSSCKLTVKKGESKPSIECPDEFNGPAGHPFVIEVPYKISGTRQTPIEAKLFKDGKALPAKEVEVVVEQEKILFKLKKPTREGSGRYQIKLSNAQGEDSKDVTIIMQSAPTPPQDVEVSEVFQTSCVVAWKVPQDDGGSPIVKYVIERQDMSLKAGWDNVAEVAHGQPTKYKVEDLVAKKTYKFRIRAVNKIGSSEPGLFGKPVLAKDPWDEPSKPKGVELKDWDKDHADLKWQKPDSDGGAPITGYVIEYKEKFGKDWVKGKEVDGDCLEATQDGLKEGCTYEFRVRAINKAGPGEPSDSTKPIVAKCRFVKPYIVGEGLQSMIIKKGQVISFDIKYGGEPEPEVRWMHGEEEIRDDGERITIDKYERNTVLTVRKTTRIDSGKYKLVLTNSSGTCESIADVVVLDKPNRPNGPIEVVEIRAEKATVKWQKPDDWQGSDITGYTLEKMDLDTGNWVPCGECGPEPTEFTVKGLTPNHKYKFRVRAVNKEGESEPLETDGAIVARNPYDPPKAPGKPNIIDYDNMSVTLQWEPPSDNGGRPILGYVIEMKDKFTADWIEVGKLTEPKTEYKVEGLKEKMIYQFRVKAYNKAGVGDASQPTENHLCKHRNLKPRIERSTFKSVIIKAGRTHKWSVDVIGEPPPETTWSWRENIKLVNTERIKIENKEYHTDFTIVNAVRRDTGKYTLRAENCNGFDEETVELTVLSKPSAPKGPLEVTDVHAEGCKVKWEKPEDDGGSPVKEYELEKMDLATGKWVRVGRVAGDKKPLEMEVTGLEPGHQYKFRVTAVNDEGDSEPLETERAILAKNPYVVVDASKNNIRCTNLPTRPVKYHDHTEDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGT0</accession>
    <name>A0A194RGT0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_10248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGT0"/>
    <dbReference type="InParanoid" id="A0A194RGT0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="111"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="428" mass="46769" checksum="BD369A5309D11234" modified="2016-10-05" version="1">MRFEWQIVRLVSHHNGHRSFGDIRRVCVLCGTCSRCGDSLAASKKKTGTAGRQASSEAAKVIDPATLPEGRRRVDAMAELAEAEAEWGASPVQLVRPLVLAVCAAPVAGAAALAHCALLAALLKRSTNGLFYILIQLAIADLLLLGTTIAPELWSYNAGTWQFGRSACIAYRGLNVFATTASLYLITTIALHSLATASLEEKEARKSSGKRDDLDEDDEIRSSRHSLVTSDTSTPPRTMNVDYRLTNTKIRIAPPVLFVWVLSASLSVPDFVLSTTVHLDHNVVLCTLVDTSHRLNMHSLLAIFNLFLPIIIMSAAAILILIKLKSKKGHSQFDETFPALKLSLCLICTYVVLCAPRSIVTVYSLYSTSTVENEYAVEQPGYVLTLVNLVCVCLYLVANAVRPLLCIILLPKLRKVFFFGLRNSNVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHJ0</accession>
    <name>A0A194RHJ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHJ0"/>
    <dbReference type="InParanoid" id="A0A194RHJ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11384" checksum="DF81CAC0ACB41583" modified="2016-10-05" version="1">MSIRGVQDGSRSPRIVTDSFFDDEDPDRLPSALGPDGFALTYLPDIQYQLSYSDQYHVQRIVNRIEWPLWGKTSSDDAKIIGCVSRLAGSVRDRRRHDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIW5</accession>
    <name>A0A194RIW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein takeout</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIW5"/>
    <dbReference type="STRING" id="76193.A0A194RIW5"/>
    <dbReference type="InParanoid" id="A0A194RIW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="333" mass="36615" checksum="51D1D1C5C3770464" modified="2016-10-05" version="1">MCTAALEAVGAKVHKRIVVRDANVKLKCAGQLSADLMEAHSTTHEMEMITNHLIGMHSSEIAKEVQPAVETALAMVLEDIANKFLKHIPSNMIQSDLDKNSEGHETIPIGGFMCPREEEALSECLKDALNVYIPELATGLPKYGIPPCEPLMIPTLTIQQAAGPISISSTYTNVSVKGPASMRITKVEVNSSKHEVIAKLYIPELRMKGHYNLSGKLLLLPVEGDGKFSAKYGDIYAVLTIALGRLHRENDVDALACEKLDVKFDVGSASINLENLFDGDNELGNTMNTFLNENWQKLAKEFQEPMEEALRDFLKPLADHAFGTLNADDIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJL6</accession>
    <name>A0A194RJL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJL6"/>
    <dbReference type="InParanoid" id="A0A194RJL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="322" mass="36647" checksum="CCC7E6E7B02EA87C" modified="2016-10-05" version="1">MEENISSKIKLEDKYKPDKSQTENVISEVTSGEKINSNTSCIKQIDQNCEKQSSEDNNMNNNCHLPSTIKTELNNNFNRNIATFNNKMNCLNKLPPKTEEDNKITDKNEENTDRNKASDTFNKVKGTKEETMSKKINEATKKNRPQVNQKYATKVVKNNQNKSERPKKIKITINITYNNVHSKNNVTSTNVDGDLSFLDDFDVDEVVESLFNSKEQNNLNIKTNIDIEEKITENSKKRKTTSTEQINRNHKESCSKHTSRVDNKTEETKKANIEKEKSPASIATENNKGKNLNGEVNCSVIPKKIDKKSESGIISTESKNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKW7</accession>
    <name>A0A194RKW7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ETS-like protein pointed, isoform P2/D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKW7"/>
    <dbReference type="STRING" id="76193.A0A194RKW7"/>
    <dbReference type="InParanoid" id="A0A194RKW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08533">
        <property type="entry name" value="SAM_PNT-ETS-1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000014">
        <property type="entry name" value="Protein c-ets-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="4">
        <location>
            <begin position="168"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="41501" checksum="D60E2A19F61F8D7D" modified="2016-10-05" version="1">MINISLISVAVRLNPHQSLCQKHNEMYDTFDTDQGARDASLGNVLIDRSEVKSLAADRPTPTITTLLEIARHGLAGTVGTSPSEGVSVGWGREGQQRGEWGGGPETPVPDRSAHLVEAAQIFVAATVAIAGMGIKVMMKAFNKPKDIPSQVPPLTPGTNKKMAEALKATFASWEKEQLRLGVPKDPRQWSEAAVAAWLRWAAREFSLEGVALQQFARAQGKDICAMGRDEFVARAPAFMGDILWEHLEILQKDVEKERSLIANVPPNMYESNVCLPELAEYIPPPAHHYNNNNTDFIKAVTVRLSVASVGIVNFHVLGATQALPTNATGPSASRLTHTRRIQYFAIAHINKAYTHCIGAIRRHPRCRKPFGEHPCCALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL44</accession>
    <name>A0A194RL44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RING-box protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL44"/>
    <dbReference type="STRING" id="76193.A0A194RL44"/>
    <dbReference type="InParanoid" id="A0A194RL44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="53" mass="5989" checksum="60AFA635374F7C33" modified="2016-10-05" version="1">MSGEDCEVLDRGDGEGQKSDKMFTLKKWNAVAMWSWDVECDTCAICRVQVMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLK1</accession>
    <name>A0A194RLK1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylinositol-4-phosphate 5-kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLK1"/>
    <dbReference type="STRING" id="76193.A0A194RLK1"/>
    <dbReference type="KEGG" id="pmac:106720999"/>
    <dbReference type="InParanoid" id="A0A194RLK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="19009" checksum="E1D5248D1B06290D" modified="2016-10-05" version="1">MIDSGDNSETATVDIKKQVKEILVIQDEGFFVHDTGDTYNGSFEVKKKDRSIKMHGPGIYTTAEGDAYAGYWENDKLGVNDEVMISYQDGSRYQGLLKDWSYTGRGRYYYPDGTILQCEFVDNCPVGNLTLIDPNGHTWLGKAEHGYCWFQPVNHLYVMLETRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNP6</accession>
    <name>A0A194RNP6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein PET100-like, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNP6"/>
    <dbReference type="FunCoup" id="A0A194RNP6">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNP6"/>
    <dbReference type="KEGG" id="pmac:106720721"/>
    <dbReference type="InParanoid" id="A0A194RNP6"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8774" checksum="6FA47A5917E89BDA" modified="2016-10-05" version="1">MGNWKLEVGRMAMYTTFPVALFFVFNQPKYFEEWVTNTKRQIFPPENKQDREDIQKLIQDMRKKQMRALEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRQ5</accession>
    <name>A0A194RRQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromo adjacent-likey domain-containing 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRQ5"/>
    <dbReference type="STRING" id="76193.A0A194RRQ5"/>
    <dbReference type="InParanoid" id="A0A194RRQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053032">
        <property type="entry name" value="BAH_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576:SF1">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="119"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="30537" checksum="D515A06192B43D2B" modified="2016-10-05" version="1">MDEATLLVEAACASPTPSAAGEASEAGEAAEAGKLCVQSPAGGARGGRRRRSGGRRARRAPAPLTPLALQPRPPRPPPRWSNGWNWDGEHYVSKVYLNNDSRLDRTARCWARMWHASGDRVARGDCVLLRASLARAQPFVARVASLWENPDDGEMMVSLVWYYRPEHTERGRQADDAPDEVFASRHRDANSVACIEDKCYVLTFNEYCRYRKRLKASEEGITMAPSIVPPLPAGEVTPTLAPNDTKLPPSVSPELVLFCRKIYDFRSKKIHMPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSH2</accession>
    <name>A0A194RSH2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat and FYVE domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_06083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSH2"/>
    <dbReference type="InParanoid" id="A0A194RSH2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15728">
        <property type="entry name" value="FYVE_ANFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000104">
        <property type="entry name" value="Ankyrin repeat and FYVE domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049764">
        <property type="entry name" value="ANFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="927"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1298"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1475"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1568"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1752"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1855"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1888"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1993"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="2054"/>
            <end position="2114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2118" mass="232152" checksum="E14122350ADC07CD" modified="2016-10-05" version="1">MYMQMAIANMQKGKIIFFFIAYMIFETSLGIGIDYYYEVDTKKSNNISSNANYSIHKTYINGDESDIDDERNEQVKEFYYVTKITTEAITKKANVSFLHSMNSNPQNGFINENNFTTKPILDIFNEYEYIYDDEKYQTRNGDFMPKGKEVPMSGWKENPRIYYSRNDTRKMKKNKSNLVKLKLLDYYTLEPAATYVYMEEDDKYAEENGSVWYVPQDIPCWELPILYGELGYKEQMSDVFSIHRSYLKNVLRQNKMKKVSRKDGFTPGTQMFNKWCGIEPCYGDHTLCLFPDKTISIFCEKGYTVKTPTISEQIALVNTVNSMRNRIAAGESIRYSHLPQAANMMQITYDFDLEKMAQAWLSQCLPGPAPCSALEGNYVSELECMKYMQKCCLNSYKTDTNCTPSSECFVLAVVGCIHAWYWSAGENLSETDIQCGHIEPATFNTVQLIWANSHKIGCAFGVSRNGDVRVVCNFSPGAPYFLRRKFYCGLLPHRDMTSALDATVDFTNLTFLSSIGINLDEINQTNTNYDAKVQVVDERLLAEINSIPKTASHWGVHSLSSIYQEGWVSRLLGKLQNGTKGMVARVVTQFTFFEESEARCDTEEPVYVKGEPASLCVERGRRYPALCYHYGDPTPGYRLVAIIAPITLFSLILYDLFSGALTDIVNAMSPRGELPLELALRGRSASIATTLLQHCADPDARGPRGRTLLHRAVDSRDAFSAKFLVDNGADTSLTTKEEGDTVLHLIAALTSSSCEPDTMEQMVEIAETVVAKGADINRQNRKGYTPLHQSVISRNHKVFDLLLKQPNLDTNLRTLADEHPPLYYALVDDRRASISSSETLVMNGSNPFDTPVTNKNAFTEDPVEGKTENIIERGFAAKLLEKGCQPNPLYSGSGDSLLHILIQGWFEDSAVFLVSHLNGDLNHGNEAGVTALHAACASGLTRLTAALLEHGARHNLQTAYGEQEDTVYRQTPLHLAVLNNHEGAVLAILEHKKLIEKGEMPATDRSNVSLLPNLNMKNSEGDTPVSLALTEGHKNLVKPLIEGGADPNVRNGKGFTLLHQAIVEEDSRISIYLLDQGADMDALTEAGETPLQLAIHCRLGLVVEALCVRGVDMSRLDAHGVPPLWAALDSGQEEVASILVRNGADADCWGPGPDGCLQTLLHKYVCDSYSDPNKKKTPKITLLEHGANINSKDAEGKTPLHIAIENQHAGIISLLLSQPGIDLSARDNKGVSPFAAALTARNNKAAQAILEKNPSAAEQVDKKGRNFLHVAIQACDVESVMFLLSVEVDVNSRVQDGRLTPPLHLAAAAGNELLLRSLLLAGARPNDRDAENTPLHQSVISRNLKVFDLLLKQPNLDTNLRTLADEHPPLYYALVDDRRASISSSETLVMNGSNPFDTPVTNKNAFTEDPVEGKTENIIERGFAAKLLEKGCQPNPLYSGSGDSLLHILIQGWFEDSAVFLVSHLNGDLNHGNEAGVTALHAACASGLTRLTAALLEHGARHNLQTAYGEQEDTVYRQTPLHLAVLNNHEGAVLAILEHKKLIEKGEMPATDRSNVSLLPNLNMKNSEGDTPVSLALTEGHKNLVKPLIEGGADPNVRNGKGFTLLHQAIVEEDSRIAIYLLDQGADMDALTEAGETPLQLAIHCRLGLVVEALCVRGVDMSRLDAHGVPPLWAALDSGQEEVASPETSLATFLIRSGCDVECARRPGPGGEGADLAAERHTPLHLCCTWGLSDVIQTLLEHGANINSKDAEGKTPLHIAIENQHAGIISLLLSQPGIDLSARDNKGVSPFAAALTARNNKAAQAILEKNPSAAEQVDKKGRNFLHVAIQACDVESVMFLLSVEVDVNSRVQDGRLTPPLHLAAAAGNELLLRSLLLAGARPNDRDAEKRTALHVAAAGGHAAIVSALLSGGAECGAADARGDNALHVAAREGHAAAARALLADSDIDAAATNLKGRNPLHELCWCKKDNAATICEIFLEFMPDYPINKTDLQGNTPLLLAYMNGQAAMCRVLVRAGACLAQENKDGLSIFNYQVATKQLLHRLLDALPSEAPWAESDLCQECGTKFTLTMRKHHCRHCGRMLCNKCSNQDVPILKFGLNKSQRVCEICFNVLQVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB16</accession>
    <name>A0A0N0PB16_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KQ461183">
        <property type="protein sequence ID" value="KPJ07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB16"/>
    <dbReference type="FunCoup" id="A0A0N0PB16">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB16"/>
    <dbReference type="InParanoid" id="A0A0N0PB16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857422" description="alpha-glucosidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="587"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1132" mass="130734" checksum="F1FB2AE7728B25A5" modified="2015-12-09" version="1">MRHLYILPLLFLVVKAAKNTRDLDWWEKTIFYQIYPRSFMDSDGDGVGDLNGITSKLEYLKELGVGATWLSPMFKSPMYDFGYDISDFYDVHDEYGTMEDFDNLMAKANELDIKIVLDFVPNHGSNESVWFEEALKGHEKYFDYFVWEDGVVDENGVLHPPNNWVSVFRKSAWEYREEVGKYYLHQFVIGQPDLNYRNPAVVEEMKDVIRFWLNKGVAGFRVDAITHLFEVDKEKFGGKYPDEPLSGNSDDPDNYDYLNHIYTINQDETYDMVYQWRDVFDEFKEMDGLTRVMMTEAYGSPDIIMRYFGEGEREGAHMPFNFVLISDVDGSSSAAEIKYAIDKFLTFKPIDKMSNWVGEEIGMEDGYVSWEDTVDPSGCNTDDPINYWTASRDPERTPFQWSADKNAGFSTADKTWLPVAEGYETLNVEVQRTTERSHLNVYKALAKLRTEPAFSHGRYDSVALNSDVLAFKRWHDGEIYVAVINFRDEIYNLDLTYFENVTGKLEVIVTSVQSAKTKGDVVEAENIQINGREAFSHLMYCIGYLNLKYRPRVNIKGLFLLPILCLCARGAKQDRELDWWETTIFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKELGVGATWLSPMFQSPMYDFGYDISDFYAINDEYGSMEDFDNLISKANELGIKIILDFVPNHGSNESVWFEEALKGDEKYFDYFMWEDGVVDENGTIHPPNNWNSVFRKSAWEYREEVGKYYLHQFAIGQPDFNYRNPEVVEEMKNVLRFWLNKGVAGFRVDAVAHLFEVDKEEFGGKYPDEPLSGDNVDDPESYDYLSHIYTKDQEETYDMVYQWREVFDEYKEKDSFTRVMMTEVYASPEITMRYFGDGEREGAQMPFNFNLITDVDGSSSAAEIKYALDKFLTFKPVDKLANWVAGNHDNNRVASRFSPELVDGINMLVLLLPGVAVTYMGEEIGMVDGYISWEETVDPQGCNTDDPINYWIKSRDPERTPFQWNSEKNAGFSSADKTWLPVAEGYETLNVEVQKVAQSSHLNVYKALAQLRTEPAFRHGRYDSVALNSDVFAFERWHEGTSYVTVINLKDKKYTLDLTYFEHVVGQLEVVIRSVYSPKNTGDILDAENIQIEALEALVLKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBL7</accession>
    <name>A0A0N0PBL7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_04229</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBL7"/>
    <dbReference type="STRING" id="76193.A0A0N0PBL7"/>
    <dbReference type="InParanoid" id="A0A0N0PBL7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="26763" checksum="CDD728153CFA5BAE" modified="2015-12-09" version="1">MEIFSTNVSWNKNTNHLPRRHPPDPDDSLMSRACSNLCKYSECIAVRAAGGGRRRAEGGRHTGVTRAPPAGSPINPRTLPFIVEDERVPYSSLASLVRTPCGSAQANAQHHFIRITFDCSMGEVKRFSRAEVAQHKGRAGGRLWLVYKDSVYDLTDYLAEHPAGDAIILEEGGEDVSKAFDEVGHSGDARDIMAKYKIGEVNEDEKYYDEKGKKKKRVVEVQPEDGGGGGSRSLLGICCCGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC34</accession>
    <name>A0A0N0PC34_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460668">
        <property type="protein sequence ID" value="KPJ12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC34"/>
    <dbReference type="InParanoid" id="A0A0N0PC34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="6824" checksum="E10E72982CFB26E1" modified="2015-12-09" version="1">MLGITGCKEELNGVLVKEELVNGCCVLSGVVLKGEGVVDGGVGTVGGTVDGVPKGLVEGCVPKGEGVGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCE0</accession>
    <name>A0A0N0PCE0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCE0"/>
    <dbReference type="FunCoup" id="A0A0N0PCE0">
        <property type="interactions" value="1320"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCE0"/>
    <dbReference type="InParanoid" id="A0A0N0PCE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000634">
        <property type="entry name" value="Peroxisome assembly protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U-box" evidence="15">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="285" mass="32306" checksum="5C831DCE540F2A6E" modified="2015-12-09" version="1">MAVYAAHLTRTLQGTPSIFQIAAQEALGATVKPALKRLAEYLAVVNPQRYAWCERWYDELYLLLDFCLQYHYLKHYASSFSECFYGLLRVPISPSNEFHSGVRLPELLEKGSLLLLVLVPYIKDKVEQIIEKWREDNEDGKLGKSTSNQARKAAIKLYSIAHFVLEAAKFIQLARYLTGRTLSPTLDFALLGLTVKEAPPPEPEEYCWSDLFKSLWAGQIGDQAVRWKNKCPVCLQPWKVPTVLPVSGFVFCYGCVSRHVRANGTCPVTKLPTTERTLVRLYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCF3</accession>
    <name>A0A0N0PCF3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460652">
        <property type="protein sequence ID" value="KPJ12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCF3"/>
    <dbReference type="InParanoid" id="A0A0N0PCF3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="10185" checksum="8E07B142158A177E" modified="2015-12-09" version="1">MCRELLQTIKKRKVAYLGHVLRHKDYDLLQLIMMGKIAGKRRTGRRKKSWLRNIKEWTNIASVEHLFRFSQDRQKFTEVTAKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCJ7</accession>
    <name>A0A0N0PCJ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of DNA damage checkpoint protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAX-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCJ7"/>
    <dbReference type="STRING" id="76193.A0A0N0PCJ7"/>
    <dbReference type="KEGG" id="pmac:106711993"/>
    <dbReference type="InParanoid" id="A0A0N0PCJ7"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="794"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="894"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1214" mass="137712" checksum="A705CF3FB75DDDFD" modified="2015-12-09" version="1">MECTQRIECTQELCANPQERIFPEQIGFLGICGTKYSIRKGPNKIGRDPETCDIVLNLNSVSRQHAVINILNSKEYMIMDLGSANKTKLLEKTLQPYIAHPLKNGDTVQFGQIFGVFRLLEDETDLPMTQALDIPDTPIINKHASKLINFPNTVIPESPDASDKDDSFVAPSQSKNYEVFKSPSQKYIKSFGKTIAIQPIGSKQIDNIYWNSSKKSISIDMNLDESDTDVPCHIKTAEVEENIHEMETQIPSSINDDDLYSAETQLCDKNSLSSNKLILKTNSDTRPEIEMDMFVENKENNNSIYNADTQQLNIVTENETKGKTNSTGNVSNDTEGTSKARLSISDEEILFQEVDMEPLEEDFASQPLLFAETVDDRENLPILNSEKSIEGNIDTENKFVEECENKSEGSTDCDDVDMLLTQKIPYIIQNNPSTSGDTSNRNTSNKNQDIDEDSTDCEDDLFDHNDKVNVSNQNTGSSNSNTLKKSEINTQNENKTSETDNLKVQTSENLNFEDMLTQVVEVVDNQNEVDKLINPNESSFEDLPTQVIPVATTEEKSPFKVPFQSVKSIKRKEMTNNFLNTSIRNPNICDDDEEKFYSATQDVLNDLCTQREINTENLSSKGDKFVKDNQNEEMDVDNELRLTKQKSTSSLSSSDVESTPDKSQKNLTFMITEPPNSQEIVKSITFNSKPLVMESFSDSEDNLSEQSTPILFHKRKRIKNTKLDLAKKFELESLPSRTITRKRKPTAKVENNSTEIKNTFKNILAPKIFGEPDEIVDKEIIEANISRIKNTKNMEEKKKLNQNESTKSAQTKQDLVKSEKVETSAPQINDKSLVNPKDLNSKKSRTDTKPSNNEGKKTKSKKKESINLDSTKQEEIPDTLKTDTTRQGSARIKRKEDNKSKPKKDIIKVCIIKDKGKRTYEEKQDESPEKEVRRSKRQKIKKEIETEMSNTKKEERKRKTRSNKKVQNEVSSHYEIEKSIIYRLSDESRSSSPRSVKSSLKDDVTTNINKSEASSERRSLRRTALKTNHKVLFTAFSHPDIKILYNLLEKLNAVIVTDVNSCTVVVTVELKRTFKLLCAVGLGKPIVGKTWIQARRDANMIVDPWLYLLKDEPRETRFDFELARTLTGKRNFLKGYNITSTPNVEPQANEMKLIVECSGGTWKEGGSQWVCVSTIEDKALWPSLKRRGAIIVNPEFILGGVLRQKIDLKKNILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCK1</accession>
    <name>A0A0N0PCK1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCK1"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PCK1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857469" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="19031" checksum="8C6F1EC588F34A87" modified="2015-12-09" version="1">MAHNMLLILFGALLVLSVGVGAKPSAGGLTANIQNDSHGRCKGNNQRCTPNAEHGEIKPPNAGGCSAFGHSCFGGHGKRSSDNSIMDGSNTGLLERRQLGQEETPPHPGYPRSGYSGLLPAGDDIIPIRAGGAYERDDNNFARDVVKYKLRNIVKNWMENYRRSQSNDDGYYIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCT7</accession>
    <name>A0A0N0PCT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460556">
        <property type="protein sequence ID" value="KPJ13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCT7"/>
    <dbReference type="InParanoid" id="A0A0N0PCT7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="290" mass="33760" checksum="7CE7F64ADBE0F4E7" modified="2015-12-09" version="1">MELFRQRSLRELMEYCREGTKKSIERYKKKAKWYWPELHLYCGVCKLRTGLYIRSAICLVFYIIATVLNIIMVYYIVEGGRFLFSMDMTALEDYLEVNLTDVELERAKKIYTLLLSYLIFWLFEGYNLLALSSEYKQLKGKSKLIIYLPDTTNVEAIDTPTDVNNQIEENIRHNISNHCETCTCNEPMLPNTSEVTATNITSQCTSSNEKEVNIKDVEIIFNQDQLLQHSSSVIETRNTRPSRPTVLELPPYLEEESEMKKDKEILVAVIYDQNQLNICGSPIIESQENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDE0</accession>
    <name>A0A0N0PDE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork head domain-containing protein FD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in development during embryogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDE0"/>
    <dbReference type="FunCoup" id="A0A0N0PDE0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PDE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
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        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="38096" checksum="F8363F673577907F" modified="2015-12-09" version="1">MPHDWRYADLADMMYARRRQNDKQSRRLAIGENAQGGPTAPPGALRPAPTVRASRHAARDVRPASTRRNQNRDDMPRPTRDSYGDQKPPFSYIALTAMAIWSSPERMLPLSEIYRFITDRFPYYRRNTQRWQNSLRHNLSFNDCFVKVPRRPDRPGKGAYWTLHPQAFDMFENGSLLRRRKRFKLHKGEKDSLNAELAALATFNRAFLARQANAPLPSASLSSGMYAPVTICPRPSPEPIEVPDTSALLPACPRPRRAFTIDALLEPEPNRSSPSPPAQPQPPPPRCPLALPPNPYLVAAQRYHAELLAGLQQSCLPPLWTWRDTSQFSHYTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDS8</accession>
    <name>A0A0N0PDS8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Doublesex-and mab-3-related transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDS8"/>
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        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDS8"/>
    <dbReference type="KEGG" id="pmac:106709252"/>
    <dbReference type="InParanoid" id="A0A0N0PDS8"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="186" mass="20776" checksum="499F2C340027FBBB" modified="2015-12-09" version="1">MQNESKTVSESGRKALRTPKCARCRNHGVISCLKGHKRFCRWRDCRCPGCLLVLERQRVMAAQVALRRQQGAGTPRVSEAAALAARKKAYRARLRCMQMSRTYPTPPQPYASMRLLSDPAWNERVRRRKVFADEELTEVPLPEPALPALPPAPAALCSHLLAAILSSLHHPAHDPKYPSLLSPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEQ6</accession>
    <name>A0A0N0PEQ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dysbindin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dysbindin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEQ6"/>
    <dbReference type="FunCoup" id="A0A0N0PEQ6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PEQ6"/>
    <dbReference type="KEGG" id="pmac:106715054"/>
    <dbReference type="InParanoid" id="A0A0N0PEQ6"/>
    <dbReference type="OrthoDB" id="2445127at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007531">
        <property type="entry name" value="Dysbindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294:SF6">
        <property type="entry name" value="DYNAMIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294">
        <property type="entry name" value="DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="251" mass="28885" checksum="9F1D2C470D0E47A6" modified="2015-12-09" version="1">MLGNLKEFISVVQDGLSSHNNLRQTLQEVHKVTNIFKDKQKVANESKVNYGAGGEILEKYQNDWVDIHANAEQNAKAADEVDKLIKELHIITNTRVKSYKDFSQALSQLPAVTASVAQCADGLRNLKILLHDIEEQMVEFEDIMERRKMEKWKLDHHYQLTLYKEKKMAELEEIRSKLAKENSEQNMERERKQLAELQAKRENSAIAFQKDIAKYLSSGSVPSKLPSSPKITLEQIQLEDDKTDLEKFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF41</accession>
    <name>A0A0N0PF41_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Netrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459692">
        <property type="protein sequence ID" value="KPJ20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF41"/>
    <dbReference type="FunCoup" id="A0A0N0PF41">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PF41"/>
    <dbReference type="KEGG" id="pmac:106720669"/>
    <dbReference type="InParanoid" id="A0A0N0PF41"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000098">
        <property type="entry name" value="Netrin-A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857466" evidence="4">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="37650" checksum="7C97130280864D25" modified="2015-12-09" version="1">MPVRAVALLAAAALALAGAPPDPCYEDERPRRCIPDFVNAAFGAPVAASSTCGRRGPESLCDPPGDQPPDSACRVCDAARSDRRHPPAHLTDLNNPHDVTCWRSAALPPAAYDSPPDNVSLTLSLGKKYELTYVSLQFCPRAARPDSVAIYKSADYGVTWQPFQFYSSQCRRVYGRPNKATVTSANEQEARCSDSHRLAGEGSGGARLAFSTLEGRPSAANFDISPVLQDWVTATDVRVVFNRLHMVSEGEEPDGKRQAAPGTQHYAVSDFAVGGRCKCNGHASRCVPARAEDGVTLGAGAGAQQLACDCKHNTAGRDCERCKPFHFDRPWGRATARDANECKGNVMLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF64</accession>
    <name>A0A0N0PF64_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="KQ459670">
        <property type="protein sequence ID" value="KPJ20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF64"/>
    <dbReference type="FunCoup" id="A0A0N0PF64">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PF64"/>
    <dbReference type="KEGG" id="pmac:106716673"/>
    <dbReference type="InParanoid" id="A0A0N0PF64"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12821" checksum="EFBC0E641D359984" modified="2015-12-09" version="1">MSRPVLSTHVLDTTSGSPAVGLFVDLYKQRDESWTLWHSTTTSGDGRVQFPFSQDSMAPGTYKLKFNVEDYFKKNDKATLYPFVEIVFKVSEGAHYHIPLLLSPYGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5Y8</accession>
    <name>A0A0N1I5Y8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5Y8"/>
    <dbReference type="FunCoup" id="A0A0N1I5Y8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1I5Y8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF40">
        <property type="entry name" value="CUTICULAR PROTEIN ANALOGOUS TO PERITROPHINS 1-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="808"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1082" mass="125610" checksum="F0DC05DDC5CA2EDE" modified="2015-12-09" version="1">MKVNVENVTDRVLVLVVSVEVPGARAVRATSLIFAKTSSTTSSPEDTSEAEDDALTETTAEGVDGAEAQNATKKLSGIPQIDYIYDPNLPRELNGYNLSDYPFYEAVPKPETMDFKCDGLHDGFYASVPHKCQVYHHCLFGTRYDFLCANYTAFDQKTFICHFVSEVDCKNSPNYFSRNEALYKAATTAPPPPPPTTTTTSTTTAPPRPQRPPRRRRPNYRYDYYDDEDYYPARDDYDYGYEERGGRTRRPQGRPARPAKRRPYDDYDEKYEPRPRPRDESEDYAEERRPYDRRPGNRPYSERRPYENDDRMTERRPNYKGSRRPGRPRDTEEDLYKSVDEDRPRTVPREQKRNEYRPRDKNRPIDDTGDRAQDEESSRDAPQEERPRSESRYRNEGRTRDDIRPRDEVKPTVDITSLDEMPSGRGDDKRPRDEILPRDEVRPRDEIRPRDEIRPRDETRNRDETRSRDVRPRDDMRSREDKRPRDETRYRDDIRPRDERRPLREDAGYEDGKRDSIKPRDRYQPTEGRRLYNRDERPYRREERPAYTKPEKNNESEDKAQEDKRQVPSAPEGQPLVKPNGHGIFSQPRMPPKIKRPVPATEKEKYGYVPIATTKPPPKIDDEYYDDYEDEVSKPSSSGKSSTIQQRPKPEPVVKEKFKPTRSYLTAPGNQKVPNPKRVEDYDDYEYDQPAKKPSYYQRNRDERLAKPNTSDDDYYYEEEKHASTDEPKVKEEDMVIKIKEVRPSNVRVVKRPFLPSRGGSPYLPRGLQPVAGKDLNMPPNTTPKPTTTTTTTTTTTTTTSTPPPTTTPTTTEATTTTTEKVTTTLGTEKPTHEENYKPEEEYEYYDEEDIEYEGHDKKQQEIKETTTSEVIVTKPTTTTSTEATTPADKAKVLATKVLRVFNDNYEAIRSKLQSTLSPGDYLKPYLSASEPIDKDLRYKSPQLKPEISKPYTATGKPLRVPEDFSIKQNLADSIENDYDVALNEALASIPPKVRIPSGFVVSPARDYSFTRYRNNFNTEPQFAASELSSLQTRKRPQVQGVSIRTPTTFYLQPQRVSYHDDGLTRPPRQLVYRQHPTSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I778</accession>
    <name>A0A0N1I778_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I778"/>
    <dbReference type="STRING" id="76193.A0A0N1I778"/>
    <dbReference type="InParanoid" id="A0A0N1I778"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="25951" checksum="058F5E0FC8FB4321" modified="2015-12-09" version="1">MATCGEFVEGWLVAQVLGEGSYGEVRLLVHARSGACVALKAVRSGAAGAGGAAGAREAALHRVLRHPHVLRCMGERLYADKHYLFLEYAQGGELFDRIEPDAGMAPAAARRYWRQLLAGLRYLHSRGVAHRDIKPENLLLDAHDNLKISDFGMATVFRRASPKVTVPKLRPARPRYRAISPASQERDAGTRALILRALIYFTLPILRKPWPEVHGDRKPSYRRCRRVLALLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9D0</accession>
    <name>A0A0N1I9D0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460594">
        <property type="protein sequence ID" value="KPJ13917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9D0"/>
    <dbReference type="FunCoup" id="A0A0N1I9D0">
        <property type="interactions" value="1748"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I9D0"/>
    <dbReference type="InParanoid" id="A0A0N1I9D0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="24000" checksum="CE44ED5357FB4EC5" modified="2015-12-09" version="1">MAKTYDCLFKLLLIGDSGVGKTSILFRFSEDAFNISFISTIGIDFKIRTIDLDGKKVKLQIWDTAGQERFRTITTAYYRGSMGIMLVYDVTNEKSFENIKNWIRNIEENASADVEKMILGNKCDLDAKRQVSKERGEQLAIDYQIKFVETSAKDSLNVEYAFYTLARDIKAKMEKKQEASNPPGARSGAHVLRASDQQRKPPSWLSRCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICD1</accession>
    <name>A0A0N1ICD1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_01978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459910">
        <property type="protein sequence ID" value="KPJ19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICD1"/>
    <dbReference type="STRING" id="76193.A0A0N1ICD1"/>
    <dbReference type="InParanoid" id="A0A0N1ICD1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="677" mass="79730" checksum="EFD2248E9D1BDFA2" modified="2015-12-09" version="1">MVRIPDYETVAMSYILVALKMCFGLDGDYEVQISNVVDKINNKEGHLKSYKIGMYTESTERLFSFDEWTSFLQFRKILICQYYLPMARHYNLEVDDYVLMEHLEERKKRPIKLRDEVTMDILNKIPYQNNINVIPKNEFLPSLTPMSTYTDVLLNIVPNDEIRLLLGEDFTQYNLKYAIEDNKLIDDVENERNIITGIDESNIKVEPELDRNIDVKRSDTSMVYVRNCENKNWLKTKPPTLEHIKQINEDESIDSEDHGYESSMNETQVKTEEFIKEEDTKLEYFEEEQEGVNIFDDDFDFMVKDEKSITDEQPNFNMEELNCSMGQLNTLDESEFNSDIDVDDNNFDKEAIINELISLALKKYKIKLPREYVPRPRKRKADNIETGERLPKKPRIKTGDVKQKINDMIGAYYSHVEIDILNKVTERVKDNFERQENNQNVNISENSTMNDIANNHEQINEADYNLVNTTENMEENNSIDNLNGTNIDENQDFEANLNKEDPDFDAKTHDISQLYVKLNDNVEIDESLVINEDPIIDEIIISKIEKLSTKVTTNNIDEIKVNSVRKNKISFYLSDDSCDEEIKQQENNERNKDFFPLLINDPTQMNEFNYWLRFYKNDCISRYTHAHFKFDSEIKEQFPASFYFVLNECANIICCSTYNLYKDMQNLEKMIVGKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF83</accession>
    <name>A0A0N1IF83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IF83"/>
    <dbReference type="STRING" id="76193.A0A0N1IF83"/>
    <dbReference type="InParanoid" id="A0A0N1IF83"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="41898" checksum="FB12635E9435C89E" modified="2015-12-09" version="1">MLRPESPLADHRSLLPRRLLPVKAQIAPADKRKNRRSLELNPPNEHAPYDYPKLLISKTTDSLNTECPRKIIHKQDSTDSLKRALLTKDDKKAAKEADKKSVTKQDSSESLKKALLSRQESNDSAKRKESDPKWTQRQEDLKRTVEVKRGSDKKGLLETDSDDSCKRIYERRSGCARPTLPPVAEKSVPSQKSPNGSPKTPGVAAVAEGVVKWGSGLLSPKEEPRLRPARSWYGYGTLPTDGDKMGAGATGPGGRRALELLLSSGLKSLARPARPVRRAASRDSVLSQPQPLLEGLRKCSTVLALSERERVGEPMRAHNRLRAPSVCSRCSSLLSLAGAGGSRGGGFDGGGDALDSSPLLGQPGRCAVPPHATPCSHIPSHCLKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFQ1</accession>
    <name>A0A0N1IFQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460210">
        <property type="protein sequence ID" value="KPJ16579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFQ1"/>
    <dbReference type="InParanoid" id="A0A0N1IFQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="14968" checksum="265DC0616C2A1A24" modified="2015-12-09" version="1">MTTIILASLPYSCTLSLPSGDPAPGRSPGPPINFEHDVLQDKENLKYIDDELETSLGVPVEDAAIYDETTTNDIETTTKSEVVSVSEMAIGDTCAFARIPSDSADIVTLSETDSDINLTVSHAVFDADELVRGVIYDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG19</accession>
    <name>A0A0N1IG19_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG19"/>
    <dbReference type="STRING" id="76193.A0A0N1IG19"/>
    <dbReference type="KEGG" id="pmac:106707741"/>
    <dbReference type="InParanoid" id="A0A0N1IG19"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="496" mass="54617" checksum="6DF3FD6A40CD938A" modified="2015-12-09" version="1">MKPFIKQAFVVSGAALNIVGHGCAHGFPAVLFAQLKADGGPVTLTDHDTSWIASVVGVMGIVGNFISPILMTKFGRQKAHLISTVPALLGWIVFVIGNTVSAFILARLLHGLALGLRTPLAAILVAEYTEPKYRGAFLGTFAISLGLGILLSHVWGAHLTWKITAVVCSMFPLIAMTIISLSPESSSWLVSKGKFDEARKAFVWVRGNGEAEKQELEALIKAQEREQTLEHNTIKVIKKFRWKHIMRSIINTLKTVLKIFKKKEFYKPSIIAICMLIVFEFGGAHMVPAYGNLILQAVLDKKDLSDVTWQFTVIDLLRTICALLAIFLLKTFRRRTILFSSGVMTVLSLSAVSIFMYLRNAGVFAEGWMLDVVPMGLMILYTLSFCLGLVPLNWVICGEVFPLAYRSLGSTLSTSFLTPSFVVSMKTAPHLYTSIGVEGAFLVYSATLTVCLLIMYALLPETKDRTLQDIEESFKGKKSGDVETQLSLIVKENVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II58</accession>
    <name>A0A0N1II58_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Frizzled-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II58"/>
    <dbReference type="STRING" id="76193.A0A0N1II58"/>
    <dbReference type="InParanoid" id="A0A0N1II58"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF23">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="31959" checksum="EED87199B5493F80" modified="2015-12-09" version="1">MRIKRLSQCVWSHSCQWVVVAGAWRASVLRPPAPGVPGTGGAGASRGDRHSSLLQLAAWGVPAALAAAVLVTRDVDADELTGTCFVGNQSSKSLLALVIIPEAICLLLGCLFLASGLRTVLRRPAPVPAPAALLNAPPQPHTDQSLLRLGAFAALYAVPSTCILATWIYEYTWRDDWLAAPEPSTEPSTQPRPAFWVFLFRIFATQILGVMVAVWIATPRLKALWRRISGPTKPTLAKCPAGPTPTPLTLQCYSTHSHSLPRHTHKYATYRPPQHQSYRKPRHYHYSAGETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IID3</accession>
    <name>A0A0N1IID3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IID3"/>
    <dbReference type="InParanoid" id="A0A0N1IID3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005732954" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="187"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="48094" checksum="D90CEAAFD0822A72" modified="2015-12-09" version="1">MRSLFVLLFCAGYVTCQLWRKGVVHYAINKKDYDVHSQDEIITTLSQLQNEICVKFFYTPNNYTADEKDKILFINNPDKRKNCPPIVYNFTGSVIDMPIGYKCINRKDIARIVMDMLRASVEQTVSTINSYDLVKKFQERDADSTHPTLLSPPDRNYINAHYHVECGSQAQRSVASRRLGDTTDPLQLTPDNLEFYKDKIWPLAIVMYGVDEKLRTKPDYNLLKYAMTTIELASCVVFQEIVTSDGVLTPKNYLWFTNDGEEVPQLGFREGKQTINLETMVHGAPGHTAHVLVNLMRALGVPMMSNRFDRDNYVTIDWRKIQKGKEHHFERAPASAWVATPYDFESVTHAPANYMCGDCDLGGQSVKPLQDHLWQRTLSMGHATQPSDSDGKLLDLLYRDQCRERIISDNLEVMKKTADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-03-27" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKP6</accession>
    <name>A0A0N1IKP6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-tubulin complex component 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01017515">
        <property type="protein sequence ID" value="KPJ21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKP6"/>
    <dbReference type="STRING" id="76193.A0A0N1IKP6"/>
    <dbReference type="InParanoid" id="A0A0N1IKP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="147" mass="17093" checksum="4B97A84AB7AC1C23" modified="2015-12-09" version="1">MIEDNELVNKEELPVDYSADYWEKRYSIQRERVPKFLEKYTDIILRTGKYLNVISQCGIQKRVKKNFSDIITTEHMLSLNKKDLSICLKNYNVEDIKSPQDEEMEDEDVKPEPSKYDVVPSLPQTAEIVVQKGASTWIEISSGSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INL4</accession>
    <name>A0A0N1INL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461178">
        <property type="protein sequence ID" value="KPJ07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INL4"/>
    <dbReference type="STRING" id="76193.A0A0N1INL4"/>
    <dbReference type="InParanoid" id="A0A0N1INL4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="29507" checksum="2AD6CCF71CDF2604" modified="2015-12-09" version="1">MERYTNITTAYQLERNMKDSPRVPGSPQRRPTAPSAEGVVAEAGPAASPRGGQSADGAVVVCYCVPTAPSQAEKVEHRWVLVSIPGAPIGAGGASHNRPPPRRAGELASRRYSAVGHPNPLVVGAATYNPIALGKFRRDYRRPRHVLDFQDDAITIAQAKLKHHKQITRRSRCRLRQLFSRYGLIAGRFSPINSRSVAGVSSATSSPSANAFRSGSNVNCINNNNQIIATDQAEVRPSRAPLNRNAKRVMSDSPSRGPLSGALAPSHSMERPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INZ6</accession>
    <name>A0A0N1INZ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460708">
        <property type="protein sequence ID" value="KPJ12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INZ6"/>
    <dbReference type="InParanoid" id="A0A0N1INZ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="372" mass="43419" checksum="3EB3874AD9D4B122" modified="2015-12-09" version="1">MAEDDGEIEFLDEDADIVQQCVHTDEDPPPLKAPIPFLVERSPVEKPRKKRKTEEDSDYEPSKDAPSKYKKRKTQKIPRSSIKSQKYEYFAQSAPIKYKVKEYGPRKMKKSQIKTEEIPRTQLDIRIPDYDDPLCMPVRAVKKDGSDTTKLKIWNNLCLEHFKKSDTVLRPDNGETVSSKRTVLLKNIFNKFTGRQETSMWTKTMVTNNKGVTKSDVVQSVLPKYREKKVLNYNLIDTKRRKSYHHVDEVILTKEDQKDGEQLIVYKPRETISLVYKMFEKTENSEGKEEDEEQKKYMKEVASCRMCAPCFQVSWRGSRKEDKKIRCQICSMVCASVQRLLAHLKSHSAHDMNKYKRLVSRALAKVSTETYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP76</accession>
    <name>A0A0N1IP76_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP76"/>
    <dbReference type="STRING" id="76193.A0A0N1IP76"/>
    <dbReference type="InParanoid" id="A0A0N1IP76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="31331" checksum="04B0E420BE79D1C8" modified="2015-12-09" version="1">MEDDTAWSEEKAFCLIDAYRVREILWNPQNENYFKKNLKQDAWSEIAKFMTMTVEKCNRKIVSLLSSYRREKLKEKKSKGTGKVASETYISRWFAYDALKFLDDRNTPRKRNNTESLHRSDLENTADQNVFTPPVLPNECTPKSAKQTRRDDNVLSDVMGILKTTANKLDNSIGIPDTTKSFASFIGAKMTSYSPQTRTSVEHAIFEIIMKADRGYYESWRHQNNRPSISAGPPSGTNEAGPYGYTTARNEDTTDYPTIQPPLSACSRCDRCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPQ1</accession>
    <name>A0A0N1IPQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPQ1"/>
    <dbReference type="STRING" id="76193.A0A0N1IPQ1"/>
    <dbReference type="InParanoid" id="A0A0N1IPQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061138">
        <property type="term" value="P:morphogenesis of a branching epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042345">
        <property type="entry name" value="Btbd7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="271" mass="29993" checksum="36EE63FBB70C8BF7" modified="2015-12-09" version="1">MSRLLCCLRARRQDMGAALYPAQPQEGEACDGAAEHVAPPTMADVIRERKKKAGGAALGTLRRRLAAATRRPRDSRPDRGELAKKTVELCHKWSTWYFTTYATLRRDAVAGCEHARFIRSVVSSWRLAEVFVLCEQLEAGAALRDLVTQAELAREPAPALHQDLAQAYRDRWMCDVELVGAGWSVSAHRAILAARCSYFRELLQRYPGVCRVPLEGAAAGLCREEMEAVVGALYAGPSCVRRPPCDLCNKSDLDIISGENTACECSMYYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPU0</accession>
    <name>A0A0N1IPU0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase family member 9, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460253">
        <property type="protein sequence ID" value="KPJ16364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPU0"/>
    <dbReference type="FunCoup" id="A0A0N1IPU0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPU0"/>
    <dbReference type="InParanoid" id="A0A0N1IPU0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="8">
        <location>
            <begin position="403"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="533" mass="60129" checksum="4B5767353C264953" modified="2015-12-09" version="1">MNIARTICTIRYQSINKRFSRKITIGNRYESSSTQPQVKDEKYNFEDLKVLERVERRKAKIPPFMKNVFVSIFDRDLLAFPEILNKDESEALDQRVAALDRVFSDPDKTIEDRKNALKGTKMYAAPVALTDNGLAVNHTESLRYLEAISTDLKLSQQISDHWVGLNALKIGLAEDMYQKVINDLISGENTIALCIRERVAERISQADFRTTAEVDERGVWRISGEKICLQSSEYYLVLSIVDTTRLKMFLVHPGAYGVSHNGTYVTFMKTPALPLDMATEENLAKTLGVSRLYTASLCRSSLLQAMKIITEYITPRTFSGKPMSEVSTIRSVIGEALLNIYASESAEYFTAGLLDGYMDPDAELEIAMCRSGDTNFNLLGCSGIMSERDDPKLNLYLAEHLHPSLRVPSEQLEYCVLRMKFSCETLLSRHGMDVTNAFTELSRMAEAGSEILAMTAVLARASRSYCIGLRNAEVEMKLAACFVESSKERVKKLILEVNDGEYLNLDKFKTTFGRKVLETKSVLVEKPTARVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQH9</accession>
    <name>A0A0N1IQH9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulin-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01013035">
        <property type="protein sequence ID" value="KPJ20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQH9"/>
    <dbReference type="InParanoid" id="A0A0N1IQH9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20235">
        <property type="entry name" value="PFM_spherulin-2a-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="13674" checksum="E47D7DC917A78DFD" modified="2015-12-09" version="1">MFGKATGTSGISFTSSWGESEERTESVTVQASSSVETELQPGQAATAVLSASKGSLEVEVLYLATLRGNVVVNFKSAYKGHHFFGPSIDSVMNSGDLDNEVIIKEIINIGFYTEANLKVYDKVSGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFD9</accession>
    <name>A0A0N1PFD9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFD9"/>
    <dbReference type="InParanoid" id="A0A0N1PFD9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131817" checksum="B96C6E37A9C7E6ED" modified="2015-12-09" version="1">MENLNENKTNRLFIYPQVPRTNFLRRTRPTTVPITTDSNTASPDNVETTTSKYTRRGNSRFKSRKDAAENVPQIEKTRESNDTDVRTRRPFSNSDRPTPRNFAARRRFGGANSTNRTASVSSTTAASVSRRPFRVASRRRPAVTTKLTTTTTTTTQATTTTNILDSDEYLQDIEEADSIEDPTITTRSGPKKNPKTQRRPLVNLKEDDQNPSATNEEEKKRQSKKYSSTFKQNQLDEALKLKNQDAFDEDVDATTEGKFTESFSAETAVALAAHKLLEAPVPIIPDYEYDIKPTRSAPTRNTQKFKYTTTEYTPEITKTPSYPLSYSTTPNYSTETQDYVQTSTGLYSGDLLDTVLPSTGGYRGSKPTGFTAPTIINPGLSGVSRNLGPSTVRYLSTTEENIPTQEINPTAGRYTDTSEKYSKSSSRLPDLTNVYNYSSISYNFTPRDKYINTEESLQTVTPTGRSRGRRPSTTISGLEQYTVTSQTLPPTNDFGISKKYSESSRPTTSANKYLDERYTGISEDPFETSKYLDTSDKYTDSYSTPGPSTIDYLDSNRYTGTSQNLNPRFTVGEKYTNPSTPTYLTEDITRVSQEPTPTRGYTETTDYSEVPANTRIPSRFTNRGGSYTTIQNLNPTTTYSDTTDRYSSISRRRKPSTTTVSDNDKYTTVTLQTTNPTTTNERYTEASRRRRPSTNTYTETDKYTTGTVQNVNPTEVVISTTEKPVQSRRRRPSTNSYTNSEQYTTETTTAFRFTGTSERYTSVPRRTRPSTSRYFDTVTEEASSEFQTAGPTTGFTGINDRLTEASPRLRPTTDSYIDTSDKSTDTPQIETYTVNNKKYSDISRNRSPSTSSYLESTEKSPLSSSTELSEDEVSTGRYLNPNGQYTGFIQDVNPSTVKYVSTEEKSQNVSPSSVQYPSTTGKYVSGPVDDFGFSTAGYSQSQDPSYFTREYLLASPVTKTYDDEYQYLSPVTTTQPTTTTRKLGRKKTIFRRISSTARPSSTTTTTTTTERPRRVVSRKPFEKIRKVQKVKVLKVPKKEQEKQLVEEEKPVNEVQITQRQQVQRVPVKNVESPKPNRVRKPITFDYYDDSEEKVAQKYEEGTKVILHSKGTIECLDIGNFPHPSSCKKFISCARMESGALLGWEYVCPKGLSFDPVGGICNWSAGLGCNEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH44</accession>
    <name>A0A0N1PH44_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_03444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH44"/>
    <dbReference type="FunCoup" id="A0A0N1PH44">
        <property type="interactions" value="1781"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH44"/>
    <dbReference type="InParanoid" id="A0A0N1PH44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000121">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ09840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="563" mass="63077" checksum="392A7F2DA3E6413D" modified="2015-12-09" version="1">MSAPAHDPGPEQFQQFPPNRIIVIHPGSLYVRIGRASDLLPVKQLHCIARKRQPGGKIYRDLFVPPSIPKTKELIEELEECRLQISHTLQSCMQSNGSRRYATPPQQIAAFNRRSLPETVNDGEPWPQVECDIVVGDLVLDVDPELEYNVHFPYKRGDFNIHSEIGGSVSSVLNDLYTIWSSIIEYKLGIPLIELVKYRCVLLIPDIYSRSHLKCLMSLLLKDLGFGHCFLVQESVGATFGAGIGSACVVDIGDQKTAISCVEDGISHKNTRLRMDYGAGDVCQTLSWMFHKSAFPYKNWNENTPRDVVLMRNLYQDFCHVNLDVCGPQEKTFLVDHPGDVINKYTLQVGDECIISPLSFFYTDLLKITGPKSTKIQSRQPSDPEDPFDAEFLRETGRKRETVDPTANENQQFESVNENQPTGNADEDIVVDTLDGGPGDIVSLAPGQVLGLDAAILQSIDRCSSEELKRKMYSSILIVGGGVKVHGLNLWLQNRLALQIPYAYKTEQLEIVTSPKDIDPASTVWKGAAVMSCLESAIELWINQSEWTKFGLKILRERAPFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHC5</accession>
    <name>A0A0N1PHC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kv channel-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460301">
        <property type="protein sequence ID" value="KPJ16130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHC5"/>
    <dbReference type="FunCoup" id="A0A0N1PHC5">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHC5"/>
    <dbReference type="InParanoid" id="A0A0N1PHC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF186">
        <property type="entry name" value="NEUROCALCIN HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="27053" checksum="7D1BB2E2D3CF2815" modified="2015-12-09" version="1">MATPPESPVEEHAYELEPSRTPKPIPVALEELCRQTKFSKQEIRVMYRGFKTECPEGVVHEESFKDIYAKFFPHGNSALYAHYVFKAFDVNCSGAISFRELLVTLSTLLRGSVYERLRWAFRLYDVDGDGAITRQELAEVVVAVHELLGRRAPPGSPAARLDDAKANEQVDRVFRKLDLNQDSMINPNEVIRVMLVDRVFRKLDLNQDGVITIEEFLESCLKDDVITRSLQMFDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI39</accession>
    <name>A0A0N1PI39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Growth/differentiation factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459933">
        <property type="protein sequence ID" value="KPJ19280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI39"/>
    <dbReference type="STRING" id="76193.A0A0N1PI39"/>
    <dbReference type="InParanoid" id="A0A0N1PI39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000006">
        <property type="entry name" value="growth/differentiation factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF262">
        <property type="entry name" value="LD29161P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="179"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="291" mass="33301" checksum="76C2DC07F9A68123" modified="2015-12-09" version="1">MYERLYFCGKCSALSGGLELLCFRNTRRHSHFKGLKVINFRFTSKVLQNEVDEAFLNIHVQELEQRLNVTLGPEEFFSIGLQVNRVTRNSQGSKASVPYMETSIKMSRKELKIGRWVKLNVTNMVAEFFRLPRENLAIVVRVQDSKNRVSLVVPHPSSESNNALMPYIEVSLRDNSHKRTRRTIGMDCTENSKEVRCCRYPLSVNFEEFGWDWIIAPKQYDANYCSGECPYSFLQKYPHTHLVHLVTPQGSGGPCCAPRKMSSISMLYFDDDLNIIYGTIPGMVVESCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIP8</accession>
    <name>A0A0N1PIP8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_00850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01027741">
        <property type="protein sequence ID" value="KPJ21167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIP8"/>
    <dbReference type="STRING" id="76193.A0A0N1PIP8"/>
    <dbReference type="KEGG" id="pmac:106707434"/>
    <dbReference type="InParanoid" id="A0A0N1PIP8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ21167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="31772" checksum="F0206EA355B5D798" modified="2015-12-09" version="1">MANQDKPNSATSTANPSASQALQTTEDENQKSCWVCFATESDDRLAAWVQPCKCIGTTKWVCEMTLEAADAGDSGGEEKGESGAGDGDDDDDDEEGEAEDMEQFQASGLLDEVDPSTELRPRRESKPAGAGAGARSGAGARSGGRAEGEGDDIVRTRTYDLHITYDKYYQTPRLWLIGYDEERRLLSVEQMYEDVSQDHAKKTVTMEAHPHLSGPTMASVHPCRGNISRKVLCPQCKAEYIVVFPSMGTFVALLDALEEITHKISPFIAGGVLLGSIYWIAITYGAVTVMQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJW3</accession>
    <name>A0A0N1PJW3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator ATRX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_00355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01038224">
        <property type="protein sequence ID" value="KPJ21336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJW3"/>
    <dbReference type="STRING" id="76193.A0A0N1PJW3"/>
    <dbReference type="InParanoid" id="A0A0N1PJW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ21336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="142" mass="16403" checksum="FC0EB29BC4FF247C" modified="2015-12-09" version="1">MSMGSGRFAISANSCGRLLGTMEEKIYERQVTKQAISKRVIDEQQIDRHYAENDLAELYKFLPRPPAPRPLPPLPKDRLFAELLREHDAQVHKQTNKYNYSLKQGEELSFADFFAILIAVCSFLFLTDSNIVCSFKYFFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PKG3</accession>
    <name>A0A0N1PKG3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 48 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Regulatory component of the Usp12-46 deubiquitylase complex. activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation. This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes. Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Catalytic component of the Usp12-46 deubiquitylase complex consisting of Usp12-46, Wdr20 and Uaf1; regulatory subunit that, together wtih Wdr20, stabilizes Usp12-46. The Usp12-46 deubiquitylase complex associates with arr/arrow; the interaction leads to deubiquitination and stabilization of arr/arrow.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459680">
        <property type="protein sequence ID" value="KPJ20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PKG3"/>
    <dbReference type="FunCoup" id="A0A0N1PKG3">
        <property type="interactions" value="2607"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PKG3"/>
    <dbReference type="KEGG" id="pmac:106720352"/>
    <dbReference type="InParanoid" id="A0A0N1PKG3"/>
    <dbReference type="OMA" id="IIRVWHT"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000543">
        <property type="entry name" value="WD repeat-containing protein 48 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000984">
        <property type="entry name" value="WD repeat-containing protein 48 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="647" mass="72590" checksum="9790A664491F9E4A" modified="2015-12-09" version="1">MSSIMRKKTQVSFVIRDEEERRHKNGVSSLQLDPIQGRLYSAGRDGIIRVWHTGTGTQDRYIQSMEHHTDWVNDIVLCCGGKNLISASSDTTVKVWNAPKGFCMSTLRTHKDYVRTLAYAKDKEQVASAGLDRAIFLWDVNTLTALTASNNTVTTSSLVGNKESIYSLAMNPPGTILVSGSTEKVLRVWDPRNCSRLMKLKGHADNVKALVVSRDGLQCVSGSSDGTIKLWSLSQQRCVSTIRVHSEAVWALLATETFSHIISGGRDRLVIITELKNPDNFMIVCEETAPILKMCFTADQLGVWVSTSDSDIRCWKLPPHNSLSDMYNQNSYNTNNVYQTQPMYHIPGGRAIKHYTVLNDKRHILTKDTANHVMLYDVLKASKLEDLGEIDYDEEVKKRFKMVYVPNWFNVDLKTGMLTIHLGQDETDCLSAWVSAKEAGLTIENDQKVNFGALLLQALLEHWNHPNRANEGGQKVMGNSFFSVPLHTPLIFSEVGGRTLYRLQVGDAGGETESNLLMETVPSWVVDVAVEMAAPKLNKLPFYLLSHSSCQSKQDRQKKDRLVANDFIQCRKVAEHVVEKIIGGGDVNGASSSKPTNEDSGNDPPEERVELLCCDQVLDPNMDLRTVRHFIWKSNVEFTLHYRVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLR1</accession>
    <name>A0A194QLR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low affinity cationic amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLR1"/>
    <dbReference type="STRING" id="76193.A0A194QLR1"/>
    <dbReference type="InParanoid" id="A0A194QLR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="347"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="885" mass="97382" checksum="306216CE15C92C20" modified="2016-10-05" version="1">MAGGKWSALGRALARKRVFEPDQLEVSNLRRCLTIWDLTALGVGSTLGVGVYVLVGSVALHFAGPSIILSFLIAAVASFFAGMCYAEFGSRVPKAGSAYIYTYVAVGEFVAFIIGWNMILEGVFGTASVARGLSLYLDSMTNKSMSGWLLQAAPIYSPQFSPYFDLFSFLVVLVLGAVLSLGARESSAVNKVLAASNMLVILFIVIAGAFKADSRNWSIPGSEVPEGHGSGGFFPYGAGGTLRGAAVCFYGFVGFDTINSTGAGAAACDPDSNPDGTEHCVCGLRQRVCRHHYDGTLLPAVCICLSTALVGSYVAEPLVPILVLHGVGLALMVVIIMQPQANEDLPFKTPLVPVVPCLSIYANIHLMILINVQTWIRVIIWIAIGIPVYFICTCYYKKMGRRNSSEDKPPTQLNKNGGPPVKIIIETPTPPDTIKISSSRGGDLSISSTIKSSVVGTPVEQKVVRNYIPFVTEEIIVKQAIVEDNDEKEAKIIDLLDQVLQAEEDSYEEIITLQEPQGEDSYEEIITLQEPQSEEKDNDTAMTVDVHRKSLSELSDAGSDASLGNQVLSKYDVIALVHREDLPKLTEEEEKNERDDIDQNDDYEYITEFNESETNSRTDESGYSDTLDKNTFSESVEDNRIQAPVIPVPPPMDENLFSNPTFKKSYTISSRPSKARLFPEPPIENPRLSIQSNGSIDDAPMVFGSDKQMNFMSKLNTIFQTKMSSFNNGEELRKRSHSAGNLAENAEYSLRQERPPIYYDLKKEIEARNLKEKEEPVKTAQGLVEDRKEPNKNVSDSDDDEDMSLSREDLKSKLESIFAAGGPRLVKPRVMESNPPTPEEPYSWSAENISRIPKVEKNDTLKRQKAKFNEVLNSIRLSINKSDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM83</accession>
    <name>A0A194QM83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SET and MYND domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM83"/>
    <dbReference type="FunCoup" id="A0A194QM83">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QM83"/>
    <dbReference type="KEGG" id="pmac:106719729"/>
    <dbReference type="InParanoid" id="A0A194QM83"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="242"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="683" mass="78206" checksum="139DB06D3D9DBC67" modified="2016-10-05" version="1">MSDKEGFFIKFHEKINHSLDDVSKNNFANLESNSKRVSYLCSLPAVKSYDLTCDISKCSTDGEIFEKKDLEKAHQLKEEGNKAVQKGDWAKALEFYSQAMLFVPHKDTDELSILYANRSAALSHLEQYEDTLSDIKRCLSLAYPRHLRYKVYERRARTLLIVKRHQEAITAFQDTITALDEANNLNKEKRQKMRTDAKLMLEILNKGITLAGNPKDPEPLRKTPPKPKLPGKNNPQYPAASDAIQIDYDEAKGRYATAARDIQAGETLLIEKPFSGVLLGEYSKTHCQNCFIKCPVPIPCPRCPNVIFCSEKCSDAAQKTYHSYECQILPLLWKSGCSITCHIALRMITQHKKDYFNEIISNFEEKPSGIYKTGDYKNIYHLVAHEDKRTKQDFLHRTQMTAFLLKLLEMSGYFDNKPREKSIDTNELKTLGIDEKYKDDVALIGGLILKNLQVLQFNAHEVFELQCPKPRVGNNVIKHTGKSVFLAGAVFPTLALFNHSCDPGVVRYFCGPYIVVRAVKNIKKGEEVAENYGPIFTTVPKEKRQADLKEQYWFDCTCVPCQQNWPRYDDMTENYMRFKCDSDHPCPNVVPVPYDCNEFMVKCGLCNQYTNILKGLKSLQDTDMMYKLGRGAMEEGKYGEAIKKFIDMLKLYDSTLAPPYKSYYDCVQDLRRSMLAMGNYSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMN4</accession>
    <name>A0A194QMN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMN4"/>
    <dbReference type="InParanoid" id="A0A194QMN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="204" mass="23597" checksum="60078A3681AED8FA" modified="2016-10-05" version="1">MFTKKSSSRRVDLPDTYSPKPEYLPDTALAAIVSYKKQKDVNDFVSFVLDALERNAHWLNNLVDKQNSFRCAFMIGSGPNRFQIKQIIYPQQDAELKLEVDCRDSDDYDKVAIAALLKLTSADIDRVLKYTKTRFFENTLMREELYKGKLIGISYAVLRPIYDDQFRLSERIVIGNTLRYGSPLKRRLVDKSVTRNVKKAKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMN7</accession>
    <name>A0A194QMN7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMN7"/>
    <dbReference type="FunCoup" id="A0A194QMN7">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMN7"/>
    <dbReference type="KEGG" id="pmac:106720210"/>
    <dbReference type="InParanoid" id="A0A194QMN7"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="397" mass="45093" checksum="094AE29DDC6F5EF0" modified="2016-10-05" version="1">MTSSSQDYIFEPFKVTEVKFRGSEVPRPRSGHRIVCDDINIYCFGGYNPVLPLNSIQRVDPTWSPQRPLFKELWSYCIVTRRWTQHKVVQNMPEELASNAMCMNGRYLMIFGGTGAPFGNKCSNDVITWRTNPGDAKLEILNVTGIRPPGQYGQSILCHNGYFYTIGGTNGFAYNCDIYRLDLRTMNWEQVYVGNGQDGEPVGRYRHEIARVGNKLYIIGGGTGEYAFELMEIPVYDLDTDTWSFLSPKADDTLRETLAPLARKCHSAVQVNTEAGPQVFVVGGSDGQSMFDDIWRLNIKEMQWNLMQKTVLPHPLHFHSSTVTSYGCMYVFGGIEPKDEATSRNNTLYKVWVCIPKLSEICWEALLNFQPNLDQVDKRTLLNIGIPAHFVDRVHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMR8</accession>
    <name>A0A194QMR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMR8"/>
    <dbReference type="InParanoid" id="A0A194QMR8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="11560" checksum="BF3C2990A8AC7708" modified="2016-10-05" version="1">MLKFLTHKLRTHSLNEENVSEKVEERDSGTESDDEAERAECADTGECCYCLLRAAPAGTRRPAHTLSNDTRAFATIQVSTGTLVKQSGVSIHWCTHDCDLLESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMU3</accession>
    <name>A0A194QMU3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMU3"/>
    <dbReference type="FunCoup" id="A0A194QMU3">
        <property type="interactions" value="2198"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMU3"/>
    <dbReference type="InParanoid" id="A0A194QMU3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRE1-like coiled-coil containing" evidence="11">
        <location>
            <begin position="69"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="BRE1A/B-like" evidence="10">
        <location>
            <begin position="532"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger C3HC4 RING-type" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="377"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ06280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1139" mass="130005" checksum="6F863487D258F759" modified="2016-10-05" version="1">MSKRSAEDGGNGTSQPPIKKVHFEPHLIGPVSTLEEMDIKVLQFQNKKLAQRIEQRHRCEAELRARIEQLEKRQTQDDAVLCVVNRYWNLLNEDIRVLLQRFDAETADESENKNENEATTSFLMQLSTWDKEELDAQLANRVQVSKRAVAKVLQAFDRLQQRNDKIWRAIKGEGEEGAPAPSLDEVVRATNEEVTAENRRLQGICTTLQENHHAMTLRVAQLQDAVNSRDTENAELKNQIDDLQYELMKVRSRNDKLENHLAEAIEKLKSYHQSGASASSSSSASTGGTPLTAAAAAKLEDVAAELEEQRELANNRLAELDRLHRQHRDTLKEVEKLKMDAFDRLQQRNDKIWRAIKGEGEEGAPAPSLDEVVRATNEEVTAENRRLQGICTTLQENHHAMTLRVAQLQDAVNSRDTENAELKNQIDDLQYELMKVRSRNDKLENHLAEAIEKLKSYHQSGASASSSSSASTGGTPLTAAAAAKLEDVAAELEEQRELANNRLAELDRLHRQHRDTLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQMKTALDETRMQLQNAKNLHMRQIEMMESEELARQKALRAEMIQLEDVLGQLRKEYEMLRIEFEQNLAANEQTGPINREMRHLITSLQNHNQQLKGEVSRYKRKYKDTSQELNKLRKETEEAAARGGASTSGEQPDEKPPPVKKEEPDPDERLKHSRSYVRCRHRLVSRPSGALHQGEWESVSESVSDGPRPRMGSKLVGADNGHMYGEEGGMGGVGAVGGVGGVGVDKPASKEQARGKLHEQEQIIKELKQQLKKAVNEQKELKLLLDMYKGVSKEQRDKVQLMAAERKARQELEDHRQKAKMAQESKRERRMADEDALRKIKQLEEQKYELQKQLSCARPNADPLHAFSRPFAGSQEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANSLHKLLREEKQLLHEKVVTRDQQIESMGAVARRLEEKERLLQATLSAVEKELLLRQQAMEMHKRKAIESAQSAADLKLHLGYYALHYYAVQSDDCSAGGLILILFPFPPFSNKEWMGRESEFGGRSDVKRKDAVLTKCFHVFCWDCLRTRYETRQRKCPKCNAAFGANDYHRLYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN60</accession>
    <name>A0A194QN60_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN60"/>
    <dbReference type="STRING" id="76193.A0A194QN60"/>
    <dbReference type="InParanoid" id="A0A194QN60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="214"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="697" mass="77532" checksum="60D5FF233AC53E01" modified="2016-10-05" version="1">MVTTFVLLMEFIGNKNRDVISALYHVPFNIGHMMLPLIAYHYRDYKKFLLVIAIPSAILLCYICLLPESARWLIAVKRTDEAIAILEKEAKISKRQVDIRKEVAAYAKTLTGPNAQKGSLADLFRTPNLRKNILCMSFNWMACSYCFYGVTQYVGHLSGNIFINVAASGSVALLGAFTSIPLMRACARKTVVVLFHFLCAVCLFALMFVPEGTLSVILACTGVVSSFIVFVVVYLYCSELFPTVVRNAAVGFSSMMARVGSMVAPFVINGADIAHWLPPLAFAILPLIACWVTFLLPETKDCELLTTLEEGENFGKNVANKPKYGRRKTLIFAVVMESLTGIVASFLPDFWSFTIIRMFLGISVGGIMVIGFVLLMEYVGIMYRDALSALFHVPFTMGHIALALFGYYIRDYTHLQLAISVVNMVLLFYICFLPESPRWLLAINKSSKAIALMERVAKFNNLPTDEIPTMTELYQMEHKSARMKRGSILDLFRTPNMRRNILIMAFLWLVCSYCFYGVAHYISHLTGDIYTNVIASGSVALCSCFISIPLIRFLRRKTLVIASELASSICLILIAFVPEGTISIVLGCTGVFFTFMVFIVVYLYCSEMFPTVVRNAAIGICSMMARVGSMIAPFIAGLRPFGIWCAPVAFGIFPLISAVLCLFLPETKNCELPMTIEEGEALGRNQNQNVTVAEDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNG1</accession>
    <name>A0A194QNG1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ribonuclease Oy</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_11393</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a guanylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-GMP-RNA + a 5'-end dephospho-uridine-RNA</text>
            <dbReference type="Rhea" id="RHEA:81323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="Rhea" id="RHEA-COMP:19658"/>
            <dbReference type="Rhea" id="RHEA-COMP:19659"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
            <dbReference type="ChEBI" id="CHEBI:231849"/>
            <dbReference type="ChEBI" id="CHEBI:231850"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an adenylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-AMP-RNA + a 5'-end dephospho-uridine-RNA</text>
            <dbReference type="Rhea" id="RHEA:81383"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="Rhea" id="RHEA-COMP:19675"/>
            <dbReference type="Rhea" id="RHEA-COMP:19676"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
            <dbReference type="ChEBI" id="CHEBI:231879"/>
            <dbReference type="ChEBI" id="CHEBI:231881"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81384"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNG1"/>
    <dbReference type="FunCoup" id="A0A194QNG1">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNG1"/>
    <dbReference type="KEGG" id="pmac:106719459"/>
    <dbReference type="InParanoid" id="A0A194QNG1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000001">
        <property type="entry name" value="Ribonuclease T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264503" evidence="18">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="269" mass="31138" checksum="5CCDD6F74D2BCC48" modified="2016-10-05" version="1">MINAVLRTLFIICLGITYVQLREIKTTEPQWDLLIFTQSWPATVCIEWKEHDHTHTCNLPSNKDSWTIHGIWPTKLGTIGPAFCNRTWHFDPEQVRPIEKNLEQLWTNVESGTSTYALWSHEWNKHGTCAAVLEPLNSELKYFSMGLNWSQKFMVHNILQASGIVPSNTNEYSVLDMYNSIKNKLGVNPVIECRKEKSKNYLGEIRICFSKTLDLHDCDGVLNLKAKMYEGKSILTNCDTSQGVLYPHYPSNTYVNLYKLAMWLQWFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP64</accession>
    <name>A0A194QP64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP64"/>
    <dbReference type="InParanoid" id="A0A194QP64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7370" checksum="67DF2CDFF258968A" modified="2016-10-05" version="1">MVATASGSKQNEGKGRGGWRCEIPYGRATSRSFALALAYTRALKGKKGFLRKEQTVSLVTSLLRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQL9</accession>
    <name>A0A194QQL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 184B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQL9"/>
    <dbReference type="FunCoup" id="A0A194QQL9">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QQL9"/>
    <dbReference type="InParanoid" id="A0A194QQL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="44233" checksum="D5A775B8AFACC602" modified="2016-10-05" version="1">MIVGSASGMGGMNKIVSLSNNGSMGSTETINVTAQPIAAAVHEMFKPLQQPVFLQTTSAKVITGICVWTALFITCQQIYQHLRWYTNPSEQRWIVRILFIVPIYGCYSWISLLFFNGDSYYVYFFTVRDCYEAFVIYSFLSLCYEYLGGEGNIMSELRGRPVRASCVNGTCCLSGATYTIGFLRFCKQATLQFCLIKPLCAFIIIFLQSAGHYHDGDWSPNGGYLYITIVYNFSVSLALYGLFLFLGATREMLKPFDPVLKFFTVKSVIFLSFWQGMTICSLAILEKAEVISPLVDASGVPTTAGTVSAGYQNFLICIEMLAAAVALRYAFPAAVYAPHRDPHRSVTMQSISSSLKETMNPKDIMTDAFHNFHPQYQQYTQYSSDVTSHLPYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRC6</accession>
    <name>A0A194QRC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">15-hydroxyprostaglandin dehydrogenase [NAD+]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRC6"/>
    <dbReference type="FunCoup" id="A0A194QRC6">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRC6"/>
    <dbReference type="KEGG" id="pmac:106718529"/>
    <dbReference type="InParanoid" id="A0A194QRC6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="272" mass="29246" checksum="FEF378DB95A540FC" modified="2016-10-05" version="1">MAYDLKDKVIFITGAATGIGSRIVRIAVAEEAKHVAILDIAVEAGIAFQNELNSKYGNNKVQFIKCDVTNTEELNAAFAKVKDEFGYIDIVINNAGVLNDNLQVYVKQININVTALVTSSLKALELMRKDEGGKGGVVINMSSIAAICAVPDTPIYSATKAAVLKFTTAMGNDLYYSRTGVRFLTVCFGATDTPLLSVEKMGSFDSKVEAGIPETFKKLKWQSPEAAARGVVDTYKNGASGSVWLIAGGKPAVEVTELYNKGIALFDHLIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRG3</accession>
    <name>A0A194QRG3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MICAL-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_14568</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRG3"/>
    <dbReference type="FunCoup" id="A0A194QRG3">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QRG3"/>
    <dbReference type="InParanoid" id="A0A194QRG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF84">
        <property type="entry name" value="ALPHA ACTININ 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="12">
        <location>
            <begin position="780"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112190" checksum="EB3BF645C802EB0E" modified="2016-10-05" version="1">MSEVKGTKALELWCKRLVKDCPNIQIDNMTTSWRNGMAFCALVHHFRPDLIDLSKLKPENIYENNQLAFSIAEKHLGIPALLDPEDMVENDVPDRLSVLTYLSQFYQRLSHTVNTKATEGEPKVSSPTTKHPVTPIRFGKTGLDKCAACGLPVYLAQRLMVDHKLYHRRCFRCSKCSGHLNPKNYQVDDTSEFCCDACKNEKNFNSTKIFNNNDQMGMLAYSGDASDSKTDPCNEEQVSQRLKTRPQSVLDKISMFEKNVEKDTSIDHKLANISLKDSTKDKLKVDKSLDIENSSKDQVFSSKVENMELNKSINLNDDVISFNESFYKKVPDNIYKSNINKFNFLQTQLSEDNVITETASNSSEHVKDKPKQEDINLTTANRSSIYDDILSNKLEEPKEESNITDDSRLAKSNLNVSNSNTSAMLESKNSVKDDSEKSISVPPRRKKHNTSIDKATNGVKKEVPNKTIVKNQEYPDYLNPFSDDDEDEKVTPIEEPKRVSTNPFGSSEDEDEVPTVQIPQNKELQTPIKRHVIAQNPSNPFWSDGEEPSSDEETYQRSSNLYKSSMATSTPNLPSSTPRRKKPKAPAPPPTITISEAQKADRNSMSVSMDDVASISSLSSHTSTVYSDQCVYGDKRSYLSGSNLYKSSMATSTPNLPSSTPRRKKPKAPAPPPTITISEAQKADRNSMSVSMDDVASISSLSSHTSTVYSDQKSIGTITPKSKKKRHAPTPPDSLSTLSGCGAESMEKGVDTSGTRSGASDEVSAVGRRVKGPAPGLPLPARRAVRLQLSGEELQVQLDLLETQQLGLERQGVLIEQMIRDKCEGDEAVSVPQEEIEDLVIQLCELVNEKNDLFRKQTELMYIRRQQRLEQEQADIEHEIRIIQSRPAVNRIDSDKAREEELVTRLVEIVRLRDELVQQIEAERRRERQEDLAIAASIATKRAQRNSDSNASSIKSTETIVSPKKNKVKDKVKKQLKKAKHTLISKKKDEDKLEKEKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSK3</accession>
    <name>A0A194QSK3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MPN domain-containing protein CG4751</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSK3"/>
    <dbReference type="FunCoup" id="A0A194QSK3">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSK3"/>
    <dbReference type="KEGG" id="pmac:106719833"/>
    <dbReference type="InParanoid" id="A0A194QSK3"/>
    <dbReference type="OrthoDB" id="167806at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08067">
        <property type="entry name" value="MPN_2A_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000053">
        <property type="entry name" value="MPN domain-containing protein CG4751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040843">
        <property type="entry name" value="RAMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18755">
        <property type="entry name" value="RAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="240"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="897" mass="98166" checksum="E723B652ED7483C8" modified="2016-10-05" version="1">MDVQTSHLAAALMSTTSTYNNNVTTSETLTTGSNSGQDENKNEKPIETNKEPCEDEKDETGTGDEFSDEESEAQPGNKSMPGRGVTLQMLMEEKMLVPGIAAMTIEYLGQKFVGDLQADGKIKSHETETIFCSPSAWAIHCKRIINPDKRSGCGWASVKYKGKKLDTIKATYLRRKQLQRENMHSDEENEMEVESPPEPPPQRVVMKHNTVPNRMMQHDANMLIEAVSFSTAGKVQPFLVSVSSNASLVLDLHCHLKKEEVHGYLAGTWDLNSHTVMITHTFPCLKSKNDPRPKVLIELEIQMEMERLGLTLLGWYHSHPTNPAMPSLRDCDNQLEYQIKMRGPSEISYVPCIGVICSPYNPESPVLESSLTFFWVMPPPEQRPTEYPRPLFLQYNMVHDTHLSPHAMEQIKKTIKYYFNYADETFIKFKDNYKPDITYLDKLKSTLTPKFPREQSDGLLWHFIRDELGCSSEQDEKIDLDALLAVPQPIPPPKTTQSTSMPNFPSVSTLQQMVSRPAGVPPINVSSGIGSISPHKFETPQLNIPVLPTSSKSSKSSTSSLSSAYPTGLDMLTSMALGLGSANMPLPLGAGSLESLAAANSMLTGLTPGLSSNLAASLSSTKLSDPPSYAASLQNLTSMAAYEKTSTSTSTSNTTSTAPIPASIASSLMMSSADIANALFSASKYSSAGILGIPDPMSKSTLAANNMFLTPSLLKMQESLLKPLANSSPISSKVGLDQNVLMKSPHDLLKGSKDYLPPDFGSIGKGKMESSLDTGKHTESSSKADSSKPIALTSDTATDFSMPSRVCGESFLNQMLELTKKTTMPDYMSDYNQPLKLTEEETSTVSQSSHSYPNTSSIVDTIAQVAMGNYSKMDEVMDYTKGQDYSTSKNSSNENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT21</accession>
    <name>A0A194QT21_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT21"/>
    <dbReference type="FunCoup" id="A0A194QT21">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT21"/>
    <dbReference type="KEGG" id="pmac:106718129"/>
    <dbReference type="InParanoid" id="A0A194QT21"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="244" mass="26202" checksum="E06230DFABD8393E" modified="2016-10-05" version="1">MEISFRGKRVLVTGAGQGIGRGIAEQLWRTGAKVVAVSRTRSHLETLQNEYPSIDIVELDVGDWDKTREVIESLGHFDALVNNAGIGLCQPFLECTPEAFDTTMNINLKSIINVSQVVAKKMIENKTQGAIVNVSSQASKAALKDHTIYSASKAGLDAITRAMALELGPYGIRVNAVNPTVIMTAMGRIGWADPDKANTMLSKIPLGRFGEVSEVVDAVLYLLSDKASMINGVELPIDGGFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU40</accession>
    <name>A0A194QU40_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger protein 512B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU40"/>
    <dbReference type="KEGG" id="pmac:106717129"/>
    <dbReference type="InParanoid" id="A0A194QU40"/>
    <dbReference type="OrthoDB" id="6937274at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18774" checksum="F2529A3964CC9AE3" modified="2016-10-05" version="1">MNQGAVLCNSRTYARRIYKLVEGLDQAESQQDSAGLLYHSQSSKTSKMYAKLALLAVVIAVTVAVPTPGGYGHHKHVTIHVPYKIHTIHHHHVSKVHVPVHVPVIKEVPVIKEVPIYKHVPVPVVQHVPVPVIKKVEVEKQVYVPVHDHHEEVHHGWESESLSHGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV93</accession>
    <name>A0A194QV93_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV93"/>
    <dbReference type="FunCoup" id="A0A194QV93">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV93"/>
    <dbReference type="KEGG" id="pmac:106717130"/>
    <dbReference type="InParanoid" id="A0A194QV93"/>
    <dbReference type="OrthoDB" id="9994231at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="28307" checksum="45FF4518892B0F37" modified="2016-10-05" version="1">MPKPVCVQCKTKDSLLWRNVENGQICNDCHLSNTVKKESKLDTAVAKSESDEKTEGKDNEGKNGKSDESKPAKATGKGTRKSTRATRYKSKTQAPYSKTSVPRGRGRRSIFKRQPVKAPTATATVVTSDSIFYKGSYMQVGDIVAMMHIDGGVYYAQIRGFLTDQYCEKSAVVTWLIPTRASPPPEEGFDPATYIIGPEEDLPRKLDYMHFVMHAPSDYYKDSKSPYPVSESKLNDSSGFIWTTLEPKEKPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVT5</accession>
    <name>A0A194QVT5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVT5"/>
    <dbReference type="FunCoup" id="A0A194QVT5">
        <property type="interactions" value="1428"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVT5"/>
    <dbReference type="InParanoid" id="A0A194QVT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="249"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="443"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ09429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="627" mass="70531" checksum="6ACC54D0F5F852A4" modified="2016-10-05" version="1">MDEQKVLSIKGLLDDTPEEYLSHKEKYENSIRKSVLFYKTLHSTEDENMSVDEKTKLNFRNIVTSAIFKDNSPFMLHNSMFIPTIMGQGTDEQREYWMKRAKNMEIIGTYAQTELGHGTFIRGLETQATYDPDTEEFVLHSPVLSSYKWWPGGLAHTANYCIVMARLYIKGKSHGIHPFMVQIRDEETHMPLPGIKLGEIGAKLGFNTVNNGFLGFENHRISRDRMLMKNAQVLKDGTFVAGSNSKLTYGTMVYVRVLIVSNMANMLAKAVTIALRYSAIRRQSQPKPDEPEPQILDYVTQQHKLFIAIASSHAFYMNAMWLWEIYYSVSLQLASGKLDNLPELHALACCLKPLSTIDATAMIEKCRLACGGHGYMLSANLAQTYGLATAAYTYEGENTVLLLQAARSLVKAWVGHVKGRPLKGTMAYLAGDSTVKAWDGSIDGIIQSFKVVAIRKISSVVKILQDYEKSGLSPEDAWNKASVFLTAASEAHGRAVLLSVYKSEMDKRAAVLSPPLRKVLLQLVDLYVTYWALEKVGDMLLYASITDKDVDELQRRYIELLAAIRPNAVGLVDAFDFRDEILNSTLGAYDGRAYERLMEEAMKSPLNAEPVNQTFHKYLKPFMRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVW7</accession>
    <name>A0A194QVW7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette sub-family A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVW7"/>
    <dbReference type="InParanoid" id="A0A194QVW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="198"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="508" mass="58394" checksum="21936F332F004D67" modified="2016-10-05" version="1">MGSIPQAYLFSLGPQGALNSMIFIIVNIMLGETAIIAKIQFGEAWSYILQFSSFSPQFNLAHAYDKIKRNFLYNMECGIFESKNLCSMETLHKCCEKCGVLQQCFKRRCYLFDQENGIFIELVAILTTCCVFMIILLLWEYRMIQHLWMFIVKITCYVKYASDPLAFGVQKEKEDAVEKEKILKTDKKLRVKTFGEYLLAVDVTKKHIGECIIRHLYLGLEKGEVKAVSGLVLHGRRNLCEILAGYKIPTDGKLWAMSTWEVRRHPHKYARNVALCSNRNPLPPWMTVFEALKLLATLRGVPINHVKHEVENYINSLDLHEKANTFIGDLQPMERTKVHFAAAVVGAPPILIMDEFTAHQKYSVRRAMYFILRQLKKRGHAIVTGSSSVEAHLPMTNRLGILLHGLIYDIDNIDVLVERCGKSGFTVVLHLKDDVDVKTMLYRYFDMFVINDMSEVLVNVQILDSDLTWMTIFEKLEMLVAENATVYTYIVTAIPIDYIYNWILAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXL3</accession>
    <name>A0A194QXL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division cycle protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXL3"/>
    <dbReference type="FunCoup" id="A0A194QXL3">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXL3"/>
    <dbReference type="InParanoid" id="A0A194QXL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF52">
        <property type="entry name" value="PROTEIN CORTEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="432" mass="49673" checksum="4ACF30EF141E50AB" modified="2016-10-05" version="1" fragment="single">NTRRRQSDRFVPAREAVEEKRRRFSWPCPTESCDLWDSKYLQQKKHAVLLYGVLGFDDLNKYEEQMIPAWPCVPRQRKYLAPADSILDLPRYGEADFPELLDWGSDNVLVAALGHIYHKWSWKTQDIIQHSTTSNQTMCCKFHPRAEYLALGTTGRRAEIHDNELSKCINNSYCNCDLFLGKNYNCAITAFEWSPTGNSYVMQVYKGCSEGRIRSFTIDNRPMAERRIAKVAISLLRISPDARFLAVTSILHDDTYLLCWPSFELYSTLVSPNWTVKALNWHPWRSALLGVGTVTKDIHARIVMWDVPAGKIAEYDLSDKNYYLDTMRFNHKSGELVVSLYNPNVANGNSQLVVLSDHDKAVDHWGEGRKFPDRVRYMIFNPDGTLLASATSDEDLIIWKFLPEDKKRKTKSKSFSAMPVYLDITSIGCSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXW5</accession>
    <name>A0A194QXW5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXW5"/>
    <dbReference type="STRING" id="76193.A0A194QXW5"/>
    <dbReference type="InParanoid" id="A0A194QXW5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="9984" checksum="23CD2EB3F6EA9D4D" modified="2016-10-05" version="1">MKPIKMTHCPLKTPKKMSKKSNLEAAMSSGTSKASESTPLITKTNDSGEEIKKGSGLSVNQAALLVAGEMAGSGVLALPRALVKTERVVVSNEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY40</accession>
    <name>A0A194QY40_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DET1- and DDB1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY40"/>
    <dbReference type="FunCoup" id="A0A194QY40">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QY40"/>
    <dbReference type="InParanoid" id="A0A194QY40"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033575">
        <property type="entry name" value="DDA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018276">
        <property type="entry name" value="DDA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31879:SF2">
        <property type="entry name" value="DET1- AND DDB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10172">
        <property type="entry name" value="DDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DET1- and DDB1-associated protein 1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11553" checksum="769A0918CC92C845" modified="2016-10-05" version="1">MEFLKDLPSYDEHNFTLFNTDSGIRNCSKRPSIYLPTKDIPSDQIIVTEKTNILLRYLHQQWEKKNNNSPKKRDQGHIEQNGDESRPRKRPCLNSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYB2</accession>
    <name>A0A194QYB2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYB2"/>
    <dbReference type="STRING" id="76193.A0A194QYB2"/>
    <dbReference type="InParanoid" id="A0A194QYB2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="516" mass="57115" checksum="0DFD5EFF18DCA43E" modified="2016-10-05" version="1">MADEVDDKASGDVASEASEEKSVIPEPEPIKVPDVELTVDGFGFMSKQSSIDKSKKNGRRKSKELKEILAPEAEASPCSSSSNIDIVRRFTWKTKNRMTVQVITYGATITTIQVPDKKGVPDDVIAGFDTLEEYFQPRNPYFGATIGRYANVIRNATMSVRPMGRMYMLSSNLGPNHCNGGYVGFDKVNWRSHVVGNKVYMSHVSDRFHEGYPGTVMTQLCFEVTCDNTINIEMKCTTTEPTIINLSNAQYFNLAGHHRGAESMYEHIITINADKYTQVDDDGLVTGEKKVVGGTAFDFRVPRCLKTMLPKIPKGGYDVNFCITQATAQDLTFHARALHPDTGRVLEVYSNQPGLQFYTGNRLPDPDRIVAALSGGEEEGAEQSESEASAEDEEFRDVDGGSDNQGDGKEHYGYVPLAGKNGTFYKKHGLFCLLPQNYPDAINHRRSVLKRKCAVRFVDEACSSRGLAVRCSLARPSALNIRHSRSDACEARTVPTHSPQRAQNLEPFQSRSNLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYC5</accession>
    <name>A0A194QYC5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_09601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYC5"/>
    <dbReference type="FunCoup" id="A0A194QYC5">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYC5"/>
    <dbReference type="KEGG" id="pmac:106715766"/>
    <dbReference type="InParanoid" id="A0A194QYC5"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000027">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="204"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="13">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="496" mass="56174" checksum="9C7E65777ADFF497" modified="2016-10-05" version="1">MVLDLDLFRADKEGDPEKIRENQRKRFKDVALVDTVVEQDLLWRRLRHEADNFNKLKNVCSKEIGQKMKSKEPVGPEDQEVPASVADNLVNLTAEQLRPLTVNQIKKVRILIDEAITKNEQGLITAEKARSAALREVGNHLHPSVPVDDDEDHNLVERTFGDCAMRQKYSHVDLICMIDGMDGDRGTAVAGGRGYYLKGPAVFLEQALIQLSLRILLKKGYTPLYTPFFMRKEVMQEVAQLAQFDEELYKVIGKGSENKGDNIIEEKYLIATSEQPIAAYHRDEWLAESSLPIRYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKVEQFVLTSPHDDASWKMMDEMIGNAEEFYQTLGIPYRIVNIVSGALNHAAAKKLDLEAWFPGSGAFRELVSCSNCLEYQARRLLVRYGQTKKMNAATEYVHMLNATMCATTRVICAVLECNQTEEGIKVPEALKPWMPEQYQELIPFVKPAPIDLEAAAAAKKGKKQKEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZT5</accession>
    <name>A0A194QZT5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-hexosaminidase</fullName>
            <ecNumber evidence="10">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="10"/>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZT5"/>
    <dbReference type="FunCoup" id="A0A194QZT5">
        <property type="interactions" value="1283"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZT5"/>
    <dbReference type="InParanoid" id="A0A194QZT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF3">
        <property type="entry name" value="BETA-HEXOSAMINIDASE FDL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="11">
        <location>
            <begin position="155"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="527" mass="60200" checksum="06A8620787442390" modified="2016-10-05" version="1">MLCTTIQLWPQPTGSVSLSTTAVPVRADLFQLQVLDFTSQPVLEHLQNAFDIFRQELSFTEEQLRGFDEWYKVVVRVRINGSGDPRMRLDTDESYALSVQPEVGSVGTMAVYIIANSFCGARHALETLTQLIWLDPYAGSLLMLEAATIQDAPRFRYRGLMIDTVHNYFPVEELLRTIDAMATCKLNTFHWHATGAQAFSIMFNSVPQLAKFNAYGNTTIYTPDDVRTIARYARFRGIRVILEINVPAQIGQAWDWGPDLGLGELAYCSNLEPWYLYCDEPPCGQLNPRNDHIYNILERLFLEVTQLTGVDDLYHIGGDGMSDRCWTKYFNDTEPMDLWVNFTRKTLQSLQKVKGNLPKLTLIWSSQLCEKIKTDLKEYLNYIGLQARNVAWNENFVRGLRTVLSNEDVWDLNSGMGSWHEDSEGAPYNSWQKIYEYRPWASSSLGLLEGGEATVWSATLGSGGLEQRVWPRAAALAERLWSDRPEGATRPVQARLDVYRSRLNTRYNVKAEPIWSMWCSHNTYTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0B2</accession>
    <name>A0A194R0B2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Down syndrome cell adhesion molecule-like protein CG42256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0B2"/>
    <dbReference type="STRING" id="76193.A0A194R0B2"/>
    <dbReference type="InParanoid" id="A0A194R0B2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000230">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000310">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF56">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264786" evidence="3">
        <location>
            <begin position="21"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="518"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="895" mass="100237" checksum="C8318C5BB9726936" modified="2016-10-05" version="1">MMLPVLTALVALLSIGAVHCEDETIGPIFMKEPPNRVDFSNTTGAVVECAARGSPTPDVIWVRADGTAVGDVPGLRQVLPNGNLVFPPFRAEDYRQEVHAQVYACLARNPVGTIHSRDVNVRAVVAQRYDTDVNKEYVIMGNSIILKCQVPSFVADFIDVLSWHTDENEDFYPGENYVVQQQYESEVNNEYVIRGNSAILKCSIPSFVADFVNVVSWHDEAGNAFTPTENEEGNVVTQYYEAEVVSEYVIRGNTAVLKCNIPSFVSDFVKVEAWVASDGDEYLLTNHTVVNQFYEAEILTEYVIRGNAAVLKCSIPSFVADFVKVESWIDEEGTVISYSEDLVVSQYYVTEAENEYVIRGNAAIVRCKIPSFVSDFVQVEAWIMDDGLILTMNHTNIVDVVSQSYEAEADNEYVIRGNAAVMKCEVPSFVSDFVYVEMWTDSDGGTYYPGHSEAVLQTYEGRVNDEFVLRGNTAVLKCIVPSFVADFVHVVAWIMDNETVLAEENPNYDSVVHQNYEPRVIDEDVLRGNSAIVKCTIPSFVADYVQVVEWVTDDESLPVFSLSDSESNYAVNQFYESQVYDIYVIRGNAAVFKCHIPSFVSDHVHIISWHDSEGGEFLNNENYAVSQAYNVNLWEENVLRGNAAILKCHIPSFVSEYVTVTSWIISEGDVEEMDIQLASQLNLVVSQAYDVKFWEEYVLRGNAAVLKCQIPSFVAEYVSVSSWIISEDENEQEIKINDSDNLVVSQAYAVNLMEEYVLRGNAAILKCHIPSFVSEYVNVISWIISEGDEELEIKLESDENFDEGKYLVLPSGELHIRDVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGRVPPKFPSSSQITSGFLFRESSSVAVQCPAQAYPAPMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0D0</accession>
    <name>A0A194R0D0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0D0"/>
    <dbReference type="STRING" id="76193.A0A194R0D0"/>
    <dbReference type="InParanoid" id="A0A194R0D0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="880" mass="98380" checksum="AA1D4856F4A9C375" modified="2016-10-05" version="1">MSLNIEKVVEKNPRILDLREKLNEITKKQDLKDAKTKSYLNDITQQFVEDTNESGPYSLLFDLQADPSTSCVKVNEGESWKRSQNDVSTDNAPQIINKITTSTNKSLERLPNVLNFDDKRMKEFEYSCEKEVPIPIKTTFNTHSRSDLCLQLKSHVHPRTYETNLSPNENSMSRNNEENSLDDSLGILTPDQMDDICYLENAFSPTVEGLPIFCDSGDYKASPDNGDTPSTDKTESNSAASTIQNETFETVNVKKGNTFSSSMAPIISLKALQIQNKNELSNDINQTSVLNLYDKTFCSLLDTKKETKNCSEAEDNIELYKSEELTQNLVDEEFMPSIHGSILEPASSIADTTINLEIPLDCKADNRNASNRIEQTPSPEDLPLDSSEINGEISTYSQFSASTLHDSQTFSDSKNDYTKSMETSKVSNSFITSITSITSLDGYQGDGEMSRPVSRSADHPMEPREDVIDMDWQNVPVTRRIDPMTDSDFFTESDADGLDEHMQKGDRRAQVIDGALYGGKNGNTNAPLIVTRSEDSCMESSGVYTDFENHRASPVFLHVIKDMSPDSTPSTRSECSQKDSSSNKLNAYFTPLEDTLEEQNSDVSHVIDDDITPKNTSKRNSINSEKDVRTIDKNKEEKRSFTLKKYKMPKRDVPSKLKTMLASRKTDADASIQNSPKATKKSERRESFLKKSSMEMKNDYKMKSFKDIKSKVDCTFSLQRSQTACSVTRMLSAKSTNMNTKPKSRHMRMRMDLGSANGSGKSSLHSSQSDISATSTPLGKHTTSRFPLLTCYCIKNQLFVVDKAIQKVDITTSSGRTAWLLVFPPECDESAAFGSPIRSPVAGETRAGARRLRHTVASVTSTCNAKNQWIQIQLFTLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R172</accession>
    <name>A0A194R172_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R172"/>
    <dbReference type="STRING" id="76193.A0A194R172"/>
    <dbReference type="KEGG" id="pmac:106715199"/>
    <dbReference type="InParanoid" id="A0A194R172"/>
    <dbReference type="OrthoDB" id="7468199at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29760" checksum="E9F67CCDD6E8F6C8" modified="2016-10-05" version="1">MKEKFLDGETDSYDCECYDKETLQSHELVESKATSKYGDLYLIGTVWVTVTKSALLGASSLIPMVEAASPPPPPPTKPPLMKYKELPMYKSPHNEYKEYLEEKDKCPERNVKVMRRFLLPYVSIIRKGVQANTCKLVLGIRDGVCSLQKSVAESKKQFTATMRDNENLTIRRAVVVAGTGIGFLLGGGRGIPRRVFMTGAGAATAGALCFPKETDEAFRTFTYYSGKTILGIANLICGRDFGWRERLPCKDDLPVSSGKIVGQCPPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R359</accession>
    <name>A0A194R359_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R359"/>
    <dbReference type="STRING" id="76193.A0A194R359"/>
    <dbReference type="InParanoid" id="A0A194R359"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="26704" checksum="C631C2782BA9BD03" modified="2016-10-05" version="1">MDRLESGLDICVCADDDVCLNRTVYAIKTETEGRCLPELCVHLFHEYGLISHYRLDAATLWKLFSLIEEGYHSSNPYHNAVHAADVTQAMHCFLQQEQILPFMEPQELLACLLAAIAHDLDHPGVNQTFLIATSNYLAKLYNNTSVLENHHWRSATSCLIESGVMESLRDIWSSLQDQISALILATDITRQQEYLSHFKLQDFQHNVLVERDAKLFMYAIKQAMALDVSNVIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3R9</accession>
    <name>A0A194R3R9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin glycylase 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3R9"/>
    <dbReference type="STRING" id="76193.A0A194R3R9"/>
    <dbReference type="KEGG" id="pmac:106714235"/>
    <dbReference type="InParanoid" id="A0A194R3R9"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="742" mass="86453" checksum="EF48B3DBF9453560" modified="2016-10-05" version="1">MYKNTIRSLGLTSKEKSYIISSLQNKSSRYTKLKDLASKAKRENKIFSIFGTCNAVRKALVQRGWVEKIPPNRINMFRINSGKISSKTDIHYELERLMLSNLVEKCNPNFVWRDTQQDYDTAIDMKNECKTIVNKLKADALWTTKQGLCTYMKINYWFYIEDVAEVCCPRSYNSYDTGEIEEFIADYRITACTSLIQWVISMLANNVTIFTETGTIPIKVITFALNRCKEYLLQKRNRDIDYPIKPVSTKQWNAFLKKYYRLITNKELFEADKENRLLLYIGYAQFILEKMYIYRPQVRCEGYQNIWIIKPGHWSRGRGIRMASKLGVITELLNKANAKYVVQKYIEKPLLIHETKFDIRQYYLVTSTYPLVIWMYKDCYLKFSSQKYNLDNYHESIHLTNNAVQKKYNNYAGRHPELPMNNMWELNMYKKYLSKIGGDGVWEHIIYPGMKKSIIGIMLSGQDSLPLCKNRFELYGCDFLLDEEYTPWLIEINSCPDLTNTTEVTAKICPAVVDDVIKVVLDHAIDPKAPTGMFECIYQQPMTVPRFSTSTELVVRGYPLPNDYFYKGNPSINQIKHFGDSSDENEDESSLNKLKSIYSDDAIQDQFCDMNFNDNKTGHKKQSGFTSDSENFDRNDSDIFPSAITDILRTKKKSLFQTHVLSNLNLFNAIFNQSLNQYPKKYKKNQKSSHRNMKDRKNSKSVTKSFDSSSGNIDNKLKDYVLQASSDILTFISEKEKVYNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3S0</accession>
    <name>A0A194R3S0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAPS transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 35 member B3 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3S0"/>
    <dbReference type="FunCoup" id="A0A194R3S0">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3S0"/>
    <dbReference type="InParanoid" id="A0A194R3S0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="38398" checksum="FED385C34B4DCECC" modified="2016-10-05" version="1">MNSSKETIIKIDTLPSGKDNSNTEINILCFNITPYSQLVQFLCCSAFVFVCYLAYGYFLELIFSKAEVKPVSLYITLIQFLITMLLSYVESLIRNPIKRKVPLKTYAVLAALTLGTMSLSNLALSYLNYPTQLIFKSCKLIPVMIGTDSKTSPNFNVVGVLVISLALLCDAIIGNVQEKAMKQFFASNNEVVFYSYAIACCYLFIITCATGIFVDGFTYCSQDAMSMYINIFLLSVSGYIGLQAVLTLVRICGATVAVTVTTMRKALSIVISFLLFSKPFVFQYVWSGMLVALAIYLNHYSKKHPHYVPQPLRLCWHFVQSFYQSEYKYLKMKSKIYADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3Y9</accession>
    <name>A0A194R3Y9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Testis-specific serine/threonine-protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_06663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3Y9"/>
    <dbReference type="STRING" id="76193.A0A194R3Y9"/>
    <dbReference type="InParanoid" id="A0A194R3Y9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14080">
        <property type="entry name" value="STKc_TSSK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="572" mass="64269" checksum="ED80C7BBA905B75B" modified="2016-10-05" version="1">MGQGDKLELSTTPSDLNVLQEKGFILEKIIGEGSYAKVFKATQMMDETRHCILACKVIDTAQAPRDYLSKFLPRELDVLIRVNHPHIINVSHIFQRRAKYFIFLRFAENGDLLDFLSQHGAVPENQSRLWMRQILSGMQYIHSMNVAHRDLKCENILITANYNVKITDFGFARNVRQRDRDILSETYCGSLSYAAPEVLKGVPYLPKMADMWSIGIILYTMLNKALPFNETSVKKLYEKQIMRKWRFRTNIVNQLSTECKEQVTALMEPDPKGRPTATAIVAGPWIGMDAKLAKLTFLEESLLKQAEEEAHMKEKDNYVESEVERIAELRRKGRGKGMYIITFVELNIPTAGNKAAYSEVLRIKLLQSLQALGNWKSVIEAPFQFQLTVQQVIDLLSETNGANDLIRNLYQTVTGKQQRITLEPLTSATELLFCCSQRSIALAVVKSGRGGGGMACCSEEASCCANSNARARAARPGPLGVVAPVAVPPASVDTVCTKVITGTEDRHKFSDIEQTKTLLIFDPTVFYINFVFFISEGRADLEVPTLRYRAAVICPCHIKAFGMTISSIDCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4B2</accession>
    <name>A0A194R4B2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibroblast growth factor receptor substrate 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4B2"/>
    <dbReference type="FunCoup" id="A0A194R4B2">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R4B2"/>
    <dbReference type="KEGG" id="pmac:106714068"/>
    <dbReference type="InParanoid" id="A0A194R4B2"/>
    <dbReference type="OrthoDB" id="6279276at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01202">
        <property type="entry name" value="PTB_FRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038742">
        <property type="entry name" value="FRS2_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF55">
        <property type="entry name" value="FI23523P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="7">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="513" mass="57296" checksum="A6F0B3344299639C" modified="2016-10-05" version="1">MGCLHSKKQVIDLHPNVFRVLNIDENGVEICTGQLEITESDIVLYREGRDTTVWPLHSLRRYGFEAEVFSFESGRRCETGEGIYAFRCRRASSLFRTLQQQIQLRNVIHDSVPYPVSRLTPSPQGRQTLQASVVHRSSIDNGQVDVAGAARNSNLSNVASHNTVMRNATQSPRSPSSADILEVMPLNPRPQAANSQVTNVYQVRDFKREHNNNQDAATSTDTRHVYSNDISRDLAVLRNTLRQETALSTMKDIEDETRYLESRYINENVSKNSVNKALSPTLSSNSEHYAQLSIEQQEATRLYVNVAPADTNLPETEKNDPIPTTPLTPKQVEYCNLTINNKQEINCYANLLLGEIVENSKNLKSSLHFNIPDPNQKFSESDTFTSMSPVEELEVNYAILDIDTSKDYSKAARELVSPESQSYASSKNESTTSHSSQTRGRLVSQNSFDKTTTTNTLSTVTPLNIGYTTIDFDKTVALTSVASEDVSDYSRKTRHNSCSIACGSPGVIDKTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R577</accession>
    <name>A0A194R577_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_10196</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R577"/>
    <dbReference type="FunCoup" id="A0A194R577">
        <property type="interactions" value="1914"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R577"/>
    <dbReference type="InParanoid" id="A0A194R577"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="428"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="543" mass="60764" checksum="E30DE26725C7D191" modified="2016-10-05" version="1">MKNSGNHNIRINEYKRVEISEMTSQDTNKVLQYPKPRMLSRGRGSASTIRITNVKSIKPPDNDVIKKQEEEKLRAQLQKEIMSRSRSCAYRGYVCQLAVLSGRQHCARHILHEPGAPYKQCVHTYAGGQRCNKPAPIPPANTQSRDAGLCFEHARAALYSRQRSAAPPPPVTTTETLLNQLQHYIRPERTRTTSCASSVSVVSEPCEPDLISPNAVDPFSEVDLTEEWTHRKVKYSLSVRLIRRIKVEQIDATAVNASYSSSIMECASASESDCDSVTLGPDGDCRALHEDNLSDAEEAPCESQPLWRAGVYTAEEAVSETKTVLKSLQSAYIRQMGRLRILLQSARYQYIKSLKAEREQYCSINAQARGGPLTVRERRQLRKLKAYAGYHRKHGVDAVLARKLHRKRAKVNDINPHRFVPTPSRCTFAEGGVRCSSSALPAAKHCLKHILHDRHQVLFAACGDERGCAPCREPVARLPLPHTCRYHADPPPYQVFTLKKDESDSDTESQFSSSGSHTDLGEQSFEDKCEAAPDAPSDTLQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5Q9</accession>
    <name>A0A194R5Q9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_14840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5Q9"/>
    <dbReference type="FunCoup" id="A0A194R5Q9">
        <property type="interactions" value="2165"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R5Q9"/>
    <dbReference type="KEGG" id="pmac:106714836"/>
    <dbReference type="InParanoid" id="A0A194R5Q9"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000826">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="356"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ11201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="447" mass="51483" checksum="12AF166289124F61" modified="2016-10-05" version="1">MSNVKIKVISRNPEDYLRSTKRDIHKLPRNYDPSLHPLEAPREYVRALNAVKLERVFAKPFIGSLDGHRDGVSSMAKHPDKLAVLASGAFDGEIRLWDLAQRKCSRNFVAHEGWVRAICFTPSGETFTSVGDDKTIKTWKSQTQSPEDEEPVNTLLSMSVVSGITHHRNKPIFATCGEHCQLWENTRNEPIKVFKWGVDSLHHVAFNQVEYNLLASCASDRSIILYDCRESGPLRKVVMELRSNALSWNPMEAFIFTVANEDYNLYTFDVRKLNQPINIHMDHTSAVIDVDYSPTGREFVAGSYDKTVRIFESLKGHSRDVYHTKRMQRLTCVKWSLDNKYILTGSDEMNIRMWKARASEKLGVLKPRERTALNYADALKEKFANHPQIKRIARHRHVPKHIMNAQKELKTIREKSKKKEANRRAHSKPGTVPHVPERKKHIVKEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R642</accession>
    <name>A0A194R642_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R642"/>
    <dbReference type="STRING" id="76193.A0A194R642"/>
    <dbReference type="KEGG" id="pmac:106712808"/>
    <dbReference type="InParanoid" id="A0A194R642"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="52"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="601" mass="68614" checksum="4D9CBC1DFBB18255" modified="2016-10-05" version="1">MPSWGKVVLIAVLVAVAVGVVVGTVTWALMRSDSTPPDIIELDWWERTIIYQIYPRSFKDTDGDGIGDLRGITSELEHFVDAGVGAIWLSPIFVSPMVDFGYDISDFYDIHYEYGTMADFEELIRRAQQLGIKVLLDYVPNHASTESEYFKKSVAREPGYENFFIWADPKIDANGNRTVPSNWISQFGGSVWEWNEGRQQYYLHQFAVEQADFNFREPAVRQEMINIMRFWIEKGAHGFRLDALPHLFEADPRDHGGVFPDEPLSGNMFLTGDQVGYTTQEYVRDLIEIYDVVYEWREFADKWQEDNDSETIVLLAEAYANISMTMLYYGDERGRVGCHFPFNFDFITSLKAASNARDFVYVINRWLTYMPYGNVANWVFGNHDNSRAPSRFRTIMVDGLNALNLMLPGVAITYQGEEIGQRDGYVSWNDTVDVNAINQGNPDNYLEYSRDPARTPYHWNNSTNAGFTTGPTTWLPVAEDYMEINLQAQKDAERSHYKVYQYLSRLRGMASLSHGTHHLEALSVNTMVLVRHLATYNTYALVFNVGTEEDTVDLSRVTFLAEPITVYESSVFSRRRSGDTISLGELILQPGEAIVLRAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7L9</accession>
    <name>A0A194R7L9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat and calponin-likey domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7L9"/>
    <dbReference type="STRING" id="76193.A0A194R7L9"/>
    <dbReference type="InParanoid" id="A0A194R7L9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11876" checksum="C8999432A04E2290" modified="2016-10-05" version="1">MNGHNNIHSQLTKSLERILEDAYLSGELKLSGRKLREFPKPVKFDLSDTVLADLSKNRFSDVPDEVTTYVYLEKLLLSQNVIRSVPETVGGLQSLTYLDLRLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R827</accession>
    <name>A0A194R827_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R827"/>
    <dbReference type="STRING" id="76193.A0A194R827"/>
    <dbReference type="InParanoid" id="A0A194R827"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="558" mass="59484" checksum="4805AC850EF46F89" modified="2016-10-05" version="1">MQRRPGAPAPTVRAHLSIMPPAQPTFHSALSAMWAQGSQIIIVTMSTTILGLQLRVNDLAMRILADVKSHGPELAAESVPENAVNEVAEEAKSDSETKDEKTPETPVTEPITNGSNTPESPKTESSPTDEPIPETPEDNDRPEPKAASPEPKAATPEPKAAMPEPEKLPVNGLSLEEPKVEAPEVPKCEESSVEKVTSETSESVPAPEIPVTKEVCVEQMPLIEPSPPPLPANPPPSSVASFAATTMAPELTDASLATPTDVTTTAAPIATTEPDPDTDIVDRDALESNTAQLDAEKAVAEVPTAVTETVEVIKAPIVIDEVKPEQVNIPTSKENGVIDSNVDAMDGTKTENVATDTTPALTIVPDHVDIPEIVINESQPTNDLTHHDETDDQTQQDDDTYAAGDKEIISDKKIVEDKKIEEVMTTELSATTTEIENLKNSAKVVEEDLTEKKCNGLIEEEKNEAEITPADKIGEATTQEDSMPPPPPLDSQGDEVSDDAEETLPLPPCEPCPPPPATPPTQDVLPVSDKMADLIPEIPVVPELKTEMESSSDVAVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9N4</accession>
    <name>A0A194R9N4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_06701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KQ460761">
        <property type="protein sequence ID" value="KPJ12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9N4"/>
    <dbReference type="STRING" id="76193.A0A194R9N4"/>
    <dbReference type="KEGG" id="pmac:106713504"/>
    <dbReference type="InParanoid" id="A0A194R9N4"/>
    <dbReference type="OMA" id="MAWSINE"/>
    <dbReference type="OrthoDB" id="7248433at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="349" mass="38598" checksum="8CA4D028C898D31A" modified="2016-10-05" version="1">MLLAKLKSSKIFFRNTRKSQLTFIPLRNIQVSIIGSVGEVGSNLALLLKQNPKISRLQLYDDNESVNKLALELDCLPGGPTVSAFAGPSMLCPAIRFTDLILMVDRTHRKPGIKREQMIFANAPPVQKLCRAMAEQNSKAFLAMTTSPLNSIVPFASVLLLNYGSYNPFKVFGITHLDLARTRSLAGNVLQANPTELQIPVIGGHSDETIVPLFSNISPKTYEVSERQADMLTRLIRKAGVEVINKKYGTESASLSMAWSINEFVDCILDALRGAEVTVNTYTANPHFGTKFFSGPTVVGAQGLVQPCYEFKLNDFEDKLLEKAIPMISRDVAQGEQYVDVFESFVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAC0</accession>
    <name>A0A194RAC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAC0"/>
    <dbReference type="InParanoid" id="A0A194RAC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="14562" checksum="7C7B487A4A906D13" modified="2016-10-05" version="1">MPRVSRVLAAEAPRCGRGSLAVTNIGRAAEASATDVMRDPNEATSFVEPRDRRDNRTVHSEKSPEFRDMPSSEPLSLIVFLEEPLLWTLIDQLEKKNYKTSSPTRHNAPFSGSYVSSAAREQWTGRKQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB14</accession>
    <name>A0A194RB14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB14"/>
    <dbReference type="InParanoid" id="A0A194RB14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="32" mass="3241" checksum="E2C0D0A17834AD58" modified="2016-10-05" version="1">MEGPRPGGTAFVITVAPTPALVLNGGVPENDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCG4</accession>
    <name>A0A194RCG4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronosyltransferase 2B18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCG4"/>
    <dbReference type="InParanoid" id="A0A194RCG4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="20213" checksum="D41243EFC7B1D772" modified="2016-10-05" version="1">MSAGEPLIGIEMLGEQWNSSDKSIHPIHDKIDTKPDTNTLIEEKFDTALKTLLNDKRYRKNIVMLRQMMCERTQKPLDRAIWWMESVIRNGGARHLAPSTANIFGAQYLQSQTVFVSLTYVKEDQEGEEHLGSKIFANGTTKVRDLYFELPCRVQSSSYYDNRQPSLGDGIKRCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCT1</accession>
    <name>A0A194RCT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCT1"/>
    <dbReference type="InParanoid" id="A0A194RCT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="308" mass="32291" checksum="3F6002ED3B449238" modified="2016-10-05" version="1">MNQSVKWPSARVDSRALLVGGGCAGGGSTAEGVRAGAARASVRARSDPPGGFLREISKLSSFHLRRAARCSYSVLAAADQDSTESLSRSERPALAKSRSAYVIDGGESPRAGDLPDSRRADLAREPISVPDFADMILPTPVLSPVEAAKLVYLDSEDEEDIKRDTSRNGHAEEAKTPKTKVISIPKSASVRFIKGATGASEDEADLSTSDYASAEKVNRISGPSSLGFSNPHYLGPDVRNLGVAMTPDSGVGQGDIELQDLGVRRGGGAGGGARGGDTQLHLLLVGGKESPHLALLQSPLSMWTYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE47</accession>
    <name>A0A194RE47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bromodomain protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE47"/>
    <dbReference type="STRING" id="76193.A0A194RE47"/>
    <dbReference type="InParanoid" id="A0A194RE47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromodomain protein 4 C-terminal" evidence="2">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="518" mass="56357" checksum="3AE1BDB98043C49E" modified="2016-10-05" version="1">MKKQVQQLPSHTKSAPPVVVPVTVAPVVVEEPPQPPPADDKSEVPQHAPSPSPSPPRAHAAQPSPAAPVQPAQPAPAPARLPTPPDSSDPLLPPAPVLDAHEHKQIIKTEPRNGLDKIDTSQYIDPLERSLASLERSLKAEVPMDVTVSVAEPAMRMDDFPMPKTSLLPDAAHHSLMAQLGGLADITHVDHIKTEMYAQPHNGYVDKNPQLEREMLRPDVVATMASAPSMAAVTSMANMANMAIAPPVSSIFDPAFAAAHAPHAPHAPPAQPHPAVTAAPALIAPNVKKEEPKPLLTPKPIEDLMGVPNMGTNNVSERTKYEMEKKMEESKNFAQPFKIKQEQNLKNASSWSSLAQAGSPQNIPNIGTNNQVKQKPVMDSCFQAFKKQAREKIDRQRALLEQQELRKKEQAERERQRQETERRHPEDEKLRVVQNVRKAESAEVSSPSVSPVARASPPAAAAAAAAAAAAAQVAPDKPASERERLRQREQERRRREAMAGQIDMNMQSDLMAAFEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE64</accession>
    <name>A0A194RE64_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_09682</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE64"/>
    <dbReference type="FunCoup" id="A0A194RE64">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RE64"/>
    <dbReference type="KEGG" id="pmac:106710026"/>
    <dbReference type="InParanoid" id="A0A194RE64"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001026">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01223">
        <property type="entry name" value="Pmev_kin_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036639">
        <property type="entry name" value="PMK_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ15759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="186" mass="21697" checksum="3E290207F9661046" modified="2016-10-05" version="1">MPQVILLFSGKRKSGKDFLTDHLQKMLLDKCEVIKISKPIKSHWAKVKGLNLDELLSDGKYKEQYRLDMIQWSEEMRFKDYGCFCRSACQNAVDKPVWIVSDIRRKTDIQWFKENYSDVIRNIRITADDDTRKARGYNFQLGVDDVASECDLDDYNDWDLIINNGKNGQSLEEQISAILTLIQHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE65</accession>
    <name>A0A194RE65_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE65"/>
    <dbReference type="STRING" id="76193.A0A194RE65"/>
    <dbReference type="InParanoid" id="A0A194RE65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265129" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="28392" checksum="C1AF037F9E461730" modified="2016-10-05" version="1">MRSFICFAAFLTVAYAVQEIPNGAVGDEVCKEYNTYYKIQGSCDSYVECNAYKATYKTCPDGLYFIRDVQWPTYPCAYPSDAQCEYNDQPQRAISSAECKTQYGFFASPLATRSDCGKYRMCVEGKAFEMECAMGLAFNPETGRCDWPDLVPSCSAEEFLGFKCPPATYDEFGKAYVVNFSCHYFFSCMEGVARLLVCDRGFAFDASVNRCVDATKKHKYSSAVARLLVCDRGFAFDASVNRCVDATKVQCQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFC7</accession>
    <name>A0A194RFC7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA endonuclease RBBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFC7"/>
    <dbReference type="STRING" id="76193.A0A194RFC7"/>
    <dbReference type="InParanoid" id="A0A194RFC7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="73987" checksum="51CA0A4846D66503" modified="2016-10-05" version="1">MTNETKLFENFSILCTNPKVQALETTLLQSFANFKDILLEYEEIVSELESYKSQIFIQKEKCESKSCTSSESLKQIINEKDKLIQSIANILLEINETKNLDVITDALKIISGEMSPLSPQKSTSEALSPVFEPSSIYDKISSNFDKKFTSTPEVDSIPSGRKSPIIETKKFRITPDVAVENVVKEKKKCPEIWPTPEKKMLKLVFPTPGKSKSSVKLRQARLNFVKEKATSVVDLTCSPKESDYSNSMSQGIKKEVFENDDTILPSPTSGPINFSSVYKSICKSSPKKTKKSLSLNKLITNKEIICDNKENKSIKIEDKTEDDFEESNVLKESNKSNTTPKKFNTPLSKFKLKTECTTFVDENDENLSKEVTIDKDIEESINILRHYPERFTKSPSKPQSLMLNLQSQEANESISLLQRINQFDKKQDGGQPCSPTKRPSSPSDIPASLSVLSNNFNTKVSNNKDNKRTKPIPVEPIFKEPTVRKKAEKLALPGWSCDECKQFYDELYKDNPEMLRQKMSECSRHRGRRDPARPRTPPGYWQPRWHVPNDTDETKPIPVEPIFKEPTVRKKGEKLALPGWSCDECKQFYDELYKDNPEMLRQKMSECSRHRGRRDPARPRTPPGYWQPRWHVPNDTDEFNRLNNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG05</accession>
    <name>A0A194RG05_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG05"/>
    <dbReference type="FunCoup" id="A0A194RG05">
        <property type="interactions" value="1021"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RG05"/>
    <dbReference type="InParanoid" id="A0A194RG05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="164" mass="18364" checksum="2BF201FDDB5A5F48" modified="2016-10-05" version="1">MRILILGLDGAGKTTILYKLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYGNTDAIIYVVDSADRDRIGISKDELVHMLREEELANAILVVLANKQDMAGCLTVAEVHQALGLDALRDRTFQIFKTSAVRGEGLDQAMDWLSDALQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGR0</accession>
    <name>A0A194RGR0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The L3 protein is a component of the large subunit of cytoplasmic ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGR0"/>
    <dbReference type="FunCoup" id="A0A194RGR0">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGR0"/>
    <dbReference type="InParanoid" id="A0A194RGR0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="399" mass="45460" checksum="2BC0EE68778767C4" modified="2016-10-05" version="1">MGFYPKKRSRRSRGKVKAFPKDDPNKPVHLTAFIGYKAGMTHVVREPDRPGSKINKKEIVEAVTIIETPPMVCVGVVGYIETPHGLRALLTVWAEHMSEDCRRRFYKNWYKCKKKAFTKASKKWQDELGQKSIEKDFKKMIRYCSVIRVIAHTQMKLLKQRQKKAHIMEIQVNGGTIEDKVKWAREHLEKPIPVDSVFAQDEMIDCIGVTKGKGYKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGQGIHTKDGKVIKNNASTEYDLSEKSITPMGGFPHYGEVNNDFVMIKGCCMGPKKRVITLRKSLRVHTKRAALEKINLKFIDTSSKFGHGRFQTPADKAAFMGTLKKDRIREEAAATTTTAAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH66</accession>
    <name>A0A194RH66_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH66"/>
    <dbReference type="STRING" id="76193.A0A194RH66"/>
    <dbReference type="InParanoid" id="A0A194RH66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000369">
        <property type="entry name" value="semaphorin-2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF90">
        <property type="entry name" value="SEMAPHORIN 2B, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="651" mass="73462" checksum="8EDCC5239BE4A100" modified="2016-10-05" version="1">MNEERNTLYVGAMDRIFKLNMTDISQSHCERDALVLEASNVARCVSKGKSEPFECRNHIRVLQPLGDGDRLYVCGTNAHSPKDWVVYLNLTHLPRHEYVPGVGLGVAKCPYDPADNSTAVWVTRGNPGGLPALYAGTNAEFTKADPVIFRNDLFDFRTGQKRFNFKRTLKYDSKWLDKTNFVGSFDVGEYVLLFFRETAVEFMNCGKAVYSRVARVCKQDTGGKHILSQNWATYLKARLNCSIPGEFPFYFDEIQSVYQMPGDTSRFYAAFTTGASDGLVGSAICTYTMEDIQNAFAGRFKEQATSSSAWLPVLRARVPEPRPGTCVNNNEALPDNVLNFIRSHPLMDSAVRQEGDAPAFYKRDLVLTTLVVDKQFVDMLGDDITYTVFYAGTSSGEVYKIVQWAGGGSRVSDVWRAAGTEAVRALALSRRTHALYLATDNRLRQLPLRACTHRYDSCVRCVLDPYCGWDKEAGICRPYTPGLLHDATNSTPSICEASAPLRTVRAGYGQSVHMAAFGKTPEALKDQIVVWYHHSREKGRYKINYNWERILQTSERGLVLLSVTESDRGRYECYFGPTLIASYNLDIDTQRCSQPSRSQEYKQVYSDWCHEFEKYKSAMKAWESRQMQCSKSLNSSSQQNNMDNEIVASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH77</accession>
    <name>A0A194RH77_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Paired mesoderm homeobox protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH77"/>
    <dbReference type="STRING" id="76193.A0A194RH77"/>
    <dbReference type="InParanoid" id="A0A194RH77"/>
    <dbReference type="OMA" id="AKTNNHL"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000182">
        <property type="entry name" value="Paired like homeobox 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="279" mass="30353" checksum="8EE216CCFC848B37" modified="2016-10-05" version="1">MEYGYLGGAGGGFEGSCLAPGSGELAWGELASCGQMSQAAYRYQGMRYQPPPPQCARPQDATIRNHHIFPPSMNLQPGLPYKMYGGNDGSLTEKRKQRRIRTTFTSAQLKELERAFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKQERLAQQKAGEAPVKAEGKRDKPGSPASPQHTPPAPQPTHHTLPHLSPPDLKPITSAANKLCDELNGVGSGGGGMPPVSSASGKWAGGCGLLRQPSGFPLLGVAPPNYLLSDHLGTLAKTNNHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHI1</accession>
    <name>A0A194RHI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional activator cubitus interruptus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHI1"/>
    <dbReference type="STRING" id="76193.A0A194RHI1"/>
    <dbReference type="InParanoid" id="A0A194RHI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115485" checksum="818DEFEA71973B92" modified="2016-10-05" version="1">MQVEQEVVGEVGQLPLMLRAMVAIGEPRTQHAPRFGHKMAAGPRILPHPHDMPSAGIPGRTELGNTNVAVELKTGLPNTRRDSGISSGSSLYSARSSDISRKSSQASVVSGAVSAGGAGAVPRLLHHHNNVYDQLSPDSSRRSSQVSCVGYAPPPSSALAAVQAVCALDRWMDGCLFEDISRKSSQASVVSGAVSAGGTGAVPRLLHHHNNVYDQLSPDSSRRSSQVSCVGYAPPPSSALAAVQAVRTSQGNQAVLLRGVTCSEVRAEELALELEAEVQVKQEARRLSEQSNLSDQHAYQPYPCAADEVGDAPFQFKTENDHEAVTYKESRSNSTNTVVTTAQVHHPNQEVNLEQVAEGEMVENKLVIPDEMMQYLNQSILATDTVTPAKTDPADPEPKDKDQPTKDNAGDTKNINNSSDKISEVATSDDSLLKNLGAIGSDLNISDIPVDLRSLDVSMSGNSGSLLAKTPEDKSTPIQEQVIPEVVKEKCEQDFSQPPNTNASNNPLQSLQTMTANQTEQSNRMRKNNPLPQKTAMSPKTIVMTPQNVLSPSLTHGMLSPQSLPHSAMSPQSGMSPHNIQSGMSPHMPHVMSPPSVYNVMSPQSVMSVMSPQHNAMSPQSMQSLMSPQMPNQMMMSPRHNNIGSPMSQNIASPMMNIASPMSHGMASPMHPGLQSPLTSPMVQNMSNMTMNGTPVPNQTQNVMMSMNQINQNQMSGAPYVNNRQTCNAKMPNKNYSNVPPNQYQNQNYGPVPPYPGQVQNQNMRNQQNMQQQYQMMQYNQNQMPRQGQMVQNQPNMTYNQMMNYQSVNYHNQMQTSRSSAMSTDNSANIRTMNSYCEQLNQMPPQNPYNQNMQYPQPPPYNSIVNAANVMGPPPPKNNHQYNQAMMNNNQYYNHQRPYNQWDYPGNQFNKHNMQKSVQNSVNMSTGSQKPVNGTRVSMNCNQMKSDQQTDCSMNSVRSQNQTSEVQVWDISQSQIEASNGRKKNQNTMRQDTYQRTLEYVESCENWKSSEMVSSSTHPLQADNMVVNDLQTSLSSFYEENQYLQMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIV6</accession>
    <name>A0A194RIV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA:lysophosphatidylglycerol acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIV6"/>
    <dbReference type="STRING" id="76193.A0A194RIV6"/>
    <dbReference type="InParanoid" id="A0A194RIV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14851" checksum="7AA40095A6743F1D" modified="2016-10-05" version="1">MDTEILLNHLSSVLESGDDPAACSNRRTLVLSNHQSTADVPILMAAWNPRPGVLANLMWIMDRVFKFTNFGIVSVLHKDFFIQAEAQVGACLIFPPPDFLVIKDGILSHEKGHEKPDTDNLLQSTELGINSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJV1</accession>
    <name>A0A194RJV1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulation of enolase protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJV1"/>
    <dbReference type="InParanoid" id="A0A194RJV1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="15554" checksum="0DB176023174F657" modified="2016-10-05" version="1">MQVCVEANFEELYDQAGVMIYSDEKHWLKAGIEFNDGQPMIASVLTNELSDWATGIFTGNPGKFWMRITRVDRVICVKYSTDKIAWHLLRLCPYHEVDKYFVGVFSCSPKRENLKVIFRELSFSVPQEDILHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKQ8</accession>
    <name>A0A194RKQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_07312</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RKQ8">
        <property type="interactions" value="1782"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKQ8"/>
    <dbReference type="InParanoid" id="A0A194RKQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006065">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="509"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="732"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1364"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1416"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2040" mass="234501" checksum="18EB403FC8E9AD53" modified="2016-10-05" version="1">MSNRAEAQPKQKIMLELPRITRALRAHTQLDKPKHPLHLFRYSTVGVYNFRKFMTSMHFILLCNQNISLYERYKSYADIYNYVKENEPGSVLKHLDELKESCKLLTGDQPDEIIEDAAVLTLRMFLDHDIVMLKHLSQLRQMFGTVVSTTANKICQIVTNISSNIKEDTKEYIRKEINESNKENIKIWGDHIQCNYIPYKPAKKPLPKLTKKPAVTSSFVTDFSMKYTNDIVKTENRSVEKPLPVSKFGKTWLETKVQGLYNNDGGMSSADILQSIITLLNSPRSNDDMQNDLFELLGFDKFEFIQEILEHRQEIIDSLKAPPVQPTISEIAAMLPENKMPQYLCQVSVLSEQEKMLAKLVRKEEKKAKNVKKVEDEDEHELNIAQLRAKRIAELSKPVVPFSTTKSKIDPILQKISYFQTKVQYPNVYDSSIDAKNSAGFVSGMKLVLPENAIRKDIKEYEEVIIPKNEPAPLQIGNKRVPISELDEIGQMAFENIKELNRIQSVVFQTAYNTNENLLICAPTGAGKTNIALLTVVHQIKQHIENDVIMKNKFKIIYIAPMKALASEMTASFGRRLRGLGISVKELTGDMKLTKTEVQQTQMIVTTPEKWDVVTRKGATDTELASIVKLLIIDEVHLLHGDRGPIVEAIVARTLRQVESTQNMIRIVGLSATLPNYVDVARFLRVNPNIGLFFFDSRFRPVPLEQQFIGVKDIGGGGGSHLRQMQTMNEICYDKAVDMVQKGHQVMVFVHARNATHQTAMILKEIAQKKGHLKHFEPEDTGGFLKAKKSISSSPNKQLGELFAAGFACHHAGMLRSDRNMVEKYFSEGYIKVLVCTSTLAWGVNLPAHAVIIRGTEIYDQNHGTFMDLSILDVLQIFGRAGRPQFDKSGTGIIITTHDKLTHYLKSMTNQFPIESNFINLLADNLNAEVALGTVTNIDEAVEWLSYTYLFVRMRINPQVYGLTYSDVQEEPMLETKRRELITAAAMQLDRTLMLRYNERTGDLNITDLGRTASHYYITCETMEVFNSMVRKSMTQGYVIEMLTRCSDFQQLKVRKEELTELWNLKEQYCELRIEDPPEDIHWKINILLQTYLSRGRVNGSSLQSDLNYICKNAVRIVRALFEITLRKNNAYMAGLYLKMAKMFELQQWDFYNDMRQFNCFPNEILKHIEYPMLKPDQIRDMEWQELGDLLRNPKAARHMKKCADEFPLLEMEATLHPITRTVLRIRLTITPNFRWNDKYHGKAPEAFWIWVEDPDTDIMYYHEYFLITKKQVITREPQELVITIPISEPLPPQYYIRATSERWLGSESVLPLTFQHLILPETHPPHTDLLELQPLPVTALNNPSFEMLYNFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEVAMFRVFNQYPGCKVVYIAPLKALVKERIKDWKVRLEKRLGKNVVELTAYLAAEDNPKQWLHMQESEMEQILSNIRESNLKLTLAFGIGIHHAGLHEKDRTTVEELFVNQKIQVLICTATLAWGVNFPAHLVVIKGTEYFDGKQKRYVDMPITDVLQMMGRAGRPQYDNEGVAVVLVHDQKKNFYKKFLYEPFPVESSLLEVLADHLNAEIVAGTVQTKQDILDYLTWTYFFRRLLKNPSYYNLDSLEPQDVNYYLSNLVHTRLDALLNANCIEIEEDERTIHSTWMGRIASYYYLSHKTMAHFSAHLHANMNADDLLRVLADSEEYATLPVRHNEDILNGELSQQCRLPVDSLTLDSSNVKAFLLLQAHLTRLTLPNTDYLTDTKSVLDQTIRIIQAMIDTSAENGWLSECLSCQVVMQCIVQARWPSDSPLTTLPHVDSQHLYIFSHMTQDTNKPCIMLNGLKVACMRNYELLAKYCRREFEEYQIEQIHRAICDLPTLDIKLKIRGLWFDSDCEQDKRIQQPPGKDSWLPLHAEQEYTLLIDMERRGGNPNNVLCPRFPRGKNEGWFLTLGDTEHGELLALKRVPPRGTAQLTLYTPAMTGRIIYTLYILSDSYLGLDQQYDLQFELMDPLPPETVDTVYDPGEKIITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKT2</accession>
    <name>A0A194RKT2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.4</ecNumber>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="7">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="7"/>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKT2"/>
    <dbReference type="FunCoup" id="A0A194RKT2">
        <property type="interactions" value="1634"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKT2"/>
    <dbReference type="InParanoid" id="A0A194RKT2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="10">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7 8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="337" mass="35491" checksum="7D37925E299FCC10" modified="2016-10-05" version="1">MAVSGRILPWVKDGLRLTSVRYSSCASGSAGKPYEQTRKNLVLTKETRVIVQGFTGKQGTFHSQQALDYGTNIVGGVSPKKAGTEHLGKPVFATVKEAMEKTQAQASVIYVPPPGAAAAILEAVAAEVPLIVCITEGVPQHDMVRVKHALLRQNKSRLVGPNCPGIIAPEKCKIGIMPAAVHKAGCIGVVSRSGTLTYEACHQTTVTGLGQTLCVGIGGDPFNGTDFIDCLEVFLQDPQTKGIILIGEIGGQAEELASEYLTQYNTGQKAKPVVSFIAGLTAPPGRRMGHAGAIVSGGKGGAKDKIKALEKANVIETRSPAKMGVELLKEMKRLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL51</accession>
    <name>A0A194RL51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubulin--tyrosine ligase-like protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL51"/>
    <dbReference type="FunCoup" id="A0A194RL51">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL51"/>
    <dbReference type="KEGG" id="pmac:106721513"/>
    <dbReference type="InParanoid" id="A0A194RL51"/>
    <dbReference type="OrthoDB" id="60477at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="1">
        <location>
            <begin position="71"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="613" mass="72354" checksum="BF32D2F4593B6532" modified="2016-10-05" version="1">MDGISNFNTFLAMHKPQLVSSGVPEHFWHTLCKKLRDQILDSGVAFELMQIDYEDKQKMPYDPIWCIMAISDIDKANSDHIYLVDHAWTFKANSVKRNLRNVPGLLETMCNYMQITSTDTEERIEEVSRNIWRYAHTYAISGSEFSIEDRVPVWYVLDLLGFGIIHSDNPNFRAVPFIYVPHQLTYTLLFPIENVEEGDTITVNFVEGHYPDPKQREAMLIPWKHYEYFDEDFTQEEPDKRYFLEGHIIETLPYVEILQLRQTRSEKLKVFSEYSLINEHLTLADFEIVDNERDADILWLTNHFKNFQEFSVDSPHKFINQFPFEYVITIKDLLAIVARRCCEEGKNIDKDKLETFPTWLPTTFNMKTELPKLVAYYMQRKKKGLDNHWICKPYNLARGLDIYITDNLNFLCRLPLTGPKIAQKYIHNPVLFERPNVGLVKFDIRYVILLKSVNPTEVYIYNNFFLRFSNKAFSLDNFEDYEQHFTVMNYAEGVQLYRMLCADFKDNWAKQYDNFSWDEVEKSIFKMFAELFTAATSKQPPFGIAKSPQSRAVYAADLMLSWDTNKSAMEPKLLEINWMPDCQRACVYYPNFYNDIFSVLFLDKEVETCTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLZ7</accession>
    <name>A0A194RLZ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLZ7"/>
    <dbReference type="STRING" id="76193.A0A194RLZ7"/>
    <dbReference type="InParanoid" id="A0A194RLZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265302" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="110663" checksum="E84CD430838E3323" modified="2016-10-05" version="1">MRSSVKTALCVLLITGFAFTAKASVPRQVTLNAGEKLQTSILTLNDNVVGCYLSNPKGDEIEFKPQNHSNDKYQLLDDTDFVKCQVTVRNLDSNDNGLWVLRSVSDAGTTRTESYQVINLNLNQGTTATASDNITTTEESSKEILTTLTPGELLEETTIAQATEVILDTTTGKDDVTAVDIEHVYIRTKLGETHTLTIPEYDFMNNEKCYLVKPDGEQYDFEDMHISDVEIINDYTVACGIRIFVSREEMLGRWTLISRGTRFSTEVVERRLPFTIFLEAETTSETPIIDTTKSVEVTSKDSTTQKENFDTTIVELPKETTEKSYTTENYIIETTTKKIEDVSIINIDPGYFVTKIGETHKVKIPEYDFLNSNECYIITPGGERHDIEHLQLYGIEAINDYNVACGVKIHIVSEDMVGDWMLVSRATRFSTEIVERRLPFTIVIEEIVNALPSEITIMEGRDIYIRLEDATSFHTTCKLLVGRDEKRVNVERDPRYVDKCGFIVRNATTNDTGFWKISYGIKTIYFAWARVTVYGRSDPSFQTHFTWTLDRPVTQLIGPESTVYCKLVDASHNTVFDGFGRCNVMLSRVSNEHAGTWKMYVGLQGRVLTDEYDVHVSIRKADPKPAVSTSVVTNKPTVTLTCSVASSETLRSCKFRDPAGRILLATPGVGEGRYTFHGNSASSVFGDYRLECGIQITDPVISDLGLWRCAMETDSDNYYGFLAALCPWAMRDPEVAASVRSVLPSSRDVFRAHNGTTFSISPGESTGAAEYAGAGFDAGECSIRFSNLLPTDSGRWSCHVGILDHQEPEQTAQFSLTVRDTLVAEQRMEKGAVIVTGRVYDDRALDYCRFVRIDGLGFTTDNLPTGYRSDSQLSVGRCEIRIPNPSVLERHPWTVAMRVQGMSFEFSKQTNHSLQMPEDGGDDDTIVIYRFPFSWIFIIVIGLSLIIVGILVGPKKNRKWTYTKASTFRERKVASEQTVPEKNTAMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RM69</accession>
    <name>A0A194RM69_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride intracellular channel exc-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RM69"/>
    <dbReference type="FunCoup" id="A0A194RM69">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RM69"/>
    <dbReference type="InParanoid" id="A0A194RM69"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17139" checksum="76CD7D4FED6CD437" modified="2016-10-05" version="1">MDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPPILIDNGLAILENEKIERHIMKSVPGGHNLFVQDKEVASLIENLYSKLKLVLVRKDEQKSAALRAHLGRIDALLERRATRSVTAKALKMKKHEELETPTFTTSIPIDVNDLSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMC2</accession>
    <name>A0A194RMC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enhancer of split mgamma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMC2"/>
    <dbReference type="KEGG" id="pmac:106721057"/>
    <dbReference type="InParanoid" id="A0A194RMC2"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19741">
        <property type="entry name" value="bHLH-O_ESMB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="44337" checksum="19DEC3A82535D517" modified="2016-10-05" version="1">MEPAPLSKTAKYKKITKPLLERKRRARINRCLDELKDLMVGALEIDDDNLSKLEKADILELTVNHLTKLHTPKDPVLEAKKFQAGFGQCAAEACRFIMSVPDLDEKVSQNLISHLSRLITSQPLTIHVPERPPFSPPTSPSSVVSDRHHYYSDHDRSSSDAEDSVYSGDGMKQWSYSRQAKLQPKPYPMAGLLTTVDKLQQPAQEQSSGRNGYFNRVPAEAKDAILQKIRQHIMDKRGNEHSAVVDFNEQPEHRYMPREDAYRAEYDYQMASYPTNNDTLDLRKVKSPVSVSEVAHSRKNLEPRNVNEESPDHSKPNVASLPEHCESPMDYSNLPPKKKRKLIEYQEYKKQEEAKRQLDAFYAEKKDHLRPAPLADDLDVNKWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNJ6</accession>
    <name>A0A194RNJ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNJ6"/>
    <dbReference type="InParanoid" id="A0A194RNJ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="448" mass="52004" checksum="B8914B9553C3EF4D" modified="2016-10-05" version="1">MSNSSDVSRPKRYFGFHYILLRFLGLGWWHHPDENNTRNFPGLYFYYALLTELVWVVIFVGLESIDPFIGHKDLDRFMFSLSFVVTHDLTLIKLYIFFFKNRDLQDIVRTLEINLQDYYQNNGLIRRTIKVTKILTGSFLFFGWLTIGNTTIYGIVRDIKWKTEILQLNESTSKPPRTLPQPIYIPWNYENERPYIVTYLFETIGLLWTGHIVMTIDTFIGSVILHMSCQFTILQEAFLTAYDRAIESIYQGIQTNEYSVSDSSERINTSNNLDMKENSIRMYKSDKEIEEGLLTVLKSCFKQHQLLINCVEKFSVTYSYGFVTQLLSSMAAICAVMVQVSLDASSFKSVRLITSLAFFVAMIIQLAIQCFTGNELTYQARRVADAVMECQWERMPARVRKMLLLTMLRAQKPLHLTAAGFANMNNDCFLSIMKAAYSYYAVLSKRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNK0</accession>
    <name>A0A194RNK0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNK0"/>
    <dbReference type="FunCoup" id="A0A194RNK0">
        <property type="interactions" value="1266"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNK0"/>
    <dbReference type="KEGG" id="pmac:106720769"/>
    <dbReference type="InParanoid" id="A0A194RNK0"/>
    <dbReference type="OMA" id="TWLTGKH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="17705" checksum="74DA73AA5788C719" modified="2016-10-05" version="1">MSLPRVYFDVVADGAVLGRIVVELRTDVTPKTCENFRALCTGEKGFGYKGSTFHRVIPNFMLQGGDFTNHNGTGGKSIYGEKFADENFVLKHTGPGVLSMANAGPNTNGSQFFITTVKTSWLDGRHVVFGNVVEGMDVVKQVEALGSQSGKPSKKVVIADCGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNQ8</accession>
    <name>A0A194RNQ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNQ8"/>
    <dbReference type="InParanoid" id="A0A194RNQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="392" mass="45412" checksum="749B9709119B7CAE" modified="2016-10-05" version="1">MLSDEMLIIQQNLQRKDINQIPSVHISTGNNAPTPTLEVKQKWSVMNFLSNAIALNESQEFTATKRQNKTDIKFQTINNKSQSGDKNKQQCCNNSRDKIVELRSLNDITPDIVTSEYLQHGKICTCMNTNTYTSCNHRCTAPNIQEHSQSHKSNTDHLCSRTITRSQGTQPNIPFYITTEMYNFYTVTPYPIYYQWINDVTKKKSKHRKNKKPPEHLDDVYYDYSEENNSQENTDFNDDNLEKIKYKINPDKDEEKGKSSEEKDVVINVEYKDMETPNSEKNEDGVIDDILEQGEIQVSNKDKFTNQIFSDLKKYYNDVVIKDCSKRANGYMNSPKWQSDRWPQTFAIADALPQSTKEEMHKKEYLTFLCISSSIKSTSPSHPFLIRQGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRI3</accession>
    <name>A0A194RRI3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein 185B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRI3"/>
    <dbReference type="FunCoup" id="A0A194RRI3">
        <property type="interactions" value="1600"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RRI3"/>
    <dbReference type="InParanoid" id="A0A194RRI3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="39282" checksum="789F08211D79DBD9" modified="2016-10-05" version="1">MNLQTLFQDFNPSKFVVHTCLLIFTALLALKLDKTITWSYWAVFTPIWIWKFLVVLGAIVGTYVWWQYPHFRLEGEAYIHYKAMLISLAIHLILLMFELLVCDQLSTSRHLWILVFIPLIFISIVSIAICIWSVKHDRSYELELFCAVNILQFIFLALKLDTFIHWSWEVVFVPLWILMCLSLVDFLFCPIYHQNLIELMRSLITLLVLLTNKLDNRDELSSFSYIVVVSPLFISYATLIVMSFSSKGGNKWWFGIRKDFCQFLLSVFPLLQEYANIAYNNNVNRSSMPSEPVTQEPYRDEEIHKKVKDKKSQKNQKKNEAMKPVVPVTSIDMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS93</accession>
    <name>A0A194RS93_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RS93"/>
    <dbReference type="STRING" id="76193.A0A194RS93"/>
    <dbReference type="KEGG" id="pmac:106721305"/>
    <dbReference type="InParanoid" id="A0A194RS93"/>
    <dbReference type="OrthoDB" id="5597713at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265398" evidence="4">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="413" mass="44808" checksum="C7C356F97820B920" modified="2016-10-05" version="1">MLVKTAILLIALAINLASAEFIKPDFIENVNKKSDDSRIVSGWEANPGQHPHHASLRMVFRLGIVNACGGSIVHRNWLITAAHCTAGAVTLVVRAGVTDLTRPEYISETTEWYNHPSYNDLLPTQVQPNDISIAHLPNPVTYSANLRAIRIQPAADAYRDYEGEVLYASGHGRTWTEGTSPEVLNWVYLRGVSNPSCASTFGSIITSTTICARFFNVTSQSICQGDSGGPLVHRGSDDVPTLIGVSSFVAQVPWGCHSGLPGGFARPGPFHSWFTEVTQIDFDNLIEEDPPTTTTTTTTTTTTTTSTTPAPTTTTTTTTLAPTTTTTSAPTTTTTTTVTTPSPPPNTTTSAPTTTTSPTEESEEEDSDSESEEDPELAELAKKLEVKVKVKVKLQKNQKKYKHQHEHEHKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAW8</accession>
    <name>A0A0N0PAW8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAW8"/>
    <dbReference type="InParanoid" id="A0A0N0PAW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="10851" checksum="229CAF65F1E0546B" modified="2015-12-09" version="1">MAGTLSEYVNERHTAPWKVRFYPKKSLFKKSELIDRGCNVFLTDCPSNYKKKLVCGRHYDGELRTFTNYCALEFENCNSWRKWSLIKETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB06</accession>
    <name>A0A0N0PB06_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_03422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB06"/>
    <dbReference type="STRING" id="76193.A0A0N0PB06"/>
    <dbReference type="InParanoid" id="A0A0N0PB06"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ09818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="22588" checksum="6BE211756B29C809" modified="2015-12-09" version="1">MTGESLEELAVRLFDAGAVRLGDIEAKLGRRTPIYFDLRVIVSHPKLMMAICRQLQNLAKEIPHDILCGVPYAALPFAAVMSVNTNTPMIMKRKETKLYATKKILEGVFEKDQKCLIVEDVVTSGGSLLEAVTTIRAEGLQVSHAVVVLDREQGGASVLKANGVQVKSVYTMTNLVKILRNAGRISDETAEIVSDHIKECQFGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB91</accession>
    <name>A0A0N0PB91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB91"/>
    <dbReference type="InParanoid" id="A0A0N0PB91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="7547" checksum="933B7F5955A00D00" modified="2015-12-09" version="1">MCGACAVTRHASLASAAELTTPREKLPAAMPLTESEAMRSSAGDERGSEGNSDADAALDPPVSGASVSSSPPNDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBP2</accession>
    <name>A0A0N0PBP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460874">
        <property type="protein sequence ID" value="KPJ11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBP2"/>
    <dbReference type="InParanoid" id="A0A0N0PBP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="40940" checksum="B9266B59C30D5712" modified="2015-12-09" version="1" fragment="single">RLAWYGHVMRKKESHVAKRTLSMNVEVQRKWLWCVFILYSGPTWSPVRCVTVRTPPKNPTTVEAQAKFFQDFFSVQLSPYKIEFGHVCEDPNTWEQRYEKKDYKNHRDMGKVRWGDKKGGYGEHYWDLNHAGHAGDHGDEGYDSPDDSSYHEDRHEPYEEPSEQVHKYDEDGYGPEYPSKYDEPNRAKRANIKRNVKKARGEQDRQKAQEKTKTEESTELKPVDEYEAEASEEKEIFEMNTKPKSQRIEKERKSEESIPKPREKNQVVLILSQKERNTPETGEQMPRTKEEAKHYVPYEGGAGVRQHQYPEVIRTTVPRLFLEPSTGHVVDRATGQAYVLQPLVQKPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBT7</accession>
    <name>A0A0N0PBT7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460786">
        <property type="protein sequence ID" value="KPJ12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBT7"/>
    <dbReference type="InParanoid" id="A0A0N0PBT7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="174" mass="19053" checksum="5134E5018BFA5039" modified="2015-12-09" version="1">MQLNEQSWTQASLPIRFGGLGIRKISSVALPAFLSSVHSSANLISKILRAPPSNFEIAGLEEARNAFLIACPGQNFPVSPKSQRSWDDLNCKLTYDNLLSCSTDSARARLLASTEAGSDVNGCDIMVGISESFGMLEDLIGGGSEWQRLLQRVSQTQRQLQVLLHVCQRLMCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC02</accession>
    <name>A0A0N0PC02_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460734">
        <property type="protein sequence ID" value="KPJ12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC02"/>
    <dbReference type="FunCoup" id="A0A0N0PC02">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PC02"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="255" mass="28695" checksum="7502F74B526FE5C6" modified="2015-12-09" version="1" fragment="single">DEIKRERDFYRAKGLPCPKDAALAADKPGAGDEPEQPDNTDCHRKDEQVNLFVNLVFEYWVRTLEMKGWLRRTPGKETLIFMLGSAVFFYLMRKDRENRKRTPLFWFFTPPRVSKEVGEPIKGISGRSPACPHKGNCSNYILRGTIQLFGVGCAMTILRTIIPRILTPTKALKSLRLSHLKLGLFFGGYIGIYRLVVCLLCRAYGKDNALYAIPAGFLAGAAFRASPSLPISLAPLTSTLQVCSFYRENSMSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC69</accession>
    <name>A0A0N0PC69_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scolexin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC69"/>
    <dbReference type="InParanoid" id="A0A0N0PC69"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857362" evidence="5">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="261" mass="28658" checksum="6C4B838C22AD14E1" modified="2015-12-09" version="1">MARRERSLLYVAAVCACACVVSARPDHNNPHPVQKLETKISRNNSIISSPGSDIFEQILLNTLFTGGKYVLAGTNNSEDGSGVSRRVKQLYVHPRFAVGPYWLNAKRYNIKQVAARFDYLLAELEEPLELNGVTIAAAELNELQDLPAGINVGYAGYGAEHHGETMRHEMHGMDLSLLAEEECARLEEYDSQDMICIRGRAPRYDSACNGDSGSGIVDENGVLIGIASWVENDALECRNGATVYCSKVATARPWIRKITGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC99</accession>
    <name>A0A0N0PC99_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC99"/>
    <dbReference type="InParanoid" id="A0A0N0PC99"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="6206" checksum="77BFAC7EF96DBD98" modified="2015-12-09" version="1">MRACGAFGQLGSILGTVTMFLLVNFTNLFTQAPAPDCPGAHAHYGDALHAYTPSLLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCA9</accession>
    <name>A0A0N0PCA9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460648">
        <property type="protein sequence ID" value="KPJ13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCA9"/>
    <dbReference type="InParanoid" id="A0A0N0PCA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="236" mass="26995" checksum="5FED9AA8AF759C7A" modified="2015-12-09" version="1">MRRRNRGGLAGNDLVKKWKAIKDNFAKYQKKLKDANRSGAGAAKIKEYHLNKQLQFLKKVSQNATDSSLCVAEGDIENEITALPRYKSQPRKRKADDKDDIEEDLLAILKTPENRHLHFFKGILPSLQSLNENQTLIFQSRVLQILTDILQPSIHQNTHHGYNQEYQHQGYNQGYSTMRYDNTVQSGYHTSTPGSSITEQRTTSSSNQQRPINSPFLLDETSATSYVSQDEEFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCP5</accession>
    <name>A0A0N0PCP5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCP5"/>
    <dbReference type="InParanoid" id="A0A0N0PCP5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="201"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="606" mass="70154" checksum="A0029EEF2D334C3E" modified="2015-12-09" version="1">MVRGGGFDGGGDAKEDEQYHQLPELFQLDDYEACLSQRRGAFCLATFDLLPSSNKQLFNIIQQFSEDRANFNHTRIHRGYCVSARCSHIDEVSLNRRFVKCVSDITKNTYGLDTKLATLDYCKTTKRPPTKPIDELDIAFAYVSGFILLMNVIGTIYDLTRNPDHKPNRYLMTFSFMDNWRRLTDSYENGDARLNALQPIHGMKAITLMCVMLAHSVIIYHSTYLMNPRFIENGNRHPLSILLHNGTVIVQTFILLSSFLFAYNMLIYIENNPKKQLNLSLFLSSVLNRLSRILPLYMFVVGFVTTWWRHTSDGPFWSPLVEAECARCRDKWWSQFLFLNNFYKPDDKCLVQTWFLAVDLQLYVLAVFLTLILGQSFRTAIKVLAGLLIFSMATNFAIAYYGDLKSVLFVTNTEAIRSLYYGVPSFKWIYMAPWTSLPSSLLGLIAAFLLYHWQKNNYDPKESLICRVLYRCSVPILLISVVSGYFIRYTQSPLVTSIYTAIDRPLFCLMMVVALLGFIYKIDSLWWQFLSWSGWRPLSRMSLSILLIHWCYNLTQAAVKTDLARTSVYEIGGHWFVTMFMTYVTSLPVYLLVELPLQRFLKAMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDQ2</accession>
    <name>A0A0N0PDQ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysine-specific demethylase lid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDQ2"/>
    <dbReference type="STRING" id="76193.A0A0N0PDQ2"/>
    <dbReference type="InParanoid" id="A0A0N0PDQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lysine-specific demethylase-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="232" mass="26735" checksum="0F342CB8EF0C7AC7" modified="2015-12-09" version="1">MCRYRYTLDELPAMLDKLKKKSELFREWAEAVQNALDPDTPKTCDLDGLRAHLRRAHELKMHKTELVRALETAIEDAEKCASVIQQLDLNKMRTRTRHHDPKYRLTIHELTLFAAEIDGLACVLPEDRLRNLKTERRSCSARNLDEVDATTVRELEEVVELGSRLCIVLPQLSGAQGRLAQARWLAEVRTLREDCAALTPPVLDRLLRDADNVLPHRRVEQERAALYKLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDY1</accession>
    <name>A0A0N0PDY1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptotagmin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDY1"/>
    <dbReference type="FunCoup" id="A0A0N0PDY1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDY1"/>
    <dbReference type="InParanoid" id="A0A0N0PDY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08386">
        <property type="entry name" value="C2A_Synaptotagmin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08405">
        <property type="entry name" value="C2B_Synaptotagmin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000159">
        <property type="entry name" value="Synaptotagmin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000140">
        <property type="entry name" value="synaptotagmin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037732">
        <property type="entry name" value="C2A_Synaptotagmin-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037741">
        <property type="entry name" value="C2B_Synaptotagmin-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF344">
        <property type="entry name" value="SYNAPTOTAGMIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="153"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="34051" checksum="02D6F4E01BF09405" modified="2015-12-09" version="1">MAFLQNRSISLVDMYIDNSEPSENVGQIHFSLEYDFQNTTLILKIIQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFSEKPSFWKALKPPAKDKCGELLTSLCYHPSNSVLTLTLLKARNLKAKDINGKSDPYVKVWLQFGDKRIEKRKTAIFKCTLNPVFNDSFSFNVPWEKIRECSLDVQVMDFDNIGRNELIGRILLAGKNGSGATETKHWQDMITKPRQTIVQWHRLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEG2</accession>
    <name>A0A0N0PEG2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein deadpan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_04095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEG2"/>
    <dbReference type="STRING" id="76193.A0A0N0PEG2"/>
    <dbReference type="InParanoid" id="A0A0N0PEG2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="378" mass="42016" checksum="F49B8308A007AF84" modified="2015-12-09" version="1">MPCSEDDDSQTGFMSEPSQGMSKAELRKPARHSKLEKADILEMTVKHLQRLQRQQLAAAIAADPAVLHRFKSGFGDCALEVRRYLSRLASVPTGLRYRLGDHLNSCLSGIERLHPADYPPLVPDPLRLDDERPSAFHFVKSTKPTSPPLSPLSCDSACDSSTELETPPRPVKKFPFPTPPSRSASDQDSSPEQKPTVSSTTISPESLQQEGSRTKKFMEPLSIVIDVENYKIGIDASPKRAVDYSIRQKLKRPSETIGPVPKLIRLEPERKVPSPERAQVDRIVVLDRPEKISAFRRIPTAHERKLTLPVSIPAVVERPSLVLNPVQRSVISHTAESLAQSSTSRAVKQETKETSESSNRPKSPEQGSSSSTEMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF56</accession>
    <name>A0A0N0PF56_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LADJ01003053">
        <property type="protein sequence ID" value="KPJ20864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF56"/>
    <dbReference type="STRING" id="76193.A0A0N0PF56"/>
    <dbReference type="InParanoid" id="A0A0N0PF56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15778" checksum="E7034F4400349D70" modified="2015-12-09" version="1" fragment="single">TCSKCGVRRKCLKWFTVQKFPQVLVLHLKRFSPTERFRGKLSVCVEFPLSGLDMSPFAACRSAQPVYNLYAVSNHSGQSHLTHTHTHTHMYMHTHTYTYTHEHVHACIRRRTNTHKKTTSNVTFKRANSVLASHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFI1</accession>
    <name>A0A0N0PFI1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger SWIM domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034329">
        <property type="protein sequence ID" value="KPJ21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFI1"/>
    <dbReference type="InParanoid" id="A0A0N0PFI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="13452" checksum="4A30B2BEDC688CBE" modified="2015-12-09" version="1">MCAGAARGTPARLRAALAAAQRHVRSAAQLFRLAQDALRHAAPPDAPHHHRDLLAAAFELGLQVLRMTLSSVNWRRREMVRWLVTCATELGLDALLSIMQNWSANHTLSMFCPNLNFQTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFT3</accession>
    <name>A0A0N0PFT3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01060517">
        <property type="protein sequence ID" value="KPJ21614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFT3"/>
    <dbReference type="STRING" id="76193.A0A0N0PFT3"/>
    <dbReference type="InParanoid" id="A0A0N0PFT3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="19316" checksum="A29D819E91889D28" modified="2015-12-09" version="1">MCEVKPHLAVVDYGLSVLEAACPVEWRAARRRLCCVALGPRGVALEELRALAREAPDRLRYAYVYTHAQPDFVRALANGSGIDISEMEHRIVVIWRREPTRIQYEWLNETWPTCTSDGYESAHYQQRLNDTKRALDNLIKRLLKPTEMMAYETHVQVYDVFPFITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG73</accession>
    <name>A0A0N0PG73_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_00765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01067081">
        <property type="protein sequence ID" value="KPJ21692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG73"/>
    <dbReference type="STRING" id="76193.A0A0N0PG73"/>
    <dbReference type="InParanoid" id="A0A0N0PG73"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857555" description="Lipase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="370" mass="41641" checksum="D8045C866269290A" modified="2015-12-09" version="1">MSGRILLLLVVGVTTVSAESLQSDYIDELVRTERYSQRFSNDVKEDAKLDVPELIIKYKYPLEVHEVTTPDGYILQMHRIPHGRDKNNVPGTKRPVVFLMHGLLCSSADWIISGPGSAFGYILVEEGFDVWMGNARGNYYSRNHVELNPDNTDFWDFSWDEIGNIDLPIMIDYALAVTGNEKIHYVGHSQGSTAFLVLCSLRPEYNDKIISMHAFSPVAFMAHNESPVLNAIAPFANSIKILASLIGIGEILPNTLLLTWAGQIFCKDHAITQEICSNILFAVGGWNDAHLNTIIERHITTVKPIFFYYSDNDPLSQSKDVYRLYEELGSESKVLLPLPSFGHLDYLWGIDVKPLLYDTVIQLMGVVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I700</accession>
    <name>A0A0N1I700_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461111">
        <property type="protein sequence ID" value="KPJ08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I700"/>
    <dbReference type="KEGG" id="pmac:106717368"/>
    <dbReference type="InParanoid" id="A0A0N1I700"/>
    <dbReference type="OMA" id="VWGWYTA"/>
    <dbReference type="OrthoDB" id="7430068at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="20918" checksum="E1193FD304571E4B" modified="2015-12-09" version="1">MGQEDDVHSAIAHVVLSCVAARGTTYRYNSYTHPGMHVNLFVHGVVGFLHYQSGKFNNDFGPAYLLSYKASKYLPLPCLMADLYRGNSAMCSLHLASGLLPFTLAITQQDNPELGNLLIACNIVSLCYYSFEHGYVWGWYTAGAAIFAYFLAPQMVQPHKVIYPLGLALMEYCAYRMFSVRIDNPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8P4</accession>
    <name>A0A0N1I8P4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I8P4">
        <property type="interactions" value="1474"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8P4"/>
    <dbReference type="InParanoid" id="A0A0N1I8P4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="9">
        <location>
            <begin position="769"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="10">
        <location>
            <begin position="1777"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1895"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2142" mass="234150" checksum="6124CF7962DC9760" modified="2015-12-09" version="1">MIAASEPLEFVPHGRTVLAKHPGQIYGKGLNNSSSENSLMYKLANFAIKDESLLESKDSGEEWWCIREIYYRETVDIDEDETQQSTKEKYEDSFRPPSRIKPEFNISIKSELLSGIKRTEAEAGTSQGGSANSSSNMSKKFNLNSSQNKQPITKPLNPKTDCCYEEELYVKGCTAVWSKGLISTPGTKLSGPEQRETIACYTIENPIKHAAFCNFHIGINNTMLLDALNSQIGDVKKNIKIEDTTEHIETNIMPSILLMDSKCMRVYAVDGREYITSIPFQVKKVWPTKYGVLLEKEPLPQLNNSLLPISFLKFNESCNSSLYKSKANVPFNMSAKLRAESLVGYDQEYPLPTCFSLSHPLDEVIPILIKSPSQGLQYYSDGDVQIIFVSVNPSIILLYDWKLGYHSLWKIRKATREECLNMCPNINSTTTVFSQSCDFVGSPMQSMVKNTTSWNAGSPFQSKKGMNTPNRSRQNSPMAHIFHQQGLSPHASIGQASSTSMLANSITQTPPSLPLYPDICLDHIWTDSQVIRRDQVESPTDIKTFLHTDLVGHDYLCFLVKVGGTNKLQILRLQRSHSHGQLLKSNLIVGAVSSVYAKDAVVLNDLKMIALIDESGNIILQSGNSVVGKHTRWCCPVLQSPFPRRSSLLPSRSDCAFDDSALHLLSPVPHSSVSRIEHKESLGLRGLCDAAGRRLTLCLENGVLYRIALPPLAAAALPPRAAHALRALLPRDIAMQVLIKWYGVRNAPGTQDLTPEQEWSMFSKLLLTMIGYDVERLGQMRQSDEDGTEVASKKQRTSSDGTQDDWDYLLNSRMHKAIGSSLACMLNLSPTQPESKHWRGKTKTIENDKPVQFNTNSLLFPYMLQVFYAFHLLYEDLKLNVLLSSNLKPLSSFLYQLAKDLRLNNYVNHYWLDFPNDYHYEYMEKESQVTDVMLKKLSPPNYFSPEPPGIFSYLNSMLKNCDVGYYPYLPEVNDTCRDLIEILSTVGCGSGAGVQPLSQQVLGSSTPRPRRDSGPAPAPHAQAALLAADRGTHTHTHTQPLSQQVLGSSTPRPRRDSGPAPAPHAQAALLAADRGITLRGIDNFPPAIGLMLLSIFNRSKSTPPTDWPPQAYCLVMREDLAALTHTAAAMTDTHEYLETLALEALEKETAYSVVTKGTEEGGGGGAAGAAREEEATGMEHLNTKLLALLYPRDHRMTEVFRLLQSSIPATINLTQRPEVSDHDFIEEQEKYLYAITTRTTALPVARGMVTLRSVPAGATEPARAARLCVSGRGPPPRCHAITLSDAAPAALLWPSFHNGAAAGLALVPVAGRTIHHSWIVYNKPRGTQDMSAEHAGFLLALGLNGHLRDMPYMNMFDYFVKCNEMISIGLLLGLAATYKGTMDVQATKMMSIHLEALLPPTSIELDIQQNILVAALLGVGLLYQATAHAHYAQVLLNEIGKPPGPELENCVEREGYALAAGLALGLVCVGAGDSAPPHLAPRLRAYVLGGDRHTYGREGGGVGVSCAAGGGANVDVTSPGATLALGLLYLRAGQCAPAVWLAPPTTPYLLDFVRPDLLMLRVIARGLILWDSIEASEEWVEEQVPATIRPYCFVKPSDDNIDYEAMNQAYCNIISGACFALGLRFAGSGDEDALEAVLSSARRLLGAPGRRLAHLAGAATIETCLCVCLLAAGMIMSGRGDLRVLRLCRRLRARIAVRGPQASSAQPHALSHGAQMAVHCTVGLLFLAGGRGTLSTSRTAVAALLIAFFPKFPTHSEDNRYHLQAFRNLYVLAVEPRLLLPRDLDTGKLCYAHLQVVDLQGVVKKMKAPCIIPELDGLKEVKIDDPRYWPIVFRRDQNWDQLKKFLNFTWCIDIKQRAGCLSYVSDPHGFLTILAHTLTLDKTNMWLATPDNIDLFTNDDKVRSFVKHHLQGEPAPGAGGGAGGGPGGVAGAAGGGACADCLVALRRRGAARGEGVTRTCRCRRYSREEEQHAQALSMLTYECLVKDSLCALPVWATFLKIIKTMRTEPTSYDVWQVRLLVSLAEQQGAAAAAEMRVDGDEALAEPLVSAELALALKQRVAALLDDWQPRLAPALRRYAGVGGASGAGRRAGDETRHALAAYVLYHGVRAGQCGAGRARAAALACAPSPPAAAVAALAPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8W8</accession>
    <name>A0A0N1I8W8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LAG1 longevity assurance-like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8W8"/>
    <dbReference type="STRING" id="76193.A0A0N1I8W8"/>
    <dbReference type="InParanoid" id="A0A0N1I8W8"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="36566" checksum="9ABF1BC6D05CCE98" modified="2015-12-09" version="1">MLRYLLDKFWDKDIWLPPNTTWEDLAPGPDKPVVLNDHRHLLYPIPLAIVLIIIRHMLEKYWFAPFGKSLGIKNTRPKKAPSNPKLEAAYQASTKIRHKQGITNDIWWYYMISTAFYWSLTISQFWDVKRKDFWQMFVHHITTIALLSFSWVCNAHRIGTLVLLVHDCADILLDAAKATKYANYQKLCDMLFAVFTLLWIVTRLWIFPFYIIWSTSIRAPMLQPMFPAYYIFNSLLCLILGLHLVWTWLILQVAYKAITAGKLDGDIRSSSSELSDSSHQSNHSTPNRAHAHANSNAHAHTNSKAHAHVNHNKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID82</accession>
    <name>A0A0N1ID82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459655">
        <property type="protein sequence ID" value="KPJ20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID82"/>
    <dbReference type="STRING" id="76193.A0A0N1ID82"/>
    <dbReference type="InParanoid" id="A0A0N1ID82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="364" mass="41344" checksum="C3308B3883298107" modified="2015-12-09" version="1">MDFGFTGIWQWRSALDFVYVYKLYTPLDGFEENGLVLKNVFGVNTGGGLDTELSMRLSKHKFGIAILLVDKGKGLLDVVKDRFQHKPSDPDMFVENFDTTANVVLDTLYYPTITFHAHMMKTYTEMRNTLNLVTPFQAIKELKSVYTVDITIGEKFNVTCVALLYNGTYWHEISYKILYEYECGEDDAYQSYLASVGIATPLAVLPGLEARVSARLEDALWKMAADISMPSFTVNALARLELDDPFIETSGSLNLTSTYLEDYFIKMEFKKDFSDVESVDMPQVQGKEMFLKSRVDAYPGLRRVLSVQAATPLRKLSFLKGDTDFEFGPKTGYLLCKYELPDMKGDGDLKWSFLIGDLYITVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE28</accession>
    <name>A0A0N1IE28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01020748">
        <property type="protein sequence ID" value="KPJ21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE28"/>
    <dbReference type="STRING" id="76193.A0A0N1IE28"/>
    <dbReference type="InParanoid" id="A0A0N1IE28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7631" checksum="69EFA94B9862F82C" modified="2015-12-09" version="1">MVEASPRRIFANAHTYHINSISLNSDQETYLSADDLRINLWHLEITDQSFNIVDIKPANMEELTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGH6</accession>
    <name>A0A0N1IGH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Spectrin beta chain, brain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_03888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460813">
        <property type="protein sequence ID" value="KPJ12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IGH6">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGH6"/>
    <dbReference type="InParanoid" id="A0A0N1IGH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="169"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="2615"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2482"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="919"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1498"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1558"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1885"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2076"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2520"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2558"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2575"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2605"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2622"/>
            <end position="2632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2765" mass="317792" checksum="8B8E41BD445CC2DE" modified="2015-12-09" version="1">MTTDISVSRWDPSIGHGQEIIDEFEYDGGNSSSRLYERSRIKALADERENVQKKTFQKWVNSHLVRVGCRIGDLYVDMRDGKMLIRLLEVLSGERLPRPTKGKMRIHCLENVDKALQFLREQRVHLENMGSHDIVDGNPRLNLGLIWTIILRFQIQDITIEETDNKETKSAKDALLLWCQMKTAGYNNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLHRNNPMHNLNNAFNVAEEKLGLTKLLDAEDIAVDHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMIMEYESLTSDLLQWIERTIEALGDRTFANSLEGVRQQLIQFANYRTVEKPPKFVEKGNLEVLLFTLQSRMRAANQRPYTPREGRMIHDINRAWERLEKAEHERELALREELIRQEKLEQLAARFNRKAQMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCSELQAERYHDIERVCARRDNVLRLWAYLLELLRARRARLELSLQLQQNFQEMLYILDSMEEIKMRLLTDDYGKHLMGVEDLLQKHALVEADINVLGERVKVVVGQSQRFLEQEEGGYRPLYLLISKHKALQADVSAHEAQLMSVAAVGDELVSQGHFGADRIQERLRDILSQWNHLLDVVALRKNRLDAAVRYHQLFADADDIDTWMLDTLRLVSSEDTGVDEAQVQSLLKKHKDVTDELKNYANVIQQLKQQASELSPEDASSAEVSARLAAIDARHGELAALARLRKQRLLDALSLFKLLAEADAADQWIAEKDRMLDTVLPPKDIDDVEIMKHRYDGFDKEMNANASRVAVVNQLARQLIHVEHPQAPRIQERQAALNHAWSTLREKAEAKKDELKAAQGVQTFHIECRETVSWIEDKKRILQQTDNLEMDLNGVMTLQRRLSGMERDLAAIQARIASLEAEASAIEGTHPEEAQLIRDRIAHINDNWEQLTHMLKERDSKLEEAGDLHRFLRSVDHFQAWLTKTQTDVASKDIPSSLSEAEKLLSQHQTIKEEIDNYKDEYAKMMEYGEKITAEPSTQDDPQYMFLRERLKALREGWAELQQMWENRQQLLAQSLELQLLQRDARQAEVLLAHQEHRLAKTEPPTNLEQAENMIKEHEAFLTTMEANDDKINSVVQFANRLVEERHFDADKIQRKAENIDARRSANREKALQQMEKLQDQLQLHQFLQDCDELGEWVQEKNLTAQDDTYRSAKTIHSKWTRHQAFEAEIAANKERLFAVQNAAEELMKQKPEFVEVISPKMHELQDQFENLQTSTKEKGERLFDANREVLLHQTCDDIDSWMNELEKQIENTDTGTDLTSVNILMQKQQMIETQMAVKAKQVTELETQAEYLQKTVPDKMEEIKEKKKTVEQRFEQLKAPLLERQRQLAKKKEAFQFRRDVEDEKLWIHEKMPLAMNSDFGHSLFNVQMLQKKNQSLKTETDNHEPRILTVISNGQKLIDEEHEASPEFKQLIDELTARWQELKDAIENRKNNLSQWEKAQQYLFDANEAEAWMSEQELYMMVEDRGKDEISAQNLMKKHEILEQAVDDYAQTIRQLGETVRQLTSEEHPLSEQISVKQSQVDKLYAGLKDLAGERRAKLDEALRLFQLSREVDDLEQWITERELVASSQELGQDYDHVTLLWERFKEFARETQAVGSERVATAERIADQMIAMGHSDNATIAQWKEGLKETWQDLLELIETRMPSVFVFNLAMLAASRELHKYFHDCKDTLQRVSEKARGVSDELGRDAISVGALQRKHHNFMQDLSTLQQQVEAISSECSRLGASYAGDKALEITRREAEVREAWAALQAACAARRAKLEDADDLYRFLSQVRTLALWMDDVVRQMNTGEKPRDVSGVELLMNNHQSLKAEIETREDNFAACISLGRELLGRQHYASADIKDKLQQLNNQRNALLRRWEERWENLQLILEVSDELGRDAISVGALQRKHHNFMQDLSTLQQQVEAISSECSRLGASYAGDKALEITRREAEVREAWAALQAACAARRAKLEDADDLYRFLSQVRTLALWMDDVVRQMNTGEKPRDVSGVELLMNNHQSLKAEIETREDNFAACISLGRELLGRQHYASADIKDKLQQLNNQRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLMSQELGHTIDEVESLIKKHEAFEKSAAAQEDRFSALQRLTTLELKGATLWPIARPWDKCDESTFLYQPPSISHKNTQQTLEVTPTNIRPVGDVVEDIIRNTGKYQISEKLKLKLHVNYQNNEASKNDSFLWSVVTNNSLSTISEISSPPMTPLKSPLSPEIYSSVFFEYPFTYEKPDIRLSCIDFILWERLSYQLVYPNVSLIRHNSTVSSKSGSIKRIISKISKKIRLSDDSDKSEIAVLSLPGLSSHSKTVNDLPREVKHIPLSSSLLLLFQTRKLLFPEGAWYYNYLDCFEVKEMKRRQEAAEAAERERVEREAAAAAEAARAELEAQQRASETVDAPQPHDASSPAPEPEAPPSPTSTPSPPPAQDLPRPSTSKPTPAKPARLSTGGSSSTPATPSTSGKTKTRSRSKSPFRSFRWRTAKKLLAGAHHSDDEEGASPAGEDEGFEGTLMRKHEWESGTKRASNRSWDKVYAVAKDGRMSFYKDQKSFRATPEQTWRGEPPLDLTGAVVEVAANYTKKKHVFRLRLGSGAEFLLQAHDEAEMSAWLGALSARLAAPTPRSHTLPAPSAEPKRRSFFTLKKKSVQTLTFFYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IH24</accession>
    <name>A0A0N1IH24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin I2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ15998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IH24"/>
    <dbReference type="FunCoup" id="A0A0N1IH24">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IH24"/>
    <dbReference type="InParanoid" id="A0A0N1IH24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF292">
        <property type="entry name" value="SERPIN 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="60"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="530" mass="59994" checksum="49C516344238767E" modified="2015-12-09" version="1">MCQRINAIIVQIPEDRKMRQLLLVLCLAVGLSNALWLRQGRSDQPKDTRFIGEATNELSTTIFQGYIDDSNNLAFSPLGYAAILAILAEGAKGETKNQLVSALHLPENPNLTRTTFRYIMERLKNTNEYKYNQPELKNFFYIYKNYTINEDYKKILEDYYLTEVRSVERYHSELNKSDDDSEVSETKEDNETKDEISEPLALKDPEEKYITFAMEDKPEKVDISHVGYKPAKNIKEKIKLVKAYSKKEKEESEDEEETMVAVEARNSARSLKILHDKNDISSIVSVNSVGKKSGKPSKSNSLMIIFNGMYFRGSWKQPFEVVEPGVFYKSNTVKKQVPMMKTTGTFKTSSLPDLDSEALMLPYDGGRYALLVVVPRSRDGLTRLIADLPSVPIADIQETMIDEELQVSLPSFYVETTTKPVAALAKFGVSNIFSREAELSGVSEDEGLFVQELVQHVAVRVDNANSAANELSAANPGIESLKNAPFYEERSPRRFCVEHPFIFYIMDRLDNLVVVAGKVTDPQQPTTFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHD1</accession>
    <name>A0A0N1IHD1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459627">
        <property type="protein sequence ID" value="KPJ20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHD1"/>
    <dbReference type="InParanoid" id="A0A0N1IHD1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9549" checksum="933BD028FAF27988" modified="2015-12-09" version="1">MASTVCVSRCRLLAKLEINRGLWLSSIFRDLSNSRESWCRRWRPTRRSIFTSACAHGSKNAPTKLEPEISEGKVTLDNEMQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHX0</accession>
    <name>A0A0N1IHX0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="LADJ01023771">
        <property type="protein sequence ID" value="KPJ21108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHX0"/>
    <dbReference type="STRING" id="76193.A0A0N1IHX0"/>
    <dbReference type="InParanoid" id="A0A0N1IHX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ21108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="18752" checksum="7399169398B151B4" modified="2015-12-09" version="1">MLLVYMSEDSDHVESVELLISYDITKGIIFDILPFNDRVETFELQGRYVREALERSVSEAWDLTPFKGPWLLQVSGLNVTYNISLPEGHRIVSVDIGSSGATLDDDKYYQVTAPTYLADGGDGFTMFKTGKKNVKIIGRDEKILEIYIKKNSPIDVRTDGRIVILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II68</accession>
    <name>A0A0N1II68_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_04645</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II68"/>
    <dbReference type="FunCoup" id="A0A0N1II68">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1II68"/>
    <dbReference type="InParanoid" id="A0A0N1II68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ19214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="562" mass="60553" checksum="CA2DB9E7F51EC6EC" modified="2015-12-09" version="1" fragment="single">GSTRESGVVWRGCSGGCDAEDGAAGALADGNLNPGDKLEGSGAAPDDPVHLKRRVGLFSGVALIVGTMIGSGIFVAPSGLLEYTDSVGISFIIWMACGLLSLLGALAYAELGTMNTSSGAEYAYFMDALYYVRLVVRTNQSMLSSGHNLQYTPSALAYAELGTMNTSSGAEYAYFMDAFGGPPAFLFSWVSTLVLKPSQMAIICLSFAKYAVEPFVAECEPPDALVKLVAVICIVMILAVNCYSVNLATNVQNIFTAAKLVAVLIIVCGGAYKLGLGNTRHLQEPNFASSKATLGNIAIAFYNGLWAYDGWNNLNYVTEEIKNPSKNLPLSIIIGIPLVTLCYALMNVSYLAVMSVSEMTSSEAVAVTFGNRVLGPLAWLMPLAVTISTFGSANGTLFVAGRLCFAASREGHLLDILSYVHVRRFTPAPGLIFHSLIAVAMVLYGTIDSLIEFFSFTAWIFYGGAMLALIVMRYTKPHAPRPYKVPVIIPYIVLLVSAYLVVGPVINKPQWEYLYATAFILTGLLVYVPFVKWSYSLPFMDKITVFLQMVLEVVPTSTTFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIP7</accession>
    <name>A0A0N1IIP7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01606</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ459752">
        <property type="protein sequence ID" value="KPJ20191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IIP7">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IIP7"/>
    <dbReference type="InParanoid" id="A0A0N1IIP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18598">
        <property type="entry name" value="ABC_6TM_MRP7_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18605">
        <property type="entry name" value="ABC_6TM_MRP7_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000037">
        <property type="entry name" value="ATP-binding cassette subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1234"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="345"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="698"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="1140"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1415"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ20191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1649" mass="182945" checksum="064261F0C98C63BC" modified="2015-12-09" version="1">MELDTKLQWNWKDMCGPLGFQPWIDERKDFGKCFQELCLQIPVLFITAIISGFYVGYRREWVIREKTQERAIVLRSFAVLGLTFIPIIELYIFISSNKFNLFPVDYFTAGASCLSWLVHFGYILALKHRLGPSSRGPLGLVLLWVMIVVLNLISLRTSIITGSIVGFDIATLCCHIVYFVTLLPSSESRPTFYSPHLVGSQHASSEYTPLLPHMDEGILGTAMQSTSWFSKLTFLWVNPLLDKGFENKLTDAEELYDIPTEYKCSYVGAKMDKALIGNVDQFQQYAEIPHEPFIGSGYGSLSESLPQVSTPVTPTSRVLLRPQRRQNVSLLRALHTCYAVQFYSIGILKLISDMAGFAGPLLLNKLVTFVEDESIDQHLGYGYAGGLLIATVVSAVFNVHFNWLMSLIGIKMRGAMVSIILRKTLSVTSTELTKSFSVGEITNFMSTDTDRIVNSCPSFHALWSIPLQLIITLFLLYQQVGVSFLAGVAFSVILIPINKFIANKIGQLSTELMRHKDSRVSLISDILRGIRTIKIHVWEDYFINRVAEVRGKELYYLRGRKYLDAICVVLWATTPVLVAALTLGTHALRSQPLDAPTVFTTVALINMLIAPLNAFPWVLNGLTEAWVSIKRIQKFLDLPDMDSDRYYDRVNTNHDEDKNVIFKNATFTWAKPATHQKPQIKSKKNKGKSTKRLSKRNIQQDSTSSSDTQVQVPFALRDISLEIGRGELVGIAGNVGSGKTSLLHAVLGEMIKVNGDLQIPENLNSFGYVSQQSWLVRGTIRDNILFGKPYDEAKFRSVVDACALTEDLNILGWNAYVGEGGCTLSGGQRTRIALARAVYQDKEVYLLDDVLSGVDARVAAHIVQRCVLGVLRHRTRLLVAHSHRHLARAHRVILLHDGKLVAHVYLLDDVLSGVDARVAAHIVQRCVLGVLRHRTRLLVAHSHRHLARAHRVILLHDGKLVAHGPPELVLNEIEEFLPSETDSLGEEPITEREHNLVEESLDNISRQSLDNEETMSMGSVGWWVICLYLRSVGLFLSVAIVLSLILMQLSQNYTFLWLTFWIKNRATNSTSLNIDSILESPHETQTVMDHGFNIMDNVIHRILNGSLPVLHSTDVTVTKSPKIPDLQLTLRYDDNFYLEMYFVLAGLNLLFTVMRAFLFAYGGVKAAGRIHRILVNVIIRAKVKFFDVTPTGRIMNRFSSDTYTIDDSLPFILNILLAQVFALIGGVAVTVYGLPWLAVALLPLALAYHRLQRRYRAASRQLKRLQSVALSPVYVHFNDTLEGLTVVRALGACGRWGERGEELCEGWQRAALCGAAAAQWLALRLQAAAAVTVAAAALIAVLQRATHAADPGLVGLAISYALSLTSVLSSVLNSFTETEREMIAVERVGEYITQVESEKIDGDPPPYGWPSHGVISFEDVYLNYNGERSCAALCGVTFASRPGERLAVVGRTGAGKSSLLQALLRLATPAAGRVLLDGVDVATLHLHALRSRLGVIPQEPFIFSGSVLENVDPLRQHGEAEVLRALTACGAREAVDARGGLHAPAAHLARGHAQLLCLARALLQRSKVLLVDEATANLDQEAERVIVETIRYSFAGSTVVYVAHRAAGVLQCERALVLAAGRVLELREPNDALADTDSHLYKLLNPQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIY6</accession>
    <name>A0A0N1IIY6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459628">
        <property type="protein sequence ID" value="KPJ20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIY6"/>
    <dbReference type="InParanoid" id="A0A0N1IIY6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="71" mass="8176" checksum="52629D6752E0D339" modified="2015-12-09" version="1">MSMGSGRFTIASNPDDRLLRSARQQLDDYIPKRLSKSERTEDITVVGKPDTYDRKRRISSPEFTGKIETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJE7</accession>
    <name>A0A0N1IJE7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom serine protease 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJE7"/>
    <dbReference type="InParanoid" id="A0A0N1IJE7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="35"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="512" mass="57012" checksum="8BC73BCAF87AF93A" modified="2015-12-09" version="1">MKFVDFLLSFIVLNEIETITGLKITAEVLNKTRRILRGTEAGDSKPFMVYLRPARDLENSVVDRNWLCGGVIIHENYVLTSAACIENIGHFYVVSGTHRWIPPGIQDDCITNGAMKAVWKCVPANYEYDGDQFENIRWMINDIAVVKVEDRFNFHRRVVGCDYVPKKIQFNNKSIDLEAPGTIGTLAGWGSQSNFGDPIQALERQTINSPVLMETNTMLMSKSHCKRRWPEQYHYIIEKSMICAKDSISGGELAGLCNDKIKCKELIDSQEDYGIRRSEKHIGESEIHNAAHSDSTGHRRAKISTGGFCEDKIKCKELIDSQEDYGIRRSEKHIGESEIHNAAHSDSTGHRRAKISTGGFCENDHGGPLVVGHGNSATVVGVIAACLTTNITRKCHGPFLYTSVLKGHLSKNDHGGPLVVGHGNSATVVGVIAACLTTNITRKCHGPFLYTSVYNNRLMIMCAVDKEISPACRSYVFRATNTKMVETTFSWIGHPDGWQTCKRPSEFAKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INI6</accession>
    <name>A0A0N1INI6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INI6"/>
    <dbReference type="STRING" id="76193.A0A0N1INI6"/>
    <dbReference type="InParanoid" id="A0A0N1INI6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="13090" checksum="C0B5EBEAC848735F" modified="2015-12-09" version="1">MLTTNERYFTMATTSPKNTIMFDDIRRNFIMNPKSGLKIRPFRQAHLNRDRDRELVHLSTYLREIAQYCDDFDQLNHKKWEKYKPDRNRTQHAGSKRKAEDSTPSTPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP69</accession>
    <name>A0A0N1IP69_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460709">
        <property type="protein sequence ID" value="KPJ12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP69"/>
    <dbReference type="STRING" id="76193.A0A0N1IP69"/>
    <dbReference type="KEGG" id="pmac:106713327"/>
    <dbReference type="InParanoid" id="A0A0N1IP69"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1274" mass="141424" checksum="C1D6B5F40163EB3B" modified="2015-12-09" version="1">MNGDIKAEAPRPRPLSGGIWTLFSWLRRDDRSISSESLSSAGSDHTAVSFAFLEPLNYKAATEPIVLPPLSPPTDSYKKRVRDRNFRRQRERNLTLHRKYGLFKGENGDRYDAFSLPSERKYITDGGNNIERGRRATSESFQRRAPYVPGKRRAPLPPAITASLPRNFSRKRPAPQPPNRLIVDDSVTLRSGLMNPKPNCDRRSLPNNVSMDINIEKSKQEKIKTDKSFLKQIFENRKRNSAIEPNYVKLLPNISELDKQAAKIIENKKLKLLEAKGTVSVNDIGSDPSGNWICAQCLRNYNNAVSSCSYCLLTKKYSEKASENNISLSNAASNIYTQTDNDLTKIGSTSKRNEEEEKKKLKEMLKEMKDSLPKRPKQNVLSTESPTLRIGSPRNKRISDPPTKNGSTSKKLDVTVTKDDIIPPSTSGKQNSAHCQIKSDSTNQSSTLLISSNTESKKVSSIPLMNKNLHDIPNVINYKEDSRHITIQVKESLLKTQKDVEDTEKVKRFQPTHQNTLFDNAVTQASSEVKAQTSSPLKLNMSTDVKHKNLTTVLFVSEGSRTKPIENLGNPKPEVTLTKASNKKLPTNGKTEKTDIDISTVPATDTRVNYLDKNVKSTKSIEVKTTKTNEDNFKVSTMSSAPSLHTPLRISSLLNPVYRPITSPKSASEANLKNVIGTKSDVVTLSSAVISQPPTVLINQRSLMPIEEISEPSEKETEEKQLQSLSFTKSQYSTNTSVCKVLGVTPSSSKDKQDKGVSKAEHHIRRRQLVNQLEQSIATGDEQAAAEAAVKLAKLRLSCSVLSFSSQIIGNPAVPRVIDSNPESEEKNDKSMKSGSKNDPMQVKVDNESPKRKDLPEKKSQLTCLNKTGEHENTNRPSTSKDQGGISKEDKSVMSQIDLKHKIPTSKSSHVENKTMAIKIWVEDKETTRGPIQFRISRQATMGELRGQAEASLGLDSKLQRWIVGRTLCMNDSTPLTTLAGPDLSAPFYLCIVESETKKEVTGDDSRDSKDDQSNEMIPDNGAGDVYTELMKLEQQAIVPNMDAFECGVCIDECEAGRGVVLRECIHTFCRDCLADVVRHCEEAAVSCPAIGCFGMLQEREIRALLSTEEYERWLARGLATAECGTRNAFHCRTRDCTGWALCEPGVRKFPCPVCKCNNCVPCQAIHDGETCEHYQTKLRTAVTAAQTNETDEGTRALLDSLKRRGEALECPECSAIITKKWGCDWVKCSACKTEICWVTRGRRWGPGGRGDTSAGCRCGVDGKRCHPSCGYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ72</accession>
    <name>A0A0N1IQ72_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ72"/>
    <dbReference type="FunCoup" id="A0A0N1IQ72">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ72"/>
    <dbReference type="InParanoid" id="A0A0N1IQ72"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="410" mass="46487" checksum="FA77F958B0AE818A" modified="2015-12-09" version="1">MLPRNKKNREYDLELSQEAIDLKNEIDVKESGTDNRNIFDDGRSQKLTPAEINDLRSDASRASDIVESLITNSKTFHNKTEFSQEKYLRKKVKKYFEYIQILKPNLRMITEILYKLDPSKIQGIRIDTLSQIITLCNISCEGTHLLYDSGSNGLLAAALLSAIGEQSSGKLIHMHPGNMSQKLALMGMNFSIEQLDRCVSVNVYSALRQFYQGCDTNSNDVSNKESIEGNELKRKAVENVNGHINKVTKIEVDTDVKSNKTNVSDNDKEDYEPKKPKWHFLNITASKLLSEKADSLVIACKEDPQNIFNELSDFVKPGRPFVVYYNVAEPLQNLYMTLKSKGNVSALKLTCNWMRNYQVSNCVRAEHSWVTNQGSGCWTKRAPHILPERTHPEVTMDNGGGFLLSGYIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQM2</accession>
    <name>A0A0N1IQM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_00157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01036617">
        <property type="protein sequence ID" value="KPJ21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQM2"/>
    <dbReference type="InParanoid" id="A0A0N1IQM2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14674" checksum="984239F127F58E5F" modified="2015-12-09" version="1" fragment="single">HDKVDGKWQFTCQHGPDECYGNKVQACILKDRSLQDTDKMELVMCLMSNASPDKSLDTGRHIRALHPTLVPTAPLYTRRPFTLGAPLRPTPLYAWRPFTLGAPLRPAPFYARRPFTPGAPLRPAPWAVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQQ8</accession>
    <name>A0A0N1IQQ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01054939">
        <property type="protein sequence ID" value="KPJ21556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQQ8"/>
    <dbReference type="InParanoid" id="A0A0N1IQQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="10946" checksum="D9246960FE4E61BC" modified="2015-12-09" version="1">MNRDTGPNKMETFIFEGQDSLLVGSTLCLEFNSILSFAENVTEIFDYHSMPALSELDDFDICLKKPDAVYCIVDLELLEDDTPLYQFIKVIKQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PF32</accession>
    <name>A0A0N1PF32_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_04143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PF32"/>
    <dbReference type="FunCoup" id="A0A0N1PF32">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PF32"/>
    <dbReference type="KEGG" id="pmac:106719037"/>
    <dbReference type="InParanoid" id="A0A0N1PF32"/>
    <dbReference type="OMA" id="KLCLHFE"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ07349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="50396" checksum="44940F8948C368BB" modified="2015-12-09" version="1">MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSESRFEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTKMPWFKGWNVERKEGKAEGKCLIEALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTIVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKVDRRTGKSTEDNPKSIKSGDAAIVNLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKEGAGGKVTKAAEKATKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PF97</accession>
    <name>A0A0N1PF97_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460973">
        <property type="protein sequence ID" value="KPJ10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PF97"/>
    <dbReference type="FunCoup" id="A0A0N1PF97">
        <property type="interactions" value="1802"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PF97"/>
    <dbReference type="InParanoid" id="A0A0N1PF97"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="10">
        <location>
            <begin position="367"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="691" mass="80112" checksum="3E90B1ABC7C1A1FC" modified="2015-12-09" version="1">MEKNNTDFTLPPARGLCFDRNDFIKTNFSVDTFLTDHQNVASLEKMRDDLGVYLKVLRLAMIELINKDYANFVNLCATLIGFDKAIVKIQVPLEQLNEEVVSVKQCLEDAMKELSIWLNQRHSLLKKKQLLKHYSQTVNNLRTLETVFRDISDKNKLEQIIVAERTALLYNQLKFTFSKCENLLSSEQKELYNDIGGKLIQFLNTLLFHFWNENDENNLLKTLLILTTLDRIKETELLIRKQAIAPLLQDIINEPALQRSKDGLQGIYTKILALLETKLKLFLKVMQHSTLTFLAKKYIFLVNCFWCEVESRIEVNLASIFAPGNPQLFYKRYSESIQFVRKLEEYCTAEGTVQLLHDTIEYKSFQKRWNLPVYFQIRFQEIAGGFESSLKKSPTVENKDGFIHKETLKCWISLHNCWSDGIYIEALAHKFWKLSLQLLARYASWSTSVCSQDSMQKLETTGINNTLIHNSLNIYVDTQTILQKLPSFLAHVESKIPIQNSKSLLKESLNSSIEILQQTESKIRDCIVNELYDNFNIQLKQVSDIPRLYRKTNRSIPTKPCAYIDVVTNSLREFNEVAVNKVDNLFLIGLYEALFNVMTVSYYKYVEDVLTSVQRTEESLRRLKQIRDMASQQNIESTGTTDGDKIRLQLNVDVLSYTRLAQSLSVEVHKVHKFNELSSMITEAVKNIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGB0</accession>
    <name>A0A0N1PGB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carboxypeptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460778">
        <property type="protein sequence ID" value="KPJ12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGB0"/>
    <dbReference type="FunCoup" id="A0A0N1PGB0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGB0"/>
    <dbReference type="KEGG" id="pmac:106713678"/>
    <dbReference type="InParanoid" id="A0A0N1PGB0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879730" evidence="12">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="121"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="430" mass="47650" checksum="B88933B3686180EE" modified="2015-12-09" version="1">MLKVAFILSLTFCLAFAKHEQYVGHVLYEVSVSDGQQAQKVHALENVIGIDMWSYATPSRPGLVLVAGSMRDYFQKQVTDAGAAFKIEVENVVDMLEKEDELLSAAVALSNGTDGRLSFDVIHRYSAVDAYLTSLAQQYSTVSVVSGGKSSEGRDIKYLRISTTNFQNNRKPVIVLQSLLHAREWVTLPAALYAIRKLVVDITDRDLVDDIDWIILPIANPDGYEFSHTNTRFWRKNRSTGHMIGNICLGVDLNRNYDYKWGTLSSNSPCSDTYHGKGPFSEPETVVLRNIIQQFRNRIELFIDIHSFGSMILYAYGTGDLPANALTLNVAGVRMAQAIDAVKWASKPNYQVGNSALVLSYRDSGSANDYVQAVGVPLAYTYELPARANSGGLNGFLVDPAFIEQAGRETWEGIKAGARFVLQHSRSNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGW1</accession>
    <name>A0A0N1PGW1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_03457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGW1"/>
    <dbReference type="STRING" id="76193.A0A0N1PGW1"/>
    <dbReference type="KEGG" id="pmac:106716448"/>
    <dbReference type="InParanoid" id="A0A0N1PGW1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879759" description="Lipase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="47145" checksum="427188A7E374742C" modified="2015-12-09" version="1">MNTKRGSIGGCVLCILIFSAYSLGQNLTAAQNAKDDHLQDASSNFTSISASYGYISEEHTVTTEDGYILTMFRIPKGKRCLGSVRQPPVLLMHGFLLNSDSWTDAGPTASLAYLLPDACYDLWLGNVRGTDYGRRHERLDPDTDSEFWNFTSNEMGKYDIPSFIDYILNRTSSTELIYVGYSQGARILIIMCSETEYCNKIKLFISLAPAVRLRYTRSLPFRLLVNFYELILPLLTNPNELEVLPKGGLIQSLAAYFCRDYIAAATVCKLALNLIDSYDPLSVLTQTARVLFGHTPAGSSARNVAFYSQSFAPTFNKYDYGADKNLEIYGSVEPPQYALNRTTIPVVLIYGKNDYLVDTKDVMWLSTQLPNVLETYQVIRPTWNHLDYTYSQFTPLQIFPKINQYFLKYTDKVLSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJS5</accession>
    <name>A0A0N1PJS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01034000">
        <property type="protein sequence ID" value="KPJ21257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJS5"/>
    <dbReference type="InParanoid" id="A0A0N1PJS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="12933" checksum="9273DA2AF0D49ED9" modified="2015-12-09" version="1">MYILNRPRRARRRRSAVGGRERRRAARERDSLTRSLERIHRKRRADRDRPSDADLKRTYTGLDRAYAEQFIAVCDESRHAAERLDSLASTDTSNTAHDRDTHRDPHRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMF4</accession>
    <name>A0A194QMF4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMF4"/>
    <dbReference type="InParanoid" id="A0A194QMF4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="168" mass="18725" checksum="5E63B191CB4B0EE7" modified="2016-10-05" version="1">MTTEEIQVLNELPIDKLLRIKNSLQEVSTTDNITVTEPTFIETFGAQAMSLRSPIKRTDYEDGYKKEVSKISNIFSMSVTTLAFLAFGGYLLCLIVQAVKSKHAYSTANVPQSTLVLNAGIKRPQTFASYGRKKREAEVPNEIDLPPEQLFTALIQLCEGYAKWNGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMQ2</accession>
    <name>A0A194QMQ2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulin-like growth factor-binding protein complex acid labile subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMQ2"/>
    <dbReference type="FunCoup" id="A0A194QMQ2">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMQ2"/>
    <dbReference type="InParanoid" id="A0A194QMQ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF170">
        <property type="entry name" value="RE50361P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264489" evidence="3">
        <location>
            <begin position="17"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="581" mass="65764" checksum="4BF0AFC755A4945A" modified="2016-10-05" version="1">MLLCVALCARPVVSQGTQQCPASNTITPCSCTVKKNGLDILCEFTEQQHIQKAMNTLRSKPMIIFYLKLRHNNLAKLPSYIFLGLDIRHLTVHNSSLAVIEDSSLSSIGNKLTQLDVSQNSLATIPTSSFTHLNHLLILNMNHNKVTAVHNRAFIGLDTLEILTLYENRISVVDAEAFKGLEKKLKRLNIGGNELTAVPQKALALLENLKKLEMQENRITSISEGDFAVKIRTIFYVTNVTQSRSYLKEFEYVTAVHNRAFIGLDTLEILTLYENRISVVDAEAFKGLEKKLKRLNIGGNELTAVPQKALALLENLKKLEMQENRITSISEGDFAGLRNLDSLGLAHNQLREVPAQVFSHLTFLNSLELEGNQIQRIDEKAFAGLEENLQYLRLGDNRLHDIPSEALRPLHRLRHLDLRSNNITYISEDAFTGYGDSITFLNLQKNMIHQLPTMGFDNLNSLETLNLQNNKLQHIPEEIMEPILDTLRVVDIMDNPLICDCELAWYEAWLSGLRDRDDEMMQKKRTVCTMVNEHREYSVAKMPLEKMSCKRKPPYGRPSGATKTKPIIATNALLIIAARWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMT8</accession>
    <name>A0A194QMT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfotransferase 1C4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMT8"/>
    <dbReference type="FunCoup" id="A0A194QMT8">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QMT8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="336" mass="39564" checksum="8E6A392ED2DBE1E9" modified="2016-10-05" version="1">MQDLTNRFPFDIRDVEGTDNKELSKYFLGAGKFNIQVGPKKYLLMSDYKHDAENIYNMPLRHDDIFLLTFPRSGTTWTQELVWLLVSDLDHSTAAKVPLSFPMLMHNNIVEHLNKEHANNPDNLKTLQLMRTPGSEQVAKMPSPRFIRTHLPLSLLPPTLLDSTKVVYVARDPRDVAVSFYHLSREFKSYNFNGGFKTYWSLFVRDLVYWSPFFEHLKEAWRMRHHPNMLFLFYEELLQDLPATVQRVANFLGKQYRADQISELCTYLKFENFKKNPSVRFGNLKEYGMMAPKGEFIRKGKSGGWRNYFDEDMTREAQCWIDNNLQDTDMKFPTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNJ7</accession>
    <name>A0A194QNJ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNJ7"/>
    <dbReference type="InParanoid" id="A0A194QNJ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="6930" checksum="9E04303B716BF79D" modified="2016-10-05" version="1">MVAAGGRSGPPGGSRPGRPWWPRYTTREIPSGSAAVVTLHRQGTDVAGVAALYHYVSGRGGHFDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP28</accession>
    <name>A0A194QP28_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8 carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP28"/>
    <dbReference type="FunCoup" id="A0A194QP28">
        <property type="interactions" value="2005"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QP28"/>
    <dbReference type="KEGG" id="pmac:106719631"/>
    <dbReference type="InParanoid" id="A0A194QP28"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ06730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="183" mass="20854" checksum="F1DD4DFAA5357051" modified="2016-10-05" version="1">MIKLFSLKQQKKDEEGSARAGGSQKKASAAQLRITKDLNELNLPKTCSTEFPDPDDLLNFKLIICPDEGFYRGGRFVFSFKVGPNYPHEPPKVKCETAVYHPNIDLEGNVCLNILREDWKPVLTVNSIVYGLQYLFLEPNPEDPLNKEAADELQSNRRLFEQHVQRAMRGGYVGASYFERCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPG8</accession>
    <name>A0A194QPG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPG8"/>
    <dbReference type="FunCoup" id="A0A194QPG8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPG8"/>
    <dbReference type="KEGG" id="pmac:106718915"/>
    <dbReference type="InParanoid" id="A0A194QPG8"/>
    <dbReference type="OMA" id="PMMQQID"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="17372" checksum="744D662D5D29FF66" modified="2016-10-05" version="1">MSEEDDTWTADRKNKDMRMFQSCSSFELSDPHDPVLSRLATQMFKRTNDYLQGEMTAGQDHYVLLEEINRLVITKYADLRSLAVNLTKSINESNEKYETEIKPLLQHIEDIDNEMSVLEATAFRLDSYTKQLLARFVELLDIDNNSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPI2</accession>
    <name>A0A194QPI2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08456</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPI2"/>
    <dbReference type="FunCoup" id="A0A194QPI2">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPI2"/>
    <dbReference type="KEGG" id="pmac:106718913"/>
    <dbReference type="InParanoid" id="A0A194QPI2"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19218">
        <property type="entry name" value="SET_EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044439">
        <property type="entry name" value="EZH2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="14">
        <location>
            <begin position="503"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="632"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ07443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="766" mass="86936" checksum="F77B08D29C2C61A3" modified="2016-10-05" version="1">MSKSKVSAEWKKRVKSEYMRLRQMKRFKRADEVKVAWARNLRIMSEAIEARESETAERGRRPFWPPPSPSPSHESLMKRAEVTYTDSLGVVTTQQVPIRIINSVNPIPTMYTWAPTQKNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDKEGGFIDDQLFVDLVHALMTYQTKDEVAEERKERELRNSKEDKDKDTSKEGKEKEKDKEEVKDGDKKAVVDKQFPIFTIFQAISSQFPDKGTAQELREKYVELTSLRDPDALPPECTPNIDGPLAESVPREQTMHSFHTLFCRRCFKYDCFLHRLQACHPGPNLSKRKGPDLKPFAEPCGPNCYMLLEGMREKLAREQAAGEEESGKAHAIDSPNDASSEDSNDSNRYQKGSNSNSSNSNWSSNGVGKGADPAAAADPAYNALGLTVGDIESEWTGSDQSLFRALHKVFPSNYCAIAQLMLSKTCQQVYSYWIRTGQEECRVEAELTPPRKKKKKHRLWSVHCRKIQLKKDSASHHVYNYTPCDHPNQPCDNMCPCLQSQNFCEKFCQCSSDCQNRFPGCRCKAQCNTKQCPCYLGVRECDPDLCVACGADAPSPGPAPPHAPPHAPPHAPALRQHAHVYCRNVSVQRGLHKHLLLAPSDVAGWGIFLKEAAHKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVNGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRI4</accession>
    <name>A0A194QRI4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_11146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRI4"/>
    <dbReference type="InParanoid" id="A0A194QRI4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ07590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="688" mass="79632" checksum="192593BCD71197C6" modified="2016-10-05" version="1">MRCSVPNCTNDTKRTTKRHGITFHMFPKEPSLRTKWLEALGKMDWEPKCRSTVCSEHFRTEDLYKTKFGLRKIKNGAVPVLVQESSEDLNSSAVLKVCRICLAMDRKLYHIIDYKLDLPYQQITGLMISEEDDLPQKLCWECTHRLISCQRFRNKAIMSQGLMTDVLETEKHLTVRCIKSLIQKEDGLSSTLIKKSCLDPDYCDIHVKEEVVIEPHYMNDVIDDVGFNQVVTKDEINLEDNSIFLNESNFENKDEVFNINNINKQDTANLDENNKVPVNNNINSGDIKKGHSGIDGVKLDVIKSDSKNIKEAVPTSEDKVYKVNLSIMEPEVKIDEDAFLEEYNSSSESDDEFFKMENTKKIETKLIKKGKQESGDYECPICKTRMMTKRAQKIHIGSLHTEKMACNRCDFVTKHRGVAVRHLEWHDGTTFKCPHCPSEFEKRSSYLGHLRLKHVSDFACELCGYTFLSKKGVYGHKKRKHKLKRGSPITLDGPYCEVCEVRFASEMAYNTHLKVSSKHSTDDDPNRIRNDYIDVDHVIESVGRGKGRTIAKDSNRPEPKLVDCEQAKALLLDHMWVHTGEKRFKCSLCDKSFSMHCNLVNHQMVHSEERPVYDCEICGKGFLFAANRKRHMIIHSGLKPFKCDVCEKTFKSNAEKRLHYDHVHLKKPWPRRVHRTHRNRAEHYKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSV0</accession>
    <name>A0A194QSV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSV0"/>
    <dbReference type="InParanoid" id="A0A194QSV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="463" mass="50466" checksum="4657B8204ECE76FB" modified="2016-10-05" version="1">MSKKQVTSEFKSNETWRILKNVVIISIAFMVQFTAYSGAANLQSSINAEAGLGTASLAAVYAGLIFSNIFLPVIVIKWLGTKWAMALSFVTYMPYIAAQLLPRFWTLIPAGLFVGFGGGPLWCSKCTYLSVVSEAHSKISNISAEALLTRFLGLFFMIFQLNQVWGNLISSLVLSSGDNEAAVTALNESLIPELCGANFLPSADAGDALQPQPPEKIQMIVEILAIACASYDTGRSGSGTGHSGMALLVVTLKLLIEPNQLMLVTINVFIGLQQAFFGADFTAAFVSCAIGTGTVGFVMMTYGVADAIGCVVTGYIAKVTGRLPLLCTAAIVQAGLFVSILTWRPHPSEEYVLYIIAILWGLCDSVWIVQINAYYGILFPGREEAAFSNFRLWESVGYIIAYVISPYLRTSAKTYLLIVMMIIGIALYFVVEYRDRKAKKKLDEKKKDLYTIGCDNIAFQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTY0</accession>
    <name>A0A194QTY0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTY0"/>
    <dbReference type="InParanoid" id="A0A194QTY0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="106" mass="11426" checksum="71C34158DE524B14" modified="2016-10-05" version="1">MVGGFTHPSGRAASAASADGAAEECESVPVAPSPMRRRNRGGLAEDVWLQTKSGIEKSSRGPGALLLTRILLLNRQDIKENGTDITVKRSDVYVLRHLGQSEARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU24</accession>
    <name>A0A194QU24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase RFWD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU24"/>
    <dbReference type="STRING" id="76193.A0A194QU24"/>
    <dbReference type="InParanoid" id="A0A194QU24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="469"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="555"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="689" mass="74519" checksum="6CA5C89EF3AFF3BB" modified="2016-10-05" version="1">MAFATWIKQHSRVGSAMAAIMSGTAATVGGAGAGPGGGGAALGGLGGSLEDKDCELLCPVCFELISEAYVTRCGHSFCYACIAKSVELQRRCPKCGAALASREHIFPNFLLNELVARRKLRARPAPPAGEAAEGVRLRALVAAEARHLGLAEVDGMLDVLTRRKRLLQAESAAAQHRLLYEFLSQLLRLRHHQLDQLAREATLVRSDLEQVGRVLRELRAGAPEPPRPLSPHALDHASEQQDCAEERRGEEEESFAGGPGGGAGGDAVAARWRRLTTHFDDFVQCYFAHRADELYFPGSSSATPTPGLGSAPGASRAPEGGEAGAGVGGGAGSGLGGAGAGAVEPCGGLEAFRADLAAFTRYRALRPLATLSYCSDAINYSTIVSTIEFDKDNEFFAIAGVTKRIKVFEFESVVRDAVDVHYPCAEMQCAHKVSCVSWNAYHKHVLASADYEGTVSVWDAAAGTRTRALQEHDKRCWSVHFNRADVRLLASGSDDARVKLWALNTERSVATLEAKFNVCCVRFNPASACHLAFGSADHCVHYYDLRAPRAPLAVFRDHRKAVSYVKFLDARTLLSASTDSQLKLWRVESPRCVRSFTGHANEKNFVGLATDGRYLACGSENNALYVYYSGLSRPLLVYKFEALRGFLERERRDEEPSEFVSAVCWRSAPDRPALLAANSQGTIKVLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUB1</accession>
    <name>A0A194QUB1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_15198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUB1"/>
    <dbReference type="FunCoup" id="A0A194QUB1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUB1"/>
    <dbReference type="InParanoid" id="A0A194QUB1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000101">
        <property type="entry name" value="uncharacterized protein LOC108094628 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000112">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000089">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="472"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ09057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="818" mass="90532" checksum="C959B0641433249F" modified="2016-10-05" version="1">MYAGYAAATCRFPGAPAHSRVDFSDESLADGSVASYTCERGFELLGPARRICGQDGTWTPDGIPFCVLNVAAGKAPMQISTEESGAPQRALDGSTSAVFSAETCTLTKTERVPWWYVNLLEPYMVQLVRLDFGKPCCGVNKPAVIVVRVGNNRPDLGTNPICNRFTGFIEEGQPLFLPCNPPMPGAFVSVHLEGAAPSQLSICEAFVYTDQALPIERCPQFRDQPPGSTATYNGKCYIFYDQQPSNFRDSLAFCRSRGGTLVDESNPALQGFISWELWRRHRSDSSSQYWMGAVRDPQDPNYWKWVNGKDVTVSFWNAPGDGEGCARFDGSKGWLWADTDCQARLNYICQHQPKACGRPEQPPNSTMTADSFDVGATVEYSCDKGHLLVGPTVRTCLDTGFYDEFPPVCKRIECGLPAEIRHGTYVLVNGTTSYLSHVQYYCEAGYEMAGRSRLVCDIDERWNGPPPRCEVVQCEKPVPIQNGRVSVAGNASVFSAVAEYECARGHRLLGPRQRTCLATGLWDQPAPQCQPEERPTTTTTTTTTTTTTTTTAPPTTTTPIPLTPSSTTPRVVLPTRPRPSQRPISSPTPFAPAETSRRPRPKITTTDRPTTRSYEKPPPRKVTVSDSQDAATSHVPHIIVASHPRENQILGSGNNIRAEETPRVNVPQPVDGERREGARLNIGSIIALGSFGALVFLIALITTIVILFRSRKHNHGKRYRHHVSPDCNTVASLDSSSSESRSGLNRYYRQAWEELHEAAGAKHGHRRHEREAPKDGSELVVADVCPAPHSRDKRRHHHHHRRDWAPSHRPHHNHKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV97</accession>
    <name>A0A194QV97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding cassette sub-family A member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV97"/>
    <dbReference type="InParanoid" id="A0A194QV97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="569" mass="65184" checksum="163191D216FAB399" modified="2016-10-05" version="1">MTAWIACTWTTLFTLMQTFISELLVHHKFDIENKALTFVLQVILPPLGLVHAFNEFALLQTGREFDNVVSLVYPILSWLLMIAFYFFLLMTLQRTISFEKAIGGQVPWKTVLFKKSTDINKLHRIESLTGTERDNLQAVDELVAKAISFRNVSKSMMGSVVLSNVTFDVYRGEFSMIIADRIQHKMIVTLTDLFTGLTFADKGTINVLGHELRPGSNFMNVPYMTGFCHRNQCLIHDLTVEEHLILFLEIIILDNFTMMPVYDALIKDKIMRYKKYITIVKFSFTSIKMEFADRVFLFDDKTLIFGGTPAYMFFKYGREYRLRLTFEAGILENEAMPEILRRAQGAGARVRANLGSLLILMVPVFPTASVAAFIKELTIHTKEYGITSMHISVPDSQEVCHSYILSDTNSTDAEIDFIEYTAFAEKESLTEYLVTRAIDSPQHYVTLYAYGIEIYDKNDTLKVRVLHSPPHQDSWTAPRSLARTFMALLRHYSGKKDATIQVTDDPLGLDLARCHAMNFSPVRYWFTMFLCDLVLYSILVSFMTALTIAVIYLVTPPTYFHIDDLCKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVB3</accession>
    <name>A0A194QVB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVB3"/>
    <dbReference type="InParanoid" id="A0A194QVB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="9158" checksum="5FF175D04E02C632" modified="2016-10-05" version="1">MFFHESYDSDSDYEEDMQLWALATLLIKQRKRRRYWIHPLNTKRETKGEFHCLVKELESDAKKFNQYFRMFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVZ4</accession>
    <name>A0A194QVZ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVZ4"/>
    <dbReference type="STRING" id="76193.A0A194QVZ4"/>
    <dbReference type="KEGG" id="pmac:106718731"/>
    <dbReference type="InParanoid" id="A0A194QVZ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="315"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ07736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="37622" checksum="C73DCAAB187C24BF" modified="2016-10-05" version="1">MPNIINEVKLDFKDVLLRPKRSTLRSRNDVDLYREITFRNSGQTYRGVPVMASNMDTVGTFEMAKELSKHGLFTCIHKYYTIDEWKKFAADHPECLEQMAASSGTAEADFDRLSEILNNIKDLKFVCLDVANGYSQHFVEYVRRVRAAYPTHTIIAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRIKTGVGYPQLSAVIECADAAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMAGGMFAGHDQCGGDVVTKPDGKQVKLFYGMSSSTAMLKHSGGVADYRSSEGKTVEVEYRGDVAVTVKDILGGLRSACTYVGAARLRELPRRATFIRCCRQVNDTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW36</accession>
    <name>A0A194QW36_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_13382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW36"/>
    <dbReference type="FunCoup" id="A0A194QW36">
        <property type="interactions" value="1710"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW36"/>
    <dbReference type="KEGG" id="pmac:106716587"/>
    <dbReference type="InParanoid" id="A0A194QW36"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="53"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="411" mass="45619" checksum="5DE3B0D1DB55BFA1" modified="2016-10-05" version="1">MWLTKCSKLYCNKLSPFNGLTKRTLSSSGKATVLGIETSCDDTGCAVVNSEATILGEFLHSQNEIHVKYGGVNPINAWELHRDNIESVVNTALDNARIGLNQIDAIAVTTKPGLLLSLMIGVKYTNFLAKKYQKPIIPVHHMEAHALVTRIYYDIPFPYLALLISGGHCLLTVVNDVDNFLLIGQTLDNAPGEVMDKAARRMKLKNMPEYSLISGGRAIELAAKNATNPTLFKFPIPLQRNRDCDFSFSGLKDSLVRKVIKKESEHVLMGDEIIPEVYDLCSSFQTSITKHLAHRLERAIKFCEVKNLLCNSAKNIVVSGGVACNDYIYSNLKSVVNHLGYNLYRPPHRVCTDNGIMIAWNGIEKTRKGIETCHFISQSDVDPTAPLGVNIRNQVKEANITVKSPRFSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWX4</accession>
    <name>A0A194QWX4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein MEF2BNB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWX4"/>
    <dbReference type="FunCoup" id="A0A194QWX4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWX4"/>
    <dbReference type="KEGG" id="pmac:106716948"/>
    <dbReference type="InParanoid" id="A0A194QWX4"/>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="19840" checksum="F78A910C825230E4" modified="2016-10-05" version="1">MAFVYQSDSELETKARKAAERISENMHIVANEPSLALYRLQEHVRKALPPMVERRVEVTKLQHELQGRCYDVEYALSAVKSMDGAANSFKNIQEMLKQSIYLKQQLKYEESRRNKKDTSSVYKRLSAHIVLDLPDLSDFSMVRETTNRIENMMAHARGSNNELQRSHTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY07</accession>
    <name>A0A194QY07_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin complexes subunit BAP18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY07"/>
    <dbReference type="InParanoid" id="A0A194QY07"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF2">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15148" checksum="9DCFC0DBC30CD9B3" modified="2016-10-05" version="1">MADTRTTLTSAINHTLSHIFWEAGAAFGKLSELTRDFHNMNDSQSSCKWNEEEVEMLRACVHRFALDLHQLSVHIKNKTIEQIKRTLRKKAFEDAGIPLREASGPPEPPSASCTESSDVSSDPESWTGTTEEEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY70</accession>
    <name>A0A194QY70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY70"/>
    <dbReference type="STRING" id="76193.A0A194QY70"/>
    <dbReference type="InParanoid" id="A0A194QY70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12197" checksum="5ACC3DC07D176568" modified="2016-10-05" version="1">MMSHEKSNASEDAEITIDQYSEDNDNIMIKSTLQDDILKMLLKARFEGKTKMGPDVLPLVKQLANCLIMECCHRAGRLAIKEGCTEINVEHIEKCLNQIVSMVFIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYA2</accession>
    <name>A0A194QYA2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methuselah N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYA2"/>
    <dbReference type="STRING" id="76193.A0A194QYA2"/>
    <dbReference type="InParanoid" id="A0A194QYA2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19593" checksum="2C67FE7C829D2D71" modified="2016-10-05" version="1">MTYSRKKKELKDISFLNFGQGWLQNPCKRTESLNITNGVVFDNGTVLFNGVQYTRETWYDLEEDGVVTRYGCPCIGRTCLWKCCGEGQAFFNKSCLDTDYSAANPFNPPVHKGKDQVDFASNKFFYMYTKLCTERYLVDPNTGLEDIFIQEHLAISDQFESTDQPRILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYQ1</accession>
    <name>A0A194QYQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0480 protein C15orf24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYQ1"/>
    <dbReference type="FunCoup" id="A0A194QYQ1">
        <property type="interactions" value="1629"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QYQ1"/>
    <dbReference type="KEGG" id="pmac:106715788"/>
    <dbReference type="InParanoid" id="A0A194QYQ1"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="226" mass="26150" checksum="B1BC2D3B169B5950" modified="2016-10-05" version="1">MKQISYSTILIIVYSFAYVSNAINSVEEDIGSGRYVIEGRVIPPEELEQRNWQTQTRIHVNGGEYIGFIKEDGSFAIHNVPTGSYVVEVVNPDYMYDPVRVEINSKGKYRARRVNYIQTSQVIQVPYPLRMKALSRFRYFQIREQWRLTDFLFNPMVIMMVLPLLLIMVLPKMMNDPETKEDLKQITNLAKMSEMPEMSEVFTNLFSGGATTKASTSKAKQIKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYZ7</accession>
    <name>A0A194QYZ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYZ7"/>
    <dbReference type="STRING" id="76193.A0A194QYZ7"/>
    <dbReference type="InParanoid" id="A0A194QYZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="218" mass="24526" checksum="DBB675401E4069A0" modified="2016-10-05" version="1">MDGLILNTEDLYTIGFQKIASIYGKEFTFDLKCRIMGQQTREFAASIINGLDLPLTVDEFVKETRFIYEELFPQSKIMPGVERLIRHLRDNGVPIGLATSSSKETYDLKVKNHSGLFDMLKFKTWGSSDPLVKRGKPYPDIFLVAADKFPDKPAPEKVLVFEDSINGVKAAHSAGMQVVMIPDPRLDRSLAPEATLILNSMVDFRPELFGLPPYTQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R017</accession>
    <name>A0A194R017_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_15332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R017"/>
    <dbReference type="STRING" id="76193.A0A194R017"/>
    <dbReference type="InParanoid" id="A0A194R017"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="424"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="899"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ09191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1190" mass="133868" checksum="6AFC64877563C247" modified="2016-10-05" version="1">MPGSRFRVPGFSCLRDDRNDGYAGSAILVRHSLPFSQIPLPPHSQQINAVAVRALDISFVSVYIPHPTPSLLPELQSILSSVPSPIIALGDLNTHHTMWGCYGCDGFAPLLIDILDDVGLCILNDGSPTRRVFPNQNPKTAVDLSLCSPNLASQITWKTLPSSYGSDHFPIILSLNNRSFLPSSHDPLLKYQLKKAKWTEYARSVDFLIDSLPDPVSDGNILACYDLFLKSLISSADSHIPKKHPPKNHLLSSPWWDDECNDLFAQRTSAEKTYSNCMSQENFIKYQRLDSKVKKLVTRKKRSSWTRFCESLSPRSPSSIVWTNIRKFRRSLNHTDPSSNNPLDWLNDFADKLAPPYVPNIDSFPNFTPTPSSDDMDAPFSFSELQIALNGLKDSTPGEDGVPYSFLTNLNDKAKIHFLNIINKFFETGTVPHSWKSQIVIPVIKPGKNPLDSNSYRPIALSTTLAKITEHLLKNRLEWIIESKNILPSSQFGFRKGLSTTDSLGILTTDIRIAFTKGEYLAGVFLDIASAYDNVQLPVLRQKLQSLSIPPKLTHFICSLLFCRSIVVKHQSSSLPPRLVWKGLPQGSVLSPLLYSIYTHDLELSVSSFCNILQYADDIALYHSSGSVEEISCRINSALYYLGQWLSDHGLSLSVGKCQAVVFTRKRSLPSFQFSIEDQLIHLSDKIKFLGIYLDNRLSGIAHSEHIIKKCEKGINVIRAVAGVWWGAHPYSLKLLYNALVRSHMDYCMFILEPFNKSAVQKLNNIQFRCLRIILGAMKSSPTNALQVECVDPPLTIRRQYLCDRFVSKMLQLSSHPLWPRLTQLSSAPQSRNSSSYLVDSFLKYTNLPHPVSTFPLNPLFSTPYNALVYNPLIITDIGLVKGAPDTNNKFQNYIHQNWSNHILIYTDASKLSPDGCVGAACWVPRYKIILKFKCPPESSVFTGEATALLEAILFAHSHNLKQTVILTDSLSCLMSIKENPFRSKSRFPIILKIREALLSCNQKGLTIILVWIPSHSGIPGNETVDSCAKLAVISGSLDHFQNSAQDLCGLAKTYLNRSWNTLWNESKSIKGKYYASIQPDIPTRPWFFKYRNADRWVTSTISRLRLGHSCTPVFLAKLRIRNSSICECGLDEGTVSHILFNCPKLLHPLYDVLPPNIPRPVNVEYLLTFVFSSYCRFLCKYIECNKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0X3</accession>
    <name>A0A194R0X3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0X3"/>
    <dbReference type="STRING" id="76193.A0A194R0X3"/>
    <dbReference type="InParanoid" id="A0A194R0X3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="35324" checksum="5D2984F7C1FA8BA5" modified="2016-10-05" version="1">MHLRYGGIIPDIARDLHSRFVEPVVSETLKEARVSMDDIAAIAVTLKPGLPLSLAVGMKYAKHLARKYDKPIIPIHHMEAHALVARMQHNIEFPYLTLLISGGHCLLAVVEDVINFKLLGESIDMAPGEMFDKVARRMKLRNIPEFAQMCGGQAVEVAGSRATNPHLFKLPLPLADYKDCNFSFNGLKTSVLLHLHRKEKEHQITADKLIPEVNDLCAAMLMATYRHLVHRTQRAIEFCQQNNLIPDSKKQLIVSDNGVMIAWNGLEKWRRDLDIVTDLNSIDIEGTSQLGESFVSKVAEARIPIKLVKIKMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1C9</accession>
    <name>A0A194R1C9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1C9"/>
    <dbReference type="InParanoid" id="A0A194R1C9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="31443" checksum="CA991A9A9AE31896" modified="2016-10-05" version="1">MIIFVKSAPKLGHILFDPLDYEANLTREVTSETENSTSSQYLRSNLTIQYLTTKASNNSNGYGFDETICKEKNDRILCGYNKNKDNLGIEEMLEETENGCRIRGDRLECGYLVGPFTNPRRPPANYEENEDTNNTQSELYHNTTQATVSIDIHHDHCVRNLAKMKTILFFTLLMCIYLSFTLAIPHPGNAEDLQASESNWGGGWGRGYGGGYGGGTEVAGEADGIRVEVGVTEVVGATVEDAVTVELHLRTPKPRPLHTPAVQWRRECGTRRPQKATGIPTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1Q2</accession>
    <name>A0A194R1Q2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Glutamate [NMDA] receptor subunit 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_15088</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1Q2"/>
    <dbReference type="InParanoid" id="A0A194R1Q2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000191">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000324">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264854" evidence="18">
        <location>
            <begin position="18"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="982"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="19">
        <location>
            <begin position="742"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="20">
        <location>
            <begin position="750"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1304"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1502" mass="168680" checksum="DA1178493251151A" modified="2016-10-05" version="1">MRAHLALLVVWCALAAARDLRVLQADARAVFFVGIAAPASAAAVVRAFNRSLAEVSRAYFAADYPLHLRNITLQPLYIELPEDERFSTRVLEATCAALAGRRVAALLVCGGGGAATAVVTAAARAGVPVLRTSPSHLHLSYTIANDILPLEIRLEITARETLHALRATLLHTHWHTFTLLAEEDIYSSLYLRKDLSSILTTQPLNPIWLSLPTKYSRHAIFRRLAEVSRLTRGVVVLISDIQYAKLVMDEAERLNMLDGHFFWLWLDASSEFDVFQNIVNSTQYTEDSIRDAASSSYKDEALFYDSFERSKRDDADNNSIVDANFSSSSITYNKITNNNVISEYILKLDNSHGRRSINKSKAHIKNKLLNVNLINSYNVSQNSSSESIRKINVDKKGVESSKIENDLLEKEDVSSFHVNNIHKDNIETTSRSKTENESFSKYVNSITFKDLGKARKLLKERYIDINVKDRELSDSVFFSSDISDFLLNPTVHTSTTNNVRDKLVKRTDKYLMNDEKTVDENNGDIKKLKENRSTVFNNLPVGLLALYPQPMKIDETFIRSAVRLTVSALYRVLRACDAWSAQAQFLSDAAASCWEEPSDAAADFSIEFVREMRVLSAAALAGGFGRQDTSLTATFSFLNLILNPEGGNVWRQVGHIRGRDVQLHTIVWPGGRLVAHGQSAGARTIFRIVTALAPPFVMEGELDEDGQCLRGLACHRPQTSDRDNLTLVFNVLERENDQDSNDFFFPTPKPTTFSRMATHCCYGFAMDLLENIAQELEFDFHLYIVEDGLYGSRKLVKPFQRAVDKNTENAFWSKHKNSRLHNTDDDRVTSSDNADSLGTKEDLEKWNGIIGDLVSGAAHMSFAALSVSAARAEVVDFSQPYFFSGISILAAPNQRPDIPLLAFLLPFSPELWIAIFTSLNVTAIAVAIYEWLSPFGLNPWGRQRSKNFSISSALWVMWGLLCGHLVAFKAPKSWPNKFLINVWGGFSVIFVASYTANIAALIAGLFFHNAVDDYQGRSNWLSLRIGTAKSSAAEYYVQRNNPHLAEIMRRYALQDIEEGIQRLRNGTLDLLIADTPVLDYYRATDHGCKLQKVGEHALAKDTYAIGMAKGFPLKDSISAVIAKYSSNGYMDILTEKWYGALPCFKLSADYGIQPKPLGVAAVAGVFILLGVGMIVGCLILILEHLFYKYTLPILRHQPKGTIWRSRNIMFFSQKLYRFINCVELVSPHHAARELVNTIRQGHFTSLFQKSVKRKEHEQRRRRKSKAQFFEMIQEIRRVQQCRDHSLDSIKENVAIETSEVSEEVTESKFLSPSPDVSSRSPRPGRSPRQLRSPKSRRKRCSVAGLNVRRFSTDSVLGSDSASIYERTSLNIGRRLSRDVSCLTNSPPDINTRLRTPSPMARRVEGSSTRSYQDVSERSNNYLSIDLPTHGASIEIMVSQEHDLPPAPPYPKVSHSGGRSQLSQLSEEELIRLWRSSEREIREALLAALHERRANLDPKQDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1R2</accession>
    <name>A0A194R1R2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1R2"/>
    <dbReference type="InParanoid" id="A0A194R1R2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="58DAE0D624F4DBE3" modified="2016-10-05" version="1">MSVEHFRAITASGATVGTLRSAYWMAARLAMSQGHRRTYAAFSKQHFPKVSPLHPATLPLIGRGLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R327</accession>
    <name>A0A194R327_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein 3a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_09861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R327"/>
    <dbReference type="STRING" id="76193.A0A194R327"/>
    <dbReference type="InParanoid" id="A0A194R327"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="193"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="289"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="380"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="475"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="571"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="664"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="753"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="845"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="978" mass="107163" checksum="7DFD0BA3E75EDD7C" modified="2016-10-05" version="1">MIHSDPSDNKSSNNASEKGPTNGAGGPQHFYGAGYPTHFHHVPAHHMQHSPPPPVYQKDERTQRQYSKLKQKLERKQTNRNNGGDDDNDTQAFLDLLSATRTPQVSDITPTSALVQWNSPLPEGVTLPNVELTYELLLGDRGRYKAIYSGPSLSCRVRDLRPGCEYSVCLQIRAGEQTGAASEAATFRAPPAPPARMTPARVANRARTSLLLRWSPAADNGARILHYVLEMDAGEGFAEVSRPRTRQHTVNNLRTQTCYRFRIAAVNECGPGEWSEEFVGWTLGAPPPAPAPPALRDAAADSLALAWERRPDEEFTLQMDEVARGHGFLPIFTGTECSYVCTALRRASDYRFRLRCENADGQGPWSQEVTYRTLPERPGAPGRPTPKGKIHSRAFRLRWEPPTDDGGAAVENYTLEIDGGEGYQSAYTGVEREAHCDRLQPGVQYRARVRCANVAGESDWSATETITTEATCPGACSAPEVVAEPRATLVSVRWRPPDCNGGAPLTEYRAEIVGEDGIVRTVHSALESECTVRELQPGCEYRLWVVACNKVGAGLPSPALHFSTAPAPPDAPETPIAYIENARTIRLEWRASRDNGAPIADYRLEMSLTNMDDSFTEVYRGPETACIVSKLVPFSPYFFRVCATNSAGRGAWSGVRDLLTPRAPPGAPTGIKHEATAESLRLHWRCPPSHGAEILGYRVQVDESDFETDGPTPEKVVEGLRPDTTYRVRVAALNELGLGDWSEEAQAATRPRPPAPPDLRCAQLVHNYIKLEWDSRGEGAVYCVEMRGSGEFRPVYRGSARSCKVKKLREGTTYSFRIRASDERGGRGSWGAAVTATTPPAPPPALRPPTVLVLAPRRAAVAWDTLDDAEYVLQCARAKDAVFKQVYAGRETQFTVEELEPGAEYLLRACAVRGGLSGAWSPAARVLVPVPAAGPRPRRARPPRALSRRRAALLMAAGFLLLAVLVAMLVQRLVEPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4X5</accession>
    <name>A0A194R4X5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chorion class A protein Ld2/Ld41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chorion protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4X5"/>
    <dbReference type="InParanoid" id="A0A194R4X5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264927" evidence="4">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="16039" checksum="5A45502695208669" modified="2016-10-05" version="1">MSPFAFLLLCIQACLVQNAYSACLGAGLGLGYADGWAGECGRGYGPGLATEFGYGPGLGLGYETGLGLGYGLAGPAAIAGPAYGGTGVGDIAVAGEMGVAGTTLVAGQVPILGAVRFGGDVPAGGVAPSPAAALVDAGATALITAVTCTKNKLWPSESVHNKCDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R507</accession>
    <name>A0A194R507_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R507"/>
    <dbReference type="STRING" id="76193.A0A194R507"/>
    <dbReference type="InParanoid" id="A0A194R507"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="8">
        <location>
            <begin position="225"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="409" mass="47123" checksum="ADA88487A09C4D0D" modified="2016-10-05" version="1">MSTSQSHVNRNFPSRSISQITNEIEEITDEELVKQVNELKHQIKVLTLENEVFERTMTRLDPTLLHGIQQALDYATRLNSNSSLNVGSFVRSQTSKLFFESLTSPSRMFASPSKISTKRAESSARVGGTIMFGTGPKINVLERSEIVSAEMEILMANLELMRKKAAKQHALLKAQLEELELRVEHIQNFREEFYKEVVVEGWDKIAQRIPAEIWVRYMNEWLKITDRKIGKFRLRTSTLNTQYSKLKGQIKIKAELSEHLRPVDFEKIKIENNECLSIIDKKLQQLAELKKMTGDANLTLSIHKKALMEQNIYLNEVISNVKRKQKQTVSLNKETEIIETQAKGLAVKLDDIKKLRNAYEVPDIMDYVHVKAEIADLKLSVKLLQNRLRILQIALSSHHRKLTKMSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R518</accession>
    <name>A0A194R518_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R518"/>
    <dbReference type="InParanoid" id="A0A194R518"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="9032" checksum="114ADB826230181B" modified="2016-10-05" version="1">MKENIVMLHVSEKKFKDMCEVNPHWTCIDYGLVTPKLGLIESSVILLNGRERRAGQKSVQENLVIRSRCNPISDHNPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7S3</accession>
    <name>A0A194R7S3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7S3"/>
    <dbReference type="InParanoid" id="A0A194R7S3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="9146" checksum="1B93C50449AB9C53" modified="2016-10-05" version="1">MHGAGLSFVINGRFQRSGTRRSKYYSFTQTLTSKWQSGLSERGDPGPGRWRRRGVGVRGARRAAAAAPCRRGRPHRRPPPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8U3</accession>
    <name>A0A194R8U3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8U3"/>
    <dbReference type="InParanoid" id="A0A194R8U3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="496" mass="55279" checksum="C7EECB45D44C3CAD" modified="2016-10-05" version="1">MSTLPRNADSLETILHFQNRDVQSQWSVVWSTAHIPGMDNAAGGAARRPALGRRRLRVGALTLGACLAMHCRIAAAALTGGFFVFMFFLILAVALLANPLRHFEVYLGQWSISGPGRAFRIIPMLDGIGMAICINAILRAIICCTVAAIAAKYVVHAASDDRLPYTYCRDFELHPYEPVLRNRRVMQYKVRPEPEFSTVGFHERAWRNFSYRSIEVLSWKPDYSYEQLNTPLVPYIIFCWVALWLLMVMEHFTFKRVITDALECALYIHSASTGTELIHGKGLNHYASGHIDARLNSENVWHSSLLLVLTGLHTGAAALCAFDDCYHPNAQVSNMASILFGGLMFSYMTVAFVLLKTALHTIFEYKGGLGLLESVDMVMSEVSTAYVCLLELAGLLYVYRGQDFISDVNVATEDNACSTRIGTQWQIIPIITLIVIILKLTQLKHSEMPRRALYAALAPLAAVVLAVPLRACYNACVFVRLTLQRTKTNSSNTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R964</accession>
    <name>A0A194R964_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R964"/>
    <dbReference type="InParanoid" id="A0A194R964"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="239" mass="26183" checksum="F1172441702DAC07" modified="2016-10-05" version="1">MAHATVSKYRELKQPNRAKMIGAMPAVAVRHERRRAEKRAGRRASTLPGRDDDAEVGGPCVRAELYKILKLTALYGVVCCSLLGIVFLVVGLVQLSPRAEAAQHRYSLMGTGGTMLALAVSLSLLRCAGIHWYKRQFEEEDDVSEQGAHQNGVADRHGHVDHKTGQVNHKTGHNDNKTGHNDHKTGHNDQKTGHNDHKTGHNDHKADHKTANEKPKLKTQASVGRDLDLAKQPSAASDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R997</accession>
    <name>A0A194R997_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LIM/homeobox protein Lhx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R997"/>
    <dbReference type="FunCoup" id="A0A194R997">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R997"/>
    <dbReference type="InParanoid" id="A0A194R997"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09376">
        <property type="entry name" value="LIM2_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000219">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000032">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049594">
        <property type="entry name" value="Lhx3/4-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="437" mass="47398" checksum="41BF210491FC0FF1" modified="2016-10-05" version="1">MGGPGSLYWLVGVMVVIREDMSANGGELVIRVGVSGRGGGGRRAAVRLTARRGAVAMLAMMYPGDEDLDMRVPPIQLEHLPEVFLSSIPKCGGCHEMIVDRYVLKVSERTWHAGCLRCAECRAMLSGKCFARNNQLYCTDDFFKRFGTKCAGCGQGIPPTQVVRRAQAHVYHLRCFACAACARTLNTGDEFYLMEDGKLVCKPDYEAARAKGGEGSLDGDAASKRPRTTITAKQLETLKSAYSSSPKPARHVREQLAQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKSSGGGSPRHDRLLDKDELKIDLDSFSHHDLSNDSYSTVALGGEEGSPAGGGAAGTVARFGAGATPPYLRAHSPPHAHYHYPPDHLVYTNIGQAMSGAGIGGTSDMSSSSSPAAGGYPDFPPSPDSWLGEPHHYSPRGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAG5</accession>
    <name>A0A194RAG5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fibrillin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13565</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAG5"/>
    <dbReference type="InParanoid" id="A0A194RAG5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000044">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000020">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000019">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000017">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000653">
        <property type="entry name" value="Putative Fibrillin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000024">
        <property type="entry name" value="Putative latent-transforming growth factor beta-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="42"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036312">
        <property type="entry name" value="Fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="42"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="13">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
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            <begin position="2086"/>
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    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2930" mass="314936" checksum="C86E657BCBA2BB25" modified="2016-10-05" version="1">MFVLRTKRAAPSGEYELMLRCECYEDAVQWPHVCRSRNSTHCCPGWTSRPNSLLCVVPICRPDCGSPGSCVAPNMCRCPNGIEASSCGGGGGLYPYSARTRGGCRRICMNGGTCNNGTCACAPGWSGEFCTEPICHEPCLHGGRCIAPDRCVCFHGLSGTRCEIDRRTGPCYTETRGALCTGALEGVVCTKQLCCATVGVAWGHPCERCADLDCPTGHLRNLATKECQDIDECAAVPGLCEGGRCVNSVGSFSCECPPGQRRHRVSNNCEDIDECEDPDICPNGKCVNTEGDYYCLCNPHFIPSPDKKFCIDGRVGSCFTYLGETGECGDRLPVPLSNRDCCCGYNMGRAWGDLCAPCPPRGSTEWTHLCGGGIIPPDWRRNDTSGGGAGGAGGGGDAQPIAKINECMLRDGICGLGDCIDKDIGYQCQCWDGAEAAEQDGNPTCIDIDECALEYCKGGTCVNKPGGFECRCPPGFDPVENGLRCSDKNECEMTGGGMCSNGVCINVDGGFECQCLAGYEATERGHACRDVDECRDNPRVCRRGRCRNTPGGYECACEPGFAPTAGGYCADVDECTDTSLCHGGRCVNSEGSFQCVCEAGYRGTAARGACVDVDECAELRVCRNGRCRNSPGSFRCDCLPGFTLSNDGRTCLDEVQDLCYEKYEDGQCSGPGTTPVTRSQCCCSATKGFKLGWGVGCKECPKPGTSDYDILCPEGPSKDNGGADINECTMIPGVCAHGTCENLEPGYKCICDPGYHPDADGICRDIDECDMHQSYCTGGQCRNTLGSFTCVCPPGTRLDAEEQLCRDIDECEGETVYTDTDSDIDRGDIPPTFRRAEQSNPCDNGRCINTHGSYECECEHGFVLDATAQHCLGEKSTALLCNNGAHNRRGSCWRRAVDGQCEGAAAGALLRQECCCGVGLAWGSPCAPCLPEHCPCPKGFAKLDGATCRDLDECMLDAELCAGGTCVNTDGSYRCDCPPGLTLDSTGNRCVDTRKEYCYTEYIGGRCSNPLQVSVYRAICCCSSLGKAWGDGRCEACPKKGTDAYRTLCISDVSGPATTWDRPYLGGPNGTDIWSHTGGGDFDSDWDVDVKNNLGNGTFDGWRPGGGLVPGQMEVNECAAFPGLCGHGRCKNMLGTFTCECFPGYEKDSKNHTCVDVNECEIVDEVCGAGECRNTDGSFSCHCRDGHRADELTKVCVDIDECAENSALCRNGRCVNTPGSFRCECAAGMELAPDRLSCKDVDECSITSGICSNGACENLMGTYQCVCDEGYAQSSVKSHCEDIDECSEDPTRCQHECVNTPGSYHCECRDGWRLRADGRTCRDVDECGEGARVCGGGTCRNTPGAYRCECSTGLLPAPPGVPPTCLDVDECTDIPELCGAGECRNTIGSFVCRCPDGYSVKPDQGPACTDDDECELGTCDCHPAADCINLPGSFQCRCRDGWRGDGTECEDVDECLTNNGGCHPRATCRNTDGSFMCLCDTGYKGDGYSCVDIDECGNDPTLCENGHCTNTPGGYECDCDVGFTKSADGRSCLDMDECATFDNVCVFGRCVNTYGMFKCICDKGYQSDSVDDLMPGFNCTDVDECKSPQSCQYGTCLNTQGSYICRCPPNYELVSDGTACFDSRKARCYGQVDLRSGTEHCRDSDELSEDGTMAACCCSVGAAWGNYCDLCPEPGSEAYRQLCPGGPGYQPVLEPVSAHPSYVVTLADIDECAQHPALCEHGTCTNTFGSFVCTCGPGRRLSEGAGAARCDDIDECAQTDICGPGVCRNLPGSYVCLCPEGYVAMPNGKECVDVRQRQCYLDWEPETGRCSAAVGVPQTKYLCCCSVGRAWGAPCEACPDKGSQEHMALCGEKPGEYINPMNPNETRPINECDIMPQLCKPGSCHDTPTGFQCGCDHGYEHDNTSHLCRDIDECQGARPPCRGLAQCVNLPGAFECRCPAGYRLTASLDECEDVDECADQRLCEHGECRNTIGSYRCECAPGYTLRENACRDVDECARPRPLCRNGTCENRPGSYVCHCDEGFKPGANNDCIDINECREGGMVCRNGRCRNTVGSFRCECAPGYVLSPDARNCRDLDECAELPAPCGTEGSPACTNTNGGYECSCGAGWRLAGRRCVDRDECRDLPYACAGGDCHNFNGGYRCDCPAGWRFDQASAMCVDERKELCYEQWDAGRCHKARPLQLSRPDCCCSEGAAWGRYCERCPTPDSAEFLRICQGGMGRPNLTQLRRSLVRRTPFECSNDQCRCVQDLDECKVRPDVCKGGHCINTDGSFRCSCPAGYVLDGSGLVCVDADECAQDPRICGNGTCTNTAGGYECTCNLGFTQGTEQTCVDVDECAEGRAACSFRCHNTPGSWRCTCPYGYRLAADGAHCRDVDECAADPAPCPHACENVVGSYICKCPEGYKRTSAPHDAADACEDVDECAEQRDRCAPGVCINTEGGFLCDCDAGYQRSDDGHSCIDRRTGMCHRSLVSGRCTPEPWPRFMSSTPALPSQVTKAQCCCTLGVAWGPECELCPAAGSPERLALCTRTNLGGAGGGRGRRRLPRHRRVRARLPHLPADLHQHRGLFRVRLSGRIREARRRLHINECQEEGLCPAPGKCVNLLGSYRCVCPRGFRLDVAGARCVDRDECGDGRCQPCRNYAGGYRCDCPPGSVRAASGGCVPQDACAEGPCGAAPCFPLGAAYRCGCPAGYGWDAGHGVCLQLGGGCAGASCLFGCTALGGAYQCGCPAGYALVGAGHCLAALDAPGDGDIGDAPVFPVRDQYRVGGDSDLISTEGCFSCKMNGRHRRAPEEGIVFANGTTYVRRRRRRSRRRRSLLEPEAELIVVKVTPRQTWGRAPLLRLVPAEGGGRPHYRIAYGDDDKDFVLSKRDGAWALRLRRHLKVQASLERQLELEARFVPAPQPGRRRRQLAEAAPAPLRLYVSIHIAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAN4</accession>
    <name>A0A194RAN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDB1-and CUL4-associated factor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAN4"/>
    <dbReference type="FunCoup" id="A0A194RAN4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RAN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20913">
        <property type="entry name" value="DCAF15-CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038914">
        <property type="entry name" value="DCAF15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047319">
        <property type="entry name" value="DCAF15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541:SF1">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14939">
        <property type="entry name" value="DCAF15_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 15 WD40 repeat-containing" evidence="2">
        <location>
            <begin position="57"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="788" mass="89228" checksum="004BFE1E8F2BD400" modified="2016-10-05" version="1">MDSLAEESENTFQFNENECNKTNCNTFKNGSEHSNNIVHKLFNREIYGSTSRKSNEKSRKMFEKIPPRLRFCLMDIVPISYLRKHVFMGFSQCGQFLLSFTYSCNNQVYFRESSKFKLHFLSWVPGKVVKPVHSVPLFGDDCVDSKVTISMAQWKHNPGVLVVYGIAFSCSERSYLSVIGVPRLGCKKCAAYSKEEDDSHWGNRCLEHNFAIHTKFFCTSDSSMYEPVVQLAYSNQIIIYTDFIHILEIDFVDPDQDRNEANDYNKFALDRDDMNSIDTNPSTPASDVSAAFQSPKYQNNVVQNILADFSDLEAEPYQMSRPVHLSDMMGQELCIQASSISHNLVEEWEGPSPSIRTLISPPLRSPRRRPAESMSRFNETHRTIAEKAYEFVEETDTKCEKLSIFRKRRLADKKYEFSEDNNENIVPFRVLRSNRKYFIGSASKSQAKRAKSPPTESVVLRAHNQISRPTSPTTSCDLKNPGLSALESDRNSESEYRVMEMLDDGSLKTVAVHDNTSKTLSDIPVSLQDPYLVHSENSKCSKFFTRYFVESDDEITSIITDSEDDCMSGYHVALHLTAHGARYVPLQAVSAGAWERLPARRTVRATQRSLDTELLCNEVCGRLCHLRGIKFIYCFDWGCHVIDVCHSSGCLSGLCAMWLWASEEGAGDAAGECDACRTVSAGCLSHRRQYAAECLFVWDLVTGVYRTERVSMTEDDSQEVSGAERARELAKRLGPINMPPGNENRLLTTLTGKSLKRLTDVDNCIEITKNHPDSSESESSSEEDSDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC67</accession>
    <name>A0A194RC67_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC67"/>
    <dbReference type="InParanoid" id="A0A194RC67"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265076" evidence="2">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="426" mass="49257" checksum="3332DCAA59C2E2D9" modified="2016-10-05" version="1">MTVRCILIATFVILQLSNIVKCSDNLENVDEKQTFLNVNNKYQTFPRTFSDDIRKDLKTFQDESEIKDTDADDFKPRIFVRGCGNSLCEFFKNHRVIRQAGYSTMYPQVPTSYPYRQPNNTYQYNARQPINPYGNNSYPSYSKPVVPIIPYQNPAINDPVYNSSYSHFPNKNISNNNYQNSRHTYPPSPRPPNRQPLPYYGGNTTSVGLNTSYPFNINRPTNSFGNAHKQGYPNPGSNLTNYNIYNNRTQGGNRYPNNTYLQPRPLPSGQLINNSRPNYNGFHTYPTSNFNTTFNGYQSPNGSHYNGKSTYYDPQRNFTYRPPVTPNYQNYGGNNSLGSNKNNFHIPFAGNKVYPTYNNNTNPYNFNQTVRMDPYQRTSTNRPQTTYSANIPQYNAAMEPNHFYYVPNNNGSQYDSRRHPPERFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCP4</accession>
    <name>A0A194RCP4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_09072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCP4"/>
    <dbReference type="STRING" id="76193.A0A194RCP4"/>
    <dbReference type="InParanoid" id="A0A194RCP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="517"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="71286" checksum="FC484E5EB07242AE" modified="2016-10-05" version="1">MSNYDDDQSEDGELARSPIHDEMDFSLSDEDRDNADSLVIKPPQAVIRPSHRDKRNHKRSGKERYKEVTSRKEKKHFYRERDKSDKAKRGEIPKNLEREDMTKEYYREKQYYREKDPYREKDMREKELYHEREMYREKDVYREKDPYREREHYREREMYRENPSYREAPRQRDVYRGKEIYKEKDVQREREMYLSRERQKYADNERKRYETEKIESRLRVIAEENRPNHNEKENRDRTSGDKELEDLRTRLLSKRISKELQNQDKKQSDYTDKESKSDDRQRHSSSLDRHQQERRKRLLEAEKEMEKRKHESRTELEARREERRRRGKKRSVSPDDVANKKKRQQSPNYDSVVTVSDASDTDMKSYSVHSEPEEGEHSHSETDEESTTDSDSDAESKSADDDDDNEEKSEKEDRSDKEEDVEKTRHKSKSKSKSPSPKSVHRSPSSHGSRRSNSRSKSRSRSHSFSPPPVGENGKASTEEEKVEDDDDEKLRLKEEAINSLPPYFPALQGCRSVEEFQCLNRIEEGTYGVVYRARDKTTEEIVALKRLKMEKEKEGFPITSLREINTLLKARHLLPEEGCARGVTPLQGLTTSIHGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCQ8</accession>
    <name>A0A194RCQ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_10875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCQ8"/>
    <dbReference type="FunCoup" id="A0A194RCQ8">
        <property type="interactions" value="1123"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCQ8"/>
    <dbReference type="InParanoid" id="A0A194RCQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="472" mass="55325" checksum="EAA2704C9CACD385" modified="2016-10-05" version="1">MSFTFIKGLFLNPAKLSITAFIIIIAELVLNILIVERVPYTEIDWKAYMQECEGFLNGTLDYSQLRGDTGPLVYPAGFVYIYSMFYFLTNQGQNIKLAQYIFIGIYLLQLHFVFEIYKKTRKVPPYVLLITILTSYRIHSIHVLRLFNDPIAVLFLYIALNYFIESKWNLGSIFYSLGVSIKMNILLYAPALFFFYLVNLGLKDTIKQIFLCGLIQLILGLPFLLVAPISYLRGSFDIGRVFNHTWTVNYRFLDVKVFENTYFHITLLAIHILLLMIFLPMCIQYFKSYCRLRYVQKQVQPQIDAKNVENKRKAKMMKEKLKVQENEEKLTKDQEEFLNSFESMLQKTSNTNAKKKKVADESEKLHYSINFDIISQLFILPMFLTNFIGVVCARSLHYQFYSWYFHSLPYLLWSTNLSVIVRFLILALIEFCWNTYPSTNATSAMLHVCHLIILYNIYKKTSTELKVASKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD68</accession>
    <name>A0A194RD68_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD68"/>
    <dbReference type="InParanoid" id="A0A194RD68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="10119" checksum="79CBB580DD444983" modified="2016-10-05" version="1">MEDSVKHCTESTIYSNNTGKLHNKRGRPVKSKNIQFGPQPPSIISQLLRKNVENIIKHNNITDEQIPNTIEGDNKNEDTDFLCIVCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDL3</accession>
    <name>A0A194RDL3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDL3"/>
    <dbReference type="FunCoup" id="A0A194RDL3">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDL3"/>
    <dbReference type="KEGG" id="pmac:106710344"/>
    <dbReference type="InParanoid" id="A0A194RDL3"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="284" mass="32651" checksum="7AE143B9D0261380" modified="2016-10-05" version="1">MWEKILFCVSMCVLTFSFLSKKISYTESSKFSFHLKFFLYYFLCSLLAFVIWPLFLFRPRNVKNSRLAASILKHITKLYDLKWELRGGDILSKDRGAVIVSNHQSSLDILGMFNIWEVADKLTAVAKREVMYVFPFGFAAYLAGLIYIDRNNPKRAREQLNMTTDVMVKEKTKIWLFPEGTRNKDYRSLLPFKKGAFHMAVAAQVPIIPVVFSPYYFINNKQGIFNKGHVIIQCLEPISTKGLGPEDIDGLVTRVRDAMSTVYKELTKEVITNLPSDYPHTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE33</accession>
    <name>A0A194RE33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0368 protein Cxorf26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1168"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RE33"/>
    <dbReference type="InParanoid" id="A0A194RE33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="21226" checksum="DDF4287FE3557CAD" modified="2016-10-05" version="1">MSKSNRHKKTTLACPNIEDVLSRPAEEFDNDETLEHLWAAKAMEHSDIYFNVLCSVDTRWLRLTQHDDLIYNHFRQDFPDMDVKYINENVLKNNVNKSRWRMFCEKFKNIVEDYSFGTLLRADTNGDYSEQNTILVPRVQFYAIEIARNREGLNNEVKKRCKCASKLSMEAQEHTQEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REA9</accession>
    <name>A0A194REA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein ovarian tumor locus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_08173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REA9"/>
    <dbReference type="STRING" id="76193.A0A194REA9"/>
    <dbReference type="InParanoid" id="A0A194REA9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20380">
        <property type="entry name" value="Tudor_TDRD13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049770">
        <property type="entry name" value="OTU_Tudor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="529" mass="59891" checksum="36B71C5C3849FC5E" modified="2016-10-05" version="1">MSNPSEWGGLIEISAMSHLYRRDFVIFEANKGPQTKICNGYGNTIYLFYSPDTKHFDAVYTKEFINTSSFCQSLVYEILYDGVYKIKDLPYAVDKMLHDKIPSNHIEYFMSENVERRKKQKDRAKIFIETISDDDKDKNNNAVALKCKHHTEDIERGSLLKESLSIFVFNRSLIQLENVCINCLNVNSAKDLLDNGITPFPYKVAKALDPDIYRNIEFDVWSELRREFRYGARYSDGTTLQVGVKCLCKLQTDQSVPYHCHIQEMSPDGGPCLVFIEELGEKRVVSYDQLEPLPIEEIRPWAPPYRFSRTSSQFLSLSQMLQQIGNITRKQGIKGRNKKGDDMKSTEKNPMKNNEKIEPQPPFKRGGNHQDGGNQNNNHNQNKGHNNMPNKGSNNRRNSHNERGGAPQVYGVVGAGGAEGECVLEQPLLSVPYCQYPPPLYPLPYYPMEDPAMMGMMGGMGYVGYDEGLEYGPPVQHYYAAPHYPPPAALPPAAAAPPAPLPHHLAQHAPHAHPPHPPPPHHQHHAEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RG49</accession>
    <name>A0A194RG49_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein C20orf11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RG49"/>
    <dbReference type="FunCoup" id="A0A194RG49">
        <property type="interactions" value="2174"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RG49"/>
    <dbReference type="InParanoid" id="A0A194RG49"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="231" mass="25879" checksum="4DDAFAEF781A96E3" modified="2016-10-05" version="1">MSFENPTNNGNNQEEHKHGKPEGYQISRTDMNMLIMNYLVTEGFKEAALKFQQEAGLQEPALCSSLDERILIREAVQNGRIPEAIAMVNSLHPELLDNDRFLYFHLQQLQLLELIRAGRAEEALAFASATLAEAGANDRAALAELERSLALLAFPDPHSSPFADLLLPAHGQKIASELNAAILKMENQEYTNPKLCSLLRMILWSQSELDKHNVKYPKMTDLANATIEQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGS9</accession>
    <name>A0A194RGS9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Esterase B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGS9"/>
    <dbReference type="KEGG" id="pmac:106708937"/>
    <dbReference type="InParanoid" id="A0A194RGS9"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265178" evidence="6">
        <location>
            <begin position="22"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="211"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="733" mass="80431" checksum="CCB032AA7EDE44F3" modified="2016-10-05" version="1">MPATQWTAMLVLQLLAHNALCGYGTLAAIADLSDHSAHADLRDHSAHAEQSDHSAHANQSDHSAHADQSNHSAHADQSDHSFHRDQIDYSDHSGHNDHRDHGDHSTHSDQSEHSVHSDHGDHNSQGDHSAYGNHSTLGDRGVLSDHNDYGNHSNHGDHSDHSAHSDHGDHGDHDARGEHSVAGGHKSHSVQSGRSVRFGVRLVERSEYIHATTSSGSIRGRLARDGDYFAFLGIPYAAAPTGLLRLKAPQPPPAWNGTLAAERTVVCPQQGVGEEDCLVLNIFVPKIKAKRALPVLVYIHGGSFRYGAGPTRGAGPIVEQGVILVTINYRLGPLGFLCLGIDEAPGNAGLQDQLAALRWVKSNIKHFGGDPNGVTVYGTDSGAACVELLVLSKASTDLFARAVIESGSGGATWAIDDRPLCTAKNFAKAFSVSELEHPLKLLELYQDVPASLLTRVNEKFANTFTDGRYGFAPCVERPFEGVQSIVTKPPLEILRKESISEIPVMFIFASLEGLFLKSREYYTLNYMNRMEANFAEFLPSGLNFDNQIKRIEKAAEVRRFYFANATIENNKLGYLRYFGDSQILRAVVGGAEAHARRGRLVYLMEFAYGGGLRARDPLYASVVAQGAPAPAGHAHFNAHVILNSTVQSDSDQLAIERAATLLCNFVKYGEPTPNMTEALPVRWPRLRPPLVPYLRLGDDLQLLEAPYSGRIQFWKQLFYDFRKQISDYEPYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH13</accession>
    <name>A0A194RH13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_09248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH13"/>
    <dbReference type="FunCoup" id="A0A194RH13">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH13"/>
    <dbReference type="KEGG" id="pmac:106710641"/>
    <dbReference type="InParanoid" id="A0A194RH13"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF7">
        <property type="entry name" value="RH09188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="85"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="539" mass="58504" checksum="52AA9BA0F5840E6B" modified="2016-10-05" version="1">MVLLIFGYALSYQRRLRIVKIQSDGAHEAMLAESRKPQIKSKQTHSQEEYEALQSFLRSISSTATLPPYVKGETYSSMRGVFNQCLITCAVLVLAAGAGHPIGFSAVALPQLQNENSSMRIDEEMGSWIASIHSAATPLGSMLSGPIMEAIGRRRTLQASTFPLVLGWILIGTAMHHALLLLGRIVCGFAVGIMAAPSQVYLGEISEPRLRGLLIGTPFVAYSLGVLYVYALGGALPWRSVSFLCIVLPSLAFVVLCLSPESPTWLARKGRFHEAMAAMGRLRGNPEIAQRELHELISAREKEKARGEETIRFFATVSRAPVLKPLLLINAFNMLQILSGSYIVIFYAVDIVKEAGGSLSPHMVANASACTRLGVTVIACILLLKITRRSLVMVSGVGTAVCTLALAFLLYQDAGSGIITPVLILGYVAFNTLGFFLLPGLMIGELLPTKVRGLCGGYIFCVFNAVLFGFTKLYPVMKNSVGMSGVFALFGFAATLATVVLFLLLPETKGKSLLQIEQYYQKPNILWVTRKKTTDGQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH14</accession>
    <name>A0A194RH14_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger matrin-type protein CG9776</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH14"/>
    <dbReference type="STRING" id="76193.A0A194RH14"/>
    <dbReference type="InParanoid" id="A0A194RH14"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055309">
        <property type="entry name" value="Znf318-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15577:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="295" mass="34135" checksum="2FE27A5748B7CEB8" modified="2016-10-05" version="1">MSRDVSRKSGYDRGGGWDRNYYRNQMQRKRSRSPPSREGKRRSRTPQKPKKDILDDNILNEISKLPEPNELWDNQFQEGFSGNAPPSFTRDGGNYQRNYQPSYPVNYENFGGAMPPMPPGSSGWSQPASAPPAFNNVEEQIKKEAAIESEMRHQKAALSKQREDCMKKATILKKELETLKEQRSELHSDSKRSPSPDTKRFLKENTKLQLEIQNKLKTINNVVDMLNGIIGEEVDKNEEDNSGERGSRRKSRSPSTKRFNYVYYDPEMHWCRVCNEFPATAKDYLTHLHSPTHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHJ9</accession>
    <name>A0A194RHJ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHJ9"/>
    <dbReference type="FunCoup" id="A0A194RHJ9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHJ9"/>
    <dbReference type="InParanoid" id="A0A194RHJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013198565" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="134"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="362"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="438" mass="50811" checksum="9217A5E6A7D76E21" modified="2016-10-05" version="1">MKILIFFLCVAFSRAKIEQQRVGPGYDCPYCQPEQVHISFGEKTNDIVATWSTFNDTGESRAQYGVGQMDQEASGRSTLFVDGGHERRAQFIHRVLMKDLKHDTTYVYHVGSEFGWSEEFWFKTPPVGEDWVVRAAIFGDMGNKNAHALSYLQDEAQRGHFDLIIHVGDFAYDMHDDNARVGDQFMRQVQPLAALVPYMTCPGNHEEAYNFSNYRARFSMPGGAESLYYSYDVGPVHFVSISTEPYYFLQYGLKVLENQFRWLHRDLSEANREENRAKRPWIVLYGHRPMYCSNSDDIDCSFEYTRKGLPIWGSYGMEPLLKQYGVDLVVWAHEHSYERLWPVYDEQVYNGSLHQPYTNPGAPVHIVTGSAGCQERIDPFVSKPPSWSAFRSTDYGYTRFFAHNKTHIHIEQVDVDLKGEVIDSFWLIKHRHHPFYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHN2</accession>
    <name>A0A194RHN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">28S ribosomal protein S34, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHN2"/>
    <dbReference type="FunCoup" id="A0A194RHN2">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHN2"/>
    <dbReference type="KEGG" id="pmac:106708829"/>
    <dbReference type="InParanoid" id="A0A194RHN2"/>
    <dbReference type="OMA" id="NPQMKVH"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="195" mass="22526" checksum="E965625B5961E002" modified="2016-10-05" version="1">MTTTVIKYVGRTTDFKGKTLWEIVGSLKNLGVGRIIVRSVFERYPEPSFMKIVKVETCPDEERRRVRVWVEKTFRGKKLEKLTEIYRTSYKPDYKLIPKHEEANLLKSIKDVHDSPDVILPRTIEMPPLMKKFIVKDHENKGMEILKEYVMPLSYNTSPNRVARIAQGDEKPTVQFTMGLGKPASPSLYEGVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI34</accession>
    <name>A0A194RI34_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI34"/>
    <dbReference type="InParanoid" id="A0A194RI34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11264" checksum="345763521E65891D" modified="2016-10-05" version="1">MAAPAGGCSGLRRRARTYDCNVLLVCGAPMRKLTLVTRAANKPHRNAYSCGPQPCRLRVLAPPARGGRCVRHKGTLKYCDWITQGAESAPVLRNANASRPHLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIP7</accession>
    <name>A0A194RIP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIP7"/>
    <dbReference type="STRING" id="76193.A0A194RIP7"/>
    <dbReference type="InParanoid" id="A0A194RIP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="134" mass="14123" checksum="5E5C9D56C05A7C64" modified="2016-10-05" version="1">MQAMSASAGAPQRSPFAIQELLGLSEGREAREGREERERERYEGEAAAAVSRYARGPFAPQFPLPASVASRVAYAAAFNAQAAVAAAFLPGPPMLHAPPGKSNLSLVLATLCGASPSNHSTPDSIRLLRKIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIV5</accession>
    <name>A0A194RIV5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIV5"/>
    <dbReference type="FunCoup" id="A0A194RIV5">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIV5"/>
    <dbReference type="KEGG" id="pmac:106707876"/>
    <dbReference type="InParanoid" id="A0A194RIV5"/>
    <dbReference type="OMA" id="MFPKRRN"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="188" mass="20512" checksum="967A9035F8ED7B21" modified="2016-10-05" version="1">MDPIAILQNRIEQLEAKLGFALNNPADGQQEDSATANLLNTAQSINNATAGHEKLSEGMQRATELNNYTDPNFVENMQQNNLKMQEVAAAESVIKHHCHCMHRCKQATPILESEAIQQVPQLQKTVDKMHAEAAEVKAESDVVSHGIQEVAETCGTAASKAAEGLAEVAQKVEDVEVKTFPKRRNGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJX2</accession>
    <name>A0A194RJX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJX2"/>
    <dbReference type="FunCoup" id="A0A194RJX2">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106707938"/>
    <dbReference type="InParanoid" id="A0A194RJX2"/>
    <dbReference type="OMA" id="NIKCFAN"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265272" evidence="5">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15094" checksum="9EBC814C424B2ED0" modified="2016-10-05" version="1">MKYFVVFAICLVAVQALTDEQKEKLKKHRSECLAESKAVEEQVDKLKTGDFTNENEDLKKYTLCLMVKSELMTKDGKFKKDVALAKVPNAADKPTVEKLIDACLANKGSTPQQNAWNYVKCYHEKDPKHSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL67</accession>
    <name>A0A194RL67_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger protein on ecdysone puffs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL67"/>
    <dbReference type="STRING" id="76193.A0A194RL67"/>
    <dbReference type="KEGG" id="pmac:106709086"/>
    <dbReference type="InParanoid" id="A0A194RL67"/>
    <dbReference type="OMA" id="NYRPNGG"/>
    <dbReference type="OrthoDB" id="6354489at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF18">
        <property type="entry name" value="CIZ1 ZINC FINGER PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75649" checksum="0F1251D115EBC11F" modified="2016-10-05" version="1">MSSRGRIYGGYSGRGSYNNRGSGYRGGYRGSSSRGSYEGGRGGRGGYSSYNNDNRYNNSNSTRYSTGRDRIDDSYKKPYRSEASASYTNRDYGRSGSPDRKRMRMEGSTSDRRSHDGGGHYGGSYGGRQDSYSGERRSFGGEDRRRSPTRDGYRKPSGMGPPREPARMSVRPRAPRRSYRGRMLRSRASYRGAPRSRGSFTSRRFGERSLGYTRAFRSIKSRSSIKSKDEASSTEEDWDADEKEEEAIEEKKEAKIKSPKVEAEGSEGEVGEGGEDTDKEPDAASDGEPDNSTASYVLLSCVHCKEKCATFVGYARHLLSNKHRAAMSAVARRHKAQLLRMRVAQRGAQRELEASAGAELAARTTFCMVCRLNHRTTSHAHSLTDTHRAMRRFLMPFCRICRIKFRSPMIYEHHICSLEHLKRKANQTARRVSPKAEASGDEGMDVDLDNFMTLDSVGDVDEVEDDDSGGEKKDESPKKPKVEINIGSEHIKKVEVLWCELCRVYLPRGAGGEAGGAEETEALRRHCRMRTHLGRYVQHRDTRTLRRHAERIHRQLHQQKEDEKAEAGEDNTDDKAMTEKSESGIDKKNLENGADITNAGSEDKLWADVDKDIGELLREVDPQGNEGSDDDEDLGRYDKFRKSDKKSKIGDGEEGDVKAGDISKEKTITEVNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNU6</accession>
    <name>A0A194RNU6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNU6"/>
    <dbReference type="InParanoid" id="A0A194RNU6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265335" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9636" checksum="51DB6A7CE679AF52" modified="2016-10-05" version="1">MGPREMGPRQMGPRCLGLRAGPTRLWAWLAVLAALGRTTAYTDTEEFLSDLDKPGFAASVRAPRQPHHQPAVERGQTERALHRFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPP4</accession>
    <name>A0A194RPP4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plexin TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPP4"/>
    <dbReference type="STRING" id="76193.A0A194RPP4"/>
    <dbReference type="InParanoid" id="A0A194RPP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plexin TIG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="8887" checksum="D12DF9F71ADB4BEA" modified="2016-10-05" version="1">MAFTPWKCRINVNGKEHVIIATLLVDTVYCESFEFKNESEEPSVSGSVTVLWDYNKAFDGNLPFKVCRCDLDSSCIACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPQ8</accession>
    <name>A0A194RPQ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase subunit s, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPQ8"/>
    <dbReference type="FunCoup" id="A0A194RPQ8">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPQ8"/>
    <dbReference type="InParanoid" id="A0A194RPQ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="202" mass="22812" checksum="368C770B177635E3" modified="2016-10-05" version="1">MEGYSLIQRLGSLTRKVFLPQKGQTRSFWEYVNMMFNKPDTNRIKTVGPDRACAEWVLRNGGKVTWADGKKQTDYNLLPPEELKSQKLLEIDGSDSSISHYGFSHLDGCTMLKKIILHNNKYIDDRALKGLEYGKDVLSHVQVSKCVNVTDLGLKEMIVLKNLKTLVLFDLASVENLAECKQYLGSGLPKCEIRGQVESVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ82</accession>
    <name>A0A194RQ82_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aquaporin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ82"/>
    <dbReference type="FunCoup" id="A0A194RQ82">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQ82"/>
    <dbReference type="InParanoid" id="A0A194RQ82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF270">
        <property type="entry name" value="ENTOMOGLYCEROPORIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="265" mass="28940" checksum="8FEB6C03E4CF3032" modified="2016-10-05" version="1">MTVPAGNIVVGIIEDLSPKDHRVKIRNRLLIWCSLWWRAIFAEFLSTMFLVLIGCMACIPSDEIHPNPPIYGALGFGIAVLFTVQAFGHISGAHMNPCVSLTAVLWNKISLSLGIAYVIAQCLGSIFGYGILMQVSPTDLISNGICTTHPHEKYTVLQTFGVELILTSSLIFLVCAIWDPLNSNSQESISLKFGFVVAGLSIAGGPLTGASLNPARSLGPALWTGVWTFHWVYWTGPLVASMVVALFYKYTWLKPSLDVKVNLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSK8</accession>
    <name>A0A194RSK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein lava lamp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194RSK8">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSK8"/>
    <dbReference type="KEGG" id="pmac:106721150"/>
    <dbReference type="InParanoid" id="A0A194RSK8"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2081"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="671"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="830"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1941"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2103"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2172"/>
            <end position="2220"/>
        </location>
    </feature>
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            <begin position="2290"/>
            <end position="2352"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2383"/>
            <end position="2455"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2496"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2730"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
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        <location>
            <begin position="349"/>
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        </location>
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        <location>
            <begin position="398"/>
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        </location>
    </feature>
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        <location>
            <begin position="441"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2898" mass="334992" checksum="26738003A2F48D44" modified="2016-10-05" version="1">MSDNKNVDNRPEKDQVESFDTNLAVTTDVSNVVSSVRNVKHSTSSERQNKVERAQKCLENAALVSKRIKEQRKATAELLGRPFEDDVTDTASEMASTMSERTSYSVATDTSTTLSVQDALNIPGISESLANTLKQKELLMERIKQYKEISKRPMRKSLSVKRELSDTTVVQEVKKSADNSDVAKLINTIKEKENALSVMQVKIKALETTILDLQEKINEKDQIIEAKNKATTLITDSLSKKEKDTLDLLEDTRQQMTKMQSNFIAMETEWKDEKQRLLDQIGEKDEKIKSLEEANTILENSRFEISIAHSKLAEELELKKEEILKLQEKIETMTQKSVDELSSGTLQSGDKEFTEEKGTLEISNMEELTKKLELLEQINCQMRQTNKDLENQLMSLNPDQKATSTSPAKRTPASPHPSRKGGRSAASKSKSPWRGLSTDRGQQETDKSKTKSDTVKQDMVVQSLNKDILDKEYLLTQKDELISKLKLENSEKENIINNLQALIETSKCETNKVDIAICTDPLESIVTSEAHEIQQGEVIENIPEDVQTLKEKLESAQSQIDQLNEEIDVANKNMIKVKSSYKIKLKQLQKTIDSFSKVSDANAEIVKLNEELHQLSQKVAELEEEKGNLQLHLVDYDSSRLTDSDIYKKLVEMETLADSRLKSITLLETQKFELVQELHVLQQKNDEMEDKLADMAQLQNDHVCSEIKSVQMEEQIDELVASKKELELVIENLKLDKEQSTKTIKALEEEKDHLIQKLENYMQENMELTDKFEKLSAEKVSSAESIEMVESLTTQEKLELEEYNRTMAAKQDDNHSEFKMNEPGEGDENITELIKQSAELRDKVELFTQEKQEVLEKMNKVCAENEDLQERIKELKTHCDNLTKNIDVLSEEKNTLQLLNEELNNQIELLKHERFEIMKESVEIAKPASMEESTEGISTETSHDDKLVGDKSNNRSKSVKQLTKDILKLKGTIKEREAEIADCQMKILSLEEQQEKQKELMQNITILDNKVKNLTEENSQLKREIETAQKDVESEQQYKQAHDVLQQEIQKIHQEYSMAINARDTRINELENLLVEYEKQMFNYGNSLQQKDKETAEYINQITKLNDVSQKLKSTIDLLEEEKAKDQNAELVKALNKDIMMYQKKLAECEEKLRGLEDEKVQLLSVKSSLEVKANDLELELKNLQEALTEKQAAIKDLQTQQQKHDGELSSIMLQAKERDEEIHEIKLQLRKESIENEKLRNEVSKKVNETEELKKQCNELKQKVNVVSHDKENYNERQTILETKNKELMDKLKKLAITLKRKTSSYNDLELDYNDKRKELEDKNLQVQDLLSKVEVIPQLEDKIKDMEKEYDNLQNEKLLLEQRCRNFDQLQVENETLHKNHVNAIEEISKLHTSLDTLNKELMCARDDNENLKNQISALNNKLVEYEIEQKNSSNLSTKITSLESDLSQKQALINELSVQLESQKEHLSQIQFGHDAKVQECNLYIESLQTEIDKYKNRICRLEESISTMENRRHSLERKADQLDNQLQEKQKAYTEYTHQEDELVNRLAVLIDHDRVVEKQLHVIEHENRELQHKVQHLNEEILRLKNAYLDLQNNYTLMQTKAAKGEAAESELVICQSKVYELEASLKHITNEYQTILAQKKVDIEELESEFNTQIENAIKEKKILSENHERLSEHVTQLERKLQEYKDTNVNLNLNLQEISAVNQNLLEKSNERKSTAVDYTDQYVSEINKLNAVVNNKNQQIVDLENDIKALQTNKVAKVSELEGRMAELSSNLARSEKEIELMSTELKSIKENNEELQMLLLQKDDQIKQLTDKSKVVFEMTIPKTEGMTISSTIEQVNDQSGVDLATLESQIVPESFVAEVKPPKKITESTLVQSSHSGGARSYQEVQEPVIVAKKSYDCYKKDSDMISEDPFCSQEGWGFEGEETEDASAGYSYLNEQIEKLRKENDRLKGELDNTNVKLSKVLKISKELKAKNELLSNELKISKQLSDKSILDTAIESELSSNIEVLEKQIQDLNTELEREKREKEALRKQNEIFKDANDRLTEIKEKLDTEIELWKFKCNQANDKISSLQWTTEPKESPAPEIPTSRKSKPISEEIVKLEQENEELQSVIDELNDVNKKLTDQRDEFSNEVQRLQEKIQENRICDNCETLQRQILSNEDCITSLRNDITNLNSKVKEFEECYKNVSIKYEELSKLNEENQNQYELKTQDFIAKISTLDKELSAISTLKIEADETINLLKSELEGLKYELLLKKEETSNIKNASEAFAMSEKMSFMEVKCNEMSNNLEYAKEKIAHLENENLELKQRIQDYEKQTEELSSKIKHLNTENDQLLSTVAELRSSVSSAVDQRGYEIAELWKQHLTQRENEFQRIEHELRTELTAAETKYEQLLDNVQSSTQDETNNRIVMEQLNSLQSKLQEKSEHLTSLQNKYADVIHQLDMLRSETEDEKLILENKMLVQQEEYEKTIKELTQVSDSKSLEFESIIKNLESEISAMKNINDNLNQQILELRSTFEVKIQELGKQLQIKETEIHQKSQDYTIALSQRNEEFENVRKHLIEYEKKIEDLTYEKEAELAVLRLKMHENKEQHENIQKQLEDEKNSLSEALNTKIIECTNLNKQVHDLNALLQEHATKSIEMQEALENQELEIVSLKDEISNMQDLMRSSSSKIDKHVSFASDTKQTEESDKIARPYNKDLLDAVPRAELDIALYMLHQRDVRCEELTMELTQLLEERDTLQLRLSDSLRALEDLKSKSKATEGVSMSPGQDSITELPSFTYEKEQRIVDTHRAHTSRSSSISDYDGEKPKLQAKLTELRSVKHSRDVTLRQDSEQRQLGMRLLRRDVANLPPEALEELTQAHHTLSRDSQSTSTVLLNWLRGKSTPKVVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAW6</accession>
    <name>A0A0N0PAW6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine-rich protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAW6"/>
    <dbReference type="InParanoid" id="A0A0N0PAW6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="416" mass="46230" checksum="49CAFC14A09A025A" modified="2015-12-09" version="1">MYEPSRPKDLGYDLLPADAVNTLTDLGKAKRALLLEAVSFHPSAAPAYKQRATAAPAYKQRATAAPQRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRACLQSARYSRRLSTISALQPRLSTISALQPRLSTISAPVQRLSTSSAPVQHLSRAARQCSTCREQHANAAPVAEQRASAAPFDKQRARIALANELVSKHSMPLLQTNSSVEDAGRTSPRTVSFQERPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB11</accession>
    <name>A0A0N0PB11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pancreatic lipase-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB11"/>
    <dbReference type="InParanoid" id="A0A0N0PB11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="329" mass="36132" checksum="F11077D92A224597" modified="2015-12-09" version="1">MNYLVGMVVGYLSLLKASGQQQGGLLENLGEGIQQQIRPIKQPIDESIAYVGSAGCAHVKKLLGVAYEQLEGVREPDLNSLSLYYKTRANSKVYNISVAAEAITRARAFNPQRNLIIFVHGFIDDPTKDSFKNISEAFLRSGETSVLALDGSPLIHWLYLRATTYVQFMGRKLGEVLAAMVKGGTDPASIHLIGHSLGSHISGFAGKTLLKLTGRRPGRLTALDPAGPCFTHVDADLRVKDTDADYVDCIHSDSGVYGMKDPIGHADYFPNGGNSQPGCLLQTCSHSRSWLYFAESLLERTSFAARRCASWEHFKKDQCDDEVRLDMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB25</accession>
    <name>A0A0N0PB25_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB25"/>
    <dbReference type="FunCoup" id="A0A0N0PB25">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PB25"/>
    <dbReference type="KEGG" id="pmac:106718351"/>
    <dbReference type="InParanoid" id="A0A0N0PB25"/>
    <dbReference type="OrthoDB" id="6419934at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039147">
        <property type="entry name" value="ASB17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="341" mass="39543" checksum="1F7F43FBF1BF2F18" modified="2015-12-09" version="1">MDAFMDYYFEKVFSDLDRDSLNERYKRRELVEYFNSVISGCAKGQNESDNVTCKNFVTSALRYHNNCKSKNGDVCLMGKYHNLLYIAMKLSFDWSLQDNGVVAALLDELYACERTFERIFLGAIFGTSAPYFLAGWKSDFMDREENVSALVFFLDHATNANLEFKEGNKSYRFIDVPLESCGKASPVRVVIQMGAAEILMILLRFGARITSDHVSTNPIESILDRLKEYNRKYPYELVTCLKLALRAVPRLHLTVDKTAFKHLELPDDYNYDRKIALEKYTEILEDHLLPCSRCGLKPVELKHLCRCLIRQMLWKNFELPFGIHKLPIPMPLKKYLDLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBA8</accession>
    <name>A0A0N0PBA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461071">
        <property type="protein sequence ID" value="KPJ09866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBA8"/>
    <dbReference type="InParanoid" id="A0A0N0PBA8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="59" mass="6864" checksum="535BEDB8EBE6DC9E" modified="2015-12-09" version="1">MEKTMSVVSLRNKIRKEDLIGKRLDTSISHRHQVREENPGMEAMKVDQEREAPFLQVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBF0</accession>
    <name>A0A0N0PBF0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionyl-tRNA synthetase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460952">
        <property type="protein sequence ID" value="KPJ10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBF0"/>
    <dbReference type="FunCoup" id="A0A0N0PBF0">
        <property type="interactions" value="1207"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PBF0"/>
    <dbReference type="InParanoid" id="A0A0N0PBF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="312" mass="35852" checksum="E35F02C8773452D8" modified="2015-12-09" version="1">MRLTIRLLSSVARKRPFYVTTPIFYVNAAPHLGHLYSALVADAVQRFEKLTNPDCNIIFSTGTDEHGTKIQQAAAKANLSLSTYCDKISQEYRDLFRDFNINHTDFIRTTEDRHKKAVAHFWKELVKRDYIYKAKYSGWYSVNDEAFIPETHLRDDIVDGEKLKVSIESGHSVEWTEETNYMFRLSAFKTHLQDWLKTDGVVTPSRFQKQLLDYLDNETYFPDISVSRPSSRVHWAIRLINIANAELADTLGNLAARCAAPALNISNTQHHISAETLATCRGEDTTGKLMDAVERLPEKVRKSRIRDESFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBV7</accession>
    <name>A0A0N0PBV7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460794">
        <property type="protein sequence ID" value="KPJ12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBV7"/>
    <dbReference type="InParanoid" id="A0A0N0PBV7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857201" evidence="2">
        <location>
            <begin position="18"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="552" mass="62960" checksum="154020333B9E603D" modified="2015-12-09" version="1">MNNLILTLSLIIHANSALIEPDHQGHNAPIVIENSAPILRGALVDQYTGQALIIKIKSPSEIIKDSLSLIAFDRMDSQIAQDLRLTFGNLETHYQKQFKEVLSIHQELIATPYPLEVSEGNGRLIDISKYSRSKRSVWWRMLNFLRSVRPAARIAGKLTRYGKFMKGAKYAGYAASAAVFTYEMADIFGALPDKKYEEVSRQLEEIHAARTTDLIVMKNITIFTTGLHESIRDTTSQLNRVVSESYDKYEMYVKSSQILNSYIQQINIDLILIRLGGIPSNIITIENQRVWLERKLPSLLLSDISTITPHLRTTLKAIDEEKNQIVLYVEIPTLGTDFQLLNFVRWEPELVIEETCYSSPRKELYFAFRRDVGDGVIEDPLLIDPESCLTSGFILCESDAILETIPQLSENRICTQRRLKNKRRNKRSSANLFDMAQHPTYDLSQIVQKTFNKEHKIEQAGDSITSISKIIDQLIEESRKNEVNSKILLEQASRDDKIIKAFLSIGALLLLIGAIWVARSICYSLLEKKKHRSTERTEQLIRHIASLEDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBZ5</accession>
    <name>A0A0N0PBZ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBZ5"/>
    <dbReference type="InParanoid" id="A0A0N0PBZ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="501" mass="56786" checksum="014D6EFED0A5DA7A" modified="2015-12-09" version="1">MEEDLNENELEERFYSMRYKGNEAANLTTNLKDDNFVVKRPQTNIRRYWHTNDDHALQKVNRAKQPNLSSNEPLFPENIKSKGEKCNVTPLPADLSIFQSPVPQNIKKSIEIIENDGPMNIVELQSSDEDEVIEVKLPPKPTITIESSDEDEIAEVSNTTEENEKNVHKVTPDKITRNRSDRDVSASPVPSIVSSVSDDFIRGDCIALNISSKHPNKQSFDFSLHGSDIIDQSSPPKRKKKKKNKDSATSTPITNTPTPSTPVAKEGEYFATPKSKAKNKRQKTKNYSVSEKSIPNADVYDSDSNQSGNGIEKTNISYTFIDRSFPHADVYESDSNQSEKTSPVKTNQKPTEENICTSSDDNVSSENHTETEQTLELLRDNNETVEQCQPTIDLTETTFDDTIIDENIVMANVTGFQVEPDNTEQMNTIQNDATKFGSTKVPAILYEDLDFDNLKGKEKFCKKRRYSLSTLRAEMEKFYNESWGGENFNHREIQKNMSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC65</accession>
    <name>A0A0N0PC65_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC65"/>
    <dbReference type="FunCoup" id="A0A0N0PC65">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC65"/>
    <dbReference type="InParanoid" id="A0A0N0PC65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="220" mass="25650" checksum="C769CA546FF4688F" modified="2015-12-09" version="1">MFVSLDIVTFINFKLMQGKFELQSCKLQVTPQFIDLRREENLGLKMSPPPKGKAPTKGAKQILAENTATVTFYRNMSLGATAFFNIITFIFFYDQMTTSVIFMNVLVTIIYVVCFQMMKFISRPKYTTENVLLDPGLDLNMEGGMGEHVKDIVILSSITHLLALISNYFWLLLLLIPLRGFWLVWVNFLGPWFFQEAPEDTEQDEKKRKKMERKMKRYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCE1</accession>
    <name>A0A0N0PCE1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460599">
        <property type="protein sequence ID" value="KPJ13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCE1"/>
    <dbReference type="InParanoid" id="A0A0N0PCE1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48363" checksum="F77C88BF0AD69D32" modified="2015-12-09" version="1">MRTICQRLRRASVKNGNPHYFRVPRVSLIPRQFVLSTAKDAAEVPNGYALGNVVFPEYERDEKECGLTIKQLAAGASCDPAVLLMPIADVLLHPEYKHFGVKSSVALLKLLTPLASMNEAEVSDGTKGCDRAALMFRCSIDKADENETGLLPDRHVCTTGCDLQSGAPILVHEHTGHWNLFAMAEGGAPCPDPLRSRSPGTPSRHILLNPYVPWITTAISGQAIGSFSKDDPFGGAPCPDPLRSRSPGTPSRHILMNPYVPWITTAISGQAIGSFSKDDPFGFGPVPRAAYPLPKRAPGWLGHWWLGGIRCYDRGDGGADIYRFYHELFDIYPDTITPTMFTIIVTAWCNNGTEIIDDEDEYEETLDPSLYSSESDLEQEYVYDLTETRGIWINVTEPPLGSIGGGKGKGKGKGKGKGNATDSETDEESLKPPKVTWNEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCW3</accession>
    <name>A0A0N0PCW3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCW3"/>
    <dbReference type="STRING" id="76193.A0A0N0PCW3"/>
    <dbReference type="InParanoid" id="A0A0N0PCW3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8296" checksum="1C369E4435F9D9B2" modified="2015-12-09" version="1">MFCCKELKVIYATVVILLEADLLVNTKAMESLRSSSIAQKGDDFKSLELCTTRNQQRLGSVFGNFTRHHKKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCY8</accession>
    <name>A0A0N0PCY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal peptide peptidase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_05891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCY8"/>
    <dbReference type="FunCoup" id="A0A0N0PCY8">
        <property type="interactions" value="1937"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PCY8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="393" mass="42689" checksum="7832D9CB657CE455" modified="2015-12-09" version="1">MAQVGANMEYQEYKWAYSIMDSSKVSACLISMLLIVYGSFRSLNMEREARERAEREREATLLGGKPAPSCSHNSNVQTLNTMQALCFPLGSSVALLIMFFFFDSMQTLVAICTAIIACAALAFLLTPLCQYVAGSAGGAGGGARACGRYSAPELAAALLAAAIVAVWVLTGHWLLMDAMGMGLCVTFIALIRLPSLKVSTLLLTGLLLYDVFWVFFSSYIFTTNVMVKVATRPAENPMNVVARRLQLGGAMRDAPKLSLPAKLVFPSMHHQGHFSMLGLGDIVMPGLLLCFVLRYDAYKKATLVCQMGQVPGPRSMGSRLTYFHCSLLGYFLGLLTATVSAEVFKAAQPALLYLVPFTLLPLLTMAYVKGDLRRMWSEPFIAPNGKSGADFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDN7</accession>
    <name>A0A0N0PDN7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein engrailed-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein might be involved in the compartmentalization of the silk gland.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460280">
        <property type="protein sequence ID" value="KPJ16309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDN7"/>
    <dbReference type="FunCoup" id="A0A0N0PDN7">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDN7"/>
    <dbReference type="KEGG" id="pmac:106709476"/>
    <dbReference type="InParanoid" id="A0A0N0PDN7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000189">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019737">
        <property type="entry name" value="Homeobox-engrailed_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00033">
        <property type="entry name" value="ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="271"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU510713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="366" mass="41010" checksum="601A9FE8712903E8" modified="2015-12-09" version="1">MAFEDRCSPNQATSPGPVSGRVPAPHAESPVGYRPPSQYTCTTIDARYDRGMPNITMIKVQPSSPPPSPDRHHEMEYQNYYRPETPDVKPVINPDDRFEPDKRRQQPTAPIAFSISNILHPEFGLSAIRKTNKIEGPKPAGPNHSMLYKPYDLSKQNEYQKYSFDYLKSKEPSDFNSLPPLGGLRQTVSQIGELVSKDKEVQKVAEQRRPDSASSLVSSASSGAPSTCSTDAPSQASGNSALWPAWVYCTRYSDRPSSGPRSRRMKKNMNPEEKRPRTAFSAAQLARLKHEFAENRYLTERRRQALATELGLAEAQIKIWFQNKRAKIKKASGQRNPLALQLMAQGLYNHSTATESDEDDEEISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PED7</accession>
    <name>A0A0N0PED7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PED7"/>
    <dbReference type="STRING" id="76193.A0A0N0PED7"/>
    <dbReference type="InParanoid" id="A0A0N0PED7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="137" mass="15304" checksum="339E080137CE6CFF" modified="2015-12-09" version="1">MHDSAVEREMTLWPHKHQLHPSQVYPLPPTLNPYDPPPYHCCIVFILVDHLIVNLNSPFAQALFNARYKSREVGRGAGDREPDAMATVEGRPAQYGVSLRQLRELMETRGAEGLAKINALGGPQELCKKLYTSPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PER3</accession>
    <name>A0A0N0PER3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil and C2 domain-containing protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459692">
        <property type="protein sequence ID" value="KPJ20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PER3"/>
    <dbReference type="InParanoid" id="A0A0N0PER3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="4">
        <location>
            <begin position="1345"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="3">
        <location>
            <begin position="1504"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1633" mass="188483" checksum="16CD296F03C4BE8D" modified="2015-12-09" version="1">MSKNIELKHYCVTTYNESDSEQYHEIDQDALVKETTFTISPSSKHINAYDFFTQHNVKTKEKSKGKKRKAKNNKSSSIMDIINSELTSATLPIRENVIEFVNHDKLQNVYHKTATLKMLKWHHSDVERGRKFTNPVKLSPTFPKVLENTSAKEFPVGVHYSDPVMFNVLMADYTADDGLIQSQKFLDFEILNMKFIHHYKFSLETLLIVKLIDCYNEYLSIENSLKELCRNIKISRETKNNLRQQLLKISDSNKDGVRFDATLLKYTRALFYYKDAYMEMLKKEKEIVHKILSLWSDVEMVREKTNRTEVNYYLEINKIPITKDDYERDWNNAFEMEYLDLLDKIEFEYANAYLEYKENKSKYNSNGVEKKNINKPKLVIDEVKIKADTETLVDRILEKNKIEITLKCKKHMKDLLKPVHVLGSNDYYFKIYVDDVFVCQSEMFTFKDFVHSLDISETFSVQILPKNKILIIILYENDIQVSSTDLSIEEIKKNITQADVKPYNFTYADYVIPPSNKYVGSGFSIKEIATENKVRLKSGNLFKGKLNTACEVNMKIGWNEKFNKNSHEAVLNSIQVEKEIKRYLNGVDKPNINNLIQIINYLYDRNIENDEKVINSLTKICRIRVKNDYAFAIDENSDESIRLRLLLLRNKGGFVNVEKKLVPLFSSQISTEQLSTLQRTNRLIDLHNFDDSEDIDTIDLQRYLGLKYIQGLNENLQRTVNEFLLQKTHRDVVKDFKDLSLRGILSNQSNLMSMSISSHVTRNQIFRECESTEQEIRATVLRAFNLPDRAVDLLTENDDEDIERIAGFKVRPLRPYVRLSYHGTSAQSAPGIGCYPSWNQTLKIRTKNKGGFVNVEKKLVPLFSSQISTEQLSTLQRTNRLIDLHNFDDSEDIDPIDLQRYLGLKYIQGLNENLQRTVNEFLLQKTHRDVVKDFKDLSLRGILSNQSNLMSMSISSHVTRNQILRECESTEQEIQATVLRAFNLPDRAADLLTENDDEDTERIAGFKVRPLRPYVRLSYHGTSAQSAPGIGCYPSWNQTLKIRTKFSPLSSIHVNVYDECKVSARSMQEVSGSEQHRCGRWLAKFSPLSSIHVNVYDECKVSARSVQEASGSEQHRCGRWLAKLVLPLTTVLNQGTLRGTFKLTTPPLLIGYENSSEPKEARSLIPQVKRMIKKEISFLTLQITTSLSHLGEVQTYTQPIPNVSNDDRTIKHLNDFLTGYLNEFPSRSISLTYVGSSGKNTCVTEFLQPIPIPDLEWFPKNPKRPGSALSKSSGHSKSSSKSSGKTNELSSPLKEEKVNAYSGFDESWRSEDSQLSKALNFCIRYVALIPTYEVPGTPVVTLTGSELLQVLNGSPTDHTILLASYFLHLGIKCWVVTGLALPRGLSTYLLVKYDLITRKYTTGEDQVYKSRGFFKKSDDFVWHVYDAVSGEQFELRDVACPLKTVFFVFDEYNIWVNIQSSQDCQTVSFDFSKSSDWQQVFDTPRQFVSQPVRCVREMYRAPSDVCRLQDLLEAKLMTKVQKWRPRTKTVWNRYCCTLLRETLPQWEFWSFDTTDRRPEPGHRLKQLMATYKIFGFPLNMHYINTKSVLANVKATSVHVNDDPNVEFALAVQMYAYPNNVISLWVYLASITRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF67</accession>
    <name>A0A0N0PF67_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_00633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01005656">
        <property type="protein sequence ID" value="KPJ20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF67"/>
    <dbReference type="STRING" id="76193.A0A0N0PF67"/>
    <dbReference type="InParanoid" id="A0A0N0PF67"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="47" mass="5497" checksum="D14F4BBCC9E2F327" modified="2015-12-09" version="1">MEGLSAFLHTLRLHWIEFQSKFYAGEGYLFQPFSFEVLLDSSAQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I517</accession>
    <name>A0A0N1I517_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ461161">
        <property type="protein sequence ID" value="KPJ08023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I517"/>
    <dbReference type="FunCoup" id="A0A0N1I517">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I517"/>
    <dbReference type="InParanoid" id="A0A0N1I517"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000131">
        <property type="entry name" value="cyclin-dependent kinase 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="41181" checksum="3632589FC6A83C13" modified="2015-12-09" version="1">MRPKRPPRPKSEAFLGPHEHNRRTKRFSAFGGDSPFGKSEAYMKLEQLGEGSYATVYKGYSNLTQQVVALKEIRLQEDEGAPFTAIREASLLKELKHANIVTLHDIVHTRETLTFVFEFVDTDLSQYMERHPGGLNHHNVKLFMFQLLRGLSYCHRRRILHRDVKPQNLLISSHGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMLCGVPTFPGVRDTHDQLEKIFKVVGTPTEESWPGVSRLPGLREHVSRWGTCPARALGAAWPRLREAGRDAERLAAALLQPEPQRRLPAHRATHHSYFAALPPRLRDLPDEVSIFTVEGVCLHPETRHVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6Y6</accession>
    <name>A0A0N1I6Y6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6Y6"/>
    <dbReference type="KEGG" id="pmac:106712958"/>
    <dbReference type="InParanoid" id="A0A0N1I6Y6"/>
    <dbReference type="OMA" id="TENCRAM"/>
    <dbReference type="OrthoDB" id="7319517at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23009" checksum="CEC3AA2D31E7E121" modified="2015-12-09" version="1">MTKSCTEDVTKSSDRRPRSGSEVSPRVPLHFTVHKPGCHFESCCGVCNLFPGVLLIAFCQVLVGSVLLTLILTHGKQYDKIHNTPDSQIMSLGTGAMLSGVTGAGFLLIIVALTENCRAMLIYLLVAMFVLMGIVSLAVAKIGRSCIRFKDASKIKDEQHRLVNLACVSGLFTFFGAVLYFFSFVVVFSFYHFRYVRRAILMHEAECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I874</accession>
    <name>A0A0N1I874_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the hemolin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460426">
        <property type="protein sequence ID" value="KPJ14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I874"/>
    <dbReference type="InParanoid" id="A0A0N1I874"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="394"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="484"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="643"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="731"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="823"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="917"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1453" mass="162344" checksum="0A054BD0A37F4567" modified="2015-12-09" version="1">MALCLRHERPPTLPVLRCLLPVNHQKSSFAFVIDDTGSMQDDIDQVKSKTELIFDKIVASGTSSIGNVVLVTFNDPGVRPALITTDVNTFKTTLYSIVADGGADCPEMAMTGIEVALSNTLPRSYIYVFTDASAKDYEKFPKIKRMAQKQGSQIVFLLTGVCNPFYESDPGYKVYHDLASATSGQVFHVDKGEIGQVLDFVGKTLDQRRAVLATAVLPPGYDKTLSFPADKEIDDIHIAVSGLKPKAEVLKPDGSDAKTTDIFKNSKTLVVGVEKLGSGNFTAKVGSETSTSVVITGATAINFQHGFTGFKPTSIKTTVTRPIAGKPSFLAIELSSKAKDVKLNEVELLDLDDNVISVRPLKEVGKDFYVAEKELPPTSIFRIAVEEIAEKRAPTVTLIGDPTREVPYGEPLQVQCKINAYPAPKVQWVDEKTGLTISEMAVEEELPYDYISILDLEQVKINTSYQCRASNEVGQDDITVTVRPIDRFVALNVSKDTSIDYDDEGKLYCIIDANPPAQITWYLNGDLLDNDENLEKSEDGSVLNIIYMKPKFEGKYNCEARNELKREIYYINLVMTGTGIPQPGIRWSFKHRYAQEFVVLDSYSDILEISSTDINAAGTYKCEAFNLFGKAEHEIELVVKYPPKITSKRHTIKSKSGEYVYLTCQVDGMPRPNVKWTFNGIEIKKSLRQRIYRDNMLGMKVSIKDSGTYNCTAVNELGSDTKIVNLTIYDPVRITPPIKSTLETKVGSTIILPCEAFGHPTPSIKWVFIKEHDHSELRRPSDPSGSLQLSRVQLEQSGQYLCIAENIGGSSNITYTLQVLAPPHIVKSSVSKSITAVVNDLILTLPCEAKGNPKPTIIWTKDELRIPSGTYWHDIKEDGTLVIKNVDDITQGRYVCIAENSLGTDTDYFDVLVQNYPDASEKRGVLDVQLGRSTKIYCDIPHTSTDRLTWYKDSILIATGELYLNDINMGDSGLYTCRVNTFSGATSASKMVNVGFPPYFNEAASEVIYYVADAEAYLSCLATGVPTPTVTWLHNDIPIEFTEMAYRFYMSSNDLGRFSCTVSNSYGTISRDFNIISQCSFKAEMNPDSPKVSVLDARDTTKPDDVIVNIQVGEEIIIYCIKGFEIFPGTELKATCVQDTMLKIGDKEIKYNDIKCRKDVTPITKPTGKRCSPTKRDTETIKVGIETDGKFDEVFEICYDKFNSIPIYSTHKINRYLAGVEPTDVNWYDNDLVMYNYDELYDCTNQMYHINAIRPLARGLECCFTKRKLVNPQDVSPGVSQIATYSNLNIVPHWSTCGTKNWDDIEMRIRILAKPLNRNLIVRTGTSGQLRLPTTSLRMQNIFIHDRSNKRQPVPKFLWKVVQDEFSRSSLAIIQVNVPDLKLSEALSYVVCKDICNLVEWMKSPVWRDVKYGFTYCCTIKEFETAFGLEGQFSIGLEGIFSDTLIIPDTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8F1</accession>
    <name>A0A0N1I8F1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ester hydrolase C11orf54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_02211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460784">
        <property type="protein sequence ID" value="KPJ12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8F1"/>
    <dbReference type="FunCoup" id="A0A0N1I8F1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8F1"/>
    <dbReference type="InParanoid" id="A0A0N1I8F1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="102"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="398" mass="43604" checksum="E5E28A1C53810C79" modified="2015-12-09" version="1">MRAQEAVYTASYKVMPHSAAGRRLRARFTTAGPALTRHILVEAAVIDTNNLSNMATVDYAKVPIQTKALYVPPLEEMADAEFCQLIENVQDKRELIAMCVAVLSHELRSTFETVEVSVVDCPDLTQPPFDLQAPGISGNATLVEIGGPPYLMPLVQRDKVYDLAALLRHLRRDPALLTGAGAGPWPYIGVNCEGIINLRMQDGAVRQGTRVVSVQPVGAAKGSSGYLQRRLPDAETRTALLGNYLLSDGAPGKVLRVVAKRRVGADNFITAIRRALQARYGERGVGLGGAFVLREGRVKHHVMPDFSSTALCSDEDIDRWLHYFEMRAPIVHVGTLVTADLGLDLRVQHFHGFSAHGDGGHYHYDTTPDSVHYEGYFTPADTIVRVDAPRDTHAFGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IAA4</accession>
    <name>A0A0N1IAA4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 555</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IAA4"/>
    <dbReference type="FunCoup" id="A0A0N1IAA4">
        <property type="interactions" value="1746"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IAA4"/>
    <dbReference type="InParanoid" id="A0A0N1IAA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="469" mass="54957" checksum="6006011E54E5600E" modified="2015-12-09" version="1">MEDLCSTCLCVGRNLFFIGETGFYNIFHQILNEIQVYDTSLCVRVCWECRAALHRFQMFKSQVQRSYTQLLHVQVQNGSSKLFLAKEPKLKIQQVVNINYPEIIVKEESDDDIPIDKLKSEATDEMHCEPETFVRDLNVTHTKESNKKKNKTRLKKKIKKKKDKIKVDEISDSENWPDLNTEDTLREEENLLEDEIVNVCDTEIQREVNLEELDVKDIPGEVGDVGEVGGEVRAPRRAPRSRERLPERPQCVECGKMFSSKKTYRYHLNVLHKGQNRYPCPRCGKVYQWKSNLGRHMRSHKARDSGELHCSPCDKLFASVATYRQHLRVSRRHVPETDFSFTCDECGKKFVSKTRLRDHIDWEHLHNIKFRCHLCNKNVHRDKDARHNLCHVCGKSYQNAAKLKYHIVAMHTSETPYRCERCGAAFGWYSSLYRHVREVHYKMKVQPKKTKKGKKNDITPHILPQTMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDG5</accession>
    <name>A0A0N1IDG5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_02496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDG5"/>
    <dbReference type="FunCoup" id="A0A0N1IDG5">
        <property type="interactions" value="2017"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDG5"/>
    <dbReference type="KEGG" id="pmac:106718273"/>
    <dbReference type="InParanoid" id="A0A0N1IDG5"/>
    <dbReference type="OMA" id="ASNMAHH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11531">
        <property type="entry name" value="CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 14 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="15">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="16">
        <location>
            <begin position="262"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ08088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="531" mass="59614" checksum="49F8BDDC6A66C237" modified="2015-12-09" version="1">MANTFRGVTVSAVNNDGALTPRFNFPTNVNVDYDPQGLSVKVIRADPVLAQELLEFPVHNLSECSRVAGQSYIFTIDNETLFFKFASDADCQNFHLLVTKIKAGRSSSVFTVRTEDSSAMQYFQFYGYLSQQQNMMQDYVRTSTYQRAILSNLNDFKNKVVLDVGAGSGILSFFAAQAGARKVYAVEASNMAHHAQALVRANGLHDRITVVAGKIEEIELPECVDVIISEPMGYMLYNERMLETYLHAKKWLKPNGNMYPTRGDLHIAPFTDDALFMEQYNKANFWYQTCFHGVDLSALRTAAMKEYFRQPIVDTFDVRICMSRSVRHVVDFLNANETDLHRIEVPFRFQLTQSGTCHGLAFWFDVLFAGNTQHIWLSTAPTEPLTHWYQVRCLLETPIFAKQGQALSGRVLLLANKRQSYDVTMEINLEGTNISSSNTLDLKNPYFRYTGAPAAPPPGVNTTSPGEAYWNTIDATGGLTNGQVILTDGTQQYCTTPDKTIAYGAHPNMIKTVMLQEEFIKRIGISQNGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDQ4</accession>
    <name>A0A0N1IDQ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDQ4"/>
    <dbReference type="FunCoup" id="A0A0N1IDQ4">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDQ4"/>
    <dbReference type="KEGG" id="pmac:106716428"/>
    <dbReference type="InParanoid" id="A0A0N1IDQ4"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="16997" checksum="52933F3AF7DA5852" modified="2015-12-09" version="1">MAVCVAVIGKDNSPLYIGGVGNDTNTDNELSRQWLVHTALDALEERLATTNTNTANSASNASRTDLRDLYLGLLYSTDTHKIYGYVTNTRIKLVLVTSSTSPSGSNIRDAEVRTALRRLHSLYADAICNPFHLPGEQITSSKFDKQVKNLLLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDZ9</accession>
    <name>A0A0N1IDZ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_03549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the riboflavin transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDZ9"/>
    <dbReference type="FunCoup" id="A0A0N1IDZ9">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDZ9"/>
    <dbReference type="InParanoid" id="A0A0N1IDZ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF10">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="37692" checksum="B194AF13A6A36C7D" modified="2015-12-09" version="1">MVKLKRRITLDLAVAAFGLGSWLGVNGTFLQAPLLLRQLPEGWALPTWITLAVQLGNVGIVVHVLARRLLPRIPDAAYIYCLLATGAAGLFLNAFLHAETVFWVGAERSLSFLTLAFCSALVGCTSSVLFYPYLRHFREEYLVTYMVGEGLSGLLPSVLALIQGVGGEPECVPSPDGSTWTTVHPPPLFDTDVFLSTLGGLAIVSLLSFTYIHNTSQFDSERKSPTENKELRKEAPVRLLDQSWACLFAASAALNCVNNGVLNAVQSYSCMPYGATTYHLAATLKVAADPAVCLAAVWLAPLSVRALTAMLAAAAGPLAYMLATALLSPTPPLQDQAAGRALVVRTAAAYNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEC0</accession>
    <name>A0A0N1IEC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01032616">
        <property type="protein sequence ID" value="KPJ21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEC0"/>
    <dbReference type="InParanoid" id="A0A0N1IEC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13079" checksum="BECE9D6374F11368" modified="2015-12-09" version="1">MQTRRQPRTAARRSHVRASVRAQLVNLKITSNDVRIFSSPSEAQNLSSLRQRAGITSLSLFGNDYELDHFTDDEQDNSSGLMTAVMRPTSNMLSAYRQVIIILYILIKFVCLYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEE4</accession>
    <name>A0A0N1IEE4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460940">
        <property type="protein sequence ID" value="KPJ10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEE4"/>
    <dbReference type="STRING" id="76193.A0A0N1IEE4"/>
    <dbReference type="KEGG" id="pmac:106715607"/>
    <dbReference type="InParanoid" id="A0A0N1IEE4"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="472" mass="55708" checksum="83F9A27403CEE994" modified="2015-12-09" version="1">MEEEGVTYCLLCAQIKCFSKLINLHTNGMLHKTAIKLSRLNISYDDLDGEKLPRMICISCMEKLDKAFEFVSEVDNALAILKELYVNKIKTEDNSIENQVIDELDSISEYSVHIKPEDTQSTDSEASCDSLGKKRDTSSERSLSDVVEKKSDNSSKQLTWNDYIWTCAYCETQFSTLEELQTHSMQYHQCCNAYKCYDCKIWRMNLKEFIIHVKSHKKYLKVMCHKCNKKFMFERHVHIHLKTAHVTKSPFLCLGCDIDFQNQEELSKHRQAFYKNKQRKNNIPLRIKSNTNDLFCITCKKSYKSKVSLRAHLLTHTDRKREHICEKCGKGFFRKRDLAEHTIVHEDERRHQCKLCPMKFKSLYTLKQHVAIHSEEKPFKCDECGREFRLKNHLASHSNIHNDTRPHECTYCDKKFRLRGTLYVHLRQHTGEKPYSCDICVRKFTNWPNYNVHMKRMHKMNMAKKKLSVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEH7</accession>
    <name>A0A0N1IEH7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein unc-79-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEH7"/>
    <dbReference type="STRING" id="76193.A0A0N1IEH7"/>
    <dbReference type="InParanoid" id="A0A0N1IEH7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="779" mass="83990" checksum="43A09FCAE44437A8" modified="2015-12-09" version="1">MSGQSVEVWPDQYSQTSPRANVLGKQKRVVDIFPAGSSTSPDTAPSSNGDALGHAPHHHHLRSPGLAYASPESPLSKMEVAWHAPPHPRPHHPHHTQQPFHIPPQERLLPIGPKPNKEQYPVFNALVDRVREALSLPHDDSTDRTDSSRSENEPTPTPTPTGRPQDLTKKLSSDSTSRSPRRLARQVAQLGSPPHAPAPQHQAQTQHTPRSSARPHPTESRPAGAWWGEESRAGRRAAHAAPRTAPPAAPPSRSPAPRPDAALRHRCAECGSVVEQYSDEELGLCVIALGTFIHREPASAAPMLPALLYCISSVAQQGNYSWQTDSNVRLPGSAMLVAQQFLRCVLHQLAPNNVFLQIFLQRTPEKQRITFFKSIAQAFVDFNELYPCGPLQLLLEHLNSKKSLPIDQMPTIAGNIAMYLECLAPEALGPAAACGALLAALDQLLRGVALQLAQLDDALPLLRASAAALRVPQAHQHKVFPIGHFPSLALCRGDRRPPPQSILEPISKILSYAVQNFVVRLPLACEVAAACVRAFGRDRDKLLLCRVLVFELVQALRTKTTVPDDNLFMLIQFVLQGRGCTLLLPPALGGVWTAGAGDARELAAGAVDCMRPHLPDLLDLLHDPHLLNKIKGSVSKSIVNRNLICLNEDTLGAIVKGGIAQYVAAELAAEQGRARQERGQPAARHHLPWLTAALPGSREVGECVGRVRQLSWLVMGALCNSRSGQPLQQPVPQDATCHITDHIQTIMSSYVEQVRGGGGGGGGSGAGSGAGAGSHVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEJ8</accession>
    <name>A0A0N1IEJ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460928">
        <property type="protein sequence ID" value="KPJ10815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEJ8"/>
    <dbReference type="InParanoid" id="A0A0N1IEJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="159" mass="17876" checksum="D6D706761F881433" modified="2015-12-09" version="1">MEAKQKFPKKEELIHHIQHEIEKLLREATERKVRSTLAFLQKTNTKISNSSSIQAGTSTESVPNVECGDHVQINDHNIQHAESAVQDEIDDQQSGDQDLDGGPQPAGASKRKNQRLVISDDEDEAMSNTTPTNWQNHMDMLVPIVSLETVHDSPWTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFC2</accession>
    <name>A0A0N1IFC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFC2"/>
    <dbReference type="KEGG" id="pmac:106710131"/>
    <dbReference type="InParanoid" id="A0A0N1IFC2"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF6">
        <property type="entry name" value="EG:133E12.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1772"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1399"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1865"/>
            <end position="1881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2116" mass="235478" checksum="2F64E4476D00A3E1" modified="2015-12-09" version="1">MKTKQIKEESDKSVDEDTIEPKTRARKKASDIADEDKNKPNQDEKPPKEPKKTVGKPKAVVKKRPLGIRKTLRNKKIVSAKEKLRNVVKVPGKRGRKPAVKPIPETCQETVPLIPASEIKKEPIEDTTPNSRSSSPKTGRRQRLSSDMFMMKSVLGDSPTSLVLGPRTSPYSMRSERSNSPSMFEGKHLRSRKPRGAKSKLLSEVVMKEQKKRRTEGVEGSDDSKKLKRGRSCSRDGSEFSKCSDVTESDVSLSETLIDTENKELNKNIDKPKTDLDVDIENNVQISTISKVPSLNIDSKLSDATGDVEPSSNVQEKDKKKLSLKRTTSVDSDNNNSNRLKLENLNASELEAKLLPKTEQNTLFEERSSILTSMSRTFNSKEVSKNIRKARRGKKVAGVGRSSCGPASKNGINSTITNDAADDKHETLDTLSKEINDLINDLDQNIDQDQEIASKVTDQMPSKPVAKFYGLSKPLGDSNSIIAPETPNKDKDLISPLTNEMTPSKSDDSDNIRLRYEEDSVEKSADARRLEIPYNCPTVASIDKLMDRLKEFEELDKKRQRQESESKVTDNKSVMVTNDVVLIPKSGADIKPLKDIQTVRSPEKIIEKENVLSCFENNSAISIVKRDQVRKSIDVDLPNSVTLIKRNSFSARKESTSSNHSKESDAISVFEKSFGKDVTLTELRKSVDKGSSSAQIDLHQFALHPTNTNQALVGLVLDSSQISITPRVVEPKVTGDQKRKSRDSLSRKSSESGIENEEKVTSIEKMKSPTNQMKSQAITIIPAPVAVKSPEAAQAMETEVLAPPLDNVKPVPASLSLASEVVNTAVVADPENKLANLDADINNHNETEKTEAATVPENETVVPDIPAKAEPPVEVKEEAKPTVEPVKPKETPIKSKESITKVVDAKPNSDSRKSTENITEAVKLKSPRVKSARNSIESQAGPSNMILETPESQKRKENVLRTLGLLTHKAANEAKIEKAKEKERIYGSNYCSLMGSKNKSKSGDYTGTLKTVIKLPRNTGERERKRQKTSLKMTFQKTKPRSGKVAVEVGEAAGEDHYTVERREGGAGATSDGGHRKSHYSNRLNNHDTETVPEPEPAKDTPNLVIPEKASSFSIHPDRLCLDQCFYCGGKFGLFDTPCHIAQMKSTERQRKVLDNEEKLTIDSCLCDACYRHVDRRANCPSYRKRPLVKPLTPQLPTLPENVNENPLSPTEDDSSEETKLLREVRTATCHTAGCGAGAEHSVRRKWLIKMRSSVNKLLKLECDYPGLHTIPLCAEHYRTLAPLMACVLCRRRITKHHNVHFIHHGYLELNPYLKEAGVPVQFTERPVLCKMCRNYCALLTRPGHNDKYAQACRRRLLQIYNIELPPELEHEVENTLILEDSGLGKQKKKARTKSKQRKSSEPDKPDSESSERATESSPEKEKEKEVEEPKSTPPIEEDIESLISSNKIPVPGATKQPEEPPSDGSESEAVFDCDAPIIPLDKRTELQYLLQKQNNPKQFIQKPPNLTQKQKNILKVHNPGVQKPGYQNKINDKNSKRLHKLGQIFAHKEKPTGDVEMLEAEKPKEITILKNISLNDECTIETIPNKKPADINTLKNKWQMSESFTQVKKNLSELSKKLSVDKEPKKTSDMKYSNPVKRLETNPSISVRELFPGEEEMNLQCNIEFNNVKGVTPEGWEKCNTMIQYDVETKKLWNELQRPYGNQSSFLRHLILLEKYFRNGDLVLSHNASPNATNYSDSVQSRLRSYDNVTEPPKRAEPAISLLEFRKKPSVNGKSLLKSNHGAEDKDPKKFMPPPVVPKPKSKSEKPKLKPLPPELIAINTPNAQGRKAIQNVLHNIQQLVKGVSAADPTEVAAAPLPPTPKFEPPKEKKESLPKPDTPKKTKTTSKPWRPTLMPITQENLARIAREPTQVAVDGRTLPSLVQVMSSGKRYHITLQDYNKMCIMRREKLQQLQDGDCKPKKEDTTIVTEVQTSSMLGNGGTVLQNIPAEEEKKESDLQISANAANILKNVGLKNITIAPIPPKTATVTSQTLSPVVTSPSLLMTSTPIKIPQLGPAVSITSETVLTPTLPIMTTNMVLPKIPKSLTVIPQTVAQPLAIPVATLAPTVAVSTDQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFK8</accession>
    <name>A0A0N1IFK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFK8"/>
    <dbReference type="InParanoid" id="A0A0N1IFK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="26578" checksum="A4992086BF183EA3" modified="2015-12-09" version="1">MDMILSSKFATSWWAAHKCQISENEIEDVDIPNLCDDVQKCLAGGAGRGGSSVLPLGCLTGADVGRGAFGVLTLGPAAALLHGAALLLLHKAKHTLQDTFELTQKIMLKNYQIDSDSEDSEEDEDSELERSSATSEMSKRVRTSEVSEGESDSNNDVSDVSFSEELGNDSDENEDIDSQSSSQDEDDVCIEVEDRAVQTCECVREEGAGGCGFDPSLKLGVMLLYDDHSQPIPSKIIISSINPRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG25</accession>
    <name>A0A0N1IG25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chymotrypsin-like elastase family member 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_02755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460047">
        <property type="protein sequence ID" value="KPJ17984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG25"/>
    <dbReference type="STRING" id="76193.A0A0N1IG25"/>
    <dbReference type="InParanoid" id="A0A0N1IG25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF143">
        <property type="entry name" value="SERINE PROTEASE GD-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873932" evidence="9">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="176"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="436" mass="48439" checksum="4FFCD7337508CC63" modified="2015-12-09" version="1">MKTVLFYFSTLLISVHTQDGWAFVGNPLLHAYPCNNETDITVSFEPGRPPGEENQYNVFISKSLPRYTKIKLKFDTEAVVTLYDSAKARISVQNDNEFTINFFDNAESVGFIVKGPVTGTVPYFESLNINTVEYCKSPNKGYLDNLILGTKLSAESHLKVPDGSCGRRKVEHTELIVNGADTKPGDWPWHAALYRVKRNIIKYICGGTLLSKTFVLTAAHCTTVRGQPVVPETLNVVLGKYNIAGGDLEAQEKTVQEIIVHDNFVAKQLDNDIALLKLNSEVLFGDYVQPACLWFPTAVDKLPNREKIVGTVIGWGFDQNNALSSQLRQATMPQISESDCIKKNPLFYSKLLNNKKFCAGLNNGTSACNGDSGGGFHVFVPDETGNDFANATGAWYVYGIVSLSVSRRDIPVCDPNQYVVFTKIVEYRGWIQKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHS1</accession>
    <name>A0A0N1IHS1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHS1"/>
    <dbReference type="STRING" id="76193.A0A0N1IHS1"/>
    <dbReference type="InParanoid" id="A0A0N1IHS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="848" mass="98263" checksum="4F69F33BFB44204C" modified="2015-12-09" version="1">MAHATVPKYRELKQANRAKNPVSYEQVSALCKPSDVFTNLSNEFPYYLPKIIKTSLTKKKYEDNIEIKERIKNLSEYHTLAREPIQGKLTFLAFDALAESKDLTEEKLHQVQVLAWAVELIQSYFLIGDDMEDNSETRCGKPTWHLLPDVGLLAINDASMLRSFIYEMLKNNFDQNTSTKVENYVNEAFLTINIGQYMDIMMSKSKDFNKFTVEQYNFLNDHKSSFYTVKLPILLALELCNKVSQDSYENVNKICTDLGILLQMQNDVMDYIDRDSASVKTSSDIQKKKCSWPAVAALQHLNEEQRREFMNCYGRWESEKVERVRELYKEINLPHLYRLEEQKINKAVLQKIKKLPDNATPSADFFYKIFDFVRQYTEDISPSKLKSNWWERRVVPVYPAPLRPLGDSTAGPELRSVDGSWEGRTYRFTGLHSPVVTGSGGPVRGGSRDFLKDVGGIRPHLVEEPLRRLAQARPRRSAKAYRRSKTQNQVLQKEKLLSRKFFDDFPKFLPVLLDDSLSKTKIIENESVRNRIKRIAEYNTLEKKPVEAELMLIAYEMLEKNRNVSAEFQHQAYVIGSALEMIQSYFIILDDMQDGGKIRCNKPCWHLLPDVGMTAVNDASLFRSFITDVVRQNVHEPLFSHVMHIFDTIYYTLEIGQLIDAQFVKARNYDDFTIENFDAMNKYKSSFYSVKSPILLALALCKKLNSESFAIVDDLGTDLGILIQSHNDLIDYLDVDESVASKSGHDIQNGKCSWPAVAALELCNPEQRKIFNKCYGSWDPKDVQQIRKIYDELSLAEVYRKEEQTRYDNFLNKVHNLPKDSTPSVEFFLEIFKNFRGYTENLKKYMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IIK2</accession>
    <name>A0A0N1IIK2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_05544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IIK2"/>
    <dbReference type="FunCoup" id="A0A0N1IIK2">
        <property type="interactions" value="1106"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IIK2"/>
    <dbReference type="InParanoid" id="A0A0N1IIK2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="108" mass="12294" checksum="DD19484AEBEA88C4" modified="2015-12-09" version="1">MGLAVAPNPHHTLGALYGKILRTLNKMPESAAYRKYTEQIVRERAAVLQQTKDTYELESKINCGQAEELIIQAENELNLARKMLTWKPWEPLVAKPPKGQWDWPPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJD2</accession>
    <name>A0A0N1IJD2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="LADJ01009487">
        <property type="protein sequence ID" value="KPJ20933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJD2"/>
    <dbReference type="InParanoid" id="A0A0N1IJD2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="215" mass="24364" checksum="0E02FE92369881DB" modified="2015-12-09" version="1" fragment="single">LINRLTYNDELINWCDVVVPCGGDGTFLLAASRVRDANKPVIGFNSFPHKSVGRLCLPTWCSNDVKGALHALKEGRFRWMRRSRIRTTITCEAKVLDTITPVDLHTLHYCRWPFARLPICNLKVFIGESVTSRVSLLRLQIDNGQWTHTKSSGLCVTTGTGSTSWHFSINCLRTHSVLELMKILGEEFDVKLETSVERAREVAERYNQKLMFAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INM3</accession>
    <name>A0A0N1INM3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INM3"/>
    <dbReference type="KEGG" id="pmac:106716039"/>
    <dbReference type="InParanoid" id="A0A0N1INM3"/>
    <dbReference type="OrthoDB" id="7414394at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012497859" description="SHSP domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="28927" checksum="3CA53778FF0C7232" modified="2015-12-09" version="1">MFAIILTALLACASAAPHYRHSHHHGYGPPSPFGSRDEYDLGGFGMEPHFGNDNDFFRDNMFDTRRFWAELSREMSMLDQLLNDFAKRFPSGVSNEGIDKTTNEYKVTVALNGFEEQDIKVKAREGLLMIQAIRNKDEAGQNSYLSVRTLPDFVNVTGSWTYEDGVLKIVFPLISTPADGETTTEITTEIPEQFKPESREETTVGEDIKDADVGLDRGDVAKETELLTNEIPRKEAVEATTYAVDLKDEVEFVPVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP35</accession>
    <name>A0A0N1IP35_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein turtle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460642">
        <property type="protein sequence ID" value="KPJ13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP35"/>
    <dbReference type="STRING" id="76193.A0A0N1IP35"/>
    <dbReference type="InParanoid" id="A0A0N1IP35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874193" evidence="4">
        <location>
            <begin position="19"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="273"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="368"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="661" mass="71302" checksum="723E5979F2EBCA1E" modified="2015-12-09" version="1">MALAWRTVTCAALLVAAAASLLPLETERLRATVGGYAVMNCHLDFPFGNEIPYHLQWDKDINSEENAHCIRSSYYSVRAQRSKCARVQCGAVQCSEDAVNSVTLQGETILSWLSGEGAVRVADRWGGRVRRVGDGGGPAGLGRGSINVSAVRETDAGLYRCRVLFPNRSPPARNNGTFYYLEVDGGNLIVTPPMNTTVVEGERAELECVPRAAGADVQWRRAGGGDAPTAAPNGSLVLLRAAAADLGEYECLVRAPDGQLQTASAFLDVHYKAKVVYSPKERYLAAGKAASLDCHFSANPPLTNLRWEKDGFLFDPYNVPGVFYSMNGSLLFNRVDESHEGVYSCTPYNALGTEGASGGVRVRVLRAPRLSARPQPLYVARLGDTLTLPCAVVEPPHHAAPAPALRWTRKDGSSLPEGRHSLRDGNLTISELAEEDRGVYVCTASNEAADVVAETELLIENVPPRAPYNLTARPTSRTIHLSWVPGELDSRTIHLSWVSDSEISEDLGTASAAAITESDVTASGEVGDVGDDGEEMEVTVRLIEEGALVRWSRAPHDHTRCSVRWYRGEARDPLAAAHTHHDYLLVSEVEEGAEYLARVWCASGARGGAALRVPQYARMRGVAAGAAAAALLLAAAAGALWAARHRLCRAPRTPRTHRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP53</accession>
    <name>A0A0N1IP53_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460746">
        <property type="protein sequence ID" value="KPJ12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP53"/>
    <dbReference type="InParanoid" id="A0A0N1IP53"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33510" checksum="81EF465906531402" modified="2015-12-09" version="1">MKKHSAYTEWADAYSCTRHRCQPGGRNLAIYTVGCKRVEPPESAIECEEVVEDTNMQFPYCCSRLRCLVVVRGEVWTRVLGQPWETLPAAPWSHMYKMKKPPPPDASFLPKHGEGPVYELATDNDEQGVLRATKKATTEDPANCKDSVHRSNSNAAPDIVIALETNKEEKEIKKIESGRQDVVEEAPEMRNEMDYEDLETTTEKKSMARQITWTEIPPNQWNEHEISMDIENAKEQEIEKKESKSPNLQALVDAIGSRMRDIENVVQRMSQKVHRNKPQLTVMGNSINSIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP60</accession>
    <name>A0A0N1IP60_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460572">
        <property type="protein sequence ID" value="KPJ13953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP60"/>
    <dbReference type="STRING" id="76193.A0A0N1IP60"/>
    <dbReference type="InParanoid" id="A0A0N1IP60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="146" mass="16306" checksum="0A6084AF81EDC2A8" modified="2015-12-09" version="1">MCEFFIRLNSADPTTTESNTVTSFYVLSTGVVPAPVMLKLGNSTIDSTKSFKVPQPTSDVTDSGRTITNKPNLILDMVPHVVSAKNTYFDHDRKYGPNFEDSPKGNLTKITVQLGEDAYLNCRISLLQDKTVRIYNCVFKIYMQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPM1</accession>
    <name>A0A0N1IPM1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460417">
        <property type="protein sequence ID" value="KPJ14869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPM1"/>
    <dbReference type="STRING" id="76193.A0A0N1IPM1"/>
    <dbReference type="KEGG" id="pmac:106711011"/>
    <dbReference type="InParanoid" id="A0A0N1IPM1"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF166">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="834"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121648" checksum="BC96ACD0617712CE" modified="2015-12-09" version="1">MKIIGGIENITKREEDYLIKYKTGETAKVYVINSHVFRYYMSPNGEFFDYPIPNNPDDNAKITIKNIADYDEDSFKKSSVKDVDKYYEIELNKVQIQFDKINGIMSVYDKRTNKVAIEESSPLSYDDDITVQKLYQKKDEYYFGGGMQNGRFTHKGNIIHIVNTNNWVDGGVTSPCPFYWSSYGYGVLRHTWQPGVYDFGSESLDFVTTTHKTDHFDAFYFINSEPRDILGDYYELTGQPIFMPEYAFYEAHLNAFNRDYWVKATPETPGAILFEDGNYYKSYKPNEMGDKKGILESLNGEKDNYQFSARAMIDRYRRHDMPLGWFIPNDGYGSGYGQTDSLDGDIENLKEFADYAREKGVQVALWTESNLHPADPSHPKKGERDLGKELSVAKVVALKCDVAWIGYGYSFGLNAVDDVTKIFISKTNVRPMIIMVDGWAGTQRYSGIWSGDQTGGQWEYIRFHIPTYIGSGLSGQPLIGSDMDGIYGGKEREVNIRDYQWKTFTPLQLNMDGWGRIPKTPFSFDDEAISINRAYLKLKSMFLPYNYTIGHESIRGLPMIRAMFLEFPNESLAYTKDCQYQFMWGPNILVAPIYEEGFNRDGVYLPDKNQVWIDFFTGEKIQGGKIINNLDVPLWKIPVFIKDGAIIPMTKPNNNPNEIDRSTRIFTVYPNNDSKFNVYEDDGISSDYLKGQFATTEIIVNGPASNEQGDLLMTIEKTKGNYKSMMKERTTLLQIMASQDVEHVKAAINGQPLLITKAPSFDEFEKSVNAFFFKNDFEINPYLAQFNNIPQAVLLIKIGDLDITSHHIQIKVKDYANIAKVLGKNLNVNNDLATPNNFEVAGEVTSTNITLQWSEIDKVYYEIEKDGIIYSSIKRTKFTFQDLKYKTEYLFRIRVVNEYGVSEWSDSLKVKTLDDPYKNVIKGVKVKCNIPCQPCQEICNLTDGALTSLWHTHWHKPIQKCNLKEDLKLTFDLGNVYHLEKFEYTPRDDAGNGTFLKIQYRYSIDGKNWSSLTKPIILEHNSSVKTVDLQGIKLRHFELIILDSVGDFGSGKQIRFYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQC6</accession>
    <name>A0A0N1IQC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459784">
        <property type="protein sequence ID" value="KPJ19959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQC6"/>
    <dbReference type="InParanoid" id="A0A0N1IQC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="10932" checksum="F87ADB531DC38B50" modified="2015-12-09" version="1">MNIKKNIKKKSQRVIGPLDAEFDGKARTRESNTSKVNEYRVQTTTTAGAQRASGESPSSLHTTATTRRAYLLEFRELSENESSLAPKKPLLLCPSKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGJ9</accession>
    <name>A0A0N1PGJ9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ectopic P granules protein 5-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PGJ9"/>
    <dbReference type="InParanoid" id="A0A0N1PGJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="5">
        <location>
            <begin position="741"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="4">
        <location>
            <begin position="1332"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1854" mass="205745" checksum="9C45EC8596AE0596" modified="2015-12-09" version="1">MDHEGTTISQGFIQEEKSRSLLWKIEKERAYASENCPSCAKSLSVQVTFETATLQTEKIPAARLRLEALAREVQESYCHHQHTALMTYYQIEDLVYMTIQSGMGEIREALSLLLQAMRLSDGASEVYSASLQRWVVALAAKLVYTRDLRHLIFLIRHLFRQNRSVRWASRVLRVQVTDVCSAARAIALLELILARPGLETAVECTEELVEGWEEVGRSGEGSAVGEGLLRERDALALLRALPLRQLLAKMALFNRSDIESTEEHEWGDGSGGHGVLKAACGARALLAVLQRAVHAHAHYARLQRELTELCACALQLVAALHLRSRHVYHPEVAERVQVELEAVFVAGLLLHQGKDLTKLPATLLSEATARDYCFGLIATLHDKGPHRIASLDVDVGVVRCDVRVLVVLQAALDRADDHELARTLLQFLCQTAVKRKPQWCRQPCEVTARESLPRLLAVHPYLHAISLHVLADLNQGEPVDPTAVSYLSVQEWRPNYAEVLGVLEDWSVKCPHLIEHLLLQMEYTPHQGVSLETQLAMGAWLCEYVRRVGGEVREWAWSVLERLHVHRAQWAICSVGVRALVGVARVRPGVAARCLVSMMRAVQHTPESVALTPEFTEVFNVLLGSGPSLMARAFGRAGPATAELLEKALLNELLSSQSQNPGILNPWLRGLWAPTLPSSARALLDTAVRAVEDVPAIDTVVSLMLQGENSKEFLDDAVRNCSVAPLLCEAALRGAHAQYELSAHMWPRLTDAVARQRAHGHKVHVDNAIKQIGCTISSEELVVYRTASAVLSAPLRHPSHLTLWRLFFHLYLQRPPSSPQLTSIPVGPLFFSGIIKSRVLSQLKKRLQEVIDYHKIQSEQLKIEVYPQTEQIPTTSDSRKTNITKTYDRKLFAPITINDLIEEECRNDSESESSEEEITEERVSESSATREKFHLYCYHSGAVKMLSEYGSWLSDGDKTRAAPHHADIARFIQHEGLSAARRNSLPVWFVSATPPRPHAPPTQPTPLQRAIDALLQIKEARALSPLPDIQPLLDEHNNLSDARVIYNLVDRHLRTMESDAQSWSREVSQLSQLDSKLLELLRALRVRRPLPTYTKWCGNDTCKPIKITLQVYFHCNRRCALAALRALSRPRPSTARVAATLQSLVRVVRSRETAVRVAERAGNSAAAVHSFPPAIDAITSLVTHLAERWVCGDAGACGRLLRAWAGGGAHALCSALVQPRRLDHTSFLELYHTVLTASLPPPAAFSYLSRFEMATWAERVDPVQREKMLDILVQAAQRWGPAPEPEHHVLLELIGVHIGLVCGVGEVCALVVGGLRACARGSLPPTLCAHLTHAAAHAHALTYNQLGNLLREVGAIWWETRTSLTEETNLYVPYASHLADILQVLQQDFTAATKALGHDTERVSWFAWSVLREAWAPWVQPGTPPPLLPVTHSEDSNAHADMLQRFRETLQLLIDGCPGSEEYVLRHVWEWAVHTYIGAGARAPQSCRVSLSALLSALESLPWHTVQWMHASCMPLALQISRCSDREIVSWCGARWRCACAASWVRGVQDAHLAPHLAALLSVFCSPQLQLDTQVLEEAALLPWQRLPEAALDAAFEQFFVDFHNPAFPYHETMQFRLLLCASQLIIVGETPECGVGARARRARSVSQCVRAAATPTLTQHARAHAETMLRVLTDLGSEGGGWCALRTRLCACAWGGGAAGAAGVRRGWHAASDDEPIMAVWVCVLCRTALQSRRVTAVSADMSECVEVSRGVLVRWAAEPRRSLLQLVAMHHDTHTVRIRLLCRLALCILDPSSEEFVKAYEASCSALPPGQVEAVSWGRAPGAKYLPRLAAMLYPGRDVYFDEEAKLLQQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGL9</accession>
    <name>A0A0N1PGL9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_03220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ06989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGL9"/>
    <dbReference type="STRING" id="76193.A0A0N1PGL9"/>
    <dbReference type="InParanoid" id="A0A0N1PGL9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="295"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="381" mass="43865" checksum="649BC06032F0EF78" modified="2015-12-09" version="1" fragment="single">LPKEFEKNTEVLPFTKYGLSTLKDFSKAEKDIQHLEWLKKVGLSNEEVKLYQENEAGLLDQRKKIESTVLKSKLDEIYNKINNFQAFGSSKQNSEAPSTSTSKNEQIQETKTKRPLQFYPEGHPMHELKEIEEDLFGHLRNDNIMPITKRRKLLRRLERKKEKVMAQQKQLQLVPTQNESQPSTSKPGSLWDIKDMPERLPECSTSTEVSKNAIKDKIIGPKKQTMYTVKDNKILRLEPLQKDKDNETRNEFRAVDIVMPVNPAEEQLLEGTKMNLDDIKAIERFKDYEPGIPSKVLYLKNISPAVSQERLSLLFNQFLLDNGGPIDLRLLTGRMRGQAFVTFQNENLAIKALDEVNGTILSGQPIIAQFGRNSNRIQDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH32</accession>
    <name>A0A0N1PH32_PAPMA</name>
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        <submittedName>
            <fullName evidence="10">Zinc finger protein 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460077">
        <property type="protein sequence ID" value="KPJ17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1PH32"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="576" mass="65146" checksum="1AB577FFAE760219" modified="2015-12-09" version="1">MWVKVKPEFSSVCGADREVDSQLCRIDFHLLFMKCFQGSGTLGCYDTRCTIHKTLFILKNDRLPQKICDKCSCKVNDFYQFCNEAIEVQSKLRSILIASGITLGDSDNCSATEAESYSSTLKIKVLLEQETQTERDEPTNVKVDVKVKEEKVEPKPSPPQLPVKTENDCSDSESSAGSNAVLSDASDDLSLFSLKEIKRIENGNTTKNGQVQENRRGRKRKGKLKDFHLLINTLNSNSALTVLTKKDRNRIADDENRKIKTEEIDTDVQKKNKRSKKGEQPQDVYQCCICFDKFYARPDILQHYKSHASAAPPAPPPAAPPPPPGTPPLKCPRCNKEGEWAAHWRRHWRRDCQPFRCGLCEKTFRDTYQLFRHGLGHEAAGAQPDKRFVCDVCPESFVYLRCMLAHRARAHPEAGGAVALRCRLCARQFAHTNSLRRHLRSHTGERNFLCSVCGKALSSAEHLKYHLRIHSGYKPNVCGVCGKGFVKKCNLTLHERVHSGEKPHVCPHCGKAFSQRSTLVIHERYHSGARPYACARCGRGFVSRGLLTMHVKSRCYAPDDCSWTLRHCSWTLRHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHE0</accession>
    <name>A0A0N1PHE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_05469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHE0"/>
    <dbReference type="InParanoid" id="A0A0N1PHE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9888" checksum="F4C56B4D139FF50B" modified="2015-12-09" version="1">MSIKIATLQYPDACPVRFASRKRSSTVCPRNDSRGRSLQIALVLGRRPRSEDRLSLSAAAEGAERDAATDRGILITGTARTGRRYHQTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI33</accession>
    <name>A0A0N1PI33_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460480">
        <property type="protein sequence ID" value="KPJ14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI33"/>
    <dbReference type="FunCoup" id="A0A0N1PI33">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PI33"/>
    <dbReference type="InParanoid" id="A0A0N1PI33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11497">
        <property type="entry name" value="SLC6sbd_SERT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF279">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="739" mass="81701" checksum="392B5A41D00855AF" modified="2015-12-09" version="1">MRTPGEKNCGPQMIGPICEDHRFCPQGESPGPERRNGECEPPAVDMAATPPAPAPAPAPARDDHAPPPVQPPQHQKTRSIVVSLTPARERETWAKKVEFLLAVVGFAVDLGNVWRFPYICYQNGGGAFLIPYCIMLLFGGLPLFFMELALGQYHRCGCLTLWKKICPALKGRTLKPSGVGYAICMIDIYMGMYYNTIIGWAVYYLVASLASLGSQLPWTSCDNEWNTPLCTPITSPQIFLNATTPAKEFFERNVLEQHRSNGLDDMGPIKPSLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYAVLLILLARGVTLPGATEGIRYYLTPEWHKLQNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFDNNCYRDALLTSSINCLTSFLAGFVIFSVLGYMAHVQNKSIEEVGLEGPGLVFIVYPEAIATMTGSVFWAIIFFLMLITLGLDSTFGGLEAVTTALCDEYPRVLGRHREIFVAVLLLFIYICALPTTTYGGVYLVDLLNVYGPGLAILFLVFAEAAGVCWLYGVDRFSEDVRSMLGHTPGIFWRACWTYISPVFLLGLFVFSVLSHEEMLGGEYTYPRWSIAVGWVMTGTTVSCVPLYIIYKFIITPGSCYQDLATRRGSTMVTWLSCNGEGWGMGPTAVFASAAALFLYSELQATINSGGAPVRSTMLENTLISTMVMGMLALMVHLWVCFTRFFLYYLDTLIRDVSIFNPYINIYSNNFSKNATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIA6</accession>
    <name>A0A0N1PIA6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460460">
        <property type="protein sequence ID" value="KPJ14652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIA6"/>
    <dbReference type="STRING" id="76193.A0A0N1PIA6"/>
    <dbReference type="KEGG" id="pmac:106711253"/>
    <dbReference type="InParanoid" id="A0A0N1PIA6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="156" mass="17528" checksum="B6933515F8EF79AF" modified="2015-12-09" version="1">MENSITLHILMNDEFTLSKKRVAKYLFGVDSTLAYTNKDYERLVGDFGLRKQVKLPKDKLGVCISLAMETNGTVWAGGKLSGERGAARRFATVVGSRVSRSGRVCSTARCECRSARLHCRPCRPDRDPLELSFWNTEDIDELIDLAMDPPNLPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJV7</accession>
    <name>A0A0N1PJV7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hyaluronan-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_00666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035384">
        <property type="protein sequence ID" value="KPJ21286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJV7"/>
    <dbReference type="STRING" id="76193.A0A0N1PJV7"/>
    <dbReference type="KEGG" id="pmac:106707604"/>
    <dbReference type="InParanoid" id="A0A0N1PJV7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000078">
        <property type="entry name" value="Serine protease H137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ21286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15021" checksum="F55DF17D7DC1620A" modified="2015-12-09" version="1">MRDLREKDLAKESATVAGWGATEDREQSNILLKVEVTIYSETTCKSFYKGYMQSRIFKPNMMMNTICAGDEGRDSCKGDSGGPLMIEAPYNGTYKFVQFGIVSYGVDQCGLKKPGLYTDVRKYMKWILDTIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK00</accession>
    <name>A0A0N1PK00_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459718">
        <property type="protein sequence ID" value="KPJ20253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK00"/>
    <dbReference type="KEGG" id="pmac:106708767"/>
    <dbReference type="InParanoid" id="A0A0N1PK00"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="457" mass="49765" checksum="A0998D2AEC101103" modified="2015-12-09" version="1">MVYSITENKDHGQKKFVVWKRYLISVFASIPFITHGVENDLLSATSHLAPVIVAAGVPWTDVTFLLAALISAPAHGLLIDRHGRRIGIYILVLLQGMTSVPLLFSTSELSVLVHAAVAGAATGGLFLVLPVYVREISGDAVRGVTLALMMPMTSLGNAMKLLLTFDQMLFLVLGLVALELFIVFLIPESPAYLVKADKIEDAKVVAAKLICSNSDDSLVVDDITKLKEESDRANANGKLTLFQILKNNIYRDEIKIGLVLNTTLVLSGSAIFLQPEKTLAGLGDDIDPRRLLVPLALLAGAACTVVLAHFFERKYVLTGACGVMVLSMGTLAVYTQAGLPVTSLRWAPQAALAVLVAAYGMLWALPTLILVDMLNVEIRVRAMTVVYVYTQVIRLAQTLSLQHIEEYVGVYNLLYMYAGVNTLAGVYALSSPPAARGRSVRHIERQMRARRVPLWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKZ4</accession>
    <name>A0A194QKZ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAD homology 1 Dwarfin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKZ4"/>
    <dbReference type="InParanoid" id="A0A194QKZ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MAD homology 1 Dwarfin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="18836" checksum="07314FEEB273A4DD" modified="2016-10-05" version="1">MFRRRALRRRLAAAGAPSVPDDQLRGLARALDAGPGGTACVPGAALRLPAARAFLHPELRDLAELRRLPLCSDHRCCNPYHFSRLCKPVKIDSYVEYSEATLRRGMRVSRRRAAACRRGRYLFRHNCSAADWRRRRRAAGRRPAAGRGAGARTALAQVRHKPVSTFVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLT9</accession>
    <name>A0A194QLT9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLT9"/>
    <dbReference type="InParanoid" id="A0A194QLT9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8312" checksum="ACDB42507814F63A" modified="2016-10-05" version="1">MPMSSNGQTETDDDDNGKTGATIHNLHGQYDTCGRQVSERKGLPDLVIWTMYRPTTPREVTVVDGAQLIIASPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMH7</accession>
    <name>A0A194QMH7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMH7"/>
    <dbReference type="InParanoid" id="A0A194QMH7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="14325" checksum="52B5BD4201726C8D" modified="2016-10-05" version="1">MYPGVEHFNTSEKWKFNDSSCIENDNVQNLEHNLDRIRSLSHERNFIQYGGKDQLLEVEVNNVVEDDSDESKDCTSVGCREGFDEKGEHVSVPKFSRHSSLSNRELDVIKESSRSSSDTEVTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMM7</accession>
    <name>A0A194QMM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell death activator CIDE-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMM7"/>
    <dbReference type="FunCoup" id="A0A194QMM7">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMM7"/>
    <dbReference type="KEGG" id="pmac:106719678"/>
    <dbReference type="InParanoid" id="A0A194QMM7"/>
    <dbReference type="OrthoDB" id="6475906at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015121">
        <property type="entry name" value="DNA_fragmentation_mid_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF15">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09033">
        <property type="entry name" value="DFF-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="197" mass="21802" checksum="DE57C8F1FD349BDE" modified="2016-10-05" version="1">MENDINKPYKICDVNRDKKKGIVASSLEDLLAKVPEKLGVPSENLTVVLECDGTEVDDDEYFSTLDPDTALMILHGNEKWAPNMPKCQVSLDQTDEVTLGDKGQVANLVGRLQHNLCHISLLGGQDLELLSDMDPDSLADIVTDRDNRIILEHIKEASGRILLEKRQAQDAMELLKLYHQSVANGNEDVSPPSQEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ46</accession>
    <name>A0A194QQ46_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ46"/>
    <dbReference type="InParanoid" id="A0A194QQ46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037355">
        <property type="entry name" value="COMMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="8870" checksum="7FB5BA742ED4F2F0" modified="2016-10-05" version="1">MSTSQSDANALPRITDVEWKLEALTNTPGVGSDKLLYSVVLKTDKDDVPFTCDTQQLQDLVYKLKDLVRHCENVKSELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQP4</accession>
    <name>A0A194QQP4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc metalloproteinase YIL108W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQP4"/>
    <dbReference type="InParanoid" id="A0A194QQP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="564" mass="63813" checksum="0858FBBB662F2366" modified="2016-10-05" version="1">MTTVLTHSACDNLQVMDNRTLEENKNENSAIFVTNFENGDVINYSLVIIKGIITSGDCSNYKKLKCTFRNNDTQKNSQWDVYNREFKVLVELKKGENVIDLDYAERHHKSLILNYAPRKTNLRVTPLYIVCQGHDGCFQSPPDVDNSIESGCSRVAVGSKLIQSLTAEKLYESGVGRKTFQLEHEVNPRKPECIIFKSNLNVNKARKMKQGELWTHFGREIMLSDLGSNERKYLAFLSCTRYKGTDIDKPMTHDEIVALTEGYAALGGGGLALFGTACLYTWPTCVEEIVPKFLDCTPVNVRRFMDDSGYRSTLGGCFATTLGSVFHELGHTFDLGHTKDGIMGRGFDNIDRVFLVGEKRSMLTKDNMNNFNGKPVQHSTVSLQRNINVTMNVAEPLRVLGPRSKTTLGNFASMSKSDIVRRSPNVTPITRPSSLYSSVTNKLSESRKNMSKSNGNDSIYWTRNCAVLLSYHRWFNNEYGRERQAITRYLKFDKNKMMIISTAGIRIVEVRDESNGMVLDSYEFTNLLPEKRFLVPFTFSPKSKVLTIVVEDDLGNVLKQTFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQT0</accession>
    <name>A0A194QQT0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQT0"/>
    <dbReference type="InParanoid" id="A0A194QQT0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="15032" checksum="1B1D0F31970A1B13" modified="2016-10-05" version="1">MVFLVRDALCEVYRFCGRTPKVCSAEKLRGEWIDRAERILFLGTITRPYAYNVRNHPCCQEPSENLTLGMIIDAYEIYGHDPTDKLDFLVHYQIEMMKIKRARDQVSCIADDDDDDDRMFIIFSTHTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QRU3</accession>
    <name>A0A194QRU3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Facilitated trehalose transporter Tret1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QRU3"/>
    <dbReference type="STRING" id="76193.A0A194QRU3"/>
    <dbReference type="InParanoid" id="A0A194QRU3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="43072" checksum="82DC2231A98CBFF9" modified="2016-10-05" version="1">MDRGKGAQYLVAFSVSLATLTMGTSSAWPTIVLPRFHHNETNVRVTDDVASWMVAMSPLGFLSGSLVTRYISDNFGRRVTVLGSAAPIAFGTIFVIYSSYGWMLCITKFLWGFGTGMLSTALEEELQIMQNGVKNAMRSSSSAKELFTGKQYRKAVIIAAGMKMTQILTGGMAIQQYLIVIVQESKFKMAPATISIVFGAVKFGVSLISSILVDRVGRRPLIIYSLLGTGISYAVIGFYFFLLDVVQIEHESLSPYGILTFIGILISTIVSTLGFNSVIGIVPAEIFPLNVKAVAMTSLNILGGLLGFAVGKGYQLMKNLLGLTGVFWIFAFVTFSGAVFTYFYVPETRDKSLHDIQILLQGDLYIDNANVNKDILVEAELIELNRVKDVENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTB3</accession>
    <name>A0A194QTB3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_12307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTB3"/>
    <dbReference type="InParanoid" id="A0A194QTB3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="145" mass="15839" checksum="8D3199DDCC39996C" modified="2016-10-05" version="1">MSPKAESVDVSSPIDIARPDYMNGSIKDANDAKEKDKNVQNVSFFTLFRFASTLDKIYMFLSILFSTLCGITVPLSVILFADVLQAMVNYGQSVVAGAPENEVFLKAITDFVIYNCALGLVAFIISYAATVLMNVAALNHINENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTF1</accession>
    <name>A0A194QTF1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dentin matrix protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTF1"/>
    <dbReference type="STRING" id="76193.A0A194QTF1"/>
    <dbReference type="InParanoid" id="A0A194QTF1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="254"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="476" mass="54262" checksum="DD8F43CC7164790E" modified="2016-10-05" version="1">MDYGISGHRVPLHGRVRIGDDQDKGRSAYIEFRKRFLQKSNGSNGSREFEQSAPSETSGGGEAEPRTPAPPVDHYEDLVKIINSQLTGHNEDHPVVVPPHHDLNVLRPENPTIGEMEDLEPSVNASNLEKFQLRIAQHELYEDGEALVDAVLKDMATLPILHAEQKEGGTQLKLIIDYPNGIQALFKPMRFARDVQTLPNHFYFSDYERHNAEIAAFHLDRILGFRRAMPVIGRVLNMTTEIYDVTEGDILRTFFVSPANNFCFHGKCSYYCDTGHAICGNPDMLEGSFAAFLPSPDLAERKVWRHPWRRSYHKRRKAQWELQSDYCDTVRSTPPYDSGRRLLDLMDMSIFDFLTGNMDRHHYETFKMFGNDTFTLHLDQGRAFGKAFHDELSILAPLLQCCIVRHTTLAALLKFHNGDPLSKVLRESMNADPVSPILWEPHLAAVDRRIGLILDAIRKCIEKSENPLQDEVNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTH4</accession>
    <name>A0A194QTH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTH4"/>
    <dbReference type="STRING" id="76193.A0A194QTH4"/>
    <dbReference type="InParanoid" id="A0A194QTH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="32994" checksum="5DEA633C7D18450F" modified="2016-10-05" version="1">MEFQDKVVLITGASSGIGAATAIYFSKQSAKLALVGRKENNLKAIGVYCLKAKGIRPLTITADLTVEADVERIVKETIDHFGRLDVLINNAGIVLMGGLKNSNMEIYDKVMATNMRSVYHLTMVATPHLIESKGCVVNVSSVSSSMPSAMSTAYNISKAALDHFTKCAALELAPDGVRVNSVNPGFVKTNLYKNVGLNEDQLNLVAQNMVGKNPMKKAIEGEEVGVLIAFLASDKAKTRLRLHIGWDQSQSEAEADADAEACVCQGGVGASTSFCNDPTRSAEAPTATTPGRAGAGAGRGTGAGRGESTVTHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUE6</accession>
    <name>A0A194QUE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase/reductase SDR family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUE6"/>
    <dbReference type="FunCoup" id="A0A194QUE6">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUE6"/>
    <dbReference type="InParanoid" id="A0A194QUE6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="28328" checksum="53065F429B59364D" modified="2016-10-05" version="1">MTSVHQHLLNANFHSTRLKGKVAIVTASSEGIGFSIAKRLGNEGASVIISSRKEENVKKAMESLRNEGINVEGIVCHVSNADHRKLLFETAKSKFGGFDIIVSNAAVNPSVSPILETEEKVWDKIFDVNVKSAWLLAKEAYPELIKRGGGNIVFVASIAAYQPMNPLGAYSVSKTTLLGLTKAIASEIVHDNIRVNCVAPGVVATKFASAITSSEAGKEKSLSIVPMKRFGKPDEIASAVAFLVSDDASYITGETLVVAGGTYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUH6</accession>
    <name>A0A194QUH6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pancreatic lipase-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_12383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUH6"/>
    <dbReference type="InParanoid" id="A0A194QUH6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="358" mass="40396" checksum="89EE483339661595" modified="2016-10-05" version="1">MSKLHRPWRTPDIPSDFPRKGEYPCKDGICKTKKPCPGSTKPITIPRSQLKYLFFVVQGKGGTRQRYSYWNAKKIATDPRIDFNRKTIVVAIGYLDSTNFPISAMFANEYEARDYNVILVDNQRFATVHYYLATRLMRPVGLHVAQILAQLTEAGLDPSKLEILGFSLGAHTASYIAKNFQFLTGKNISRIYGLEPAGPCFRDLNKNDRLDASDADFVQVIHTNIDAFGMAASMGHVDFYVNGGEYQPSDLNLFPCTGTCSHFKVLPLWLSALKNPTRFIAIKCDSIQQARDAKCYDRVPLETNFMGPKVDVTKHGIFYLSTSKFFPFYLGKNGLKEEYASWRTISDINDSVGTEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVA3</accession>
    <name>A0A194QVA3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Suppressor of cytokine signaling 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVA3"/>
    <dbReference type="FunCoup" id="A0A194QVA3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVA3"/>
    <dbReference type="KEGG" id="pmac:106717315"/>
    <dbReference type="InParanoid" id="A0A194QVA3"/>
    <dbReference type="OrthoDB" id="6426624at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10388">
        <property type="entry name" value="SH2_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03741">
        <property type="entry name" value="SOCS_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035866">
        <property type="entry name" value="SOCS7_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037346">
        <property type="entry name" value="SOCS7_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF5">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="378"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="478"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="535" mass="60853" checksum="6194CD5F52427FB4" modified="2016-10-05" version="1">MYPRKLKPEALYERRQGYNHRFASPRLLHLSPCRGTRPSSRNSLTSRLSSSHNSLITQFQADDSNFITQAISHDTLSAKTSDITDMYNVPFDSDIYAVPIDMVRPSHSTTRGKPKKPSRPNKRRGKSTPQNIGSNFTPLERSHKPKDFSRQKDSKTKRHSLPSSSVKKNTTDSDTDSLHLTLREMRKYLHTLYSSSSDSECRNTIHKKSNTIITNVGIHMRHTNNKESATTVFIKDNKDISRTVETNNNHRNTNKNSVGTTTKGKKHKENVPKEIPEAEKPEKVTKKASNPKTKMSPVRMLSMNLKQSFCNLFRWRRSGSEEASSASLPAPAAGRAVTSSPPAAVRRALPPLPQSPQSPHTTHLDFATSIQKVKDYPWYWGPISVEAAEKILSNEPDGSFIVRDSSDDHYIFTLTFKLNGLRHVRIEHDQGNFCFGGCTMFKAQTIVEFIENAVETSRSGRYLFFLNLRPVLGPVRVQLLYPVSRFKRVQSLQHTCRFVILKYVRRDLISSLPLPRRLLDYLSATHYYSELLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVE6</accession>
    <name>A0A194QVE6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVE6"/>
    <dbReference type="InParanoid" id="A0A194QVE6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="87" mass="9737" checksum="6E02F19A916D41B4" modified="2016-10-05" version="1">MGPSDALQCGAVRYGVMLRGGGEDARVWAAGVGRARASSPPPHRWYTNRKQFGYDFKTIQYITIFNNKNITSLIHDIMQSFTPKTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW27</accession>
    <name>A0A194QW27_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A disintegrin and metalloproteinase with thrombospondin motifs 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_13148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW27"/>
    <dbReference type="FunCoup" id="A0A194QW27">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QW27"/>
    <dbReference type="InParanoid" id="A0A194QW27"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF275">
        <property type="entry name" value="STALL, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0401">Integrin</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="277"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114072" checksum="E1B29050E1685F52" modified="2016-10-05" version="1" fragment="single">NKQLLDHLTESERLFLIGANSDNAQIMAHTCVFLGLNSTRFRLTEHNKQLLDHLTESERLFLIGANFDNAQFEILHLRQKKRHKRSLHHDNPDLNSLKRHLDLKLSPRNTFLDPQFLLMRRWTNGTEAVLDQHNDDELDLCYYRSNTAALYACGDFRGLFKVNGSYYYIHPLPERFHSEETKPHVIVKRHLNDETVNNDINNINTCIERNSSNKTDTVQSVKTWTKHRRKREVDNNKNVTLEQFKFNLAKRNKTINEFIEKLQPDSNRQKRAITPPIFVETAVFVDRDLYKHMTVNFPKDTERELVRFVLAMINAVQLIYHDPSLGRTVNFILKRLEILHEDPVNLKRPHDIDRFLSNFCTWQRLENPPGDNDPLHWDHALILTGLDLYVVNKNGKVSSQVVGLAPVAGMCTVTSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPLADNGCDPSAYIMSPTLGSGKITWSQCSRNYLQKFLDTVQSRCLLDHGNSAGQLDHSAEGILPGERFDADQQCMLKYGSGSRHSPAQNLEDVCRDLHCQRERYTWTSHPALEGTRCGGDMYCRGGACVEREGAVREGRGAWGRWSHWSECASACLLDDKHAPAAAGVAVATRRCNRPRHENGNNYCTGHDKKYQSCHAQQCNKVPRMTVREFADQICLRARDVDPDLIGTGLQRIDSEDVSSACAVWCDTRGGGYKSRGWSLPDGTACSRAQPMFCISGLCQKFTCDSSSDNEFSLKPGDCEWEALQLQTATPHTTSTKTSGTWRRAVGSQWRAASGCHYHCVSPGSGVRLVSSARHTTIQLCRPDAARPELGCLQRKSPYQYATMVCSKYKERVRRLSGLGMQISPVLEDPDRPCRVACQDERVAHRFYLVNGQEGWFPLGTSCGKRNSSYCVSGKCLEFGADDTPLSESVFTLPLLPRGRTSRHRRALHRNRLTVKATLDQLHLQDIIANLNFTGKTDQHIIYYDTIPDNIELDFNNPIHISPEDTLNRKIPHPTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWI4</accession>
    <name>A0A194QWI4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWI4"/>
    <dbReference type="FunCoup" id="A0A194QWI4">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWI4"/>
    <dbReference type="InParanoid" id="A0A194QWI4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF482">
        <property type="entry name" value="FI23944P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ07931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="262" mass="28242" checksum="9C8DF7E2E7A271E7" modified="2016-10-05" version="1">MAIGAGMSCVKLKFKIKKKKTTKMAIGAGMSCVKYLLFCFNLLFALTGLIILIVGIWVEANSHPYIDLTDESFYTTGPVVLIIVGVIVFIVAFFGCCGAVKENHCMIVTFAIFLLVIFTAELAVGIAGYVKHDDIQNSIVRHLNTTIKDYPTNKEVQSTFDILQTDLQCCGIYGPGDWANNTLPIPETCCAGREIKEGAAAACTPDSPGFHTTGCLSKLVPFFNDMAVLLGGVGLGIAMVQLLGVIFACCLARSIRSEYETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWM2</accession>
    <name>A0A194QWM2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED9</name>
        <name evidence="12" type="ORF">RR48_12813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWM2"/>
    <dbReference type="FunCoup" id="A0A194QWM2">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWM2"/>
    <dbReference type="InParanoid" id="A0A194QWM2"/>
    <dbReference type="OMA" id="ESQDCNH"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="116" mass="13802" checksum="5BAEC144862B5065" modified="2016-10-05" version="1">MENNSELSDPNNFSPLTVQDVDVDFLPIVYEIIRSIERDFHDNSAKARESQDCSQKVLELQKKFDVARSQIKRLPGIDYNKQDQLKQFEILRTQLRLKRELLQKYRNMCSFETSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ30</accession>
    <name>A0A194QZ30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein MAK16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ30"/>
    <dbReference type="STRING" id="76193.A0A194QZ30"/>
    <dbReference type="InParanoid" id="A0A194QZ30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="47626" checksum="8D7E4EF5B1C9C0B0" modified="2016-10-05" version="1">MQHDDVVWAIINKTHCSHKVTTKTQHFCRNEYNLTGLCSRSSCPLANSKYATIREENGNAELLPLHACLLIMFPAKQWEKVKLSRNFEKAIYQINENLLYWPAFIQSKCKQRFVKITQYLIRMRKLKLRRVKELVPIQRKIERRERRREEKALVAARIDNAIEKQLLERLKKGTVVWAIINKTHCSHKVTTKTQHFCRNEYNLTGLCSRSSCPLANSKYATIREENGIIYLYMKTAERKELVPIQRKIERRERRREEKALVAARIDNAIEKQLLERLKKGTYNDIYNFPQMAFDAALKAEEISGESESEKEDEDEQEMELEPELEKELEKAVEETDEFIEANSDMDSDAESDSGRRENVDVQSDFESDTSDIEDMSVKITSRKKPRVEIEYETEPIASVSRKKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZ35</accession>
    <name>A0A194QZ35_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZ35"/>
    <dbReference type="FunCoup" id="A0A194QZ35">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZ35"/>
    <dbReference type="InParanoid" id="A0A194QZ35"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="189" mass="21370" checksum="2D284A2435C24CFD" modified="2016-10-05" version="1">MDGNRRFAKKNSVQSSVGHHKGFDKLSETLKWCLDLGVPEVTVYAFSIENFKRSEEEVAAIMDLARDKFKRLLDEIELINEWGVRIHVAGRLSMLPEDLRSLVAKAMLATKNNNILQLNIAFAYTGRDEISRGASHIIDGIRNKDLLPEDIDEDLVSQTLDLGEAELLVRTSGEVRLSDFMLWQVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1I2</accession>
    <name>A0A194R1I2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1I2"/>
    <dbReference type="InParanoid" id="A0A194R1I2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="21633" checksum="4156CFC600810D53" modified="2016-10-05" version="1">MAVDLVNTNDNLIDRCNEYDCVTNVVYEAEFSEDFKSCKDFDNKYIKCESFMLGLVEGDDDAEGGLGVSGVLEMSQNIEMGYKISMEVWKLMDVGKEFTFGSVADVCESLKSEEAPWYPLVVSMNVTDCPVPAKTYPIQDLLISLEFAKDFLCVEFCGEYEVILSVLNENDEQLSCYVLGISIMETEKDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1P1</accession>
    <name>A0A194R1P1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fanconi anemia group J protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_08349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1P1"/>
    <dbReference type="STRING" id="76193.A0A194R1P1"/>
    <dbReference type="InParanoid" id="A0A194R1P1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="77"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="763" mass="87115" checksum="734C762314782D5E" modified="2016-10-05" version="1">MPELRRYNQDPSRCSTYRKIALFLATSQTPPFLTLPTMYSQKSIYDEASQYPKDASNRASKRQDCPDTSTEENNEAGLVKIHKKRRLGASELGMFCESLYDSQLPSTLAGTELPSTPEKKKQTPQPDTPQNVRVLYNLVDNLRLRTSMLVDCSVPTVYYGARTHKQLQQVIKEFARTDYCGQLQMTVLSSRDYSCVREFDKKTWSTRNDMCRACVKPYTTKSIEQRADSNCKYYDNRGSLNHQTLPPAFDLDELIAKGEEIRACPYYAARGMAASAHIVFCPYNYLIEPSIRSSMQIDLSDNIVIIDEAHNIEDICRDAATFTFTRDNVQASIKELEVVAGYRFANQDALRYVEFLLRAFKGWDDWFVNQTPFINQKPMTGNEAVFTWTAENFVQTLNNHNIGQQQYKVYRKYFMSTSYKTLLVLFVYRFFFLNVCNFVWVSYLFQSILMLVKFENVCLLIVSIWFVLKSIEKETLSLRLLCMNPAVVFDSLKVARCIILASGTLTPLISLHSELGTDFPLQVSPNHVIPPDRVWIGSLSTCPGGGRLECSARGAGETRVQDGVGAALRCVCRVTPHGVLCFLPSYTLMNKLVNRWKETGLWGELNELKQVFMEARNARDHSDVMEEYYSSVCGGRGALLLAVYRGKVSEGMDFRDHQARAVVTVGVPYPNTYDMAVKEKMKYNDRYSAQRHLLSSSDWLLVQAYRYIIIIIISSLYILTEGLGTYPKLRLGNNHHTFESLVNSPNSLESFMQTMTLRESEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R207</accession>
    <name>A0A194R207_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mid1-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R207"/>
    <dbReference type="FunCoup" id="A0A194R207">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106714382"/>
    <dbReference type="InParanoid" id="A0A194R207"/>
    <dbReference type="OMA" id="KIARNDN"/>
    <dbReference type="OrthoDB" id="5951908at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF17">
        <property type="entry name" value="MIP21584P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="167" mass="18608" checksum="7C3184F8A36C393C" modified="2016-10-05" version="1">MSFNTDISSKLESSRNTLRKIARNDNTEFSKQSILNDMEKFVKMVNTMDETVLVPSRLMNLPQEGDDDPFSMFAMLNDLKTELLWAGDVEEQGDRARRVSDLSDNESDTSSAAGDSGIEGEDERESAVRAAAACRRHLRGLRHSLRQLTAAAAHLTRTYQEEVGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2C0</accession>
    <name>A0A194R2C0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2C0"/>
    <dbReference type="InParanoid" id="A0A194R2C0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="52" mass="5936" checksum="1804870E9C96CC98" modified="2016-10-05" version="1">MGAKESVEAAKFSAQNWNNFEHGVVKHHYRHGTQRSQSLNRGHSLSRTDGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R572</accession>
    <name>A0A194R572_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R572"/>
    <dbReference type="InParanoid" id="A0A194R572"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="315" mass="36210" checksum="FF2BECE1BB3796A2" modified="2016-10-05" version="1">MDIRNTRGTADALPAFTPIGSPSRTSSATRLFDKLRTRICRSKTLFVHQEEGAESVITEPSPRNHRSTNLLKDHALSECTTRTILNDGRSEKYSCHLCSFDADRITVLDRHLLNHHKIGLENLLKLVMSKTKDGLSDDAAIIDEYGVRQPYYKQADDIIEEGEFIIETVTPKIKILKHAAVNTDLKWNDIPELKNNYRMIKKELERLIDSPIEDNQKDKLLLKMQSLNECMCKFVDSSNTLKKVLTKNILKNEHASGPVFSLGLGELVLHSINMIIILYIELLIFKTYCSQETPREWERPHSEKLERNKCKHDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R5I7</accession>
    <name>A0A194R5I7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_10409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R5I7"/>
    <dbReference type="STRING" id="76193.A0A194R5I7"/>
    <dbReference type="KEGG" id="pmac:106713224"/>
    <dbReference type="InParanoid" id="A0A194R5I7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="11382" checksum="D79C384B399D2E62" modified="2016-10-05" version="1">MTGRGKGGEGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6Z7</accession>
    <name>A0A194R6Z7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6Z7"/>
    <dbReference type="STRING" id="76193.A0A194R6Z7"/>
    <dbReference type="InParanoid" id="A0A194R6Z7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="143" mass="14949" checksum="E0278A0158CC6BC9" modified="2016-10-05" version="1">MAVGVADPLLADPAAPTPDGPPPDLIALGPLHVSADTVVGELECARFFPPGYSQPQPKPKVKAKKKKKKRQEVKDEDDAVPEAAEDAEVNGEDDGRRETEDGEGEGEAEGEAEGEGEEAEGDEAEEDQALVADKATSPPPVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7P3</accession>
    <name>A0A194R7P3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine string protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7P3"/>
    <dbReference type="FunCoup" id="A0A194R7P3">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7P3"/>
    <dbReference type="InParanoid" id="A0A194R7P3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061177">
        <property type="term" value="C:type Is terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900073">
        <property type="term" value="P:regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="24129" checksum="853D07A7F6741F27" modified="2016-10-05" version="1">MDKRKLSTAGDSLYQILQLPKTATPEDVKKSYRKLALKYHPDKNPNNPDAADKFKEVNRAHTILSDTTKRNIYDNYGSLGLYIAEQFGEENVNAYFVVTSTWCKALVVVCGILTGCYFCCCLCCCCNCCCGKCKPRPPEESGDYHTLERDDSDGVQAVTVQPGGEGRPAGEQAPPIAMPAPPPNVASAASENTGLNTGGEAVFPNTHEVITSSVIIIREMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7T4</accession>
    <name>A0A194R7T4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7T4"/>
    <dbReference type="STRING" id="76193.A0A194R7T4"/>
    <dbReference type="InParanoid" id="A0A194R7T4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF5">
        <property type="entry name" value="HL04814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39031" checksum="0E65EE522BA11EA1" modified="2016-10-05" version="1">MAVARDAALGNAAYGLLLHERIRGIYHHNLDFVLHLSNITSLILRAFMQTWALVVCAAALAALTGAQKPGRFLSLPQPQKCANRPKEFFYRGHNYFFTGHVPSLANKKFDWLDGRNICREYCMDLVSMETQEENNLIFKLIQTNDIPYIWTSGRLCDFKGCESRKDLEPKNIFGWFWSANREKMSPTNQVFLVEEIEIVYVLHSWWKPKIIHDIPYIWTSGRLCDFKGCESRKDLEPKNIFGWFWSANREKMSPTNQIPNGWGYNPWSQTGHKKQRQPDNAEFDINGTTESCLSILNNVYNDGIAWHDVACYHEKPVVCEDSEELLNYVASTNPGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAA7</accession>
    <name>A0A194RAA7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAA7"/>
    <dbReference type="InParanoid" id="A0A194RAA7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265045" evidence="1">
        <location>
            <begin position="17"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="382" mass="44072" checksum="E64456EAF23AB9C1" modified="2016-10-05" version="1">MVFITIIFLVLAITKCSTPVKVSLQGQISVGKEVMETLSHFMDPDLTNGRRSMTPHEENEISKKITSKRLCQDLPLCDGRSSFVDNYLILLTTAVNSILKTSPIKELSLKLFYEDLPQILRDTRKILKSANAKVTDSTEFYYWNSIIKKISGKFHGFLTLTLTENFKDPEKTNNVKNIIQKIVTALVIIETKYANKLCIEHRICIKSFECTKALHRILEKLTNLPDNSIRSFMKHFYEALFATTFYSRLNIVTTKEFQVILNNLAFSNNVSAKDLLQSVQKSVEMRLELITNPSDKQMGYDVILIHIILSDLDHFYSKNKQFSFYNFIKYFIDWNTEGTLGKHLRKLMNDIGHEVTAQPHELPIKITNEVRVFLELTIDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB28</accession>
    <name>A0A194RB28_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB28"/>
    <dbReference type="FunCoup" id="A0A194RB28">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB28"/>
    <dbReference type="InParanoid" id="A0A194RB28"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="439"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="529" mass="57869" checksum="C6E335ADFE9B2BBA" modified="2016-10-05" version="1">MFGKAYKLKSNNTLKNSEKKHLAQRILNEFPAATDENVKELVPVKSNTSCMKLMLHSGESVGVYVVDNVPMMIETGDLLVPTVCALWKVPDLLPTLIIHSPVLPKLAGGAPLYAPGVTLSDAASFPRFPRGALVAAATADNSAAGAIGRAVISSTDLLRTTMGVCMETLHVFGDLLCKEPKFTKLERPKLQPPAYSPTADNITADIAQLNIQQPIREEWPSLVRESKDTPPTVKSSHSPVLNEPKTIPEEETQVENNEESEFDETVMTDSSQIEEDPVPTDMDELLQWCLLSFIKLEGKNLQLPLKTNLLYKNHLMPLCPSDRSLDVKKSSYKKMSKFLEAMQQEGLLEVREVEKGVKGTALSAAQVRAALAEHVRAHNLAAQHGKLRTDPLLAALVGPQESITWESAMSAVLGKMTPSTELHFPDGSVKLIKSRLEPIKMNVVTRSGNKKVTLVSNLESYGFRPGELAREVQLGAAASSGVTRSPGAKADQLMVQGDQTHFIAKLLIEKYNLPKKYLEGADKALNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBN8</accession>
    <name>A0A194RBN8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cytosolic iron-sulfur protein assembly protein Ciao1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ciao1</name>
        <name evidence="6" type="ORF">RR48_09049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBN8"/>
    <dbReference type="FunCoup" id="A0A194RBN8">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBN8"/>
    <dbReference type="GeneID" id="106710798"/>
    <dbReference type="KEGG" id="pmac:106710798"/>
    <dbReference type="CTD" id="9391"/>
    <dbReference type="InParanoid" id="A0A194RBN8"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="37553" checksum="A12CE79B46497003" modified="2016-10-05" version="1">MGRLELLQTLTGHKGIVWNVSWHPQGKVFASCGEDKIIKLWSKEGQDWTMKTVLVDGHQRTIREVAWSPCGNFLASASFDATTAIWDKKSGQFECNATLEGHENEVKSVAWSPSGQLLATCGRDKSVWVWEVAGDDEYECEAVLNAHNQDVKKVAWHPSLDILASASYDNTVKMYKEDSLDNDWSCVATLQSHESTVWSLAFDKTGERLATCSDDRTVKIWKEYRPGNPEGVIVDDKESVWKCVCTLSGYHTRCVYDIAWCPKTGLLATACGDDIIRIFKEPDNSDPNAPTFELVSTQLNAHSQDVNCVTWNPMGNEELLSCSDDGEIKIWKYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCJ1</accession>
    <name>A0A194RCJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trafficking kinesin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_09027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCJ1"/>
    <dbReference type="STRING" id="76193.A0A194RCJ1"/>
    <dbReference type="InParanoid" id="A0A194RCJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051946">
        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="103" mass="12261" checksum="42B7EF99D67C43FD" modified="2016-10-05" version="1">MTERRARPRPRRRNEMHDKQQDLLLAWSDEVCNSEEVPEVEIVSLLQEHIPKYRLRADSLTQFGGYENQDWFIPSPALPLSSEDLALTPDQIRETLNYFREYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD34</accession>
    <name>A0A194RD34_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD34"/>
    <dbReference type="FunCoup" id="A0A194RD34">
        <property type="interactions" value="1119"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RD34"/>
    <dbReference type="InParanoid" id="A0A194RD34"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048968">
        <property type="entry name" value="Apc5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21371">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5 N-terminal" evidence="17">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="16">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="16">
        <location>
            <begin position="518"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="722" mass="81360" checksum="FABD997292C55ADD" modified="2016-10-05" version="1">MEIGCENLDFSRLINVRGNVDNITPHKIAVVAFIREYGLLKIEAKTMINCTMAPKYRKDFCILALKLIQCPDMEFKDLETLLTDGRYNLLSVHLENFCVRLKNIHVNGISALMDCVTSTVDKLMIEQSETNPCTITRSSVLGFYLRRIMLHLDKLTFVQVVALYKSFCLYYQKGRPGLMMRSLSKERLNNMESTVGVPSIGSPSLPEESKPQEVFTRMNLIERENSLEECRWSRKQAELFTAQQANLLQINERKALPPKQLQKTIMQIMNDIPEYSDIHFLSFLNCIRMKEFCGAQDSLYNCFDRTVFNICANSNNMNDKNKNFRYAALNRAAMHTQFGHFFGPVEGPSSGSAYFEIFAFASRLALMTIITKGDSINYHHSMTDLTMAGLANTAALWSLYGKTEMASISCQLLLNLNTKCTVGASSVWQWSEACAVAGAGAASVAAWRGESGLAAALLSHLQHRPPAPLRAVAARHRAAAALLAGKWEEAELNIRQLASLDRWESQLLKAEMYFLRGDAMDALETLQDILDYCKTEDDSLHFAPLRLKAMILMSQVQLSYSVSQSTNILLLNEALSWAKKFHLHYLAATVEMHIANVQLHMGCAKNALVLVRKVLPLIMAHGSAYDMARGLLLYTKCRIATSPPSGEARIQVFQSCCEALESVKENFCKIGAQVRLLQTWYIQAQLYNDVGNIAARNQCAWMYRQLETQNPVDLSNMLHIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDZ8</accession>
    <name>A0A194RDZ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDZ8"/>
    <dbReference type="InParanoid" id="A0A194RDZ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF158">
        <property type="entry name" value="ORGANIC ANION TRANSPORTING POLYPEPTIDE 33EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="307"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="398" mass="43389" checksum="5C11D065D3E7BDD8" modified="2016-10-05" version="1">MACSIDSYLEYFAAYKKVWHFLRTYILTLQRFTLFLQGALLIVVLLETNVYLLLRRNAGTGFLRSINEDWVKLGSAGAEFLLGAALGWWGRSWKNLALSGCLGITAASGLIVLAFPYEESQPLAVELCGGGTISAYTSTTGEDAYISARTTFLVLTAILCALTKISVWAHGLTYLDDHEPQNGPYFYAGYGRARLKQTGGTHISPSACLLSCSYDTEFVQARYHIESLRNDPRTSRAINDIFRSLVIIFFVTVFRFRFSSRRSDGVKATTASRVGGVVAVFVSAFLCVVAAMSCGIEGGDIAGIKDVYTQPECSAHCGCNTANYGFSPVCAVDTHTTYFSPCDAGCEQYEDLNGFVLFENCTCGLERAIRGSCSVASCQSTYSFYLLFFALTLAAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF86</accession>
    <name>A0A194RF86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF86"/>
    <dbReference type="FunCoup" id="A0A194RF86">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF86"/>
    <dbReference type="KEGG" id="pmac:106709871"/>
    <dbReference type="InParanoid" id="A0A194RF86"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="650" mass="72561" checksum="0982DC3643D139D3" modified="2016-10-05" version="1">MGVLTVAATAAKSALTIAGISKLTFIPVMLAAMAYFNYDLLDPENRPFNQKYLREEYDFIIVGGGSAGAVLANRLSEVEGWNVLLLEAGGHETDISDVPLLSLYLHKSKLDWKYRTQPQDSACQAMKDKRCSWTKGKVLGGSSVLNTMLYIRGNKRDFDQWEAFGNPGWGYEDVLPYFKKSEDQRNPYLARDKRHHGVGGYLTVQDAPYNTPIGAAFLQAGEEMGYDIIDVNGAQQTGYAWYQFTMRRGTRCSTAKAFLRPVRLRQNLHVSLFSHVTKVLIDKDDKRAYGVQFIKDQLKQIVYAKREIILAAGAIASPQLLMLSGIGPAQHLQEVGIDVIQDSPGVGRNLQDHIAVGGLVFEIDYPISLIMSRLVNINSALRYAVTEDGPLTSSIGLEVVAFINTKYANSSDDWPDMEFMMTSASIPSDGGTQVKRAHSITDEFYDEVFGHLTNKDVFGIFPMMLRPKSRGFIKLRSKNPLEYPIMFHNYLTHPDDVGVLREGVKAAVAVGETKAMKRLGARFNNKPVPNCKHLPLYTDEYWDCMIRQYTMTIYHLSCTAKMGPSTDPMAVVDPTLQVYGVKGLRVIDASIMPAITNGNINAPVIMIAEKGSDLIKETWLPKRRKRNATSKFSQVKKLFLKKNTSCSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF92</accession>
    <name>A0A194RF92_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_08094</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KQ460211">
        <property type="protein sequence ID" value="KPJ16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF92"/>
    <dbReference type="InParanoid" id="A0A194RF92"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265142" description="Fucosyltransferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="176"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ16503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="272" mass="31871" checksum="A3FC755D77230AF4" modified="2016-10-05" version="1">MGFHIWIVCKALSVLGDVTTIIVVNHGKRSLKSWPDDSVYILNWDKHLDTRKIFYGCCTAPKCILTKDKNYFGKDYKYFDAMLFSEKYLESTNRPKTNINMLNIFISIQPKNKKAVCDNYYDDFFNLTFTYRLDSDIVWKDFVFQSFSQEIIAPSLSPAWNTSLNPINQEIKSIIQQKTKSVAYIDCKLENWTRPYLSKLQKHLDAYSLKIYKNNCSNKSDKEVDNGILKNEYMFYIIFEDYFAEDYVTGKILQAYNDNVVPIIFGGANYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFD5</accession>
    <name>A0A194RFD5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08174</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFD5"/>
    <dbReference type="FunCoup" id="A0A194RFD5">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RFD5"/>
    <dbReference type="InParanoid" id="A0A194RFD5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="266"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ16169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="559" mass="61660" checksum="36E7CAC4AB10E183" modified="2016-10-05" version="1">MASRSDYGRVGFIIPVEGAADQYVVGVEHTFLVIHWDGEEGSNVEIIKELGEVDQDAPNTFLNDGKADPRGRLFAGTMCDMGPGVEFIPEKGAFYRLDEKGVTQLCDKITISNGLAWDLQEKAFYYINTVENKIRRYDYDVETGEISNQRYIFDLKKNKMTGGPDGMTIDTEGYLWVALFNGSAVIKVDPKIGTVVDKVPIPAEQVTSVTFGGPNLDILFVTTARFDLGSEQKPPCGATFMVTGLGAKGHPNMSVSVKKVTEPVLIGEGPHWDAEAQALYFVSIDEMTIHKYVPETGLHTKTKLDGRVSFIISVEGTTDHFVVGLERKLVIIKWDGGEGSKVEIIKELAEVDTELPTNRLNDGKVDPKGRLFAGSLGQMTPSGEFEKEKGSLYRLDERGCVKLFDRINVANGLAWDLKEKSFYYIDSMDYKISRYDYDVESGNISNKSYIFDLKKNEVNGGPDGMTIDTDGNLWVAIFYESCVLKVDPRSGNILDKVVIPANQITSVTFGGRNMDTLFVTTASLNLGEEQKPPCGATFMVTGLGVRGHPDAKFKLPANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RFU2</accession>
    <name>A0A194RFU2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RFU2"/>
    <dbReference type="KEGG" id="pmac:106709030"/>
    <dbReference type="InParanoid" id="A0A194RFU2"/>
    <dbReference type="OMA" id="CPHNSCV"/>
    <dbReference type="OrthoDB" id="7473228at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="141" mass="14842" checksum="FF4181D7FA7DBCF5" modified="2016-10-05" version="1">MSAPFYSHDPCVCTGRPCGACYPYTTKPCVASCNNLSACSTCPGGGCSPCPAPVRPCPEPCPPTPILPCLQPCPPCDKPSTCVRPPSRLCDSIAIPCCRPNRYKPCPCYCCTEPAICSPKRCSYPGVPVCNGCCGPCMPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH80</accession>
    <name>A0A194RH80_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multifunctional methyltransferase subunit TRM112-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA methyltransferase 112 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07554</name>
        <name evidence="5" type="ORF">RR48_13655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH80"/>
    <dbReference type="FunCoup" id="A0A194RH80">
        <property type="interactions" value="1487"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH80"/>
    <dbReference type="KEGG" id="pmac:106708802"/>
    <dbReference type="KEGG" id="pmac:106719175"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="14124" checksum="4C3C794F87B80C61" modified="2016-10-05" version="1">MKLITHNMLTSKCLKGVITGYPLAITATVVKVSEVEYNPEFISRIIPKLDWEVLWKAADSIGHNEGLPQTIDPKFEDNEEFLRKAHKVLLEVEVEEGYLTCPESGRQFPITKGIPNMLLTEAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHK6</accession>
    <name>A0A194RHK6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHK6"/>
    <dbReference type="InParanoid" id="A0A194RHK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="130" mass="14451" checksum="142E7A7829A20B21" modified="2016-10-05" version="1">MFPKKYTLLNRRCWLRCVSPVSDRPCDGAAKNDANRGLHLYILARVEPPDSVSERQPKQIIKMFKLLLFVALLAFATAKPLVYSYTAPVAAYTAPVAAAYTAPLAYSAYSAYSPVAYSAYTYGSPYAYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIG7</accession>
    <name>A0A194RIG7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIG7"/>
    <dbReference type="STRING" id="76193.A0A194RIG7"/>
    <dbReference type="InParanoid" id="A0A194RIG7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="166" mass="17972" checksum="01C6BA20AB7665BD" modified="2016-10-05" version="1">MLRKDNVSESRIQELLPLIYNTNPGMFGGYDYGLMQKMSELYKYAPPGMMNSGMMNPVMNPGGGAGGAGGAGAGALGGSSGLQYEPPWLRQQKQQQMRLQQMVQQQQGMGAKYYAGGLGSRDPVAMALQQHRAREIMLGERGRPRGRPPLSRPPPTTDVVNLADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK95</accession>
    <name>A0A194RK95_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK95"/>
    <dbReference type="FunCoup" id="A0A194RK95">
        <property type="interactions" value="1873"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RK95"/>
    <dbReference type="KEGG" id="pmac:106721559"/>
    <dbReference type="InParanoid" id="A0A194RK95"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="275" mass="31454" checksum="35ACEB7184750365" modified="2016-10-05" version="1">MPYANQPSVHITELTDDNVKFVVEDTELSVANSMRRVFIAETPTMAIDWIQLEANSTVLSDEFLAHRIGLIPLISDDVVDKIRYSRDCMCADFCTECSVEFTLDVKCTDDQTRHVTTADLKSSDPRVVPVTSRHRDEDQTDYGEIDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVSFEYDPDNMMRHTLYPKPDEWPKSEHTELEENQFEAEFNWEAKPNKYFYNVESSGALKPENVVLMGIVVLKNKLLNLQVQLAQEAHNDALAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKM3</accession>
    <name>A0A194RKM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING finger protein 145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKM3"/>
    <dbReference type="STRING" id="76193.A0A194RKM3"/>
    <dbReference type="KEGG" id="pmac:106721700"/>
    <dbReference type="InParanoid" id="A0A194RKM3"/>
    <dbReference type="OrthoDB" id="4752984at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="44819" checksum="E646C2979EFEDB97" modified="2016-10-05" version="1">MGMISRVRGRIRSDSFSKIHTMKSEDKIANIVWLLSVVLLLPYWAPRGLFVALGGAWLMAAYTCLVVPVLISANYRYPARWYPAVAKLAQEVARRLRAPGACLLGMLRTAYAPLERAERLFLQMNNLSTMICQLLVFTACDKLFVSQGRLTCLYSLMFYNVITYSVSYVREICTKEDWSPYVNVTRHSRVKHLAMSATKIVLEWTKAVTFIVTITFILLTLGLEQGLEHFRPTALYTAITGTYYLLTERTFLELWPIALSAMKLERLEGMEALYCGVWARGVTTALALPLVPALAWCERWRLSILVLYVCVFMHGRHRLGEALVKMNEACDSLAKFRRATPEELSTLEDVCAVCLGSMKSARVTPCAHYFHADCLRRCLATSDRCPICVRPYVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKP2</accession>
    <name>A0A194RKP2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKP2"/>
    <dbReference type="InParanoid" id="A0A194RKP2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="281" mass="32468" checksum="AA1C5240C663DED4" modified="2016-10-05" version="1">MHSRNFMIKESSSTKENSLKDPGGTKVTSKRFKLRISIIGAEKLFAPMRKKDQNTTEFPLKLRRFFKKAKKKILTKNVFKSKNVDSNKNVQDKSIIKNNEKMKCRTIATGFPVKINSIDFGCQYSLNSNCSMEIISHMLTRSISQMSSVDSMFDVEWRRRHQAKQPNTIHVFLYNVIRRFKQSKTKLTNKTKKNHILVLHVPERFSHTSTDTISSIYSRIRGKETPLNIQAQSQNSETGCTGHRPVNKICGPGEIYLKNDDSEKRELKINLLSSYHRLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMA2</accession>
    <name>A0A194RMA2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_10601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMA2"/>
    <dbReference type="STRING" id="76193.A0A194RMA2"/>
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    <sequence length="460" mass="50540" checksum="AB74DA952DFC42B0" modified="2016-10-05" version="1">MSDKRYILGMDIGTTSVKVCVYDPKTREIVAKQSKDTAANIPSDQGIEGNKQDVPKIVSAVHYCVSRLPRDVLRHVTRIGVCGQMHGVVLWNNGAWEKVEKEGVVMRYEATREKMSALYTWQDTRCKPEFLESLPKPDSHLNCCSGYGCATLLWMLHNKPEKLKSFTYSATVQDFVVAMLCDLKNPVMSDQNAASWGYFNTEKNEWNHDILNSINFPTNLLPKVVKSGVIAGVLSESWNGIPEGTPVGAALGDLQCSIIATLENREDAVLNISTSAQLAFVVNSIQDVGCKTVEHLPYFNNTYLLVAASLNGGNVLATFVKMLQQWMLEFGFPIPQSKVWEKLIALGLEAPTTSAMKICPHLLGERHAPASKAAVDNIDLSNIQLGCVFKSLCDSIIDNLHIMMPKRILQNANIKRIVGNGSGLSRNAVLQRAVEHFYSLPLEFTSGGDAAKGAAIAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNE0</accession>
    <name>A0A194RNE0_PAPMA</name>
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        <submittedName>
            <fullName evidence="4">BCL-6 corepressor</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">RR48_12538</name>
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    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the BCOR family.</text>
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        </source>
    </evidence>
    <sequence length="2060" mass="230204" checksum="8C173D906B6ED222" modified="2016-10-05" version="1">MDYGFNNVFEGTRQYFMGLPKQAQAEGSGQPVWPTSAPPPEEGAPAQSGAPAPSSRPPSAAAAPPSTPGPTVIAPPPRPPRPPSEPIEPEPHIIHKATVMREAAEKRREMPDPEDEEEPMGALSPPSHIIRKPTPRTLPSPAPAPAAPCPSPARPPSAAPLARPTSSEPQIDQHGQYRSSIQRVQTPTARPPDQYTPSRPPDPYSSSRPPESFARFPYEPPVHDGGRNSQGPPIASPQPVPARHSPTTYARLSSVMPQHAVARLRESAVQSPPSSRYSMQPAQAPPPHNDRVPPIHHPQAPPPTQRVTVEGRSAQAYLPPVHRRESSLTRSSHYDRHPSIPARKYDPQQAYPGYRPSLTTQNHRVEALPQYKHSGSEGLNTHFAARPSERAQTQPMGNEPTRIQPRIDFHGKSRSVDTRPSYHYPSPSTSHVRYAPSAPVPTIHHNASLQPRTSYRGAAVAKTNYNYSPVNQVQSSPSRSSIKAGYSNQQTRMTVSVTSIVNELNQTKKRESPLDLSVKTVKNSADSSTTQDDAIDSASYESKSLPLQPRPTSSSRQVPSLPGYIVSHKVDFAPDFNQYRDRNTNHNCATPPQPVRYNGTYETARPAAERMSYPVESRHHHYADRSKYNGPVQPRTDYVPRIDLTRSVADERQTERVREDPQIVMEERKRPAGPIVSNIPEKLVRYETWTSDSRIERMSQSAREQHELMSRPVYSYSSHKRFEAYQNDQKRVTASNMYRDHHPHTTQRHSRTVYPEKLNRDISDYQAHYHDRVPSSSRHVIQKIPSHKDVHPQHLDVQNGPANKSVLSILRNSLETKQTGYVETTRPIRQISDVIVLDDVDDSVIEITDLTKDGEQEPTNKNNPKMQSNQNNPILGHHIQMPKAVDSFARDSVYQKCDNSQPKSKSPENDVAARIRTKAELKVMPPSQDSNQKQDKSSDSDSEKVKILPKSQKQHLFNQIREDNLRLESVIKNEKPTDEFISEVKAEPMNIDEIEKDAVASIKSENILGSLEPENLIPVDQSSPEDLDWASACDSFMEQLKTGCLKKKNNRKRNDTLDHETEVKIPKVVKLGTEENSSDKTEIISTTVIEIKQEPIDEDEKIETETSIVTEHEELLTEIPNEIENHESVENKDKKDDAKTQKSKTQGKNKTKLEKKDALPTSSATPVKNDSFPTKTVIKEEMDSTDEDEPLIKSKIMKEKVQRELKYQMLKDLSEKSVYVKLECCDEQVSVNSRKSTETISKDKVEKPAKGKTNRLISKTKGKTSIAESKNEKRNDISSSDSDDDVSVASRLRVRKVNKSDDNKNEIANKTPTKSSPSKKLDTSSASNSSTPIRKPGFGDGSNFHPGWEDELYKYKRSLRMPTRLIAIPRGRSGEPFAKGSANLFTRGSTSLPDLDPVPLSPAPSSSQSAATDDLYGRRPDKMNLDSDLDSNSSCSAPNRLQYDSEASTSTVFSACKVKKKSSSIVDVLIQKYGKKEETKKKSKDKDEKNAKIMQKNSNVSELLPTPGLGLVKNGSKGSLSAKKEKLMEDIFYLGAFRKETVTAFRNAFIKNTDGLLGTTEEFTPMVLQTRTRTESRVLKQRATIKEVFGDERPASAPPTSCRQEEVAEPQQEKIVEVKKESEPKPKFKPRKIAKEKMKRRSSSIRDGLRSTKSLKRNDAKGRLLRLKKRNNLMKTFNAKRKESTSNKVKKEKSPTPENKDNAKEENSTPETAETNTKRRFKRLFGRRKFSSGFDYIRKKKKMIRKDDNNCNKIRRPAPKPSPESVHDIQKEIKSWFINKSIGETHLHRAARLGFTDCVAYCLEKMEADPSAKDNAGFTPLHVAAARGHVRIARLLLQYGANVSAAAQGGIRPLHEASENCHVEVIRLLLSYGADPLLGTYAGQTPGELAEGGAALLLRLHVADVQGQAQEPWRFPPPTEPIDCEELGCDPLQSPPPATPPPPADTTMEIQTTDAPLPPFYSLRSATGQPVDGLWCLLQDIANVLQIKSKDSLLKQIHCGSGSPKELLREIRTQEFLERAQCHQLLCAGEKVNVRASKVALIRVTDKLRQLLKIETVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNT1</accession>
    <name>A0A194RNT1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_07164</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNT1"/>
    <dbReference type="STRING" id="76193.A0A194RNT1"/>
    <dbReference type="InParanoid" id="A0A194RNT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ17676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="505" mass="59087" checksum="6741B87D198C1EAA" modified="2016-10-05" version="1">MYTHKRLHRYFEEKGLKYNPGLPIFGNVIRSTFIRKHFVEDIDKVYREFPNEKYVGYIEATSPIVLIRDPEIIKRITVKDFDHFVNHKEFFPSEIEPLFGSSLLLMKGDKWRDMRTTLSPAFTGSKMRHMLPFMVEISNNIVNYLKDHTNKDIDVCDVMRRYTNDVIASTAFGIQVNSLQDKDNDFYKTGQSLFKMSPLQRFKFFFVNQFPAFSKLLNLKIFDDKYTTFFENIVTNTMEHRYKNNIERPDMIQLLMQAYNGSLKAEDVDSNDDVIIEADRLNPQSSDKQWTQRELVSQVFLFFLAGFEVSANALTMCIHELAINPKIQDRLYEEIKSFKEKHDRLTYDNINDLKFLDCVINESLRRWAPALILDRVCTKAYELPPPHEGGKPCKLNPGDVVYNVVNSIHLDPQHYPDPEVFDPDRFSDERKHEIKPFTFMPFGIGPRLCIGSRFALLELKVLMYDIVLNFNILKCEKTSDPITLDPSDFNLKAAGGTWVHLERRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ17</accession>
    <name>A0A194RQ17_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_11969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ17"/>
    <dbReference type="FunCoup" id="A0A194RQ17">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQ17"/>
    <dbReference type="KEGG" id="pmac:106721527"/>
    <dbReference type="InParanoid" id="A0A194RQ17"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000003">
        <property type="entry name" value="39S ribosomal protein L11, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="11">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ18121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="196" mass="22006" checksum="ACC942FC1A471BE2" modified="2016-10-05" version="1">MSKSVARLKSMKKVADKIDHSSKLRTNVPAGMAAAGPPLGPMLGQRNINIAAFCKDFNERTANIKPGIPLPTRVKVNSDRSYQLTIHQPPASYFIKQAAGVNRGAMHPVNEICGKITLKHIYEIAKIKSQDPPLEWRPLQEICTMLIATARTCGIEVVRDLDAKEYGEFLQERKQIIEEQKKMLQEKREAKMLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQC7</accession>
    <name>A0A194RQC7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQC7"/>
    <dbReference type="InParanoid" id="A0A194RQC7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="8228" checksum="05FCF801AB5479DD" modified="2016-10-05" version="1">MKEECKLCSMSGWIAGGQGSTDFSIRSLMAPRGQGEPRHDALLLSAYLLKLGDYPLYTLHDHYGAGEYRARSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR70</accession>
    <name>A0A194RR70_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent asparagine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_07404</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR70"/>
    <dbReference type="FunCoup" id="A0A194RR70">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RR70"/>
    <dbReference type="KEGG" id="pmac:106713638"/>
    <dbReference type="InParanoid" id="A0A194RR70"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="15">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="552" mass="62671" checksum="938C7E64F395BF53" modified="2016-10-05" version="1">MCGIWGTFGMDGGLTPTCIKCFAAIVHRGPDAWRLEQDSREPQAVLGFQRLAIVDGLHGMQPMRLHCFPRLTLICNGEIYNCKRLRDQYNFPYETNCDVEAIIHTYKKFGIADTVNKLDGVFSFCLIDGEARKVYIARDPYGVRPLFKLHDNEKGLMAICSEAKGLMGLKQKASESSSLGQFPPGHFEVWSLLDDGKVKLDYNERYFTPGTPPRFVPYVSTEELAKLNSLYEKTAFLLEAACRKRLMSDRRIGCLLSGGLDSSLITALVVKLAKEHKLPYKIQTFAIGMGDSPDLAAARTVADYLGTEHHEVRFDENDVRQSLDNVIYHLETFDITTIRASLPMYILSKYIKENTDTTVVFSGEGADEVAQGYIYFRDAPTPVAAHEESIRLLSDIYLYDGLRADRTTSAFSLELRVPFLDIQFTHHYLNIEPKLRQPQNGVEKHLLRSSFAKSGLLPDSILWRHKEAFSDGVASVKKSLFTTISEIIAERLPEDDQQFKGLQPTSTESKYYRYVFEKSFSGQHNFTPYYWMPKWVQVSDPSARFIKHYAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RS46</accession>
    <name>A0A194RS46_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RS46"/>
    <dbReference type="InParanoid" id="A0A194RS46"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="12574" checksum="9B61479CC51CA7FB" modified="2016-10-05" version="1">MNSPCFASAPYIFHPVSESSATESDDSTDSGQEKIVGGTRTKYNDPKHRTINKVSKKILKAIERLTCNLKKKTKKYKALSENVKVDTPSNKSVATKPPLKSPSAPVAPCSLPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RU42</accession>
    <name>A0A194RU42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RU42"/>
    <dbReference type="InParanoid" id="A0A194RU42"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12766" checksum="37E6DF163E75A75A" modified="2016-10-05" version="1">MATKSRLINFLSEERYSMLSARFAAFHEAMNEPTRPVVRVYDPLGSRHLCELQLVREVSAELQQKKQEDMKKAVSISHTLTSCAYAIYIKNFLHRMVKEIAFLDKSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAV6</accession>
    <name>A0A0N0PAV6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CCR4-NOT transcription complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_04052</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAV6"/>
    <dbReference type="FunCoup" id="A0A0N0PAV6">
        <property type="interactions" value="1282"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAV6"/>
    <dbReference type="InParanoid" id="A0A0N0PAV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="503"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ07032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69013" checksum="DEECD4AA4F949B18" modified="2015-12-09" version="1">MAASRKLQGEIDRCLKKVTEGVETFEDIWKKVHNATNSNQKEKYEADLKKEIKKLQRLRDQIKSWIASGEIKDKSTLLDNRKLIETQMERFKVVERETKTKAYSKEGLGAAQKLDPAQKEREEMSSWLSSSIDALNLHVDLFESEVESLLVGKKKRLDKEKQDRMEELKVKLEKHRFHIKKLETLLRMLDNMSVEVDQIKRIKDDVEYYIVTSFDSNYDETDCIYDDINGLDEIELSGVGLPSSATTDSNNSNDSPGSPTSILSGTSPITSPALDALNHSTDSIDVDKKKKAEELVAKPVKPLPLRAVNSCAVSNSATNLTSLLNNSAASTNSINTTGASGTSTPIKLPLAPSPPHLTHLHQRNNTEIVENGPVSIAPLHNAVIHQTPLAQPLPFHTNAALGVTKLPGCKRIMSGGVAVVVFDQTGLNSSHPDVKKRVCDAFKREFDERRGRGGGHAGAPRAFAPTRPRAGTCACAGTCVRARARAHAQRAYPTHQCARTRAASPSYRRQVLLPHSDSVEFFQRLSTETLFFVFYYMEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKVINEEYEQGTYIYFDYEKWGQRKKEGFTFEYKYLEDRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB33</accession>
    <name>A0A0N0PB33_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB33"/>
    <dbReference type="STRING" id="76193.A0A0N0PB33"/>
    <dbReference type="InParanoid" id="A0A0N0PB33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="28689" checksum="A6C4F3CBB794865C" modified="2015-12-09" version="1">MCNVCEQTEAECGATACGCGSSARAPASRARALAHTGSAALSRDIFKSMFRCRKINALRAVRNLIEFRRSERGRCAASPRSRPQWGLRCAGLCGAGGRCVRAGGGVCACPAGRGGAHCQRYVGHDSACAALSCPPRALCAWRPDDDPLGPGEAFCACEGEGCEAGGAGAGAGGGAWLGGALALLTLLTLFLAALYLVHRRRRGAFLHARLADNVEINNPMYLAGEDEPELRPAHDANGGNHFANPVYESIYSPQDAHPTEERANLLQEGSPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCQ0</accession>
    <name>A0A0N0PCQ0_PAPMA</name>
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        <submittedName>
            <fullName evidence="7">Putative inorganic phosphate cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460470">
        <property type="protein sequence ID" value="KPJ14578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCQ0"/>
    <dbReference type="STRING" id="76193.A0A0N0PCQ0"/>
    <dbReference type="InParanoid" id="A0A0N0PCQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.540:FF:000001">
        <property type="entry name" value="Blast:Putative inorganic phosphate cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="20472" checksum="636578778354BCF5" modified="2015-12-09" version="1">MSEMVFVWHKVTEVGCCRAHTDLLHSTGRALFSYGFGVRHLQSVCMCLCMISLFIARGSMAVAVLAMTDHSRINSTDITIYDWDKNIQGLILSSFFWGYTLMQIPAGLLAKRYGGKPVLLVALLANGVICGLLPVLSYVGGWPVVCACRVLMGLTQACLFPASHTLLGRWLPAQERTTLTGIIYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCY9</accession>
    <name>A0A0N0PCY9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syntaxin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460501">
        <property type="protein sequence ID" value="KPJ14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCY9"/>
    <dbReference type="FunCoup" id="A0A0N0PCY9">
        <property type="interactions" value="1548"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PCY9"/>
    <dbReference type="InParanoid" id="A0A0N0PCY9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STX17-like N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="239" mass="26201" checksum="5961ECFBF3BA91F3" modified="2015-12-09" version="1">MEEPGKLSLKRVELSLTKFNEVAIPHHLDLLRQHKTNIIKYGESGDTRRLRAEQTHARRVAGQLRALLAEMDALRAQVRQEDRARFDAMTQRTRDLTLRAIVDYLGVIERSCRGLVGAGREGARRESSPVTIRRMEAEAAEAEAEAGSARSTESVGVVAHAPAQLQLHHDEQEAALREREAVLRGWGELQAEVQARSTGGCRRGMEGAQSQPRAPPPAPAPAPAPAPAPAPAPDHEKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD68</accession>
    <name>A0A0N0PD68_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_05359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD68"/>
    <dbReference type="FunCoup" id="A0A0N0PD68">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PD68"/>
    <dbReference type="InParanoid" id="A0A0N0PD68"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000018">
        <property type="entry name" value="Spatzle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF13">
        <property type="entry name" value="PROTEIN SPAETZLE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="530" mass="58324" checksum="CB10BD6779A0D545" modified="2015-12-09" version="1">MAVANFSVPTIGAATPAVIGTTSSPLHVDLDDLLYSPEDYQQEYAPQYPGNEPFSPPQSQAQPKRSKLRKRAGTAYLPPSPQQYAQYQRQDIPVNPFTGQMQAQMYQGNARLDIHGANQRVNAQYDNTGQYVHDPTGDYDYEQRRDKDGTPRQPYNPGYADSPYPPATTPVQSSSRRLDGVPNQPVNKFFGNNPVTSPTQRPRTDTGTKSGNSGGSANSAGGRSNANAPPDQPRGFTKVETGGSGGKTQLHAVLDYDDDEYYDDDSGSDSGQPAVTPLQGPILLRNGSVPVVPLTSYPTVNNGSFYQIPQLYGSGSPYNMDLLISHRNIILWTALSLALGYELQGQIIRGVPCVKRNFQLYCPTAGNTYPIDKIEMFIDENKALIKRMYGSFSIPGGGRVRRAPGVPDMHSGDSYFRHVRQASKSTLPDPQVNNTGRIDACQSKTEIITPYWALNSAKKVRAIVNTMHFEQAIHQEVCSKKSTARCSGDCSCEQKYKWHRLLAYDPSNDCAGIFMDWFLFPSCCVCQCDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDK6</accession>
    <name>A0A0N0PDK6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A0N0PDK6">
        <property type="interactions" value="1433"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDK6"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000269">
        <property type="entry name" value="Single-stranded DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="14496" checksum="91996A0D5FAE3F71" modified="2015-12-09" version="1">MTTVRFDTQKTEKTINQVTLLGRAGADPQKRGTEEHPVINFPLATHYSYKYESGDILQRTDWHRISIFKPGLRDTVYKYLKKGQRVYVTGKLSYGEVKLDDGQVRSASTVIADDVIFFQNQQHTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE31</accession>
    <name>A0A0N0PE31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein Nkx-2.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE31"/>
    <dbReference type="STRING" id="76193.A0A0N0PE31"/>
    <dbReference type="InParanoid" id="A0A0N0PE31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="398" mass="47336" checksum="D198D49E86FD3E0A" modified="2015-12-09" version="1">MESYEQVYNNNNLKNNYNEMKNDFYNYQDTNSKSQHKDETNYRLKMDDNSNLTTPFSVKDILNINQNDYERNDMWKNDRDRRVNDFEPVYHQNQYCPDYVSQLYHNIPVHSNMEYWNPEVYDHKVDEYYNYNQYYHNFYQTNEYQDVPTISQTGESSIKLDSVEREPPSVMPPLGPVPYKSQQPVVQNFNTYPKGDVMENFNSISRKTTKAVVTNGKTDKKDKNTKRKPRILFSQAQVHALEIRFRAQKYLTAPEREQLAKTLNLSPTQVKIWFQNRRYKSKRITTPEVSTSTDAKPSKSSTGRKLYKPETEFNQIKMEPYEPTQTENEPVCDTNESVPIYFDDSLNYDNNVPDKYYRHLNMEQNVGTSSDIYTNNIGETNYTEQNDIKKFYTMNYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7C7</accession>
    <name>A0A0N1I7C7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_03827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461003">
        <property type="protein sequence ID" value="KPJ10039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7C7"/>
    <dbReference type="KEGG" id="pmac:106716213"/>
    <dbReference type="InParanoid" id="A0A0N1I7C7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18756" checksum="219052DC21129FC4" modified="2015-12-09" version="1">MSCEIIIRKARKEDAVQRAELIQMGLLSHQWDAFLYFLFQEVVGTLSVSEYREGGGLALGEDAGWLHALAVHAQYVPRAAQRTAHTAVLSARCCRWRRRGVGRALAGAARRAAAERGLRALEALTSDLQRAARAMLHAQGWQCRGTYDRRLVGAALTLQLARLGLDLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IA31</accession>
    <name>A0A0N1IA31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U4/U6 small nuclear ribonucleoprotein Prp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IA31"/>
    <dbReference type="STRING" id="76193.A0A0N1IA31"/>
    <dbReference type="InParanoid" id="A0A0N1IA31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000443">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="144" mass="16641" checksum="C86FFEB7338529D1" modified="2015-12-09" version="1">MSELDAVLCSLRDIWDLYLVLHGILLDIASPLPPLTIRHIHTYIQKYIHYAKIWDIRKRAPIYTIPAHTHLVSDVRYQRSHGHYLATSSYDGSGKLWSDPAWHPLRTLSGHDNKVMSVDISLDNKYIATCSYDRTFKLWAPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBC2</accession>
    <name>A0A0N1IBC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formin-like protein CG32138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBC2"/>
    <dbReference type="STRING" id="76193.A0A0N1IBC2"/>
    <dbReference type="InParanoid" id="A0A0N1IBC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="12140" checksum="6E573427FB005EBB" modified="2015-12-09" version="1">MDLPPDKAKLLRNYDLEKKWEIICDQDMVQAKDSPAHYLNKLRTYLDPKASRSHRKRKMVGDSTSTQVLRDLEISLRTNHIEWVREFLNEQNQGLDVLIDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBJ6</accession>
    <name>A0A0N1IBJ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461184">
        <property type="protein sequence ID" value="KPJ07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBJ6"/>
    <dbReference type="FunCoup" id="A0A0N1IBJ6">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IBJ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="281"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="689" mass="79100" checksum="9C7B20C3B6175E5D" modified="2015-12-09" version="1">MNYKQFSHSPDVSLSDENTSMMYGLGKASLKHLCLQPALQEVLNLEAQHIIQLHLFLIQHSDPHQTTKQCITCTEKLIEAIILQLNESEYDRMPAIFDLEPYHPCLRREDGVYCLLRVDLHADEDNELMQLIRGYSEHTVKHFNYTYLQRGVCVSTTCRDFMSDKTEVISRVEDLGGILERCLNESLFKQHGLQAKLSTVYNCDKQNDEITYDTLDWIVAVCFLIILAINIIGSCYDYFCLSKMDKNNKENRFLSSFSVFRNWKWLTEYSAPEPRMEKLKGFHCVKCILMFFIMFDHCAWMNVTFTNYPLDYERYYDTWGYQLVNGGMMLVQMFFVLSAFTLAYNLLLKSEKMPLTWAIYPKIILLRIWRLSPAYAVVLAFTASWLRHAGGGGDPLWQLAGGSVAGACQRYAWTHLLYFNNYVEDNKACALHTWYLAADFQLFVLGLAVMVGTRGRTRHVALFVLFLIGLLLPAWQVWLQDLDAIVLKKPEFYRSFHNSTFRKMHISGHANIVCCVFGLSTALLVYRLQKNKVDLSRNKILKHMCWFVVPGVMVLLASCAVFYTAERASLLTRMTVAALHRVVMATISSFVIVALVMRINKPISRLLEWGGWAVPGRLSYCVYLVHLNMVHVLLARRTHLSQVSMYNLALNFVGVYGWSHVVALVLHLLVEAPTSRLVHAATAAHLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID96</accession>
    <name>A0A0N1ID96_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surfeit locus protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_00337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01067169">
        <property type="protein sequence ID" value="KPJ21697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID96"/>
    <dbReference type="STRING" id="76193.A0A0N1ID96"/>
    <dbReference type="InParanoid" id="A0A0N1ID96"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873874" evidence="6">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ21697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="70" mass="7820" checksum="1FCC740934FFADD3" modified="2015-12-09" version="1">MQFLLRNLALIGALLLVLAEARAEGRSLFAGVPSLGENKPKTYLQLAGRILLAFMFITLLRFEVSFLQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEB7</accession>
    <name>A0A0N1IEB7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_01431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="KQ460555">
        <property type="protein sequence ID" value="KPJ14019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEB7"/>
    <dbReference type="FunCoup" id="A0A0N1IEB7">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IEB7"/>
    <dbReference type="KEGG" id="pmac:106711937"/>
    <dbReference type="InParanoid" id="A0A0N1IEB7"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="14">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ14019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="351" mass="40504" checksum="A69AC691C18F70F9" modified="2015-12-09" version="1">MDQFEPTEHQHVRYNPLKDEWILVSPHRCKRPWSGQTEQATEEPPPDMNNPLRAGAVRSNGQRNPNYTSTYVFPNDFPALLPKVPEPPPPEHPLFQAGPAKGTCRVMCFHPDSTMTLPLMSLEEILAVIEEWISQVTELGRRYTWVQVFENKGAVMGCSNPHPHCQIWASIFLPNEPRVKDRCQLEYYKKYGKSMLVEYVEKELEQKERIVIQNSEWIALVPYWAAWPYETMVLPLKNSPQRMTDLNTEQKRGLADIMKQLTTKYDNLFQCNFPYSMGWHGAPTGPSSTPGDSPHWLLHALYLPPLLRSASVKKFMVGYEMLAQPQRDLTPEQAAAKLRECSNLHYKNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGR1</accession>
    <name>A0A0N1IGR1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460735">
        <property type="protein sequence ID" value="KPJ12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGR1"/>
    <dbReference type="STRING" id="76193.A0A0N1IGR1"/>
    <dbReference type="InParanoid" id="A0A0N1IGR1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="132"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="35698" checksum="1843CB12E6475EAE" modified="2015-12-09" version="1">MATCAMRTGWLASVGTSKYSSICPKILQSALVYPNVLNSTTILTQKSNETDDEEPQAIARYNLMPPRFRLHRDIIFSLEDLFVLPIGLDVGILGVTAYFITRLKKADPSNVAQIFGPDPWSKESELHPEKVVKCIAHRGASLDAPENTMQAFKYCVDRDCNFVELDVRSSRDGHLVLLHDEGLGRLTGAEINNVHVMDWDEIKNIDIGANHPNRQQFKEVHLCLLDDALKYLLANDVRVIIDVKGEDKEVVDGIVKAFSDQPNLHQRAVVTSFNPFVLYRVLLEVARRALRRLVGQPAAGEAVLARSSARPLPRQHAAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II91</accession>
    <name>A0A0N1II91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spectrin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01050207">
        <property type="protein sequence ID" value="KPJ21479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II91"/>
    <dbReference type="STRING" id="76193.A0A0N1II91"/>
    <dbReference type="InParanoid" id="A0A0N1II91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000032">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ21479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="114" mass="13224" checksum="852EC0394B6BD660" modified="2015-12-09" version="1">MVEEGQPDPEFEAILNVVDPNRDGQVSLQEYMAFMISKETENVHSSEEIENAFRAITAHQDRAYVTKDELYANLTKEMADYCVARMKPYVEPKTERPIPNALDYIDFTRTLFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJX0</accession>
    <name>A0A0N1IJX0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052442">
        <property type="protein sequence ID" value="KPJ21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJX0"/>
    <dbReference type="STRING" id="76193.A0A0N1IJX0"/>
    <dbReference type="InParanoid" id="A0A0N1IJX0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="7973" checksum="93FFEEF846A1E40C" modified="2015-12-09" version="1">METEAIDALQSGKDEEEGIKITSTGPVKAALEDEMQVDEDESTLLPKKVTIRSKLEKGDKKKGKKKTIPKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJX2</accession>
    <name>A0A0N1IJX2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052778">
        <property type="protein sequence ID" value="KPJ21547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJX2"/>
    <dbReference type="InParanoid" id="A0A0N1IJX2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8394" checksum="743BE63E445D0573" modified="2015-12-09" version="1" fragment="single">YIFVPFAVETLRPWGAEARQLFKEISVRLIDVSGDSRAGAHFGQRLSLVIQRGNAASLLGTLPCQRSDLGSIFYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INB6</accession>
    <name>A0A0N1INB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INB6"/>
    <dbReference type="FunCoup" id="A0A0N1INB6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106719043"/>
    <dbReference type="InParanoid" id="A0A0N1INB6"/>
    <dbReference type="OrthoDB" id="6261058at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="9562" checksum="797AA29F095B0193" modified="2015-12-09" version="1">MAQGKLKVKSKLPSGVKAKKNKGKAVTKRSNAPVRSKNNAVEKNKMKAKVTKMVNAVAEQQLRALATDTPKLSDAQQRVAAAPTAPVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INI9</accession>
    <name>A0A0N1INI9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box pox-neuro protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461053">
        <property type="protein sequence ID" value="KPJ09931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INI9"/>
    <dbReference type="FunCoup" id="A0A0N1INI9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1INI9"/>
    <dbReference type="InParanoid" id="A0A0N1INI9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF43">
        <property type="entry name" value="PAIRED BOX POX-NEURO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="42117" checksum="2AD9ECFFF725F5DD" modified="2015-12-09" version="1">MAHCEAGSGVGQAGVNQLGGVFVNGRPLPDVVRKKIVELAILGVRPCDISRQLLVSHGCVSKILTRFYETGSIRPGSIGGSKTKQVATPTVVKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGLAWSDEEPRSGHEPYPQPELSPNVMDYMALKTSLTPTSLPPQQTTPYFAHSAVRIHPSQPTDPAQIYDRRLATSWLLANQVQAQGLLKPYPISPWQRIMMPYHTDSKNFTPYLSLHSDLLNRINSDDVKSENSEHISVEASDDSTDRPDDEQDHKTKEKEKKKNPYSIEELLKKPDKISNPYPIAFQNIPRQPSGSMVEYNNQEKNSSDRSSPASYCSVQSGVSNDCFNETVSSEIKAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INS6</accession>
    <name>A0A0N1INS6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INS6"/>
    <dbReference type="STRING" id="76193.A0A0N1INS6"/>
    <dbReference type="InParanoid" id="A0A0N1INS6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27883" checksum="1DE0E3CDA1136092" modified="2015-12-09" version="1">MYLERLAGTTKNLDKVPLILAGDFNINFSNEKSRPLLQFLEEEFDLRNNNNPAESTTKYNTTIDASCRFMCSRVSNGKRVPPQVTGTMNGHSTSLSVEPRKRLTPIADINTNGSHTPYKVQKALVENTMVPCINAKPYQYTELLMTLPDLASHFFPRVPLATCRSMLEALGLTLYRPNSLGITSFLSEFQSAAAGENGLALVQIRDVMQHMLQIKYMLRSGMAMEEHTQQQPPRPAHAHPPHAKRARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP08</accession>
    <name>A0A0N1IP08_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA synthetase short-chain family member 3, mitochondrial</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acetate--CoA ligase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46172"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46173"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ460869">
        <property type="protein sequence ID" value="KPJ11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP08"/>
    <dbReference type="FunCoup" id="A0A0N1IP08">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP08"/>
    <dbReference type="KEGG" id="pmac:106714329"/>
    <dbReference type="InParanoid" id="A0A0N1IP08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="120"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="676" mass="74730" checksum="313EF3C2EEB3333E" modified="2015-12-09" version="1">MYQADDGITSLQKNKFESSISELKKKTFLTAADIESYGDSGVTKEYALAHRRSLEDPEGFWAEVGHELVWTKPWDRVLDNTNPPFTKWLAGKLRSLGVERGSRVLIYMPLIPEAVVAMLRITYAELLDQVSRLAGKLRSLGVERGSRVLIYMPLIPEAVVAMLATIRIGAIHSVVFGGFAARELRTRIEHAEPTVIIAASCGVEPNKIVRYKDILDEALCQSSHQPRACVVYQRRRVLECSLEPGRDVCWESAMSSEPAPCVSLEANEPLYILYTSGTTDDPKGIQRPIGHAATLCWTMHAVYGLSKGVCWTASDLGWVVGHSYICYGPLLAGLTSVLYEGKPDRTPDPGQYFRIIEQHRVNALFTIPTAFRVLKRVDPNAKYSRRYCSKTLKTIFIAGEHCDQDTRMWAERVLNVPVLNHWWQTETGSPITAACLGYGVQCVPPHSAGYPVPGYDVRALREDGTECNRGEVGRLALKLPLPPGFASTLWQADDRFKKVYFETYPGYYDTQDAGWVSAEGAVWVVARADDVINVAGHRLSTAALEDVVLKHARVADAVVVGAPDPTKGDVPLCLYVMRPPQDDEEMVEESVVTQELIALVRHLIGPIAAFRKAVAVPALPRTRSGKALRGAIAKLARSQLVRLPSTIEDASVFKEIKTALQKFGYAIDAPDPEIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ44</accession>
    <name>A0A0N1IQ44_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459795">
        <property type="protein sequence ID" value="KPJ19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ44"/>
    <dbReference type="FunCoup" id="A0A0N1IQ44">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQ44"/>
    <dbReference type="InParanoid" id="A0A0N1IQ44"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="304" mass="33830" checksum="494A463371917826" modified="2015-12-09" version="1">MTELELSNLVTIKCKQQVVRAVRFNIDGSYCLTCGADKKIKLWNPHRQLLLKTYGGHANEVLDAAGSCDSSHIVSCSADKSVILWDVATGQPVRRYRGHASTVTCVKFNEESTMAVSGSVDNTVAFWDVVSRRQEPVQVLKDAKDTITSIQVTNNEILTCSIDCHVRLYDIRVGKMISDYIGKMVTFGSITHDGQCYVLSCADSTIMLFDKDSGELLNTFSGHESRDYLLENAINEKDSLIISGSASGEILYYDLISSKCVKKLIHNLNKPVISISHHPTDSYMLSASEDEIKLWGTRLMEMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQT6</accession>
    <name>A0A0N1IQT6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01037413">
        <property type="protein sequence ID" value="KPJ21316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQT6"/>
    <dbReference type="InParanoid" id="A0A0N1IQT6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11227" checksum="4A419BF7613F6095" modified="2015-12-09" version="1">MLNILIPQALKECTKTTCATYNCKSSFKKAFKANSKKACIAEFWREEDSKIGNKRNTSAVIYVNHPDTPPRITRTFVDLNLGCEDEEVTFQYFITLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFC8</accession>
    <name>A0A0N1PFC8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 97</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_03224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461193">
        <property type="protein sequence ID" value="KPJ06993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFC8"/>
    <dbReference type="STRING" id="76193.A0A0N1PFC8"/>
    <dbReference type="KEGG" id="pmac:106719361"/>
    <dbReference type="InParanoid" id="A0A0N1PFC8"/>
    <dbReference type="OrthoDB" id="515313at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038791">
        <property type="entry name" value="Cfap97/Hemingway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28709" checksum="443E8444950E2503" modified="2015-12-09" version="1">MSRSEIKVGARTESSGYIDMDFSSGDSNKMKPKQFYREENNNEVDELSKDLTEMGCIVDAVKRPPNICVETCVYEDSDSGNDKSEVETKDNEDDVYSDEFEEDRSEIEEVVKKTKEQSKSEHNINKETPSTQPLVKLTKSLSNSSTNKPQSLSGQSTNYGSISIPATRRVNMSFTNERLREIERHNHILLNKILSARNSRKSSIPPREQPARKPVPPAAVQRKIQQKKIDHDNMILLKKIQRAKSSAYSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFZ4</accession>
    <name>A0A0N1PFZ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFZ4"/>
    <dbReference type="InParanoid" id="A0A0N1PFZ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7613" checksum="F03FA06C66818102" modified="2015-12-09" version="1">MAVICTKVVKRHFCQALQKSTKSPIFYGRERICSRVLTKPLFSNTYKHNIITFSNSAINKHFAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHG6</accession>
    <name>A0A0N1PHG6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_05951</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHG6"/>
    <dbReference type="FunCoup" id="A0A0N1PHG6">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHG6"/>
    <dbReference type="InParanoid" id="A0A0N1PHG6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1145"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1259" mass="139480" checksum="E7DF32AAD742F049" modified="2015-12-09" version="1">MSPLKKSIHLYLGLHLYPTKYILKVRCLSGSKADQQHRREVFGSNLIPPKPPKTFLTLVWEALQDVTLIILEVAAVVSLGLSFYKPSEDESDVGHLDEEEGHYQWIEGLAILISVIVVVIVTAFNDYTKERQFRGLQSRIEGEHKFAVIRGGEVKQVPISEIVVGDICQIKYGDLLPADGVLLQSNDLKVDESSLTGESDHVKKGESFDPMVLSGTHVMEGSGKMLVTAVGVNSQAGIILTLLGAAVDKQEKEIKQMKKEAKKQQRKGTQRKSLTGDEDATLAASSNSHGANHREDNHVAPTDKPAETSHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILVVQFCVRTFVIDGKPWKATYINNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVTPNFRDIPAEVGETMIEGISVNSAFTSGVMPAADPTSPPIQIGNKTECALLGFVLALGQSYEAVRERNPEESFTRVYTFNSVRKSMSTVIPYKGGYRLYTKGASEIVLKKCSFIYGHEGRLEKFTRDMQDRLVKQVIEPMACDGLRTISVAYRDFVPGKADINQQYYTVHYSAAFFCPCVKQALDPCSFIYGHEGRLEKFTRDMQDRLVKQVIEPMACDGLRTISVAYRDFVPGKADINQVHIDQEPNWDDEDNIVNNLTCLCVVGIEDPVRPEVPEAIRKCQKAGITVRMVTGDNVNTARSIAIKCGILKPTDDFLILEGKEFNKRIRDANGEVQQSLLDKVWPKLRVLARSSPTDKYTLVKGMIESKVFDTREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAIQDSPLKAVQMLWVNLIMDTLASLALATEMPTPDLLQRKPYGRTKPLISRTMMKNILGQAIYQLFIIFSLLFVGDRLLNIPSGRGQPLGSEPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVFEGLFTNPIFYSIWIGTALSQVIIIQFGGMAFSTAGLSIDQWLWCLFFGAGTLVWGQLVTTVPTRKIPKKLSWGRGQPDPETIQPGPDYDSDLDKKPRAGQILWIRGLTRLQTQVIIIQFGGMAFSTAGLSIDQWLWCLFFGAGTLVWGQLVTTVPTRKIPKKLSWGRGQPDPETIQPGPDYDSDLDKKPRAGQILWIRGLTRLQTQVRMRTRNTRLGDTVTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHL3</accession>
    <name>A0A0N1PHL3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A0N1PHL3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032150">
        <property type="entry name" value="DUF4820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16091">
        <property type="entry name" value="DUF4820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="335" mass="38199" checksum="65C0DC609087CB1F" modified="2015-12-09" version="1">MEVLGFIQEMLHNVAEYAASYRLGQSLLRQADRLLWTIEKTARWAVPPPLDQDEGPQPELIRPLPWVFFLMLLVALRVTRESISLINLVLGKPPLRSADVVTYIQGKRRYLRTLKYQGSRAMRSRSTAQPTSWYSSVQSLFEFTMCFPRRHNYDNNNTARVSNNDEVLVVKRNKDGGQEASLVTTTSETNVERLIEKMMVDLQADSDDDSSYYTLTNPKSDQSTDDADFEQEVVQNDITNNSKHQNDSCQSNTSNNENNIDKLNHRDTATNEEGKCEEDNLIPSEMSVKDESFRLLQSESSLEHNNKEGLSTLKSGMANGKKLYKTPRSDKGIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHV0</accession>
    <name>A0A0N1PHV0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459627">
        <property type="protein sequence ID" value="KPJ20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1PHV0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1PHV0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1659"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1807" mass="207206" checksum="0C86B0540CD330CB" modified="2015-12-09" version="1">MRRLNIDAPPPRDSLPRISDPNHRCDRTHSVDSVASYSSQNHVDRIRTQNFSAASCQEDVDFGSIKTSLFRRSTSNLDYPIKRPDSVTSNTSSTRSRLRELVERKSSSEEHKPAANTVADIQYFENPAETLEFDNPRNSLDSRNSQEERPKKKKQSKNKEKNKDYCEIKNKKHEKYQSKLAEYYKLPIQLPQDEFYQHLTRSRAAEELLQKRFSNSDTEFNGSYGRLCKHKEIEGSTNLRRSRSLAVIREETFTDLQIQNHAKNKRSQLIPRARLFDKPCFRDRLPGRAKYQTKEEVLEAIYIDSTASCFGDINRSKVDDIPDDKVQNGSGKEDDVSQNESRQSQSIGGSWPNLIEESKQTNLSEDSIGHSRNPSEIDSLDSNYVRKHYNFEEHLKSYKENSDTEHSFNSGNINNKELYIANNDHNGEIEEEAISKNKSPFHSEENISITRSDQPKCVHDSILIPEKDDSYDEISIRSNKSPIQEIYDTAIVNSTKTSEDKDIDLQSVISENDGTISSPPDSITSYISISIASSTDKSQKLEHLANSLAEKIDEYCDTHFNENNSVISNNINTDYHKNSDTDLIYTKVQKKTFADIRKDSLKKREDKSPSNEIYVNNTYIENKNKKNNCTSTRNITTEPFVTTLIENQYYSLPDINISKCLRKSERIDAQLREEDKEDIPCENTYEIAHTNFKEILAAKSSEQYGHLNRSYNQSPQLATNTTVYVPEYKEATIFNSFTKLDDDLESIVTIESSNVDDQNYYNSGVHHQNEREINEIEGTIRNNKIITKAESLKLSSSVIRPDIKISKSLSNDNINKSVLEKNKKTNIRKHYSLRQRDPSNDNIRIPSPDTVEKTLHNCIETENLKPKIPEGVKSNSLLSRVQSFKTSSESNITILPLSGHQTIVIDPPITKSVTDLCHTNTTVHTPEILQKESKEEKVEETNHNSLGSIETSNFYIPKDPFITIKLNKVVKKTIPKLTKEIPNQTFIEQVKIDKPPSKLIIKDSNNSTITSTYTKATDKMTRPQVIRVVDSKSKIVSSNNSTESSNCEISNISNKVNSNEKPEKKDDHFENKNDNKNEFTVKEKLHNAIKTDLEYQEKINSVKSYWSKLIEKPTEDHLKQEVTENEKSAPNNNITTKVEITETKNDDTKYVPEISVGSIIKSLESVKIVDSIKKISQTTKKLQLWKEETEKVKSDSEIEEPTVQKIKKESEGTIYDRPKPTKITKEGHQDMSRDTPEIEIVELSSEDNQNQKTQATIIKAKGYEKGCDEFDHVRYKVMKSELFKNSMIANYRKEAQFDGLLQYLQDYSFQELLVNNNIVIIEPVRTKVEPTPKKNNNLDPCKIPSSLLKKNDNNSGQIDKSKNAIKRHFFYHPIRVNKEIIEEELPNPDTVKKVRNLFEDTLKMRSPVSQDPPLVNENSRLTRRATSYRNISEENKTSKIGGRKKVIRQLTIDTNIGNKKWDNASLSSGVSSGDLSSNNEFDQDGPYSSKNLKDNVYSSSDEYLYDSMSQDFCCESQYVSPEILKKIRDCGTSITYYGGKVLNSKTGSSVSPMTKVIMDEIKSLQKNCSRDCYSCQTKCKGDKCSCLVADRHAQMVTDKQNLNISEERLNQENYDRIKRSDGFPGFKFKLVKSNSCSSRLELTGTDESQNPRLKYRKQRSTEDPPLVHDEDNSVKNKICRLESYNKGIVKTPFENNNNENKKLNLNLRPQVNKVSEEKEEISIHSSNNNEHLKKDKEREDEESYNNLVQCDNQNINDAHTFEKKFYYLNENLDSKNVPTGKFGEMVFEEFEVLESCYDSLNSNKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIH1</accession>
    <name>A0A0N1PIH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460299">
        <property type="protein sequence ID" value="KPJ16159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIH1"/>
    <dbReference type="InParanoid" id="A0A0N1PIH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="80"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="492" mass="55700" checksum="74376ED7CE49543C" modified="2015-12-09" version="1">METNVQFSWGVLKERLARVWADEEEMLKRVYEKNRVFADTTEDSSTSSGHRGHRRTFEIKSTPANAGNYDFVSARPPGKKTNVLESVGHLVKSCLGGGVVAIHESYKACGLWTSMVLTIFIGFLISYCMYMIAKSAHRLYGRLHISTMSYPDVAEAAIAICPFPKLRKYSKCLRYAVDFTICVDLFGSCCVYQVVICRTIKQLVEGTDTVTLEGNPPLRVYILMLLIPCILICMITTLKYLAPFSILADVFLLILACATVYYGCLYSKVSIFEMPAFKNMPGLFEFLGVCVFSMEGVGVTMAIENNMKEPKKIGRVLALGMSVVVGIVFVIGTFGYWGFGEDSKSPVTLNFPFTAFSIALKVFMAIIIYVTFALNFWVPFDLVWFYIKKRYPPSKYWLWERVYRGSFVVVITLIAFVFPNVSAFIGLLGSFCLSNMGFIYPAFIELCVEWEYPGLGFMKWRLFKWIFICIFGVFLGVFGTYTNAKELIRQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK05</accession>
    <name>A0A0N1PK05_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_01997</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK05"/>
    <dbReference type="STRING" id="76193.A0A0N1PK05"/>
    <dbReference type="InParanoid" id="A0A0N1PK05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000022">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="247"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="528" mass="59573" checksum="56F0B6B6C2A1D69D" modified="2015-12-09" version="1">MREIVHLQAGQCGNQIGSKFWEIISDEHGIDQTGHYKGDSDLQLERIQVYYNQAADGNRYVPRAVLVDLEPGTMDAIRSSSYGQLFRPDNYVFGQSGAGNNWAKGHYTEGAELVEAVMDVVRKEAEPCDCLQGFQLTHSLGGGTGSGLGTLLLGKLREEYPDRIVNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLRLASPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARNSQGYRALTVPELTQQMFSPVNMMAACDPRHGRYLTVAAIFRGHMSMKEVDEQMLTVQDKNSSPVNMMAACDPRHGRYLTVAAIFRGHMSMKEVDEQMLTVQDKNSSYFVEWIPNNVKVAVCDVPPRGLKMAATFVGNSTAIQEIFKRISEQFTLMFRRKAFLHWYTGEGMDELEFTEAESNMNDLIAEYQQYEAFLHWYTGEGMDELEFTEAESNMNDLIAEYQQYEEVGVEEGEFDDQEEIPGEDYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLG1</accession>
    <name>A0A194QLG1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-scruin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_14651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLG1"/>
    <dbReference type="STRING" id="76193.A0A194QLG1"/>
    <dbReference type="InParanoid" id="A0A194QLG1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667:SF0">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="263"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="761"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1117" mass="126691" checksum="854696E723D64B5C" modified="2016-10-05" version="1" fragment="single">ERYHITVKPKLLRSSSLSDLATNSSDFTLDFIKDSSNLLNRANQITSQNCSGDTCRPYIYNSLDARYMSWNNKVKKFKKKIEMSPEPISKGTKDYDPDQNISSCAENSSVCSTDEMSVQRIAAFPFKSTPSGNLKVQSNQVVFQSSTVGVLLADPTQAKVKVKFEGKAAGEPENKIENNYTDENDSETQVKYCHKDSLNMRLKAVTERHSKPKTPVIREEQGKDLGSLGYAIAEPIDWSRVQLPKKLDLFQEFYRRILNYIHTDTIIHIGDEEFHCHQIVLQIYSSFFDSNNLREIELPISSVTPEAFQIIYEWMIFSNSESNKVLKRENILELFCAAQYLAIKDLEDQCWSFIVHEELFTEDTAFALYREARSKGMTPVMDIMVPRVMRFFLPLVASRDFLELDPDEIMTFLKSNYICVTSEIEVLMAGVRWLYGNWPARRRLVVDIMRCIRFGLISPWQLVDIKRNPDNAEILEIVNDPEVQQMVDDGLAYVIIKYWYGNNSKNYYHWIDVLGLSEPAERNWIGEEKNHVTYKDFLKYLEHFMVPKEQMYQQMSMMQPPRRTDDLPSTLRGLDADKMDMRRPKMEFPLPGTLKGLGGDKDKSFPTMSEFFENRRKTKEANQSRSPIRSPNQGSECLPTVSQPTPQTSRKTPETDRKLQKQTDLNEPRLFQANQTLIQKQVQQIQTATLPGPNLTQQHAEMYEPPEKDSSDNFNTTKSVSSSESIDTRYSEKTQYISKTCDTRHNSVAACYLAAATAALAGSRRESQTSPTSGSRDQTTMSSSRPEQSPRPAGPTSQNVITSPQVSLFNQSKEALAKINMNKLSTSILGPSNKTYIVDGSLFNWDRETVLVFGGTDPHTGYGVGRNTGKDIYRFDPVTNSWDYVGDLPEPRHHHSVAFLRGRVYLVGGADPRDDDTRGKSVVVSTVWSYEPVTRSWYSESGLAIPRKNFGLVVHRMALYAIGGQDKKGRVLRSVERFDPKTGSWSEVRSMGVARMAMAAVKYREYIWVAGGMTGEKKNPVCKDKTPSSVGAIDIWDWKDRTWKQETEMSIPRHGHALAYLGTQLIIIGGVTTIYMRALSNVESFCCERGAWIRGVATLPSPLSGHGAVTLPPASLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMB7</accession>
    <name>A0A194QMB7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60 kDa SS-A/Ro ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_11725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMB7"/>
    <dbReference type="STRING" id="76193.A0A194QMB7"/>
    <dbReference type="InParanoid" id="A0A194QMB7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="TROVE" evidence="4">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ06678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="548" mass="62217" checksum="0FF7DEF0B89C735B" modified="2016-10-05" version="1">MEPTKLRPELRNKLTRFLHLGREEPKYYPGCWTSHDYYDASKLKAIDFALENGSNNTEVVDIILKAHKQGWCTRFETIAFALTKCLIHGSPAVKEATYKAASEICVSAEQLMTFNNFTWILKTGNGRGWCKHVREWYMKKEPMELAKELTRVKSRHGRSHKTLLRKSHVKIAENDHARGAVIKYALFGLKRAKQLVDNAEGTKEIFDYIQKVEDFRRCEDPVAAAAIVEKNSFTLDHVPGHLLTSQEVWNAVLPQLPLEDVLLNIQRIHNMGFLAADSTTTAIVVSLLSDKNIIKKSKVTPLAVYIALVNYQKKSKPLKSQKAKVAMEKTSRRRLRQVFDSETGEWQWTVTKRHPKEVKTWGIEKQPNQLVIDAMHKLIDLTWLLTPPTNVRYLITLDMRHHMFKGRHFCKNFTVPRKGKKTATKTSPGGGGDADSVKVGSKKRLSAECFFNRYVTPGHAGESVSVGDSGVKDLTYNLQILGSNPAMYQCVFRFSIDICTFMRSSYGEGKHRDATCTYLRRNSMRCVKSTNPHLASVVDYGLVTPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMC6</accession>
    <name>A0A194QMC6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">RR48_14248</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">Ya'a_city_454_Pm</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMC6"/>
    <dbReference type="FunCoup" id="A0A194QMC6">
        <property type="interactions" value="1135"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMC6"/>
    <dbReference type="InParanoid" id="A0A194QMC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KPJ06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="460" mass="51875" checksum="173CBDD10488CABD" modified="2016-10-05" version="1">MRSVQLSPDSWWHPANKVHRFLALLLMCFLCFGSYFCYDTPGALADNFKGDSHLNTSQFALLYSIYSWPNVILCFIGGYLIDSIGGESLQVAVNSYVVLWFKGKELNMVFGLQLSFSRFGSTVNFWVMEPIYRWVANYYGGYERLGVALFIASFTCVGSLICGLILGWMDYRAEKMLGRHEEQSDAEPFRLLDILHFKRVFWLVSVICVAYYLAIFPFIALGKLFFERKFDFSPQDANTVNSMVYLLSAALSPFFGILIDKTGRNVMWVIISTITTIGSHFLLAFTFVNPYVGVMSLGISYSLLASGLWPLVALIVPKNQLGTAYGICQAVQNLGLATVLILAGVIVDKYGYLMLEMFFLGCLFISLIAAVLIYIVDSANNGVLNMSPSMRESMTDTSECRDETANLLEHEDSSDQEVTDSRDRPDPKEPQRDFTQSQSDRIRSRYIAQLLPNTNIPDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QML0</accession>
    <name>A0A194QML0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock 70 kDa protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QML0"/>
    <dbReference type="FunCoup" id="A0A194QML0">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QML0"/>
    <dbReference type="KEGG" id="pmac:106720213"/>
    <dbReference type="InParanoid" id="A0A194QML0"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="474" mass="51696" checksum="DE275202F299B378" modified="2016-10-05" version="1">MATAYGIHIGNSSGCLAAYSNGAPAVIANDAGDRVTPAIVALNASEWEIGLPAKSGQPSSKSIIKHNKRLMNCDFTEEDLAYVEASSSCRIQNEEKVVYEFETSETTLCLNPDKIATKIYSKLFTIASHSVGSDGDLKLVLAAPLHWSNASRDRLTKCAELAGFDVLQVISEPAAALLAYNITEDAAEDLNVLVYRLGGSTCDASIVKVSAGFMTVEKNIFRSDLGGQCLTQDLAEYIAQEFKQKWKLDPHESRRAMAKLLHHADNCKHVLSTLNSAHVFIESLLDGVDWSQNVTRARFENIISSRITACIEPAQKAIESFDGKISKIVLCGGSMKIPKLQSAIANLLPEAEVLSGISPDEVIAVGCAFEAGLLLDMPESNLTDINTEVEFLGRDIYMKYLDQTIKLFKEGTAPFSQNMTTVDPGEDVKNINFTLHENPDTEEFAAESFNVEKLSKPFTLKATLEQSKISLQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNT1</accession>
    <name>A0A194QNT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ganglioside-induced differentiation-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_07599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNT1"/>
    <dbReference type="FunCoup" id="A0A194QNT1">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNT1"/>
    <dbReference type="InParanoid" id="A0A194QNT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188">
        <property type="entry name" value="GDAP1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188:SF1">
        <property type="entry name" value="GDAP1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="307" mass="35553" checksum="5E1D6F3F48DC3524" modified="2016-10-05" version="1">MHYVQKYLEKYQLIKTSNNKMNSRSNTNIFLYCNYYSFYSQKVLMTLYEKNVDFEPLVVDITKGEQYSPWFLELNPRGEVPVLKVRNEVIPDSTRIIDYLEYHLDQELTPIINVSRDSKVMKNINHFRDLLEALPAGVITVGSFFHPHLCGTPKLPFVFPVREVLKSGDLVSSKNLRKLAEENPKAKGILLYKAEIQDRKHEILTNEEEYLKVLNIVDAVLTQVEDQLTEQNEDCWLCCDKFTIADVNLSIILQRLWELGLEERFWTDGKRPHIETYFNKPPAYVGAAGAVSIGVVLALAYMLKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPA9</accession>
    <name>A0A194QPA9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nanos-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_11857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPA9"/>
    <dbReference type="STRING" id="76193.A0A194QPA9"/>
    <dbReference type="KEGG" id="pmac:106719593"/>
    <dbReference type="InParanoid" id="A0A194QPA9"/>
    <dbReference type="OrthoDB" id="10010129at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ06810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="299" mass="32791" checksum="87EDF67632C2F9D7" modified="2016-10-05" version="1">MHYHSDYSSGSGTSLDSYSWGGSQSLPTPQSNLSALDQATRGRSVSYADVSARTHVDRVMEEFRLNGVDSPYDPDADGANRRAASMVLQPSGFRGKPIRAAQHTAHQMSQQTPVLSALDHGYASTENMGAGAAAAENITAEQYRVLNSLPRAVVRALLQLLRSFDRPPQVDENRGCAFCRANGERVSYYQSHCLRRAGRVTCPVLREHVCARCGATGDSAHTNNYCPLASQLERERSAAIMRSVRMSSERRRWQRERGPTRLCDTAPSVSAAVTVGGRVYSGEDTLDPVWAELEKKLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQZ8</accession>
    <name>A0A194QQZ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_14398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQZ8"/>
    <dbReference type="STRING" id="76193.A0A194QQZ8"/>
    <dbReference type="InParanoid" id="A0A194QQZ8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ05956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="14947" checksum="9CF21E09F95781F8" modified="2016-10-05" version="1">MILFGAPFLDSHEETLMLSALLTLLTVFPLVAHAGVESAMQLLFGVKHFSRNTIIEMLVNNALLTVCGAWLGAVVIPLDWNTPWQKWPIPCYLGAIGGHLISNVLTILKISLMSAADKYPILNFIVSVLNKFNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR56</accession>
    <name>A0A194QR56_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_08468</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR56"/>
    <dbReference type="FunCoup" id="A0A194QR56">
        <property type="interactions" value="1514"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR56"/>
    <dbReference type="KEGG" id="pmac:106718927"/>
    <dbReference type="InParanoid" id="A0A194QR56"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ07455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="332" mass="37571" checksum="60589D8140A4F977" modified="2016-10-05" version="1">MTVTRVAESRTEFKLKNLPEDAISSVKFAPKSSQFLLVSSWDCSVRLYDVTSNVERHKYNHELPVLDVCFRDAVHSYSGGLDQTLKMYDLNASTETVLGEHKGAIRCVEFASEVNAVLTGSWDGTVKMWDSRVPNCVGTYNQGNERVYTMSIVGEKFVVGTSGRKIFVWDVRNMGHVNQRRESSLKYQTRCIRVFPNKQGYVLSSIEGRVAVEYLDSNPEVQKKKYAFKCHRIKDGGLEKIYPVNAISFHSVYNTFATGGSDGYVNIWDGFNKKRLCQFHRYNTAVSALSFSHDGSALAIACSQLDESQVEDPKPEDTIYIRYVTDQETKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QS08</accession>
    <name>A0A194QS08_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QS08"/>
    <dbReference type="InParanoid" id="A0A194QS08"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="572" mass="62048" checksum="FCAA5E56A35C13CC" modified="2016-10-05" version="1">MAQKDDSLFLLEVLIDKIVLSKVPCFTDKDFRTCVSIECPSVETLEICDDETGTNVARSDGPFVKTFNSGKSCLFSLKEDQISKAMSKFPINVSVFQSLPCGCLPSKVVLGECVIDMTKEFVESRNKYLEDPSNVSYQALKDSFKIVSKDQGEAGEIIMFLRISCFGKLIVTKFQGTGASNAKSSGASASVDRSCLPQREYQSAQDPCVCGSKRYLGGGSGPSCTVSGAATGGVCPPARDPFNSMPCEEPDDPCFCSGPKSPTKQKMICRNTDQYCLHVPKGRSKQFEEIGTNLGGNELKIKVPATSAIIKKISQTHCSMQSPYTENKNEGPCQAPCGKNQISLTMPSEAICCNGAQPANTQFTCTTEGCVQASKHGQAALARGDTKQTNVLTSQNKNTFVLKVAKTANLGDRKCKLEFEVVTPKGLDKKPPVLKANARIQSDPDCDCCIDCCPPGNKIVFQLPMDSCSTGHKQRAHFNFTSDGVGDIAREEPGQLVPHTSPDYHGVVYDFPSQVIKMRVSKIVEMPGRKSKLEYQFVTPIVNQETVIPVSDTRTTQCVPRTCPGCCNTRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT56</accession>
    <name>A0A194QT56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial dicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT56"/>
    <dbReference type="FunCoup" id="A0A194QT56">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QT56"/>
    <dbReference type="KEGG" id="pmac:106718066"/>
    <dbReference type="InParanoid" id="A0A194QT56"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="199"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="31809" checksum="3F72F7B16174B8BD" modified="2016-10-05" version="1">MSKATEIRVSQWYFGGLASAGAACVTHPLDLLKVQMQTQKGKNISMLKLTGIVLKNQGVMGLYNGISASLLRQLTYSTARFGIYEMAKQHLAPKNGQPISFFMSAFLAGLGGFAGGFVGNPADLVNVRMQNDVKLPPEQRRNYKNAIHGLWKVATEEGVLRLWAGASMTCSRAVLMTIGQLSFYDKIKELLLGTKYLEDNVFTHVMSSLLAGGIATTLTQPVDVLKTRAMNAKPGEVKSILTLVVGTAKEGPLAFFKGYIPAFARLAPHTVLTFVFLEQLRINFGTIKANTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN9</accession>
    <name>A0A194QUN9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN9"/>
    <dbReference type="InParanoid" id="A0A194QUN9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="6804" checksum="D695E6BAD93B809A" modified="2016-10-05" version="1">MIAASRMSLTGLDRVLIAGAVGSVPCARAACSAATVGRAAALQKGPLCGCAHRVLFCRKTAPKSFDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV04</accession>
    <name>A0A194QV04_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Voltage-dependent T-type calcium channel subunit alpha-1G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV04"/>
    <dbReference type="STRING" id="76193.A0A194QV04"/>
    <dbReference type="InParanoid" id="A0A194QV04"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8145" checksum="F0A3A3F232D504C5" modified="2016-10-05" version="1">MPYYGYREEGPGSESSGGCSDSEGGNSDSEGGLSTESSSGQGLPFPGFTPVALRYLTQETRPRSWCLKLITNPYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QV44</accession>
    <name>A0A194QV44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ring canal kelch-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QV44"/>
    <dbReference type="FunCoup" id="A0A194QV44">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QV44"/>
    <dbReference type="InParanoid" id="A0A194QV44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF34">
        <property type="entry name" value="LD40565P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="175"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="345" mass="37682" checksum="268942756F73EB83" modified="2016-10-05" version="1">MNLLAVTPHLGNFRVPLWKCGKSASSFMERCIAFIGDNASECVKTNAFLNLPKEALIKLISSDFLCLEEEEVWRCVLAWAKQRAGVTQPTAHWAEEERARVCHHLAPLMQHVRLLLIDSAVFAEEVEPTGAVPMELSLERYRRAALHSAPRPAPRPDPDKRTQPRLAVNLFAGSAILQQDKSAFQSLINTWCGSPKQSWRLVFRASAHAFSAHAFHAHCDGVAPVLLLVQLQRGEVIGGYCEAGWAAGGAGGYVSAERALLFSLAEPPARYPLLKKPFALCHHPDCGPIFGAGADLLVSHQCNSNSDSYSNLHSYGDAAPAAPAASLAPDYNFTVREYELFTCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVS1</accession>
    <name>A0A194QVS1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_11217</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVS1"/>
    <dbReference type="FunCoup" id="A0A194QVS1">
        <property type="interactions" value="1399"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVS1"/>
    <dbReference type="InParanoid" id="A0A194QVS1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="14">
        <location>
            <begin position="212"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="308" mass="35754" checksum="B5AC2A7D62946141" modified="2016-10-05" version="1">MTAHQSELLRSGLDNFLMIGDVYRRDEIDSTHFPVFHQVDAVRSQRKEQLFQEHSGLELFEPTFDSKNPHMFENSINDPNKQSCHSLEATKLMETQLKKHLIGLVHALFGDNVKHRWVDAYFPFTHPSWELEIFYENNWLEVLGCGIVRNEILANAGPNNTIAYAFGLGLERIAMALYKIPDIRLMWSEDSGFVSQFQNKKLNEKITYKAVSSYPQCTNDISFWLPSDVTIDTFTNNDFYDLVRDVGGDIIEQVKLKDKFVHPKTKKHSLCYSIIYRHLERTLTQAEVNKVHKEIEKAIVKAFNVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVT3</accession>
    <name>A0A194QVT3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVT3"/>
    <dbReference type="InParanoid" id="A0A194QVT3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120274" checksum="067CA806097F62F0" modified="2016-10-05" version="1">MTDSEDDLLENYQYSFQNEGMAIRARGPNIDFETISLQSSTMQMLPGNVNRPKYGHMNNGQRSLYYRRETSPMSAYNVSHFSRPYNRSFSALSHIGSQQSIYNRGNRSPASVRSLDSNATVTASDIVVALKNEHFNKYDQKLLKAACYKFLKNKSRKRLEYMRNRRILMNKIRRRHSTEDLGELASESSSSSENSVSPKIFKPKDKIIRNNVNQDCMENNYTNVLDVNQKQNVNGEETSVTATVSKQCTYNTKENSFLIKDRFKKGSLLPSQRFSNSNNGPSSVTNLSHNSNKNKVHGLIRQCPREINENNSDEEIFSVPINDRLSGKSQTTTRKRTIDSNDKEDNPKAPKQMKIDTPKKTESLNCVNNIKNDFNFAKPQMPITKFSKLKKKKAQPEILISKSSQPLSVINETVLNTLSPIQIQPIQESTREDINNTDKRSSINNEPVNTTNDVSKRPSFVKRKLFTQKLDVIEAKIDTPQSSPSVDKYVGNKEKTKPRKLASSQSCLSRDVAEDNNNLLNLLHKIVPVEQMSLINSTTNKPDTGNRKSEGDCAKWDIDSVLSTCNADDGSDTYTDEEILANGKNENKKSNEIAQTNVASKEVEEIPPKNKIHRKTVGIKDGNENTTKTNQKSFCDTDIESDWESNVFLPSKLNNCQRSKAAGVDKVIKNKSAAVNSLAKNMNVNCLNVDAIKKTANNCQPSIWDTDFESDLESYVILPKKTGNCKTNNATINKNHNNQENCVNNKNVQVNSKTKKNNSKSVNIDVNKTVANNYQKSIWDTDFESDLESCGILPQAKKAKVNTEENCENKNGAVNSKTKNVIKPMSQKVNANKKTARNQPKSIWDTDFESDMDLSNKSGICKSNATAITQNDSNKENIQNNGSFAKQSDAKRIMVVKCQRINTNMKTNTGQKLISQYLEADSKDNKATSNKRLKKDDNVKVNSPVTKTKQTGIKRTPTKYVQDKNVSKKKAVDIQKKNTSPEPDNNVSNVSGRWLRANRRACNSMNDLKAKDSFKTTLISHRMTRQMTEMLNDPDWTSNTIKPNVSTELNISVRSLRPRKKRVPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVV6</accession>
    <name>A0A194QVV6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVV6"/>
    <dbReference type="FunCoup" id="A0A194QVV6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106718743"/>
    <dbReference type="InParanoid" id="A0A194QVV6"/>
    <dbReference type="OrthoDB" id="7466056at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045843" description="Cuticular protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22619" checksum="49AD0EA9D2A58635" modified="2016-10-05" version="1">MFKFVLCALFAAAVAEPQFLYTPYSESYIAPATTTVTKHASSVVTSPYYSSLAYEVPHFIKKREAQFIPSAVVPTTYLNNWATPYNYWNSNAYLPYASALNTHLIKKRSAGLISHASYITPYSSYIAPGALTYSSGLYQGNPLYSSYIAPAHFIKKRSAQWATPYLAAPIASTYVAASPLATSYSTAVLPGNAYWSGYGAFPYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW02</accession>
    <name>A0A194QW02_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW02"/>
    <dbReference type="InParanoid" id="A0A194QW02"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="125" mass="14195" checksum="C739EC7B07F7E0FB" modified="2016-10-05" version="1" fragment="single">RSRCCPYDFDPSLCKIVGDRLLCGYNRNIGGFQSDSDVELRNGCRIRGGRVECGYVNGPFINPRRPPIDNVLPMYDDDSTPVNDVNGSGPENDSHKEALKHVTSKMFREPTTRCLEMRERIVCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWF5</accession>
    <name>A0A194QWF5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWF5"/>
    <dbReference type="STRING" id="76193.A0A194QWF5"/>
    <dbReference type="InParanoid" id="A0A194QWF5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="274"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="54465" checksum="6F4DEC302B6B8705" modified="2016-10-05" version="1">MQRHTFIPEAFTSDLQVHWGQHPLRPEFLESTYFLHRATGDDHYLHVGKSVLRALQRHTRVPCGYAAVNDVRTRVHEDRMDSFVLAETFKYLYMLFGEDRDLPVHLEDYVLTTEAHFLPLALATDGLNSTLALNIDDQDEDKYVKTCPSTWSLEASSVRRPLRTLLGGAGRPPARPRPLTDPRQLLALADMGISVLTLPDGRVQLLYTVATAKSSKEASEGMTFMREMSKWNTLSDTENGVVAAGVATSERVLAAGPAHFGRQVTGGERLRGVPLLAEPPEACSALANAPALAGMFGVARRGRCTFAQKARNLQAAGARLAIVLDNIDGTSYGSTALFAMSGDGIDDIQIPTVFLFSQEADHLLDQMKSDPEMVVSVGELESLKRLESCSEGACEALLQPAGAPPHAPPHAHTFDHLKSVLSQLVAQFELSLAGEEAGEEAAEPCADGDSSDLYVTKTKFVNDESRAEALHNNCSGEGSCAGTTEDSQGDEGAQGQGEGDDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWU7</accession>
    <name>A0A194QWU7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adult-specific cuticular protein ACP-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWU7"/>
    <dbReference type="STRING" id="76193.A0A194QWU7"/>
    <dbReference type="InParanoid" id="A0A194QWU7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="100" mass="11315" checksum="B10DB64AA7B475C1" modified="2016-10-05" version="1">MQGMEGYKHTLMEDTMELRKDIPIITDPHTGDHKSQWESRDGDVVKGAYTLAEPDGTTRIVKYTADKHNGFNAVVKRIGHAQHPQVYNTHNDGAGYYGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QY78</accession>
    <name>A0A194QY78_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Breakpoint cluster region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_12284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QY78"/>
    <dbReference type="FunCoup" id="A0A194QY78">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QY78"/>
    <dbReference type="KEGG" id="pmac:106717775"/>
    <dbReference type="InParanoid" id="A0A194QY78"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.30">
        <property type="entry name" value="Bcr-Abl oncoprotein oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036481">
        <property type="entry name" value="Bcr-Abl_oncoprot_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="497"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="697"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="900"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1277" mass="139898" checksum="170365EEB58F9F48" modified="2016-10-05" version="1">MSVFGDFQRVWVQRFPESALPAAWEEDVRANLAKHKQKVAILREELEKEEFYVEYLETLLSDVEKHKAAAQSNRAAPPSGTDTHDDKTSDSKQESNTDSLSKKSEISLTSSNNEELTNEPLETEEVHLRPKPVHIGERSSVNQCITELSTTLAVEARRRCNSEVVQRTEPENDSNVAVEQKSPTNAKNRPMSQTGDFVTVIEVNGLKAAENASKKTDNSPQSPESAPADSTVASKKKVPPKPPPKVFSKRGASLPESGLPEDSPPSSLGRRLRNAESRESIASRASTPSISERVKSYESINSLSSERKRSGGAATPRSIDEEITSTTPDLPEGNDADKSAPVSLESIPAAVPTNEDEPYYDQVPVDINDGEYVYIQAGGTGSSEDASSGTSTLPLSTGAGPTAPSAPSAPTAPRAPDSPTCATAPNYVNIHYFIQQAGEGAEPSEAGAELADSSDTPLLLRTISSDTEASATPPVLRKLQHQESSTSSNAEAERLTMHRCIVTSIIESETVYVECLYVMEKYMNAIKATLSTSQPVITEEEFNTIFYKISELHELHKNFLEGLKAAVSSWEEPLSVGIHFKKMAENINVYGAFLHNYGRATDAVRRRCGSSPRFADLTRQIACRGQPMSLDDLLHKPVARVQKNALVLHDLIKYTPASHPDHAMLTDALNMTQHFLDEFNIIQTKSLFPNADRAQRRLVKNSFIVELSDGHRKLRHLFLFNDVIACAKYKASGRDKFTFELKWFIPLPEIVVVEEESAGAGAAAEARETSPANIVALKSQASTVRDQILAEERAVHDDKKIRIGGRGAAEKQRKKLTELEGQLVLASPNLVFRVGAKPPGATALQRQHIFFLSSEYERTQWIDSIHALQASSAPPGGSNAISMLELQAWVTACRSYLQTDMGSYLLRSGRDDSLLLGDLQLHIGGMTAPLDTAADYYVVVEVDSYGHYFRKAKSKLVCRSAQPRWNETFTLDLEGSQNLRLLLYEDAARPVLRGKCTLKLSKEWVAESASGGVSRTVCLGGGSLPLRLRLLPPERSSRRVPSAKPGVLFGAKITHVAKREKRNIPFIISACVREVERRGIHEVGVYRVSGSASDLNRLKKSFETNAYEAEQLLKEVDIHSVTGVLKLYLRELPEALFTDALYPELLRAWGSAQGVGTSVDSGPAHTRRHALLKCYAQLPDLNKNCIDFLLNHFVKVNQHEGENKMSLHNLATVFGPTLLRPSGAGAGAKQRTDLLAAGTVDAMAQAGILYCLLQQRQLAAQLSSHSHHRAPAPALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYC4</accession>
    <name>A0A194QYC4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_12329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYC4"/>
    <dbReference type="InParanoid" id="A0A194QYC4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="379" mass="42182" checksum="C4E039E5D192917B" modified="2016-10-05" version="1">MGIVCSAFSGIDLCTSRLANWFLCCVVLGGIMSFMQISVIYGMTIGYHTGQEQLAYFAARARNVQSTTRFSGPLLRAGTEVERRTEPFSPDTTTTTTTTTPPETTESVLGLEMYETRPRARTGSRDENGTPIFIQYVDMTTLGSLPDLEDFPRKFNGRVRRAKNDMLSKMFWRPFKKTDPHASTSTAKLELKTVAVADIGRDYIVIIMSQEIKKLVVSWLCCAMVLVVILLMIIVLTLYGITLGYHYAQKEIARFAAGEEGGGTESGLLREGEAQQQEIVEPLVRLVAVNRTQPETSGDMPGSFDVRTVSAQPLYLDSTPTPLVVLESERPIKEVELTPHEKELALKLIGRFRRIKRNNYTSYSPPTSRHEDSITTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYN1</accession>
    <name>A0A194QYN1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYN1"/>
    <dbReference type="STRING" id="76193.A0A194QYN1"/>
    <dbReference type="InParanoid" id="A0A194QYN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="882"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="882"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="912" mass="104310" checksum="635F5025D3F54045" modified="2016-10-05" version="1">MSSVERVPQVNNDSEMEEGEIVDEWDDLSDISSEEEFLLRQRLLVLENYNNVLERKEAKRVSLGKIGKSTNTLLPDLSEISATELEDNTTDYLKHSKNYICSKASYRRKKINLHSGHKKNKKRYHRKRKLEPKIISESSEDSDDEYRNKRRKLANAVALNKAKVDTSLKARLEEMLFGKKSKENCLNIENLNVNKKLIKEHDNSRIDNIKENTSPNNSEEKEILLCNQLNNIEIINETSGDSQKLKQDKNGIQLNKEEKDECDGKTHSLCSEESEKVTTANNHIDNMELSGKEIPSNKQDSDDDVELLRQHALKTKSTKTKSQSDTSKHAQNKPHSEDDESDTADLRLICLKSALLKKAIEMKMKQKMRKRLKSKSKSLQNDIVTHEEGIVNVTDIENNTDIESVDMDIGSDGDDKAKESNMDGNLNSGQITNDVNKQSNTNKQDELEDDEDLLRAQLLTSLTKNLPNLVAMDDVNSLENTEKESTTITKSKSNKNVPEEKKFIINLKDTDSEGEHEATKNLTKMHMKLSERLDFQEKLDLFLKSTRLQVENNILPDVVQQPPVSKPQAKYVPKAVNHLPKSEQIEYKNLVKRMAELEKMKQIRQASMNQKNDNILKETINPRNITVEAQKTFTDNLEQKIAISRKNIAEESAKMLKLKEEATKLLQKYKIVATELRNISTAITMNRKEQRTVQSKLARIRINHQMLLKSSNFKHSTERIPPTNQITNKVVVNKFQKENKPTKEEHKSTTQNITKTVNIANNLKKENTGPIPKQVDNSAYNQTDRIPKILDKEKKVLVEDNLDANKNKNVQSDTSCDKKDDIIHSVLEINCENISIENPRETLNNDKEKSKDTNEYQSPLNALGSNMSAYAHRGRLAIWQEDPNAFLCPYEVGGSCRDPDCKFLHPKIPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-11-27" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R006</accession>
    <name>A0A194R006_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor CP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R006"/>
    <dbReference type="InParanoid" id="A0A194R006"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000086">
        <property type="entry name" value="Alpha-globin transcription factor CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF21">
        <property type="entry name" value="GEMINI, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="276" mass="30699" checksum="52DF76887B88962A" modified="2016-10-05" version="1">MLVLEQRLSARHLGRGVILRARLIHGVEARGWRMKFSLLKAEVEIEADPDTYRELARRLKAANVHVRPARLSSRLPLAPKSVTSPMVVNKPALQQPAILATTNQMKPLYCQDGGDVKVSTPPCHSPDTILPDLPQPAEDPDKSGGLSKDASSAETQAWLSRHRFSQHAPTFANFSGADLLRLSRDDIIQICGLADGIRLFNALHAKRCPIYLKYKINTLDRLKSFLQQDGETVLVLGPNGARVRLTDELVRHMPDHSTYRLQRLDDGTLLLSATDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0D3</accession>
    <name>A0A194R0D3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cuticlin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_10164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0D3"/>
    <dbReference type="FunCoup" id="A0A194R0D3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0D3"/>
    <dbReference type="KEGG" id="pmac:106715312"/>
    <dbReference type="InParanoid" id="A0A194R0D3"/>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264793" evidence="4">
        <location>
            <begin position="17"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="53"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="46360" checksum="8A8F8AE3F4300B2F" modified="2016-10-05" version="1">MWSILLVVALASTARSKQIPTTTELVTTSVSTATDLTTPWPAALAPLDTLAVSCERDNMHVTISLAHTQPAGNSIYDTFNGIVYPAGLGSNSSCLREYISARGDLQYTLPLKGCNTMATDDEDGTVEYYNNIIVQPHLKLVTGQGRGYHVRCRYRRRDLTMFHLHRPHADRLTQLRDGYNSEEFDEDSGLLPSVTMKIYKGDPEDNEVASNVRIGDTLTLLVSLEKQRRFGLLVSECAVRDGLGWAEQSLIADDGCPLDGEIMGQFQYSRERQEARVSFPAHKFPYTASVYYTCEVKLCDLNHPTDCEPCAHKKGKRLRRQSEEGAPATVEVFSGLYVNEADSPENDEVTSEKKEDEICISQRNFAIGICIAGVILMICVIAAIAFILARRRNPKTYSRTGSSLYSGPYTNTGYSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0I8</accession>
    <name>A0A194R0I8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMRFamide-related neuropeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0I8"/>
    <dbReference type="InParanoid" id="A0A194R0I8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="55" mass="6280" checksum="0B214785D0F65413" modified="2016-10-05" version="1">MIEISYANYKNAPMNGIMFGKRVPSEYEIRSKTFTALCEIATEACVAWFPSQENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R122</accession>
    <name>A0A194R122_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transient receptor potential cation channel CG34123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_13175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R122">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R122"/>
    <dbReference type="InParanoid" id="A0A194R122"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="838"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="946"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="12">
        <location>
            <begin position="93"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="13">
        <location>
            <begin position="419"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="856"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1426"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1453"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1641" mass="185587" checksum="EB7FAAB5044EB45F" modified="2016-10-05" version="1">MESRRAMLRTPETDVCMNVEEARGVCQDRAKWRSMVSAYRSRCWCGLSKTAHGSSAACAGPGEAWVPARHTQPAPTDAYGTVEFQGGPHPTKAQYVRLSHDTRPDLIVQLLTREWALDRPKLLITIQGGKANFDLQPKLKKVLRKGLLKAAKTTGAWIFTGGTNTGVTRQVGDALQLERSQRAGRVVSIGIAPWGIVEGAHELIGRGRDVPYHAIASPRSKLAVLNNRHAYFLLVDNGSVGRYGAEIVLRRKLEKYIAAQKLHPYTHSSTPVVCLVIEGGTNTVRAVLEYVTDSPPVPVVVCDGSGRAADLIAFVHKYASESGEQTVLESMRDYLIGTIQKTFEVGLQQAECLYGELLQCTRKKNLITVFRIQERAEGGEVQELDQVILTALFRAQHLSPSEQLSLALTWNRVDIARSEIFVYGQEWPPGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKSGPSNTLRYILRDVRPHLPRGYVYTLHDIGLVINKLMGGAYRCYYTRRKFRPIYAKVMNKSVNVHRNSASFTRHNAGGLSLITGFMPVTSEMALFDYPFNELLMWAVLTKRHQMALLMWTHGEEALAKSLVACKLYKAMAHEAAEDDMETEVYEELRHYGKEFETKALELLDYCYRQDDDQAQQLLTCELQNWSGQTCLSLAVAANHRALLAHPCSQIILADLWMGGLRTRKNTNLKVILSLLFPLYILHLEFKSKEELQLMPQTEEEHLENESMEDDRSTKDPNDAEVGVVKRRTLSIKKIIPPGQQGKVTKALIGSGAECETRVDQNGKVGKIGWEPSYRELPEYHSPEDKRMRPLRLRKKIYEFFTAPITKFWADSIAYILFLLMFTYTVLVKMNLTPSWPEIYSICYILTFLCEKIREIITSEPVAIRHKFSVWAWNMWNMYDAGFIIFFLVGLALRLRTSSMDVGRVIYCVDIIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLLVVLMSFGVARQAILYPDKEASLYLIREVFFQPYFMLYGEVFAEQMAPPCGLPGLEKCRVGHWVPPVVMSVYLLIANILLVNLLIAVFNNIFIEVNGVSHQIFFQPYFMLYGEVFASEIDPECGMDIYDPKCVTGRWITPIAMTIYLLVANILLINLLIAVFNNIFNEVNEVSHQVWMFQRFTVVMEYEQKPVLPPPLIIFCHIYATCKWVTRNVSHKRFQYDNGLKLFLEKEDMERLYDFEEECVEGYFREQEVKLSNSIEERVRNTTDRVEHITTKMEDLNQKANCQIQSVQSVEFRLRKLEDVAEQTMNHLAVIHRFMATHPSLVNRGSTDTLGPPPPTFQAGGTRLRTASDRSEVLSDSDTGAARFAVRPVQEEDEQASQPSDDELPQSGPEATVEKEQEADSISTSSAGSVAGPDVTVIRPTVPATPARQRSSDSNRTEPSDEKKTVPSTTDDAFLPEVREVPTDIHNLRPRTTSAGTRRTANTRRRSEGGNDCGVGGHHSAQHLAPRRQHSQTHSEPDNSAVDVCSLHNSVTGRQSGWEATGGGVSSGRTRVGGAPRSLLLAMHEYTSITDELETVYGLFSPPHTPRTPITSRLLSPARAASPSLRRRHASEMSNPEFALFMEKEHLRGAEEDDYIIMENLIQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R186</accession>
    <name>A0A194R186_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R186"/>
    <dbReference type="STRING" id="76193.A0A194R186"/>
    <dbReference type="InParanoid" id="A0A194R186"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1181" mass="134677" checksum="D7822B962F60A013" modified="2016-10-05" version="1">MKRNKAINVTKRDIRSGIVEDRNYCYHYCPDNARTQIRQTPLGYNYNFKDLDLQNVSNWSHLTCSCRDSIGKHQEASYFSSKLKQMQPKVIDIGVGNVKVYQRRKAKKIYYPQTEERAVGTSINDYPKCHHFNELTHKTRNVVERAVNKKHLLNKKLSPLVRKKSNYTNPLTTLFHKQDLEHNVSTTLSLHNLVNASTQIGTKELEKSTKIKIFKELATNTELLENGKPLKSEVELSVEMSRIMSNKMGTGSSLDSLVQHVYNLDKPCNATLSTATIDPMENKLEREYRKIFSNQSKDCPCNKKISAANSDSLLRRFEALRRDMTLKDELKKNISKTSSPANEPKYKDVSVDSDGASLPECDDKKIITPISSDYSVKYKKEKSKKKSNAKLQKSSYWRRSDIDSDHQTKGRFKLWGRKISTDGGSHKKSKIKCSDGKKKSEASVKFSKLLKSKSSVKKEGKKFRFFKKKIKAAPRSRTDVMTGRCEVREGMSIQIGKGLLPQDYNKNAIQKFRLKYEDKLLNAWIRNFLTKSDEPRKERSAIYSSSVESNCSSSTDIGENSSSETDIQFTTTATVTNNSSFHKVNESPFMNFSNQYIQAWMLTKTILDRFNDTGDLKKIQRSYSADIFQDNKLDAPKTCKAVGIEIATQKNLRKLNYPVYDISTESGDDLEGTVYLLPKTYKHSDAYLQKCYHNWNPLDLDLWCISDANLPPSYNTNKDLNFKSYSNMTDDIQYTTLVSSCETFGNCGKDKRKKSLLKNHNNDYLNNNIGIRITPKDSLEVCKKRKLYSDSNKGRWKHDDLSISMSSSTKSKNHFRKLISLKPNKKRVTISSYEVDKESKPLLKENDLRKKNLQCLSSSCHVPDSMQTGRKLPPKLEKKPTRQNIAITATSSDMTNRTSNKPCDNAEVKCLKSASKDHLLSITDSCITYWKKHLCCDNALEERKKTCEKINDTKSGFFSDYFNPSSLIKNKYHSICRKFVIDKKPSDEFVKNSQNSKCRPQHSNSNLREQIKSEYKKCAITTDVQKLSTLPTSVEDKSCEAPGTDLDMNKKGRLIGLHFKKQPLRKSVSRACWTTGDKLECNDGNSTDTTTKVSSKETTGITQKCPPTTHTVSKNTNKEIKNIIVNKDINNVGDNNKDNDDKNKCTPCVIEIQPNTEITSESGKRICLGIDTCNDEQDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1N0</accession>
    <name>A0A194R1N0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cuticle protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1N0"/>
    <dbReference type="STRING" id="76193.A0A194R1N0"/>
    <dbReference type="InParanoid" id="A0A194R1N0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264849" evidence="5">
        <location>
            <begin position="31"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="350" mass="37371" checksum="4A8AA4FC6F13FCEA" modified="2016-10-05" version="1">MPQTQIKTIHTKYKLKRLAIVSILVVVSHAGLIDENHGQAVSSQSIVHHNQPTNGNGAGQIIHQSGPQLQQHSILEHSSPILQHIAPAIQAPVALARADHIEESAPAHYEFSYSVEDPHTGDHKSQHESREGDVVKGEYSLLQPDGSVRRVEYSADDHSGFNAIVHNSAPTAHAASAPVVQAAPIAHAPVFHAAPIAHAPVLHAAPLVHAAPLVHAAPIAHAQLAAVVLSVVALAAAGVVQLGHGYGGGSYDHEAVAYAPVAQLSYDGHADQHVDYHAHPKYDYSYSVSDPHTGDHKTQHEVRDGDVVKGEYSLLQPDGSFRKVTYTADDHSGFNAIVHNTAPAHPEYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2N8</accession>
    <name>A0A194R2N8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2N8"/>
    <dbReference type="STRING" id="76193.A0A194R2N8"/>
    <dbReference type="KEGG" id="pmac:106714074"/>
    <dbReference type="InParanoid" id="A0A194R2N8"/>
    <dbReference type="OMA" id="KGASKHI"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264872" description="Histidine-rich glycoprotein-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28711" checksum="CC79B3AB64B45687" modified="2016-10-05" version="1">MRTLGALCLLGCLLVVCSSREIGQKESDLVAAASDHKGHHHEEGGGKEHHAEHHGEHGEKGHKGHKGHHHHHKGEHGEHHKHHHAGHHHDHKGEHKKHWDEHDHHGKHHEHGHHHKGGKHHHKKHHDKGEETEGYHKKYHKDEYHKDHHFYDDHHKEGKHHKHGDHHGHHEKHGGHHKKGGHHHSGHDEHHYGKKGHHDKHHYDEDHKGHKGHHGHEEHHHHHHDHGKKGGHEDHKHWGYHHGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R522</accession>
    <name>A0A194R522_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chitinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R522"/>
    <dbReference type="FunCoup" id="A0A194R522">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R522"/>
    <dbReference type="KEGG" id="pmac:106715219"/>
    <dbReference type="InParanoid" id="A0A194R522"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF403">
        <property type="entry name" value="CHITINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="492" mass="55439" checksum="94DCAF59FB2EE155" modified="2016-10-05" version="1">MKFLVDFIFFPESGNGKVVICYMTTWSIYRTEDGKFKISDIDPSLCTHVVYAFAGFDENKNTVKSLDPGLDIGGQFEGGGYKPMAALKEKNPNLKVLLSIGGWNEGSLKFSNLAASSTSRKTFIKSLLDFLNTYGFDGIDMHWKFPTQRDGRAEDKANCVTLMKEIKEAFTPNRYILAMSLGAQYYVFEAAYSLPELNNYVDYFIVLAYDYHGAWGGVVNANAPLYGLNKDDTFSIDKTLRYLIYQGIRPGKVILGLPLFGRTFILEKPDTEVIEFGRTPIKSEGFGGPYTKELGFMGYNEICMELTKNDNNWTRLWHEKTETPYLRNGDKIITYDNARSLAAKVKKAMEFNLGGVMAYSIDTDDFKGLCDKEPDYVSVSFKGLHNFVEKFNRLASNPVLQKVLKNLNIPDAQKLASLSKSTEIAHKNHLWTTESIPSYPLLRAIVDSLTLATEEKIVMTDMVTLINEKPHVGNNAVTTNSMFTVVCYFCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6U3</accession>
    <name>A0A194R6U3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipopolysaccharide-induced tumor necrosis factor-alpha factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_10722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6U3"/>
    <dbReference type="STRING" id="76193.A0A194R6U3"/>
    <dbReference type="InParanoid" id="A0A194R6U3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="14028" checksum="285406212EBD0779" modified="2016-10-05" version="1">MFPTGSTFYSPMDTNSYEQIRQSNNDVYIEMDLLRVGSEPVGMRCPHCHEDVMTRATYKNTTLTHIIAVILGVLFWWLCCCIIPYVVRRWKNVEHYCPNCQRFLGVYTRKTTKEDRPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7F1</accession>
    <name>A0A194R7F1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane 7 superfamily member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7F1"/>
    <dbReference type="STRING" id="76193.A0A194R7F1"/>
    <dbReference type="InParanoid" id="A0A194R7F1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042502">
        <property type="entry name" value="TM7SF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937:SF3">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25992">
        <property type="entry name" value="Ig_TM7SF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="244"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="503" mass="56387" checksum="35258AA2B86311CB" modified="2016-10-05" version="1">MYSSVKPPLDKFYVSNQNAVDIKLYIVVHGYGSTDPVPGGCNMEFQPSISPYLHTSYTNDYVLVEAASARDSSDIACTSINDVNVVFYLMYLEERNFDSDTYFEGIKSMLTLDNITDNAEIVPQTTWRMRRMLGAYPGTGAIFVAVAYSALNSSAYSVYVPTYSYACSPLEESCELLGKVPQTTWRMRRMLGAYPGTGAIFVAVAYSALNSSAYSVYVPTYSYACSPLEESCELLDDVLSQLLCASLLFFGMFVCYFGHRFFKTEMFLIGLVSGVIITYILISLIAELERPALLGAAILSGTCFGFIWLLFWWFYGIPVFAVLLSTLNLGFLFAALMYFGLPGGFQALQVDFNFWTLFVLIMSITSLILLSTTFLSNILCCAILGGYATVYPIDYYIGSNLKYIIINTVRRAVVPKFNSAVLSPPFQWADTLITFLWLSLATTGFLFQHYQNRRKPPFPPPPRSIRPSVPDTTYGTTGRRYRDILQRPATSERRQTEYTPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R803</accession>
    <name>A0A194R803_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-glucuronic acid decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R803"/>
    <dbReference type="STRING" id="76193.A0A194R803"/>
    <dbReference type="InParanoid" id="A0A194R803"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="29878" checksum="BD9043AA540DE9E8" modified="2016-10-05" version="1">MIRQSLKFRKTITIVCVLSLLVFIILILKKDKYIDNSELKSHHQRIDDDFQDIGYREFDEIPKKESYVLGEKKIKMEMNNLADEGTKRELQEAKAKIEQLEKKIAILEGRIPQKYPDVQYLGYKERKRILVTGGAGFVGSHLVDVLMIQGHEVIVVDNFFTGRKRNVEHWFGHQFAVIIKNLVPGCRSTVATGAAVEDDPQRRRPDITLAEKHLHWSPKVSLQDGLQRTIDYFKEELSRTTFHNNQTYIDFKVKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R894</accession>
    <name>A0A194R894_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R894"/>
    <dbReference type="FunCoup" id="A0A194R894">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R894"/>
    <dbReference type="KEGG" id="pmac:106712450"/>
    <dbReference type="InParanoid" id="A0A194R894"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003317">
        <property type="entry name" value="Zinc finger protein 322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001573">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF390">
        <property type="entry name" value="ZINC FINGER PROTEIN 37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="538" mass="60578" checksum="472E3AEDA24426D1" modified="2016-10-05" version="1">MSADAASLPCPICLHTGVFNSAQALKDRLIYVSTNNIMCPICQESLSGLDKLTIHLFSHVSFLSSQGSLGNGEKTETKSEAKQGNQIPPTTLKKTRTAPSKNKALASPAPVKFVKIYPKLPVIALNTVPLIDIQSSVDGCIQNNNPMYIPPVKAETATVKTDHKCNVCGLRFIDSNILKMHKCLLHNLDDKSDNTFSSYNCHLCPKTFKMRGSLMVHLRVAHYGFPSQSTTTKKLKEKTGKGEIECKPTTLDRSDGKQWQCDVCRKSFTTKYFLKKHKRLHTGETPYACTQCNKTFTFQQSYHKHLLYHNDEKPHVCNYCNRAFKELSTLHNHQRIHTGEKPFSCETCGKCFRQRVSYLVHRRIHTGAMPYKCTACKKSFRYKVSQRTHKCQAQPPGTVVRQSGELVEKLKKKYVNDPVSKTTNEGNCNNLNYIEISEANAELVRTGAKLSLEDIESDGFSIIAEAFTETNRGCDVISDPDYSTRRNDSNATEYNNYEMFGDDLEDLIDSVPINDKNIPSPSDILKNLCLTNDDDYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R924</accession>
    <name>A0A194R924_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R924"/>
    <dbReference type="FunCoup" id="A0A194R924">
        <property type="interactions" value="1200"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194R924"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="280" mass="31601" checksum="E07B7CEA9039A3DE" modified="2016-10-05" version="1">MGRKIPAKKHRGVKDPLIQQAKRLQELKGKINAPPNDPDDQPVPKSLTRLFAFEHRLKEKSMNLKRKKKIYPKDRDNNKSQNDNPVAKLRKLPGETGRSFTMRINSAMKAIHTPVEQENYPLDIEAEDRKGEQMALQRARRKRKQNKATAAAGEEPTPKLSRTQKLALKKKAKKEKASERGDGDGDGDGEVRRERVAFGEVAHAPPALSVRPRHAAGRTDRRPGCKELLLSAMLSGARGALPPAEAERRERARLEAVAAYRALRARPRPQPLDPRGRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9A2</accession>
    <name>A0A194R9A2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5 reductase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_08654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9A2"/>
    <dbReference type="FunCoup" id="A0A194R9A2">
        <property type="interactions" value="1362"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9A2"/>
    <dbReference type="InParanoid" id="A0A194R9A2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="561" mass="62511" checksum="5673DBCB0B96812B" modified="2016-10-05" version="1">MDWIRLGNSGKDLTGVGGRMRPVHPSELATHNTKNDAWLAIRGRVYNITHYLPYHPGGPEELMRGAGIDATELFDKVHPWVNYDSLLAKCLIGPLRFDRPDAEDLFDNISSSPKSERLREPSKAQELVRKSMENLANCITPVRKKISNKSDENVKSSPPSKIMQSLIHSSDLPVTISRRAASSPVKSETKSNDDSPPALRFDWIQTSTKLTISVYTGYLANPGACARLIDGELLIEVVTDDWLRTIKILPEQALREPLQLRVFAESGKIEVIAQKAEMKVWKNCGETSLSNAVKMTAARTVECRVEGSSAVTHDTVLLALTPRSGPVVIPIGYHVRIHQTLAGSECIRSYTPVGDNWAAVDVTAPLKLAIKRYELGVLSPMLTSLKIGSHVTVSGPYGNFKLQKLKTVRKLFLIAAGTGITPMLGLLKFMLSRSNPRCERVTLIFFNKTERDILFRENFEDIMNQDDRLTVTHVLSNAGPTWAGRRGRITKELLSEAFDESAFISDDELLSYACLCGPTEFTHTGVDILKKLGIKEKCIRILSIICIFTNNIHKRIISRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RA76</accession>
    <name>A0A194RA76_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Follistatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460436">
        <property type="protein sequence ID" value="KPJ14743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RA76"/>
    <dbReference type="FunCoup" id="A0A194RA76">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RA76"/>
    <dbReference type="InParanoid" id="A0A194RA76"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF29">
        <property type="entry name" value="FOLLISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21333">
        <property type="entry name" value="FST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="153"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="300" mass="30955" checksum="14B6AF85A2B26D38" modified="2016-10-05" version="1">MERGGRCSSVAALRVGRAECCSGAARAPAAWSPRDLDSGQIFFYKALSGGVPCTACDESCSGVRCSAGRRCVVREGRARCVCAAACRRAGPVCGTDGRTYRSLCRLRRRACRRPAKHLALDYPGPCQVGTCEGVRCGGDKRCVLDAELGAHCARCGACSAAGAPVCAVDGRTYAGACALRRAACERGRALPLAYRGSCIANATCTSIRCGSGQRCVSGGASGARCVSCGACGAGGGAGGTRRTLCGTDKRTYPSWCRLQRAACHAGTVVDTLHRGPCKGNRNITDNSVTNERHGVDLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAF0</accession>
    <name>A0A194RAF0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAF0"/>
    <dbReference type="STRING" id="76193.A0A194RAF0"/>
    <dbReference type="InParanoid" id="A0A194RAF0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="19399" checksum="885C74CFDA27C703" modified="2016-10-05" version="1">MEDLLQSQIKDSCKLALPEGLRDLMCDISREVLRARPQNLYQFIADYLSAMLVARETLTIAGHVCKGVCNCGCEPELDDELGNIGLTQEEVEEAKKIIIQYLEKDKDKKQVHIDFNETEKIHLKNEIDEEIVNDGKFEEFGDEYDNIDDEVLYADDESDISITEDIHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCI8</accession>
    <name>A0A194RCI8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCI8"/>
    <dbReference type="KEGG" id="pmac:106712237"/>
    <dbReference type="InParanoid" id="A0A194RCI8"/>
    <dbReference type="OrthoDB" id="7468684at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="294" mass="32817" checksum="91220E493C990068" modified="2016-10-05" version="1">MEEIVDDNNKLIEENIDTDLTEFSYNFIDIPWDDRTQRSKILVVLLLLSIFIATMALVVNNFVAHYNSFRHNDSYKNDDINCNLVKVDEYPYAARIQSLTSQQLICVGAVISENSVLANEVCLKSGTVRLFVGSITDQYCKKGFSLDAAELIPHDGVVSKNLVLLSTNKKMSLCGNPIRIAGNMEKDSHAFVIGRPLRGDRSLSRQLVSLDVPDNYTHNGQLIDNSRRNNVICVKYLSRCPVRAGDLLVQGGRLYGIASTSIQRSANNEVVCFANVSIIKTKLKELDDSLNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCV4</accession>
    <name>A0A194RCV4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab GTPase-binding effector protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCV4"/>
    <dbReference type="STRING" id="76193.A0A194RCV4"/>
    <dbReference type="InParanoid" id="A0A194RCV4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15739">
        <property type="entry name" value="FYVE_RABE_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000005">
        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="362" mass="40775" checksum="C4636565EF22A1CE" modified="2016-10-05" version="1">MCANYERQLVSEQGRADAARDKAKQLEQALKLATEELEGVRSLHEETLRAAAGWRAEGGAQLAALAERLAAATAALEERQAAAAAAEQRALHTVTTLTVDRETLQRKLDALERDNAMLVGQYMKKAEDMQNEIIDLPDNVEELQEQQLRLREQLIVCEVGREEAVAAERDLRAQLLHHGALLHRQEEALAATREQLKAAKEELDRLQTERQQMQQLADKLRHSNDMIEQLLEDKKRLQNEVCEVRGRVHALQLELDNSEKVQQDFVRLSQSLQVQLERIREADTEVRWQHDEDVSECPACHTALPNNKKKVHCRHCGRIFCGACVSHTVASGPRGAPARVCGVCRTLLQPHAAPYFSTEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD71</accession>
    <name>A0A194RD71_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD71"/>
    <dbReference type="STRING" id="76193.A0A194RD71"/>
    <dbReference type="InParanoid" id="A0A194RD71"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="149" mass="16204" checksum="DFF8A6D2DBFBE38B" modified="2016-10-05" version="1">MMRSRKGQAASEQDIYREKAFSSRSNVTGSRLRVRRGSSLTDLDKLRYGAGSSGGGSIGDLMNMFSGSATSIGSDSLVARTMPLETVRRSIPPVSTPPPHPPPSPLIHMSRPVGSLTMAQRTLRFSRLLKYQPCSTDVIIILVSYTLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REE3</accession>
    <name>A0A194REE3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vanin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REE3"/>
    <dbReference type="FunCoup" id="A0A194REE3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REE3"/>
    <dbReference type="InParanoid" id="A0A194REE3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="551" mass="62577" checksum="C373B5CF46CCE0EE" modified="2016-10-05" version="1">MDTAKVDLYLCYMFSWHQTTWSEHRQFYTGVRAKSTPQDDSYIAAVVEYEVNTNVSTNVHNYINLIKEAAEKNADIIVFPEMTLTRGQRRILIPFHGILKTYPIPALNPDLYDEILVSMSATAREHQIYVVINVQEVMDCNDAPDEYCPEKKEYLFNTNVVFDRNGAVIDRYRKINLFGEFTRTPALKPELGVFSTDFGVRFGHYICFDLMFQVPAVQVVQKYNITDVIFTTMWFSEMPYLTAVEIQEAYTYAMNVNFLAAGANNVRVGSAGSGIYSGKAGSLISIMPGVPTTRLLVAKVPKVPGEIKEDYPGPIRDDPKALDSLVLISDPSLPSHTSRPLVSGSQEFTLTTNEVSCKFTVKLQLKDGEQGPRYMALAKDGINTYSRKDLGVANCAVVACKNDSIKSCPYRFDMTQDNVVIEDLVIEMTSRVHHYNTSLQCDDIVYFPISFTNNKFPVRPKNFTFLESSKISSNKVLSSCENNLSKDFNGHKEHIIYKLNAPQTDLVSFGVWGRVYNRDVDHNKKPTDDDLKNYLEIEDWIYKKEKKENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REG8</accession>
    <name>A0A194REG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_10028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REG8"/>
    <dbReference type="STRING" id="76193.A0A194REG8"/>
    <dbReference type="InParanoid" id="A0A194REG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="427" mass="49883" checksum="59FF728CD87B5022" modified="2016-10-05" version="1">MFKRSRRLSLVDQFIDGLLSKEAYETPSDTVKEDDLEMNLPEWFDEHLYNRGRSFFWRFCFGLSGSMTSGLISVFSVPTILEVLVGSRRSSSKYTAFKRYLSTFLHVMSWFRYDLKPGTVSWRSLYEVRRRHLKSGRAARLKNKGTVSQRDLALTQFGFLGYAVLKPDRIGVNQQEADDWEAYNHLWRVIGHMLGIKDRYNICRKNIEETREVCRLILDRVYTPCLENVPEYFEHMARVMMDGMWAVNGTMESGSQMYLTKNLANVPGYILTEAERIDLQRRIKEKLNGKHPDIGVDASLLVEKARVEGLPERPPRLLYLKDYDTLDNAPEYKKLPLAAKYKLALFSIFIAFYNTYIGRVLINSYFVLSINLTEYFPYVAFFVYGIKNSYVNIFKESPLDDTPAKPNSEYNKPQQPMPWYKAILAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RF50</accession>
    <name>A0A194RF50_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_08217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RF50"/>
    <dbReference type="FunCoup" id="A0A194RF50">
        <property type="interactions" value="1234"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RF50"/>
    <dbReference type="InParanoid" id="A0A194RF50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265153" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="17"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="349" mass="41058" checksum="816565938AA3C7A4" modified="2016-10-05" version="1">MKTTLFVVLAISAVFAGVPSPEETKRLMDHLSDQEHFRNEHHNKQFDHDAFLGEDQAKSFDQLPPEESKRRLGIIVDKIDSDNDGFVTLVELKDWIRYTQKRYIEEDVERHWKQHNPDNDELLPWEAYRKNVYGFMDEMDERELKSPNSEGFTYSNLLKRDRRRWHYADGDQDDALNRTEFAYFLHPEDHSGMRDVVVLETMEDIDKDNDGKVSLEEYIGDMYKPEDGDEEDEPDWDGKVSLEEYIGDMYKPEDGDEEDEPDWVKQEREQFTGYRDTNKDGFMDETEVKDWIAPPEFDHAEAEARHLVFEADGDADEKLTKAEILDKYDLFVGSQATDFGEALARHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGA7</accession>
    <name>A0A194RGA7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGA7"/>
    <dbReference type="FunCoup" id="A0A194RGA7">
        <property type="interactions" value="2004"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGA7"/>
    <dbReference type="KEGG" id="pmac:106708711"/>
    <dbReference type="InParanoid" id="A0A194RGA7"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="178"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="386" mass="43902" checksum="0227E5E23EBFE142" modified="2016-10-05" version="1">MQGPAIFMDISLEDQAQELRKYFKSLGAEISEEKSPKGIEDDLHKIVGVCDVCLKETNENEIEAILNSIVSIMVSIPLERGENLIVAFSQRLGKSPGPKVGLIALQSLWRLYNNLEANSPLRYHVYYHVIELAARVGAVKDVFSGVEHLKKEFSSCPPSNEQMQKLYRLLHQVLKDHNSELASKVMIELLGTYTDENASYAREDAIKCIVTALADPNTFLLDPLLSLKPVRFLEGELIYDLLTIFVSEKLSSYLTFYENHKEFVQSQGLNHEQNVKKMRILSFMQMAESNPEITFDEMITELQIDEKNVEAFIIEVLKTKLVRARMDQAARTVRVTSTMHRTFGPAQWQQLRSVLLAWRANVHQAHESMKSVAAAQLEYTAQQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGR6</accession>
    <name>A0A194RGR6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Orexin receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGR6"/>
    <dbReference type="InParanoid" id="A0A194RGR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="297" mass="33528" checksum="8E419CF44F04005F" modified="2016-10-05" version="1">MNSINYVTSRVVNAWPIENSTKDFSLNEEFRNSTIDDDADVFIEDEYIFDRTDLVILGVWITSAAYSAPKFIWVETITNNLGDGHTETICIQHRMKYNSEIFDMVNFVLLYVIPLCIMTVLYTRIAVGLWQSSHGLQQMGHTQCCGAQKNASATNKGGSSKKTSQNQEGRNCYHLSHLSRNVLRARRGVVRMLIVVVLTFAVCNLPFHARKMWQYWSSGYQGTSDFSALLTPLTFLITYFNSGINPLLYAFLSKNFRKAPITEKVNTFAATHARVWSTVSMLGAVHAPVRSLVVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGR9</accession>
    <name>A0A194RGR9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGR9"/>
    <dbReference type="FunCoup" id="A0A194RGR9">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGR9"/>
    <dbReference type="KEGG" id="pmac:106708927"/>
    <dbReference type="InParanoid" id="A0A194RGR9"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05244">
        <property type="entry name" value="BVR-B_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="204" mass="22545" checksum="F6CA8DF6474678A0" modified="2016-10-05" version="1">MKKIVIFGSTGMTGLCAVEAALKKGLQVRAFLRDPERLTDNLKDKVEIFKGDVLEPDSVANAVEGTDGVVVALGTRSCLDPTSDLSEGLKNILEAMRAKNVKTISTCLSAFLFYEPDKVPQKFQHLTDDHRRMYEALKETSMNWVAVFPPHISEEPSCETIIQVNPQKSPGRAISKWNLGEFLVNALTEPKYYGNVVSLCDAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGW8</accession>
    <name>A0A194RGW8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_09203</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGW8"/>
    <dbReference type="FunCoup" id="A0A194RGW8">
        <property type="interactions" value="1730"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RGW8"/>
    <dbReference type="InParanoid" id="A0A194RGW8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="5"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="943" mass="104733" checksum="A3A3D443FC850989" modified="2016-10-05" version="1">MDTSLTGNQIRKTFIDFFIGKGHKYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGSVDPNSDMAQYVRVVNTQKCIRAGGKHNDLDDVGKDVYHHTFFEMMGNWSFGDYFKKEICAWAWELLTEVYKLSADRLYVTYFGGDAASGLEPDLECKNIWLNLGLPESHILPGSMKDNFWEMGETGPCGPCSELHYDRIGDRNAAHLVNMDDPDVLEIWNLVFIQFNREADSSLKPLPKKHIDCGLGLERLVSVIQNKKANYDTDFFMPLFKAIETGTKTRPYTGKVGADDVDGIDMAYRVLADHARTLTIALADGGCPDNTGRGYVLRRILRRAVRYASEKLNGKPGFFGSLVHTVVELLGDVFPEIKKDPESIIQTINEEEIQFLKTLSRGRNLLNRTIEKLSGSKIIPGDVAWRLYDTYGFPVDLTHLMCEEKGLSIDMEAYEKAKKESQLNSQGKAAGQEDLLALDIHAINHLQESGVPVTDDSPKYSYTPSSNDKDAIYSFAPCTATVLALRWNKEFGGQIFDEGYMVKIDDDSVEFTVKNVQVKGGYVLHAGKVEGTLKVGDKVSLHIDTERRRLVMNNHTGTHILNNVLRKVLGNDSDQRGSLVMPDRLRFDFTNKGPMTVKQIKDAEDEIKNIIAENKAVYAKHTSLADAKKIKGLRAMFDEHYPDPVRVVSVGIPVEELEKNPDGPSGYETSVEFCGGSHLHQTGHIGDYVIVSEEGIAKGIRRIVALTGPEAVKALNKLSVLENEVNNIANFIKEQGDAVNHKEVVKKIVELTNDVSHAQISYWKKEELRNMLKGLKKQLDDKERASKAMIITQVIEKTKELCLEEKDSDVIVTELKALGNTKALDGALKQVKQILPNTAAMFFSVDDETNKIYCLAAVPKTLNEKGLLASEWVQSIVSVMGGKGGGKAESAQASGNNPKSITEAIKIAKEFASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH50</accession>
    <name>A0A194RH50_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KQ460397">
        <property type="protein sequence ID" value="KPJ15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH50"/>
    <dbReference type="STRING" id="76193.A0A194RH50"/>
    <dbReference type="InParanoid" id="A0A194RH50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="141"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="420" mass="45959" checksum="BF67E53F7926FDDB" modified="2016-10-05" version="1">MKVTICGAAGNTGQPLALLLKQSPLLDEIALYDICPTCGYGMELSHVDTKCKISSFSGRHMLCDALKDAKVVVIVARDEEDSFEKSAPIITEIALQICNTCPETFTIVGTEPVESMVPLISEIQRLRNVYNPRKLLGCVELHCVRANTVLADFLRVPPESVRVPVIGGATPNTMVPVLSSAVHPGTLTQEHVECVTSCIMGGTEAVCAAKGCKHATASLAGAYALARNTLNVVKGLQGGKVEQCAYVDCLGTCAPNCQFFASEVILGSTGIEKNLGIPELTKFENCLLCKCLPYVQNEIARAIWLVYTMCQQCTCYCSPSPSECYAPPCMPCAPPTNWTCECPDSCRDEYLASICREMTCRCGNTELCWKPREFDFYTDRATKGRQRMMEHSAACNDCRMPKSVRIEQEIRNRAKTPRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH51</accession>
    <name>A0A194RH51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmatocyte-spreading peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GBP/PSP1/paralytic peptide family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH51"/>
    <dbReference type="KEGG" id="pmac:106708692"/>
    <dbReference type="InParanoid" id="A0A194RH51"/>
    <dbReference type="OMA" id="AHKVRDD"/>
    <dbReference type="OrthoDB" id="7439590at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003463">
        <property type="entry name" value="GBP_PSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02425">
        <property type="entry name" value="GBP_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265209" evidence="3">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="13994" checksum="1731AB6595BACA33" modified="2016-10-05" version="1">MKLSLIVLLCVGIVVISPESNGDVVVDLFGKIQESAQKIGDDIKNVFQSNNKQNNQYPRESVKVSKPDSRDADRIVFDRSEVTQASVTTPKGVSNNTKADPQAGRENFRGACATGYERTSDGRCKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHN1</accession>
    <name>A0A194RHN1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHN1"/>
    <dbReference type="InParanoid" id="A0A194RHN1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="692" mass="78729" checksum="F342A062390F135C" modified="2016-10-05" version="1">MVPPPEYAGQPVRLPPDSRREFRCKRAEGDSPSLVNNVRLIEPIPYMINVISETVQRLEDAEWCSLKVPDVTVGLKLRSNIRCESVKGTVAYRNGFVAAIQHVNILEHSLGQVWRYDRVQNTTTVEVTGTLRFADVTVGFDVETRIEGTIKLYTAELLVPLVTFDMRVIRDMFTENVNVTVVPLAITRNRVKMDFMPVDDLTDVLSNLFNFTSISEAANIWASDFLRPFALNAVENVVDYPEICYDCPVLYCEKSTPKISEERLHDNLTTMNGTALNNVRLIEPIPYMINVISKTVQRLEDAEWCSLKVPDVTVDLKLSVKGTVAYRNGFVAAIQHVNILEHSLGQVWRYDRVQNTTTVEVTGTLRFADVTVGFDVETRIEGTVKLYTAELLVPLVPFDMRVIRDMFTENVNVTVVPLAITRNRVKMDFMPVDDLTDVLSNLFNFTSISEAANIWASDFLRPFALNAVENVVDYPEICYDSRSPSLVGGYEYYLNAMQELVFELEKYGWWNLKMLDVTQTLNEHMYNWHVSGTVNYTNGFVISIEEIDLSDITTVMTSRTVNNTLEWNGSVRGHVNLRDVRVGFDVIVNLDGQPEQRYTGVFTHSLIRIRCTMNKNMNDKKKTVSAETANLNAGRGVRMIYLPANHVTQVLSRRYLPHDNWDSVSSWCRDVIQPTLQKVAEKIQYPSVCFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHN6</accession>
    <name>A0A194RHN6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc carboxypeptidase A 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_13933</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194RHN6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RHN6"/>
    <dbReference type="KEGG" id="pmac:106708634"/>
    <dbReference type="InParanoid" id="A0A194RHN6"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
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        <property type="entry name" value="M14A-like_propep"/>
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        <property type="entry name" value="M14A_act_pep"/>
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        <property type="entry name" value="Peptidase_M14"/>
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        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
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        <property type="entry name" value="Propep_M14"/>
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    </dbReference>
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        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
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        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
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    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
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            <begin position="1"/>
            <end position="17"/>
        </location>
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            <begin position="18"/>
            <end position="458"/>
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            <begin position="432"/>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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            <dbReference type="EMBL" id="KPJ17077.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="458" mass="51681" checksum="5EB5CDE2D534B1A0" modified="2016-10-05" version="1">MRLSYLLILSGCVLVSSYKSYENYKVYNIVPTTDSHVQILSDLRKVGYEYWTDVIAIGSTVRIMVPPNKDDDFLGYCKIVGLNPAVSISNVQKLIDDQLKPHGQIDRSNSLGSLSWTRYHTLQEIHTWLDELAERYPNIVTPATIGFSTERREIKGIIIDFKPGQRGNKPLIGMIEGGIHSREWISPATVTWIIKEFLTSTNTEVKNLAEAFVWHIFPVVNPDGYVYTFSDDRMWRKNRNPVNYVNCTNVANDLSNGIDLNRNFNFLWMTTGASSDPCMQTFAGPSAGSESETQAISNYVLTLKQTGNFIYYFAFHSYSQMILVPYSHASGSQVLEAENYADMFEIAIRGSDKLTERYGTRYTVGTSADILYEVSGSSFDWVKGVAKIPIVYLFELRDVGEYGFLLPAEQIIPNNEEIVDCLLEMDRTTRRIGYYSSAGSMTSSIIIVLISTAILILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJD7</accession>
    <name>A0A194RJD7_PAPMA</name>
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        <recommendedName>
            <fullName evidence="4">Rho GTPase-activating protein 20</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">RR48_07340</name>
    </gene>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Ya'a_city_454_Pm</strain>
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        </source>
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        </location>
    </feature>
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            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32832" checksum="63B0632687549DC0" modified="2016-10-05" version="1">MTSEALGVSVAPSFFHSCVSDGKTATMEDVQRFKVATRIMRQLIEQFSAGDLFGRENYEFYARVTGRILRVKDEWICSFRDPPPPRHHRDQEAYARQLSLEAEKTWLQCECDRWGNKFNLEGLSKSEECQSMPTLASAGGAGAAGGALGLGIIPEHSLLDSCTRLSISLEESVFKVSVSSSSQSSCSNSSPHMTLDELRAINKYAESTKSLSYLPQVHERQRARMRTRSEWFLQPAASLDAGRSRAGTPLEPRPAPTRATPRAPPRAPPTAPPTACAGEARDESTALYLLVACLEFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A194RJP6_PAPMA</name>
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        <name evidence="2" type="ORF">RR48_11901</name>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJP6"/>
    <dbReference type="KEGG" id="pmac:106721490"/>
    <dbReference type="InParanoid" id="A0A194RJP6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="938" mass="106280" checksum="502D665C5FA60F8E" modified="2016-10-05" version="1">MPPKSKRIKNITTSKENTILATKAIQKSVVKNAKVPRKALADKTNSASDDNDPVTSPKIRIQTRKMKAINVNTAKLKENDKIRPKRNEKLRDISTKNQVLNIKSNKPIEPETHTVLQKTPVAILEPMQQVSEKVVEKRIADSRPKRICRLPSKFDDHFISPSKCIPVQPIQASTPIVQIKDKKISAKFDDEINKSFTKKNQQTISTDSSKGSSSIENSSSSYNSSTEKPKRNTRSTKRKLIKPVLEKQKASKKIPNTNKKQADTNNNAKDTNPKQSFCNTSPCKDVNKITKNRIIKKDYSFRLFDEKKDAKKRSANNLDVYEFTYDPAQEPPPPKKKRKRVVKKNQEKPKHVLKTNYDKNIAKSLADLKNMLSKKTDAKQQTETPVPSQTKFTPSVDNKIKNVPQNTNNAVTENVPLNTNNAVTENLPQNTNNAVTGNVLQNTNNAVTENVLQNTNNTLAKNVPQNVTHTVENGLQANFNSFNVEDIVLNDVSIANDYNDLNYSPVNSPDHVRQASEPRDVCAMETVTNNDPLNIQEDISFFDDIPVASSSMNVSTRNPSATPWRAEYEQLPIKWQVNTYVKPNMTPAFECSFINFNDKKKHVYTNMVPEDPEPLQEIIETETPSKLKQTSIISFFKEVVERQTRKKLKTKTTPVKDPVFDDHNTDVLPTEEPVASNSIHKTPQKTSSKRSTDLSDNKENSTELVQNSPTKSRTKKSRQNEVNKDVTFFGFDESEEQENVSPIKKDKGKINALRPRSRAVLQEFNVQKGPIRMPLGARNKKDRNAINKVFDEVVDIEENLFQEKAKEITEETNNSVESNVNISPEDSQSVHLFEDLEVVHSKPPRKSYGKAKKVAFRHHSESSDTQEEVQGNQGGSSGEEDNLEDLTFEIPTAQTKRIRKKKKMAKQRSRKEDKEAEEWAAGFNSMCEDIDHFDLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL18</accession>
    <name>A0A194RL18_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL18"/>
    <dbReference type="STRING" id="76193.A0A194RL18"/>
    <dbReference type="InParanoid" id="A0A194RL18"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="30978" checksum="3449263CF53484BB" modified="2016-10-05" version="1">MGAQHLCCKGFCTKGVHRAAAVRTSGEPSSSVVELSSSTSSTRTTTTTTTTTTTTPSTTTTSSTTTTTTPAPTTTTTTTTEPPRPFFQLLPIQNPSTPAPAAHAKVGKTQKFVCPKKAAPVVLFPIPCETNSQCRASSGADQVCCQGRCLKGDPAPRPTVQQSHQPLLGVIPRECPAAPLGELLFDVQSCKSDADCWPRVCCPDGTRSYCRTARARLDLVPVANAIDAPLRSFEQYLQCTAPPQHDPFPQRCSSSVDCFPNLCCAEGGKKHCRPPQRSLFSLLAGVTQVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL40</accession>
    <name>A0A194RL40_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_11888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL40"/>
    <dbReference type="FunCoup" id="A0A194RL40">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL40"/>
    <dbReference type="InParanoid" id="A0A194RL40"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="271"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="334" mass="36379" checksum="06FB5EBDF442733E" modified="2016-10-05" version="1">MTATASAVTASVDEDLDDCGPQLINKLEGNGITSGDIKKLEEAGYHTVESVAYAPKKWLITIKGISEAKADKILLEASKLVPMGFTTATEFHQKRAEIIQLTTGSKELDRLLGGGIETGSITEIFGEFRTGKTQLCHTLALPIEQSGGEGKCMYIDTEGTFRPERLLAVAQRYGMEGAAVLDNVAYARAYNTDHQTQLLVQACAMMAESRYSLLIVDSATSLYRTDYSGRGELNSRQLHLGRFMRMLLRLADEFGVAVIITNQVVAQVDAVAVFNADTKKPIGGHIIAHASTTRLYLRKGRGDNRVCKIYDSPCLPETEAMFAISTEGITDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLH7</accession>
    <name>A0A194RLH7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Intron-binding protein aquarius</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLH7"/>
    <dbReference type="FunCoup" id="A0A194RLH7">
        <property type="interactions" value="1786"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLH7"/>
    <dbReference type="InParanoid" id="A0A194RLH7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="5">
        <location>
            <begin position="194"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="6">
        <location>
            <begin position="406"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="501"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="809"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="950"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1194" mass="136935" checksum="730D8B4A94D8E67B" modified="2016-10-05" version="1">MLKFYARFEISDETGDPMTDRDMTLQHYSRITSLQKAAFSKFPDLRLFSLANVASVDTRESLQKHFGNLSDKALRAIATYLNLVPPEGKEDEAPWHRLDKEFLKELLISRHERRISQLEELNSMPLYPTEDVIWDENVVPTEIFSGENCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVYRLAPWRAEDGSVYFGGWARMAHPIKSFAVVEVAKPNIGEKAPSRVRADVTVTLSVRNEIKQEWENLRKHDVCFLVTVRPTQGIGTKYDYRRSMVDQAGIVYVRGCEVEGMLDASGRVIEEGPEPRPELDGDSRTFRLLLDPNQYRMDLDRASKGKEDVYETFNIVMRRKPKENNFKAVLETIRELMNTECVVPDWLHDIVLGYGDPGQAHYTRMPNEIPTLDFNDTFLDMDHLRNSFPGYEIKVQVDDPRKLVRPFKVTFENVLRKEKLGENAMDEDDSHKVIVVEPHVQPKRGPYLYNEPKKNNILFTPTQVEAIRSGMQPGLTLVVGPPGTGKTDVAVQIISNLYHNFPWQRTLVVTHSNQALNQLFEKVAALDVDERHLLRLGHGEEALHTDKDFSRYGRVNYVLAKRLELLQQAARLQRALRAGGEAGATCELAHHFYVYHVRPRWDDFLLLLAHDKTKSVETISKEFPFHEFFEDAPKPLFPGKSYDEDMEIARSCFRYIDHIFEELEEFRAFELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRSELVQMGFKYDNILMEESAQILEIETFIPLLLQNPQDGRSRLKRWIMIGDHHQLPPVVKNMAFQKYCNMEQSLFTRMVRLGVPYVELDAQGRARPSICNLYRWRYRALGDLGHVLRLPEYRAANAGLRHDFQLIDVADFNGAGETEPSPYFYQNLAEAEYVVAVFMYMRLVGWPADRISILTTYNGQKHLIRDVVDKRCAGNPLIGRPHKNLAEAEYVVAVFMYMRLVGWPADRISILTTYNGQKHLIRDVVDKRCAGNPLIGRPHKVTTVDKYQGQQNDVALVSLVRTRAVGHVRDLRRLVVAASRARLGLYIFARADLFRNCFELQPTFNQLVERPLQLELVPGETFPAQRGAEAVVPAARVLRVHDMPHMARYVYDMYLDIVRLRTGHQQAEGGWVPPGSESAARPRSPRPPTTTPSAATAATAADSDDEDTAPTFTPTNIVNEVEDVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLJ6</accession>
    <name>A0A194RLJ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitogen-activated protein kinase kinase kinase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_10652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLJ6"/>
    <dbReference type="STRING" id="76193.A0A194RLJ6"/>
    <dbReference type="InParanoid" id="A0A194RLJ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="210" mass="23477" checksum="3DA3598B67899BE9" modified="2016-10-05" version="1">MPPLPAPPARPRHRDPHVPLAPHTAGIVTTIRDTGRPPPSCAHNPRDNLVTTSSPLQQAKQAPRLCCGLRHPCPVCASASDISNSSGSTPAEGAAQPAPDPDLDSMHMMLDPHLRPISPDLSNEESKRIFEEHKQLAQEYLKTQTELAYLSNHKSELEEQMDSDELRQKREVIQLENEKDSLLKLYCTLKKQLARAENESWLLQEDMPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLT8</accession>
    <name>A0A194RLT8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLT8"/>
    <dbReference type="FunCoup" id="A0A194RLT8">
        <property type="interactions" value="1477"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLT8"/>
    <dbReference type="InParanoid" id="A0A194RLT8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059188">
        <property type="entry name" value="Znf_CLPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="6">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1019" mass="109345" checksum="78D1661C7AE998ED" modified="2016-10-05" version="1">MSSIRLSFVSVGRIAVRRNSHLTSGGVQTCRAVRRACLRPLTTCSVLCKNPGEQPPGAAGTPHGPPKDTATGGVQTCRAMRRACLRPLTTCSVLCKNPGEQPPGAAGTPHGPPKDTAAGQSSGGKKSGSGTGGVLTCPKCGDPCTHVETFVSSTRFVKCDKCHHFFVVLSEVDTKKSIKDNADNKSGFYRKPPPPPKKIFEYLNKHVVGQEYAKKVLSVAVYNHYKRIYNNVSSGAHADAHHPLHHTHRELLHVSHGGGGGGAGGGGGAEVLDRQQHELRLDKSNVLLLGPTGSGKTLLAQTIAQCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANFNVERAQTGIVFLDEMDKIGAVPGIHQLRDVGGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCRAGEGVQQGMLKMLEGAVVSVQDVECSVCWCCRCQGVQQGMLKMLEGAVVSVQDVNCTCMFGVAAGEGVQQGMLKMLEGAVVSVPERNSRKLRGDAVHVDTTNILFVASGAYNGLDRLVQRRSNEKYLGFGAWDRSGGRRAALAAADTTNILFVASGAYNGLDRLVQRRSNEKYLGFGAWDRSGGRRAALAAAAADASPLQSAAAEGDERDAWLRKVQARDLIDFGMIPEFVGRFPVLVPFHSLNQDLLVRILTEPKNAMVAQYKLLFAMDKCELSFSEEALRAVAALAMERKTGARGLRAIMENLLLEVMFEIPGSDIVSVHIHEGCVRHSEPPSVTRRQPPHERDLHDWPSVRLHNCTYLTPPTPPSPLRDQRSVCSLSDTKPGDEESELSEPCVSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN40</accession>
    <name>A0A194RN40_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coronin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN40"/>
    <dbReference type="STRING" id="76193.A0A194RN40"/>
    <dbReference type="InParanoid" id="A0A194RN40"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="3">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="292" mass="32910" checksum="C4C002389F256A61" modified="2016-10-05" version="1">MPPVKDETIREINCLDINIVEKSPAKNSALVDVRACNKPAAKVWFRGVRSSKFRHVYGVSFKRERCYDNIKITRNAHDSNCCPVNPKFVTFMPNFIEITGRLDFNASRVTGHKGPVLDIKWNPFNDNVIASCSDDCTVYLAGKGDGNIRYYEVVDEAPYVHFLNQFLSGNPQVYLAGKGDGNIRYYEVVDEAPYVHFLNQFLSGNPQRGLGYMPKRGVNTAACEVFRFYKLHTSRGLCEPISMIVPRKSDCFQEDLYPDTAAPLPALSAKDWLSGMNAPPLLISMKNWSPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN82</accession>
    <name>A0A194RN82_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN82"/>
    <dbReference type="FunCoup" id="A0A194RN82">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RN82"/>
    <dbReference type="InParanoid" id="A0A194RN82"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF23">
        <property type="entry name" value="GH11223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="3">
        <location>
            <begin position="599"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="800" mass="89957" checksum="31B87B5CB871AFB3" modified="2016-10-05" version="1">MTKAKTKGVRGRIAHEIYTYCAFWIAVSSLPALALSYVVVRVSKHLWIKLLSSRYPHLEFIRTDTIRSLLDTHRNQGIINVLLCIKGKQNVEQIRNELYEHVIERRDKDGGLMFPRLRHCLVSCWGNYAWDAHVPFRPDNHFIVSNAVYRGRPVSDSNIQQIRNELYEHVIERRDKDGGLMFPRLRHCLVSCWGNYAWDAHVPFRPDNHFIVSNAVYRGRPVSDSNIQDYVSEIISKYFPGDQPPWQYIVIPCISPDPKYYILVRVHHMLLSGTNSINIGDLLLIEQLKPEERQITEHAQASPLNKLFPTPKAIPELWEKMNETMSNVWNEFISEYDPVESPRASKTMPGAFHVAGLLLVSAANAVRELKKKKSSEGTEHATTPTSFIRVIRQECKRRNLTMPKLILSPLVTADPRKWPRLTLSAAFSTARALLKLPFTLKDELTAVRELKLTGHVQQTNTITWKYAELAQTLMNATLEAWRCAVEVYRAPAELWSDTVGADEGNRHLLQTVSLCGRKVVSWSRPIPRSFIERSGRALGVSATDVALFAATDAIRAVFDSAQVETPDYVLTSARAAPEEFLFTFAEGEGKEYKKSHTGGMICLSLPIGATPRRIASLVSEACKAQKALSGAWALQARCGALTRSVPSPLARLTLNLLSRRYAVSYAEINAPPDAAPRTTVWGQTVDHVVYWRPPQANISLSLTVIQYSDTVRLAVMADARLSPSHTVPAQRWPVAVEQLITKINTEIARIAAKANISAVELPTDTETKTVSQSYYSEDTLKPPTTESLSPPPTRKCFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNJ3</accession>
    <name>A0A194RNJ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_12495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNJ3"/>
    <dbReference type="InParanoid" id="A0A194RNJ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265324" evidence="9">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ18984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="9902" checksum="BF66522D56B593EF" modified="2016-10-05" version="1">MKLRNTLSLPMLCQLASSGMLICLAGYQVALSEKISNAVYCSNWESGVALVQGVRPRIMFVIARAQKSLALTAGGFFDLSLVTFTTVKTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPF8</accession>
    <name>A0A194RPF8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPF8"/>
    <dbReference type="STRING" id="76193.A0A194RPF8"/>
    <dbReference type="InParanoid" id="A0A194RPF8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119243" checksum="611571FC44F0BD00" modified="2016-10-05" version="1">MFPVWPICLPVNGPNIFFLGPVESIELINIPVLQRDVECHGRIVSSVVRLCGGGDAARALERRWHLLYLRAIEWQCHLEACLAKSDIGCLSIEAASDSDEEPALKQPRLCRGSPRRRTPQPRPRHPSLDSRQSASEEEGEDVLRCEWRDFVPERESARRRRDMDRSDEHRVPDLTHLTDLADLTDLTHHNDVVDGHTPPHSRLNGLSTQETESMNFHEHTKTPPTVVKRKKPVDTSKFNQTDRKSKNCATFYFRHHDTDSDGRQMIETDEKSQESSEEEWTYVGNPKIANEDSTDLMTSSIEIQCELTLDEKKDKPSPKPKLESSTPDLLKVEARCKDIERLVIQAEELVQKQAQHQMAKKKNSRNFKSSLIDEEGKSVSRGKMSRIKEWLNQSTEDERNKNETNQCTESYDASGEYTTESEVDTSLTSEERNLHSSMDMSTSTCTVTPTHQAKPMCYSRPCSYIYAYTVRSVEPFWLSTSTCTVTPTHQAKVQLRKKRCGPRPWSVSCLSQLPARSDIAHNMSISESALNTLASPQRVTPADSNALRGSSTTVQGHVSSTNTMTEACTSCVEAGERQCWVRRKRLKLRKHVADTRHSHVRDRDRLVKSRSFCGRLSPEIEDKNERSAASDPATSRKNRFDTTSTSGNESDEELIKQQLATVAHLRRSIEKTHITAKEDSAIPEQNEPEAVTPSFKLGPEGGPVRPRMARSSEREKSFLALSLGDPSQLWDLSIDKDSDIDKSVTAGTEEHSSFSEQAWDFYQEKYNSEPYSEAPDSDGARRLLEFGDDYRAYLDSQSDCCSSLSAQPERAASPAARRLPRHKRPLRASPLPRLDSPLRKPKKSITTAERKKMLLDTLEKSRNSVESNECRRRKPSDSDRKNKRSPEFDLLNVQALSRRRHSSNITSDEVNSSLEYTEVNNRPDILDSLNRRRKNTDKDAESELQKVALSELRRRSTEGADSEDSSPKKHSRRNWEGDSDSEEEVRSLIRRSGSQLEAAEAAMARHDSSPDLLRAFDYTEIVARCRENINMLDAALADGSVLSSALQRDIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ42</accession>
    <name>A0A194RQ42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ42"/>
    <dbReference type="InParanoid" id="A0A194RQ42"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF125">
        <property type="entry name" value="GH11385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="863" mass="95952" checksum="5DA6592718AEF11E" modified="2016-10-05" version="1">MLFKRIIEGKSMLNSDVKDKSPEKCSRRKSECDGCGEHSTCAGSHANYPVGKNVSAPARERMLAPAGTRRNVGAAVGVMTPACDGADWGGPALSRALLYLMTKSTINYISENLKVILSGVFDDNPIILEEMTKMVLLGVVLWAGVTFGTHVAPYPLNLIVSSDNLHPPPMYDFPFPSAEMLRRIPPVTTAHTNGSVDYSKKIVGMLERYEHNLQAAMVTPKQGSAAQAFAIQGRPSSEAMHYEKSSMIITKASQNLMWRKCSNFGLPNDECASFISTLNLRETEFGPECAALERFTCRTNKMSSKYRTFDGSCNNPVRSSWGQALTGFKRLLHPRYADGIEEPRKSVLPKPLPSARVVSMQLTDNVDKPDDKKTIALAAWSQFLHHDLVHIPVRKTIHTDQPIRCCDVSGYNLAPRHVHPNCMPISVPRDDPIFKEDKNRNAITCMEYTRSVTTYRGDCTFGAAEQMNQATHFLDGSHIYGSNSRDAAALREKTGGLLKTSTIENEEHLPLASSPTDKCLVESDKEACFNTGYNSDIDPTVTNSFATAAFHFVNTLFDQDIEFVDVDNNVVAERLKDNYFKPELITTKGGLEKLLRGMVSQKSQNSDLNYDDDLRHHWLGGLDVLAIDIQRGRDHGLPGYVQYRTLCGLPHATDFQQLSDVIPQQLRHHWLGGLDVLAIDIQRGRDHGLPGYVQYRTLCGLPHATDFQQLSDVIPQQTVDKLSKLYDRAVDIDLVVGMMAETPLPGSLLGTTATCLIKEQLWRTRSGDRYFYTHSEAGGFSKRQLAELRRSSLAALLCDNAGIQRVQRDVFNTPSDSNPVVSCEEIKRVNLEAWQNPSQQPDILTRTNNWLKNKVANAGNTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ66</accession>
    <name>A0A194RQ66_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dosage compensation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ66"/>
    <dbReference type="STRING" id="76193.A0A194RQ66"/>
    <dbReference type="InParanoid" id="A0A194RQ66"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265371" evidence="4">
        <location>
            <begin position="22"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ19632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="645" mass="70623" checksum="39274647115846DA" modified="2016-10-05" version="1">MLEPRLGKMMVLGFVLGVGDALTTMAANSTTFPEIFIVEGRRRLSMHQRALAGDRASDHVAMLNAFQMWERERAKGEDAEMRWCEWKGVQQTTLQVTNEAKMQLTSMYITAQGSCGTSTTRRLLHVVLTSSLRTPRRAPDGGDVPHTATRTGAQKYSKGICWCSIKLLRLGSIGHFLSKAPEPPPVDAVIEAEALLRELGCLDAADALTPLGTILAKLPIEPRLGKMMVLGFVLGVGDALTTMAANSTTFPEIFIVEGRRRLSMHQRALAGDRASDHVAMLNAFQMWERERAKGEDAEMRWCEWKGVQQTTLQVTNEAKMQLTNILTTTIGFPEDCCIPQRWMPYSPDPMLDQVMALLCMGLYPNVCVHQGKRRVLTTEGKSALIHKTSVNCNNLEQRFPSPLFVFGEKVRTRAICCKQTSMVAPLHLLLFACRKVEWIDNVVRLDNWLNFSMSPRTAALVLALRPAIEKLVERAAAEPDAALNFSMTEKKVLHCIKSLCMFDAGDYNIRRDVSTPTFRSDAAKRGTRGWGTNSHRGNFGSAGSGDQGGFGNRGGFGNRGGFGNMGGFGYRGGFGNRGSRGFGNRGGFGNRGGFGNQGNVSYGSDGNGFNNQSGFGNRGGFGNNRFGNNYYGNTGGFQGNDGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQQ0</accession>
    <name>A0A194RQQ0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Baculoviral IAP repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQQ0"/>
    <dbReference type="FunCoup" id="A0A194RQQ0">
        <property type="interactions" value="1829"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RQQ0"/>
    <dbReference type="InParanoid" id="A0A194RQQ0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089720">
        <property type="term" value="F:caspase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022416">
        <property type="term" value="P:chaeta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="670" mass="73700" checksum="4D230128D76A191C" modified="2016-10-05" version="1">MNLEINRLNTFTNWPACALINPVRIAKAGFFYTGQGTEVQCFSCSGKLSQWNCGDQVMWRHRMMYPNCEFVINPQSSGNVPLTPGGDCPSTDEPVAPSESSPQRSNRSSSNDQNIDESSQDYGHTEEDEMYKTDILRLLSFTNWNDSSVSQEALVNAGFYHAGEGRLRCAWCGGELAPFRNFGSLGSPLEVHRMYFPRCAHAQALETAQRNNYAMMPTRPWEDPDVPDNTDNNQPQSSGAAHNARVVAAGSSWRSLGVVGGGARHAAYASLASRLQTFSHWPADRPQVPKALAEAGFYYTGVDDQVRCFYCDGGLGKWEAGDAPWSEHAHWFPHCGYLLLVKGHDFVESCRNKSSVQRTVRCFYCDGGLGKWEAGDAPWSEHAHWFPHCGYLLLVKGHDFVESCRNKSSVQRTLSADSGLSTRRRNPSANFSITDSQVDACMESSTAMAALGAGLDAARVRRALLRRLRTTGLPFSSSEALIDAVLDEQLNEEAWSVTPQSQRLARDILAETLRDFVPGGTRLMPPSRAEDESESRSESESPSASPTPAARNITPFRRRDVTPSRASLPTQPSRSEKTQTRSLSSSKERKTSGDKKRNASPASQKKELTLEEENRQLKEARLCKVCMDSEVSVVFLPCGHLVSCAGCGAALAACPLCRAAVRALVRAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSC0</accession>
    <name>A0A194RSC0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSC0"/>
    <dbReference type="STRING" id="76193.A0A194RSC0"/>
    <dbReference type="InParanoid" id="A0A194RSC0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="118" mass="13392" checksum="3F0207E10D424471" modified="2016-10-05" version="1">MLERYERAADMFAKVTRARRDLAAQLEGQQEPKEFDGATTSQVVSSLCQDANDTWSALQSERARVLQLESAILMQSLQLEREGKVRTQLERRKAMLERQILRLVGPGSQNTLLSDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RTL8</accession>
    <name>A0A194RTL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RTL8"/>
    <dbReference type="InParanoid" id="A0A194RTL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="10147" checksum="7FE89E635FE549E8" modified="2016-10-05" version="1">MIVGDTVHRKMVFHQRVKEFPIPFKKRIKSLSYSDPEKRIIKGVAAIDNDFSHASANITEGGVGYSYVTVRMKSQRHHPLNFEVEIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RV56</accession>
    <name>A0A194RV56_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycogen synthase kinase-3 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_07516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RV56"/>
    <dbReference type="FunCoup" id="A0A194RV56">
        <property type="interactions" value="1093"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RV56"/>
    <dbReference type="InParanoid" id="A0A194RV56"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="57"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="462" mass="51428" checksum="870EED1A10D5C036" modified="2016-10-05" version="1">MLLLCLPRLAGDVDAPKKAELASEKKTATSHRKDGSKVTTVVATPGQGPDRPLEVSYSDMKLIGNGSFGVVYQAKLCDSGELIAIKKVLQDKRFKNRELQIMRRLEHCNIVKLKYFFYSSGEKKDEVYLNLVLEYIPETVYKVARHYSKDEQTIPISFIKLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPKTGVLKLCDFGSAKHLVRGEPNVSYICSRYYRAPELIFGAIDYTTKIDVWSAGCVVAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWAKYMLERMTMPKSATDHQRIRVFRACTPPDAISLVSRLLEYTPGARLSPLQACAHSFFDELREPAARLPNGRALPPLFNFTEYELAIQPSLNEFLKPRSPAAPNDAPGGSGAADHAHDAQGTCTSTRNIYINLRTLLNVNSLTADNAAACGPSGGSPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RW51</accession>
    <name>A0A194RW51_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RW51"/>
    <dbReference type="KEGG" id="pmac:106721270"/>
    <dbReference type="InParanoid" id="A0A194RW51"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="194" mass="22456" checksum="C240EAA83A72EED1" modified="2016-10-05" version="1">MEEIPAIADSFEERRKIFKDIWDSSDSNDSEDHNQKPKVIKTARLSNDVIAIRKKRVKKLKSVCKKVLEISDRKKYIQEEITIIGTRKSKKIKSAFVRRRRKTVKKVKSTSSCKSSSKNLPLMNDVTSEDKNDDDETSRNVPVITQKEDIKENTKKFIKAVKVEGKKSPVRFYLKQPVQVQRELATLTTINLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAM2</accession>
    <name>A0A0N0PAM2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FERM domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461187">
        <property type="protein sequence ID" value="KPJ07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAM2"/>
    <dbReference type="FunCoup" id="A0A0N0PAM2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAM2"/>
    <dbReference type="InParanoid" id="A0A0N0PAM2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="498" mass="54987" checksum="8D35082A4B86167D" modified="2015-12-09" version="1">MFKSRGDSNIVYKCTVRLLEDTEILECEFHPGYKGKYLLEHVCQQLNLAETDYFGLRYVDAAGQRHWLHIAKLILKQVKDGVAVGQNPPNPLLLKEDVTRFQIYLQLKRDLLHGRLYCTANEAAMLGALIIQIELGDYDPSIHVGNYVTEMRLLLRQTDAIEARIQELHREPVEGSPCGTGGVKGLTTQEAERTFLKIACQLDTYGVDPHPVKDHRGNQLYLGINHGGILTFQGGRKTNHFKWSEVNKINFEGRMLPSSSDACVYSGGGLFSWGTKFKYVGRTEREILERDGLLAPRDHSEEGSSGGGRRKASSVPATPSTPMTGDFGYSSLPRSTHSAPLEESGGGGGSGGVVGSGEGEMCDGACLLSGAAVDIALACCDKTSAACPEYSARDLFEHSSTESAATHGTHGTHGTHASHAEEWRPALQPPPRPFSLLRAFVPSFLFVWLSLALTALLVFETDWPLLRHLKRKPEIISLRHHYYAPLKEYLKKKIVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE65</accession>
    <name>A0A0N0PE65_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="50" type="ORF">RR48_02472</name>
    </gene>
    <organism evidence="50 51">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="50 51" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="50">Ya'a_city_454_Pm</strain>
            <tissue evidence="50">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459934">
        <property type="protein sequence ID" value="KPJ19265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE65"/>
    <dbReference type="STRING" id="76193.A0A0N0PE65"/>
    <dbReference type="InParanoid" id="A0A0N0PE65"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000024">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="51" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="49">
        <location>
            <begin position="461"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="48">
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            <end position="384"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="EMBL" id="KPJ19265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="581" mass="64674" checksum="AE3D7D9B15D08709" modified="2015-12-09" version="1">MEVYLVSWELFRQLTQGSRTKAQACPWLGAMLRRNKRWQSIQYLPRKSNVRRQRAIPVSTPFPCADSLAWGRSRQRPHSVHRLRPGDIDVVAAIGDSLVAGSGALEEFALGAIVEYRGVSWCAGGDSTWREFLTLPNILKEYNPGLRGYATGTGEWLARNARLNVAFPVTSDEVAYKKAKILVARMRASPDIDMERDWKMVTVFIGANDLCSASCLSPVAWSPAAHARKLARALDYFYDHLPRTIVNLIPVLDVSVSVRVVRPLMCRLMHSLFCTCFHRGGGELADLVHMARLYQKAEVALVESGRYDGREDFTVVVQPFMRLFNAPPAPRQPLPRCTRIISGGYKSRRSAGGRTVRPGELPSEPAKPLLHSSSQGTHNPDKMLVDSRAGLSDDVTRHSLQTSPLYRPSLGIWRECISVHIGQAGVQIGNACWELYCLEHGIQPDGQMPTDKTLGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQCTGLQLKVFVTNRSCSVYDAKQRKVSSSEVTSESKYITAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEM6</accession>
    <name>A0A0N0PEM6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THO complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459910">
        <property type="protein sequence ID" value="KPJ19343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A0N0PEM6">
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    </dbReference>
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    <dbReference type="KEGG" id="pmac:106719339"/>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
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        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF2A"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="7">
        <location>
            <begin position="108"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="243" mass="27069" checksum="86BB9487324F9C7F" modified="2015-12-09" version="1">MKDPKQIQTPIEDLAELRSYFASHNVVREYIAHTSKVHSVGWSCDGRRLASGSFDKSVAIFNLEKSKLVQDFVFKGHTGSVDQLCWHASHADLLSTASGDKSVRIWDTRSHKCAASISTKGENINIAWSPNGSTIAVGNKEDLVSFIDTRTYKVVTEEQFNFEVNEISWNNDSDLFYLTNGLGCVHIMTYPGLQLQTVLKAHPGTCICIEHDPTGRYFATGSADALVSLWHVQELACLRVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEV6</accession>
    <name>A0A0N0PEV6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459670">
        <property type="protein sequence ID" value="KPJ20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEV6"/>
    <dbReference type="InParanoid" id="A0A0N0PEV6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6166" checksum="E8B0522F41929B52" modified="2015-12-09" version="1">MACDPASQRVIPVAQHHSLGPRAPVLIKTGAKRWVSINPGGTSGGGGDSEPALHGVVLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFQ4</accession>
    <name>A0A0N0PFQ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052180">
        <property type="protein sequence ID" value="KPJ21514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFQ4"/>
    <dbReference type="InParanoid" id="A0A0N0PFQ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11436" checksum="5BCDC1BD692F003D" modified="2015-12-09" version="1">MKSFTNLSQDLDDSSDDECPLFIVADEMQANNADADEVTDENPSANNSISNENNTNAKTKPEVDSDFYKCTCEDDFTENHMDILVPIVTLETVHDSPWTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I4P2</accession>
    <name>A0A0N1I4P2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461192">
        <property type="protein sequence ID" value="KPJ07037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I4P2"/>
    <dbReference type="FunCoup" id="A0A0N1I4P2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1I4P2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="3">
        <location>
            <begin position="759"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ07037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="862" mass="97241" checksum="0838A61F60264F87" modified="2015-12-09" version="1">MTDHSDNLWEKSVPSRESHVAEKKRETAKIDMDCYFGHPIDFPEGDLIKENSVTEMMIVFVYDTQCCVSEEDDPAEAVLYFHPGWVSDTQRHALAGQAIGSDRNIPDWVLKNRASLLTSIIKVYHGDMHTIAEQMEDPKRLAEKLYQIFETYLPVLQYGCHIFQRVPMLSLPKSASSVYMESMQVLEHCSKSVGVLGGVVLYNNKIIATQLPPSLTSYLTVVDPYRIKSPAESVQTETPLPLGAQLLVVYVARKTYDMLKKHADKMQDFYQNGEEMIAKFKKMQEAEREKQREFPQSGMKRDKSLLFTAVPEEDHTMISPPNKENTSENRKPSMPDVVPFTNKPRPRPNKLSLSFKTQKSLDEDAMENETKFTGQTSVCSTPMVEYKRLHGNMLSICQNPDNQTLEKSPDVEPDVLKNIENSAKLKIESEQRDNKMVLDINCIADHFINKPEPIRKLASVMDIQETFRKISNRATSKFKLKRSQNEDDSPAEETRSPSTLTINDPLFPVFRNDGVAISESLFNQYLEQYYSRMKQESKEENMFNFNIKLGEQEKFENFDSDMSKSPQRTPKKIVKDSNKTVPSDQSRRKALSLPLKSLTESTETATDSEAVNFKKKLTGVQLTPLMEKLSHLAFTSDKSSGYSSRVMTPLEIREFPTPAVERQLNFSDRSKGQREESEGEGEVEGESDDDLDALPEYGRAAAKCALFVSGLHNMALLALIDLEAADNVDTINNLWETSLNALGPIEQKCMEPLPAEAESSDYSYLMLDPDWGSVRKGGPWAAMDIATMGLIHNEFAEDPEISEYILRSEESVVVGASCGGGQLFYQESGARPPGPPPPSDAFAAAPLRARRRLHRDHCALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I4V2</accession>
    <name>A0A0N1I4V2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461184">
        <property type="protein sequence ID" value="KPJ07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I4V2"/>
    <dbReference type="FunCoup" id="A0A0N1I4V2">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I4V2"/>
    <dbReference type="InParanoid" id="A0A0N1I4V2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="391" mass="41948" checksum="E287381EE07AA2C6" modified="2015-12-09" version="1">MAADTAVAPTPEDTLESLLREAEALKQKLEEERQKLNDVTLSCVAERLEPVTFPNLKLRRVLKGHQSKVLCADWSPDKRHIVSSSQDGKIIVWDAFTATKEQTISMPSTWVMACAYAPSGNMVAAGGLDNKVTVFPLGPEEEGAGGGGAGGAALRKRTVATHTSYMSCCRFAHSDRQLLTAGGEGACALWDVESGQLLQSFQAHAADVTCLDLAASEMGDTFVSGGCDRAALVWDMRSGAAVQAFDAHDSDVTGVRFHPAGDSLATGSDDSCCRLFDLRADREVARYAKDNVIFGVNSVAWSVSGRLLFAGYSDYTACAWDALRAARVCVLCGHEHRVSCVQLAPDGTALATASWDSTLRVCSRVLVFPPLSLEANGKSHVFMLLHFQIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6W0</accession>
    <name>A0A0N1I6W0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNL-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6W0"/>
    <dbReference type="STRING" id="76193.A0A0N1I6W0"/>
    <dbReference type="KEGG" id="pmac:106717682"/>
    <dbReference type="InParanoid" id="A0A0N1I6W0"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ08663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="19538" checksum="42C499C3B3D93975" modified="2015-12-09" version="1">MTHRTVVNFLSKFHKPGLLNNILLRSGIGDSPLRRGHVYKQIPLITHLESIRTFATTPTALPDLSKLEQKKYEGKFQIMFTCKICNHRNSKFITKLAYYKGVVIIICDGCENKHLIADNLNWFTDMNGKKNIEDIMAEKGEIVQKIMSEDLEYILKATKEEQKEIPALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I782</accession>
    <name>A0A0N1I782_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_04412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I782"/>
    <dbReference type="STRING" id="76193.A0A0N1I782"/>
    <dbReference type="InParanoid" id="A0A0N1I782"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="377"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="452"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1050" mass="120793" checksum="7878F0791277E144" modified="2015-12-09" version="1">MLRSESLRQLLIISSLILCSISDGFIFGQMSGMVDDLRGKESQITLNDADVSLIASIINATCIMGFGVVALLSEKFGRRKTISILSIPVLVSYVMVYLGQDMATIVTSRVIVGVCYGGVLILTYIAMAEYMNPNKRAFYINLISATGPSVGTVLGHVLCLLLHWRTVALIGLIPTGLSAILPLFWVESPSWLASQGRFEECKKVYRELFGKSNASEAQLELLIETERAKRNEITGNKRNFAIVVEKMRTAMNKKYFWKIMVLGAVINIYRIAAGKLMFSTLAITMLQELTESSNILVSKYINILYLCVLIHNANLMDVSYYEILGVSKQAATQEIKQAYKKLAIKYHPDKNSDEAVQEKFLKITEAYETLKDPEKRRKYDIYGSHGAYTRKYDYQSQSEYNNLFYNGLYHNDPYVDEAVQEKFLKITEAYETLKDPEKRRKYDIYGSHGAYTRKYDYQSQSEYNNLFYNGLYHNDPYVVTLSSSTFYVHLTDGFHFINFYSPFCPPCQNLADHWKRFAEVYHGIVKVGAVNCKYHNSFCYHNMRIGSYPTLLFYPNGKIGNYIYYRGDDTFDALEEFVMNYIKSKIHVPVVSQLRSSEKPIAYVLEPNNIDDNALTRIAFHLKGLTTVVVIDDEELRDDLTEDPDTVVVFQYKKNHIEISSNDEKTIIKKIVESLPKMEEIDPNKLKDIRNKLRSGANKPWVLYFPSEDDDKLLLHQMKIKYPNMNFGTIDCKSQQELCVSLQVESAPCWAVLKWGGVYQRSYTPPDTFIQTAADVYNLHTLSASELQRILDGDVGTWVLLVVPYKLSWDHIAEPFTEVSKHYLDSEDINFGIMVCTLQTEQYCRRLAQNQPAILVQEGRNQHVYNGRIDIENIIDFIQLLKDSGSVSLSEQEALGIMTLSGRKHCWLVAFLPASCDRFCQDIAHQWRIIARRLRPLDWMRVGVLQCTESRGLCANVRQPTARLYLLNNKQHYTLNLQQKSEAPYILEWTLDHIDDSVEKLRWHTFAKQVAAEDIHPHMYKRPWLVYFHSPRCYHCFEKYPDFALAAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB73</accession>
    <name>A0A0N1IB73_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460144">
        <property type="protein sequence ID" value="KPJ17451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB73"/>
    <dbReference type="InParanoid" id="A0A0N1IB73"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="562" mass="64391" checksum="1EEC7726CA0BE5EB" modified="2015-12-09" version="1">MSQNKRLWVTSYWFSGCCCHSSESLTSDNANNASSQEKWVATRKNLVFEDSRRLDPVKLLNRKSRRTVQGEDYYYAPGNVTRITISGIQAYRSALTLDWLAAEDTRQRELVAAYETEPSAPARIITTECINYPRPSSGKVGKLMLELLKNLEGDDGVLVPELIHVLVRTKLLVETSMLDSEPDLESLVKTPMMMMGEPHITFPRILAIVWMLVTDTSTTRNNGWCPLLKVNKYLMSTKPTDIAKHLRVLEPVIARARFIMEEFIQNVTPLNMFQKQTEEITPLNDFDTTPKELPTNERGDILAKLPRSSGEEMEQSEDQDQPELPSLEPEYPSSPVLDQAQQIGYGQDEIEGETKSNAVAIYGLTPLLVLSSNVFGVWLVNTEVTEPATTDRRQNRLFKRQDDMADTCSRVKSTPRDIVRRVYAIMPYFDKDHANTAFLHKYRATIHGMSEGEDLLDREAALYASILTPLVFLQQYRDTWCLLERFHRAVRLYQISHPTEKRSSLKLLQNFRAVNQKIRSFIMELPGRRVVSRTSAPIDNEEEEIHDKKDIRYLKELIKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID11</accession>
    <name>A0A0N1ID11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052214">
        <property type="protein sequence ID" value="KPJ21526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID11"/>
    <dbReference type="InParanoid" id="A0A0N1ID11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="8468" checksum="7868DC20C5691384" modified="2015-12-09" version="1">MGIFTRAVRTAINSAHKHEPQVEYASDSDEAGAPGGGAPGAVGGGAPGAVGGGARTAHVDNLPHGITDTRLKTLAGDHVQVILVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IEG3</accession>
    <name>A0A0N1IEG3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDF receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01040832">
        <property type="protein sequence ID" value="KPJ21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IEG3"/>
    <dbReference type="STRING" id="76193.A0A0N1IEG3"/>
    <dbReference type="InParanoid" id="A0A0N1IEG3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13273" checksum="A946AD81C9E2B093" modified="2015-12-09" version="1">MRVLIVKLRQSQSSEMEKVRKAVRAALVLLPLLGITNILNMTETPPDSSVWNFGLWSYSTHFLRSFQGFFIALIYCFLNGEVRTVVKKHYDDYMSMRGGRRPARVSSSAERSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IF63</accession>
    <name>A0A0N1IF63_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin heavy chain, non-muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_01371</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461156">
        <property type="protein sequence ID" value="KPJ08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IF63">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IF63"/>
    <dbReference type="InParanoid" id="A0A0N1IF63"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007298">
        <property type="term" value="P:border follicle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000003">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000007">
        <property type="entry name" value="Myosin heavy chain, non-muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="85"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1577"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1826"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1875" mass="213479" checksum="EED4CB2C36CE38F0" modified="2015-12-09" version="1">MVDMDRNDPELRYLSVDRNSFNDPATQAEWTQKRLVWVPHDTQGFVAAGIKGERGDEVEVEIAESGKRMLVPIDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYVLQIAGLHNPALYMAGAGLDLRKVGRPYGLPYREDQSILCTGESGAGKTENTKKVIQYLAYVAASKPKGSGAGPSPQLIIGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGYIAGANIETYLLEKSRAIRQAKDERTFHIFYQLLVGATPQQKAEYILEDPKNYPFLTNGSLPVPGIDDAAEFQATIKSMNIMGMNMEDFNSIFRIVSAVLLFGSMQFKQERNSDQATLPDNTVAQKIAHLLGLSVTEMTKAFLKPRIKVGRDFVTKAQTKEQVEFSVEAIGKACYERLFRWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPMGIMALLDEECWFPKATDKSFVEKLVLAHSVHPKFMKTDFRGIADFAIIHYAGKVDYSASQWLMKNMDPLNENVVSLLQSSQDPFVCHIWKDAEIVGMAQQAMTDTQFGARTRKGMFRTVSQLYKEQLTKLMATLRNTNPNFVRCIIPNHEKKAGKIEAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNIIPKGFMDGKKACERMIEALELDHNLYRVGQSKIFFRAGVLAHLEEERDYKITDLIVNFQAFCRGYLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYIKAELELCAEAEESRARAAARKQELEELLHDLEGRIEEEEERCNALQQEKKRLQLNIQDLEEQLEEEEAARQKLQLERVQCDAKLKKLEEDLALSDDTNQKLLKEKKILEERATDLSQALAEEEEKAKHLSKLKTKQESAIAELEEKLLKDHQLRQEVDRAKRKLETELQDVREQLAERKAQLEELQIVLSKREEDLAAAQSRLDEEGALRAAAQKAAREAESALADAHEDLEAERNARTKAEKLRRDLNEELEALKSELLDSLDTTAAQQELRSKREQEVAVLKRSLEEEAAAHEASLTEQRHKHSQELQLLNEQHEQLKKTKAVLEKAKQALEAENADLATELKSAAAARAEGERRRKQAEAQLADLAAKLQDVDRSRAEVQEKCQRLQGEAEQALQQLEQAELKASAALKQAATVGAQHAEAQALLEEETKQKLSLQTRLRNVEQQLEQARDQLDEEEEAKKNLEKQVAALTQQVVEAKKKAEEEAETAAALDEQRKKLSKDMEALHRQIDELQQANDKLDKSKKKVQAELEDTNIELEAQRAKVLELEKKQKSFDKVVAEERAVAERNAAERDAAERDARDKETRVLSLTRELDDAAEKIEELERSKRVLQAELDELANTQGTADKNVHELERAKRALESQLAELRAQNEEIEDDLQLTEDAKLRLEVNMQAMRAQFERELQAKEEQGEEKRRGIVKQLRDLEAELEEERKQRAAATAHRKKLEADLKDAEQALHLANKVKEDATKQVKKLQQQLKEAAREAEEARAGREEAAGAAREAERRGKALEAAAAQHAEELAAAERARRHAEAERDDLLDELAAAAAKNQIDQLTMELGTEKAATQKMESGKLVLERQNKELKAKLAELETAGRTKTKGVITSLELKVSNLEEQLEAESRERLAQQKASRKLDKKMKEMLLQLDEERRHADQYKEQIEKMNTRVKTLKRQLDEAEEEVQREKVGKRKAQRELEDMLETHETLSRECSNLRNKLRVYCVGRRSQTLALVTSGAATNDRRQGGGIGLSGASSSSRLKRTSLAPGAGSGDESFDDVNDTTNSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFC3</accession>
    <name>A0A0N1IFC3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFC3"/>
    <dbReference type="InParanoid" id="A0A0N1IFC3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7773" checksum="B129F0CC9BC68E43" modified="2015-12-09" version="1">MSIAVDEHLGVPAARTRRRGRPKQIWRRSVAADMKTVGLTWLETKRRTQDRVRWRRTVDALCPTTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFY8</accession>
    <name>A0A0N1IFY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460622">
        <property type="protein sequence ID" value="KPJ13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFY8"/>
    <dbReference type="FunCoup" id="A0A0N1IFY8">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106712510"/>
    <dbReference type="InParanoid" id="A0A0N1IFY8"/>
    <dbReference type="OrthoDB" id="6415470at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="42850" checksum="A4BD6995A3CCFE9B" modified="2015-12-09" version="1">MFGLKLKYFLNSSNIIVRNLRNRRRPELTANPGLNKRVKAFQEQGIKIEDEDAEEFLEKSNSSFYNVGEAYNEHLNETLIGKYDLQHKIVKEKYFKENMPNLLTWSEKEQIRHLATTQPDEWTPQRIAESFPVTVPVVKKLLKYPWKPATEQRIARHDASAMRNWRELKEGNLNIPEDLRKHFLKFSERQIPPLNQKSIKVDLTQAEKIGEFEQIIQRCAQKDNTEKETKMSEKTQQNNNNERSNKKVIKDPQRMTLEDLTARIKERLESGSEVDTPDRIIIDTVHTEKSKLLNNKEIDLISYKQETDLKEYKESDKSITAIDYPERIRIPKKAYKKGATYKIKDCYYDHDGRFLYRVLGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IG90</accession>
    <name>A0A0N1IG90_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA-decapping enzyme 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_04260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460882">
        <property type="protein sequence ID" value="KPJ11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IG90"/>
    <dbReference type="STRING" id="76193.A0A0N1IG90"/>
    <dbReference type="InParanoid" id="A0A0N1IG90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="56"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="349" mass="40744" checksum="D201EE0321030169" modified="2015-12-09" version="1">MDEIRQYYSRKGGGTDHTTIKVNIYKFYTVYLHVPQLREHVSSLDAVLDNWREYKQTVPTYGAILLDTDLTHVLLVQSYWTKASWGFPKGKVNEDEEPWKCAAREVLEETGFDISKLINKNDYIEAIIHDQIVRLYIIGYIPRDTKFQPRTRNEIKACEWFPLADLPSNRKDMTPKVKIGVGPNAFFMVVPFVKRMRRWVAERSTRVYNSTRRMRHKSMGELESVTNKNKQKISSGLQNEIQEYQNEHKFKNNGHSNINQGNSAQRNHVQENHAGNASGSKHNTSNNYRKEKKQAKRQLFTPQNTQTNNFSPVQKDNSYENDDNSLLNFMAPSWANFKFDRRAILDCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHT4</accession>
    <name>A0A0N1IHT4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_04496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHT4"/>
    <dbReference type="InParanoid" id="A0A0N1IHT4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001495">
        <property type="entry name" value="Datilografo, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000433">
        <property type="entry name" value="zinc finger protein 384 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="584" mass="63072" checksum="3162061C693632AA" modified="2015-12-09" version="1">MQMHARELQRGLGGEVKPHQCQQCLKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTHTAKELQLHLGVLQQHAALMIGGATATPCPICHKVVFGGEALVEHMKNTHKDPNASGVASPPATSPYPAQAKPIDPYIAKRRTANHPCPVCGKHYVNEGSLRKHLACHPETQLTSSLRMWPCSVCQAVFTHENGLLSHMEHMRMEPKHQFAAQYVLSRAAAERRERDILAAVSASAGGSGLLNLAPPSPTHSDSSSNGRLSSSAGSEAGATVNKLSDLLRSNNGQAYGDERVAAIAAAAANMMAQPGEGANAVQVAAANLVSAMRQQLAREPPPETPAPNEATLRMQQAEALLRSQAEALRLAVSQAAAAHNTEPPSPLRHNGGFPTPTNDASGQLSPELVEAFRIAQEQRLEQALRLHDPRMLGFNIPSPQQVAQQAAQQAAQQAAQQAVAAQHAAQAQAQAQAQAQAQAQAQAQAQAQAQAAQHMQQSSLQMAQAQAAQQAAQQAVHLQQNPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1II42</accession>
    <name>A0A0N1II42_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase member H-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1II42"/>
    <dbReference type="InParanoid" id="A0A0N1II42"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="353" mass="39843" checksum="46D993249CA049A8" modified="2015-12-09" version="1">MAKCTLSMPAVKRRGPGSSKQAIITKKALKYLSFYVQGPGNIFNARHVKYTYFQMHQLARDKDIDFKKKTLLYVGGFLDSPNFPIASSLAAVYHELNYNVLLLDTNTFTTMEYPMAVRFMRPVGKHVAKMLAVLVEEGLDPKKLEVVGLSLGAQTMSYVAKAFQEITGKNISRLTGLDPSGPCFRNLGPEERLDMSDADFVDVVKTNIDGFGLAAPTGHVNFYVNGGEYQPGDVLWMPCNVMCSHVRSFTLWIAALKYPDRFIAIQCDSVQQARNRECYDRRPLVTNILGLNVDKTKEGIFYLATDNNYPYYLVVDPANTIFVGYTYGPDRPVQYHDHTEDRREVEAILRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJ33</accession>
    <name>A0A0N1IJ33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460037">
        <property type="protein sequence ID" value="KPJ18392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJ33"/>
    <dbReference type="InParanoid" id="A0A0N1IJ33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="6711" checksum="18F1693E557D670D" modified="2015-12-09" version="1">MSIGPSAGPAGFGGNSARCRVVQSGVTHLPGRLERPEFECRPPCSRPAAETKSQSMLVVRGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IKW2</accession>
    <name>A0A0N1IKW2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01031591">
        <property type="protein sequence ID" value="KPJ21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IKW2"/>
    <dbReference type="InParanoid" id="A0A0N1IKW2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="75" mass="8450" checksum="602CD49DFD31266C" modified="2015-12-09" version="1">MKLPRFCSASVMFAQAQTDGFHAIIRKKVASLVRRLRESDNSILKAIASDPKAPVLRHLVRTMIPQGMSPKYMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-05-29" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INU5</accession>
    <name>A0A0N1INU5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acyl-CoA reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INU5"/>
    <dbReference type="InParanoid" id="A0A0N1INU5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF107">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="1">
        <location>
            <begin position="116"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="223" mass="26079" checksum="2C77B1FD2554FB3E" modified="2015-12-09" version="1">MMLSIFNACTFNTCNDRSRNNNICWVHEWAGLTECNTTTRQKTDVKWKQFRISSDEPGRCPVYNVTSGSINPLQWGQFTRLCIKWARENPTKYVMWYPNFSFTESRFMNTFWEISCHFLPAFLYDVLLRAQGRKAIMMKLARRFKMAAATGEYFANHEWQFGISELTALHAEANCASDSSAFPHWPAQFNWDTYIGAYMLGIRRFILKDSVESLPNARSKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPP8</accession>
    <name>A0A0N1IPP8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome c oxidase subunit 4 isoform 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RR48_03648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Ya'a_city_454_Pm</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460141">
        <property type="protein sequence ID" value="KPJ17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPP8"/>
    <dbReference type="STRING" id="76193.A0A0N1IPP8"/>
    <dbReference type="InParanoid" id="A0A0N1IPP8"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="13" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="17">
        <location>
            <begin position="363"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KPJ17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="555" mass="63168" checksum="9413651CB4BAA437" modified="2015-12-09" version="1">MSYVLLKLYKPNIYCITRSIHNRCRIGCRDVVGHGINGSAAYRDDPHFPFPSVRFKENTKDICALREKEKGDWRQLCCEEKKSLYRASFCQTFAEFQAPTGTWKFVAGWVFIVTSFAWWLAMFYHHYVYEPLPASFSKLAQKAQLRRMLELRVNPIDGISSKWDYDNDKWKLQVLQVDTNMKCAVAIVLALFGLSVANPVGHVLTSPAASGYSSVINHGITVPVIQIPRVYIVPKVIQAPIITSVYPNLDHSWHVEEEPVRRNMYRKSEKYNSLSIDISPSEPSMHITKVTTETTEPTVVMATHRKKLKQNKNYVNGKPINQSLNVNQYLPKEIEITTEIKTPSKHEIITEPTTLSNRQMRRIYNPDETASIEDYPFMAVLLMNGKLWCGGAIIQEDTVMTAAHCMQLQYNNRFFREYVKMLTVRVGSNNATAGGHVYRVTDIFFHPNYKPNTLEFNVAVVKLHKNITIKSERNVDVIGYSSEKHIPTDTEITFLGWGSVWHDAGGPAIMDGVLVGILSFSAKRCDKPDKPAVFTSVGAVADWLTNVDARKKSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPR6</accession>
    <name>A0A0N1IPR6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">RR48_01080</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Ya'a_city_454_Pm</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="KQ460120">
        <property type="protein sequence ID" value="KPJ17679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPR6"/>
    <dbReference type="FunCoup" id="A0A0N1IPR6">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPR6"/>
    <dbReference type="KEGG" id="pmac:106707962"/>
    <dbReference type="InParanoid" id="A0A0N1IPR6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01167">
        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KPJ17679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="152" mass="16506" checksum="A1B6B22CA6974708" modified="2015-12-09" version="1">MKAVRHMRKDEGGEGGTIVNISSTAGLCKYTFLPIYGGSKGAVLHFSQSLAREPFYDNTGIRVITLCPGPTATKLMEGLDNRIVETSSMKQIQSLSDVQIIQSIPSAVAAMMKLLKEGDNGSVWLSANDKPVVELTEKINKHLDELEKLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQM0</accession>
    <name>A0A0N1IQM0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035259">
        <property type="protein sequence ID" value="KPJ21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQM0"/>
    <dbReference type="InParanoid" id="A0A0N1IQM0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="74" mass="7988" checksum="D56F5B42C242B56A" modified="2015-12-09" version="1">MKENIVMLHISEKYKSKKRSSPGKRKAARGAYTARGATSAAGSRLGNMPVPRSNTAVSLNTRPGVFKTSKLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQM7</accession>
    <name>A0A0N1IQM7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurexin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01006280">
        <property type="protein sequence ID" value="KPJ20900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQM7"/>
    <dbReference type="STRING" id="76193.A0A0N1IQM7"/>
    <dbReference type="InParanoid" id="A0A0N1IQM7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="67" mass="7549" checksum="9A175F18250B7280" modified="2015-12-09" version="1" fragment="single">LYIGGVPNFQEGLVVDQNFTGCIENLYLNATNVIQEVKQGYDNGEAFKFQKVNTLYTCPIIEAFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFC5</accession>
    <name>A0A0N1PFC5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centromere/kinetochore protein zw10-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFC5"/>
    <dbReference type="FunCoup" id="A0A0N1PFC5">
        <property type="interactions" value="1534"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFC5"/>
    <dbReference type="InParanoid" id="A0A0N1PFC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="2">
        <location>
            <begin position="268"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="3">
        <location>
            <begin position="524"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="4">
        <location>
            <begin position="712"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="98455" checksum="704996813972C5F0" modified="2015-12-09" version="1">MTDKEDATKQPENQPLDDEALEKLAVEELLREAVQGAARAEIVGPSGWVKSAPQKSNKRFLVNTLRHTVSSNKYYSSRSSHRSSYRSYNYDINSILRTRIIDVDESKWKPSDKIPLINKEIEQVKAEMKTFLQSSDFDVASILREGKELIIESKSLMLEMEGCKNQIEEETLKEIKNSMENHDIIGKELECVNFSLNILNDVLQIGNFVKEFDVGREFQSFVKAVEAVSDLLKYIEEPAEGVQDLLLFESTKNTAHLILDNLIHDMFEEWDRMIVYSSEPGPESTIIKLNLTLDKTLSTLDVLKGLDRCGKLLDKVTQLAQFILSEILIPIIHYDCTVFAEPDQLMTVTITYRDNYKPPYYDVITNLRLLFHYLSNRLNFVINSVGEPIITMVGRLISEEFRDILVKDCLIDTIPNNINDLQIYGKITGEIEDFQRFLYMVKFSHDEDFTILNYINNIDVLFAAKSSQHFLEKARSIMIKDLSASMSIGVENIPVNSKDDENSEDEMIEQGLDVLHQTIPKSLFYFPRCMISKSAQELLDLVYVVMEQAVQCSDVVSKKLYNTARLIFELYDAVVPYHHENFLQNIPQNVALFHNNCMYLAHNLQTFGDKWLTLMEGREVDYAIGFVDLVPKLRELGCRHLAVHMQQQRKQILDNIRTSGFVDLVPKLRELGCRHLAVHMQQQRKQILDNIRTSDLNCIVVKDVLDDNAEAAIRQCLRQLHLLKNVWIGVFPSNVFIRLMATLINMFIDELIHRVCTVEDISMEMAAQLNEMYTLVVQKVPQLFPDGTDVNVYVKSWIKLQELVFVLGGSLRDIDLHWDDGAGPLAKHFTTDELRSLIKALFQNTQFRANLLSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PH05</accession>
    <name>A0A0N1PH05_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_02506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PH05"/>
    <dbReference type="FunCoup" id="A0A0N1PH05">
        <property type="interactions" value="1390"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PH05"/>
    <dbReference type="InParanoid" id="A0A0N1PH05"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="75"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="440"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="588"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="815" mass="93881" checksum="663F5190E8A592DD" modified="2015-12-09" version="1">MGLIRKSLYYGLNLRIYTSNNFCINCIRAKSSAEVKTKTYSHTILFPKTLFPTRSNNAIKEEVQKMAQFAELYTWQRENLKGPEFVLHDGPPYANGDLHMGHAVNKIIKDINNRSQILQGNKVHYVPGWDCHGLPIELKALQKAKKSSKNISSPVHIRQIARDFALETVAKQKMAFQSWGIMANWDTCYLTLNKNYVQNQLRQFYKMYKSGLIFRALKPVYWSPSSKTALAEAELEYDPQFKSKEVYVKFPLESVPVAANNVISGLLTSEKLPFLEASHVTEGKGTGLVHTAPAHGPDDFLVALKNNMTVECNVDESGRYINLGDRFDGLYVLGDGQDEVINVLEDSIIHKNVYIHSYPLDWRTKKPVIIRASQQWFIDTAALKDKALVKFTFSLITLKKIFFFFFFWFITFFIFTCLDVCHEILRIKFDPLLIEKLCNLIEKNNTDVWWTCDVRDLIPDDVRNKYNLKYEEVSKGNDIMDIWLDSGLSWQTLEGKRANLYSEGVDQLTGWFQTSLLTSLALTGEAPFKWWAASHSTQHSQIVISKKLLEDCQSEVIRIRAIIKYLLGVVSDMDKGNFVVQPKLNYFDQFIIMETYNFLQQIIDHYNNFRYNHAAQSILFFISNKVSSLYCHCIKDRLYCSAKDSDQRQSAQLTIHTILVALCKAIGPILPHLIEEAWQHHPLYVKPFYFTKEIPMLPNKNIDTSLMVAILEIKRDVCVLNKNENLKKFNLHLKLNSDLFCKLNTLNYSDDIDDSVLTEILEVSSVSLEEVRNGGKPWHIELSKSKKNQCLRCRKYNVLDNSDKCLRCESVVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHJ8</accession>
    <name>A0A0N1PHJ8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460041">
        <property type="protein sequence ID" value="KPJ18361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHJ8"/>
    <dbReference type="STRING" id="76193.A0A0N1PHJ8"/>
    <dbReference type="InParanoid" id="A0A0N1PHJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="4">
        <location>
            <begin position="123"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="5">
        <location>
            <begin position="406"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="3">
        <location>
            <begin position="605"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="980" mass="109534" checksum="9FB7698E63F0ACC7" modified="2015-12-09" version="1">MTDEDSPIVHYYPVHFETDLNGKRNDWEAVVLIPFIDEANLLSAMAPCYQRLTEEELKRNSHGPMLIYNWSPANLGVAFAPAYFPPITENHAIELLVWRSKLDVPEDQLKRGMLPNAKRDLLYPGFPTMRHLKYQTSLVKKHVKVFDQPSRNENMIVEIIREEEPPVEQVARELLGKVIWVGWPHLTKAKVISVSNEKMRLHYIGKNNVDVQGTYSTEMNAGNLHKQWISERSTIIEHNMNRLGIELGDVNIIVHAVNIKGYKYIIQDNTKMVRKAEWCEVPCGYALQAVVPSANAYVTQTPGKFCSPQEAYPAGDHVFLLTHGQYYGSLAKIVESEGMGSGRIKVLVREASEPVPSCSATASPYRTAHHAAAACAIQIVESEGMGSGRIKVLVREASEPVPSCSATASPYRTAHHAAAACGISAQMLSRITGTVLVILGERNNLPTENQNKLNIGLNLKFNKKNQEVSGYTRRCTVSNAWLYSERCINLVKSYAQQFPEIFDNLPYHYDKNVIFEEELWPGEVGEKKPQAVMSWLKEQGHGKAARRACGSQALEPEELRALAEDLDVQLQRAQIEKTPTLHVKWNLLYKPELHEGNLSTDPKADYEMFDRVVCVSRTMSVPFGLHGTITAVYQPGDCNTVRLADKLNATPSYQVLFDKPFPGGMVEEGFNEPRFYRMQDTKMLNISYGRKLRTAHAPAEPEWAALNTPVLLRRDQHRSAFASYSPPGDRQTPIADNKNKAVPNIVNNGGPPDNATNLLRSLLKISENESDLNKKNKVTATQDNWRNESNPSFSGSRPPTQSLPNEWTNSNFKNPPPLPQLMGVPKPFQGPGAAHLPFPQFRPHPPQSHPPHHTHPPHPMLANKTPNNIVLGPSWIQGNNVSTVSGGGKSAGIQNTDRVANPFVPLQVQTSQRRVQNNSVPSSRREPEGAPAQSLQQYSTQPQHTLQQDGPTPQQSQNAKKKPQRKKKPRIAANLPFQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHT2</accession>
    <name>A0A0N1PHT2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460648">
        <property type="protein sequence ID" value="KPJ13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHT2"/>
    <dbReference type="InParanoid" id="A0A0N1PHT2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="464" mass="52773" checksum="529B25EDB2DF0AED" modified="2015-12-09" version="1">MSQDDTMTSAQECAENSVYHDTGDSNAQDGHERDHEENIEETLNNLENSQDKDFPDELGAFLIRKSDGKPIKKEIDGRDSEMDSTKHTDDDGHDTDEFPLPSHECHIDKDFPDELGAFLIRKSDGKPIKKEIDGRDSEMDSTKHTDDDGHDTDELLRMLGEDEAKRKKKPSIKLVKKERKDDSSDEDDDFIFGSTKVTRVRVAKDYIKKYATKAEPEDLSDKEEMSDEVATMKNMFVTRRPGHAALGPRPRHVAAKSTTLGGINALQTVTKRVVSLDGNTNKRPMPPTSHRQVILKQVSKEEPKRERQSMKESEEIINEEEFLDEDEFDLDEVGELETDDEDGSNRQKMRQRIMRPERMDEEVPSDGDSNSDESLYDEIQSSESEDLDEWFTLDIRAERAGDYLPLLGTKAKQLLIKERNRVGARLATLDQSLLALRDSGRQQAQQLRRATAALHDIDNALRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIC5</accession>
    <name>A0A0N1PIC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIC5"/>
    <dbReference type="InParanoid" id="A0A0N1PIC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="88" mass="9893" checksum="986B4B8B2F16E63A" modified="2015-12-09" version="1">MQCSKIPGNKNQCCQMKCDKNGCVCIQTEGQSNVWLCLDDKKNIIKCQEKKSECKYISTEGKSCICVCVGDNEEIKVCDDCKCIPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIM7</accession>
    <name>A0A0N1PIM7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_02798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIM7"/>
    <dbReference type="FunCoup" id="A0A0N1PIM7">
        <property type="interactions" value="1709"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PIM7"/>
    <dbReference type="KEGG" id="pmac:106709125"/>
    <dbReference type="InParanoid" id="A0A0N1PIM7"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="635"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="880" mass="101466" checksum="0A00ED7D7CFC44CE" modified="2015-12-09" version="1">MSRFFATGTDSESESSSEEEQVVRAPAPVYTFSDDEEETKRVVRSMKEKRYEELEGIIHSIRNHRKIKDFSSALASFEELQRAYTRAAPVVQKEENGIAPRFFIRALVELDDLVAGAWADRDARKALSKGNSKALTSLRQKLRKYEKDFDAEITKFRENPDLPDDDEERKDTSSSDESDDEDKVKEKVRVRRSPEPPRRPPPQDDESSDSMDWGSSSSDSSSSSDDEARGAATLRERFLKKTTERDDDEEGDKRRARRERRERGAGKISKRDQTDDGGEWETVRKGAATSDKPKMFAKDSDIDAALVVKKLGEISAARGRKRTDRRAQLELLHELRTVAQQHNLGDALQLKLRAATVAALFDYNPKVSDAMKPEYWSRLVENVDHMVTLLLAHEDMQLSETITEENEEFVTAPFRVRGCVLTALERLDDEFTKLLKECDPHSNEYVERLKDEVRVSALIDRVCQVVERDGSPQEVCRAYLRKIDHLYYKFDPRAVKKESPPGEESTVKKMERLCKYIYAHDESDRLRTRAILSHIYHHALHDNWFQARDLLLMSHLQETVQHSDPSTQILYNRTMANLGLCAFRRGNVKEAHGCLAELMMTGKPKELLAQGLLPQRQHERSKEQEKIEKQRQMPFHMHINLELLECVYLVSAMLIEIPYMAAHEFDARRRMISKTFYQNLRASERQALVGPPESMREHAVAAARAMRRGDWRACLNFIVNEKMNAKVWDLMVGADNVRAMLGRLIREESLRTYLFTYAHVYASLSLRSLADMFELPRQRVHSLVSKMIINEELLASLDDPSECAILHRSEPTRMQALALQLADKVGNLVDSNERIFEKQGSFFQRGGAGRGEGRQRERPRDGWGRRQRNRRRDDERGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIZ7</accession>
    <name>A0A0N1PIZ7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synaptic vesicle glycoprotein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIZ7"/>
    <dbReference type="InParanoid" id="A0A0N1PIZ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43938" checksum="84C128DEBA82FAE6" modified="2015-12-09" version="1">MTVATAKLSLKAMNAPIEKILEHNTQIALRYRDAPIKEGLVKIVCADTNVTLKLLHSALFSVTAYIARASALETMVCETKETEDQLPFDEALEKTGNGIYNILLAATCALSLLAIGADLFGFSLVVTAACDLHLTVAQKGILTSTPFIGECWCRMIVSAPQKCCFLFCCVHLRKCMADHRMWSTFIIRMPKDDYMIVYLSCAANSVSYTLVGESCVRRVRNKYMVMMTCFILFSPAFAALLTYPILKLDFEAPIQCLGIVFRPWRLLNIILALPSGLGALALYFFHESPKFLANCGRREEALEVMRSIYAVNHSCSKEEFGITSFTMSESAKKEQSLFRAMYEQSAPLFRPPYLWRTLQLYFIVAVVFITVVAAWFLPPDKPLESAEKPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ70</accession>
    <name>A0A0N1PJ70_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01035082">
        <property type="protein sequence ID" value="KPJ21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ70"/>
    <dbReference type="InParanoid" id="A0A0N1PJ70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23079" checksum="3A271C70DF6182A1" modified="2015-12-09" version="1">MFNAAVRQAQDIHCSYCRDTGHGVTGCPKFRELRWQARRGIARQRFWCYCCLGDHLVSHCQSTRACGQCGGRHHLLLCGNRNGSHSPNTRGLVTSPVRSKNAGEQWSGAMQRTSGRRDVRSPPRLRANSGRQCVQGSPTSTGGGARDSCSAPQAAAEEPCTGGARSPLHFMDWPRLERRRPHQSDHQVVSDQDRISSPRLINNHSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ91</accession>
    <name>A0A0N1PJ91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain-containing protein KCTD9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ91"/>
    <dbReference type="FunCoup" id="A0A0N1PJ91">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJ91"/>
    <dbReference type="KEGG" id="pmac:106720493"/>
    <dbReference type="InParanoid" id="A0A0N1PJ91"/>
    <dbReference type="OrthoDB" id="9989223at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18368">
        <property type="entry name" value="BTB_POZ_KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000002">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="403" mass="44431" checksum="9286B23D62FC9135" modified="2015-12-09" version="1">MRRVYVYKNKSEDDGKLMAVEDSIETFKSQISLHFNMGKENLKLYSSNGCEIVDLRVIRDEEKLYLSLDTNSSESCETVTNLGYFSQSSIDSERIVSDWITLNVGGRHFTTSRGTLLAKEPLSMLARMFADDNNVYLMNPSATDSTGAFLIDRSPDYFEPILNYLRHGDVILDKHINPKGVLEEAVFYGIDSMIPHLNQLIEESTSNSSSNHCLTRKDVVRSIILTPTTSELRYQGVNLSGADLSRLDLRYINFKYACLSGCNLSGANLSHCCLERADLSHANLEGTQLLGVKALCAHMEGAILRGCNMEDPAGSRAVLEGVNLKGANLEGSNMAGVNLRVATLKNANLQNCDLRTAVLAGADLECCDLSVSDLHEANLRGANLKDAAFELMLTPLHMSQTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJD2</accession>
    <name>A0A0N1PJD2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_01515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459894">
        <property type="protein sequence ID" value="KPJ19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJD2"/>
    <dbReference type="KEGG" id="pmac:106717244"/>
    <dbReference type="InParanoid" id="A0A0N1PJD2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="20743" checksum="0241BC1CAA60C864" modified="2015-12-09" version="1">MTTQEVDDEHPQSIIKNEDEEISEKPVQKMKPPLDTKVPKSSKVLTKKNKSNNPLTCNICQKTFNSSQPLRFHIRQMYFNLKAKTLLHEMKKVKQVWVEKVLNSNDLIEITKTGPNTLLMKKTERNAIVEPNVEIKEIDLSYLYPTYNKYHYKECTICEVKVPRKRYKKHIVSHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJZ6</accession>
    <name>A0A0N1PJZ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase isoenzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_00529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01044237">
        <property type="protein sequence ID" value="KPJ21415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJZ6"/>
    <dbReference type="STRING" id="76193.A0A0N1PJZ6"/>
    <dbReference type="KEGG" id="pmac:106707397"/>
    <dbReference type="InParanoid" id="A0A0N1PJZ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ21415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="12805" checksum="66B743723130FB99" modified="2015-12-09" version="1">MARAADSKGFLIDGYPREKSQGIAFENTIAPVTVILYFEASCETLTKRLLGRAASSGRADDNEETIKLRLKTFLDNNDLVLAQYPDKLRRINAEATVDQIFSEVQKILDPIVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PK97</accession>
    <name>A0A0N1PK97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuroserpin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459937">
        <property type="protein sequence ID" value="KPJ19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PK97"/>
    <dbReference type="STRING" id="76193.A0A0N1PK97"/>
    <dbReference type="InParanoid" id="A0A0N1PK97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="165" mass="18393" checksum="486E46770396C04C" modified="2015-12-09" version="1">MFNTKVQVTIPKFKIETEIDLCDLLPKLGIKAIFDSNNSGLTKVLNTDEKLYVSKAVQKAFIEVNEEGAEAAAATAIKVRNKRSLSSPRVFRASHRALWCVLVADRITFMAAYRPRVPTLPMGIMLCSAVIGEPPVPRFDADRPFLTVILVDDTPYFMATQRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QML1</accession>
    <name>A0A194QML1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QML1"/>
    <dbReference type="KEGG" id="pmac:106719807"/>
    <dbReference type="InParanoid" id="A0A194QML1"/>
    <dbReference type="OrthoDB" id="6363452at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012204435" evidence="2">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="242" mass="26554" checksum="BF4E3DCEE3A6E39F" modified="2016-10-05" version="1">MVVLYSLLFCTFAVAAEHSGAYSSPQYAKKMFPKKSFDTSLLLPQEKPPIPFNRASIDRFDSVNDTTQYGRSSFLDSAGNLLSNAGGQVVSSLAKDFIARSTGSSQVLSLNLTNLVILIILKALILAAGFFGAGAWKGHHYGRSIDENKNATYLTEDEVLLYLSYLRGEQSKDYGCLYRLACQKPRQGALYTSAAELMLQGAKLLQGHSDNLVDYENIYSGIKQASTWGDNGKPCDKIYKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMV2</accession>
    <name>A0A194QMV2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Embryonic polarity protein dorsal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMV2"/>
    <dbReference type="STRING" id="76193.A0A194QMV2"/>
    <dbReference type="KEGG" id="pmac:106719450"/>
    <dbReference type="InParanoid" id="A0A194QMV2"/>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF25">
        <property type="entry name" value="DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="497" mass="55219" checksum="EAA3E75BA2A3A39F" modified="2016-10-05" version="1">MANHLPIQRRAIAQKTPEPKGSSKKPSVRVVVQPVDSHRFRYKSEGRWAGSIPGVNKKGNREGFPTIEISGCPEGKAVIVVSCVTKDSPYKTHPHGVVARELFMSEEEVKKGACKVVVELTGESTKVSFTNIGIHSCKHNEVKEVLETRRRLGVDPFGSGFDYGREPKRIDLNALRLCFQVFVMDEKDGIRLRLPPVVTSVIHDKKTQGELHITRLSHCTGPATGGTTVILLCKKVKPSDTTVVFVERGAGGGAVWEAAASDVSAHQHVAFCFTTPPYRHTDITQNVTVFVQLKRLSDNARSEPVEFVYTPARRENSPMESDMSHEQVSYNSAQSPLKQEPLPTEPKLLQPWPTDLPPMLGPSPQHQYQVQDVSWMDKSYVQLDQLPPSPSLQATSPHAPHLTTNYSLTSRGFGFSQARNLNPFTSHYDEYVYVPDNRSECNSVSPIFAKSPDLNTEQAEEMQISLEKFSGILEEQISDHLSELSLKEFVGGDLPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QN85</accession>
    <name>A0A194QN85_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_11471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QN85"/>
    <dbReference type="FunCoup" id="A0A194QN85">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QN85"/>
    <dbReference type="KEGG" id="pmac:106719471"/>
    <dbReference type="InParanoid" id="A0A194QN85"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="284" mass="32480" checksum="186D942B05CC5CF6" modified="2016-10-05" version="1">MTSLLINAFKRLNLSIRPQVKVISSCYSTAVTTSNSLNVTQKEWKYPPVYTKPREVWIENLDTVEEKKLGLFELHPSVYAAIPRIDIIHRNFVWQTKYRWVSWAHTKTRAEVRGGGRKPWPQKGLGRARHGSIRSPLWRGGGVVHGPRSGKTHFFMLPFHLRIQGLTSMLSAKLAQDDLHVVNNLELPTDEPNYLADLIENRNWGPSVLIIDDTDIAPRNITVATDSLPHVNVMPVYGLNVYSMLKHDTLILTLAAAERIEERILHHLNSITMEQQREFKLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNK8</accession>
    <name>A0A194QNK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SOX domain-containing protein dichaete</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNK8"/>
    <dbReference type="InParanoid" id="A0A194QNK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="207" mass="24685" checksum="4C8AB3648EAFE770" modified="2016-10-05" version="1">MSRNSNPYHIKRPMNAFMVWSRLQRKKISMMNPKLHNSEISKRLGLEWKSLDETEKRPFIDEAKRLRLKHMHDYPDYKYRPRRKNRLDTTYTNPAIYSRDAFVEIEPRADQNYQIPVNYTEHQFMYNNMMSYPVPTISQTSFVPTTIRPKEEALPSLDLRPLPSIESISPRPFAVVNQQMMVKAYQDLHYVPGDVTRISYHYPFGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNL5</accession>
    <name>A0A194QNL5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor Sox-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNL5"/>
    <dbReference type="FunCoup" id="A0A194QNL5">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QNL5"/>
    <dbReference type="KEGG" id="pmac:106719263"/>
    <dbReference type="InParanoid" id="A0A194QNL5"/>
    <dbReference type="OMA" id="IPYPFYP"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="222" mass="25182" checksum="370C50AABCCB51A3" modified="2016-10-05" version="1">MSLGKQPAEHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEMEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKALVKKEPKFGFGISGLMAPVPRLLPPSLPHPVPQLPVPHHLLPDKPDLSRALFPPLPYPFYPFAKLPSDDGKLAAELAHLQALYGGALYSSAFYSNALSPCGCPPRRSPSPPPDVKRPVAYVLMKSDEEPPQHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPL2</accession>
    <name>A0A194QPL2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPL2"/>
    <dbReference type="FunCoup" id="A0A194QPL2">
        <property type="interactions" value="1633"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPL2"/>
    <dbReference type="KEGG" id="pmac:106719428"/>
    <dbReference type="InParanoid" id="A0A194QPL2"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021952">
        <property type="term" value="P:central nervous system projection neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="598" mass="69293" checksum="CC7EC433CF1BE4E8" modified="2016-10-05" version="1">MIVTENMTAKEIINDFKENYGKVRKLLDEDSKNDPENEPYASKYKAKAILLNMYVSLPTISQSQSEDSIDKVKLDAMMGTVLLNIGIIDMETEELTASENVLVEAEKLLTPNATKPEVVRTLINVYNHLGILWSNRGEQEKAKEYLVKAKDLYENFKCTLQIPLAIEQIINNAGETTADDFLLFEKAHTLTLYYLAQVFWALKQNLKAAIYYYVTLRRQLQYSDYEPIDWALNSATLSQYFAEQNGFFQSRHLLAASSTILEQHEQNLQAVESNEDAHLAKVETFKHRSADVARCWAKYCLLLMSASKSRLMDDAERLEDAITDMSNLNLEDTENICGGDIKNLNFPELDVSKYENKVTDKFLLMYQDAREVFLNCQSWLNKAKEYYKLDSLASDYIKLTQDSSQSYSYLAFFEEDDERRAKMHKRRVDMLEELVKEINPVYYLQYCRQLWYELGEVYSEILNIKLDKVNKTSEKPTPHALKKINMLCEKSIENYDHFLNSIKDKNGKLPQKLEYDVIRPVVSAYAYMGRNSMKRIALDKAMQLNNVKKSYESYQAVVDICKSDEEAASMMKEEYSLCKEMVQILPIKIKKLETELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ26</accession>
    <name>A0A194QQ26_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461191">
        <property type="protein sequence ID" value="KPJ07070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ26"/>
    <dbReference type="InParanoid" id="A0A194QQ26"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7265" checksum="C412DC0BDADB9C43" modified="2016-10-05" version="1">MKPCDDGQVIRAQSLYPEVGVWRAAHFPQRMTSARGRGQWRDGVTPLSPHSIRTFLRAGACASGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQT1</accession>
    <name>A0A194QQT1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQT1"/>
    <dbReference type="STRING" id="76193.A0A194QQT1"/>
    <dbReference type="InParanoid" id="A0A194QQT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MADF" evidence="10">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1134" mass="132099" checksum="3A8539F8AD66DBE7" modified="2016-10-05" version="1">MEWEWTKDKTLKLIELLQVNASLWNPSLCDTRREKQKRKEELRAIADILGISVPDTTKKIQHLRTQYNRESAKEARVNAEDPNDRYVSNWYAYEYLHFMKDSSKVYKILQSVELTDTIASQNETTAALTDCKLFNLSPPHKVPRTEILHPVKSEIIHQSSPRDRDEFSVFGEYIANELRSLKVGLSSGVENDTIVLKSKQCKKFEPYWANLDTRILPQWYDEAKIGIFVHWGIYSVPGFSEWFWNNWEEKEMVIQKFMKNYFAPGFTYQDFAPMFKAEFFDPNQWAHLFMKAGVRYVVLTSKHHDGFCLFPSQRSFSWNSCEVGPKLDVVSELSNAVKQVGLKFGVYHSLFEWFNPMYKEDKKNNFKTLYYPNMKLWPELKQLVNDYKPSLLWADGDWEAYDTYWRSTDFLAWLYNESPVKDVIVVNDRWGKGTSCKHGDFYNCHDHYNPGKLQPHKWENAFTVDKKSWGFRKTMNSNETMTMKEILHEIVTSVSCGGNVLINVGPTQYGTIPPIFQDRLLKLGNWLEINGKAIYGTSPWHHQNDAINSDVWYTCHKTPYNVLHPTAKPLITDTISGIFAIFLTWPLSNRLILKDVTGYIQSSVYEIELLGNDGDLSVSIREIKNGITYVKLPDKATVVVEYAWVLRFTPKIMKLILLCILVLYSVVRSYSKLESGESRHISGHRVSKKYSPDWKDLDTRPLPHWYDDAKIGIFLHWGVYSVVGFSEWFWSNWKGGDKKIIKFMREHYPPDFTYQDFAPMFKAEFFDPSEWADLFLKSGARYIVLTSKHHDGFTMFPSHRSYSWNSYDVGPKRDIVGELSNAVRAAGLKFGVYHSLYEWFNPIYEADKKNNFTTRYYAETKLWPDLKQLINDYKPSVLWSDGDWETYDTYWKSTDFLAWLYNESPVRDEIVVNDRWGIGIPCKHGDFYNCADRYNPGSLQNHKWENAFTVDSRSWGFRKPMTLNDTLSTEQLLYQVVSTVSCGGNVLINVGPTQDGTISPIFQERLLDLGSWLKINGEAIYSTSPWLHQNDSLNQDVWYTCRKAKHSHRHPTAIPKETDNVTAIYAIFLNWPTTNILLVKDLSTYLHNGVYKIELLGNEGLINWNIKNGVTSIELPDKVKVRSQNAWTLKMSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTN4</accession>
    <name>A0A194QTN4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosaminoglycan xylosylkinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTN4"/>
    <dbReference type="FunCoup" id="A0A194QTN4">
        <property type="interactions" value="1329"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTN4"/>
    <dbReference type="InParanoid" id="A0A194QTN4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="307"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="509" mass="58282" checksum="71A94E79B6534CC9" modified="2016-10-05" version="1">MLDRRIHLRNPTAEFYSPAVLKGYRLDFNLYVPSWRGAAATIVTDPGSSVWGAVWIIERKQMYRLDEQEGVNLRWYIPINVTVTTPQGRDHIARTYRESILLPKLSEGETLPPARRPSNTYLQEHMKLDYLRNTSDIFTHSPQTGGLPIAIYEINSAILSMSLYDALRVILITGTNSKDVLYETEKWVSDESLFPHTNGAPGQILRAIQNSQIALVDNAPKGTQLKLLLLLEGKQKLYFKPKRYELDNVIKGKIYAGYDRHNSEVFAYYLAMVLNFKWIAPSVIRKIHIERDVVPKATLALNKTMLKSESGSTCIYGKCFYCKRNETVCPDQNGEIEGAAILYLDRQFKIHKSPWRRSYTTKKMEWEENNNFCKKVTATLSLKRILNLIDVAIFDFLIQNGDRHRYEVYKDQIVLLDNGKGLGNPSVDELDILAPLYQCCMLSLKTWQNLELLSGGSLSETIELLAGYQGNKLATEEHFRAVDRRLMKIYATVQYCIGKYGSTKVLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTU9</accession>
    <name>A0A194QTU9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">28S ribosomal protein S28, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTU9"/>
    <dbReference type="FunCoup" id="A0A194QTU9">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QTU9"/>
    <dbReference type="InParanoid" id="A0A194QTU9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019375">
        <property type="entry name" value="Ribosomal_bS1m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10246">
        <property type="entry name" value="MRP-S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="15138" checksum="92EE38DFC2C240B2" modified="2016-10-05" version="1">MLINLGLRQCAKYSNILKIPRRFCSVTTTPNENTDNTADLKTGGFAKAYEKQSQILKQEDNQDFTFPALLRNSKLIDLGDPVGKIVIGKIFHVVNDDLYIDFGWKFHCVCTRPTTRGEEYVRGARVRIQISDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUM8</accession>
    <name>A0A194QUM8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_15374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUM8"/>
    <dbReference type="InParanoid" id="A0A194QUM8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ09233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="136" mass="15189" checksum="69856AAEEDC71978" modified="2016-10-05" version="1">MESITQDTLGVKSIPPWSGFRQGKPLPGARSAACSYPLRSMRCFIVVLFLAMLTPSMSRPYDPEDDELKSVLSTNGNFEAFYPRQAHGIPNGSSRPAHGHGSFYKHRNPALVDVKNAAAYGFRFDGMRRFNFDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN0</accession>
    <name>A0A194QUN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN0"/>
    <dbReference type="InParanoid" id="A0A194QUN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="126" mass="13146" checksum="3CF11D92D9EC3C97" modified="2016-10-05" version="1">MGALKRAGYDTSGPGARHSSPLNLEQFIPSPKPSTCYHDLESAAPMFAGMRGVHQQMLSGGTLTATSISGLGSFGHHLTTSLPTLPPDRKPSTPISGLGPPPTSLPTPVPPPSTSTTVHSYYDHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUS6</accession>
    <name>A0A194QUS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUS6"/>
    <dbReference type="InParanoid" id="A0A194QUS6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="309" mass="35164" checksum="A1F5CFC4354A9006" modified="2016-10-05" version="1">MKWVPFLALLLLCSTYLVRWIASSRVYFLGWGSPSSVSIGTGPPLVEEKSNKRRKRQKARKEDSRDVKRLKEKRAYATLVASSTRDLPIPLVVVPEITLQISKRTQRGDVVRHHSAHDLFKPLKRVKEKRATNQLICATKYKSRTGRQFNTRSTHTTYGGALKCLELLNNLSIEASVLHETPDKNAIHINTATKGFRILESLQLFKESHSQVIDLRELQIKANHLKHLQEGNKRQMNVEESGNWKRRKTSRDDDTEDDQENEQEEGEGTQGDVNGDKAPNEGPVLTSGRNFRLVSEKVRATSCDLKITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUX1</accession>
    <name>A0A194QUX1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Disco-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_15255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QUX1">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUX1"/>
    <dbReference type="InParanoid" id="A0A194QUX1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="296"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="5">
        <location>
            <begin position="772"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="892"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="1390"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ09114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1501" mass="163219" checksum="0C53524784C4C578" modified="2016-10-05" version="1">MRSPLTEVRQEAVQQALAEMQNRPKPSLPMPSKRTSMMAKSPDRERHDLSSSSDEDSCAGDNELPPPPEMGSPPARRPAAPHPRALPHPLPQPHHLRDKKHAPKERTEIDLSEISAHLPAYVQPDVTHTTSGARRGGALVADRVQCYTQPEDTGTGTGRWKVSAKIQQLLNTLKRPKRRPLPEFYEDDDIELEIAANPKDPNAPKPEGGTMTPAVGEQLVVPAGLPRNLEAALQRYGTASFKANVATVLDPNGKLSNSLTYGKLLSRSFKIAYALLNKTFTSKSTSGGPMTGDNSIKLGDRVALVYPNNDPINFMCAFYGCLQAGVVPVPIEVPLTRRDAGLQQVGFLLGSCGIQYALTSDACLKGLPKTSSGDVVSFRGWPSLHWVSTEKLPRPPRDWIPPPRPAEDSPAHIEHTSAADGSAMGVIVTRASMLSHSRMLSVACNYTEGEHMVCVLDFKRETGLWHAVLASVLNGMHVIFIPYALMKVSPASWMHMITKYRASVAIVKSRDLHWGLLATRDHKEISLSSLRMLLVADGANPWSLSSCDQFLSVFQSKGVRGDAICPCACSSESLTVCVRRAGRGGSSAGRGVLSMSGLSYGVVRVDAENSLTSLTLQDCGQVMPSCVIVVVKIEGPTYLCKTDEVGEICVLCGATGSGYWGLPGLTNTVFRVRPLDADGEPIGEEHYVRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKHNMDDIIATVLAVEPMKFIYRGRIAVFSVRVLRDERICIIAEQRPDCGEEESFQWMSRVLQAVDSIHQVGIYCLALVQPNYLPKTPLGGIHLSECKRRFLEGTLHPANVLMCPHTCVTNLPKPREIHSDVGPASVIVGNLVQGNRLASAQGRDMGYTDDSDAARKYQFISQILRWRAQSTSDHVIFTLLNSKGAVSKVLTCAELHKKAERIGNLLLEKGRVNTGDHVALIFPPGLDLISAFYGCLYVGAVPVTIRPPHPQNLHTTLPTVRMIVDVSKATLILSNQSVIKLLRSKEASNVLDSKAWPITLDTDDMPKKKLPILYRAPTAEMLAYLDFSVSTTGMLAGIKMSHAAVTSLCRSMKIACELYPSRHIALCLDPYCGLGFALWCLSSIYSGHHSILIPPSEVEINPALWLSAVSQYKVRDTFCSYGVMELCTKGLGSSVNQLKSKGINLACVRTCVVVAEERPRINLTNSFSKLFSALGLSPRAVSTSFGCRVNIAICLQGASSPEPSTVYVDLRALRNDRVSLVERGSPHSLCLMESGKLLPGVKVITANPETKGQCGDSHLGEIWVQSPHNASGYFTIYGDESDYADHFSAQLVTGNTGEVYARTGYLGFLRRTEISATGTSCEESMMARDSDTDSLASACGSVGMGADTHDTHDAVFVVGALDETIMLRGMRYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNDSEALNLVPLVTNTVLEEHHLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLSDQIDAIYIAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVP0</accession>
    <name>A0A194QVP0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide exchange factor DBS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461103">
        <property type="protein sequence ID" value="KPJ09389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVP0"/>
    <dbReference type="STRING" id="76193.A0A194QVP0"/>
    <dbReference type="InParanoid" id="A0A194QVP0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264658" evidence="2">
        <location>
            <begin position="19"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ09389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="560" mass="63627" checksum="E1077CF64045B009" modified="2016-10-05" version="1">MKSIVLFVIARRVADACARVWSMCREYCLVTGLMKLKAECDGCGSEGEEGRSVGELLLPQYALATGGLARDHRPLITFPDNSNFHLLSPAEYRRLLLYLTSVPSLLEAEMGFHIIIDRRKDRWNSVKTVLIRISEFFPGMIHSVYVLRPASFLQKALSEVSSKLFKEEFRFRVLVCSCIEELYEHFDRSQLTPDLGGELQYSHSEWIQQRIALEKFSTLMKEISTKLDDFMHEIVDCDMGNDPTQTKELLDCQETRYKALKTELSTATTQGEELLTQVRKPNLTYNIISHVAAVERLLVQLDETEKQFDNFWQKHSTKLNHWLKFRTFLLNFKQMQATLDNHLKTACDMTEVGETASRVESLIQEANDFEKLCNCDLDTASQLLTTTLMKDPLSSVDHIESKCEELRRTSALLIDKIQKRNLLLTKARELMDRIDKANEWCATGVEILAGEGGLIAVDKLLEDAKSFGLTAPEEFRDMLLQSATQETRALVAQVAQRVEDVWLMVSVKRASLQRAAARPARPVQSVPPQTAALPLPLPLPVLQVSRLNNSNKCPTLNESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QW43</accession>
    <name>A0A194QW43_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleiotrophin/Midkine C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_15326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pleiotrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QW43"/>
    <dbReference type="InParanoid" id="A0A194QW43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048332">
        <property type="term" value="P:mesoderm morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.90.10:FF:000001">
        <property type="entry name" value="Pleiotrophin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.90.10">
        <property type="entry name" value="Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020090">
        <property type="entry name" value="PTN/MK_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038130">
        <property type="entry name" value="PTN/MK_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050:SF1">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01091">
        <property type="entry name" value="PTN_MK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264684" description="Pleiotrophin/Midkine C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine C-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="19067" checksum="137E3FB41DED924E" modified="2016-10-05" version="1">MVAGLILLLVAIASAEGEVLENGDHEAVIRNERGAKSRETCRYVRGAWSECDSKTNIRSRTLTLKKGDVSNCERTKTIQKKCKKACRYEKSSWSECSANGEMSRTDMLKANSDPTCDQSRRITKKCNKNKQVKSTKDKDILVALKFALIAAQTTITFRCVVAWRDAGEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXR8</accession>
    <name>A0A194QXR8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460953">
        <property type="protein sequence ID" value="KPJ10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXR8"/>
    <dbReference type="FunCoup" id="A0A194QXR8">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXR8"/>
    <dbReference type="KEGG" id="pmac:106715918"/>
    <dbReference type="InParanoid" id="A0A194QXR8"/>
    <dbReference type="OrthoDB" id="9923602at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012575">
        <property type="entry name" value="NDUB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08040">
        <property type="entry name" value="NADH_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="57" mass="6421" checksum="931A3DBDDB365D0E" modified="2016-10-05" version="1">MAIFGITGRYIYVAIPLTGFFIGKFLDDQETLRMTSFRDKSCLYGGNVKDGDPPTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZM4</accession>
    <name>A0A194QZM4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZM4"/>
    <dbReference type="STRING" id="76193.A0A194QZM4"/>
    <dbReference type="KEGG" id="pmac:106717204"/>
    <dbReference type="InParanoid" id="A0A194QZM4"/>
    <dbReference type="OMA" id="PSRFFLT"/>
    <dbReference type="OrthoDB" id="6080988at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="120" mass="13343" checksum="F6A4237E35FE7F54" modified="2016-10-05" version="1">MPCLKILTNISSYKIPRDFVDKIIPVLAKAVKKDVNKFICVITGDCQMSFGGESSEPSAIATLESIGNLGPKENREIVRELSKYLEKELKVKPDRFFLTFYDLLPYNVAKGGVTVEEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZZ4</accession>
    <name>A0A194QZZ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZZ4"/>
    <dbReference type="InParanoid" id="A0A194QZZ4"/>
    <dbReference type="OrthoDB" id="7138239at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264772" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="11224" checksum="46D396764AE43829" modified="2016-10-05" version="1">MAHTTIFLSILLLSFFANTICKIVLPHKLRYLENMLNAEVIAKAAKLRQRMEANPNIQDSEKNWPILLAKFQTDEKYKKLAPYSYNNIYGRRIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R036</accession>
    <name>A0A194R036_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R036"/>
    <dbReference type="STRING" id="76193.A0A194R036"/>
    <dbReference type="KEGG" id="pmac:106717011"/>
    <dbReference type="InParanoid" id="A0A194R036"/>
    <dbReference type="OMA" id="CTAGEGN"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="257" mass="29894" checksum="BD28D7D284FAD8A4" modified="2016-10-05" version="1">MNIQRLMLLKYKPRYLTHKVLFGTHTETCPEYMKQFDKPKNGALKRAEKSGKVRLGFIPEEFFVFFYPKTGITGPYLFGIMALNYLVSKEIYVMEHEYYIGLSVLVIACYSTKKFGSLVAASLDKEVEKVEASYNLGRKEEESNYETVIKNAKTAQWRANGQKMLIDAKKENVAMQLEACYRERLMHVYNSVKRRLEYHAKLTRIETNIHQKWMCAWILDNVLKSITPEIENKIIVKAIEDLAKLSAHSGNKQIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0C6</accession>
    <name>A0A194R0C6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [acceptor]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_14791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0C6"/>
    <dbReference type="FunCoup" id="A0A194R0C6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0C6"/>
    <dbReference type="KEGG" id="pmac:106714831"/>
    <dbReference type="InParanoid" id="A0A194R0C6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264789" evidence="5">
        <location>
            <begin position="20"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="702" mass="78425" checksum="726D14D6780B97D2" modified="2016-10-05" version="1">MNKILWITFVTIYISYVQSAVIDKDEFVTVEDNPYQNVNEIANPDVESARNERILWPYVAESTTKPENEENKTDEKDIKDVKPREKRFLHWSYPQSPIVDMMMQTMSVNYSPNVAGDPFDFLRDSYQLPEGKMLEEYDYIIVGAGTSGSVLAARLTEGKPKATVLLLEAGKPEMLLSDIPALAPYIKLTHYVWPYTMEHQPGVCLGSEEQRCYSPQGKAVGGSSVVNDMIYSRGRPQDWDRIAADGNYGWSYDEILPYYKKSERCELRKYKNATYSGRDGELTVENVPFRTGLVEAFLAAGRLHGNPTIDYNAPDQLGFGYVQTTQNRGHRLSAAKAFLHPHKRRKNLHILTDAKVTKVVIEPQTKRAYAVEYLKNHIKHTARCRREIILAAGSVGSPQLLMLSGIGPKEKLDVLGIPVISDLRVGKSLYDHIAFPGIVFKLNSNNASLQELKVATLPNLMQWLQFGDGLMTTPGLVEAVGFIKTSHSDGQLPDVELLNLGGSIVSDNGGAFRKSLKISDKTYVTAFSGLHGCDTWSAVPILLHPKSKGYLELRDNNPFSHPKLYGNYFTDPQDMETMKEAVKYVIKLGESEPFKKYGAQLYLPPYPNCQNHGPGSDLYWECAIRTMVVSLHHHVGACKMGPPNDPEAIVDPELRVYGVDGLRVVDLSVLPHTISGHMTAPALMIGEKAADMIKKIWSNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1F1</accession>
    <name>A0A194R1F1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_08365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1F1"/>
    <dbReference type="FunCoup" id="A0A194R1F1">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R1F1"/>
    <dbReference type="InParanoid" id="A0A194R1F1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="119"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="360" mass="41100" checksum="4C9121817EF4BDBE" modified="2016-10-05" version="1">MEVGSELANLLKNNSSDNNIEKLKIQSSLLKENIKKLKVPFWSAEEAAIVEALKLPNVLHPKTPSQKNKVLFTYKTVSDNDKDHLKIGKDNNLIQFTNKENYYLKGDAAVFELGAKFYFSKSLKDTGFIQFSNPDFVKSLIIEGCGHDHTDPNHTFIIHHNEDSKVNVDNRLHLTGGGSLFSFFAYYTKNVLHSNALPLKYFSMGRQYNPVDNEEIGLFNVSQSSVISMFIATKNIEECDAILDETIEVIKNIYSNIGYPYRLSIVTAEKLHMWESLRVSIEMYSTSLKSYIEIGNISVSGDFISKRLMFNYTHEKQNKYPHIISGTILNVPMFLGCVLEQNTEFSIPQEFTVNNWCFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1L8</accession>
    <name>A0A194R1L8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1L8"/>
    <dbReference type="InParanoid" id="A0A194R1L8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="35752" checksum="9B5D8F3FBC791FEB" modified="2016-10-05" version="1">MDYSVEEGLLPREAIEFDFAEDALDYEMVCGGRCGCGAFCRRIFCRSRSRSGSVNGDSSPITLTHLDEARDVKFTQTLTEPLSIGSHITCTGTPTEDLPWFAINIGCGDPESRGDIAVHFNVRLPQNYVVRNTRRHDKWGPEETTAFRLFPFKVNRPFTIEVLVDEKETLWAVDGEHYCSFAHRSPSPLGAGWVQVIGIRDTDLKIHKTDIYPTTGPPVFDIPMRESAANPRQQDEPIWRPNIIAKLPNGIPEGYQLTTIRIVRGPGEWSVYTDNVLIGEMEYRASPDGVKAMRIRGDIYPEDIYVSPSTSSPIQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2D5</accession>
    <name>A0A194R2D5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tachykinin-like peptides receptor 99D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15049</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2D5"/>
    <dbReference type="InParanoid" id="A0A194R2D5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="42"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="475" mass="54814" checksum="2CB3EB881E14DDC8" modified="2016-10-05" version="1">MEEYLIQNGTNDTYDTLYDVPTGLIVLLSVLYGSISMLAVVGNFLVMWVVATSRRMQSVTNCYIANLALADIVIGLFAIPFQFQAALLQRWLLPHFMCAFCPFVQALSVNVSVFTLTAIAVDRHRAIITPLSAHTSKRIAKVIIVFIWVLALSLAAPMAMSWEVIMEQEIDPVTGLMYKKPFCTASEFGSHSLAIYRLLLYIFQYVIPLCVITFAYAHMAMKLWGARAPGNAQETRDANQMKNKKRVIKMLVLVVALFALCWLPLQSYMLLQSFFPSINEYRYINVIFFCFDWLAMSNSCYNPFIYAIYNEKFKKEFKQRFTLRQKRNRYHNDSYEDGQSYRTRVLSFRSTNERSSYYARKSITFAPTDAVKSQTRNSCHCARNSNVNLEGESRQNVAGDRDNYRNGTNKNGFKIDTSMRRNKSKRVTKDDTLPVGDERLAQTQTNQNELIQELKWNGKLNELKIRFERLEILRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2W0</accession>
    <name>A0A194R2W0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_08322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2W0"/>
    <dbReference type="STRING" id="76193.A0A194R2W0"/>
    <dbReference type="InParanoid" id="A0A194R2W0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443735" evidence="6">
        <location>
            <begin position="22"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="344"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="541" mass="60633" checksum="475769591C7D0DCD" modified="2016-10-05" version="1">MRLILFVCTLLWNSVEYFVNGVPFIDGTYRLDIIHYNDFHDRFEETTISYPVCESNDENCMGGFARLYYEINTLLKEKENPILLNAGDTFQGTYWYTLMKWNITQKFINLLPNDVHTVGNHEFDDGIAGLAPYLAALKAPVVVANIDTTAVPELDGLYKPHIVLEKKGKEIGIIGLITPETKTSSNPGKVKFLDPIATVKKEAQLLTDQGIDIIIVLSHCGLEVDKKMAEVAGENIDLIVGGHSHSLLWNGEAPNKEQVSGPYPVVVKSSENPKHEVLIVTASAFSKYLGNMTMFFDRSGELVSYSATPVFLNRSIPEDPEMKALLKPYTEKLHSLVKEVLGYANEDLLAPKCGSGECAIGNFIADAFLEATKELKVSNLTHVAFIFRNMIRGSLAKGEITRGSIINTMPFTNQVVTMSLPGRYLIDIFKTCMTNYWVAKPFSGPWMPHVGGLRLKINLTKGIDVQVQVKEGEVYQDLELDREYQVSTIEFLVRPGNQFEELSRYGRNVQVVGKDTELLEHYIKKTSPIEPILEKRLTVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R4B0</accession>
    <name>A0A194R4B0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein FAM195A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R4B0"/>
    <dbReference type="STRING" id="76193.A0A194R4B0"/>
    <dbReference type="KEGG" id="pmac:106713779"/>
    <dbReference type="InParanoid" id="A0A194R4B0"/>
    <dbReference type="OMA" id="FNLEEWW"/>
    <dbReference type="OrthoDB" id="8170061at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14799">
        <property type="entry name" value="FAM195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14168" checksum="362D5B726D466514" modified="2016-10-05" version="1">MDRNMRSSYVNSGPRSLPHMGGGKRQNINGHNGARLSPPAQMPPGQLHNNNNNNNQHDDLINYIYDSWNKVTRELERGSDDARYYQEVLAPRQLANFRPFNLEEWWGRRLVQTINRNKHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R557</accession>
    <name>A0A194R557_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R557"/>
    <dbReference type="FunCoup" id="A0A194R557">
        <property type="interactions" value="1002"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R557"/>
    <dbReference type="InParanoid" id="A0A194R557"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.850:FF:000001">
        <property type="entry name" value="Isochorismatase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF17">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="199" mass="22195" checksum="C32A4C452F144082" modified="2016-10-05" version="1">MARNILKLGALEAQKTAFLLCDIQETFRPHIKHFGEVVKVANKMVAAAKVFKIPVYVSEQYPKGLGHTTKDINISDAALVYEKTKFSMFTPELQEKLKKDVPNLSSVILFGIEAHVCIEQTVIDLLNEDINVHVLADGVSSRSLMDRGLALQRFQSIGCFVGTSENVLFKLLRDKNNPAFKEISKLNLKPTPDEFGMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7K0</accession>
    <name>A0A194R7K0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peripheral plasma membrane protein CASK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460647">
        <property type="protein sequence ID" value="KPJ13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7K0"/>
    <dbReference type="STRING" id="76193.A0A194R7K0"/>
    <dbReference type="InParanoid" id="A0A194R7K0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="217"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="390" mass="43942" checksum="440FA02C5848C756" modified="2016-10-05" version="1">MGITLKLADDGRCIVARIMHGGMIHRQATLHVGDEIREINGTPVANQSVAQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQFDYDPLEDELIPCAQAGIAFNTGDILQIISKDDSHWWQARKDAAGGSAGLVPSPELQEWRAACAAAERSNADQGTEGCVSHTDGCENTVNCSIFGRKKKQSKDKYLAKHNAVFDQLDVVTYEEVVKLPSFQRKTIVLLGAHGVGRRHIKNTLIARHPDQYAYPIPHTTRPPRPDEENGRHYYFVTHEEMMADIAANEYLEYGTHEDAMYGTKLETIRRIHAERRVAILDVEPQALKVLRSAEFAPYYDGSLEVLVRESEQLRRTYGHHFDLCIVNNDIDDTLAQLEAALVRLRTSPQWVPVAWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7S1</accession>
    <name>A0A194R7S1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basic juvenile hormone-suppressible protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_08697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7S1"/>
    <dbReference type="FunCoup" id="A0A194R7S1">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7S1"/>
    <dbReference type="InParanoid" id="A0A194R7S1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264977" evidence="3">
        <location>
            <begin position="18"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="158"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="749" mass="89195" checksum="D25AC9A6A10BB201" modified="2016-10-05" version="1">MKSIAFLVLGLAALAAARPEVDDHRFVDMDIKQRQMFILKLLNHITEPVMYKDIQEIGMNFKIEENVDLYTRTDVVKTFVNFVKIGLLPRGEIFTIHVDRQLKEVVSMFHLLYYAKDFTTFIKTACWMRLYLNEGMFVYALTVAVRHREDCKGIILPPPYEIYPYYFVRADVIQKAYLLKMKKGLIDAKLCDFYGIKKTDKDIYIIDENIFDKRVYLNDNDVLRYFTEDIDLNTYYYYFHVDYPFWMRDELFDKLKVRRWELNFYVCQQILARYYLERLSNGLGEITTLTWNMPVRKGYWPWMLLHNGVQFPLRPNNYVLVGDKDINVVRLVENYEMIIKEAILKGYIDINGIRLDLFKADDIETLGKLVFGKIDKTQVDKFHIDAYRYLLIIMKSVMGLNTFNSDKYFVTPSVLDIYQTALRDPIFYQLQKRLCDLMILFKKRLPCYTRDELYFPGVKVDNVVVDKLVTYFDDYLMDMTNAVTYTDDEWKKTTSDMVFFVRKRRLNHQPFKVTLDIMSDKSVDCVVRMFLGPKEDQWGRLIDLNQNRINFVELDSFLYKLTTGKNTITRNSIDMHNLVRDRLMTRDLWKKIDTMTDMRDLLMKDLRNYHTGFPTRLLLPKGRVGGMNFLLYVIVTPLKLVDNVDLTILDNNRKDLLVDFRSTVLLDKMPLGFPFDRTIDYTKFFTPNMKFVDVVIFHKKQVCDMKTRWDRWVLKNYNMVDHTIVGNDNYMVDVDINTKVDRDVNLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7T1</accession>
    <name>A0A194R7T1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7T1"/>
    <dbReference type="FunCoup" id="A0A194R7T1">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7T1"/>
    <dbReference type="InParanoid" id="A0A194R7T1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046068">
        <property type="term" value="P:cGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000031">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000032">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="631"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="726"/>
            <end position="730"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118857" checksum="397AFA4E45D95F26" modified="2016-10-05" version="1">MGQTASMCRLHGSCLHHKKIDYSSAYAIIDKSARELPRKQFNDQFNTMIKSNTTFVPDATFLNTEQGREPKMAACLFSSLQLRSIEEPAGAGSAGGAGAGSGVPVSACYDAECARTEAWLDENQDFVHDYFLRKATRQVVDAWLVCHATPPSAELASPSRAGSGSGATTPVRKISAHEFERGGLLKPLVTTVDGTPTFLGDTPHAAPARPQRRSRHELRQLDEKELIFELVKDICNELEVRVLCHKILQNVSILLDADRGSLFLVQGEKVASPHPQNGRCLVSKLFDVCSKSTPEQMEQLEEIRIPWGSGIVGYVAESGEPVNIPDAYKDERFNHDIDQQTGYKTRSLLCMPIKDINGEVIGVAQVINKQSDGPFTANDEKVFASYLQFCGIGLRNAQLYERSQLEVKRNQVLLDLARMVFEEQSTIEHMVLRILTHTQSLIRCQRVQVLLVHEASKGSFSRVFDLEAGDETEPRTSPYESRFPINIGITGYVATTGETVNIADAYLDPRFDPSVDEDAGFKHNTILCMAIKNSEGRIIGVIQLVNKFDGLLFTKNDENFVEAFAIFCGMGIHNTHMYEKAITAMAKQSVTLDVLSYHASASIDDAQRLRTLRIPSSVHFKLHELEFDDIDLSDEDTLLACLRMFLDLDFVERFLDIDTLRIPSSVHFKLHELDFDDIDLSDEDTLLACLRMFLDLDFVERFLIEYGVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTETQWWKIFGELECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYERVVKVLEDAILSTDLAVYFSKRTAFIECVRSERSVGSAGSVGSAWGECGERRGLLRAMLMTACDLAAITKPWPVERRVAALVAGEFFRQGDLERHNLNLTPIDIMNRDKEDELPAMQVKFIDTICLPIYEAFAVLSPALQPLLDRVKSNRAHWIDLANNDKSCKFDYGMEKEKEERNDKSSASSHEDEHEDSSGAGSLSSDTNSKYEQLENPVVGLVSNNALMPREPKFCHLNELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8F5</accession>
    <name>A0A194R8F5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 8">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8F5"/>
    <dbReference type="FunCoup" id="A0A194R8F5">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8F5"/>
    <dbReference type="InParanoid" id="A0A194R8F5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="355" mass="39719" checksum="6CF9978216C6FC0E" modified="2016-10-05" version="1">MTGRHILQLYQKFLNKHPYLVQAIQTGALMGAGDYISQTLVEKKSVKNVDLVRTLRFSSIGFFAGKLRMDSLELVSSNKIFGGLQKVYTHESAELKCKMNFSIYLPPQAEGGDVKLPVIFYLSGLTCTEQNFITKSGFQRYAAEHGIIVVGPDTSPRGVKIPGDDESWDFGVSAGFYLDATKEPWSNNYRMGSYLNKELYDLILKAFDNVVDPGRIGIMGHSMGGHGALVSTLRNPGLYKSVSAFAPICNPTACPWGVKAFTGYLGDDENRWKEWDATELVKKYEGPPLTLFLDQGAADKFYIEKQLLPENLVKACRSVEVPVILNLREGYDHSYYYISTYIGEHFDFHAKILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8P3</accession>
    <name>A0A194R8P3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8P3"/>
    <dbReference type="FunCoup" id="A0A194R8P3">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8P3"/>
    <dbReference type="InParanoid" id="A0A194R8P3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="376" mass="43612" checksum="B4EFBC623130D9FE" modified="2016-10-05" version="1">MAHATVPKYRELKQPNREWPSSGESRQTGGPAFLPKFPAKLAGLSGYWVWQVGNPIYNVSSLEKEDGLPTQICDICLDNLSIAYNFKTLCLLSEKTLKSINNDTKEGILEDISGNTDEFKQDFQAEDNIQIKQEPGVNRRSTRVNLKLKIEGIEENEVTTKVRNKRGPYKKTGQTRLTKFKFRKLFCEPCGLKFANKEQSDKHKKETHKGESFICEICGKVFVHRASHFSHVRSHLPPQHACDSCDYRTWHKHDLVKHLRIHTGVKLYQCEHCTASYHTSSNLSCHIRRCHARERRHACHLCDRTFYDRTKLNRHIDSHNDIKRFECEVCHACFTRRCYWKKHLQRQHGVTVPPQRPGRQKTNRQVGELPPTGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R991</accession>
    <name>A0A194R991_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R991"/>
    <dbReference type="FunCoup" id="A0A194R991">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R991"/>
    <dbReference type="InParanoid" id="A0A194R991"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039151">
        <property type="entry name" value="INTU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082:SF4">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="5">
        <location>
            <begin position="265"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="6">
        <location>
            <begin position="455"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="7">
        <location>
            <begin position="765"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ14408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="905" mass="103486" checksum="AFE31E080A01D1FC" modified="2016-10-05" version="1">MNKFKNKVHYESPCDSDNDWTDSTGDSKYSDSESSVPEWDSDVGEDGELIFIKVKNNANDEVNAPLLENCETFKLRSDFKRASTRRSTKGRIFKALKSRKAKYDSTSGKINEYESTVSKNSLEDNNKFVIIQVSKNMIFNSEKNCQIEKLFGMSLETHMDGKTLIVANFLTEAKAIYIPRVKVGYYLLKINGIEVNSYNINNMLQRVIEDIESPKLTFQVVTGGFNIDLVKLLTLKNSPENSLTQLLKDSMCSVLYICCNDVEYQSNDDKGVLYCYPRPYNQNFLYNTRGAYVTLNHLAPKSLGTSEPVVSTVLYNNTLINVTYASHFTDLLLLAVPNKNLDLFCAKKLIGYVVKILEFLYGSLKSCFTKPNNVDKLDGLFSRIFVHLLFDNYKNASKEEGKVNTMLFEEFVACHAVTLPLEVKIQVDDAITELEAADYREWTDDVENFQRLYTVIGACLYYSGHLLSSHLRDEDLVEINAYLKFNSILRLSAEKELDKLVMWKEVFIKEHRSQNKNDRNENRIPDGRWFLLIVGKGHFILATLMEAGGCTEDAIGVTSPSPFYVEECESCLELLYEVGLHKYLASWFSSNTLPQVETTPEYLTKYGRKMKDTLKSDNLRTTTLKLSKSQPDLKRRHNSSDQINSGISSADNPINNYHSMSHHSLYHQWYNSSQKNYRHSSNLDISYSEDSNSLKSNSEISEERVTGRRADREQKARRDSSGSDSDWDRQDGSRTSGNIDMTDIRKSLLNELNNVAVHRITAGEENVLFHFVQLESEKGVLIAPMKTIEMQANNVLYSYIIASFKKACKKIHDLLQYSMKFKKNHAPSNPLNKILVAVREYGSLFEVPHEVLNQCGITKKNCEPFLFWVVGRVFSEPEPRELYICYHESVPQDLTEVALLLSYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAB0</accession>
    <name>A0A194RAB0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coagulation factor XI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAB0"/>
    <dbReference type="InParanoid" id="A0A194RAB0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="225"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="398" mass="44996" checksum="13D15E17592A0F37" modified="2016-10-05" version="1">MAHTGLTSSYILRPPGTATSRGGADDGASYTTKLTSPISEREFAKLHKEGLLESEDIECQFNGTVPVKCWRIIHDFTTLNFNEPPKCPELEKPYARSNLSPHQSVIYDVPVKCWRIIHDFTTLNFNEPPKCPELKKPYARSNLSPHQSVIYDACYAYSRLGSKCLVSETNKDVYYRDDCQRFRSDVKISDGEPAKFKEFPHLALTGCRKDPTKDITWIGVGSLISEYFILTAAHSAGNRDIVKFSDFIRPACLTFPGSKEYEYTACTVAGWGYMGMGERQGTSDVLRKATVYQEYNHNECTKSLLARYFDSTTMICIRSGEALPNQDTCQDQSGVHLMTMSNKYVRCSYFVAGVASWGPRCGLSFMAAYTNVSYDKYQEWIVENVWPLQLNAKKINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBG0</accession>
    <name>A0A194RBG0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein 82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBG0"/>
    <dbReference type="FunCoup" id="A0A194RBG0">
        <property type="interactions" value="2155"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBG0"/>
    <dbReference type="InParanoid" id="A0A194RBG0"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032785">
        <property type="term" value="P:negative regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000065">
        <property type="entry name" value="WD repeat-containing protein 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="314" mass="35182" checksum="29DE8A398C233831" modified="2016-10-05" version="1">MKLVDQVVRSFKVAKVFRENTDKINSIDFSPNGETLISCSEDDQIVIYDCEKGTQMITVNSKKYGVDLIHFTHAKNTAIHSSTKVDDTIRYLSLHDNKYIRYFPGHTKKVVTLCLSPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPVAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPFVTFKLNQEKECDWTGLKFSRDGKTMLISTNGSIIRLVDAYHGTPLQTFTGHLNNKGIPIEASFSPDSQYIFSGSTDGRVHVWNADTGYKVCVLNGDHPAPIQCVQFNPKFMMLASACTNMAFWLPTIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBP3</accession>
    <name>A0A194RBP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_09054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UQCC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBP3"/>
    <dbReference type="FunCoup" id="A0A194RBP3">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106710778"/>
    <dbReference type="InParanoid" id="A0A194RBP3"/>
    <dbReference type="OMA" id="YMKFLGC"/>
    <dbReference type="OrthoDB" id="6139781at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027858">
        <property type="entry name" value="BRAWNIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14990">
        <property type="entry name" value="DUF4516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="68" mass="7694" checksum="D9CB41638995E01D" modified="2016-10-05" version="1">MPAGVTWGQYISFSIAAMLSMLAGSQLVHQHYKPLVDLNKYINKELEHLPENLQGKIRSELKDEGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC47</accession>
    <name>A0A194RC47_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable deoxycytidylate deaminase</fullName>
            <ecNumber evidence="8">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Supplies the nucleotide substrate for thymidylate synthetase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dCMP + H2O + H(+) = dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="8"/>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC47"/>
    <dbReference type="STRING" id="76193.A0A194RC47"/>
    <dbReference type="InParanoid" id="A0A194RC47"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="177"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="39011" checksum="1700C09EEB2AE0E4" modified="2016-10-05" version="1">MDLTEETKKLSIIDENLQTKRTGYIDWQEYFMATAFLAAKRSKDPSFQVGACVVNRDNKIVGIGYNGMPIGCNDDEFPWGKNTPSPLDSKYLYVCHAEMNAIVNKNSADVKDCIIYVGLFPCNECAKIIIQSGITEVVYLSDKNGHKPTYIASKRMFDAAGVKYCENLQTKRTGYIDWQEYFMATAFLAAKRSKDPSFQVGACVVNRDNKIVGIGYNGMPIGCNDDEFPWGKNTPSPLDSKYLYDQDKQETSLSVGYYENLMGNLHKGEFGCIYIFPCNECAKIIIQSGITEVVYLSDKNGHKPTYIASKRMFDAAGVKYWQFKPKNDKIVINFTGIDWENMSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCL0</accession>
    <name>A0A194RCL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein Xfin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCL0"/>
    <dbReference type="FunCoup" id="A0A194RCL0">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106710328"/>
    <dbReference type="InParanoid" id="A0A194RCL0"/>
    <dbReference type="OMA" id="TCAICCI"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000111">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="578" mass="66640" checksum="283486C589847E56" modified="2016-10-05" version="1">MEDSYIIANFHALCRLCLTKSSLTISIFAAAPDEDLNMPLTSKIAECFEMQVDPNDGLPGRICYKCLFKVNKCSKFRLQCIQNEARLKQITNRVNEQDTSNSSDYSNYTYKNHEMVKPKPEDYIVEDSVVMVVDPSLDYDSSEEESENVEQPESEKNECENIQEGEPTTESFFKNVSMCQYCDQAFVSQEKCKEHEQNYHDPNMPYKCVECSLVFAERNQYVQHTKHVHQSDKPYHCPECEKCFGRRSDLRKHSVVHTGIRPFQCHYCLKSFSRNTNLSKHLRIHAGHKPHVCPMCPRSFVAKGDLQRHVLIHSGMKPYACSKCPLSFGRRDKLIKHELKHGPINSQIKRNESEIDQETHDMVVSINPFSNIMTSPTQLNPENSIGDYDFPSVPDHIVGESSFINHVRKNPPTPSKSMQGSPGKQKMMTNKNKPKNIKCHQCTKRFSSLDAYKTHVSVAHIGSRVFQCKVCFKKFSRKRELDRHTQTHIGMKPFSCNSCDKKFNSKEKLDNHEQTQECSVVNMPCIECGLTFKKKADLVAHIKSHFTDNFDDKLCMSEIKKETESDFQLDDNFYELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE15</accession>
    <name>A0A194RE15_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic cation transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE15"/>
    <dbReference type="STRING" id="76193.A0A194RE15"/>
    <dbReference type="InParanoid" id="A0A194RE15"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="403" mass="44888" checksum="0C546728DC5301A2" modified="2016-10-05" version="1">MLVSLPILGYISDRWGRKRALVLSCTLVGAIGSLKAFSVSYEMYVIVEFLETVAGASAFPAAYILTIELLGQDKRVLTTAFLGILLVLGGLSFALLAKTFQYWRTFILVVYPPSLLFLSYIYFLPESIRWLLSQNRKEEAVEIIMKAAKMNKVTLSDETLRQLQTEQKIKTPEEKKDLEEEKGLWIQVMNSPIIMTRLAICSWWWITCTFVFYGLAINSVSLAGDKYTNYMLVVSVEVIAVVNNALVLDRIGRKKTLLAAYVVCGISCVAITFVPKTMPWLATLLYLVGKIAITQAFSGIYMYTSELFPTHARHSLLGFCSMVGRIGSIVAPQMPLLAIYIDWLPSVLFGATALIAGGLMLTTPETLNTRLPDTIREAEHIAAAPRKQTPTNPQTQEIVTSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194REF7</accession>
    <name>A0A194REF7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_08223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460297">
        <property type="protein sequence ID" value="KPJ16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194REF7"/>
    <dbReference type="FunCoup" id="A0A194REF7">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194REF7"/>
    <dbReference type="KEGG" id="pmac:106709606"/>
    <dbReference type="InParanoid" id="A0A194REF7"/>
    <dbReference type="OrthoDB" id="6247992at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="162"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="28882" checksum="7C1D8417AFEEE3A6" modified="2016-10-05" version="1">MNLSIRPNFLRCNLIASLRKYATTSPEIEQNEQVLIDDTDDVQAREAEIEKKRNKSKLSPAHYNLINGRRPYEIPKSTAHLTVKYNRKMYGIYGVSSGVNPSLCWPTKAEIQEKQEYEAVAYPYTIREMIDAAAARRKEEQARIEERDKAVAANFEKLDQWKKELNAKIAKKTAEVQAAKLKKERLVEEVRRHFGFTLDPRDERFQEMLAKREKEQRKKEKQARMEAKEKAMIAKLQQKNVELNEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RES1</accession>
    <name>A0A194RES1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_10005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RES1"/>
    <dbReference type="STRING" id="76193.A0A194RES1"/>
    <dbReference type="InParanoid" id="A0A194RES1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="240"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="354"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ15959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="459" mass="51277" checksum="36AF9123808DE2D7" modified="2016-10-05" version="1">MAAPRRVLVIYTGGTFGMLKNEKGVLVPQKNIEKVIRGLPQLHDNEYWKKHLANTEMKEYLAIPDGKDTEQKIFYKIHEYDELKDSSDFTIDDWLKMVRDIKRFYHEYDGFVVLHGTDTTAYGASVLSFMLEVVGKTVVLTGAQVPIFQPRSDGNNNFLCAVLIAATQYIPEVTVFFGAKLFRGCRVKKVSNTRIYAFDSPNFPPLLEAKTTLDIDSRMLIHPRGSVPDVCRIHDELSTKVYVLKVAPTITPELIRAVFNGMEGVVLETYGNGNIPIKRKEIYKEIEHAVKNNVLVVNVTQCINGTVLGKAIYETGLLLVECGVVPAFDMTAEAALAKLSYVLTKTELSYAEKVETYGNGNIPIKRKEIYKEIERAVKNNVLVVNVTQCINGTVLGKAIYETGLLLVECGVVPAFDMTAEAALAKLSYVLTKTELSYAEKVELMKTNIRGELYNPAHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RES8</accession>
    <name>A0A194RES8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RES8"/>
    <dbReference type="InParanoid" id="A0A194RES8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="7940" checksum="C63B33EF7E5D753F" modified="2016-10-05" version="1">MAPGDPYEREQKRLLELFNEAETPESSEDPYADDGEYGSDKDYHPSGDDSLSSIGVLSLNNILHATALTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGN2</accession>
    <name>A0A194RGN2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGN2"/>
    <dbReference type="KEGG" id="pmac:106710768"/>
    <dbReference type="InParanoid" id="A0A194RGN2"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="283" mass="30645" checksum="C5D2E218BE16ADA3" modified="2016-10-05" version="1">MSALKIESEVKVESEPCVVAWDNNTLFVGTETGTIFSYDKNLSPGGKWTAHETQVFALTAANGNVYSSSNDGGVRVWSAKGDKVAELPPTGGDIGALCVQDNQLIAGDESGNVVIYENNDVKAKYQVLEEVKDICLKTPYMFTARDLYVTVTEIKPEESKTRFTTRHTMEGRAPMRVAGARLVVTARGANNLQLHDASIDTKFKKLHEVKVSDMILTSLSVSEDHAWTGGWDGIVRRWNIVGDQFQPAGEVNLGACVNAVVATKSDVAYAIITGGRVVCLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGV3</accession>
    <name>A0A194RGV3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGV3"/>
    <dbReference type="STRING" id="76193.A0A194RGV3"/>
    <dbReference type="InParanoid" id="A0A194RGV3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685:SF2">
        <property type="entry name" value="825-OAK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685">
        <property type="entry name" value="825-OAK-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265184" evidence="1">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="465" mass="46564" checksum="8CF6CBA866B78FEC" modified="2016-10-05" version="1">MLIMLVQVLFLATIAMAAAKPSVVPAAVVAPAPLVAAPAPVVTASSSQYIARNYNGVVAAPLVAAPAPYVAPAARFVAPAAPLVSAPLYARYAAPYVAAPYAAAPYVAAPLVILLVTIAMATAKPSVVPAAVVAPAPLVAAPAPVVTASSSQYIARNYNGLVAAPLVAAPAPYLAPAARFVAPAAPLVSAAAPLYARYATPYVAAPYAAAPYVAAPAPILITSFAVIASCRASGIGHLVPAVKSIPIVRYAPFYNFPNGVRSIHAVAPPAPAFAPALPAPAPLLPAPLAAPLPPPVLPAPFLPAPTPVLPAPAFAPAPALPAPAFVQAPAPVLPAPAFAPAPAPAFAPAYAPAFRVIAQAPPVISPVLPKIAPAVPALPPVPVVGPTQFYRAVPSLPAVPFSPIVRPVATALPAPYFNPAVASAPVAVARAPIALPYASHFPHYAKYFSPAPVFSAPIVKQVAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH39</accession>
    <name>A0A194RH39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MFS-type transporter C19orf28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH39"/>
    <dbReference type="STRING" id="76193.A0A194RH39"/>
    <dbReference type="InParanoid" id="A0A194RH39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="357" mass="39820" checksum="92B052DC8702DF62" modified="2016-10-05" version="1">MLIGQVVDALATPFVGYHSDHTDNYLSAKYGKRKLWHLFGTVCVLLSFPFIFMDCIGCSMAHKWAQMYYFASFILIFQIGWAAVQISHLSLIPELAEDPHVRTHLTAIRFGFTVFSNLFVYIITWIVLHMTGECDKEQVGPRDAWKFRHIVYIVLGVGTVASVLFHIFVSEGRGLRQQQPLIDYNDNNRVHFSIFRKGILYQVASIYMSTRLVVNISQVFIRGRSRGTLNRSELKLADYCTHIVLGFGGSQMLVTSLSLTADLVGDRTEASAFVYGLMSFTDKLSCGAVIAIIQLYADGASSDYYRSVLSWVCGGATVLGLICTLTTPKLTPDPQVTDDNNPSINTIEETGPPTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH44</accession>
    <name>A0A194RH44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidate phosphatase LPIN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH44"/>
    <dbReference type="FunCoup" id="A0A194RH44">
        <property type="interactions" value="847"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RH44"/>
    <dbReference type="InParanoid" id="A0A194RH44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="2">
        <location>
            <begin position="446"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="663" mass="73419" checksum="B2E220C1C4FB3894" modified="2016-10-05" version="1">MCSKGSRSGTPVQSDTEVELSRATSGDKSSQSWRWGELPEPPLRGASAASPESSASPASPASPASHAEPLSSDEERPGRRGVLSGMFRFMSTKDANEATTEGVYLDDLDRGQVDPDLYFPKHHTERYRSVSGAVPQTGGPTEEEYESGNGPSLPQSRTSLEPPAIDSDDDDKILSKGQVSVYLREGAVSRSLTFEEFCARGDSLLAEGRLEVRVGYGHRKLRQDKNRTRPLRYQKNLRILEELDKVGGGVGGAGEVEGGARAGGESAEAGAKPRSYSWWSWRRSNAEAKRTEPSPAKEEIVKDLTVSQQAPDTAKEMKVTINEDQVDSPGEEQDRDTEETNINDIIEPIELTPTEDVAEVLPVTKQTHIKDDQREQSSSDSEQESHQKPSRRHSTFRKTLRLSSDQIKKLNLREGMNEMVFSVTTAYQGTTRCKCNVFRWRHDDKIVISDIDGTITKSDVLGHIFPLVGKDWAQSGVAQLFTKIKNNGYQLLYLSARAIGQARVTREYLRSIRQGEVCLPDGPLLLNPTSLLRAFHREVIEKKPEEFKIQCLADIKALFPHNSNPFYAGYGNRVNDVCAYQAVGIPIVRIFTINYKGELKHELTQTFQSTYSHMSVLVDQVFPPAQCEPSGEFSHAVYWRDPLPAVTLPSPPAAHAALAAPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHQ3</accession>
    <name>A0A194RHQ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_08544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHQ3"/>
    <dbReference type="InParanoid" id="A0A194RHQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="396" mass="46256" checksum="E83862E2435A52AB" modified="2016-10-05" version="1" fragment="single">QSKKYTCDVCCKQFTYYGSLEVHLLTHSGEKTYQCLICNNKFTQNKDLTKHISNDHSDNGTYPCNMCTKIFDKARLLKSHLATHYDIDKFKCNDCGKQFQRKKGLKEHMKTHTKEKNFTCEICHKSFGHSQTLKSHILTHTGEKPFVCDVCGRRFSQRTHLKRHIFIIHTGIKPYSCKDCNKQFSSKSYLAIHARQHTGERPHTCEVCKKDFTAYTTLKVHMRVHTGRKPYTCSFCDRQFAQMASFKLHERTHTGERPYSCKVCKKPFSDNGYLKIHMRVHTGEKPYNCEVCKRSFRETGQLKRHMRVHTGIKPYTCKICNKQIGNLSKHMRVHSDERPFNCSICNKQFTINGNLKLHMRIHTGERPFTCDLCNSQFTQSSGLKRHRCTHVDKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI45</accession>
    <name>A0A194RI45_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox protein homothorax</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_13856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI45"/>
    <dbReference type="STRING" id="76193.A0A194RI45"/>
    <dbReference type="InParanoid" id="A0A194RI45"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIS N-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="26912" checksum="60A12C67FA0B91C9" modified="2016-10-05" version="1">MRLLIHSVGTRRVYFCAGTRSPLYRCCAATDWGERVALALQVTKKWCKQNNSWYSRQHTDAGQWSGVSHYAPPLWQFLIPLRPSDRFNGRKTDLLRRNDPGGPVKWVTNAVIARSIRQEKPYYIADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERESARPPDANGERSAADSGHDGASTPDVVSTPYSKPHLIQRRDPQLAPSSTTSYLVHPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJH0</accession>
    <name>A0A194RJH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-folding cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460313">
        <property type="protein sequence ID" value="KPJ16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJH0"/>
    <dbReference type="FunCoup" id="A0A194RJH0">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJH0"/>
    <dbReference type="InParanoid" id="A0A194RJH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="302" mass="34136" checksum="48C78AE0B33E0305" modified="2016-10-05" version="1">MEVIKVITQDYVNVHITTSDSEDGPPIERRFKKEISVLEFKTKLELVTGGSAATMKLKVFDNKNNFVCDIDNDKALLGSYPIDDGARIHVIDNFTMTKLELVTGGSAATMKLKVFDNKNNFVCDIDNDKALLGSYPIDDGARIHVIDNFTMVKDFAANDSGERFQLSEEDYEKKGDTLRSFLQRNKLGKYNEEEMSKLKEQQQKELEEEANLASKVLVGTRCEVRAPRQPARRATVRYNGPLEGARGFWIGVQYDEPLGKNDGEVNGKRYFTCPPNYGGFVKPVYVTVGDFPEEKYDLEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKG0</accession>
    <name>A0A194RKG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Exonuclease 3'-5' domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_06626</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the EXD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKG0"/>
    <dbReference type="FunCoup" id="A0A194RKG0">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKG0"/>
    <dbReference type="KEGG" id="pmac:106707829"/>
    <dbReference type="InParanoid" id="A0A194RKG0"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000041">
        <property type="entry name" value="Exonuclease 3'-5' domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="15">
        <location>
            <begin position="46"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ17820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="567" mass="65485" checksum="CB50843CA70A2D3D" modified="2016-10-05" version="1">MDTYLKLKTFVTSTALAVGFAGATLLILKYKLRKRNAVDALNYLIIRNVITEESCDEVINELRRRIGLHKAVGFDCEWVTNQGRRQPVALVQLSSYDGYCGLFRLSHLKTIPNSLKELLEDENIFKVGVAPFDDAKYLLSDYSVSLKSTLDLRHIVELAGHTSGGLAFLAQSELNIILDKSWRVRCSNWEVDELTQTQINYAAADAHVSIKIFVYLINKKYGSIWSWLNRSSDNKVWHNINNICWKYADIGFKNKHTSKLGSEIKKDKEGKLTKDSVVSKRYPHATRSKPLYHNCFLVAPDGELLCTCDTKKAEWYVDKGLADVVNDNPLTVRLRFEPSGRSVGDVGRYYQLTKENKCVVCGGDNSYIRKNVVPREYRKYFPEIMKDHSSHDVVLLCTGCHQRSNMRDQAVRERLAEQCGAPLAAHTDNKFKEDADCKKIRSAARALLYQSRKHVLPEERRKELEQIILRNFPQHEQITEELLQKVADMQVVFENIDYESHGHKVVEYFMKHEGLLQLERLWRQHFLTSMRPRHMPQLWSLDHNEQRLKIRLEEGRLSDEDAKLIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKL6</accession>
    <name>A0A194RKL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_07361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKL6"/>
    <dbReference type="InParanoid" id="A0A194RKL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="460" mass="53227" checksum="B581A5E0D4DED8BE" modified="2016-10-05" version="1">MDFDKICRICLESDQKEKYDIYENIYPCKDDGLPNLICKDCTRQLKRAYTFNIQCEESDKKLRSHLKHKQIINGWKEVTDDCNIKVEDLNEKTINGDVVNGLQNTVKTVEDLIKTNDGIKLEPEYKLEDEDSCWDADDDNLLLKEIKSKRESIDNESITDDGNVPESKLPHQCEVCGKFLSTKSNLKAHKICHSDLRPYKCDKCPSAFRGHSTLNQHKKLHTGETPYHCEYCPKKFSRRTGLVNHIRMHTGEKLYSCDICFKSFVQSAQLSIHMKRHKGDKPYLCQDCGKGFPIKADLKVHQRIHNGEKPYSCHMCEKTFATSGNLSIHVRIHNKEVRYKCKECQRGFVTCSAYNVHLKRHKGQRDYHCECGKTFYTSSALKQHKVVHTGEKNYKCKICDRKFSQSSHLGRHFKRDHAKQIPVPSSSYYKLIVMPEANKQTFDVFNQQMAPNGNVKCEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLF6</accession>
    <name>A0A194RLF6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLF6"/>
    <dbReference type="STRING" id="76193.A0A194RLF6"/>
    <dbReference type="InParanoid" id="A0A194RLF6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="109" mass="10757" checksum="C240102EF09767E5" modified="2016-10-05" version="1">MAAASPSVVPAAVVAPAPLVAAPAPFVTASSSQYIARNYNGLVSAPLVAAPAPYVAPAARFVAPAAPLVSAAAPVYARYAAPYVAAPYAAAPYIASPYFAPSAPFVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN91</accession>
    <name>A0A194RN91_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly(RC)-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN91"/>
    <dbReference type="STRING" id="76193.A0A194RN91"/>
    <dbReference type="InParanoid" id="A0A194RN91"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="287" mass="30212" checksum="CDFB2145F5282948" modified="2016-10-05" version="1">MELEKAPTPLHEEDSKITLTIRLIMQGKEVGSIIGKKGEIVKRFREESGAKINISDGSCPERIVTVTGNTSAIFKAFTLICKKFEEWCSQFNEGGGGGSRAPITLRLIVPASQCGSLIGKGGSKIKEIRDVTGANIQVASEMLPNSTERAVTISGTCDAITQCIYHICCVMLESPPKGATIPYRPKPNVAGPVILAQAQAYTIQGNYAVPAQDAVCAPMFPLLEVKPPLVGALPPHHLLPPPLHEHHLIGGLAKSPLAGLAALGLGGLGPANTSGLNPAGNYNNILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNL8</accession>
    <name>A0A194RNL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNL8"/>
    <dbReference type="InParanoid" id="A0A194RNL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="95" mass="10227" checksum="03FE4E9F364A169E" modified="2016-10-05" version="1">MGLCFSFDCGDCDICCNPCCMALSACCLVPCLCPNACGQQQQQPPQTVHVHHPPVIIEQQPPPPGYPYPPPPGGYPGYPPQQPGYPGYPAYPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNQ3</accession>
    <name>A0A194RNQ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_07134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RNQ3"/>
    <dbReference type="InParanoid" id="A0A194RNQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="119" mass="13096" checksum="718451048AB47E5D" modified="2016-10-05" version="1">MSWNYYYPKNFKANGWGWHRGGSAATAVRGFLKRERDGEGSSEPLIGNGGLYPSLPTEDDTMFRTGGRLYPSLPAEEYESGAVEEVVEEACAAVNVNMVVSDSSCWVNKHDSFPVILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP61</accession>
    <name>A0A194RP61_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_06493</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP61"/>
    <dbReference type="STRING" id="76193.A0A194RP61"/>
    <dbReference type="KEGG" id="pmac:106715981"/>
    <dbReference type="InParanoid" id="A0A194RP61"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ19633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="44165" checksum="C19FA4E7F7D1C34A" modified="2016-10-05" version="1">MVGSLMLWKLMHCKRFKKRSSNNNKKEKNLDLSVPSTDPLITVKIEVTEENKICRVCLKNGEVPIYDDNRTEDISEALINFGGIEITPDDEYPKFLCESCYALLRGAILFRKTAQDSDQRLRCPQKESDFESKNTDTSLDYDKKEKDRKKYICKKCDIDFDTFSEYSEHRLSQEHENLKHTCPICKNSYSSFYIKKHMAIHTLEVSHVCDICGKKFTVKGLFTRHRQTHFNNFPFSCSLCPYKGRFKESLKMHMRSHTGEKNYQCTRCPSKFIHKSNLNAHMLIHKDSFDFKCETCGRGFYNKRSLEQHIKVDHNGVKEHTCNICGKAFGYRKQMMKHQLRVHKREKFKSGRMPLYLQIQNKEQVQNETYQTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP83</accession>
    <name>A0A194RP83_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RWD domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP83"/>
    <dbReference type="FunCoup" id="A0A194RP83">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RP83"/>
    <dbReference type="KEGG" id="pmac:106720703"/>
    <dbReference type="InParanoid" id="A0A194RP83"/>
    <dbReference type="OMA" id="CGMTYTL"/>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="185" mass="21351" checksum="3734180C3AEB912C" modified="2016-10-05" version="1">MSEDAEQQAEEIEVLKSIYEGDENFKQVDATTYQYKYIEGDKSFVLEIKWGPTYPTEKPKCNLEIFYNQHLLPSVKEKILAIVDAEAEQWVGCAMTYTLFECLKEKVAEILSEQTEEAVVARVEKIAIDDQTESKKPEKKEQLTKAQKRRAWDRAEIGRAGEKPRGWDWVDIVKHLSQAPHQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPM3</accession>
    <name>A0A194RPM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA pseudouridine synthase A, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_07368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPM3"/>
    <dbReference type="FunCoup" id="A0A194RPM3">
        <property type="interactions" value="2071"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPM3"/>
    <dbReference type="InParanoid" id="A0A194RPM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ17971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="464" mass="54171" checksum="565E0CCE089D4E39" modified="2016-10-05" version="1">MSLRLLTSFVCTVRQTLPRHTIARSGFQIRTVTGMEAATQTDPKNVIEIEAATQTEADKLVRDKKFTRYMQRNKRQWEDEIKDKKEDGETDGKKPCDTPFERIKRKKMAMLLGYCGVDYYGMQRNPGVRTIEEDLLKALFEAKYITEEDFVNQQNAQFQRSSRTDKGVSAARQVVSLKLPLEIDIEEINKRLPENIKVFGVKRVTNKFNSKIKCNARTYSYTLPTYAFEPDLVNDEEKKLYRITEDKLKAVNDVLAFYIGTKSYHNFTEKKHYQDPSASRYMMSFTLDRVFVDSEWEFAELLVKVHYERYDAKFKDSHDSLTWEAEEDSVQTFKREKIYPNIVKGEIEDKSMAFWLEKLNKHNYEPSDDVPSEKEMENEQESDDEDEKENDDFDKVNGEVAKENGDEVDKENGDEVDKENGDELDKENGDELDKENGDSVEMNVDEVKDDNKMNVIDKKKLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPQ7</accession>
    <name>A0A194RPQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G kinase-anchoring protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GKAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPQ7"/>
    <dbReference type="STRING" id="76193.A0A194RPQ7"/>
    <dbReference type="InParanoid" id="A0A194RPQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026109">
        <property type="entry name" value="GKAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899">
        <property type="entry name" value="G KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899:SF0">
        <property type="entry name" value="G KINASE-ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="286" mass="33056" checksum="6C782FD33887AFB5" modified="2016-10-05" version="1">MAALIVQSRFAGLNIEDDDFPTTSCAQKPKKTKVENNKKCEVSKKTKANGNKSQNANKKKKQKANGPTPEQWEQWKEKDEELVDGNFETELQQAILLSKLDYEEKKDVYKQVKKDAEMEKKMESIRVNNKKMKKKNVMSLDQFNEMVNPTEDTKNIKNNETVEEKCINKDTEFFERIKDDTKNELLREKINDRIKNQHSVSDEVLSRVQFADALDKKNQEIAALREELVTLKQELHTVKTRNKKLCNILGQGESHKLTKYPNKKKSIRFDVSSEALVNKEAGCGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ15</accession>
    <name>A0A194RQ15_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ15"/>
    <dbReference type="InParanoid" id="A0A194RQ15"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1152" mass="132997" checksum="33471FA5256314D5" modified="2016-10-05" version="1">MNKNSTNECIPCPPGDPWITCRSKSHHRRIYYYNTVTGEAIWNLTDFENDKCKKTTKESVDARDHSDSYPEPKEPPRDICRKIFISESNEQNKHTDYTSTTFNECTINEPYLEHNLSHNSKVQRCDNINQMNDFMLSVPMAPTSTPNNSLSFINQPQVKIELDHNNVEEFKNNYVHTTSMPLSKRFEITKNIDSPIRFVMPGEEEKSTALEVSEIDTVTQEEIDPLPSKYQQLIVARDLRQIISLKRQSNVTNNIGQQIDCNRTKINSSTIGTLGINNFEEYQTDNINQKLFMNTVVNTTDAENMEDCIYILPDANVFQCHIYFLKFLLKFGKTFHFLVLENVIEAIRKQSRNACFQKKKWAKLALTFISRHIRSGVVSIVQNPIEQNNSGHFFVVECCLKLVEEYDKIILLSNYEHLKVHEYADRLLILTVNELKSIVNTFGNANLIRNNLFPNERCQNESMQHVPNEHIESDYDMIEEKLPKLEPTKVSIGVETCKIIEEKNTVDASVQTDLDSELLTRILNIESVKTILADSVKLKEMLNKENFNSFLKDWDVSLNSPKSVTKNKENNASQRNFKWRRKRPRSLVEQKEGIQHSVTKNLMVQIPKEIVCSVVGKQFRNKCNPSANDVTPTDGSSTSGIVSIAASPNDYWTEYENNRNVLVTSVDKESEIDINNVMFEVTSNAMNENLKSRSDEWVSRFVQIMEEALTQVLQKNPTQSPNVLAPPWTLFEATTCIKMKYRKDRDIVDAGNKLTNTLTKISDKKGTVNIHLAPKQYMEMYSYGVYLIDTLQAAFEGCEDLQTASESLSKLLYDIEHPNLSTSQNDAFIDVQDEIIVNTSTTNKESKEKTLPTNEEDSLVHQKQQVDLSPVPSPSKRKLRLKFKNKVERVNDVKSIEKAESKTSVLSTLDSKNYNDVCEKESLKSFINEEPRTPLYDPPTLDEVQTLKNITTESQMNVAMTTNSNNDSKQPKIIINFTQCAEYEEKLKIKTLELNDTDEESYLDNDNDYTSDDEYNHYESNKEWPNDNKHFKFENIFNIMFLDIRQTFIIVFAFCMTCQKAINISDPDRKLLEAKEVYSKITNICNILSRIIKRDDKLFMSQIAEVLKAEDVMEDFKFDESDLRKYKEISTKYLEQANSLRECLETIIRHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQQ6</accession>
    <name>A0A194RQQ6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQQ6"/>
    <dbReference type="InParanoid" id="A0A194RQQ6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="625" mass="68338" checksum="84EE6152DF689478" modified="2016-10-05" version="1">MEESWSSGGAPLLRTRSLPLVLEAASAPARQPKLDPRQLLTLTRHYYPEGGWGWGVAAAGTLVQILAHGLHQAAAVLTFEVVRRFGPEVRIQAGCLGALSVGVALALSPVSVALCVRKSTRVTAVVGGLVAALGCLFTSFATQFHQLFFSYGTVVGVGVGLTRDCSTLMVAQYFKRRRELVEIFIVSGSGLGIAVMSTFIKGAIRAIGWRLGLQAVTGVVFVTFILGTFYRSASLYHPQRRAILHLKNQNKIKRKMKDKNKSDDRQPFFDFSTLRSKTVRILLMSTGISAFGINTPIFYLAYHAEEEGLGDTAGLLQAYLGLAWAVGCAAFGLLVRQKSAECRIARQYLTQAAVFVCGLATMALTAVEGSYSGYVMFAWVYGIFCGGYHYSLKMYTYERVRSRNFARTWGFVQCSQAVPIAIGVPLSGYINVGCGSKAGYYFSSTCSLLGSLSLFCIDLHRRSVAHKHTKENGGTANCESACGQSRRSRSRDREPRTATGAATALGDPSSLSKIIRQQSLLICIPQYYIPEHLLEDLDCGGDCITSCNKVENYLVLSEYENNLIAELPNLNERRGRRWSIVVGNSSPPAAPDDQTTPEHRNSIKWKKKCHNSNNRLITVINEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRM5</accession>
    <name>A0A194RRM5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRM5"/>
    <dbReference type="InParanoid" id="A0A194RRM5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6655" checksum="B3E0DD8B49EA474F" modified="2016-10-05" version="1">MSGRPRTTSFAEGGKSVRKTFENQPPKPPLGGVKICSKYHLTILLSAIVISYTVTYSILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSC5</accession>
    <name>A0A194RSC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSC5"/>
    <dbReference type="InParanoid" id="A0A194RSC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11444" checksum="94E41C5B9BF59108" modified="2016-10-05" version="1">MDRPCVTNAEDRTRRAAPHRRQYQLIFHANASHYRGSERSVVTSSPIAQVCCRLDALKEREGFGIRDGYNAGFLRLIPPLPRSTSPCLRLGHKTCAFSHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBC9</accession>
    <name>A0A0N0PBC9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460969">
        <property type="protein sequence ID" value="KPJ10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBC9"/>
    <dbReference type="InParanoid" id="A0A0N0PBC9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="18960" checksum="CB96912F3770AA61" modified="2015-12-09" version="1">MVFLITPYSVTAPITFGSVGDPSSVYSQTGHKINTQKMDPPTGLTLVGAVTGWPKQLNKMDNISKYMTPMDELDIALLSLDNVWMKTAQPIRGRNDFNFDDNYSSEESDVSDTNDYSVTALIDITDALTIFKKGEDSQKEDISYSSVPLTVNCNSPYRNWEEERTKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PD88</accession>
    <name>A0A0N0PD88_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460326">
        <property type="protein sequence ID" value="KPJ15711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PD88"/>
    <dbReference type="InParanoid" id="A0A0N0PD88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="217" mass="23926" checksum="BE9A21235B8F8E6C" modified="2015-12-09" version="1">MDRGRACSVEQTRARGRPRHVHTNRGIGSRGCRVSLCAKKIIAKKQSQAGYEVSPQLYSTQVSPKFYNSRTVSQGSVYRLPSTSSASYYPSSQTYTQYTSAPRVQYRVQAAPAYSQVSVPALYNAEHSEHASSSSHYRLQAALPAALTLAQPSAQYAQPSAQYVQSATQYVQPSSAQYVQSSSTQHVQPSVQYVQSNAQYAQPSWQQGSWTANNPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDK5</accession>
    <name>A0A0N0PDK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RalA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_05347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDK5"/>
    <dbReference type="FunCoup" id="A0A0N0PDK5">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDK5"/>
    <dbReference type="InParanoid" id="A0A0N0PDK5"/>
    <dbReference type="OrthoDB" id="10033734at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="228"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="691" mass="79784" checksum="BF502B420364A41C" modified="2015-12-09" version="1">MDFESPDVEKDFPGLYASETGRKSNESDFSDGADHEKPSKKDLLGRRKDKKESKKDRGYAALEGESSPEEDTDTKSPSKSKKTKSFKFPSKNKEKREKSRDKEKTVEETIKHKEFNEKEKKKEKEREKEREKEKKEKEKREKLKEKDKEKEEKAKFKLESKEKLKDDKKDKVKDKEKEKVKEKEKEKVKEKDKDKKDKKLTKVPSTVTSGVPFEEIFTLGVALPIFGVPLQQSVERSRCHDDTLLPLVVRDSIDFLQAHGLKSNQIYRADPDKIKLQQLRRLFTDRGPTFPYHWDVPVACAMLKTFISELPDSILTQELHGQFEQATAIAEPQREATMVALVAKLPACNHNLLAWLMRHFATVVANEQVNQANIQTITNFMGPALNMSQNLLTYLVAKADKLFPDVRLEKYVPPLLSMPADFPECGEVMRCELRKQESLLSQIHAEMHAGFITPARDQRLWEAQRIVTQLKRKLRSVQKSVEPNALPQQPSIEDKPPEEEPIKETQTNETVTQADVETIKTPSTDAFQDIKESPNVPDPTFPVEFEDNFNFQTTEIKETPEEEPQPPAEPVKEKPKLTEKELKVLRLELENAEYLQLKSLLQAKINSEQFEIVKLRSHVAIKNKQEGNVQTNKEPKESYTAEEQELRQKLIKENAMLEQKRLSLVNQIFQERVACVQLKIELAMNEILSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDS3</accession>
    <name>A0A0N0PDS3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork head domain-containing protein FD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_05518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in development during embryogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDS3"/>
    <dbReference type="FunCoup" id="A0A0N0PDS3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N0PDS3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="67"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="67"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="299" mass="33688" checksum="6B2F879967A7B07F" modified="2015-12-09" version="1">MRRAAASLAYYLRTTSARGAGAPPLGAGSPGSPPAAPRLPCRAPRTVTPLASTTMPRPSRDSYSEHKPPYSYISLTAMAIWSSPERMLPLSEIYRFITDRFPYYRRNTQRWQNSLRHNLSFNDCFVKVPRRPDRPGKGAYWTLHPQAFDMFENGSLLRRRKRFKLHKGEKDNLNAELAALATFNRLFLSGQSATRVPPLEPFQVTQPDSCTTKVKPKKSFTIDSLLSSDSELESIEDSVTLINEANTLVPYHSDVLAMAAAIWPAPICFQIPLFNPLQLTLPFNPSIHNFGAYHLTEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDW1</accession>
    <name>A0A0N0PDW1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caprin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caprin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460202">
        <property type="protein sequence ID" value="KPJ17185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDW1"/>
    <dbReference type="FunCoup" id="A0A0N0PDW1">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDW1"/>
    <dbReference type="KEGG" id="pmac:106708552"/>
    <dbReference type="InParanoid" id="A0A0N0PDW1"/>
    <dbReference type="OrthoDB" id="10062814at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028816">
        <property type="entry name" value="Caprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041637">
        <property type="entry name" value="Caprin-1_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922:SF19">
        <property type="entry name" value="CAPRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922">
        <property type="entry name" value="GPI-ANCHORED PROTEIN P137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18293">
        <property type="entry name" value="Caprin-1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caprin-1 dimerization" evidence="3">
        <location>
            <begin position="101"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ17185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="605" mass="67847" checksum="C0B65861AE5CD2D0" modified="2015-12-09" version="1">MPSAANAKSEKPASSEATDNSPVRQIITVIEHKIRNLEKRKSKLTSYRDLQKAGKELNTDQKVAVAKYDEVVQTLDFARDLSKQITAIVSSAEREAKKQAKKDAWVRYAAETNKIREVLLILDCLMQMGNSDAREDFLNGTNGAAKLTQEDLKILDDLYPEVTPKHELNEEGQSGFHMQTVKAAEHLYAIIDGKPKEILGTTYAHIKEIVTTVHECGYFDKSVDNAGVENDEVHVIVDEEQQQVMPLEVEETNALPYPPPTMLPAAPAPSVVPAPAYPLRPLPPITLQEVEHAYFSQQYPQQRPISEVIGSQNFFFLQESEIDSPIGTPHPPQIMNQPSPPAPIPTQTFTNQHFVQLPGGRVPEQTPMPMPPQPHFATHHEHAGYPGVPLPGPLPPQQPLTHPQPVPQPQMPPIPQPIPQAVPIEQQPPAQVEERKAPTPSEDKNEEEWKESRSPENEEGYERKTQGQGDGQNRYRRYGRTVIRGSSNGYRGRGSYQNRQNDGYHPRGEYQNRGNKDGYQNRQYDGYQNRHKDGYQNRGGSEYYGNGDTGDSHHHENGGRDRYNDNNQYQGGFKGRGRGGPRGGARGAPRAPRPQQYNRKPENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE97</accession>
    <name>A0A0N0PE97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459933">
        <property type="protein sequence ID" value="KPJ19272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE97"/>
    <dbReference type="InParanoid" id="A0A0N0PE97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="89" mass="9595" checksum="86BFE0EE9CF500C9" modified="2015-12-09" version="1">MRTRSPPPLSYALASSPLSCIQYVSTPLHISISQEGCPSPHRATSLRSNYSKVQMLTHHGSKAGLVAAGGAERNNKNRDNLRRSATYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEL0</accession>
    <name>A0A0N0PEL0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459753">
        <property type="protein sequence ID" value="KPJ20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEL0"/>
    <dbReference type="InParanoid" id="A0A0N0PEL0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="69" mass="7960" checksum="5103B2E47A77ECCB" modified="2015-12-09" version="1">MSARLRRCGGHRLVKRKSKSSIQSTISEDQPPAYKWDADKQTYDQICLSTELKMADGYTNHLQIEFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PER0</accession>
    <name>A0A0N0PER0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459713">
        <property type="protein sequence ID" value="KPJ20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PER0"/>
    <dbReference type="InParanoid" id="A0A0N0PER0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="84" mass="9943" checksum="FD30515E481EF92B" modified="2015-12-09" version="1">MLMKHIHIEHPDDGTAKCPHCSKQLHSPQGLKQHIHKCKVNFMKKDHPVDDKFTDILLQPKKKQNIKQIRQNIQCVLNMLRQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFC2</accession>
    <name>A0A0N0PFC2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01019908">
        <property type="protein sequence ID" value="KPJ21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFC2"/>
    <dbReference type="STRING" id="76193.A0A0N0PFC2"/>
    <dbReference type="InParanoid" id="A0A0N0PFC2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="14637" checksum="87E415BAFD6B2636" modified="2015-12-09" version="1" fragment="single">ELRKFGQEFKLVSSGAPPHQQAQQPHPQHPPHAPHPQHMPHPVHQPHQPHQPHQPPVNTQPPQLPPPAPSPPEVSANAGAPSDPLPKRERPPKQHTPPAAHKVTIYINLYRTIRFPRLNILIQHNILATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFP7</accession>
    <name>A0A0N0PFP7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01024180">
        <property type="protein sequence ID" value="KPJ21122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFP7"/>
    <dbReference type="InParanoid" id="A0A0N0PFP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="3">
        <location>
            <begin position="204"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="303" mass="35223" checksum="DFE5BFCF893AB6A7" modified="2015-12-09" version="1">MPSEYRTYCDQKYGKWRTMFLPADYSQCRCCDECIFYRELDQSCMEDEYNFDTEEFLPVTTVDFRAGCNPYWGHPEQEVKALRCDPVLRRCVPVTIPVLPKDTLSVRRSFRYELPTVEECPVSCRGYDCQSLVHEDQCPQGAFLPDKDYCNCCGRCSTFFQEEFLEPGCDDGLVCRQGICQDTHTLMSRSMQRLKREQLPFGALEPCKQEMKYFKKKYGVNGHLHHEAPQCTPLWLYAPVQCRRFVCYCALEDGSRIEGIKVPRVEVSNMNCGKILFFFYASNGQPFETGFSLDLYSNFSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5H6</accession>
    <name>A0A0N1I5H6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor BCFI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461033">
        <property type="protein sequence ID" value="KPJ09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5H6"/>
    <dbReference type="STRING" id="76193.A0A0N1I5H6"/>
    <dbReference type="InParanoid" id="A0A0N1I5H6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="274" mass="28674" checksum="7032922B9B7C073B" modified="2015-12-09" version="1">MEMGAPLALNGKSQLERTSTSVDYSGVAPLALPPAPAAPLAASTPPDYKQKKGSWASTLGLVTIAAAAVTKTPGVRVQMGSKRPGLTCSNCGTSTTSLWRRNVHGETVCNACGLYYKLHGINRPLAMKKDSIQTRKRKPKNSMKGERNLSKSNSHGTHGAHSTHGAHATHGTHGAHGAHTPHAASNAVPSTVKLENMLENGPGVISVGNAESRAALALGYYVQHAIKLDEPPPAHAHSAHAAHVAHAAHAAHMYEEEYRRAESGERSAAVSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I6B5</accession>
    <name>A0A0N1I6B5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxysterol-binding protein-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I6B5"/>
    <dbReference type="STRING" id="76193.A0A0N1I6B5"/>
    <dbReference type="InParanoid" id="A0A0N1I6B5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="295"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="664" mass="72169" checksum="CAFF807A777D50E1" modified="2015-12-09" version="1">MSSKDDTGREAEESLLYSARHGELSVVRALLEAKREGKLTLDINCKGKSRINYGWTPLHLATYFAHKEVVEVLLDSGVNVDEVNDNGDTALHKASFTGNEELVILLLNYKADVNIMNGEGQTACDVSKTHDVQRLLEAAQKSERVDKERQLLTAAKDGRVEDVQALLSGVSPPNINCVDSQGNSGLHCAAYRGQARVAVLLLQNGIDTTLRNNTGKSRINYGWTPLHLATYFAHKEVVEVLLDSGVNVDEVNDNGDTALHKASFTGNELAIDLAKDDDMREVLSVRPVQKLQRTAARFEGPLLKKSRFLGWRPVWAVLQRGVLMYYGSRAEAARCGAGRGGVGGGAKKYLDGARLTAPPAQPALLLLHYSDGDSHRLAVDAAEPDTLACRQSWITALNEHIAYSGHYLWAGAGPETAKEATEDDDCKPLGSMQDALTTANNRLAVLETQLRECGAIVAALDNTAALGNSLHHSAYMRFQHACGTGAEALSALRHCAALVAQARDRDQARLARELERNRVLEEALAALARTHHALEMSVADEITKSKRKKKLSQTESKENFFDVYDESGDDDDTLVTAGLSSPLGALSPWGSSPDLTRHTPIGSVYSDEDDKTATNEGKLERAVSGSSWSFRSECSRGTLVSQDGHVYRNARPYRSPATPSSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I891</accession>
    <name>A0A0N1I891_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460820">
        <property type="protein sequence ID" value="KPJ12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I891"/>
    <dbReference type="STRING" id="76193.A0A0N1I891"/>
    <dbReference type="InParanoid" id="A0A0N1I891"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="432" mass="50915" checksum="4005CF4EE61647F6" modified="2015-12-09" version="1">MEPVNKLEEWSHEEVLSVLQRWEMEELCEFVKEKQLDGKNLMNVTEGIIKLWKPKADAKKMLLFLKDLKENPDKYVILPSSKKEIVKVSKETNICPESQYQTVTVRKTREEVNVNTVEEILKKIVPAKSFLYRNQQKRTEKAVTSYLPMDAGTTRKKSFFRLSSYEYPFFDIRLRFSKIENNTDRGYYSVKSNRYCIQKSCKKQEVKTKYKSLPSPEPISNNIIEDHFYEDLNYNEMNKINDTKETSSSGQGVQVKPCMVKIQELFQSFKFPFFRKSEEVLPTRKISKEEKDGNIYENNDSVLNMYDSIHVMHDDAKAESKEEKHTLPVEEYLEPVQLHQEYCDVRRRHEDSLLGYIMNYFENRFGVRRGPEGRECRGDWACKCGGDVTHHYLLLPRCERRPFRSKARLRTIKLAKSNKMKLVEAREGGLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8J0</accession>
    <name>A0A0N1I8J0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein RAD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460391">
        <property type="protein sequence ID" value="KPJ15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8J0"/>
    <dbReference type="FunCoup" id="A0A0N1I8J0">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I8J0"/>
    <dbReference type="InParanoid" id="A0A0N1I8J0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF1">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 3, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="255" mass="28574" checksum="D9AF190696964E0C" modified="2015-12-09" version="1">MVGAPGVGKTALISQFQTSECINAYDRQRDVDSSEQKVSILLNGEESELYFVNCTSAKVNLMSNRLETKIAYVDSSEQKVSILLNGEESELYFVNCTSAKEEIDRLEPPDAFVVIYSVVDKASFQKAEQELARMLDCDMLRSRPALLVANKIDLARSRAVSTQDGKCLACTYKAKFIEVSVGINHNVDELLVGILNQIRLKKQQYSAEGGRESSPAHWYKSRGVVRASMKARQMLTWIFGKEDAKFKNCENLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I8X7</accession>
    <name>A0A0N1I8X7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTBD17 TRAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460271">
        <property type="protein sequence ID" value="KPJ16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I8X7"/>
    <dbReference type="STRING" id="76193.A0A0N1I8X7"/>
    <dbReference type="InParanoid" id="A0A0N1I8X7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056184">
        <property type="entry name" value="TRAF_BTBD17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23651">
        <property type="entry name" value="TRAF_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTBD17 TRAF" evidence="1">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="201" mass="22877" checksum="E62C4118002B7F5D" modified="2015-12-09" version="1">MYRDGLLVGQYERVWEVQQTAGGRALFTPRLYTEDTWGSVLAVDNFHSLPCYHMRTFIFSTRPALADIAHTDRMMEWTVDLYPKGVWFRKSMLIAWSGTYDVPEAVLRTVRIAITCLSVTAPDPYRPEPDVRVKIGILVWGRQNGVAHISDVAVRVHRFSAQNRVLNIDDALDFDELNTPLYTPAQPASPGNKQGSVYLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ID86</accession>
    <name>A0A0N1ID86_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nose resistant to fluoxetine protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461184">
        <property type="protein sequence ID" value="KPJ07535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ID86"/>
    <dbReference type="FunCoup" id="A0A0N1ID86">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1ID86"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="192"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ07535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="612" mass="70609" checksum="49767C66201A0E0B" modified="2015-12-09" version="1">MPRLFDLDRYDSCLGSDHGLYCVLRVDLFADEHNELMNQIKEYSAYTAKHYNYTNIDRGVCITQTCKEFIKGRDLEKDDERYEVIEECLNTTIFKQYGLQANVTQIYNCDKHNEKAQIDATDWIFAAMIAALVFVVLSATLYDAMHTRLSESKNNMRSEGNYLLMNFSLRKNWNDLVNEESADPRRNRLKVLRGVRAITNCLMILAHVFFIYTTGFIDSPHAVEKTYESFQYHLVYNGLLIVQIFFLMSAFLQSYLMHLRSEVSPIQWSELPMIMFARWWRLSPTYAVLLAFSGTWMRHLGTGPLWKMYVGDSMAAQCRRYWPQHLFYINNYIAGDTACQVQTWHIAVDMQLFVLTMLVYMCTRGRGRSWQLALGLLLLAGLLGPPLHVWLQDLQALTMVTPEFFRRLADTRTFRLLHILCHNNLICYVVGLATGSLVYRLQKDNRWGMLSWCLVPGIACLFLTGRVFFAEGAELRGGVSGGVVWRALYAATLRLAMAAIVSMLVVTLTMRFCENFSKLFEWRGWLLPSRLSYSMYLLHMNLVHAALGLRTQLATISPFYLLVTYFGILMMSFLIALPFYLVVEGPLAGLLLSLLGNRQKTHPQHNNEKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE31</accession>
    <name>A0A0N1IE31_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoribonuclease Dcr-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_01065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460997">
        <property type="protein sequence ID" value="KPJ10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE31"/>
    <dbReference type="STRING" id="76193.A0A0N1IE31"/>
    <dbReference type="InParanoid" id="A0A0N1IE31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="140" mass="15832" checksum="C0494555B795199E" modified="2015-12-09" version="1">MPTRVLARRMVALQACRILHKSGELDNQLMPIGKENFKAVELEGTGNGNGNGIEPIDPNDSARPGTTKRRQYYYKRTACAFTDCQPVVDATDEEIESGEYDASKRHFKPGWQASKRSHEFEIARRTLPTDILNFRCVAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IE45</accession>
    <name>A0A0N1IE45_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_00132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01024000">
        <property type="protein sequence ID" value="KPJ21119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IE45"/>
    <dbReference type="STRING" id="76193.A0A0N1IE45"/>
    <dbReference type="InParanoid" id="A0A0N1IE45"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ21119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="83" mass="8950" checksum="00561A14CD202CF2" modified="2015-12-09" version="1">MIPPDEVMMRSKDEILIVFQGMSFIAAVLILNMEAPQAFVCFANLLDGPVLRAAFTRDGAAMQDSNPGPADCKSSASSQHLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFL4</accession>
    <name>A0A0N1IFL4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LAG1 longevity assurance-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_05398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IFL4"/>
    <dbReference type="FunCoup" id="A0A0N1IFL4">
        <property type="interactions" value="2301"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IFL4"/>
    <dbReference type="InParanoid" id="A0A0N1IFL4"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="212"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="455" mass="53629" checksum="AFB478812E899559" modified="2015-12-09" version="1">MLRPLLDFFWSPNVWLPPNTTWEDIAPGPHKAVRYTDYRHVFFPIPLAFVFITLRFILQRTLYAPFGKHLGIKDTRNRKAPNNPKLEAAYRASPKLKQPKYVKKYNHLFPFFYKRNGILHKFRQWELNVGLVQNCNVTIKSRTLYAPFGKHLGIKDTRNRKAPNNPKLEAAYRASPKLKQPCGLAKQLDMTERQVERWWRLRRSQDKPSTLIKFCENLWKFTFHSSNFVFGLCILWDKAWLWDVDHAYLGYPHQGVTDDVWWYYMISAAFYLSLTISQFWDVRRKDFWQMFVHHVATVTLISFSWVCNLHRIGTLVLLLHDAGDIFVEAVKASKYANYQKTCDTLFLGLIIVWIGTRIIIFPYHLLWSTWIRAPMLLPMFPAYYIFNSLLLLLLMLHIVWTYLILQMAYRTIQAGKMEGDIRSSSDVSDSPATNNHNDNNINKKLVQPLTTSPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGD8</accession>
    <name>A0A0N1IGD8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein PCOTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGD8"/>
    <dbReference type="STRING" id="76193.A0A0N1IGD8"/>
    <dbReference type="InParanoid" id="A0A0N1IGD8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="375" mass="40098" checksum="839678D50DA4944E" modified="2015-12-09" version="1">MKRRMSRQAWQIALKQPRLMSSELKSLVASSKMKPARKCDVPCRPLTCSPVRGNPTYKLYVLPKIGIPKSFHNRSKLILRTRSSLSPPCRRMSAMVKKEVHARNQILKLKVNSTIIKNTRSASCCPPCCSPCTLPPPCNQPPKCLQSMTGYYHYPYGFWFCGPYHVRTGPVPIDGPVKPGGVCGPVAGPCNPCAPFNPCGPCAPCGPCGPCAPCGPCSPCGPCGPCAPCGPCAPCGPCAPCVPCGPCGVCAPCVLCAMCHAQPARAPAPAAAPQWNTNYTHGSFCNQCGCPKPPAAIPKRATISNENAVPKNLEAKSSNTLPSKVAAQSLSTIIDQASTRNTIEIDPTFIKTFPFNKPTFKRTESFKQPTTKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGH5</accession>
    <name>A0A0N1IGH5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">RR48_04473</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Ya'a_city_454_Pm</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IGH5">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGH5"/>
    <dbReference type="InParanoid" id="A0A0N1IGH5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:epithelial fluid transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:neuron remodeling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="VDCC_a1su_IQ"/>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
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        <property type="entry name" value="LVDCCALPHA1"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
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    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="36"/>
            <end position="56"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="68"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="129"/>
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            <begin position="340"/>
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            <begin position="455"/>
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            <begin position="541"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="726"/>
            <end position="752"/>
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            <begin position="772"/>
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        <location>
            <begin position="836"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1428"/>
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        <location>
            <begin position="1570"/>
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        </location>
    </feature>
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            <begin position="583"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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        <location>
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        <ligand>
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        <location>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    <evidence type="ECO:0000256" key="5">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
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            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KPJ14613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1753" mass="200185" checksum="5F4A9F724D114C85" modified="2015-12-09" version="1">MILTTIFANCIALAVYTPYPSGDSNYTNSVLEKIEYIFLVIFTGECVMKIIAYGFVMHPGSYLRNGWNLLDFTIVVIGMVSTVLSSIFKDAFDVKALRAFRVLRPLRLVSGVPSLQIVLNSILKAMVPLLHIALLVIFVIIIYAIIGLELFSGKMHKSCYNKLTDYFDNFGLSMLTVFQCITLEGWTDVMYNIQDAMGNSWEWIYFISMVILGAFFVMNLILGVLSGEFSKEREKAKNRGDFQKLREKQQLEEDLKGYLDWITQAEYLEPLADQHDTADQKRDYGMGQTTSENDSTDNLGIEVLTEQKKKMSIGECWKKDFDKVNRRMKRACRRAVKSQTFYWLIIVLVFLNTVVLASEHYHQPSWLDLFQEYGNAFFVALFTLEMLVKMYSLGLQGYFVSLFNRFDCFVVVGSISEMVLTKTEVMPPLGISVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIMIFALLGMQVFGGKFNYDPVEEKDRHNFDCFWQALLTVFQILTGEDWNAVMYEGIKAYGGVGSVGILACIYFIILFICDILLNVFLAIAVDNLADAESLTNIEKEEGQAAEEKEGGSIIAEGGHADTDDEYIHDEDAYTTDNSEREYEETGSEGEQQEEIEGEEDIGPEEEIGEERLEDEQERDDLDMMESHQRNHIEFDDEPRLKRKPTTSSARPRRLSEVDIRDSKKPIPDASSFFIFSKTNRFRVLCYKLSASSTFGNIILVCILFSSAMLAAEDPLDAAQRGFRNWLLSQFDMFFTGIFTLELFLKLVTYGLVLHPGAFLRSAFNVLDMLVVCVSLISMSFKFRVLCYKLSASSTFGNIILVCILFSSAMLAAEDPLDAAQRGFRNWLLSQFDMFFTGIFTLELFLKLVTYGLVLHPGAFLRSAFNVLDMLVVCVSLISMSFKSGSISVVKILRVFRVLRPLRAINRAKGLKHVVQCVIVAIKTIGNILLVTSLLQFMFAVMGVQMFKYVVKCVIVAIKTIGNIMLVTYLLQFMFAVVGVQLFKGKFFRCNDISKMTKEECQGTYLVFENRNYVVRDREWRRNDFHFDNVMKGMLTLFTVSTFEGWPGLLYVSIDSNAEDRGPITNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPIRRYIPKHRIQYKVWWFVTSQPFEYAIFVLIMINTITLAMKYHNQSPEYSKTLDLLNMLFTAVFALEFIFKLAAFRFKNYFGDAWNTFDFIIVLGSIIDIVVSQVNELKNQGSGLPRAHVVKESSIPSINFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLILMLFFIYAVVGMQVFGKIAIDDDTPITRNNHFQTFPQAILVLFRSATGEAWQDIMMGVSPEPEVKCDKNYEDEGEEGGGTCGSVLAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRYNNVFSTDILFSETHSFGKLCPHRVACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLKIKTDGNIDDCNTELRAVIKKIWKRTSPKLLDQVVPPPGDPNEITVGKFYATFLIQDYFRRFKKRKEQEMRQSDEQNHQMTLQAGLRTLHEAGPELKRAISGNLDDITADTDVPMHRRNHSLFGGVWSSIRRHGPNKHFNRHRKPGEGPTEAVGNHLSSMMQKEYGVGPLPLAPNLANGQPKEQIPLRPLILNGESEKIYQVLERTTNDLKNAIYKGSETCDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGJ9</accession>
    <name>A0A0N1IGJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">5-hydroxytryptamine receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_05486</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGJ9"/>
    <dbReference type="KEGG" id="pmac:106720492"/>
    <dbReference type="InParanoid" id="A0A0N1IGJ9"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="102"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ19176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="570" mass="64513" checksum="D3D384F0D0B68D28" modified="2015-12-09" version="1">MAAQGYKFNRSQPSFVTLPSCLLIFIYLALQLDLAFASYDLDDIYLSGLNVTNLNSTFNWTLVENTTTIVRNSHIKHSKYSTSVTILLAIVFMIVIFGTIVGNILVCVAVCLVRKLRRPSNYLIVSLAVSDLCVATMVMPVAMIYDLLGTWPFGPVVCDFWVSSDVLSCAASILNLCMISVDRYYAITKPLEYGVKRTPRRMLFCVFIVWMSAAFISLPPVLILGNEKTETSCSVSQNQGYQIYATFGSFYLPLTVMVVVYYKIFSAARKIVKDEKRAQSHLETHCYLEINVKNSGATEAKLLDTQEPQPPTRGSTASTNTMCSSEKTESSIGRCFTGQRKSNESQCPMLQHTRTPTRPIHTINRPPANVENVRDPKRQNKDGRRRPSSESTSKLSTSRIRSSLSNFANKSHLAKDLLHQSHSPHQKKLRFQLAKERKASTTLGIIMSAFIICWLPFFVLALIRPFVNEDTIPDAVSALFLWLGYVNSLLNPIIYATLNRDFRKPFQEILFFRCSNLNHMMREEFYHSQYGDPDQHYCVNNPSKIQNYDEGVEIVSAVDREEIRASESFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGT0</accession>
    <name>A0A0N1IGT0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGT0"/>
    <dbReference type="FunCoup" id="A0A0N1IGT0">
        <property type="interactions" value="1305"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IGT0"/>
    <dbReference type="KEGG" id="pmac:106713352"/>
    <dbReference type="InParanoid" id="A0A0N1IGT0"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="28356" checksum="E49A88B48EAE3910" modified="2015-12-09" version="1">MTELLLDPNIRVWVFLPIVIITFLVGIVRHYVSIILSSQKKIELLQVQDSQVMIRARLLRENGKYLPRQSFAMRRHWFNNEDTGYFKVQKRAAASQNPMTDPGMMTDMLKGNVTNVLPMIVIGGWINWMFSGFLTTKVPFPLTLRFKPMLQRGVELAYLDASWVSSASWYFLNVFGLRTIYTLVLGENNAADQSKVMQEQMSGAAMAMPPDPKAAFKAEWEALEITEHRWSLANVESDLLATDSNNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IHQ5</accession>
    <name>A0A0N1IHQ5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_00524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LADJ01009258">
        <property type="protein sequence ID" value="KPJ20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IHQ5"/>
    <dbReference type="STRING" id="76193.A0A0N1IHQ5"/>
    <dbReference type="InParanoid" id="A0A0N1IHQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A0N1IIB6_PAPMA</name>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
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            <taxon>Papilio</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KPJ19328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="90" mass="10159" checksum="A8A8AB2B85FD69A1" modified="2015-12-09" version="1">MAHATVPKYRELKQPNRDGFKLSSAWNPVIQYYNKTGQQPTSSTRTNVDTVSVVCRQTKITSSADLMCSENADSGSGRRIRKKVDRYGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INV1</accession>
    <name>A0A0N1INV1_PAPMA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Papilio machaon</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
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                <person name="Zhu Y."/>
                <person name="Feng Y."/>
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                <person name="Zhu D."/>
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                <person name="Wang J."/>
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            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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            <strain evidence="1">Ya'a_city_454_Pm</strain>
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        </source>
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            <dbReference type="EMBL" id="KPJ10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8931" checksum="4360D8163720D5D2" modified="2015-12-09" version="1">MFFHESSDSDSDYEEDMQLLALATLLIKQKKRRRYWIHPVNTKRETKGEFHCLVKELESDAEKFHQYFRMSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB5</accession>
    <name>A0A0N1IPB5_PAPMA</name>
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        <submittedName>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
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            <dbReference type="DOI" id="10.1038/ncomms9212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="76193.A0A0N1IPB5"/>
    <dbReference type="InParanoid" id="A0A0N1IPB5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15294">
        <property type="entry name" value="7tmC_GABA-B-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="120"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="920"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50259"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14609.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113861" checksum="C683FBEB9BACE82C" modified="2015-12-09" version="1">MALAIQTVAQRVKLKHKEKTVQDFRYRDKEWEQLFLDALSNVTFEGVTGPVRFYDNERKASILLKQFQGDQVGEIKVGEYCAERDHLDLTSWEPFKWVGKNPPKDRTLRLIEHTQVNITIYTVLVSCSVLGIILATGFLAMNIHYRNQRYIKMSSPHLNNVIIIGCIFTYMSVIFLGLDSSLGSLGAFPFICSARAGLLMTGFSFAFGAMFSKTWRVHSIFTDVKLNKKVIRDYQLFMVVGVLLAIDIAIMSTWQIFYPFYRATKQMEPYPHPTSEDIVIVQENEYCQSEKMTIFVGIIYVYKGLLLVFGAFLAWETRHVSIPALNDSKHIGLSVYNVLIMCIMGAPIAHVLADHKDALFVLISIFIIFCTTATLCLVFVPKLLELRRNGQPGAAGSRIRATLRPTTTHECRDPGPELERRLKELRQYNNRYRRTLQAKENELQMLLSKLGSDASSESSTRESRSPAQRVRLPTTRENISHPETSDITSVCSLSASAGAESEYINLQSQTNIEKPKPSAPPEPVKEVTIKEPKKEQTKNVSFKNHLDYTSPPSSKAVPEKDQLAKLPYGWSTEEPPEPPKPITKPSEPVKAEAKTVSVLKTSDTSTAKSVPAKVQEPLYTKAAAPKVLKTPEAQKKVTKPPDTATKSTPVREVKSRHRRMSSASPAMLADLMHISVDRDDVESSMDRKVIGQRRDSEKRKKESFIVVQSDLWDTNTFQYTSQKSPPAHAHSPMQRSVSEKSRQQSSPHHHREPDTRSMERRASNTSINHNGTTRGGTPEGYRDSDTLKMSDRLTKRRGSEFPQPVSTPPHQLQTKRRQSAAYMRSYQEEKSEKPEATPRRHDDIPRKHTPEPKIELESWKPEPDTIRVAKGPESPAKRLKQEAEPLKRAKGVGESPKLTQATHQTRPDHHKSSPNVASRHKMESNGKKEERKSATYSRSDSKRQDSVEQRKMYTASSESELFECAILPIFQKLLTERHKSQPHGLNLSYGVSCPNISIKCDIVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPE8</accession>
    <name>A0A0N1IPE8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460401">
        <property type="protein sequence ID" value="KPJ14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPE8"/>
    <dbReference type="STRING" id="76193.A0A0N1IPE8"/>
    <dbReference type="KEGG" id="pmac:106710894"/>
    <dbReference type="InParanoid" id="A0A0N1IPE8"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="14568" checksum="DAEC3A0089FA938F" modified="2015-12-09" version="1">MDTKKFTRKEIAERDTKAETVFVIANKVYDVTKFVDDHPGGHEILVNTAGKDASEQFEDAGHSLDAKELMKKYYIGELVDQDKRHNIDRNVNWNLPPVSEESASGFLTSWKFPAALGLLLTLLYTYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQB1</accession>
    <name>A0A0N1IQB1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459838">
        <property type="protein sequence ID" value="KPJ19753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQB1"/>
    <dbReference type="InParanoid" id="A0A0N1IQB1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ19753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="267" mass="29673" checksum="00ACE83A4684FFBF" modified="2015-12-09" version="1">MESSSLESDSTEVFPEDKTKKGEKSYKVRNGSQRYPFSVSVQRKGSHYATGALIEKKWVLTVAGEFYNVRESIKFFRVRLGTVNCKKGGVLLPIKGVEIHPAYSYKNPTYDVALLRLAVPAEYSDTLKPIPLTRIKGKVLSAKFLATYWPRLIVRGQVLPSSAQERVQPNSMRVSTQKMIPWSWCQSLMSTLNQTLDESSLCLDPIMSHHSLCLPDAGAPVTADDGLWGITSGWTSDNCLGNPSPTIFTRVSSPVVRAWLDSQLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQR0</accession>
    <name>A0A0N1IQR0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Piwi-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01056970">
        <property type="protein sequence ID" value="KPJ21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQR0"/>
    <dbReference type="STRING" id="76193.A0A0N1IQR0"/>
    <dbReference type="InParanoid" id="A0A0N1IQR0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="98" mass="11334" checksum="BC2148C3021F80FA" modified="2015-12-09" version="1">MFPRDTKRLPGSEQATDFMICLVPELCQLTGLTDDQRSNFRLMKDVATYTRITPNQRHAAFKKVPFSISVIIFSLKTQRKVKKSSRYNVNCFGLNMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFS6</accession>
    <name>A0A0N1PFS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_01810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460731">
        <property type="protein sequence ID" value="KPJ12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFS6"/>
    <dbReference type="KEGG" id="pmac:106713387"/>
    <dbReference type="InParanoid" id="A0A0N1PFS6"/>
    <dbReference type="OrthoDB" id="7390946at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="176" mass="19435" checksum="C10E469C1C0038D9" modified="2015-12-09" version="1">MRSEVIDENTLTDSEEDLIDDVISESLNDIVVYLFYGCIAMLLLVFTATTLRMLILGQKTRNPQQRRQYMGSRSRTSLPQPDPTIYVSPANLPPPPKYEAMAPPSYEEVVGIHYPNYQPPMQPIAQPIATAMAQNASANVDTEAATDRDNDNPSNTQTTLTVTNERTNTAVVAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGN0</accession>
    <name>A0A0N1PGN0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_03928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460635">
        <property type="protein sequence ID" value="KPJ13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGN0"/>
    <dbReference type="InParanoid" id="A0A0N1PGN0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="356" mass="39056" checksum="2B3E50D9474E0F72" modified="2015-12-09" version="1">MATTVMKVEYENETCAICGSAGDLRSPDEHDAGAPPLQVPLRSMLLQLNNNKVVPEGKLCIECIRRAIEAYEFSTALNTKGAPPLSEKIRALRRKLHELTQKIDVFIVVGGPGVNSGGTYSEDDIIMVERDALAAAAAADDEDLEQARNACGETVYQCSVCPLSFQRASEYRTHISQHPGGARHSCWTCGAQFATRASLTEHTAMHAAPDITSSTCRLCHTNFQSASELRRHEATCEARCPLCNVTCSSRAALSAHAQAAHTTPPLLCGACFRTFNTRELLAAHRLRHRHADRFVCGYDSCILRFATSSAILHFLRPRRSIDPCCIVLHAVPSAMKSQNTSKKKDLKANQPRRQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PGX3</accession>
    <name>A0A0N1PGX3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_04470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PGX3"/>
    <dbReference type="STRING" id="76193.A0A0N1PGX3"/>
    <dbReference type="InParanoid" id="A0A0N1PGX3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="12">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ14610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="329" mass="37720" checksum="560E60739EAA8508" modified="2015-12-09" version="1">MLLLLLLVGLSAGVPQKPNLDAILNRRTDVYIAGFFPFGKGVENSNTGRGVMPSVKLALDHVNEHDSVLRNYRLHMWWNDTECNAAVGVKSFFDMMHSGPHKLMLFGAACTHVTDPIAKASKHWHLTQLSYADTHPMFTKEAFPNFFRIVPSENAFNLPRIRLLQHFNWTRVGTIYQNEPRYALAHNRLLADLDSHGFDIDETQSFATEVRTALEKLKEKDIRIILGNFNETWAMKIFCEAYKLEMYGRAYTWLLLGTYSERWWLKRGPCARSELTAALDTALLTDLLPLSTTGETTISGITAKDYQIEYDRRRGLEYSRFHGYTYDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHR5</accession>
    <name>A0A0N1PHR5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Collagenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_01982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460140">
        <property type="protein sequence ID" value="KPJ17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHR5"/>
    <dbReference type="FunCoup" id="A0A0N1PHR5">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHR5"/>
    <dbReference type="InParanoid" id="A0A0N1PHR5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879786" evidence="7">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="53"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="254" mass="26553" checksum="76151B1D7C64AA40" modified="2015-12-09" version="1">MKLLLVAVCCVVALGCAGAEVPIVLHYHESEGIQKAEQIRQSEVAADFDGSRIVGGSQANLGAYPYMGGLVITLTNGRTSVCGSSLLSNTRLVTAAHCWWDGSSQARQFTVVLGSVRLFSGGTRINTNRVQMHGSWNPRNANNDVAVITINSVNFNNNINRIALASGNSDFAGTWADAAGFGITRDGAGIGNNQALSHVRLQVITNAVCRNTYGSSIIVSSTLCTSGANGRSTCGGDSGGPLVANNRLEILLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJH0</accession>
    <name>A0A0N1PJH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 1-like, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJH0"/>
    <dbReference type="FunCoup" id="A0A0N1PJH0">
        <property type="interactions" value="1675"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PJH0"/>
    <dbReference type="InParanoid" id="A0A0N1PJH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="342" mass="38678" checksum="7C8D3FD919BFAE32" modified="2015-12-09" version="1">MEEAKRLHEIKPIVNVLDQRIALFDSIESLKELNKRDAQDDEMKKLIKEEAQLYLMRVKEIDNELQSILLEPYLTEGGVMVEVVAGAGGQEAMLFARELFALYESYANYKDWEVNIASLEPSDIGGIRKGSMLINGYGAPELMRMEAGVHRVQRIPVTEKGGRIHTSTVSVAVLPQPTEVELDIPDRDLTIETKRASGAGGQHVNTTDSAVRILHVPTGTVVECQEGRSQIKNKQIALQKLRTLLLQKQLEEQSSKIDSERKSQVGSMNRNEKIRTYNYPQDRVTEHRDGGGSLHNLKGFMEGGEPLEQLQTSLLRHQRYQIIMSEINDFINRQKQESSDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJQ4</accession>
    <name>A0A0N1PJQ4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide peptidase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01001949">
        <property type="protein sequence ID" value="KPJ20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJQ4"/>
    <dbReference type="InParanoid" id="A0A0N1PJQ4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="117" mass="12991" checksum="EB8B517323F3B542" modified="2015-12-09" version="1">MPGLLLCFVLRYDAYKKATLVCQMGQVPGPRSMGSRLTYFHCSLLGYFLGLLTATVSAEVFKAAQPALLYLVPFTLLPLLTMAYVKVKQNYDSYIAQFDFVLSSGVSNCHTFIDTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QK94</accession>
    <name>A0A194QK94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ05993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QK94"/>
    <dbReference type="KEGG" id="pmac:106720285"/>
    <dbReference type="InParanoid" id="A0A194QK94"/>
    <dbReference type="OrthoDB" id="7401204at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ05993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="11097" checksum="FB2BE75C7E743143" modified="2016-10-05" version="1">MTYPVVYIIPGQREAYQQMFCINPSEVNKAVTTVCDWAAPPQVQFTLGDEYMHVVRVDPTGRYQGNAVITTYQLCSHNIQHDMLNVTMAPRVVEIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QKK6</accession>
    <name>A0A194QKK6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QKK6"/>
    <dbReference type="STRING" id="76193.A0A194QKK6"/>
    <dbReference type="InParanoid" id="A0A194QKK6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17164" checksum="9BE905335DD6B56A" modified="2016-10-05" version="1">MDLQNLNAEKENEKSYKKINFYGMSKLCNILMVVELSHRLKDTGVTANSLHPGLVRTDILNDINVFGFQLLLPLVKLFTKSAWEGAQTSIYLAVSPEVDDISGKYFVDCRVKKTVKRNGYDLELAHKLWELSEKYVGLKADHLEHCVQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM30</accession>
    <name>A0A194QM30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM30"/>
    <dbReference type="InParanoid" id="A0A194QM30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="10566" checksum="07C8E86027E5F6F4" modified="2016-10-05" version="1">MSSIEHGIHKITQQHKSGGTLAKAGAPVPSGRSATVHGSANRAPYPDEIDSAKTRAPPIVSISVRGRVALISLKLRSVAISAPTRCALLPPRAVATAERLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QM33</accession>
    <name>A0A194QM33_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QM33"/>
    <dbReference type="InParanoid" id="A0A194QM33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="128" mass="13650" checksum="54FF63541C7E4D56" modified="2016-10-05" version="1">METATLNVCIHANSEADCIPLTLAPYFSTTLNERTASSALISVGALRLCGSADLRICGSADLRMGARARGREGAGALRLCAHTRVERKAGTLAETGFRLIHCSIIEDDRHNYALVFYKPKANATVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMT2</accession>
    <name>A0A194QMT2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WASH complex subunit CCDC53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_11331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461194">
        <property type="protein sequence ID" value="KPJ06832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMT2"/>
    <dbReference type="FunCoup" id="A0A194QMT2">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QMT2"/>
    <dbReference type="KEGG" id="pmac:106719492"/>
    <dbReference type="InParanoid" id="A0A194QMT2"/>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="170" mass="19502" checksum="D52263ABCA092607" modified="2016-10-05" version="1">MQDILSNQEIDKLDLSKIAALQQKRTLAFLNHFVITTVQFLNTFAKKCEKKLMQFEQKLEKVEAAMILLEARLSSIPEINETLQTDTNVESLNTSEIKSEDRTDDTKKEVKEIEDKPEDNVSQTTTDTVIKPEYERFIKLVQVGVPLQAVKLKISIEGLDPDEFESMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QNH3</accession>
    <name>A0A194QNH3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_14264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QNH3"/>
    <dbReference type="InParanoid" id="A0A194QNH3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008264504" description="Single domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11840" checksum="3D5709A3FFA7E917" modified="2016-10-05" version="1">MEFRKLLIFFMFILCCVSVNNGYPAPNVFLQRGVKLHDRVKCQYEEPTEDMVCLEHCLPKGYSFGFCNITSLEEWHVNMKKPQTTSCARNIVCPKDIRMASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QP89</accession>
    <name>A0A194QP89_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysocardiolipin acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QP89"/>
    <dbReference type="STRING" id="76193.A0A194QP89"/>
    <dbReference type="InParanoid" id="A0A194QP89"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="329" mass="38688" checksum="7663F91169E20563" modified="2016-10-05" version="1">MALGVAICGAWYYTILSGFYVLYCPVMYLMFINHSLYRKVVDVLFSLWELYPVALFQWCYHTRIRCFGDYVNPNENTIIIMNHRTRVDWNYTWLALYHATKPTDQRVKNIENRDSDDIFDIICGGKSRTKFVLKDEIKIVPGLGWIMQLNYFLYVKRNWQEDQVNLSQFVDYYNKLECRNRIVLFPEGTDLSDDNKRRSRKFAEANNLQCYEYVLHPRTKGWVALCSRLRSSGLTSVYDVTVAYDNPANELDLIRGKLPQEVFFHFKRYSIEEIPINEEEIKTWLNERWQNKENSLRKFNSNAAVSIMTAASLGLPAVINHLGDSGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPY8</accession>
    <name>A0A194QPY8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cohesin subunit SA-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_08437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPY8"/>
    <dbReference type="FunCoup" id="A0A194QPY8">
        <property type="interactions" value="1263"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QPY8"/>
    <dbReference type="KEGG" id="pmac:106718945"/>
    <dbReference type="InParanoid" id="A0A194QPY8"/>
    <dbReference type="OMA" id="QIQEAAY"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131457" checksum="C7D12779FB5BF8BE" modified="2016-10-05" version="1">MHRRGGKRIRMDDPPPEYVNPMTPATPMTDYGGQSVHEPETPHPNYSGFKIGTAANSTAVEAAREEVEEHQEEDGRSPSPAPTKRITRSRGRGGDGGYVGRLAESPPPPPLRRRGRGGRGRGRGRGAAPPPASSPPPILMPGDDENSLYNILRFNKAAINQVVDMWIEEYKTNRESALVQLMQFFINSSGCRGKVTPDMASMDHTLIIKKMTQEFDEESGEYPLIMSGQTWKKFRSSFCEFIQTLVKMCQYSIIYDQYLMDNIISLLTGLSDSQVRAFRHTATLAVMKLMTALVDVALLTSVNCDNCLRQYEAERLKARDKRASERLEVLVAKRQELEENMEEIKNMLSYMFKSVFVHRYRDTLPDIRAITMAEIGIWMEKFPAHFLDDLYLKYIGWTLHDKVGEVRLRCLQALQPLYECEELKGKLELFTSKFKDRIVSMSLDKETEVAVHAVKLVIAILKMHPDMLVDKDCENVYELVYSSWRSVAAAAGEFLNVRLFRSEEPAAAPQRSRRGKVRLPNTPLLRDLVQFFIESELHEHGAYLVDSLIDSNPMMKDWECMTDLLLEEPGPDEDPLDNRQESSLIELMVCCVRQASTGEPPVGRGPARKNQLLSKEQAKMVNDERARMTTHFMVVLPTLLEKFRADPDKLANLVAIPQYFDLELYTTQRQEANLTLLLNKIREIVRQQTECEVLETCGRTLEYLCSEQCAVYSRCKVARATITDMCVDKYREAIDEFRTLIEGGETPDADEQFSVTNSLRKVSIMYMCHNLNDNNIWDSLFEDLPKCLDKDDPMPKLALVYVVRACFYSLLWSLHELEERGTGADLLRDRLHGYCAHCRDIVARGTTAQLRSEAYTSICDLLILFAEQLHSRHHPGDERYRRLVYEPDATLCDLLNDFIQEFVFVLPNYENQDERRIEELHKRRNFLAAYCKLIVYNVIPIRRAADVFKHYIKCYNDYGDIIKCTVSKTREMSKLNCALTMQLAMQALFSDMLRHQPAPHRALPDLVEIKELAKRFAVMFGLDAVKNREALTALHRAGIAFAALEGAGAGPPPNLLFLEPLSEFSNKLLRQDKRQVLKFLDSRLQPTSAWREEWSALQTYRGSLLSDAPDDRPPPPARRHYTRRARAGAGAGHNEEEEGEEHADSDQEHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQ24</accession>
    <name>A0A194QQ24_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_08477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ461185">
        <property type="protein sequence ID" value="KPJ07464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQ24"/>
    <dbReference type="STRING" id="76193.A0A194QQ24"/>
    <dbReference type="InParanoid" id="A0A194QQ24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ07464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="531" mass="59833" checksum="8935C2AB7FFCBFEE" modified="2016-10-05" version="1">MDSTKFSSFFGNVPTFTIPGRTFPVETFFSKNVCEDYVDGAVKQALQIHLQPDDGDILVFMPGQEDIEVTCEVLTDRLGELDNAPPLTVLPIYSQLPADLQAKIFQRAPPGQRKCIVATNIAETSLTVDGIMYVIDCGYCKLKVYNPRIGMDALQIYPVSQANARQRAGRAGRTGPGKAFCLYTQRQYTHELLPATVPEIQRTNLANTVLLLKSLGVRDLLAFHFMDPPPQDTILNSMYQLWILGALDGTGELTALGRQMAEFPLDPPQCHMLIVSAEMGCSAEVLIIVSMLSVPSVFYRPQGREEEADAAREKFQVPESDHLTLLHLYNQWKANNYSSSWCTQHFVHAKALRKVREVRQQLRDILQAQRLPLVSCGTRWDTVRECICSAYFQQAARLKGIGEYVNCRTGMPCHLHPTSALFGLGSPPDYVVYHELTMTSREYMHCVTAVDARWLAHLGPMFFSVKETGKSNRDKKKEAAVHLQRMEEEMKEAEQKMAEEKRKRDEEVPVKQEIATPGLNTPRRTPHRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSL2</accession>
    <name>A0A194QSL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THO complex subunit 4-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_12266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSL2"/>
    <dbReference type="FunCoup" id="A0A194QSL2">
        <property type="interactions" value="1691"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QSL2"/>
    <dbReference type="KEGG" id="pmac:106717812"/>
    <dbReference type="InParanoid" id="A0A194QSL2"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000273">
        <property type="entry name" value="THO complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="256" mass="27272" checksum="3250D4FB0C66A898" modified="2016-10-05" version="1">MVDRIDMALDDIIKANKKGRGGGGAGRKFEVKKPGRGAGGSFRSNRAGGVLRGRNRGGVTKSTNYTRGDVNSTWKHDMFNDFNERKLQRSAPLTTGPTKLLVSNLDFGVSDSDIQELFSEFGILKSAAVHYDRSGRSLGTADVVFERRADALKAMKQYNGVPLDGRAMNIQLATSEITTFRTEERNRPVGGGGGGPPRRNINRGGGANRSPGSQRGGARRGGRGGGAGGGAPRGKKPVPTVEQLDAELDAYVKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTB5</accession>
    <name>A0A194QTB5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTB5"/>
    <dbReference type="STRING" id="76193.A0A194QTB5"/>
    <dbReference type="InParanoid" id="A0A194QTB5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="20925" checksum="12D4538BD5BED846" modified="2016-10-05" version="1">MALSSIIRRTFINGALYSAAALRFASTQQEKKVYFDVTADGEPLGRIVMKLNADEVPKTAENFRALCTGEKGFGYKGSSFHRIIPDFMCQGGDFTNHNGTGGKSIYGRTFMDENFKLRHTGPGILSMANAGPNTNGSQFFITTVATPWLDRKHVVFGSVVEGMDVVKKMENLGSRNGTPSKKVVIAECGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTC9</accession>
    <name>A0A194QTC9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTC9"/>
    <dbReference type="KEGG" id="pmac:106718216"/>
    <dbReference type="InParanoid" id="A0A194QTC9"/>
    <dbReference type="OrthoDB" id="7475597at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="203" mass="22944" checksum="5D3491CE1DEB5E23" modified="2016-10-05" version="1">MRDIVAATFANPAAPQAPARNPSPDTAPHKPASIPSSIETFNSHRKIRRPKLGDKKVYRPVRRNTLSRIDEAPPQTRPRSKSLQISTDFSSTRPMVRSRSNMSMDTSRSIPACSYSTQNQLETSSPQYAEPRGYDSSSSCERPASMTDLPIMIPLDPVTGAYIPYPEYSYYQDDSGRVNRYKWKRNRGIKTSKSNNLFLAFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU64</accession>
    <name>A0A194QU64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_12283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU64"/>
    <dbReference type="FunCoup" id="A0A194QU64">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QU64"/>
    <dbReference type="InParanoid" id="A0A194QU64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055445">
        <property type="entry name" value="ARM_ARMC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312:SF8">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312">
        <property type="entry name" value="ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24768">
        <property type="entry name" value="ARM_ARMC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC5-like ARM-repeats" evidence="3">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="663"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="840" mass="93713" checksum="B28263955DC17517" modified="2016-10-05" version="1">MDETSSLMVGKLNIFGPLISILKTVYRDSILGRTCRLIGNLAQRHSNAKGLHDHGAVEVLVTLIENRDKNTSIATLTMAVRAIRQLWMVTDKRDEMLSVNAVRCITVLLTAQCESAGIIESPNPTNEVDELKKSHEELINGILKCLGYFTTYSNPQCAEQIQGDGRGYKCLVALTKLFESTALKCLINLCYVPSCRPLLGTAGLVECLVGILQKLSDVAWWPEGSAKALALLSSDSVNRCRLRHCGGLPLLVSAARIVDGRSQKRPDDVNWERKRNEMVCKVLSEIPMSPDCSDAYPMSPYSDTNQSGLASPEYGPTRKRMRWDWSPESSVSAGEGSSASPYWADWSPQSSSCPTSPYSINEDSADSEISGRYSPVCSEPEIDDGAGKMTANELLALEVTRVDHDLDEFDMADDKSDDDQETSQEDVNKFNVNTKLSDISCVLVLLFRVSHGASYDTQQEMDPIERIDLLAGHDCLNGLLNYVERCKSPLGNPARILKKVLSSARCFMNVLKHRFPLRLYNMTQNSKHPRNECIQCMQVVKLSFKLLARLTVLAESSYGIGEISYQLLKGSQDMKRTLSITLPYIVSTAKPLKKYFIDCNALNVLLTTISESKEDNEIGITGLVKLANNIHIKDPKMLENRFKDKVSVSYDPILDNLLVDDVVTFELDDLSTVRANKLFLCQNSDVFSAMLMGCFKESGESCVRLRKASKSALEYLFTLLQCGLNNPKSDIIIFPMAENLETSLETLLLADRFLFERIKDILSSGIVQFQLCAESAERIYIWSLGDGMGFLCVEAAAYLLTGEMSAMQRTRSFTNILSLKYRDQWLDDIKSMIMRQLVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUG9</accession>
    <name>A0A194QUG9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_15314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUG9"/>
    <dbReference type="FunCoup" id="A0A194QUG9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUG9"/>
    <dbReference type="KEGG" id="pmac:106717275"/>
    <dbReference type="InParanoid" id="A0A194QUG9"/>
    <dbReference type="OMA" id="NTACIIA"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="544" mass="59809" checksum="3CB1789C725E60BA" modified="2016-10-05" version="1">MTATHGGGCEDARPDKDYTNKTGFKNDAYQHDRDSNDDIVKPPPLPTEEDMYASGKVKLSRNEKWRILKNVAAVSAAFMVQFTAFQGTANLQSSINAADGLGTVSLSSIYAALVVSCIFVPTFLIKRLTVKWTLCLSMMCYAPYIGAQFYPAFYTLVPAGVVVGLGAAPMWTSKATYLTQAGSVYAKLTDQAVDGIIVRFFGFFFLAWQTAELWGNLISSLVFSSGVHSGNSQNTSNTLLTCGANFCMIGGGHHDNRNLHRPPDSEIYEISAIYLACVVVAVIMVAVLVDPLSRYGEKQRNSDPSRELTGIQLLSATAYQLKKPNQQLLIPITLWIGMEQAFIGADFTQAYVSCALGIRSIGYVMICFGVVNAICSLLFGSAMKFIGRFPILFMGAALHLGLIVWLLIWRPNPESPTVFFVISGLWGVGDAVWQTQINGLYGVLFRRNKEAAFSNYRLWESAGFVVAYAYSTHLCARMKLYVMMVVLLIGFLGYMVVEILHKRKALRLKAIAENPAAAADAAMQPPEEDDEKDEIDDEIIITHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN4</accession>
    <name>A0A194QUN4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_07682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN4"/>
    <dbReference type="FunCoup" id="A0A194QUN4">
        <property type="interactions" value="2456"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUN4"/>
    <dbReference type="KEGG" id="pmac:106719210"/>
    <dbReference type="InParanoid" id="A0A194QUN4"/>
    <dbReference type="OMA" id="WHSPQAW"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="707" mass="78862" checksum="D67E828C0243D065" modified="2016-10-05" version="1">MIVQDPIQVIVWDCLNNYEYDNAIFLAERLHAEVASEETAFLLGTCYYRAGRVNEAHHLLQTISLTLPQSRFLLAKCAIELKSYKDAEVILGTNMDIVASEFGEQAPYALQLLAKIYNITERRNKAADAHRKALSLNPFMWKSFAQLCNMGEKVEPHQVFHHSNTDFSFGVSTLVNLVSNSENISFVNSNIPNNTSLNTNVTPNNMSSKTPMIMSTSITPEPQAPVKRMHSVFSGMAPIPFSPSFGMLPMDESPVLYTPTLTDSNEQKALPKIVNSLRAQMGQLKDAVFSPAPRCTLGPAPRRSSRLFSNNNSSYSVKENNKSPSRKFVAPKSPSRKSKQRTAKNIKSNPVETNERAKSIETVTPAITPKNSNAVALLNLLKELGEAYKALSFLDCKNAIKLFQEIPSKQLASPWVQTMIARAHYELAQYEMAAKVFAEIRKQHPNRTEGMDIYSTCLWHLQREAQLSALAQELVELDRNDSIAWLAAGNCFSLHKERETALKFFKRAVQINPDAAYAHALLGHEYAAAEETDKALASFRTAVSIDPRNYVAWFGIATVYARQERWKASEVHIRRALAIHPHSGVLRCQLGVAQAALGKMDRALATLERAVALDTENPLCRFHRASVLLRAGRPDDAIDDLSHLKNIAPRESLVYYLLGKAYNKIGNPHMALMHFSWATDLDPKGTGGHIKEGFDPSKQEDTPERAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUQ1</accession>
    <name>A0A194QUQ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUQ1"/>
    <dbReference type="InParanoid" id="A0A194QUQ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="18949" checksum="E5DFBA10709A0A93" modified="2016-10-05" version="1">MNVFVVEYSGFVAANQPGAGTRSMNTESLKSRDRLLDGKSCESFRKARAKDCENVASSLAFRTPHAYISSKMQFSTIIVLVCLIATVVASVHYERRADADTRDFSPYDPLDGSSDLKRSPRMKRGLLLLKKKLLLGALGLKAAKVGAVGAGLAGALALKSKASVPHSEKIHIYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVK0</accession>
    <name>A0A194QVK0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Breast cancer anti-estrogen resistance protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVK0"/>
    <dbReference type="FunCoup" id="A0A194QVK0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVK0"/>
    <dbReference type="InParanoid" id="A0A194QVK0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10337">
        <property type="entry name" value="SH2_BCAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000013">
        <property type="entry name" value="SH2 domain-containing protein 3C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000015">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044102">
        <property type="entry name" value="SH2_SHEP1/BCAR3/NSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF8">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="353"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="639" mass="71392" checksum="9311B108B930EA68" modified="2016-10-05" version="1">MTTSGLLDWELSLPSDQIISHGWYHGALSRTAAENLLQQDREFLVRESSSQPDNYVLSCRSNGQHLHFVIQRIVVHPETVYEKYQYQFEDEAYDTVADLITSYVGSGKPISAASGARIQYPANRVVPLTNYTADDMTSAASPMGESSGYGNPYSLYSHFAAKPGMQLRVPFKKQRSHSLTPIDISQHVTHGKSASADGVIQSQTNKHHKHLSGDSNSNSGTWDANLPTSPPAKPVRHEGPKADDRRLELQRFYHVSGSDSGNGSGDSTQSSAHSDPNKSRMETDYNLVTPTIKQEFDYDGTEARLIKTVKFDYMVESRINLENFQSQIIPTNLTKPLESETLHTIKLLMRTCGPRILANHMTKVDLHFLIDDAVQIEGMDRTASGLELCFLPQGRSLRMDVIERVETLRLFIAVTILTCQTDRQRADTINDWILLAVETKTALGNLYGFSAIMFGLCMPQVECLENAWSILRQVYTDSAIMFEAKLRPCFKSMNEGTNPLPPNTTTPNVLPAVLLCHKYDGEGGSAIPPDETFPNSLMNTVKYDFTTTFAHLDAVRHFADQVDTFKRNGRTVIQVMSQLGPVLDPILLELFKTEFHINFLWGERGALITPSQRFARLTDVLTSMAAKLVNQPPLQEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXE5</accession>
    <name>A0A194QXE5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoglobin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXE5"/>
    <dbReference type="FunCoup" id="A0A194QXE5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXE5"/>
    <dbReference type="InParanoid" id="A0A194QXE5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="190" mass="21939" checksum="CF1163E6AA821672" modified="2016-10-05" version="1">MGGWLSHLWWGGDPDKVNHVSGLTRREIYAVQKSWAPVNKNSVATGTELLKSLLFQNYGAQFNEPIKAILFFRAYPNSKDFFKMISKLPEEEYSKNFQFKAHVINLMATLNQAVTNLNQPEVVAVMMNKLGESHKRRKIQEQHFNDLKEVIVKMFIEVLKLDDSTLGAWGKTVGFWYKHIFETLNTQEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QYV1</accession>
    <name>A0A194QYV1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like subfamily C member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_09603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460949">
        <property type="protein sequence ID" value="KPJ10469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QYV1"/>
    <dbReference type="STRING" id="76193.A0A194QYV1"/>
    <dbReference type="InParanoid" id="A0A194QYV1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C GRV2/DNAJC13 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GYF" evidence="1">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="723" mass="81012" checksum="EAE1927346446921" modified="2016-10-05" version="1">MQHWAQRARSLGVAGAGTGAAVAGGAAGERRERPVLLRRRRECIKSTYNWPLFYYQFHRDHALPNLIWNHTTREELRNALENELRAFTSDREVAGGALTSWNHAELEVHYQCLQNEVKIGDYYLRILLEQRDNDDSPIRKSYEFFNDLYHRFLSTPKVEMKCMCLQAMTIVYGRYYEDIGPFADTKYIVQMLDRTCDRMERDRLVQFLAKLILHKKNVSEILEWNGIRILVELMTLAHLHTSRATVPAQSNVLEAGVQQAGAGEREWYYNLEMPDKVHRKGPVSLQQLKDLYKSGEINNKTKCWANSMEGWRAVGSVPQLKWTLVARGAPVMDESALAATILDLLIVCTRYYPSRDEEDAVIRPLPRVKRILSEPSCLAHVVQLLLTFDPILVEKVATLLYEVMQDNPEISKLYLTGVFYFMLLYTGSNLLPIARFLRLTHMKQAFRADQLWYLLLVLAPYKYAGYPQLLRTARLEVEAEQLFAERDAALLPAACQLAHATVRCSALNAEELRREGGLQGSRGETCARALAALLRAKPALGEVCAQLGELPRLARLLPSCPKHAVPVLAALADTQSCVAALTQTEVMSGLKTAVKTCREVVGTTCEALAAIFNNTNPNTDKLVLQALECELISELLLALESRLEGQAAAQLVGALKGMARSAAHGDRVRALLARSRVWEQYAAQRHDLFISSVPHTHAISAPHAAGYLTAPPASIPAQPPPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZA0</accession>
    <name>A0A194QZA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_10048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZA0"/>
    <dbReference type="InParanoid" id="A0A194QZA0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="584" mass="67253" checksum="4FFB623ABB55319B" modified="2016-10-05" version="1">MESDDRTIAEGLSFILNLYISESDDYAKQVCEECYAVILKFDQFKKRCIQSEGSLDDAYYAESNVNIPVSQDNKSTKEVSITKFSMDEPYQCSVCSKKFSDLLLLESHVLNGHSFANDRLIKDVNLTEAITQDPDYQTYTSPYNNSGLENDIEIEFKPKDEINEGFGFADSTGDIQCPILDCNAKDEAEVTEQVTTSNVLYKCKCEAIFDSCDKYKEHLNKKICKETFNTIRTSRTRKVKEKKSDEKVESVCPKCNVKFISLKRYKMHLRMHQIENTHPADKFSCSLCLRRFTYKHSYTAHMKTHKVKEGVKFICNTCKREFQHQAHLDNHILSVHTRETGFKCEYCAKNFSTQESLDNHREAHKVEKRHQCPVCNKAFYVLSTLKDHIRTHTGEKPFLCSDCGKGFSQKNNLTQHMRRHQGLKLFKCENCEQRFVSKGELVAHNRKHSGAHPFVCDECGNSFTTSSSLSKHRRIHTGEKPYACDLCDMKFTASGTLKNHRRRHTGEKPYQCSHCEKAFTQRQDLVSHIRCHTGERPFVCSTCGQAFRKATALKTHLKMHEKDTIYLQKDVTLSIIHNANALIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZW7</accession>
    <name>A0A194QZW7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">RR48_06314</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">Ya'a_city_454_Pm</strain>
            <tissue evidence="35">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:19466"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 37">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KQ460947">
        <property type="protein sequence ID" value="KPJ10520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194QZW7">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZW7"/>
    <dbReference type="InParanoid" id="A0A194QZW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20910">
        <property type="entry name" value="NCBD_CREBBP-p300_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15557">
        <property type="entry name" value="PHD_CBP_p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15802">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02337">
        <property type="entry name" value="ZZ_CBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1020.10:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.40:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000003">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000001">
        <property type="entry name" value="Histone acetyltransferase p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1630.10">
        <property type="entry name" value="Nuclear receptor coactivator, CREB-bp-like, interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009110">
        <property type="entry name" value="Nuc_rcpt_coact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014744">
        <property type="entry name" value="Nuc_rcpt_coact_CREBbp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037073">
        <property type="entry name" value="Nuc_rcpt_coact_CREBbp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056484">
        <property type="entry name" value="PHD_P300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09030">
        <property type="entry name" value="Creb_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23570">
        <property type="entry name" value="PHD_P300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69125">
        <property type="entry name" value="Nuclear receptor coactivator interlocking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0010">Activator</keyword>
    <keyword evidence="22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="17" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="18 25" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="28" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12 26" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 27" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="31">
        <location>
            <begin position="330"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="KIX" evidence="33">
        <location>
            <begin position="567"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="30">
        <location>
            <begin position="1004"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="CBP/p300-type HAT" evidence="34">
        <location>
            <begin position="1224"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="32">
        <location>
            <begin position="1606"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="31">
        <location>
            <begin position="1668"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="26">
        <location>
            <begin position="330"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="26">
        <location>
            <begin position="1668"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
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            <dbReference type="PROSITE" id="PS50014"/>
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            <dbReference type="EMBL" id="KPJ10520.1"/>
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            <dbReference type="Proteomes" id="UP000053240"/>
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    <sequence length="1959" mass="214448" checksum="64B218CAD380DF41" modified="2016-10-05" version="1">MADHHVDEPPNKRAKMIRDPFQGPSDTAVDGFSNLDMFDLEKDLPDELMAGSWGEQPGVTGPKPPAQGPGPGPQMAPQQQLNGDDPTAAMHRHINSHLIQQGNKSGLVGHNNPLGLGTLGSKSPNLQSPPNVNVSKDLMGNLHPQLMPNTSHPNQLHSNMPMSSIQGGMNVTNVGGNMIVTNSNMSGAGMLGGGIINNVNKLSTLVTNNHHPSAPHHPHTQVMQNGPLGGRVGVGVGMRGGLQHVGRMTAPGGGGHPLAPYHPTYAQSPPARCPPGVRFGPPDAGAPAGGAAPAVPPAPSPQTPGAPAGGQSQPQAATQSAAPPSGSIADPEKRKLIQQQLVLLLHAHKCQRRESQSQNGETWQCTLPHCKTMKGVLNHMMSCQAGKNCAIPHCSSSRQIINHWKHCNKNDCPVCLPLKQADRRSSTMNPIVSHATTGAVGGGPTGGAAAVAGTGGAGPLSAPLSGGVGGVAGSGGAGAPAPGDMKRAYEALGITCPTSMAGGFRGGVARMAAPRPALPDAPQPTLQPLYAQQTMPDLQQQQQQQTQLMTTGTLQLPGGPVTANPVSGTKEWHQSITADLRNHLVHKLVQAIFPTPDPTAMLDKRMHNLVAYARKVEGDMYEMASTRSEYYHLLAEKIYKIQKELEEKRQKRKEQQQLQQQQQQQQQQQQQQQQQQQQQQQMQQSGVMSAGVLGVRAPGGVIGPGPGSGVGPNVVPGVVSGVGLARSAPPGLGLRIPSPGMTLPMPASRMAFQNNLVGPPGPSPNQMPQTPNGGSVGVGSVGNPGMSPFGQPMTSPAPQYQSMQTNGPAPLASPNHQQETKVRLSGGPVASPFMNHSSFRSDQSTASPNPVNSAGPPPPGTPATPHTHPHPSPAPDPRPISRPASVSAQKAALNAAASAEDSPEDVRIKQEQDDMRIKEEPDEDSGGKGMRAETPGDKDSMDRTDRYPDFVVKQEIKQEIKEEPSEGPASVSSVEPDRGPKKMFIFKPEDLRQALMPTLEKLFCLDPESLPFRQPVDAQALGIPDYFDIVTKPIDLSTIKMKLDRGEYKDPWEYVDDVWLMFDNAWLYNRKNSRVYRYCTKLSEVFEQEIDPVMQNLGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYFSYQNRYTFCQKCFNDIQGDTVTLGDDPLQPQTAIKKDQFKEMKNDHLEQEPFVVCMDCGRKQHQICVLHHDQIWPQGYCCDNCFKKKGAKRKENKFCAKKLPTSKLGIYIETRVNNFLKKKEAGAGEVHIRVVASSDKIVEVKPGMKSRFVESSELSPEFPYRAKALFAFEEVDGTDICFFGMHVQEYGSESPSPNTRRVYIAYLDSVHFFQPRQYRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQEWYKKMLDKGIIERIILDYKDILKQAMEDNISSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAVIFQSSEENEQGPDGKKKGQKKAKKSNKSKAAQRKNSKKQSDQQQGSDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLVNCDLMDGRDAFLTMARDRHYEFSSTRRARFSTLCMLYELHNQGQDKFVYTCNSCKSHVETRFHCTVCDDFDLCVPCHEKEGHPHKMEKLGLDIDVDSSPGDMKQANPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVAHTKICKRKTKGDCPICKQLIALCCYHAKHCTESKCSVPFCSSIKQKLKQQKVQQRVQQQQLLRRRVAAMNTRGACAPSSPPHASVPLASPPHTSAPAKPAAHALPHNVQKVLQQVQEEAARQQAPSYGKQAAMGPPGCAGGVRGEWAPRYRAAPPPLHHAPHHAPHHPRLQHHAPQQPPHAAQQQLQQRAPPPPGPQQTPPQVHQKALQQLMATLRSPTSHNQQQEILQILKSNPPLMAAFIKQRQLVVSTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0E4</accession>
    <name>A0A194R0E4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_14811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="VSQIPCF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="122" mass="13763" checksum="7CCED5AD6642C889" modified="2016-10-05" version="1">MDTVVKSMMEEDPEEEKKGLVLFGRDLSTIPCFRESFLYGIGTGVGVGIASFFKTSKPLLSQHIGMGAFTITTLVYWSYCRYNWSKQKFDAQLLQSALKDKIRYEGTGVEKEMEEKGILKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R226</accession>
    <name>A0A194R226_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ and LIM domain protein Zasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_14944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R226"/>
    <dbReference type="STRING" id="76193.A0A194R226"/>
    <dbReference type="InParanoid" id="A0A194R226"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="293" mass="30963" checksum="A2BA066D407A6958" modified="2016-10-05" version="1">MTSAAQRHIKFDEGKNNFFVGNMAQLLTVRLNKSDQQPLGFRLQGGKDFGTPLVVQKVNGGSAAERAGLQAGDAVIRVNNTDVYNLRHQEAQDAIRAAGTALELTVQRGGNTWRPTVTPTGSLPRPGTRPLGAAPAPVTSTSLKATPQPNRNFGSGHNNVAKPFGYMNGTDSGKGLVNKQYNSPVNMYSDKTIAETLSAQTEVLAGGVLGVNFKKNEKTYDAEKSAVFKVLQEEQNDPEPEMGGAPAPAPVSPAPVSGLRHVSAPVAKPDAPLNTGGLPPGQNICEECERLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R250</accession>
    <name>A0A194R250_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460870">
        <property type="protein sequence ID" value="KPJ11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R250"/>
    <dbReference type="FunCoup" id="A0A194R250">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R250"/>
    <dbReference type="InParanoid" id="A0A194R250"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF282">
        <property type="entry name" value="LETHAL (2) 37BB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="425" mass="47460" checksum="E48195E0E83CE87A" modified="2016-10-05" version="1">MLNKKSAIYPEHADVVIIGGGFIGSSVGYWLKTRAGSGLSVVVLEKDLSYSKVQNNISLGTLTQHFSLPENIQLAQYSAEFLRNVKLNLTSDTNIEYKPNGHLILASEKYAERLEKNVAIQKEFGVKNELLMTADIKEKYPWINTTDVKLGCISIESEGVFNPEALLKGLVLKSSDLGVKYVDAEVIGFDMVEQRDVLMEGVAPGDFRKINKVMYRTKDNEEHAIQFAVCILAASGWSGEVAKLAHIGVGDGLLKIPLPVQQREYNIYNIQDENTKASINTPVIMDTSGLWLQHNTLENNFICGYTPLSSNSVKELLTEKFYEEIIRPSLINRYPNFQEHQIKKLQTEVQDCNTYDETGILGPHPYHTNLVIAAGFGKLGCQHSPGIGRAIAESIIDGYYSSIDLTRFGFDRLLIDEPLVEFNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2C4</accession>
    <name>A0A194R2C4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2C4"/>
    <dbReference type="InParanoid" id="A0A194R2C4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="394" mass="44601" checksum="43CCB1A22E55E677" modified="2016-10-05" version="1">MFRKEGGREEEPTNAAEEVQALVAVILMKDTTVEVTVLRQVHVLMSHGERTPSERELAMLGAPPPEHVFAPYGAGALTNEGKMATFEMGALLRKRYNEFLGPYYEDGKHVVITSDTDLSKVSALLISAGLWPPPAEQVWNDTMQWQPVPYSYPPRDTDYLLYEENCPRYNQEKERILQAFTEEGLLAPYRDFFHKIATLTNTNFSTPREAFYLNNLFTIQDDIKVANPKWAKHVKRKLMDVARLEFMMMFHNNLLKKLSGGALLHEIIKESLQSGMPSRSLVVRIGTPVSVAALLAACVAPPPRPPDPGAALIIELHEKLPSKDHKVIDSIAKRYGFKIYYWDDDSAEPRLIEVVGCEPFCSLETFKHLTQQVLSYDYKEDCKLVSTDINKDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R385</accession>
    <name>A0A194R385_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Class E basic helix-loop-helix protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R385"/>
    <dbReference type="FunCoup" id="A0A194R385">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R385"/>
    <dbReference type="KEGG" id="pmac:106713790"/>
    <dbReference type="InParanoid" id="A0A194R385"/>
    <dbReference type="OrthoDB" id="10011855at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18954">
        <property type="entry name" value="bHLH_TS_bHLHe22_bHLHb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000026">
        <property type="entry name" value="Basic helix-loop-helix family, member e23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF104">
        <property type="entry name" value="GH17679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="20744" checksum="12BB56837E8D2782" modified="2016-10-05" version="1">MEGRRSWDGIPLGESHSPPQSVPGRRTPLGAVGLGGFYMQGGQPPPPQHCYPTDENQPEPGTSYAQRPMGEGKGKQKMRQGKTVRLNINARERRRMHDLNDALDELRGVIPYAHSPSVRKLSKIATLLLAKNYILMQASALDELRRLVAYLQSTASAAGIVPPPGFDLTSFPAAAKLLQPPTGPPAPPDPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3I2</accession>
    <name>A0A194R3I2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Laminin subunit beta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3I2"/>
    <dbReference type="STRING" id="76193.A0A194R3I2"/>
    <dbReference type="InParanoid" id="A0A194R3I2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="406" mass="47687" checksum="323A1A12DF8E9AD6" modified="2016-10-05" version="1">MENVVINAYRFSDNDQQRQRPPPEESRNEHMVYFWDLIPIINMSRIVKFFMPKFGIKFTFIQFLQPITKNTYSILLILFNLVLFCEQRLEEIAPAERELFLQSEKVKILEDRINKLQVLLNEQAHEKAKRAERLEIIASEQKKLEEELKHEKEGHDVIKKELEVILNENKQMEIILEQKKTHRDGLIAEVEKLRGQRVYDAEDIKAQVEQATHNVQEAEDKLTSLRATLMQKENYLKNLQAIKPNLTTANNLLHEIMNLTDSLNNYDSDDLDSDSKEGELKVFNTELTELETKLEELIAARAEAANKRKENQVKRQQEKTVALTNLRKAEAMEKEHREQAKKAMQQIEAIKQLTIKYEAEKSEGMEELAKLKYTFTNELKLVEDAMIKKILEAQKMIEDRLRNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3L6</accession>
    <name>A0A194R3L6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3L6"/>
    <dbReference type="FunCoup" id="A0A194R3L6">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3L6"/>
    <dbReference type="InParanoid" id="A0A194R3L6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052821">
        <property type="entry name" value="F-box_only_SRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="573" mass="64945" checksum="560626280C8BDE81" modified="2016-10-05" version="1">MTVCKRWCCCAQNVLRKTSIKLIKAVAEFNILWKNVTSTDIGPTITKRFSHAACILKNNMYIFGGCTTNSTSFNDLWMFDLSKRRWIRPLATGTYPVPKAYTTMVHYQDCLIVFGGWTYPSLSQYYQNITMFNDIHLYCVTTNKWILINATNPPPPMAGHSACIRGDEMIVFGGLVMSAAQNYQMQCSNDVWVLDIVTFNWRKQQTTKPRPSPRYAQSLITLDSERLMLLGGIQTLHNRFVYSDCWILTMQGPTWTWKEIAVKNKEWASANIWCNPACRVGDMVVSLSRSRHGWNGAKPLVTSAVRLSALNRPENAPVSVRIEQSLQRPLDRDQNINGRRGVLPRQPVSRQPPANVNNEPIAGPSTEQESDKDVTNDIASQDTNYAAGPSSDLKLNNNVIDLNKKEAMRKNKTKNKGMKIVRQLQEANKYRMAAFACDSSSNNTPNENDLINQRQIAHLENRLEPYPPAAERPDVVYRQPPVIKRNTLTMHVLDISTVLNGNCMNYVSWLCPRLGDMNGAPEELVMYSLVKGNGELIMFGGVHNEIRVTRFTENPQNMYSNSLHFITAPRDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6K3</accession>
    <name>A0A194R6K3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460685">
        <property type="protein sequence ID" value="KPJ12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6K3"/>
    <dbReference type="FunCoup" id="A0A194R6K3">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R6K3"/>
    <dbReference type="InParanoid" id="A0A194R6K3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF411">
        <property type="entry name" value="GH05102P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="304" mass="33315" checksum="9518044AD4D97AC1" modified="2016-10-05" version="1">MPVCGFLIAHFGWESAFYFTGIIGVMWSVAWFAVVYDSPAQHPRISDAERNYLLKALPQDNNTKGHMPAPWRAMLRSAPVWAIIITHGASVFGYFTVVNQLPSYIESILHFNIKHNGLLSSLPYLGKYLCALASSVLADSLRRSGRLSTTAARKLFTGFAVGLPGVMMIVQAFLGHDRVWSIAIFTLALTINGAVTAGYLGNGLDIAPNFSGTIFGMANTLSSFGGWLSTFMVGELTHENNTYEQWQIVFYILAGTYLLGALCFVTLGSGELQPWNSPAPAATRQEEEPLNEPLQPPQQPHNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R779</accession>
    <name>A0A194R779_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_10862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R779"/>
    <dbReference type="FunCoup" id="A0A194R779">
        <property type="interactions" value="1769"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R779"/>
    <dbReference type="KEGG" id="pmac:106712292"/>
    <dbReference type="InParanoid" id="A0A194R779"/>
    <dbReference type="OMA" id="MPEETCQ"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000030">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="650" mass="69200" checksum="974A1D110C8ABD17" modified="2016-10-05" version="1">MSDSELAYGSSLTVDSIKVIAESVGIANLGDDAAKELADDVSFRLKIIVQDAMKFMHHAKRQKLSITDIDNGLKIKNMECQYGFIQPDSLPFRFASGGGRELHFVEEKEIDLSEILSTPPPKIPLDVSVRAHWLSVDGVQPAVPENPPPLSKEAQKLESVDPITKLSKPSNKDSAGKPVCGKAARLKASESVHVKQLATHELSVEQQLYYKEITEACVGSDEARRAEALQSLACDPGLHEMLPRMCTFISEGVKVNVVQNNLALLIYLMRMVKALLDNQSLYLEKYLHELIPSVSTCIVSRQLCLRPEMDNHWALRDFAARLMAQICKTFNTSTNNLQTRVTRLFAKALQCPSQTNNETGNGPSMVTTMKESEKTPLASLYGAVQGLAELGPEVVKVFILPRVRWLGERVEGALSGIGGADRLAAGNLKHQLLKVLAPVVRQLRQPPDVPDDYKRDYGYLGPSLQQMVIKLRTTPAAGGGGGAVAVVSCTPPLVPHAPPAPSPSPSPAPSSAPSKVAESVARNVVISAPSTPPPQKFVIVSQQKTPQAQVSSSGHIVHTSQPTIVRSQNVQSVVVTSGPPGGAGAGGGGAGGGAPPQKLVVVGVPPQGSASAALPSLSQAPVSVMAKPVFVRAGQPSQPPPELDDLSHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7J7</accession>
    <name>A0A194R7J7_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460627">
        <property type="protein sequence ID" value="KPJ13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7J7"/>
    <dbReference type="STRING" id="76193.A0A194R7J7"/>
    <dbReference type="InParanoid" id="A0A194R7J7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="211" mass="22612" checksum="3817A9387683A3B3" modified="2016-10-05" version="1">MEHAQIQSSEGPQMVTLNGQQMQVLQMSNSPHMVQGPNGQQIVVHTIQPNAQAIQVATPNGQQIQQLQVLPMSSLQGAGNNLQPMQLVQTADGQTFIYQPASAPQPAIDQHQIIHQPVINLNGNLVQLAGLGGAVPQQQLLNQSNIVMMVNGSGGGTSSGAESCGGAGSDEEPLLYVNARQYQRILKRRAARARLHDLGKIPKERPVTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7S9</accession>
    <name>A0A194R7S9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kelch-like protein diablo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_06793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7S9"/>
    <dbReference type="FunCoup" id="A0A194R7S9">
        <property type="interactions" value="1541"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R7S9"/>
    <dbReference type="InParanoid" id="A0A194R7S9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18459">
        <property type="entry name" value="BACK_KLHL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF451">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="489" mass="54540" checksum="65F9E55D3CCA897F" modified="2016-10-05" version="1">MGEGGGSPGGGARLSHTSEKHPRAILGELSALRRHRELCDVVLNVANRKLFAHRVILSACSPYFRAMFTGELAESRATEVTIRDVDEQAMEQLVEFCYTAHIVVEESNVQALLPAACLLQLQEIQDVCCEFLKRQLDCSNCLGIRAFADTHSCRELLRIADKFTQQNFPEVMESEEFLLLPAAQLIDIVSSDELNVRSEEQTFQAVMSWVKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVSSELLIRSDDACRDLLDEAKNYLLLPQERPLMQGPRTRPRKPSRRGEVLFAVGGWCSGDAIASVERFDPQSAEWKMVAPMSKRRCGVGVAVLHELLYAVGGHDGQSYLNSIERYDPQTNQWCGAVAPTSSCRTSVGVAVLDGALYAVGGQDGVQCLNHVERYDPKENRWYHQNCFHLTPVFCVVVVTGRFGPYVHPTDIVVAGSTIALRGQRSFNSNIFNPPLKKLMRLVCTGFDKSDCNITLLQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R8G5</accession>
    <name>A0A194R8G5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Beta-galactoside alpha-2,6-sialyltransferase 1</fullName>
            <ecNumber evidence="16">2.4.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ST6Gal I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sialyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_10729</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;6)-beta-D-galactosyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28034"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:136398"/>
            <dbReference type="EC" id="2.4.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.1" evidence="16"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R8G5"/>
    <dbReference type="FunCoup" id="A0A194R8G5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R8G5"/>
    <dbReference type="InParanoid" id="A0A194R8G5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003835">
        <property type="term" value="F:beta-galactoside alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23968">
        <property type="entry name" value="GT29_ST6GAL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000012">
        <property type="entry name" value="ST6 beta-galactoside alpha-2,6-sialyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059:SF1">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 23" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="206"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="431" mass="49635" checksum="D7DAB8FF1AA71C20" modified="2016-10-05" version="1">MNIERQRLFNKTPSNPQRNNGQDIKYQQTFYSEKNSTNSISSSRENDNGHKNRRSIVAMKNKAKLYQSSGTQVRPSTNVVVKSGSPRFPNIHKPILEFDSEKYVCDDYLTTDCETRTAEFRTLLLKEFHRVLMSESKVFTSGLNSQNQYDVHYERGNWKEPTRMDILCALAGVSVRTVTAKDEPFKRLNYNIPKEPLQQHRTFNTCAVVTNAGSLLGSRLGDFIDSHDMVLRFNNAPTENYTEDVGSKTTFRVLNSQVVTKPEFQFLEDPLYKNVSILIWDPANYSSTLDEWYHHSDFPLFPVYKRLLEIRPKADVHLLHPNVLWSLWAVLQNSSSYRLRRNPPSSGFIGVWFAMHRCGRVRVFEYVPSSRATRRCHYYAPRADSACTLGAWHPLAQEKALAEAIRDNSDIDVFQRGFIDIPGVNTISCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RAQ1</accession>
    <name>A0A194RAQ1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur clusters transporter ABCB7, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-binding cassette sub-family B member 7, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_06850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167627"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67029"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460416">
        <property type="protein sequence ID" value="KPJ14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RAQ1"/>
    <dbReference type="FunCoup" id="A0A194RAQ1">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RAQ1"/>
    <dbReference type="KEGG" id="pmac:106710948"/>
    <dbReference type="InParanoid" id="A0A194RAQ1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="142"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="477"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="717" mass="78504" checksum="74103F7EB19AD50E" modified="2016-10-05" version="1">MAAALLSNRKFDKFIHNHIKLNRSFCNIKSVVLNKPQFSIICKQCASASSYRYYSSSSPNNAAGSDTAKNVLAAVLANKPKTGKIPVGIQKRDCFHPGASVLSREDINLGDAKPVSGMDMIRGMMEYVWPRDNAMIRNRVMLSLSLLFGAKVMNVSVPFLFKYAVDEVNHVATTPAGDALLGMATVPQALGTTAFSLLVGYGIARATAAGFNELRNAVFAKVAQHSIRRLACNVFTHLHNLDLSFHLGRQTGALSKTIDRGSRAINFVLSAMVFNVVPTIFELALVSSILGLKGGFAFAGVAFSCVGVYALFTLAVTQWRTKFRVHMNRAENEAGNKAVDSLINYETVKYFNNEKYELEKYDQSLKKYEDASLKTASSLAALNFGQHAIFSGGLSIIMIMAAKEIAQGNMTVGDLVMVNGLLFQLSIPLGFLGSVYREVRQALIDMQTMFTLMTVQSRIKEKAKAPLLNVTAQTASIEFKDVSFKYINGKPIFNNLSFSIPPGKKIGIVGGSGSGKSTMVRLLFRFFEPQSGQISIAGQNIKDLDLTSLRRAIAIVPQDCVLFHDTIFHNLHYGDLSRPHQDVYTASNMAELHDSVVTWPKGYETQVGERGLKLSGGEKQRVAIARAILKDSPIIVFDEATSSLDSITESAILQALKAATVGRTSICIAHRLSTVADADEILVLENGSITDRGTHADLLARQNSLYRRLWDKQNRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBK0</accession>
    <name>A0A194RBK0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sodium/potassium-transporting ATPase subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">RR48_06774</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Ya'a_city_454_Pm</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RBK0"/>
    <dbReference type="FunCoup" id="A0A194RBK0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RBK0"/>
    <dbReference type="KEGG" id="pmac:106712762"/>
    <dbReference type="InParanoid" id="A0A194RBK0"/>
    <dbReference type="OMA" id="WEGFRVF"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="48"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KPJ13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="323" mass="36468" checksum="30CC6E872FAF5A5A" modified="2016-10-05" version="1">MADKNKVAEQYYAPPPDLGKWEAFRIFLWNSETGQVLGRTGSSWAKILLFYLIFYAILVGFFAAMLAIFYQTLDSKMPKWQMDGSLIGSNPGLGFRPMPDSANVESTLIYYRANDKGSVLKWATVIDEFLEQYRKKGSGGGEASGAENRVPCSPSTGALGEKQVCDVPVDKFNPCTSANQYNYEQAGPCVFLKLNKIFNWTPQPYNTTEDLPTNMPEDLKHHIKTMEGKPDANMVWVSCQGENPADVENIGPIQYIPGRGFPSYYYPFTNKEGYLSPLVAVLFEKPRTGVLINIECKAWAKNIFYDRYERRGSVHFELMVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBT3</accession>
    <name>A0A194RBT3_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RR48_09325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Ya'a_city_454_Pm</strain>
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        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265081" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="64" mass="6988" checksum="54499FE78491B910" modified="2016-10-05" version="1">MLKVVLLLLVVVYTCQAEVYGQVNFLEMPKNSAVDGPMGFRRVGTGNDGPEDVPKAIPFFKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RBZ9</accession>
    <name>A0A194RBZ9_PAPMA</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="7" type="ORF">RR48_09154</name>
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        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KPJ15127.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11877">
        <property type="entry name" value="SH3_PIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
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    </dbReference>
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        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="82"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="357"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1376"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1423"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1495" mass="167382" checksum="747EB6A55548F55D" modified="2016-10-05" version="1">MMSTENCLVKAIYSFKGKNNDELCFKKGDIITVTQREEGGWWEGTLGETTGWFPSNYVTEHKDPSGSLTTSPIRAASEIQAFRNVVLKDIIDSEKAHVAEMQGLVTNFLQPLENSEMLTKDEFKQLTGNINEVLQTHEQFLVLLEECATKTGPDQRVGGLFLQWAPKIKAVHQTYCAGHPKAVCILDKYKLTKDEFKQLTGNINEVLQTHEQFLVLLEECATKTGPDQRVGGLFLQWAPKIKAVHQTYCAGHPKAVCILDKYKEGLNTWMENAGAVCPGVLVLTAGLSKPFRRLGKYPAMLQELARHVHEAHPDRGDTHRASVVYKDIASGCAALRRQKELELQVVTGEVRGWPGGELTSLGDVLHMGSVAVGPSHQDRYLVLFPSALLLLSVSKRVSAFVYEGCLPLTGITVCKLDDTDTRKNAFEISGPMIDTIVAVCQTRAEADNWVSLLQKHSNTSSPSHEPGQPQSLPQLTRSPSEGALSCINTSRRSLYHVTLPPPSYPSASPYYSLTKYFARLVKKKVITRQMLRKLLHERPWAKAFELTGLPVRRRHKNHIRLRIEDDGTIGTETDCSDSDRNSDDSDREESDTTETQSTSSCTDAEFNDSSKIMRQNALESSSPRTISSSCGSCGSNFGYVRYFDTSTDMHLDVTQPFVKGDCTKNIFLPLPSTGLQIPPGFENVPHSALQHSHSNENSSFDVRSYMACEDLVNMDQNRQIETMTNNESDFIPTRRSFPNRSVKNENVQKLWKSAEERYSRDNIDDGSAMANLLQELEPPSPKNDRLSPVGSIIIDPPPMFRNNDEDLKVLSVNLNTNVPFRKHSLNSDKKIRRSVSRSMVETENVKKTDPHMQRMSSQSETRKVVKKCECCNRSLCPSPRSSDSGVAGSCNLASPELNMPEYTSAGGTSNDSDSQSKTNVPQSFHANRRKLTLSEIEAAAFEDQCRCTSPFGSTARTSCVTSVTSETSLDVMDSSNTFVTSTFAGNPPVSTSQIKRTSIRRNIERYVPEIKIKPDVPPRIYRKPSTHIEMPKNVRQPVPCQWSTLNITERTKPSLHYHMRIYREKPGENKQQTSMRPSRENILRKCDVFNKENQSKDDNTRKTRSRSEDLLKSQKVLSEAQTGFVVYRSDLYAHWWMKAKLPITVVTDSGKDYFFMAMSDSSNELASALSSHKRSHSFNNHQSYTQHSQQTQKSKHKNQSARWLLNSCDSLDQSPAKSNKAPIGKKYSSIDFIDTTEACHLNKGWSITCLRPAPPLRPQSFSAGSEENIGPTHPYAPHQRKSNSYEEDALILKVIEAYCTSARCRNAVSSVDCGHFSLGKVQYHALATNSPQHNYTKQPVAQRSATPDYIGCSKASKVKRNKSSSAADAYLYRAPDTLHTPHTPHTPHTPHTPHTPHSPHTRRLLADRKLQMNRSNPNLWECSEERDRRQRLHGGRERRSGSHPSLAPPLRSHVYANAPCPAPGPAHATTSRSARSSTWCCGTFVKQLTKSHHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RC29</accession>
    <name>A0A194RC29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase and actin regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RC29"/>
    <dbReference type="STRING" id="76193.A0A194RC29"/>
    <dbReference type="InParanoid" id="A0A194RC29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="510" mass="56650" checksum="988BC44E53CFD99B" modified="2016-10-05" version="1">MQLLSVPLSPVPKIALMKSQPKKDKLENGGELVRPERPNSLTAGKLPRRICYQGDVSGYGGGGGVGGGGVGMEGDNSQLMLSDLPEPPIAVSEIGPIPPPPMFSSPSPTRHHHHHQHQHALSHHPLSDSEEEDDVEEEEGESLGADTSRVEEIPPKEPLFNAVPLKSALKKRPAPAASPQGTPQATPLAPRQDHHHASFNTRPVRVGNAAENKENARPWEGEYRDEYSSESERVAAKLARKESLNIKLALRPDRQELINSSSRKESLNIKLALRPDRQELINRNILVVQSEHERQESWEAIGARLIRRLSMRPTAEELVERNILKSQSPAEEKKQKEEKKRYLLRKLSFRPTVDELKEKKIIRFSDYIEVTQAHDYDRRADKPWTRLTPRDKAAIRRELNEFKSSEMAVHEDSKHLTSSGFEAGDLVDVEFSTADGAGAGLSSAPPSVQPRREQLVNHLSRSELRCLLPCVGASRNLGAHSPANQRARVYCACGSRSAHHVYMPHDSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCG8</accession>
    <name>A0A194RCG8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase mph1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_09467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCG8"/>
    <dbReference type="STRING" id="76193.A0A194RCG8"/>
    <dbReference type="InParanoid" id="A0A194RCG8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="358"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="526"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ15538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="838" mass="91293" checksum="B25D5BC87701933D" modified="2016-10-05" version="1">MTENTESSINSIKLAPMPMSALIANLWPLQTQDFTPDSSFSSCDSDDSDCETIATKSPNVPKYTTPTTKLKPTNNYTSDKKLRSTNKENTFENWLKSNKTYPNKENRIIQSVNENAKLYQGPSKETAKRSALIPQQTNIQTQEKIGTAIKKTPEILKQQQQQKLKSATPKIKSGIRHFTPGSSRKSQSKTLIQNVIQNKKDKVRCELFSSDQNKDEVQTKPSQRAAHLFATPAPAPAAPQTPAAVSAPSSVVISTPVVTSVPVSTAVSSVVSVPGSAAVSIPVLGSLPNPVSAPVSTPISASVSKQISVPIPAPVPETPLNRTLMPVACVPTPSYPEGIKAYNTKVTFNTIQVKDKKYLLLKKLGVGGSSEVYKVVELGTTGEYAMKTVYLGSDQDLAKGYVNEVRLLRELQDSVRVIRLYDYEYDRSNQVLRMILEAGETDLAALLRDRGAALPPALLLHYWEEMLNAVLFIHEQGVIHADLKPANFVLVSGRLKLIDFGIASAISSDATSVVRSQAAGTYSYISPEALMGGAGGYGCADDASAAPIKVVELGTTGEYAMKTVYLGSDQDLAQGYVNEVRLLRELQDSVRVIRLYDYEYNRSNQVLRMILEAGESDLAALLRDRGAALSPALLLHYWEEMLNAVLFIHEQGVIHADLKPANFVLVSGRLKLIDFGIASAISSDATSVVRSQAAGTYSYISPEALMGGAGGYGCADDASAAPIKISFKSDVWSLGCILYSMVYGRTPFSHIPNLAKLAAILDPNHRIDYPPADHLPPTLITSLKWCLTYNARERPSVQQLLSFRHMAGARRPLPAPLIQKLRPHLTQDELKLLQRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCK0</accession>
    <name>A0A194RCK0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RCK0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147471" checksum="1F7E865EB970FEC0" modified="2016-10-05" version="1">MENTTSKHRTPSQCREWERLRRNRFNEAISKLGEIVKDILKDKPQFEASSNVQYPKIEIVQKAILCLTTCVQEKTQLKAEILALQVKLEAEKNVKPDKKDASIQVSAVMCKKNKNGKFVKLVMLQKSKKKNLKEKPSVTQNEAIKQNIEGKPLTENKIPNKNMQTLPKLLPLTSTNNKKGIENTIVMLPSAPYISFPQRPLLFPAVPPTIVFLDSNLQPINKPATIPIINRNNADMTKTTMVNVLPISAYSHPMSATRTKKNNVKPKQNVKRKHVKKGDKQTAEVSHESSVTKDTKTIPNENINSTKEENVTEKIMKISNTNDCNKEQNEDKENNICVKNSSDSTFNDKAQEKSENVMKSPENSEPNTTCSSTSNADLTISASIAQKPTEVLNNESREINLEGSSKPEKICPEKELLLVEKDKVNKLPNILDTALCDNVVDGGNARLELAEEFLAASPTAAFLMSFPLVSGNRADSPAEDHQNIQASLKENHQRRNEVPSQAPYFPKPHDVKGKMTKTDQNITEKQTEQQKFISNTNISKEIEPKVSTLITNSSNDNPFLHLSMPSLAPTSCPLTDSTFSLDFDCTVSKANHPVSVASSNNFFYKSDALSSTKTSIYSTSNISSGHEFNSLGLYPCAMEKFSTKNKSDFSNMEENLMKIGPSRLTYDIDLGWSHKGFDFVTCTTTSTTFNKDNILTSAPSQYSTAYNPFNPDFHVPLVTNSSKKDMPCKAITSFPEAITSFYSQPTNLWSEDMTFYTSNNFSKNFTPKPQNFVSMDHNPTNVALKTSAVKQYETKLTPDTAPNQLVKPLIEGPPIISDKYTKKSPSKMHINWMTSEIRPMQNNCNPSQANVKENHKPLYPQNIPQKKQDHNEGNYFPINMQNFPSQVTQEEFQVWPTARPVGTTEISIEPPPINLPTLVGDLALGPHDKKKNEAINRVLPQTDLQNCNNFFSVTQLMNRSSDVMPPRYQGANMDTHKTNPSKQNVPNVSNDTHRKGSRLETHLAQPCHVFESKPVNYETMGHFTQNKQKNNKSDKSAKNTKTSYSAEALIRGGPCNQKAQDTISKFLLPPQKYNEFNVTQESGVAQVSHFPPLLEYPDNSYAGQQFSGTTLYNSTTNTISNSFYSNFMPGSSNLMTGNYTSGHFQSDFIDYNQPAECNYTNYKYDDLKMKANTTLQDKPLPTQYKGSRRESTTKHKLECSKKESSKKCNSKRAKLTNEVEEWNDSAHMLWQSKAPTRRHPNISEDYSFPNYVGNQISASSQYQPELFNTHLMPSNMQSVGHNIDRSLTTFPPTSRANFNLSTIFPEITMKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDF2</accession>
    <name>A0A194RDF2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">nicotinamidase</fullName>
            <ecNumber evidence="7">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_09423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDF2"/>
    <dbReference type="FunCoup" id="A0A194RDF2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDF2"/>
    <dbReference type="InParanoid" id="A0A194RDF2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="395" mass="44480" checksum="1F32682A7566DC2F" modified="2016-10-05" version="1">MLVCLINERCESRPLISIKPTMSDVDNGSPVDEVCLLDMDACYETFDKDGDGQLNFDEFRLICKALFRNDKGHIYPLPEDRARHVFQIFDKNDDGFIDKEEFTFCWNHWIKVIVRPVSAFLVVDVQNDFISGTLNISKCNAQQDGSELAISGSWQLSPPRLAPLTPQTTLAVRVVEPINRLLESVPFECVFYSLDWHPPDHVSFIDNVHMRELHVSSPVSADKAQAYDTVVFAGPPPMKQRLWPRHCVQDSWGAELHRDLKVLDGAVKVYKGTNSEVDSYSVFWDNKKLTDTNLSMQLRARGVTDIYICGLAYDVCVGATIADALAIGYRAVLVDDASRGVDLADIEKTKATILNNHGVIVDSDQVLAMVEGRDRRPELGYKLAMELKHAMEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE44</accession>
    <name>A0A194RE44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE44"/>
    <dbReference type="STRING" id="76193.A0A194RE44"/>
    <dbReference type="InParanoid" id="A0A194RE44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="179" mass="20299" checksum="30605FBA3D87D223" modified="2016-10-05" version="1">MECSKDMGLQKRHSQFSDTKYKWRTVLVFVMFGVCVSNGQAVWSETDPYLLNKSLGLTELPGGVLAGGRTHWKLNGSPYLLRDDLLVEREAELVIEPGVELKFSPMVGITVRGKLVAVVSYISLEKKLMISVNLVQWQDRNLVALWVVGSNRHVSCNWGHFRDWLSSSQKCNQKVILNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE52</accession>
    <name>A0A194RE52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE52"/>
    <dbReference type="InParanoid" id="A0A194RE52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="51" mass="5624" checksum="DBF5B4CC127D35D8" modified="2016-10-05" version="1">MVSHSEKVSVLLRTGDRRGDVSLIEFRFRDAAGAAARLQPKYAALKLLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE87</accession>
    <name>A0A194RE87_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE87"/>
    <dbReference type="InParanoid" id="A0A194RE87"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="219" mass="24915" checksum="9BE24FDF389D6ED0" modified="2016-10-05" version="1">MTMDVGMYGEQQGCGEYYPPPCQYDCHEGYYDQQQYYEPALAAPLDTPPVISTDAGLCYTNLDYGELQHAYPAPTHAPHAPHTPHTPHAAHTPHMPLAHREEHKLDGHCLESKYNMHFVDESVQYSAHAGSPLPCGDFDPYQPKEEFLGLREGFPRDADLHALAPHTHVQHAQHAQHAQHAAHAVPTYKWMQVKRNVPKPTGEYFFKMYHSSYKKTFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGJ4</accession>
    <name>A0A194RGJ4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_13794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGJ4"/>
    <dbReference type="STRING" id="76193.A0A194RGJ4"/>
    <dbReference type="KEGG" id="pmac:106708806"/>
    <dbReference type="InParanoid" id="A0A194RGJ4"/>
    <dbReference type="OrthoDB" id="6850041at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="205" mass="23770" checksum="997D691F701C7A6D" modified="2016-10-05" version="1">MHNILLKSLVLRRPVFTHNFRWKAYYQHKYDPKVEDVINKQIQAEQQAAQDYLAIATMFLHPCMSRPGAGGYFMKMYNEELEHMQKLIEYQLIRGGAIVISGLKAPTMDNKLTLQSAFKKGLSMEKSVTELLENVVAVAEKVDDYQCADFITSVYLAEQMSSINELSHHVTNMDRLCGDEHAVYQYDQHLLKSYPNPFKFKMPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGK5</accession>
    <name>A0A194RGK5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGK5"/>
    <dbReference type="InParanoid" id="A0A194RGK5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="155" mass="16964" checksum="C560D51B825D521C" modified="2016-10-05" version="1">MFGAIAMTTDEGKCAVRASYGCRRFVDYIQLVLSSLSDLYADDLLDADKTFQGKTTADPNVSISTMSEDVPTLTLATIMGVTVVIIIAIAVVFVLGVLIDCRQQRILDKKIGEVRRRKNLRRVKSHPQADVVCIVNEIEGPGLSVPPMEALRNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RH99</accession>
    <name>A0A194RH99_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_10294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RH99"/>
    <dbReference type="FunCoup" id="A0A194RH99">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106708998"/>
    <dbReference type="InParanoid" id="A0A194RH99"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="340" mass="37793" checksum="82A9458A4840AB22" modified="2016-10-05" version="1">MSHKPTPYSPNFPPGQGYEPPAEGGKHNESYPMNPHGDYQGPTHHQMPQPGPTLPPGAQPLPGMHHGFQPGFQPGFQPGFQTGFAPGYPHPQSGYPAPVMQQPAPQGPPGGWMTIPRGLSNCPPGLEYLSMIDQLLVHQKIELMEAFVGFETNNKYTVKNHLGQKVYYALEDNDCCTRNCCGPMRPFEMKIMDNFSNEVIHLHRPLACDSCFCPCWLQSMEVTAPPGTVIGSIEQEWSICKPCYVIKNASGDVVLRIKGPCCTFSICGEVEFNVYSRDGDTKVGKITKQWSGLAREVFTDSDYFGITFPMDLDVRIKAVLLGACFLIDFMFFEKTRNHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHA8</accession>
    <name>A0A194RHA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHA8"/>
    <dbReference type="STRING" id="76193.A0A194RHA8"/>
    <dbReference type="InParanoid" id="A0A194RHA8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="630" mass="70943" checksum="1E074FFCEE1A7DDC" modified="2016-10-05" version="1">MRLFSTSLLRRFRLDGIEQASNPIETEFLLPYRASAFQFHKYKLLMDLFLPSQNLLETDESLTLVEKCLLHKLLSSTVQPWQRGDENLMCPLSAEQMENMSTNSSGRIHSRCPIEDGVIQTDWGPVAVGTIIAAIAASLESQRVSLTDIFSANIYKSEVSQPMIDRALADWEKQIEKPYENNNNANFEIKTPATDQLNISNILVATVVGDLAEVVVNQGPRVGASAQLMTVGSNNRWNDTLLPRDFYLLPQNRNDWQFTDAEILAGVDGLILASYMPSWIELRRSLRLSQVLDSYYSNEGVSFEPAVRACNRLALYNSVLNSTLLTSETLRFAQVLSLTQNTVYIPLEEMQRMSEAAVTAFIEYVPSVLRKYQRNCVSIDSVPVVDLIVATDSSWRGYDVEQFLSWVGGALELDAERSTLGVVHGNTGRWVAPPAHNITDLFTHIANYTDPWPNRLNLPNVLTTVNQHLRNKTLQDINSKASAGRSTVILIMSPTDQPSGNEIETSRTIMHSIRSSFFDAYFAYAAQDLTNFQNINNEYLDYSEIFITLPSTCVQEVATAIDTFMIKNDIPKRIVGAACPSNGTTFYQIEYEDSVLSKKKRGYRIHPFYLRQQPLIRVQVTAPSMIVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIJ9</accession>
    <name>A0A194RIJ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance protein-like 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_08573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RIJ9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="111"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="524"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="869"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1440" mass="156023" checksum="663C627BA83D5302" modified="2016-10-05" version="1">MNILYWMNLVSPTGGFPALAPALDFPRWRYATWGERCATLCGAVLGWLCAGGLVLAVLAYGEITALFVQRHKAEESSATSYLMYLFGGGRHLPNGDRPSHMDALVEDSIAFAWASVAIMVAQVVAAAIAVTLCNFAASRMIARLRWKLLQSVLSQEIAFFDTNTTMNFAASLTEYDFYTLWYTTIKLARRETEKLRQGVGEQVAMTSYLAGTVALSCALALAYGWQLTLAALAVVPIAIIFAAIVAKNQTQWSGEEVSRYGAAGRLVEQALAAVRTVRAYGGENLEVERYSEALQGASIASRRRVAWAGAGAGVGWLLTYSLNAIVFAYGAALVARDMPLPPPERVYHPGVMVTVLFCTFMAAQNIAMCQPHLEMFSAARGAAKSLFKLLERRSKVDALRNSGTKPDSFKGDIVFDNLYFNYPSRPDVKVLRGLSLRINAGETVALVGGSGCGKSTLLQLLQRAYEPDSGSVTVDGHALNDLHLHNYRRSIGAAKSLFKLLERRSKVDALRNSGTKPDSFKGDIVFDNLYFNYPSRPDVKVLRGLSLRINAGETVALVGGSGCGKSTLLQLLQRAYEPDSGSVTVDGHALNDLHLHNYRRSIGVVGQEPVLFSGTIRDNITLGMENVSEADLIAAAKTAHAHSFITKLANGYDTVLGERGAQLSGGQKQRVAIARALLRRPAILLLDEPTSALDPAAERLVQAALDAASVGRTTLVVSHRLSTIVNASRIVYVEQGAVLEQGTHDELLAKSGAYWRLVNDDLTHRSIEKALAESTAEGEDDDVVVERRPQPVRRNSSICSTRSRKGSMVREGFMRSSLRLTTPPTALEMATETEIDDELEGDESKQEKVPAVSNWQLLKLNGAEWPLLLGGGLASLAIGATMPVFAYLFSKLYGMFSLSNPDEILAKSHMYAGMFAGVAALSGLVTFLQAWLLGRAGAQLTDRLRVMTFRNFLVQEQGWFDMPTNSVGSLCARLASDCAAVQGATGTRLGTMLQGTSTMVLGVGLALAYSWKMTLVSLLSVPCVIGCIWLEGTVTKRAEERELKSLQRAARLATEAVLNVRTVQSLGVELAILDRYAEALRESDAHARGARWVRGPVYGLCLCAPTLGYAVSLAYGGYLIAREDLPYEYAILVSEALIYGAWMLAEALSFAPNFAAARRAAARVVSALQRTPQVITEPTAVEHPDWSATGEINFSNIKFRYPTRPQVEVLRGLSVSLQAGRTLALVGPSGCGKSTLLQLLMRSYDPDSGNVTVDGRDVKRDLTLRQLRAQLGLVQQEPALFERSVRDNIAYGDAAREVPLDEVIDAAKQANVHDFIASLPLGYDTVLEAGSAALSGGQKQRVAIARALLRRPRVLLLDEATSALDAASEKAVQAALEAASRGRTTIIIAHRLATVRHAHTICLIDKGVVAESGSHEELVRKRGRYWELLQQQAPVEAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIP3</accession>
    <name>A0A194RIP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methyltransferase-like protein 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460118">
        <property type="protein sequence ID" value="KPJ17698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIP3"/>
    <dbReference type="FunCoup" id="A0A194RIP3">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIP3"/>
    <dbReference type="InParanoid" id="A0A194RIP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ17698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="305" mass="34653" checksum="33B24ECF8AD74E7B" modified="2016-10-05" version="1">MTFGAGGHSRQLLTSADCKLITLDRDPLAYEKAKELAKEFPNRVIPLLGRFSELPALLKERNIKQSSIDGILFDFGCSSMQLDNGERGFSVSKNGYLDMRMDAGRDPNQITAREVLATANEQELYKIFKVYGEEKKAAKIAQTIIQARYMIKNIETTRELVDIVDSCCPNEFRLDKLQRPQSNATKVFQALRIFVNNELNEINYGMVLSKYYLKLNGRLVTICFHSLEDTIVKRHIAGNTVNDVANPVPLRYLSPTLVQDQDTINQFLDSPWKAINKHVEVPSDDEVERNPRSRSARLRAAIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIT5</accession>
    <name>A0A194RIT5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 4-coumarate--CoA ligase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_08741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460154">
        <property type="protein sequence ID" value="KPJ17250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIT5"/>
    <dbReference type="FunCoup" id="A0A194RIT5">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIT5"/>
    <dbReference type="KEGG" id="pmac:106708401"/>
    <dbReference type="InParanoid" id="A0A194RIT5"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="57"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="479"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ17250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="565" mass="63092" checksum="2CD16ECEB892C020" modified="2016-10-05" version="1">MFRTQLITKTFKNEYRNLLGVLIKKKHVWTSDKIAKSPFKDIEIPNISVAEHLVNNLEKWATKTAAVCGITGRNYTYEQIHMQSQRLGANLRKKLKIENGDTIGVLLPNMPEYLTTLIGSLNAGGIISTMNPNYTAYEIQRQLTMSDTKLIFTVRETVDTVKEALKLSQRNIPIIVINLDGKLPEGTISFKELVEDSHVDVSILKEVNSKGEDLAFLPYSSGTTGLPKGVELTNTNIVANLIQQDTECRQYEYTTESHQDSVLVSLPMFHCYGLTVVTLHKFSVGLKLVTVPQFRPETFVNILSNFNLNLFYLSPPTVLFMGSYPQVLPKYLEHLRCITCGAAPLPVADIEQFLSKLKPSAHFVQAYGLTETSPLATCSPIGQKDYTKVGFALPNSYLRIIDGNNNNLGPNEVGELVIKGPNIMKGYKNNPEANKQVFLEDGWLRTGDLAKVDEFGAVTIADRLKELIKVNAYQVPPAELESVCKEHPAVFDAAVVPIPDEKTGEKPKAFIVVKDSAKVNEEDIMSFVAKRVAPYKRLKEVTFINEIPKNPSGKILRRVLVEKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKY2</accession>
    <name>A0A194RKY2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKY2"/>
    <dbReference type="InParanoid" id="A0A194RKY2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="76" mass="8276" checksum="94A77BC527A2833D" modified="2016-10-05" version="1">MNVKFVVYFECAARICQGQRGTARDSSGQLGRRGTGRARPSRGAYSYTQTINSDDSAFGAETLAKRVLASEPTDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL31</accession>
    <name>A0A194RL31_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL31"/>
    <dbReference type="SMR" id="A0A194RL31"/>
    <dbReference type="FunCoup" id="A0A194RL31">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL31"/>
    <dbReference type="InParanoid" id="A0A194RL31"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="37"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="427"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="834" mass="90786" checksum="C70771C07FEE8B21" modified="2016-10-05" version="1">METYRNQPTIEFDPMCDKENPQKISFEDVSAAAFRIQSGIVKTPCVKSHMSSIYGMEIYLKNDFLQHTGSFKERGARNALLLLSKEAKERGVISASLGNHSQGLSYHANLLQVPTTVVMPNVAPIMKIEKCRSYGANVIIHGNDMKEAKYHAMTLAKERGLTYINGYDHPHIMSGQGTVGLEIIEQVPEVGAVLVPVGGGGLMAGVATAIKHLKPHVLIYGVETEKCPSMKMAMKQDEPVSVDIRSTLADGLAVPTVGYNAYRTAKPLIDKLITVNEDWIARAILRLVEQEKYVVEGGGAVGVAAIMAGLVPELANKKVVCILSGGNIDTTILGRCLERGLAAERRLVKFKVTVSDRPGGIAELCKLIASIGVSIKDIMQERAWVFGDIFSVRDPEFDPYCDPANPRKIKYDDVLAASRRCVGCVVRTPCVKGHMSETLGMELYFKQEFLQYTGSFKERGVCNTLLLLSEEQKRNGVITASTGNHGMALSYHSARLGIPCVVVMPVRTPLTKISKCTSFGVKPLLHGLSIADAKLYAMTMSKEKKMVYVNGYDHPNVIEGQGTTGIEIMEQVPDVDAIVIPVGGGSLISGVGVCAKHIKPSIEIYGVETDKTCSMVESFRKNERVFYPIDTTIADGLGVNKVGVNTFFTLKGIVDKMVVVKEDWVARAVMHIVEQERFVVEGAGATGAAALMAGLFPNLKGKKVVCILTGGNIDTTILARALERGMAAEGRLVKFKVTVSDRPGGMAELCSLMATCGVTLRDCIPERAWVKGDVYSVELKIIAETRGWDHTKELMELVKKSYKDCFFQEIGGGSEKPTVRRGPCLAPNPICMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL70</accession>
    <name>A0A194RL70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein Fer3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_11913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL70"/>
    <dbReference type="FunCoup" id="A0A194RL70">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RL70"/>
    <dbReference type="InParanoid" id="A0A194RL70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11415">
        <property type="entry name" value="bHLH_TS_FERD3L_NATO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF63">
        <property type="entry name" value="FER3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ18065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="185" mass="20692" checksum="E608FEEBC560482E" modified="2016-10-05" version="1">MVLRLLDDSYQLRPPHKLSALNWYGFSKNLTTCGSEVSPYGPLWEAPPASVPYPDILAFPPADLVWSAGGCGTRGAARATAGGKKPRRRVASVAQRRAANIRERRRMFNLNEAFDKLRRKVPTFAYEKRLSRIETLRLAITYIGFMCELLHGSPSPAPAPHHAHAHAHALHPHRHVFEAEVPWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL85</accession>
    <name>A0A194RL85_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptotagmin-16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL85"/>
    <dbReference type="STRING" id="76193.A0A194RL85"/>
    <dbReference type="KEGG" id="pmac:106721556"/>
    <dbReference type="InParanoid" id="A0A194RL85"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08408">
        <property type="entry name" value="C2B_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000062">
        <property type="entry name" value="synaptotagmin-14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="187"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="386"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ18080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="526" mass="57845" checksum="87072DFA4EF8E334" modified="2016-10-05" version="1">MVANIGGINPTNVEATAYISAVAGFAAVVLVVLLFLGRRWCYATVFTRKCCDEILAVNAHISDPCSTLDDAKFDALSKPNHYPERIFAFETSDSDEELRLRIQQDKEEVECHYEEKNENVSAPVKVEVQLVETALRETRIDEVVPKKAEYIHTLEAQSSVDSDVLAHNDTSLLCGESGGGGGGGGEGRGAVELTLLYDAPVRSMTVHVLQARGLPQRAPPQLLQSQARIVLLPLKKQKFKSKIRNGENPQYMESFVLHKINPEDVHGLGLRIRIYGCERMRRHRLLGEAAVSFAALNLELENNLWLQLAPRHHQPVMQLPKLELDGSVTGMLASPSSLSAGVSGLSGVSGLSGVSGLSGGNGFVSGGEACSLARSDSASSCCSARSAPELLLGLQYSPTTGHLSVEIIKGTHFRKLSPHKAPDTYVKLCLISSLGMEMGRCKSTTRRAQSNPLYKELFIFQVALFQLTEVTLMVSVWWRRSVKRNEMVGWFSLGHSSSGRDEQRHWDDLCQRQGEQVQRWHVLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RMY5</accession>
    <name>A0A194RMY5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RMY5"/>
    <dbReference type="InParanoid" id="A0A194RMY5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="545" mass="61915" checksum="7E838B52E0B2FDD3" modified="2016-10-05" version="1">MAVFAAADQSPVLRTHLLSRDCTSIKQNKLIAGMSARSSLSSGSGRLPGATDIIDLDRYMRAAVRPGISPRHDRRERLVVDAGGFGRKAGRGPLASNASSSSATAGSNSETPHMKRFSHDSGLSDGSNPQHRHRSHRRVSGDVTTHRCRESARGRGSASSLLAFRTACERALREQQEQIARVAQLCERLGERRNERRNERHSERRNERRTERVKCVRPKPERPKGDRSKPDRSKPERLKPERSKSERPKPKRPIPECSTTSIESSNISSSSRSSRERHKDKHRTDECKTYKIIMNKLDELSRLFAARRPMAPLTLSTKPMTLYRDGFSSGSVSVSDKIVATEPDLHTCITSRQLSPTVQILLTPRPTERKVDLQIQTKATGTTPIPSGEQMRQKDRMLRGERRREVRPCENRRLAVTRAHFLEIAPLQEKRPNVATERVVQRDLNSDCNTTRNQLTSFDLDDPLSFYAQAKRLQALYAEPRRARSEDRELRNERTYDMRGFSVGGRFAERLGEESLCARCRVYWRAFRDCFTTQLFCRPGRACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN24</accession>
    <name>A0A194RN24_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_08587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RN24"/>
    <dbReference type="InParanoid" id="A0A194RN24"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="148" mass="16184" checksum="61A6323A3B085869" modified="2016-10-05" version="1">MPSAATVGKYAFIGSSRLECCFSALVGLASAAPWRCYRTRNGDTVCISNQREPCIPQPTICTPPLAPPCAGPAYVYTPQCIPPCPQPEPYIPPCPEPCPEPCPEPLPPNPCYYPYVPPCPEPCPEPEPTPCYYQRFQPCIEPCAMPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RN29</accession>
    <name>A0A194RN29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trypsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_12433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
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        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50494">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265318" evidence="9">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ18922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="28411" checksum="4BE7BAC9CF96D0E1" modified="2016-10-05" version="1">MKCTSVFVFILVLSNELESLSTATLIATDTSARIVNGFEVDITEVPYQAVLRRKVISGWAHLCGATVISTKTLVTAAHCTSSYEFEPPLLRAVVGTSYRLIGGKTYELSKVVVHELYSTTTLENDISLVITTKRMIFSASVQAAGIPNANFLLPVGSTALVSGYGNISSTGTSSSVLLAAQVKIVKQSTCARAYIRIADITQGMLCATADNPPRDACQGDSGGPLVVNNTLVGVVSWGEGCADMSYPGVYTRVSEYNSWINKYLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RNQ7</accession>
    <name>A0A194RNQ7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAG domain-containing protein Samui</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460124">
        <property type="protein sequence ID" value="KPJ17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RNQ7"/>
    <dbReference type="InParanoid" id="A0A194RNQ7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="386"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="701" mass="79150" checksum="FA4A99732263688F" modified="2016-10-05" version="1">MYDVVFQQRGFPFDEEEGSGAWSELAARHPDIAARLRQRPATWARKRRPSSQDATDDFEDFSGFDRFPFDDIPSEFREHFPSHWNRRFGSREEPPPPSPPQPQSPQQQSAATQTDCPPGSSAHPAHTTHIAQDDQHSHLPQYGLRNTVDLGQKSPADPSLVDEEDRTQRSMSAPPDNRNAGLNNANKMSGQNHQEQSHNPHPEQHSNVRHIPIFVEGRDEPVINKSVDHATHFGDTKPAYVPPPQPHIDRDQYFADDGPVNFHAPPNFSRAFGTPFNKGFRQGPQPFVQQKVYPQAAFARGASPQRSQSPKPQMPPEEHYVKVPVHHEQTAPRAETPSRPQQKQAPRQSTPPAQPHTQPPPHRHTPTPPPQPKPQPPPANDPKTQILAIQTDVLNLMSEVENFTGTKKDKKYIYLDEMLTRNLIKLDNIETEGKENIRQARKEAIRCIQKCIAVLEAKAEKGSKAAQQQDVEMENSESQNAAHDDKAVENGEVEMKDMSKEQSTAEAQMVDVNSEKPNEEIKQEEVKDQPKDEQPKDEKIQEDAKTEKASESAEVAQPQIADTRPEEQVKEKTPEIKPDEQKQNENIEKEKKSPKKGIKNVKKRDKSKDKKDATNDSIKDVNVEKKDNKPENKQEDDKKGSTEQKEIIEEKKDEKAGEEKKDVADANVEQKDNKLESMQVDGKGDKTEPQTMEVDNAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP43</accession>
    <name>A0A194RP43_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_06473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459875">
        <property type="protein sequence ID" value="KPJ19613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RP43"/>
    <dbReference type="FunCoup" id="A0A194RP43">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RP43"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942:SF1">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ19613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="298" mass="34337" checksum="45EFADC03DAA4607" modified="2016-10-05" version="1">MDWQLTCRVCLETGDMVSLFDWDENNEQLADKYLYCCGIEVTKKDILPTLICLNCVDRLTFAYQFKQQCIASTDTLKECLEEFMKSQAEVSEPKKEASETETITIKQENGLLLQYDLPVEHDPQAQWTRTLTKTPTTTVVTKSPGPKKRGRPRKYPNEQGQIDISPYTRKKHKDSDKEPQSLTSLLASGTLELKEEPLDDEEVFGGEHYDNSDPDFIPAEEVESEPETKKEAAPRRRGRPPKVHIEPVKEKTQDGEDVLLKETILAFSEPIPDHILNPKPKKRRSYIQKKKKYNYEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ33</accession>
    <name>A0A194RQ33_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_11141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ33"/>
    <dbReference type="STRING" id="76193.A0A194RQ33"/>
    <dbReference type="InParanoid" id="A0A194RQ33"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000001">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="55020" checksum="38AFC96575188BCD" modified="2016-10-05" version="1">MSGGHKHRYKNAGLSADELRRRREEEGVQLRKQKREQQLFKRRNDDINISTSDDITPEMVAALYSDNQQEQIVATQKFRKLLSREPNPPIDEVIHTGIVPKFVEFLTNSSNPTLQFEAAWALTNIASGTSEQTRVVVESGAVGALVALVGGGAGDDVREQAVWALGNVAGDSPRCRDAVLAAGILPPLIEILNKYTRLSMTRNAVWTLSNLCRGKNPPTNFEAVAPGIPVLARLLHHTDADVLSDACWALSYLSDGPNEKIQAVIDAGVCRRLVELLMHNKSTVVSAALRAVGNIVTGHDAQTQAVLNCNPLPSLHALLRSNTEALRKEACWTLSNITAGNAVQIQAVIDANIVPTLIEILRQAEFKTRKEAAWAITNATSGGTRDQIRYLVEQGCIPPLCDLLTLTDSKTVQVALNGLDNILKAGQQADQLNPYAALIEECFGLDKIEFLQSHENLDIYQKSFEIIENYFGSEGEDGRVAPVSSSGQYHFAGDQAVPMGGFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQM3</accession>
    <name>A0A194RQM3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">c-Myc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQM3"/>
    <dbReference type="STRING" id="76193.A0A194RQM3"/>
    <dbReference type="InParanoid" id="A0A194RQM3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="101" mass="11522" checksum="7C4A182E8D221150" modified="2016-10-05" version="1">MLPYFTDQYFYYPFLGLFAPIDSKREEFRRYLERAGVMDALTKVLVSLYEEPDKPEDALEYVRKHLGTDGGEDELEAARARIAELEAENALLKGETAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSE0</accession>
    <name>A0A194RSE0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vesicle-associated membrane protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_06131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459700">
        <property type="protein sequence ID" value="KPJ20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSE0"/>
    <dbReference type="FunCoup" id="A0A194RSE0">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSE0"/>
    <dbReference type="InParanoid" id="A0A194RSE0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="192" mass="21796" checksum="288D103ECD4E28FB" modified="2016-10-05" version="1">MPILFSVVARGTVVLAKYATCAGNFTEVTEQILTKIPPRDDKLTYSHGNYLFHYIAENKLVYFCITDDKFQRSRAFLFLNEIKRRFTSAFGDTAQTAIPYAMNGEFSRVLATEMTHYSESKDLDTISRVHGELDELKNIMSVSYRASARTLQRSLFWKNIKMYVILIFIVALAIYLIGAMACGGLAWRSCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RTC6</accession>
    <name>A0A194RTC6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Voltage-dependent calcium channel subunit alpha-2/delta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_10988</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ459896">
        <property type="protein sequence ID" value="KPJ19361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RTC6"/>
    <dbReference type="STRING" id="76193.A0A194RTC6"/>
    <dbReference type="InParanoid" id="A0A194RTC6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="331"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ19361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="868" mass="101295" checksum="238BBB8F26BED21F" modified="2016-10-05" version="1">MQQKNNRKDDIERKKDDLYPKSYLQKGLIDLNEICLEEHIGYIYKAENLDNIKKSLEQHQKELTVVKNKTKILAKEITNVVKVPLKSAVPVDNASKKPKMISVKQLQEWGKEISDKLLDHESQIVRRDLLLKGFTNLKSVRRNGTEIVNQAATVLTDLLSKRAKAAEAIMRKAEELSKKNVPPPPNYTYMQSTNLDQYKKEDTDWKEDRRNFTFPLNCRNLNKVNLYKSKHFDANVSLDTSSVHVAVEVFDCDPKILEHLHWSEGLISTFKENYARDATLDFQYICNAKGFLRHYPAALWDTMYKLKLDVEDIYDCRLRPWYVSASGAPRDILILLDASGSMTNSSNLLVAEQLTLALLSALTDDDQVNVLRFNVTVRSPITCFNDKLVSANHVNSAAIMAALAHFKMWNETWMGDVLEYSVRLLQKQRGTPDRPPSCQQAIVLLTDSLYDNYTQLLNHLDPEGRIRLFVMWLHDPYGLRDDTRSYGETLTCSRDGYYAELITAADVTEQVMRILRVLERPLVGQREQRLTVYSDVYANIEDPRRGEYYWKQKENAEQVYRYKLLRKNKAKLLNQSQLYKDHRRQLSLDEFGYYYEGEDLNYRLLITVSVPVFDHTTLENITIKLDEEKQRNSTRTYPVNRLLGVAGVDIPIDHLKLHVPYYKLGPAGSFILLDHRGSIVIHDNLRPVFDGDILKPGYRTVDFLDLEQSAADHLPREYPKDWIEFRKTLVIDQHEGNKTMYSKYIYDKGMRALLETQQYHWKRILEHYTAVVVLPNKEGRHALPNTKRFTQQLAKEAYKTLTETDFCTHPDWLYCQHVEPQFDSQKDEILYFMKRRKNDPNFQMQNLRHTFSPIPPTLQEKPYQCKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PAX5</accession>
    <name>A0A0N0PAX5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein transferase MAEA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Macrophage erythroblast attacher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ461188">
        <property type="protein sequence ID" value="KPJ07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PAX5"/>
    <dbReference type="FunCoup" id="A0A0N0PAX5">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PAX5"/>
    <dbReference type="InParanoid" id="A0A0N0PAX5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
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            <begin position="156"/>
            <end position="213"/>
        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ07321.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="407" mass="46489" checksum="28500D3EE9437417" modified="2015-12-09" version="1">MNEIKSLEHATLKVPYEVFNKKYRNAQRILDVEARHVGSTATELDTAAKRGDVTAGEIDTLLGGMVEKLTTMKRKASEAINEEVQAANVCKKRLDHLKEQAEALQDPAAAQTSLNQWRKVRLDRMLVDYFLRTGYYDSATKLADAKDLRDLTNVDIYQAAAEVERELTARRTARCLQWCADNKSKLRKLNSTMEFNIRIQEFIELVREERRLEAVRYAKKHFSTYEEGQLRDIQHCMGMLAFPKDTEVEPYRSLLSERRWVSLVAQFRGEHARLLHPARLPPLTVTLQLGLAALNTPYPFLYITWSMSGIHKVCFNESTKVSSCPACAPPLNALARTLPHAHCSHSRLLCRISNEPLNEHNPPMALPNGQVYGEKALKEMMKEHGSITCPKTKEVFCMKRVEKVYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB24</accession>
    <name>A0A0N0PB24_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">RR48_03498</name>
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    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
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    </reference>
    <dbReference type="EMBL" id="KQ461178">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="250" mass="26673" checksum="7760FA0F9A1E68C3" modified="2015-12-09" version="1">MSFKDKVVFISGASSGIGAASAIEFTKEGANVVINGRNETKLKNVYQQCEKHGKKPVIIKADISKDDEAKAAIEETIKQFGKLDILVNNAGFTKPGSILDGNLLKSYDEVMGTNVRAAMHLTALAAPHLIKAKGNIVNVSSISGSSMPVKPQLISYCVSKAAIDHFTRCAALELSEHGVRVNAVSPGPVLTDFRRNAGIGEDITERENLTALKRISESIEIADLILFLASDKAKGITGSNYVSDNGCLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBI0</accession>
    <name>A0A0N0PBI0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_02932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460938">
        <property type="protein sequence ID" value="KPJ10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A0N0PBI0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007999">
        <property type="entry name" value="DUF745"/>
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        <property type="entry name" value="HDC10475"/>
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    </dbReference>
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        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05335">
        <property type="entry name" value="DUF745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005857343" evidence="3">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="423" mass="44536" checksum="01A3970562E9EDF5" modified="2015-12-09" version="1">MKDFQAVLFCVGTLSIASSAPANRDSSAQASEYNYDYDNSAQSAKGQDPAEAASHYDAYISDVQAAAAGGTAKKGYSSGSGLRTIAVGSANQAKTALGNQVAAAYQAAYVAKNTLAQSAAQASATAQAALAGKQVILSGLEQQVRDAKVGLQGEEMQLQQAKRAAQAAAQAAQQAMHQVNVIQAALNAAQATSENANEAASQAAGELGAQTAMVGAARQRLHTLQEQLHGVRIDFEATQAAARKAQAAAQQAQANAAAAAAKAAAAGLASGKQQDASHEGTSHEEQRAAPEQGQDYYHQSDYQHQVEGVSSPSYESIRFVKRVLSISETSASLELQSEPASEKPIYLPLYEVKWHKNEPPQISNKAQKPLILDLSSFSKLKQINSNNSSYVIGLYSMGKLAKDEPAEAEEEEEEDEEEDCDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC13</accession>
    <name>A0A0N0PC13_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-binding protein-associated factor 172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_03076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460711">
        <property type="protein sequence ID" value="KPJ12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="2338"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PC13"/>
    <dbReference type="InParanoid" id="A0A0N0PC13"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mot1 central" evidence="5">
        <location>
            <begin position="684"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="SNF2 N-terminal" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1457" mass="160624" checksum="B7D1A3088D05EEDE" modified="2015-12-09" version="1">MSMGVDEHLGVPAARIMCQHIYGYTSKAVYNSINSEYLKIFIAVCEFPQSALSQYGWLQPTHCNIGLDRLFVLLEAGAGAATRRAAARQLGEVQKAHPEELHRLLGRLMKYLRSPAWETRIAAAQAVEAILSNVPEWHPTQCNVKKEENVETEEVCLLRCETFDIERVLENGAHLMGSEGREYDLEEVALSAGDMKERLAKQRQQLNARLGLDVAAKLGVDLTSVYTNEDLCPVKIQVKPEPPRRPVQELVPIATKPLSSREMNVAKRRARAAYGKQKSRDCDEGPSATSSQPTPSISLSLEPDRKKIKLEPVEDFIVDSESAVPDGLGVWGPSSRWPLEGWCAALQAQLFHGAWEARHGAASALRELLRARISASAARRPATTEQQMEDAHQEWLEDMALRLLCVLALDRFGDFVSDQVVAPVRETCAQTLGVALAQLREVRVRLVADALATLARQPQWEARHGALLAFKYLLAARQEVACAAGALEHLVAALEDVAEDVAGVAAGALAPAAAALAAARPHALPAVAARLWQLLRDQDDLAAPANAYMALLAALCALPQAAKHLHPIDLADVLPRLWPYLDHSTSSVRKATLQTLRTLTRPLVTTDDTKTNGNGDTTVVDVKVNGTDKVDSGLLTWTPELLQDAMRHVYQRVLFEHVHDIQEVALQVCFFLIAFLTDASILIFLVAACPMLATWMCLAMQPPRLPVDPSLLLYTPHKERRTRTTSLQSEQVPSEVRPTQKWFIGGSESQPAAARDRNVTRARCLAADILGYLSCYLVQPAPGIEYKSEDESPIHCYVKVMIVYLRSGSALQRLVAGLVVSAWARYTRKHNMYPPQVPHNGVNGDQSADSQERKDISLLAPELLTSTLHAALNQALYYDEVALNCNRILKEARDLLAMMKHYKLAVDGEEFNNILRLEQVVHMCNVTQPMVAGLKLKRVLQTLEERRASLLTAANQCAVDQATFNVSVQAALAGACANLHALPERLNPVVRPLMESIKKEASEELQAHSADTLAELLTQLVDRDPCPNNKVLVNLKAFLRCDPEFTPRISLEVVDEADSGSGDSGSETKREPQSTLTTLDKYNGILTLREQQRNAERSAPRRGRPPAAATLAAAAAGQDLTLDTLFPQEDEARKLLSIQRRGATLALTSLTRHFGDELPDKLPKLWEFITEPFAKVMTDAELVAQEPEAAEELISRLQVVEAVGARVGDALWPRLLGGTRACAALCRAHYTALRHMAARALAALAARDPHAVMHELVHELIAALDDVRNDRVRCGAAETLARLVDALQLNVVPYIVLLVVPILGRMSDHCEAVRTMSTRCFATLIQLMPLDGAVPEPAGLSAEMRARRQRDKDFLEQLFNPKSIKDYKIPVPVSAELRSYQQAGVNWLRFLYEYGLHGVLCDDMGLGKTIQSIVVVAGSHWERAHQRRDQLPSLVVCPPTLTGTVVHTVHFVHTLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCU6</accession>
    <name>A0A0N0PCU6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dystonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCU6"/>
    <dbReference type="STRING" id="76193.A0A0N0PCU6"/>
    <dbReference type="InParanoid" id="A0A0N0PCU6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21188">
        <property type="entry name" value="CH_PLEC-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ14032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="220" mass="25751" checksum="8CA457D6DDCF834B" modified="2015-12-09" version="1">MSTQAYYKERLGFDPQEAMQESLNGGASYYDGHQPKRHRGDHQPAEKHDQVYEENLSKFKDERDAIQKKTFTKWVNKHLKKVFTFTLLGQTYTRLHVCEIVNNQPCCPPQQVNRHVNDLFEDLRDGLNLISLLEVLSGEHLPRERGRMRFHMLQNVQMALDFLRYKKIKLVNIRAEDIVDGNPKLTLGLIWTIILHFQFTLPRNTSQPVNMAQATVLHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCY7</accession>
    <name>A0A0N0PCY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460396">
        <property type="protein sequence ID" value="KPJ15347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCY7"/>
    <dbReference type="InParanoid" id="A0A0N0PCY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="91" mass="10047" checksum="1CF99F7FAC430D01" modified="2015-12-09" version="1">MVVVEDEIKKKNRREKRRVRVPSDAECVSRWRVSMTPRALATRPAGCGRAVGQRDTGPQHVGGGTRAGYHANTRRANTLLHTNARPLSIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDA0</accession>
    <name>A0A0N0PDA0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgin subfamily A member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_05346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460317">
        <property type="protein sequence ID" value="KPJ16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDA0"/>
    <dbReference type="STRING" id="76193.A0A0N0PDA0"/>
    <dbReference type="KEGG" id="pmac:106709763"/>
    <dbReference type="InParanoid" id="A0A0N0PDA0"/>
    <dbReference type="OrthoDB" id="248903at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
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            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
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        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
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        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="550" mass="63056" checksum="5822554E464FD4D0" modified="2015-12-09" version="1">MSWFTELAGKAETLLNNIDEQTGAALRSHNAIKTKKYDNVSHTDNSRTQNKRPPLWAPKKIHFEKDRSPSPIKKRKVIPNAYIGDNKTQERVKMKSPVRTPNLVNSSPISPIFCGIENKPTDWGMDQYGVRRRRNTFSGDVSSLHMDNIYKLENLEVENAMLKNEINVMNRELSDLMDRLRKTEDDLNHYKSSPTNEGLDARNLKVDNEMLRSQLDQLKQKVVDLSTSDVKNKERNHELEAEAIELRSANRQLEEKYKILNEELNKKELAISKVENELRHAQGVISEQQSSLEKSTSECHRLEKDWESYKLRVKSMLFSKDEEIKKLREGSNLAEDTKQLIEQMKVLKEERDDFSEQISKVKEESERIKTSMGDMVSRNAAVERIVIALRDALKEERSARTRAEMESVSLEKELKAMHVEMGQTIAKLRASLQAKESELNKIRESQSAPTSDVSSLNVADYDVAQAAMDSERVQHLSQLLVQKQGKVEALLADNNTLRIQLDKLQTKYRTEVSGARAQLHSVVVQESRARYSPADTLAKMSLRIGVMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDH5</accession>
    <name>A0A0N0PDH5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Viral cathepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Neoptera</taxon>
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            <taxon>Lepidoptera</taxon>
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            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460328">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="115" mass="13614" checksum="BE4C89AFB1779D27" modified="2015-12-09" version="1">MSTSMSNKPIYDINNAEELFEKFIKDFDRQYKDEAEREKHYQAFIKSLKRINELNTKQDSATYDINKFADYTEEETKWMCGVIKPLDASNICCTHGPACPVQYLDHTEDKRKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE58</accession>
    <name>A0A0N0PE58_PAPMA</name>
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    </protein>
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        <name evidence="2" type="ORF">RR48_04742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="92" mass="10756" checksum="44760603489F1968" modified="2015-12-09" version="1">MSHLTPGPVKPLKPLPLGLWASPQTRLYMAFIGVMLYAYILFFIRTIFYKSQRLDQVGAMVMKTEQMIHRIHTTDFNMAINMERLDNGFLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PE64</accession>
    <name>A0A0N0PE64_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
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            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460044">
        <property type="protein sequence ID" value="KPJ18316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PE64"/>
    <dbReference type="InParanoid" id="A0A0N0PE64"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="61" mass="6974" checksum="6CD1D10EE20DD960" modified="2015-12-09" version="1" fragment="single">GAWDSVRKTCAFCSCPGCCACASREYELGEEGAGQRRRAMTDFDRRVRDDCKIMRIMYNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PEI2</accession>
    <name>A0A0N0PEI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_05493</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459941">
        <property type="protein sequence ID" value="KPJ19183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PEI2"/>
    <dbReference type="InParanoid" id="A0A0N0PEI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="369"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="781" mass="90455" checksum="FD2056E3010A6DAB" modified="2015-12-09" version="1">MVYLKLPKKYPKQGDYRRWLCGGVIIHEQYILTSAACIEDVKHFYVVSGTFTFYEGEEEYTNPCFKNGAKRAVWKCIPRNYIFDGHENDNVRWMNNDLAVVKVEDEFDFERRMRGCEWINTRSGSTRQALLESNVILISKALCKSRWGPRYHNIIENYMICTKDITAQLSEMCHDKYVDCTDIMYLGEYGGERRDMSSENLLVHSASHNFSARKRLKSWSGGFCENDHGGPLVYGTGNEAVVIGVISACLVKETNNKCYGPFLYTSVYRNRKLINCALFKDPNVNCKVFRTDDTYLEIDLKWEEEDTELNESYETEINPIRLKREEIPRKTNNYLLNYFIILILDVECIETATKLPEKVEHILNNTRRIIQGTEVTDGRPYMVYLKMPRTNKKKANYRNWLCGGVILHEEYILTSAACIQDAQHFYVVSGTYRYSEEDDRFSSSCIKNGAKKATWKCIPKNYVFDGHENDNIRWMNNDIAIVKIEEGFDFTRRVRGCEFTPRPISFNNQSHALENPGLIAQIAGWGTTSKYNDWVNRRNYNQQTLLEANVEIISKSRCKRRWGTRYHNIIENYMICSKDIGQSISEMCNEKYVDCEDIDYSEEDMRRKDIKLRTGKVPTNFSMHSALHNETVGNSSADRRGFHNGRLEGGFCENDHGGPLIYGTGTNAIVIGVISACLVKENSNKCYGPFLYTSVFKNRQFISCAIYKEVDQKCRRQFRSGVTHEEQYFSWKDHPDGPAKNELTENISNIGVSNIKIQDKDDKVFPRKGFILRSANEKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PF88</accession>
    <name>A0A0N0PF88_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable nucleolar GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01009984">
        <property type="protein sequence ID" value="KPJ20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PF88"/>
    <dbReference type="STRING" id="76193.A0A0N0PF88"/>
    <dbReference type="InParanoid" id="A0A0N0PF88"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="104" mass="11644" checksum="594365D9509AD1C1" modified="2015-12-09" version="1" fragment="single">QVDGILNRLHVAVPAARDGKARPPVIPPAAAARLQQRANKENRKRKLEREIELEQGDDYVLGMIYTTVVDVSNNNISCTNCPRSVKYHDLTEDRPQVEVIPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFR0</accession>
    <name>A0A0N0PFR0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide Y receptor type 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_00865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01052618">
        <property type="protein sequence ID" value="KPJ21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFR0"/>
    <dbReference type="FunCoup" id="A0A0N0PFR0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PFR0"/>
    <dbReference type="KEGG" id="pmac:106707406"/>
    <dbReference type="InParanoid" id="A0A0N0PFR0"/>
    <dbReference type="OMA" id="WENSYRR"/>
    <dbReference type="OrthoDB" id="7787645at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="37"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="369" mass="39087" checksum="805C46D7F4890A91" modified="2015-12-09" version="1">MYNNESAAGAVEDTPTQDHLALLIVLYVFVSIIGIVGNVSLMAALASSGACRLRTPQLLSACAADLLVCAASAPLAAARAAHMHRLPCHVTHYIESFPVAASTLSLVAMATDRCGAVLRGRENPLCARPYVAVAAVWVAAFILGAVMMIATCVSCPPLAAAHAVVTYCIPVGAVIRCHWAVRVKLTALSLTARAAHGELPLPVPLIRRPTHVIIVAGVGRERRDAVDVGDTRSKKKLQPSLLGPQPQTSTLRSRRRLGNVLIAISLIFAACWCPHAAIVISSAFGVRVPAAAAQYALLLGHAHSALNAAAYWLLNRHALTAACVAWRMPQLRVREERPSSTNEAALGAFHPRLARPAPSPRPPPSSFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PG39</accession>
    <name>A0A0N0PG39_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01057546">
        <property type="protein sequence ID" value="KPJ21582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PG39"/>
    <dbReference type="InParanoid" id="A0A0N0PG39"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="63" mass="7637" checksum="E84BE445E7E610FA" modified="2015-12-09" version="1">MFLFSRIEKPVYKKEEEKSNEISNLETTQEVEIKEEPMVVDSVEKEVVEQEKTVCFFYLYHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7P3</accession>
    <name>A0A0N1I7P3_PAPMA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RR48_02667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I7P3"/>
    <dbReference type="InParanoid" id="A0A0N1I7P3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="73" mass="8130" checksum="5D531FEEF9BD43FA" modified="2015-12-09" version="1">MLFLKKVVAAGETHESVSAKQTVEQTEDDTTRSNEPTKEDDSVTTMTQLDNDSQKEQKSSPTAKTQRTSQKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I7S3</accession>
    <name>A0A0N1I7S3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative zinc finger protein 840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_03673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460542">
        <property type="protein sequence ID" value="KPJ14123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1I7S3">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="KEGG" id="pmac:106711842"/>
    <dbReference type="InParanoid" id="A0A0N1I7S3"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1365"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1393"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="908"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1434"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1437"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1455" mass="163968" checksum="73CF5E628C63B693" modified="2015-12-09" version="1">MDSRVQCPVCTLYLHSGMTLESHLDTHPKDQVIKALCSLSSKNTNYGSRTTTPSQSERSYQSRSRTPAADDGMRWMGSHQSLDSEKYWRRTPSRSKLTPLSNPSRNVTPDIRIGDVSFENNHINHGGQYSENSYTMKLDKTQQTYASNVRVAEFDQQYPYYPEQSEDREIKYSRSLDYNTIDSAGNAFTYNMPQIAPKTNTSVASTLVPPKKSSDLVKLMPKPEFVKLLPKSNNILFKNMSGVQYIAPGVNVVMPSSPFVQKNVQSNMIMSGNLPPNPTLNTKGGAQPIIPNQYNQMGPSTFSPGTTVVTQNSQIIYREMVHNLDGKPFISTMPNMLGGHDNMGNVTQSSSIYQNVVVVDQFGNTSCMYANPQQILQKPCNASIYPESSLLLPNEHKKRSNDDVDSNKTLIIEVSPINTPATARISDASGSSSLGPSSAVDDNSKTEETELKNEPIGATKGLKILSNIKVEVPVQHKKSMLNTVMDLTGTNDQEYPEGSVTPEKILPDLEDNNQSFSDECTQPSVASGDSLVSNAFSVIKNVGNPPAYKDSPSKSSIVGSKIETDFSDSCPVPDLICNEKPSISPCSELSEHGDNSTDNVPLSPKADSSRSSLIAMNESVEESKFLHKESKKNTLRLNNIYVKKHKKILQIKNAKTNLSLESSNKSEMEPLPSSSMCKTPENFSMNKIHHTEKMESPKTSSLHTVSIEKLKGNDHNEFDADTEEQSMDIEPIAPSSLNDSNQFSMHEVKVKEEFNTSNEGGFSNQGRPLQNIPQLESLRPINVISYCNMVPGDFDNDSNHRELLDLEASSKNKQFVNMMNENYFGDNIYADYFTPDRVESFAAQKESNFREGPKDNMYIWGEPSQKESEFVLPNFIHESYKIAESNGADYSEMGEGCNIGMADRCEQDSKVDMLSESRSEGETPLNICADERMPPRGELSGQESNGDMESPWSGMYNEVTPSEPYDLMARESWVSDGSDVDANEKRDNIEDELHFAKSRLHTCSQCGIKYPSLKELRAHKALAHSLPTCSNGKTSYSRLVTARSIKKEEKLDETVLERNLLTIDSKESMATTMQQVYDAIAEAKPAIETLVKQETKRKKKDYICPTCKVDQLTEVSFNAHLKIHPLECLTCGKCFFKRGSLALHMKTHLGIKNFKCDLCEKRFVTRQKLTEHRNVHTGRMPIKCTVCDDTFRRYSNMAQHRDRHHFQKRAKVRDFVCHCGAVYHSRAKLLWHKETHDSKPKSCLFCSDKFVHSSSLTRHVRRTHNAHFLSDKVKGKEVNVPCPVCKQIYLRSNLRAHLLIHSGKKPYPCVICNKSFTTKWNLKLHRWTHMSRSAKPFKCHLCKGAFIRYTEYISHMNSHKSLRPYTCNYCGCQFIRKYNCQRHVREHEMAKKFVCKVPECGKSFHRSYYLSEHMKVHSGARPFSCNICGKTSSNKSNHNKHVKIHHAREPVATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I969</accession>
    <name>A0A0N1I969_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peregrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_02784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I969"/>
    <dbReference type="STRING" id="76193.A0A0N1I969"/>
    <dbReference type="KEGG" id="pmac:106709102"/>
    <dbReference type="InParanoid" id="A0A0N1I969"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="471" mass="52812" checksum="A4B5AE7ED0A61BB0" modified="2015-12-09" version="1">MGLDFDVLEFCKKLRQNRPPPYQCPLEKCDKVYKSLCGLQYHLVNYDHDNPTPATPTVVRNICRKKGRTRAAVPTGDIALQSPPKEALTFAEAQKVVQFEIDGKISRIPIDQPLPIISLEEWEKKNAELEKPLPVVEPPPEPQVKLPEASFRLIPDYNERVCDAQPRPNAYIRFIEKSAEELDGEVEYDVDEEDTAWLALINKSRAKQGLPPVSVDTLELLMDRLEKESYFQATQSGQQTAATVDEDAVCCICMDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSRLVNCVLCPNTGGAFKQTDQGTWAHVVCALWIPEVRFANTVFLEPIDSIEMIPAARWKLQCMVCKQRGAGACIQCHKSNCYSAFHVTCAQQAGLYMKMEAAGSGRDPSQPVQVAKMAYCDAHTPQHILQERRAQDSEGDSKSTDLSAIRQKGRDKIKQVDMTERKIGDAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I9C1</accession>
    <name>A0A0N1I9C1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_02753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460601">
        <property type="protein sequence ID" value="KPJ13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I9C1"/>
    <dbReference type="STRING" id="76193.A0A0N1I9C1"/>
    <dbReference type="InParanoid" id="A0A0N1I9C1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873777" evidence="8">
        <location>
            <begin position="22"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="341"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="847"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="875" mass="97100" checksum="A0F556C22CE6D4BD" modified="2015-12-09" version="1">MIVSRTQLVLFCALLHYRVESQQEVLIEESLEVESVQGPTGGRVELPCDVSPALAADRVGLVIWYKQGHETPIYSLDAREGISSQWSDPSTLGNRATFRTNTTPAVLMLTKLRPEDSGQYRCRVDFIKSPTKNTRLNLTVLIPPDRLIVLNESNDEVHGSILGPYDEGVEVNLTCIAVGGRPIARVSWWKSHALLANSESRASVSFSLHRPDFGTEITCQAVTDPSIPPLSHRLSIDMNLPPLSVRIQGGKRPLVAGQTSELSCQVVGARPKPLITWWKGGTKLNTVRDTTSMDGNITVSVLTFIPAIEDAGRVLSCRATQPAVSHTTREDGWKLEIQHLPVVTLKFGANIDANKVIEGSDIYLDCRVRANPWYSNVHFTHNGLTVKAGPGVLLANQSLVLQRVSRQAAGAYVCAATNALGDGMSTPLLLDVKYAPSCKSDQTINIRAARGEVLEIQCDVDSNPKVSVIYQWWFNSTTHSRRELKTSSHVQKVERPSTVRHCDVKNITYDSLIINCAPGHDGGLRQTFVLEVFDKATGVLLRNISNEESSFEVPGLSSNEVSLAIRSYNAKGSSDVFTLTCNLLQYPERRTGQVPVKVELTTLLITVLGAVAIVTIMATVSAAVCYCKYCNHREEHGKKNKRPREESSDVLLTSEKKTESADSLDKNPDIIPLNTKLSDSCSNKSSATDYSSVRPLISTTNLEEFEVPTRFSGQHTMTHYQFEHPLKYRVPNFQPNLAPMPNIGTNVYRHHHNVYEDWLRYKNALPLDSSHLLPLEKLRPPEEYLPPPVLSDLYRNPSIHPSVHGYHMENRQMSSQTINSESPSVRIHSDNNSAYYNKFGATSTLPRLNVTSPNLPKEKVETTKSTETEIDSREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IBH4</accession>
    <name>A0A0N1IBH4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_01144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459620">
        <property type="protein sequence ID" value="KPJ20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IBH4"/>
    <dbReference type="InParanoid" id="A0A0N1IBH4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="85" mass="8717" checksum="9D25652C12E8F7FF" modified="2015-12-09" version="1">MRAAAAVLRCSTHACERLGQMQSLAGLAAVLAGCSVAPGPSTRRSPRVNPASDIVQSVRDECLQNATVRSTELPPACGVTVAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1ICQ3</accession>
    <name>A0A0N1ICQ3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-related GTP-binding protein RhoV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01036604">
        <property type="protein sequence ID" value="KPJ21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1ICQ3"/>
    <dbReference type="STRING" id="76193.A0A0N1ICQ3"/>
    <dbReference type="InParanoid" id="A0A0N1ICQ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11228" checksum="29CE3E98B762DD12" modified="2015-12-09" version="1">MSELRALCYPGTDVLMLCFSVVRPETFRSVAERWTRAVASVNAPLVLVGTQSDLATDDKVIQGLKVGRNQISVSFTLAILGNRQLITNRMAFESPSNQLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDW7</accession>
    <name>A0A0N1IDW7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01012859">
        <property type="protein sequence ID" value="KPJ20990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDW7"/>
    <dbReference type="InParanoid" id="A0A0N1IDW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005873888" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ20990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="86" mass="9276" checksum="EEA8009635E165F2" modified="2015-12-09" version="1">MAGAYFFALLLILGVAQGLNRNSTINLYDSSSASLSVVRTRMLKSKICAQVKGSCTDGRRRRVKSPTKLASVIYVRTAWSPPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGU1</accession>
    <name>A0A0N1IGU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muscle M-line assembly protein unc-89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_03149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460393">
        <property type="protein sequence ID" value="KPJ15359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IGU1"/>
    <dbReference type="STRING" id="76193.A0A0N1IGU1"/>
    <dbReference type="InParanoid" id="A0A0N1IGU1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="108"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="321" mass="36209" checksum="E541DC4C60FB31ED" modified="2015-12-09" version="1">MDKYVRDLELDLRINRRFPRPAKPRVDPELDVNAQLLDISAAKHKLAVRPKKNHPKRTKNTNDNGERWLVRVVEDVQEGELHTRQGWVPASLLKEKRPEADQIAIAARRQAVVRELIETEEEFGRDMRQVAARYMRPLDKAHTPKTVFDNRELLFSNFRQICEFHNTSLLEGLKYYAGEPRLLGRALLRMEREFDKHAAYCRDEPLAQRLLATDPVVNKYFQPGQKCRRVRSICAGAGRILGSCESIRDWSQIRDITSTSAPTRTPQGLFVSARPCGDVTAAVARPAAVGLSIARSGRAAGAASRPIAAPATTPRPDHSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJX7</accession>
    <name>A0A0N1IJX7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein-related protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_01464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459757">
        <property type="protein sequence ID" value="KPJ20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJX7"/>
    <dbReference type="STRING" id="76193.A0A0N1IJX7"/>
    <dbReference type="InParanoid" id="A0A0N1IJX7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="562"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="710"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="797" mass="88207" checksum="91E91204080DB5B8" modified="2015-12-09" version="1" fragment="single">VSHHPPVSAFYVSNRKDGYVIEGSLLARSKFYGNSTSAILEGCARIHLLNWGETYITTAPYAHCKGIVIGTLSMELGGKVHIICQDTGYQADVEFKLRSFLGGADQTNAISGRIKKGKDTVATVEGYWDGKIEIKDKRTGEETNLLDVNILKEQRMPRYLMKLENQQEFESQRLWLKVSEAILNDDQPEEIVEFEEEFVISSALRRTERPREPPPPSDSDSRDELARRSKTSTISSQLTFSYVVSSQYDWGEPDTPIFPSESRSRMSRETAEQRLTAVRQVLQQYGVDAYIVPTADAHNSQYIAPSDARREWLSGLSGSSGTAVVTSSHALVWTDGRYFTQFYLQVDTSIWSLMRQGTDLAIPAWLVANMRPGSVVGIDPTTYTRTSWTTLETALSQVNVILRPISQNLVDLARANIGDPAPSRPNNPLLPLQINFTGRRSSEKISELMTQIRSRGAAALVLTALDDIAYTLNLRGSDIPYNPVFFSYLVLKPDLSAPNNVVLSWGDGSLAENVTQHLTSEGTQITTIPYQDIFDYLKNMTPTSYIISSLYVPIEGLRVYPKDGTTDITRTRHMSSSPTPEQRLTFTRVLKGQILLGTAVFPRGSTGNLLETLARKALWDVGLNYAHGTGHGVGHFLNVHEGPSGIGAALMASDPGIVPGMIFSDEPGYYEVGEYGIRHEDLVEVIEINKDADHIFAKGMVGNFSGAGAVGFYTISLAPHQTACLDVSILDDNEIKYINDYHARVLRTLGPILLERGLTEDYEFLEKECAPIQRSAAILISATPLTVIGIFSLWLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INM5</accession>
    <name>A0A0N1INM5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INM5"/>
    <dbReference type="InParanoid" id="A0A0N1INM5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ08084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="96" mass="11013" checksum="8DE10DE71607B605" modified="2015-12-09" version="1">MFRAQLRDKIQRSGGLQQWALEIEKLVRKSNPGADTKMVDTNIVQAFVDGIKDLEVSAAVRLRHHTSLKEALAHALEVESVRHNTIKFQPFWTRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP16</accession>
    <name>A0A0N1IP16_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_03579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460847">
        <property type="protein sequence ID" value="KPJ11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IP16"/>
    <dbReference type="FunCoup" id="A0A0N1IP16">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IP16"/>
    <dbReference type="InParanoid" id="A0A0N1IP16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="357" mass="40089" checksum="F8E9BC0F88B52106" modified="2015-12-09" version="1">MWRNYIRGKKAFLSDVEHISQGLNNTVTLRFSNIKIDRAHSMAGVDSCLRAPSRDNSPLRLIRELLWTLLVVNFEILRAIYRWFVPAERKDVAGQVVLITGTGHGMGREMALRFARLGAKVVCVDINAKNNEETYNMILAEKGKAYKYVCDVTDRAAVLQLAEQVRRDAGDVYVLVNNAGIMPCKPITEQTEKEIRLMMDINVNANIWCIQAFLPAMIERNHGHIVAMSSMAGLMGVRNLVPYCGSKFAARGIMEALAIEVRDDPRDTSGIHFTTVCPYIVNTGLCHKPRIRFENAMKVVNAGEAADMIVDAVLRNIMEITIPPELHYMNRYIHRLLPFPAAAAFNDFLDTGVDAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IP90</accession>
    <name>A0A0N1IP90_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p30 adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460501">
        <property type="protein sequence ID" value="KPJ14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IP90"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2739"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2752"/>
            <end position="2768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="2976" mass="350395" checksum="0CAF7B7D144FF992" modified="2015-12-09" version="1">MHRCRPFLSDYGAYASRPGLSPYAPRPGRTPYAPRPGRTPYAPRPGRSPYAPRPGRSPYAPRPGRSPHLVLTLLSRTMANEGIPSNEVEALCKAPLPFTKNTSETEEVNTNELSSTETHNDDVDNSKINKEETSQEIKNYDAKNLYDEYERRRRLQSIHDNLATKLQKALVKKLKSPEYSQRINLTTVEKYLLHDIDIPNGRRNFNNKDNELNEVPLTKDNTTEVDGRRNYVKKLTYIIDNQPNNNAQVININDANMHDLNAVNQAIASSRAGNRFVKFNNNFFDYSNHLRAQNHLNDFRQVAEYLKRLMDADNHINPYIIDILKGANELNLAEINNFDSSQLVQINKIDLEYLKKYIILIINRYGMTPYVFKLLEYVNLLEGRPRNEIYLIFKILSNQQAVYGLNRIESDQLKAHLQYILNEYGKSPLILPFVRNIGGIQFETRGNNRIHFIDFGNLDPSSHLNRDYMRKIYLHLLQIYNNNQNILQILQNINNIYNNRNSVFVLPKLDLNDYKNIYYLSQNDLYLLAKYISQIQKQIGDNTYLKELLIYIKKLQTLDQEIDVNVIKDDHNAVKGLNLTGLYKILLDINNRNDLKPEISAIINRLINMKTVTLQDMNKIMNDIKVLKDYLIQNHMFEYDQLLIKILYELNNARADENLPPIEDDTEKWITVKFQDLELIYEYLLKNEKFRSNPYLLVFIKEILQIIERGKINPYEGMVYKFRHSDLMKLYNIIQLYETDKENPIYVMIFNYLNQGKEKDHSTKYDNGTIPNPDLYLIREYFSDDQINLDIIYKFLLYEIESGNPNEVLLELLQLLKRTLLLPNGELKINVINLNGTQPYRQIKPNDLQQLYLYLQKLIEDNTISFDLLEFYRKEKRKHTLNIEIFYNATKESLNRLRNFLLILIKEHGENPYILEVLTEINHILDIPDEATYIINNTNSDLNEDDLILLIKYFSEINLIENNTDLINILEYLQDIKEKIQKGDTKEWIYINAQDLELIYQYLLSKEKFLHSPYLSLFVNEILPLIQRGKQNPYENITYKFKHLDLLQLYNLILSDEKDKNNPIYIKILNYLDLNKDVTKNNNGTMPDVDLHILKEYFGHQINMDLVFKFVTHEIKSGNSDELLFELLQFIKRTLLLPNGQLIVKNINLDDIEPLEVIQPKDLQILYLYLQELIKHEHISVKLLEYMERQKQKEKLILEIFSDVTQESLIRIRNYLLTLLKELGENQFVLDLLFEINNILGIPINYDKHENVQNGTKYDLTEVDIKLLMKYFSEINQSDNNDVIKILNYLYETQNRIYKENNTKEKLIYINLNDLEHIYEYLIGKETFRNNPYLVIFSNDILPLIQEGKLNPFENLAYKLRHFDLQKIFNLIISQEKDKENPIYKKILKYLDIYKDINNNNGTTENVDLHVLSEYFGQDQVNLDIVYKFLINEMNSGNKKEILTEFLEFIKHTLLLPNGQLKIKIIYFKEIELTGKITSSDLQRLYLYLQKLMEDDNIRIKLLDYIKIYKEIFELFSNATKESLNRIRNFLLILIKERGENPYITEVLVEINIILGIPESKNDHLYVLNGTNSEFNEEDLKLLVKYFSLINKSDKNTDVTNILEILHETEETIKNKEEKSNEQWIYINAEDLQKIYQYLLSKETFVNSPYLVVFVNEILPFIQRAKQRPYENLLYKLKYKDLLQLYNTVLSHEKEKENPIYVMILQYLDDFKDETKNNNEATQDVDFNKLNEYFEDKRINLEILYKFLTHEIESGSHSKVLVELLQLIKKTLLLPNGQLKVKVIHIDGTDPNIHPKDLQKLYFYLQKLIENEILSIELLDYMKKYKQKEKEMHDIFIDITPESLSRLRNFLIILIKELGENPFVLDLLFEINHMLGVPESNDKHPQIMNGTNFEVNEKELELLIKYFTEINIYGKNSDLINILDFLQETKEKVKHDNEDSKGDWISVNVSELELIYQYLLSKEKYLNSPYVELFIKEIRPLIQLGKEHPNDIVIYKFKVMDLLKIYKYLVSHEKDEENPIFVRILHYLEHVTNNITKYDNGTNVDLNVLNEYFGDNQINLDIVYKFLLHKISTGNLNKELVDLLEVLKRIQLPNGELKVKIINLNETEPKQINPKDLNEIYLYLQNLIDDNTLSIDLLEYYTKNIKEHKQIMELLSNTPKESLNRLRNYLIVLIKAGDGNPVILQIIFEINRILGIPENDDKQRYNVNNTNLDESDLETLEKSLSFINGPDNIDILKVIENIMETKKKIKEQQDNTKESKLFKSYVLEIIDDKNISPHVKFIFQHLLDVGFYRLNQSSGYSEFDFILREAIPNLGPGDLNVLIKYLQMLIHKFNPVYLVQRLLPYVNKIRENYKYDPTVKHINTTHPNDTLVVNITRHDLDVFNKYLLKLINLYGENSNILHIIYKINNIKETSEKEYDWFKLITKNSNAAPTLKVGDINDIIKYLVNLINKQGATGQLIKILRDFSNLPKDTIEDVNRKVTPINSTHTLVILDDDDVNKVKSNLVKIINDYGSNPYLVNILRVISPKGQDDNSVHSNQPNIYTFTKLNQNDLNILTNYILHLIEQQGPSTEFIEILYFIYEINGDVNEERKDNESEQYVLEITKEINKLRDNKIIEILRNMDRNTLITLYIDMLETIFSTPNINNDFTRIMVKLLEVYKKEESPIKKYIILKWYEYLIQNKGVSYNTLRNPDFINNLLELDDNNGTNIVITTDKYSILTPHDYSKDIDKILNELINNTLRNKPPKSDSLQEDSRKMNNSTDERKPDLRDRIEEEEIKGKSCLQANRKFKDISKVLNKIKKLHRHGIDLSNDDLERIFDIVVVFAKQLKYERHRSKIQTSLLIAELENRLLSQRTEKCTRSDTVKQIISTVVVHLRDIISYLKTANFSKDEIMIIIKSTLEDDIMPDIKAISVQECTSAANKEILDALLSNIYAKTYEQDENMGEVTDLEKFSTENLLKEMSKVKDLSTSQGETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ60</accession>
    <name>A0A0N1IQ60_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin-likey-like domain family B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459946">
        <property type="protein sequence ID" value="KPJ19139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ60"/>
    <dbReference type="KEGG" id="pmac:106720522"/>
    <dbReference type="InParanoid" id="A0A0N1IQ60"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF5">
        <property type="entry name" value="FI18040P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="171" mass="20108" checksum="1AD507949163B05F" modified="2015-12-09" version="1">MIVVSVSLSNAPRRSRRGVSAQEWQRPLTRYLPVDRDDFDLRRHVESAGHQIELCPYLTINSTSCRGYLHKLGAKFHTWSKRWFVFDRETKTFVYYWDKTEKKPRGGAYFQVIEEVYLDHGNTSKSPNPQTTFIVKTRQRQYYLMAPSGEAARIWIDVIFTGAQGYTEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQC9</accession>
    <name>A0A0N1IQC9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Sulfiredoxin</fullName>
            <ecNumber evidence="2 10">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_02547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2 10"/>
    <dbReference type="EMBL" id="KQ459781">
        <property type="protein sequence ID" value="KPJ19988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQC9"/>
    <dbReference type="FunCoup" id="A0A0N1IQC9">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IQC9"/>
    <dbReference type="InParanoid" id="A0A0N1IQC9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="71"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ19988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="110" mass="12384" checksum="28C6650742F2662C" modified="2015-12-09" version="1">MTSIHSAYIEEVHDVPISVITRPFVPELDEKKVQSLMETIQKEEEAGNVPPIDVLWIKGSEGGNYYYSFGGCHRFAAYKRLNRPTIPAKLIRSTVTDLQTYLGSSTPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQJ1</accession>
    <name>A0A0N1IQJ1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01020499">
        <property type="protein sequence ID" value="KPJ21085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQJ1"/>
    <dbReference type="STRING" id="76193.A0A0N1IQJ1"/>
    <dbReference type="KEGG" id="pmac:106707346"/>
    <dbReference type="InParanoid" id="A0A0N1IQJ1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="17883" checksum="655466EBCB860C88" modified="2015-12-09" version="1">MAKKLHYFDLNGIAESIRYLLHYGGQKFEDIRYEVKTWPDKNIKDMLPFGQLPLYEEGNMKLTQSLAIARYVALKVNLLPTDPWEQALLDSIVLTIYDFWTKVVAYFKEEDPKRKAELKREILEETIDFYFSRFEKQLKDNKGYFNGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PEZ3</accession>
    <name>A0A0N1PEZ3_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Octopamine receptor beta-2R</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_02488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461157">
        <property type="protein sequence ID" value="KPJ08080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PEZ3"/>
    <dbReference type="FunCoup" id="A0A0N1PEZ3">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PEZ3"/>
    <dbReference type="InParanoid" id="A0A0N1PEZ3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15066">
        <property type="entry name" value="7tmA_DmOct-betaAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000271">
        <property type="entry name" value="Octopamine receptor beta-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="86"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ08080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="427" mass="48468" checksum="B080DA3C832AE3A5" modified="2015-12-09" version="1">MRLGVISDICFDNGFRIGDFIGIEVWDIIVNLSPLMDQVNVSRNESDNATASGGGGDGVGDEWPQVVMFKLRTAVLLLIVIAAVLGNLLVIVSVMRQRKLRVITNYFVVSLAFADILVAMVVMPFNFSVQFYNEWIFGPVICDLWNSSDVYFTSTSILHLCCISVDRYYAIVKPLKYPIKMTKKMAFVMLAATWLSPITISYAPIFMGWYTTKEHILTRELNECDFKVNKPYAVISSSISFWIPCTIMIFTYLAIFKEANRQEKALHARAGNAMLMHRHSREVGDKNGALHINANTPTKDRNILKMKREHKAARTLGIIMGAFILCWLPFFLFYVSTSLCDTCEYPEVVTVIMFWTGYFNSALNPIIYAYFNRDFRNAFKNTLACAFCSFCKRSASDLDAMERLERRGSAQLRVPIPSRRTSDLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFB6</accession>
    <name>A0A0N1PFB6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gamma-butyrobetaine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_04976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460970">
        <property type="protein sequence ID" value="KPJ10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFB6"/>
    <dbReference type="FunCoup" id="A0A0N1PFB6">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFB6"/>
    <dbReference type="KEGG" id="pmac:106716042"/>
    <dbReference type="InParanoid" id="A0A0N1PFB6"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="170"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="433" mass="50616" checksum="B57ADF241A4E55CB" modified="2015-12-09" version="1">MFCLYLYGEQFIGSRSAASMLLIKRLRNTALSRLTRELLNTNSLSFRSGYSYHSLEDAITLEINGETLNFPHVWLRDNCQCQQCFHPSAKSRILNWSKFNLNTKPTQVHKDENFVRVTWDDGHTSQYRLDWLKFRSFTKKNQQQYDKELYKPPKVTWKGDDFQKICSTNDYNEIVSSDKALFKWLNDLSTYGVSLIQNTPNDETAIESIVQRVGFPKQTHYGVKFIVQNVPNTSNVAYLSSNLQMHTDLPYYGYCPGVNLLHCLVQTKSDGGENTLSDCHYVANYMKEHHPNQYRILTDTEIEWSDIGVENGNEFYKLYRSPVICVDKLENVSRINFSIPQRGSHFPGPIELVRPWYEAHSLFFELNRRFSAKVKVDTGSILTFDNIRLLHGRNQYQDCGNNIRKLIGAYVDWDEVYSRLRSLKVKLEKRDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFL8</accession>
    <name>A0A0N1PFL8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C12orf4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460820">
        <property type="protein sequence ID" value="KPJ12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PFL8"/>
    <dbReference type="FunCoup" id="A0A0N1PFL8">
        <property type="interactions" value="2138"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFL8"/>
    <dbReference type="InParanoid" id="A0A0N1PFL8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="523" mass="58269" checksum="9AB5DD445CAEFE7A" modified="2015-12-09" version="1">MTTERTETIVHNATKTFKYSFPTCTNEELLFKLVVPVEIPYDGSPRELLQRVINMFHIPVYLEDELNEKLAQFISNETREFHNSRDEKLLNQLKNNELNVDGIVKQWEKLFKENVVEFAEQKGTSDEEVFAAAYHKLVHSPALDTILQVENSYAKTVSNMMQSRDEDINKLTERQTEEMEEKMRLLNVSTTEEEINETAARQFEAQSVAAARWESQLDALRHTQRAAHRAWLMAALDHYQGQAELATPSNSPLTTFPPETGELVAPGGPVEPRPQLEESFTIHLGSQLKQTHNIRLVAADMLDLCALNHHDNGAAARLQPALALYSGELTGAVVLCEAGAAGAGEPPQRLLRLAAAATEHHFDDINRQLRHIAEAIREPAGECRPHGSPNCTYRNVMKRFVRSHGTLLRADITSRHPAILGLRNILKAACCNDVTTISLPLLLRNEITEEMTAAWCVRRAELVLKCVKGFVLEAAGGGGAELRTLHAALPPHAPELFAAVQSLLPSVFRVAGPLRAPRRVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PFN8</accession>
    <name>A0A0N1PFN8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaoptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_04962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PFN8"/>
    <dbReference type="KEGG" id="pmac:106717453"/>
    <dbReference type="InParanoid" id="A0A0N1PFN8"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF392">
        <property type="entry name" value="NEPHROCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879721" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1377" mass="157297" checksum="257FD57C00FA7DF0" modified="2015-12-09" version="1">MGICTQLSKVEFGIYAFLFIIHIQILQGEEQPQCPSLTENPICPCYNFKEGLFLECPSATSGVVRSVLLKIKGTIQSLSIYDLDGSITELKQDLFSPQTKIVNLQISQSNINKINPNAFLAIHDSLQSLSIISSKLNTVPHESFSKLLKIEALDLQLNEIKEIEANTFKDVKLKKINLKANKLANISENAFYNLEDSLTELDITENFLEVFPLTSVGGLYQLSHLKLAWNKIKTIPDSYNITINNLVNLDLNSNLFIKIEREWLKCMPNIKTLAFFSNQIQTIDEEAFYPLENLENIDLSRNKLIQLAQNTFKRNLKIRTIDLSYNHLHQIEGVFSNLLQLSEIFLSDNNILEIPFNAFQNTQGLTVLNLEHNALHKLHSNCFSSLKNITQLHMGTNFLQKIPSDIFKFNTKLVTLSLDNNEINELDEFVFNTLTELREIRLQNNHLNYIKRNVFSPLPGLLELHLQNNFITTIESHAFITLRKLQHINLQGNLLTTIGDIFPNRNSSLVSIQLSANSLTLLKNSSLEGQTNVHIMWLTQNKIKALNAHLFSDLINIQRLYLKNNSIMHIESKTFIRLKRIKYLDLSANKLTALNNETFFNLTSLEELHLQNNDIRHIGKDTFQYLVKLKVLDLSDNKITILDLFLAPLPIKHLRINNNLISTIEINSLKTMPNLSELEMSNNFLNWENIIEVQIPVLKSFIISKNNFSVLENTTFSQLPSLQSLTLESSNISQLRPATFIKNQNLLRINLAFNMLRDLHKDVFAYTTILQELNLKGNHFSDFPHVALFNISSLEILDLCQNQLKSIDFFKFVGLQNLRTLNLCKNQISFLSGFNSPALKNLITLNLNNNKLTVLPPNFFQHSLGLKEIDLSNNIFKHIPSNGLSETVLPVLATLNMSYNPLIQLLQTYPLKQFPLLQELVVTKTNLTIITSKDFENFPSLKKLTLSANDIIRLSPGAFSKLHILEVLDLSQNKLENIPRERLQGLYSIRLLNISRNTLRELEEFTPDLQNLQKLDISLNHLTRITKDNFRNLQSLVELNLSGNWLSFISSEAFQNIHKLTYINLSRNYIEKIQMKLLTGLETQIKSLILEENPITCNCESQDQWKWMQEHRKIVYKGTRNLLCEHPDELQGFRFTELTPHKLCDVPIVLRVAIQDIQTYSVIVSWQSRNQTGLSGFQVAYFSEQNTNSIRGKLLNLTARSTRLNHLTPGTRYYICVIAIGNFGIPTDSSTTDARVALPKENPSITLFGDEHQFNYLKSSMNDSLTTKCTTVRTIEIFGAAMDSPFSNTYLGLADILTRRLSLVVGCCIGFIVFIVLVSALGYIKTKKRPVVIKSEVQQTPQYISYDNFSTSNPDGQTTEIDLNTIMDKSKIQFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PHA8</accession>
    <name>A0A0N1PHA8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General transcription factor 3C polypeptide 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460226">
        <property type="protein sequence ID" value="KPJ16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PHA8"/>
    <dbReference type="FunCoup" id="A0A0N1PHA8">
        <property type="interactions" value="1462"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1PHA8"/>
    <dbReference type="KEGG" id="pmac:106709266"/>
    <dbReference type="InParanoid" id="A0A0N1PHA8"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="804" mass="92877" checksum="0B208B4FEDA15B25" modified="2015-12-09" version="1">MDSVKPGCSKGNMDKMDVEKELTNKFLSGEMSFAEYSSEWYGGDDEEEAEDPNKVSDDESRPSLPQVEKIGQRRRKLTRLSPVLLGLMGEANLRFVRGDKDMAEKMCHEIIKQIPTAPEPYQTLAQIYEHDAEKSLQFSLLAAHLSPSDANEWLRLAAISKERSDVKQEMICYTQAIKAEPFNFEIHMKRLDLLTSLEEIKYPLNTLNVTRVKCYHKIVTCLPATEGEIIMKYAKMAATIYHNNRELERATAVLDAAYKKCSLLFSLEDINIFLELLITQKQYQACIEVFVSNLGIVIEAEIQTVKNSSDEIEEHTNYINCTIPCNLPIDLKSKLLICFIHLGAISLVETLLTDFLTNDVEKAGDLYMDIEEAFSCVGHHELAMKLLEPLIKNTSFDLGAVWLKHAECLYNLGRLDDAVESYYKVLKHAPQHPTARRKLYAILEQKGRIDEALDILQQDYNYVVSAKLLLDHCQELKKHNKILKYLEVGEALLSKTFPRYRHQEELSIACKTKGGIDLIHEFRKMRGENPYHEDDLHFDEEESFKLTPQEEWNFFKELLGIANDHKQYFTMQRLCFGALMSKALTSHRIDIDFYCLQACILSNDHHTAMRFIRDFTHKYPGPSSWNLLNLVIGSVDDTAHIKFLSRLFQKDSHIVRHLFLGNNFLTSGRYLVALKYFLEYHDQCREPLSAFLISVTIMIMAAQRTVDKHHNLILQGLSYLSTYKQLRKCDQEAYYNMGRVYHMLSLNNLAVEYYEKALSCAPIAKCEQHGVIDLTRETAYNLYLLYKDHSPEIARKYMFKYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PI73</accession>
    <name>A0A0N1PI73_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459717">
        <property type="protein sequence ID" value="KPJ20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PI73"/>
    <dbReference type="STRING" id="76193.A0A0N1PI73"/>
    <dbReference type="KEGG" id="pmac:106708387"/>
    <dbReference type="InParanoid" id="A0A0N1PI73"/>
    <dbReference type="OrthoDB" id="7446909at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF1">
        <property type="entry name" value="FI01546P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005879795" description="Osiris 9" evidence="2">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27579" checksum="D42A68F209E8BD6F" modified="2015-12-09" version="1">MKLTLVLVIALGAFAAAEEDNTMEIALSFVKDCKGDYFLCVKEKMLKMVDNLRASRRITIAEGVVLKGEPDVRSPKKLDSLPVDPTARDAEVNYRLMDGVVSLFETHALEVKMNPADKETVQRSLEEGRGKGGKKGGGGMGIIGLLAAKMLLGKLFIVKLIALKALATAKIALVLAVILFVAWCMKHDHTKTTYEVVPHAHHHESHHPVHVEHLSHDAGHGHGYSSGYGSDWNKNIDEAQNLAYGAYSPHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PIB8</accession>
    <name>A0A0N1PIB8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_04796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460366">
        <property type="protein sequence ID" value="KPJ15579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PIB8"/>
    <dbReference type="InParanoid" id="A0A0N1PIB8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="65" mass="7005" checksum="46B06EDE661B2B7A" modified="2015-12-09" version="1">MAKRPPPIDIRNYRCVDYSQETHKNGGAIIGEREGRGSSTGGALRRPLAAPPPPPPRLYRGPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ11</accession>
    <name>A0A0N1PJ11_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable N6-adenosine-methyltransferase MT-A70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_00404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01016727">
        <property type="protein sequence ID" value="KPJ21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ11"/>
    <dbReference type="STRING" id="76193.A0A0N1PJ11"/>
    <dbReference type="InParanoid" id="A0A0N1PJ11"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7427" checksum="B1930A6B2E4E8EB4" modified="2015-12-09" version="1">MPSSREKAVKRVGEEIMDLLSKPTAKEKSLADKFKSQGGYGILSTRDTCGVRTKREDRQARETVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1PJ94</accession>
    <name>A0A0N1PJ94_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_02261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460400">
        <property type="protein sequence ID" value="KPJ14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1PJ94"/>
    <dbReference type="InParanoid" id="A0A0N1PJ94"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="333" mass="38524" checksum="CAC619FC8A25B9AC" modified="2015-12-09" version="1">MENFSNGDTYPSPLEKFLERGAQEFTQNKQLCYMCERRMTSFMRLMDNLQLAVEVQRVFISADMCDEYKRNIMQDNLNVYQNDFIKFRNRMQLYRTNTLVVDSLETPGPRYPSNTKQQYPKTSNMETVFINDVEPLKEIGTKVHTTLLNTLEFPVALSNSNMVLTLGPDNNLYIAPCITVDGTNNTDSDDKNTTTESNNVIKTQNEEITWKDKSRNILNFPKRPDLLPKKRSLEEDVTVKKNKTHNLPLIVDCKTDKFAFIEDESKNIEQVEDTMESLPEVVKHPIRTDSAVDWEDKIPMEVISFADEKSTSMAEIKLISQPKTKEPEYIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QL15</accession>
    <name>A0A194QL15_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycine receptor subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_14526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QL15"/>
    <dbReference type="FunCoup" id="A0A194QL15">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QL15"/>
    <dbReference type="InParanoid" id="A0A194QL15"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022824">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000032">
        <property type="entry name" value="gamma-aminobutyric acid receptor subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="103"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="322"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ06084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="595" mass="68043" checksum="403F6CC7FC0C6863" modified="2016-10-05" version="1">MWQNEQNNMKSMRVEGYTCRDEFFSVGMNPRRIFLPVPTLEDDSMYLANNLVLLNMYHKYVTEMRPPSRKGQPVIVEFSIYVVDVNSINVEDMDFSSMNLRIILQDLQYHKYITEMRPPSRKGQPVIVEFSIYVVDVNSINVEDMDFRVDMFIRQTWSESRLQLPDDIFEEGDDHVTLPPEFFDNLWHPDPYFLNSKVTEIAELTHKFSSVTLYRNQTVRYAARMHAIIACQMEFQLYPMDIQSCPIYIESFSYSNQKVRFRWSEAGVTINPELKLLQYHIGEPLRLEETNGYMIDKDGNYSRLVVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLDLDAIPGRVTLLVTCMLTLVTMFTGLRADIPPVAYVKALDLWMAGCMMFVFAALGEFVVVKVLDKQYQMNKSKAQESMPRIIPVRLNGEKGSCGTVAAWEGSGVRCRKIDLTSPTSPPATTPGVHTTPTAPTPQLVGVERRQSILQRLNGEKGSCGTVAAWEGSGVRCRKIDLTSPTSPPATTPGVHTTPTAPTPQLVGVERRQSILQVAWLDADTGQERVLWREIDKLSRVVFPALFLLFVTMYWPVLLLKTKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLE1</accession>
    <name>A0A194QLE1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">RR48_14091</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Ya'a_city_454_Pm</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLE1"/>
    <dbReference type="FunCoup" id="A0A194QLE1">
        <property type="interactions" value="1291"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLE1"/>
    <dbReference type="InParanoid" id="A0A194QLE1"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="20">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KPJ06352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="380" mass="43114" checksum="B96A2688509557E0" modified="2016-10-05" version="1">MWRFSFTIFRKVVLPSIKGNVKFSKTCYSTRSRLPKSTAKLTLVSASVGVLIGAGYGGYTHYVVNSKKRPKLTLNEEYAFLNEAPPYQAHYKVINESDSSNLQLVLFQYRTCPFCCKVRSYLDSKGISYEIVEVDAVLRQAIKWSAYKKVPILLAKVDGGYQQLMDSSAIISALETYFRDKNSQLTEVIKFYPITRYTNDDGKSMTDITNKYFVMHNAAVPDQKERMEEKVEREWRQWADNVLVHTLSPNVYRTPGEALATFKWFEEVGGWKQSFPSWECALMVYGGAAAMHNLQDDVRYSLYNAADAWTNAINKKGSKFLGGDQPNLADVTVFGVLSSIEGCEAFQDLRNNTNIGKWYDDMKVNIASKKGRVLAVHAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLJ6</accession>
    <name>A0A194QLJ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="21">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">RR48_14686</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Ya'a_city_454_Pm</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="20">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="21"/>
    <dbReference type="EMBL" id="KQ461198">
        <property type="protein sequence ID" value="KPJ06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLJ6"/>
    <dbReference type="FunCoup" id="A0A194QLJ6">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QLJ6"/>
    <dbReference type="KEGG" id="pmac:106720311"/>
    <dbReference type="InParanoid" id="A0A194QLJ6"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000143">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KPJ06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112494" checksum="D5D8029E8EE36C46" modified="2016-10-05" version="1">MEDAHTKSVDEVLGYFGTDPDKGLTPDQIKRNQDKYGPNELPAEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEDAFSAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRGDKSGVQKIRAKEIVPGDIVEVSVGDKIPADIRLIKIYSTTIRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGIVIGTGLNTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFEKIEGGDSNFLEFEITGSTYEPIGDVYLKGQKVKAAEFDALHELATICVMCNDSAIDFNEFKQAFEKVGEATETALIVLAEKMNPFNVPKTGLDRRSSAIVVRQEIETKWKKEFTLEFSRDRKSMSTYCTPLKPSRLGNGPKLFVKGAPEGVLDRCTHARVGTNKVALSSTLKNRILELTRQYGTGRDTLRCLALATADNPMKPDDMDLGDSTKFFTYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFGEDEDTTGKSYSGREFDDLPVSEQRAACAKARLFSRVEPAHKSKIVEYLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDKPPRKADEGLISGWLFFRYMAIGGYVGMATVGAASWWFMYSPYGPQMTYWQLTHHLQCLSGGDDFKGIDCKIFTDPHPMTMALSVLVTIEMLNAMNSLSENQSLVTMPPWSNMWLVGSMALSFTLHFVILYVEVLSAVFQVTPLSVDEWVTVMKFSIPVVLLDEVLKFVARKISDGNASSLQHWLDGMQWIVLMWAVFFGIILYGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QLK8</accession>
    <name>A0A194QLK8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T-box transcription factor TBX20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_14182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QLK8"/>
    <dbReference type="InParanoid" id="A0A194QLK8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000008">
        <property type="entry name" value="T-box transcription factor TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="169" mass="19297" checksum="B4CDF5A4223428CB" modified="2016-10-05" version="1">MFPTVRVSFAGCRAEARYAVLLDVVPVDGKRYRYAYHRSSWLVAGKADPPAPARLYPHPDSPFAGDQLRKQVVSFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLVKVREGGGPITDLSREQHRTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMH1</accession>
    <name>A0A194QMH1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General odorant-binding protein lush</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_14293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461196">
        <property type="protein sequence ID" value="KPJ06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMH1"/>
    <dbReference type="FunCoup" id="A0A194QMH1">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194QMH1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF1">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN LUSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="121" mass="14004" checksum="C9B80A93B28BA702" modified="2016-10-05" version="1">MTRQQLKNSAKMLKKTCMAKNDVTEDLIGDIQKGKFIEERNVMCYIACIYQMSQIVKNNKLSYEASLKQVDMMYPPELKTSVKASIENCKDISKKYADICEASYWTAKCLYEDNPKDFIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QMS0</accession>
    <name>A0A194QMS0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_11691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QMS0"/>
    <dbReference type="InParanoid" id="A0A194QMS0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="66" mass="7202" checksum="549C0B268A2C4C93" modified="2016-10-05" version="1">MHRLPFRSSIRLSFRTITVVVFASRQTAGVPDTVETRAHCGERRLTGVADDGARAAISPTHSIVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPA4</accession>
    <name>A0A194QPA4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_11852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461195">
        <property type="protein sequence ID" value="KPJ06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPA4"/>
    <dbReference type="STRING" id="76193.A0A194QPA4"/>
    <dbReference type="InParanoid" id="A0A194QPA4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000582">
        <property type="entry name" value="Probable lysine-specific histone demethylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="436" mass="49402" checksum="2CED40F090803350" modified="2016-10-05" version="1">MSRRKRTKVENREVDEKLKQEDSESDQSEKSKLTAASPTLFGTRRESLSSKTSDIKEPKKEEKSVVFEDSKSDDIEEINYKAMLNSLEGAAFQSRLPFDKMSSLEAECFSDLQGASSHTFIQIRNRILKLWFEDPKKQLTQEGCVQKMEPPYNADPPLVMRAHAFLERHGFINYGIYERITPIPSPPKGKQRPKVIIIGAGVSGLAAARQLQSFGCEVVILEGRDRVGGRIVTYRKGPYVADLGAMVVTGLGGNPVTTLSVQMNMELHKIKQKCPLYEANGIQVPKHKDEMIQHLKAVITLQEKLKGNINKMTDIKELLKSMKTEKENLLSERDKVSAGEAGILHEFNLRRLNREMNQLCNEYETLITNNNTIEDKLTHLESNPPSSVYLSVRDRQILDWHFANLEFANATPLGNLSLKHWDQDDDFEFTGNHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QPH0</accession>
    <name>A0A194QPH0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LisH domain and HEAT repeat-containing protein KIAA1468-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461190">
        <property type="protein sequence ID" value="KPJ07249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QPH0"/>
    <dbReference type="STRING" id="76193.A0A194QPH0"/>
    <dbReference type="InParanoid" id="A0A194QPH0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121615" checksum="031485A843B315CF" modified="2016-10-05" version="1">MNPYKDVEDSSFTSSPHLAYEDIATKLLKDHYFLTALELHTELVESGKELPQLREFFSNPGNFEQHVSRPSDIGSMHRTPSQATLDSLDTARYSEDGGGDRGGSGGDVAVLEFELRKARETINALRANLTQFADGESALDKITQDNFDKRSLKPHEKRALNFLINEYLLLQNYKLTSITFSDENPDQEFEDWDDVGLNMPRPAGLISLFRGNKSSLSTSTNDAVTQTDGIQRVEIHCQTECEEENVCVSCQTSLDNDTDWNHELLIQAEEIELLKQKIIALETEKLNFQKLYDAAIVSLNSLTSPTSECKGLDLQIPGDNKKDGSNTSSFEPAMLGEISARGSPLRTGSVTTLDETLSINDAGDWTRVQYEYNIENNTKEMWIDSGIPTGVKESILNLCSEALNLNEPLTNDLLAELVNSDKPITLPGLLLLVADTLPRIVPHTLVSRRCEAAALLAAGAALLSAAEARRARLLHTLLTLLKKPEPGDARIICEAVCLVVKWGGAAEVLSSVAELLASRSSERRILASQICLAIAPYVPVELCTSLLLSLVALMCESSEPEVRSLGLKSACLVCVVADHKYNQLENLMFSFLKDPVDKNVKDTINVFVPTLARSALMAGKFSSDLCNRVMTNLIKSCNDNEWKNVLLNLEVIKSLVLAKLAYVINVQIVKDVNLSDCDMKTINLQDVPLESENFIDVSCYVSDSVDAKTLLLAMNSLIKDPSIRWTELDWFIDWIRKMLEIISSCKVSNHPMVYELLITLFNSYIDNFGYNFACNIMKPIFTDILNELEHKIEKLDTVSLESTVVVGIYLASVLIAVEEGPSQAEFLQKWIVYSSIRGLPAKIFSMPFKWLATHRPEVLTFFWQHLREFCASSCENASGAGIRAHIAALLTEMVNVSDVREECMERQLLPAVIALLYDDHVSVREAALSSWGSVTRACMVRGLSCGAQCWPPMEQWVGGRTLTPREAARLAEALALLVLPTVDDRAVSEQVTWCEAREISRSLELSVQETRRKCRNRSDESIQIINRGVTERCGESHELRGVTRARVRESRRELAATTNLQAAQEVGRRVTQIFHHSKNNINLQNIFKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QQI2</accession>
    <name>A0A194QQI2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_11165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461181">
        <property type="protein sequence ID" value="KPJ07609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QQI2"/>
    <dbReference type="InParanoid" id="A0A194QQI2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ07609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="113" mass="12088" checksum="02C8AFD5A7B1FDF6" modified="2016-10-05" version="1">MIAAVIINSSTRNGMIMAIKLLPVQCTFAQDAPVQAIACAHADAVAGRGSAAGRLQPPPVRQPATTARHASMPRTATPSAQTLNRLLIKQTELLSRRDNDTISVLIIYQSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QR52</accession>
    <name>A0A194QR52_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein ISCW010018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461175">
        <property type="protein sequence ID" value="KPJ07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QR52"/>
    <dbReference type="FunCoup" id="A0A194QR52">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QR52"/>
    <dbReference type="InParanoid" id="A0A194QR52"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042407">
        <property type="entry name" value="NCBP2-AS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161:SF1">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="79" mass="9339" checksum="CE57558AA859F10F" modified="2016-10-05" version="1">MPLRALFKYLANNERLVQRLADSYPVRRAAQLAISVFYRGKEKVSEMDPQKVNVLLSFFRRFSQHLREGIEDAKKQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QSQ5</accession>
    <name>A0A194QSQ5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase-like protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_12265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461154">
        <property type="protein sequence ID" value="KPJ08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QSQ5"/>
    <dbReference type="STRING" id="76193.A0A194QSQ5"/>
    <dbReference type="InParanoid" id="A0A194QSQ5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="6">
        <location>
            <begin position="499"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="588" mass="68156" checksum="86B3626262393B26" modified="2016-10-05" version="1">MALNQFMHPRNIYRTPPDFVKLFKEFEDFSTIAKMDVTGKVSIDFKDTRALRVLTKCLLKSDFDLDVVIPEDRLVPTLPLRLNYILWIEDLMISINKEYITGLDIGTGACAIYPLLAAKKNNWHMVGTEKDEDSLKMASDNVERNNLQHLIKLKKNTTASLVEHLFMEDNGMRFEFCMCNPPFYSNIQEVLDSRSPARKICLPKNAFTGSPQELITEGGELEFCRNLIKESAKFKDHILIFTTMIGHKYNMKELLLDLRAEGIKHTTTEFCQGRVTRWGIAWTYQNYDLYNLVPPRDKPRKKSIPITFVVPEISNLPYDVKHMVEKVQQLFDSLNIQYKIITKRRNETVLNFYAITNTWTNQRRKRRLLKKLEETMSKKQKCENHHECETSTSDLSIDEKSNIDTACNTVLTDKTDTETKDIGKPIVQGILKVSNKEKTVVFEMEYLEGSAGKEVRKATKGKMSEDSAENLTVKKRPKPNSKSEDSKPSKTGKTTEVETDPAVLQRRQKQIDYGKNTVGYHNYIKEVPIETRGKEDPKTPDKYTKYSRRSWDAQIKLWRIKLHKYDPNATSKTEDVESIKCEYDYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QT44</accession>
    <name>A0A194QT44_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_06181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461150">
        <property type="protein sequence ID" value="KPJ08693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QT44"/>
    <dbReference type="InParanoid" id="A0A194QT44"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="95" mass="10906" checksum="E9E44CEED70FE9A9" modified="2016-10-05" version="1">MDSTRKTDSKNQNRSQNTSYNPWNLLFNSRNRSESESSASSTNSENCQTGSQFGGYQRPARKSNEEYLYMLTNSTSFINGDLKYEFYSTMKALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTP3</accession>
    <name>A0A194QTP3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTP3"/>
    <dbReference type="STRING" id="76193.A0A194QTP3"/>
    <dbReference type="InParanoid" id="A0A194QTP3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="876" mass="101702" checksum="B617B2BBF4736426" modified="2016-10-05" version="1">MDLARRFRWRGGGASYKLVLQYVKSPLALVDCSRNERVLYCDILDGYDLVAKGITKNQATLPELGLKDIFPNGSWLEAKQIQSAIEARKHLIAAERIEKSGVLSHAEWRENLMLTEVIQKSGGHWQFIKYYYYRRLSLNYFQNSLLLKHNDVKVSLQQAYSLLLRDKNSFLEYKVYATLSRWGYKVFRHTDTNVSDICNSDETNETKIKSDGSQSSLTEHIDDKLKVMESEQNNAISESNDDEERCNLKRKSSLIDDDSDDSQTNKMGETSNCKKPKIKDQTSIYVYKIEKHKNRQFKPCNAKKLHKYFENIPNFVNNEVVTIKVPDKQYIPNSISFSKTTYILNLNSVRTKQLRAQSPQESQTSSSTGEVNRGHFMRVRGNYNRFQIPPYIMYSPMNDPRNNITYRPFNCWHSYVRANYYHYNMSFQRPLLGNFVFTPRFQYFPRFQNFNRPRYNFGRPYNRRQRKRSQDSTKHFHLESLMKLAARLKNLATSGLAHSEPLAALNNLIQTYNTRYGSKIKLSDDYEIVEDENILDTIELDDDGEQIKKKPRLDSNPDTYTINFNNIKQLAERLKNLENDNKSSARHRRAFSNLIKTFNKSYNADIYVTNNFKVLDRSFITLESSSDSDCLIDENDNSSGKKVRNPFNILKRLSEKRNKSLDAPGTSSDTLNEKSDVDDYRDVIQKNLSKEWIPEDNDFGRPEICGSVDEPNTANLFYEFIKFHLENYENWLDLKVSFLSSLEETADFFRKKTDIESVQNRSLVSPEDCVDIVSVLKKLSIIKSHNTTGETSLKIDFNVYNRDVQNFKKTNPPAPHFRISCLDESEKFPSGQEIVSLHAKYKDDVRIVFAIVGTGTINFVQINPISLPTHISSNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QTP7</accession>
    <name>A0A194QTP7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chymotrypsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_13114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461155">
        <property type="protein sequence ID" value="KPJ08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QTP7"/>
    <dbReference type="STRING" id="76193.A0A194QTP7"/>
    <dbReference type="InParanoid" id="A0A194QTP7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="263" mass="29857" checksum="4DB27DAE791DDFC2" modified="2016-10-05" version="1">MELVKMILFAPAFFELFLISLPLIGGERAPQEFGRFHGSLQNLTGHHVCGSAVISRRHLLTAAHCVYRVKPRYIKVIVGTVDLNKGGKQYGVKSIHLYPEYNITRRINDIAIVKIRGRFNLNYIDVLQLPKRDLQDGDPIILSGFGAKKPYGDSSRKMYALNLTVFCQKTCRYAMRYSRDVTDTMFCTFTRIGEGTCHGDSGSPLIKDNVLVGLVSWGIPCAMGFPDVHTRVYPYLEWIKSIIFEKQYKTLELKTEVKLTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QU30</accession>
    <name>A0A194QU30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_15179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QU30"/>
    <dbReference type="InParanoid" id="A0A194QU30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="245" mass="27386" checksum="24DDBE4F60FD7D05" modified="2016-10-05" version="1">MRNVTSQTNLLEIILPSTSRTSRKGVPFLFLELKAKEIFPERRIGTMNLRKLILLAKLLKYLLWRRSQIESTTHDLEMSPERRAKSIAGSRSSRSGATTGKTTGDVTGNTTGVSEETENTQEADAPQDPEDPRDTATYEIITDPQDLRKEIQEIVAQYSEALFLDDIEGACPPVITLDDQQPENDEINTTDKISLDDCEGEGEPDAVELKELVITNQPTVGEAGILDDLEFMDEEPQDDDDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUN3</accession>
    <name>A0A194QUN3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidoglycan-recognition protein SB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_15379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUN3"/>
    <dbReference type="KEGG" id="pmac:106717160"/>
    <dbReference type="InParanoid" id="A0A194QUN3"/>
    <dbReference type="OrthoDB" id="7939567at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="89"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ09238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="28226" checksum="658514B9B40C54E1" modified="2016-10-05" version="1">MQPLISPVDHESRTNSYRAEEENRGTEATPLLQRFPRYQSNDNHYRTRAVVSLLLLILLSGIVIGTYLLIIQSRSENVLPPIEVPELYVSRLQWDKNKEVDQVNLVPQLKKNTVIVVQTDTDGCNCTITCSTLLNSMQENGTRLQYNFLVSPDGETFEALGWRRNSVIFPDYSANAIILAFIGNYTQEAPSTAQVMQAKIFLENSISQQHLDLNFDIIGKKTKELPKYLFLELSKFPQWNKQLSDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QUZ9</accession>
    <name>A0A194QUZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Charged multivesicular body protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_07865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461137">
        <property type="protein sequence ID" value="KPJ08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QUZ9"/>
    <dbReference type="FunCoup" id="A0A194QUZ9">
        <property type="interactions" value="1324"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QUZ9"/>
    <dbReference type="KEGG" id="pmac:106717508"/>
    <dbReference type="InParanoid" id="A0A194QUZ9"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="206" mass="23790" checksum="7BF3178C74DCEC4D" modified="2016-10-05" version="1">MGALFGKSKKPVSRVTEQDKAVLQLKQQRDKLKQYQKKIELNLERDRQLAKKLLSEDKRDRAKLLLKKKRYQEQLLQNTDTQLEKLEQLTHDLEFTQIEVQVLEGLKTGNDALKKVHDILNIDEIEKIMDETREGIEKQREIDEMISGQLTSEDDEAIEAELESILDVADQLPDVPEDILPEAKAEDIPARPQRVKNKTNKVAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QVB6</accession>
    <name>A0A194QVB6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein zer-1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Zyg-11 homolog B-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_15405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyg-11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QVB6"/>
    <dbReference type="FunCoup" id="A0A194QVB6">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QVB6"/>
    <dbReference type="KEGG" id="pmac:106717298"/>
    <dbReference type="InParanoid" id="A0A194QVB6"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000111">
        <property type="entry name" value="Protein zer-1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="9">
        <location>
            <begin position="180"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="8">
        <location>
            <begin position="389"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ09264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="764" mass="86331" checksum="345135E824F9C38A" modified="2016-10-05" version="1">MATKQENLPVSENNPESLVEICIETIARNLDAISIRDPVTLLRRLKHDIILPVELCEKFIDIFQRKHVIDDKIANIFRDTERTKINNLKLRNSAVTVEGLLSFMVHKPKTVELIHCVDLTQVAINVINDHSENLVSLKFGPLCYTISQNRLYQKEYILSIPQLRKLSIQCRRATVFPILLTQPLYCLRHLELSELTQSNYLTALQGLETLESLVLYNVRIETGLVEWICTLHSLKHLDLSQSNERLGVFPNPNLMLSRMMHCLPRLMSLDISGTNLAGTGAAPPPVEEVGASEVPAVPVRCDIPGLVSRVNNPLHFLGLYGTHNGACRWHDIPAKVITGDTNEEQILTSAKVYMGRPAMLAHVLNDLYYLFRYDQCESVQRSLAVVLEAMRRHIPEKHIQISGSATLFYIVKGKEKDKLGMKLKRNILNALLDAMEEHRKDETVMRNGCITICQFKIPADVLCEYERLVQMLLSCVPYLSQEGFVQRVSIYLLNSLACQVDGNRKLFLGKSGLIEKMVHLISARHECSICDDVLEVAWSTLWNVTDETPANSSRFLECHGMELFIACLETFPQKEELLRNMMGLLGNVAEVAELRPQLMDTEFLDVFYDLLDSSSDGIEVSYNAAGVLAHIASDGEEAWVVANPPRAAVLARLAMAVQTWNLRDERNINYRSFKPILGLLSVYHTPQCQHWAVWALANLTTVYPQKYCSLVIAEDGISLLKKIIKDPRPYTVIKDLACMVINNCSRYTAQDTDNPPPDPVSYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QWS6</accession>
    <name>A0A194QWS6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_13393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QWS6"/>
    <dbReference type="FunCoup" id="A0A194QWS6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QWS6"/>
    <dbReference type="InParanoid" id="A0A194QWS6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ09759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="180" mass="18870" checksum="9DAEA2FD6E4B9DE3" modified="2016-10-05" version="1">MQPAHICDEMQLCIVAFGALVAAANAGLLGYGGHGAAVSSQNIVRHDAGHGYAGSSYAPVAQAYAPVAQAYAPVAHAVQYAPVAHYAAPAAAYSGHDYYAHPKYDYTYSVADPHTGDHKSQHEIRDGDAVHGSYSLLQPDGSVRTVDYTADDHTGFNAVVHNTAPAVHPAPAPAHGYHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QXR4</accession>
    <name>A0A194QXR4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gonadal protein gdl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461073">
        <property type="protein sequence ID" value="KPJ09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QXR4"/>
    <dbReference type="FunCoup" id="A0A194QXR4">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QXR4"/>
    <dbReference type="KEGG" id="pmac:106716666"/>
    <dbReference type="InParanoid" id="A0A194QXR4"/>
    <dbReference type="OMA" id="CVLNESI"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="20633" checksum="BFB7B3D4CC4C02C5" modified="2016-10-05" version="1">MEMEVSEPTPEALQRKLYFLLEQLQDMARELPPKYQMRVPIELLSGLANCLLNDTIFEIVKGLMEIQHVTEKHLFQQRLQIINQHTMEIQEMMKNTVPEQQEVQKTNLLRRHKEELKQTDMKLVLQLDQKVSDQQDTLEKAGVPGFFVTSKPIEVKVQMYLLDFILRLSKMDIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZA6</accession>
    <name>A0A194QZA6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthase regulatory factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_07798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460930">
        <property type="protein sequence ID" value="KPJ10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZA6"/>
    <dbReference type="STRING" id="76193.A0A194QZA6"/>
    <dbReference type="KEGG" id="pmac:106715425"/>
    <dbReference type="InParanoid" id="A0A194QZA6"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="346" mass="38693" checksum="B9AEDEF008625E09" modified="2016-10-05" version="1">MWKYVTRRIRDALEKSVNHFDKRSSTGVVNSAGSTLSEEQNKRIGAPSCWQNPRKCWKSFCNDNDTKSKRWNFDDLNRTWIGAITWSSALVIGWYTSQLIHLKLKYKCRDDKKNCYPVNCLLSSLHPYIDYISKSAVGLNSSRKIEQAIASVPIHVHLLSNENKTEEKASTSGSNSSTSSSDELGEVLNSIENRLGLAAIENGQHQDGLNLLRSAANRNHAPALFNLGLCYEMGMGVAIDEKMAMELYRMAATQQHPGALYNLGIYYGQGRGGLTRDTATAKRLLRLAAVQGQQDAIKALSSLDDAPEPYTDKWENNLYSPDEHFAPTHSVLFVENTSHNYNVLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194QZR9</accession>
    <name>A0A194QZR9_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_15227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461108">
        <property type="protein sequence ID" value="KPJ09086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194QZR9"/>
    <dbReference type="FunCoup" id="A0A194QZR9">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194QZR9"/>
    <dbReference type="InParanoid" id="A0A194QZR9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000056">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="318" mass="34778" checksum="22D3B791BD81CDBB" modified="2016-10-05" version="1">MKYSSIWTGAIQMQAVSLVFPQGDLFSGLNDGLLSRAEALAAVDISKHQSGPQPGPPLPQLKHDMVYHHGVGGPPSHNARPHQMGHHGMEGLDMLDPLTSSSMTTLAPMGESAPPHHQLHGYGAMNHVMNHHHHPGGLTHAPPAHLGHPAAALHPDTDTDPRELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICRFESLTLSHNNMIALKPILQAWLEEAEAQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R0W4</accession>
    <name>A0A194R0W4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_10070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ460890">
        <property type="protein sequence ID" value="KPJ10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R0W4"/>
    <dbReference type="FunCoup" id="A0A194R0W4">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R0W4"/>
    <dbReference type="KEGG" id="pmac:106715245"/>
    <dbReference type="InParanoid" id="A0A194R0W4"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.430.10:FF:000002">
        <property type="entry name" value="Dihydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="10">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="185" mass="21209" checksum="42DC511B2B50B7C6" modified="2016-10-05" version="1">MSKVKLNLIAAACENMGIGVNGTLPWKLKKEMAYFTTMTTKVKDESKLNAVIMGRITWDCIPDKYRPLNNRVNIVMTHHIDEVKAKVPEGVIVVPSLDEAVKYIEGREDIESTWVIGGSSIYKAAMEHENCGKIYLTEIQRSFDCDAFFPNIDKQQFHLVDEEEIPGERQLEGDISYFFRVYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R195</accession>
    <name>A0A194R195_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RILP-like protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_08305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460878">
        <property type="protein sequence ID" value="KPJ11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R195"/>
    <dbReference type="STRING" id="76193.A0A194R195"/>
    <dbReference type="InParanoid" id="A0A194R195"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="237" mass="27025" checksum="A30B1C3D707BF7C5" modified="2016-10-05" version="1">MTDYDDDITVVDVYDLASDIGKECEIIIEKYGPDAVTALLPKVINALELLENFAVRNEKENQSLLELTAKISQLENDKIEKAEYRQRFEKHGLTMALSPLTCEGSKFHPEDNELISYDSLSLKKELRAFEAPKSDEHVCVDIDAGKHKRCTSAPPSPAREHDQEVLSRLSSTAEKQRATLRHQEVQLQEKQQLIESVSTHHVHYSLVQVGSFEKRYYVVDTSFIFRDQPCGKNFAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R1J1</accession>
    <name>A0A194R1J1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_14749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R1J1"/>
    <dbReference type="STRING" id="76193.A0A194R1J1"/>
    <dbReference type="InParanoid" id="A0A194R1J1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="93" mass="10628" checksum="F27489AFF6B76B7D" modified="2016-10-05" version="1">MIYLNHRDNNCEELRVRFADHTGELTARLPANILQNTLGYTTQQLKAMSSEERAAVRWRLLLEQCCAKLAATPHRLIVLSLRKANPADPIPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R2E1</accession>
    <name>A0A194R2E1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KQ460855">
        <property type="protein sequence ID" value="KPJ11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R2E1"/>
    <dbReference type="STRING" id="76193.A0A194R2E1"/>
    <dbReference type="InParanoid" id="A0A194R2E1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="163"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="470" mass="54759" checksum="FFCC05EE108CC358" modified="2016-10-05" version="1">MHPPARPQCRLTSSPSVAAPYVLSISADIFARVDRYYFFLVQNESLALLLVSNSEGKYVLHFNQSISQATTNKTNDTSLETQHVEAAQTSRLRYHTSNIMFSNKSYSPSKDMSYKARDNSADVHDGYTDQQQQQYLKHLKQLKNEFEQRWRSTPTFSITFDELDRVRTLGTGAFGRVVLLRHIKTGKFYAMKILEKEKVVKLKQVDHTLFEKRILEAIRFPFTVSMEFSFKDNSYIYFVMPFVSGGEMFTHLRKMVKFEEPLAKFYASQVILALEYLHFCNIVYRDLKPENILIDKTGYLKITDFGFSKILQGRTWTLCGTPEYLAPELILSKGYGFSVDWWSFGVLLYEMNAGYPPFYANEPMKTYEKIVAGKYRCPSSFNPDLRDLVRNTLQVDITKRFGVMKDGVMDFKSHKWFRGIEWDAIVNCRYPAPFIPKYKSPGDATNFERYEEETLQPASYCRFESEFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3B0</accession>
    <name>A0A194R3B0_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein cappuccino</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_06384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. Cappuccino subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460845">
        <property type="protein sequence ID" value="KPJ12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194R3B0">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R3B0"/>
    <dbReference type="InParanoid" id="A0A194R3B0"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF7">
        <property type="entry name" value="FORMIN-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="911"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="843"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1336"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1336"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151210" checksum="A9CB15C275BA01E9" modified="2016-10-05" version="1">MQLATSRVNFTNSSVAQYNYVKLLNKPNSAERGVHNVLTVLGLHSDDFALVDFDTKVRRARRKLFRKTPLLENDRTLVPYVRKTMTINMDRAVEWFRIVIFNTKRKFYETLVEWDMRSGVIKVAIRRDCDRKCLYAVKISRLFKRDVREYSTERNIGQMLLNWFVSSIADNGNFKSLVSTQDLKNIGIQYCTHLLAAGVLRQISDKDAPTENVFKPNLMYYWAHMEAPVSQPVTPGRLHTSSWPPDKETNQMSRDITLYTAMDNNMFYSQNNNDETIDIQEAKAIIKQLKKKLQEAEYLLQKVKISNQIELLNRNLPNSFNSMQDSNLVKDKVELLVDKEVQTSMTLNEENKLTISPVISTTKYDSPIISNNNDVNTEEISRLVYKNQMGDAGDKCEKRSERIENYCKLNKSREYNKPLRKDDFLDNNNQIIDSDAVSLPDKSSDRQKYDTSSDSSFASTTSSKLTDEKSNHEHMWNKSETVVQNVSCLKNVATTNIIFSKVDQYVTSELSQSSLDQSQKSADEQSESSASYVNASTSEENCTQIETHSDIQIIPAIQDATLSSTELNHTSSSLPPPMPGKTPSPPPAPGTQSIAPELMTPAPYVNPAQSKSLPISITNLPSLSILSEESKSNYGEDSSRDLIASTVGTNIPISSTDASTSVSNTEITTPSTETGPQKSEELYCSSPEKRLSPPPEKCDTSLQSSKVGTISPPAISDEITTIMNIKTSKVPTSPCIPPPPPPPPPLPGMSPSPPIPGIAPPPPPMPDLVPSPPPMPGMGPPPPPMPGMVPPPPPMPGMGPPPPPLPGMGPPPPPMPGMGPPPPPMPGMMPPPPPMPGMMPPPPPMPGMEPPSHPSPGGGPPPPPMPGAGQSIGTIPPPLNASGPPAHQATGPLPFPAPPAGGWNMQRATLRKTPIKPAAPMKPLYWTRILAAPTQPAYQGDSESSKLKPLWLEIEEAKLDNIDEFTDLFSRQVVKAPAKKKTEVKAKIKPVKLLDSKRSQNVGILAQSLHVEFSEIENAIYNFDTSVVSLEALQQIYDLRATDEELMLIKDHLSNKPEIPLDKPESFLHDLSGIPNFAERISCFMFQAEFEDGVNTTMHKLDNLKHTCEFLTTSEPLKQLFAIILTLGNYMNGGNGQRGQADGFGLEILAKLKDVKSKHSQVTLLHFIVRTYMRARGGALSAACALPVPEPGDVARAAAIDFADVAAHLNELDKRLQDCREQTKKVLECDAQRNEDCVSSCGDNTKRLEVFKDKMKTFLDAAEEKLKTENDNLEECRAKFIGTVRFYQYTPKCGKIEECEPKEFFSLWTSFCSDFKDIFKKEEQIAIKEKLKENKKLQDERKSLTQPKKEGGLKARLQKLSGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R3B4</accession>
    <name>A0A194R3B4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_11554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R3B4"/>
    <dbReference type="STRING" id="76193.A0A194R3B4"/>
    <dbReference type="KEGG" id="pmac:106713756"/>
    <dbReference type="InParanoid" id="A0A194R3B4"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000338">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="301" mass="31737" checksum="249CBF2C597265AD" modified="2016-10-05" version="1">MSLNTAHADHGVLIHAGECIIIFSDNVTVEFYGNETPEFKGTKTGRMYLTTHRMIYNSKNTADAMRSFSFPFIALQDVAVEQPMFSANYIKGKVRAQPNGNFIGEVKFKLTFKSGGAIEFGQAMLKAAHLASRHAAPDAPPPPYMPPTAPWHAAPPPAYAPPPQGYYGWVPPYNAFPDQPPPNSVFVSNNPPPYPGVAGATYPAGPGFFGAGSPSGAPPGYPGAAGAAPPGYPGNATAPPGYPGGFSAPAPSTGMSSRDAKAAEAAQSAYYDPNQPQTAYVPPPYNDQPPTYQESTSKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R610</accession>
    <name>A0A194R610_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar and coiled-body phosphoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_14940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460883">
        <property type="protein sequence ID" value="KPJ11301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R610"/>
    <dbReference type="STRING" id="76193.A0A194R610"/>
    <dbReference type="InParanoid" id="A0A194R610"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="695"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ11301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="769" mass="82734" checksum="F76904F230959BB1" modified="2016-10-05" version="1">MDYPVNIKADAITLVSQYIQTVDKSLAQKFIEKSKLKPSPDKLPNLCEIIKEYIKLKKVSALKDLSRGAESSGVYSDEKSKKAVQVNGKAPAANKKKESSDSDSSEDEKQSKPNAKTVVPKPQAKKPQSSDDSDSSDDDATTKPKKQPVKPQQTNTQKVVKKQSSSDDSSDDDEKTKPQQNATVKPKATPAKPTTGKAQVTKKESSDSDDSSDDEKSKKPAPKQPVKAAPAKKQESSDDSDDSDDEKPKAPQKPIKTQVTPAKKPGKVETPKKQASSDDSDDSSDDDSKKLPKAAAKAQVTPAVKATPKKKASSSEDSDSSDDEKKPAQKQVKPAVAKQTPAKTPVKVETPKKQAASSEDSDDSSDDDTKKKPKVAPKLPATPAVKVAPKKQASSSEDSDSSDDNKKTAQKQAKPAVAKPLSKPTPVKKQKSSSEDSDSSEDEKTAKKPAPKAAQKPQTKKESSDDSDDSEDEAPKMLPKTPVKLATPAKAPTQESSEDDSSDDEAPKKTPAPTPKSKPAKKESSSEDSSDEEPQVKTSKKAAESSDDSDDDDGPPVKVAKKSKSENAQVLAECYYISFLLIPVTGCYNYRFLRLNMSSPFDEPQVKTSKKAAESSDDSDDDDDGPPVKVAKKSKSENAQATENGFQAGKKRKASGGDPTPAKKPYSNFVKGTKVVSTPSEKDNEGDSNANKTTPFRRVATEKVEVDPRLKDNSFEAKSGARGSWGERANLDLKHTRGKSFKHEKTKKKRGSYRGGAIDTGVHSIKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R6V6</accession>
    <name>A0A194R6V6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_06752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R6V6"/>
    <dbReference type="STRING" id="76193.A0A194R6V6"/>
    <dbReference type="InParanoid" id="A0A194R6V6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="413"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1200" mass="140508" checksum="E186BC2B1AF59A08" modified="2016-10-05" version="1">MENKENKSKKDKHDENEEYRREKRSKRARTRSRSRSRDREAKKDRDRDSRRKRRHSRSPDASDKRRNEASKVDEKKPPPEKKAKDTDMLNTRTGGAYIPPARLRMMQAQITDKSSMAYQRLAWEALKKSIHGHINKINVGNIGIIIKELLKENIVRGRGLLCRSVIQAQAASPTFTNVYAALVAAVNSRFPNIGELLLKRLVIQFKRGFKRNDKAICISSASFIAHLVNQRVAHEILALELLTLLVETPTDDSVEVAIAFLKECGQKLTEVSSKGVNAIFEMLRNILHEGQLDKRVQYMIEVMFQVWKDGFKDHPALIEELELVPEEEQFTHLLMLDDATDPQDILNVFKLDEKYEENEQKYKTLSKDILGSDAESGEEDGSGESGSDESGEDEEDEKKEMMIIDNTETNLVALRRTIYLTINSSLDFEECAHKLMKMQLKPGQEVELCHMFLDCCAEQRTYEKFYGLLAQRFCNINRMYIGPFEEIFKDSYSTAHRLDTNRLRNVSKFFAHLLFTDSISWEVMECVRLNEEDTTSSSRIYIKILFQELAEYMGLKKLNERLKDPTLQEAFSGLFPRDNPKNTRFSINFFTSIGLGGLTDELREHLKQMPKNVPAPITNITVDSSSSSSSSSSSSSDSSSSDSSSSDSSEEDTTNKKNKTEADKKKKSKGKKKQSSQPNEEEPKEKDKEAPERWGHDGFYDTNGQDARRMNSRPERSERDTFARPNGGSRRNDNRDDFRNGDTDGDDRRRSSRREDDKQDNYRRNRDENYERSRDREENRRERDHESDRRRNHKENDIRNGDRDSRSDRRYDNKETSRSDREDISFKRHNKDEEHRRYRESETDKRIQRDEGTDRRKQRQRDEVEADKDNRKERDGENTDKDKRRQRDRNDVDEAQRRERDRDDADRHKRKQRGEEESDRDKRKPRHEEESERSRTRQKRDENNYKDTEREREDQHTDRDKKKERNKEDTNRDNRKQRDNEYTDRDNRKQRNEDDTVTNKDSRKVSRSEKEKDYDKSYKRNEENIQSNRIEKNKDSQRSKETADTPCDRLNKNIKSKVTTVSKEESEKNKTNEEHKSRSKNEREKVKRNETKTKSKKRDVAAAAAAVVVAAVTAAVAVAKKKNPNEQTETKRRITKKASIKRIPEVRKVKTEKRLKIAVAVTVVAKVTMKKKKKKINWAADTGILLTLKPMPQLHPSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7K5</accession>
    <name>A0A194R7K5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460644">
        <property type="protein sequence ID" value="KPJ13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7K5"/>
    <dbReference type="InParanoid" id="A0A194R7K5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="208" mass="24794" checksum="874A5F449627DF1F" modified="2016-10-05" version="1">MTTRLKDLDSMINNYRTTMTNDYRDNAIEPVIKTVYQEKKPFIREKWKYVKYIHTMRDWDGERAPFDFTIPRKDIIRTNPHHIQPVYGKPKDLDLENVRKTRPRLVMTPAVSMDDLEDQDKRNLLMNSSYTTRMTTDYKPVTDVSNVVAPLLGKYSPASPLTIAKYKQPYVSPEWRMETTSWDQRQIRDYCDANKVFWLYTRPNRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R7N5</accession>
    <name>A0A194R7N5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460597">
        <property type="protein sequence ID" value="KPJ13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R7N5"/>
    <dbReference type="InParanoid" id="A0A194R7N5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16547" checksum="0B7472387E03AA32" modified="2016-10-05" version="1">MKANIVDIIVDPLGDKIPRFSEQHLNEILEWFEEKSQPISVPDVDEPINENRTFLDIDEIRVIATSVGQPFDEDETLELLRDANVRGDGNVYYEDFVESLFSLAPELYSIKAEYLFENPEEDPSQIESSDLEVPAQVQTKGKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R904</accession>
    <name>A0A194R904_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="10" type="ORF">RR48_11607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460779">
        <property type="protein sequence ID" value="KPJ12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R904"/>
    <dbReference type="FunCoup" id="A0A194R904">
        <property type="interactions" value="1070"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R904"/>
    <dbReference type="KEGG" id="pmac:106713786"/>
    <dbReference type="InParanoid" id="A0A194R904"/>
    <dbReference type="OMA" id="QYQRAKM"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="131" mass="15049" checksum="BACEFBEC334462D5" modified="2016-10-05" version="1">MSSPLENLETQLEMFIENVRQIRIIVSDFQPQGQSVLNQKIQSLVTGLQEVDKLKSQVHDIHVPTEVFDYIDQGRNPQLYTKDCIDKALAKNEEVKGKIDSYKRFKSHLLSELSKTFPNEIAKYKAIRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194R9P3</accession>
    <name>A0A194R9P3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_13624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460473">
        <property type="protein sequence ID" value="KPJ14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194R9P3"/>
    <dbReference type="FunCoup" id="A0A194R9P3">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194R9P3"/>
    <dbReference type="InParanoid" id="A0A194R9P3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="478" mass="54975" checksum="AC0B0529D2098C73" modified="2016-10-05" version="1">MHLRTIPSNSRESNLHAMVPRMELELALSLCPMNSAKSTSPFHPFLRNTRVVFRKYRIPPVASHPPYYNRRALNRDQQSPVRRSESALNSPTEPDVSLAASLTDPLEAHTLDEARRTIRDLRMKYRAQAHQLMTWRRAHRTQEELVTRLQREKAEQLKSLSSQLLLFESRLVRKQKEITNMLALRETIIMKQQKVIETLQSKLHENGIELAQQIPDFRDMLQDTHITGDFDSLNDSDSAVIMEDVDSDCSNLPLVPRFRSTNPDSVTVVRSISDAIDPNIKYSVVRRSNGFLRRPEILETVYSVEEEADGDSTKGLSAQNSTEKELKDMNKTDEQKYKETNSLLAQRRDNFRMRSVVLTAEVKSIDSDKDVPKPKAKEVWSYTYVPKRMMPANDSDEEVTSNADSDEGEQESRSNPVVTYNRVMSNHRNVTKPKDVKYKRINKAKSKSLEELRGRLKNWVEKGNKLSGIPLEHAQSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RB00</accession>
    <name>A0A194RB00_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Atrial natriuretic peptide-converting enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RR48_09055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Ya'a_city_454_Pm</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RB00"/>
    <dbReference type="FunCoup" id="A0A194RB00">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RB00"/>
    <dbReference type="KEGG" id="pmac:106710840"/>
    <dbReference type="InParanoid" id="A0A194RB00"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000235">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF146">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="10">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="241"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="566"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="254"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KPJ15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="795" mass="87919" checksum="FAF28EAE8D3422D7" modified="2016-10-05" version="1">MTFSGNMESKPRNAKESWESELGYGWTRSGQRRCRGHRPPESTMSVSSDIRFTRRKLSRPCRGCCAALAALLVLLLLAAVAVYLGHMYLFGDPLNRQTFRGSFVVTSWGETGEEENDLEVKNTTREYDLRQALHDAYSNSELRSCFVGAEILALDSADEGERVHFEVSFEPIFTAVGTPDVTDVMDRQLRSPTGYFSTITVLPDTLHIEESSVISSQALTESDSLEEEATTTEMISFELVEEVRECAPLTLPLCSHLPYNITTYPNLVAHPSKEVLMRDLVAFRELLDAECSHLAQDFVCQMLQPQCSDGRLVRPCRAYCRAFHAGCGARLPERLRAHFDCARFPDYFGPGSCAPEPDCNGGLRRLALSRRACDGVPDCADAAEERGCAHCTAAGQGALRCALHPRCLPQQHRCDGIPHCPDASDEAGCLWVSRSLASWKRETRESTLGARRSRGGYAVWAERGHTGKICAAPYEDDKKALMNVANSLCKVLTFTSAISADAVLDGEVEGEYKTDENKEQPEYVEVVDPSAAEISFVKSECPERRVLKVVCDQLECGLASARGREAGSGAAGLPRAARPGDWPWHAALLRANVHVCDGVLLHPNWLLTTASCFQGQPKAEWTARFGTVRIQSTSPWQQERRIIGLVRSPVEGSMLALVRLEEPVEMTDFVRPTCLPEGGMNNQSTCNSLGWTRNRDQLQRIHVVPTVMQSCENVSIATTNGICAEPLYDKDDCDEEEYAGSSMMCFDENSKRWSLAGVSGWRIACSKIGLGRPRIYDSVSSHVDWIQKTISNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCC5</accession>
    <name>A0A194RCC5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cullin-3-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_09146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460398">
        <property type="protein sequence ID" value="KPJ15119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCC5"/>
    <dbReference type="FunCoup" id="A0A194RCC5">
        <property type="interactions" value="2004"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCC5"/>
    <dbReference type="InParanoid" id="A0A194RCC5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000091">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="298"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ15119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="701" mass="80221" checksum="28E938FF8FCD05F4" modified="2016-10-05" version="1">MLKNTLPKDKPGKMRIRAFPMTMDEKYVESIWSLLKNAIQEIQKKNNSGLSFEELYRNAYTMVLHKHGERLYTGLKEVVTHHLENKVREDVLHSLHNGFLQTLNYAWTDHQTSMVMIRDILMYMDRVYVQQNDVDNVYNLGLIIFRDQVVRYGCIRDHLRQTLLELVARERRGEVVDRLAIRNACQMLMVLGINSRSVYEEDFEKPFLHQSAEFYRMESQKFLGENSAAVYIARVEARIGEEAERARHYLDETTEPRINLLDLKDRFDHFLHNSFNNDKLFKHMIAADFEYFLNLNNKSPEFLSLFIDGKLKKGEKGMSEQEIEAVLDKTMVLFRFLQEKDVFERYYKQHLAKRLLLNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFKDMTVSNTIMEEFKDHVLSAGTNLHGVDLSVRVLTTGFWPTQSATPKCNIPSAPRNAFDVFRSFYLAKHSGRQLSLQPQLGSADLHATFRAAGGAGAGAGAGSSAALAGGGGSPPHSPPAAPPAAAAAAAAPRKHIIQVSTFQMCVLLLFNKRERLTYEEILNETDIPEKDLVRALQSLAMGKPTQRVLIKHPKTKEIEAAHQFYVNDAFTSKLHRVKIQTVAAKGESEPERRETRNKVDEDRKHEIEAAIVRIMKARKRMAHTLLVAEVTEQLRARFLPSPVVIKKRIEGLIEREYLARTPDDRKVYTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RCV1</accession>
    <name>A0A194RCV1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="12">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RR48_10920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Ya'a_city_454_Pm</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="KQ460615">
        <property type="protein sequence ID" value="KPJ13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RCV1"/>
    <dbReference type="FunCoup" id="A0A194RCV1">
        <property type="interactions" value="1302"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RCV1"/>
    <dbReference type="KEGG" id="pmac:106712348"/>
    <dbReference type="InParanoid" id="A0A194RCV1"/>
    <dbReference type="OMA" id="YHIIMVT"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KPJ13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="133" mass="14121" checksum="58B6B9A5E2FD0F3D" modified="2016-10-05" version="1">MPPKKQPEKQAKGGGKSSGGKSGGDAKESAAKEKKGGTAVKVRHILCEKQSKCLEALEKLKAGQKFPDVAAAYSEDKARQGGDLGWMTRGSMVGPFQDAAFALPISSVTNPIYTDPPVKTKFGYHIIMVEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD16</accession>
    <name>A0A194RD16_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 4C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_09651</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD16"/>
    <dbReference type="STRING" id="76193.A0A194RD16"/>
    <dbReference type="InParanoid" id="A0A194RD16"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ15728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="445" mass="52563" checksum="010DFEA12C8F5292" modified="2016-10-05" version="1">MPKRLMRAMAIFARLCPDAILSRRQSEQYDNNNIKLLSSNRFTKKYLPYTFLAPWLSQGLVLSNGEKWRKRRKLLTTAFHFNILKQFVQTFVHESEFFIDELDKEEIGKEKTDLHPLLSWTLQKVMFATAFGITKHEDLKSVTKIYFDSVLSFCNTATYRATRPLLYPDIIFNLTKTGKQQRKDIEHLHELTHRIIHERKEFIRNNNLVKNNDYEIMGQKTRSTVLDLLLEKEKEGEIYYDGIREEVDTFTFGGHDTCAVAHNFLIMRIANDPRVQDLIYEEQQRIFGDSCRPLTIEDLNEMKYLECCIKESLRLHPSVPLIARYITEDVILSGHTVPANSNILIHIYDLHRRQEIYPEPEKFIPERFLPENSINRHPYTYIPFSAGPRNCIGQKMAMLEMKTYMSGLMRRFRLQPVTRPEDLVYKLDVMLRTTKPIYVKLLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RD97</accession>
    <name>A0A194RD97_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_09373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460367">
        <property type="protein sequence ID" value="KPJ15444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RD97"/>
    <dbReference type="InParanoid" id="A0A194RD97"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ15444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="305" mass="33849" checksum="17300E38E1B67A53" modified="2016-10-05" version="1">MNKIQIEMESYAAQSCLYDEQSGRADSVDGAGYIENAKEKGFMSTCRYITLKKTRSARSDNIFDIRARRDRAIGYRFRLVPIIVVKNKERGRIADSPKFMTYIAWDRSSRCACSTARYSPESTLNTVLNLITKEKHCAARKHLMWALALPTCGGTTHFRAWHVHLGSQLGTDCCARAASAASATDPFTTDPRALQASSSRCTRQTANITLNSLGKFAQFSRKRSERKLDETHIGGLSNETAAKVNGSSRSMSSERIHHKVSRRVVGRDEVSRGARVRGSSIVACSGRGQVTWRRPPDAARPDALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RDU1</accession>
    <name>A0A194RDU1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DET1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460325">
        <property type="protein sequence ID" value="KPJ15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RDU1"/>
    <dbReference type="FunCoup" id="A0A194RDU1">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RDU1"/>
    <dbReference type="InParanoid" id="A0A194RDU1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="958" mass="109627" checksum="A061F15EDDEA8E28" modified="2016-10-05" version="1">MASVYYEDAPPGSLNEDEFFCTERIVPRKIKPQNIVIRLMDREIYGSRKPGSHFHVVREFYQNVFPNLTIVNVEKPPCFLRKFSPDGKHFIAFSADQTSLEIYEYRGASAAGDLVAGYPADLLNADADVHHRIRTHIFYRFFKPKFTVNVCQQRLVSRSERNPGQLPFIEQQLNRECSLFTEDGRYVIVGSAAHIPDDLRPHFYHIHSNNEAVTPTIRSALEDYSLHLVDLHQGKLCDTKHFRIDKIYLSHNQGIYLYKEVLAVLSVQHQTIHLFQIVDGMLIEIRKIGRFCFDDDPFIVNSVFTPQTNERPFHEETINSLKHRLLVFLFKRAKSISDSTNDPFELRKFYKYFDMFKSLRMWKMQLLDEDHLFIKYASEEVVTLRVAEPNSQSSFFVIYNISGSKILAVYENTSEALLQLFENYCDCFRNARLCADSQFTCSPSNNLYARLTQQRFKQTIVRAIYGGRTEATKRILAQLPISAQSYSGSPYLDLGLFSYDDKWVSVMERPKAYGEYPIRFYARDSGLLKFKIYAGVIGQSVPASARRLVAFTFHPTDPFAISSNVQSPEIIGEGDVTSVVLPNGSVQYFFIPTIKRDVWTPCAYAPPTMNVNWNIPSQAWFIRNISNPITPSFCSGQQYLRPYGEPFIANIMPTDCNTNTPALGYTNMFHYDRCTSTSDLQYFYPRVLSRHQQTTDVKVKSVRKPICLFDLACDKPCPCGVVSGTKYCQDESEKEPEHVSSAMSIEGVERKVSCECPPKDKSLGKSVITLRDSSFEEDSEEITVAEKNKIHESSKMKSLEKEKNNSTSKSKAKNFKIGRKTSPVEINTKDTPNSKNLRKSRYYKLEKSEESSSSEKEKVGTDEPKPKKQVKDEKEKKKREKCQCEEDSDSDSKPAEKEEKRSCCCTRKRYKGVASYKDKEKAENRLSLIEIVGHCDGSCCCSQCAANGAPQPPTKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RE62</accession>
    <name>A0A194RE62_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RR48_06966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Ya'a_city_454_Pm</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460500">
        <property type="protein sequence ID" value="KPJ14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RE62"/>
    <dbReference type="FunCoup" id="A0A194RE62">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A194RE62"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KPJ14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1117" mass="131881" checksum="434A5E18923AB278" modified="2016-10-05" version="1">MENIGAALVVTGRDAGNERRAAFRNNIKMIIESCTACPFKYRKGTYLCFFCKTSFLEPERLREHTRHQHSDVKQLLKPRKYEPLKMDFALTTCKLCGLSISDYEMLKSHLREHGKHLDCSYGDSILPYNLTKDDHRCQICGKRYEMFLSLHKHMNEHYEHFICETCGKRFATSQRMVNHARTHERGDFPCKRCQDTFPSYASLYAHVAKIHRSNKRYKCPICDEKFASYKHRLKHLNTIHGEKTAIFPCPSCPRVFDLCSRRTAHIRFQHLQERNHSCPLCFMKFFTKYELQEHSIKHGGERIYQCDVCKKSYARLKTLREHMRIHNNDRRFVCPVCGQAFIQNCSLKQHVRVHHSSSESPCEDQQDKNNTGLQRKKRRNIILNPEILKERKKNSTLILEAAKLCPFRWMKNLFICFYCDQQFLDPDALREHNNLEHSTPSLSQIEHEMSKQKKHEFVKVELTNVSCKICNQILHDIPSLKYHLMDRHDMYINSNDGILPFKISKDNFVCILCSTKFETFKSLNHHMNVHFQNYICEQCGSGFITPDRLRAHSVIHVNGSFPCEECHKVFRSNTARTEHIANIHKKCKRHRCPECHEGFRNYFQRNKHISSVHGMTLKEFKCDLCPRVFNLSGKLRVHFRTVHLKMKRYTCEVCDWKFYSKSELKFHMIKHGGERKYQCNVCKKAYARKYTLTEHMRIHDNDRRYSCGECGRSFVQNCRSDSTDIQATKRIVPLFQVDYDRSLCRPLGTVTNFKKVLAMAQLSGEDLSSRSPSPIYMDRAPSPQIVHDRIDIPQLQEQIPQKNIDIRQNALTLFEFSTVYPFVYGNNKFKCFICSQPFLETSLLKRHMQDTHTYAPIKRLVNNRRENVIKVDVSEMGCKLCPHKPKDLQELKVHLKVEHHKLIEPDLKDNIIPFVLEGDEEGYKCVMCESKFIKVRTLVIHMSVHFNNYSCEICGSGFMTLRLLKKHLEVHESGNFHCDRCNKVFNTSHKLSLHIRGVHLKQYPRRCPICPERFNSNYRRTKHLQDVHNQSTRVHKCKTCGRGFNLRYHLVCHTRSVHLQERNHQCKICLQRFCNKETLKRHMVIHTGEKNYKCEMCGEAFLRRKNLRDHLRVHEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGS5</accession>
    <name>A0A194RGS5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidate phosphatase LPIN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_10243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460207">
        <property type="protein sequence ID" value="KPJ16644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGS5"/>
    <dbReference type="STRING" id="76193.A0A194RGS5"/>
    <dbReference type="InParanoid" id="A0A194RGS5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipin N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="334" mass="36874" checksum="246DACEA0A73F0A7" modified="2016-10-05" version="1">MYSMNYIGKFIANFRDFYNEINSATLTGAIDVVVVEQPDGSFTCSPFHVRFGKLGVLRSRFKVVDLELNGEQLNIHMKLGESGEAFFVEEVGEDEAECSAHLATSPIPASRFDDLYEPRRRNSLSAVEPDHGQASDYTKRRYTADGQTMQKPNLSKLKTIDVQETKNDNENEALFEMDGLDEVSVDWVDAKPKTFAATKLGEAQSEANQVVQKISANNDFRPIDAAPANQEEVKQNGNGKKKKKTRKVSAKKKHQRKSSTSSVSSQSDLASSEPRSSQPASIQNNADINFFSDTEANAAALSEEMSNLKLNGDNRIPLALSDTAFEVHAASRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RGY7</accession>
    <name>A0A194RGY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemicentin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_13939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RGY7"/>
    <dbReference type="STRING" id="76193.A0A194RGY7"/>
    <dbReference type="InParanoid" id="A0A194RGY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265189" evidence="5">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="422"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="512"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="640" mass="72495" checksum="CCC381973E53D7A2" modified="2016-10-05" version="1">MVEKLYHSIVALYILICSVYCQEGANSSLIFVIDNTVSMSKEIKSVRGCADAIFNTVVSSNESGIVDFVIVTFNDPGFELRVITNNKEEFNSSLFNIKAGGGGDCPENAMSGIELGLKSSRPFSHLFVFTDATAKDMEKYEVVKNLALNLNIKINFIVTEYQPCYTNYSVFSPYETLATKTGGEFFVMKKHKIPEIIEYVKRLIESNKVVILSKRFRPEEEKKVDVTLDSGIKDALVAVTGGDNSTIHVKDKFNATVPVKGIADTKKSKIVAWNNTEPGDYHIELNKTDNKTNTLLIIHGTSKITFSYGFSALKPEYMNETTNRPVPDEKSYILIKLKTKAKKIHLQKIQVVDLKDKVLLDKSMNIIEKYQLYISEPIVFPKDTFKIVMIAEDEETKETIKRTSLPIESQKVLPGTIKDEAPKVYITGNPKMILSYESPLQLTCKVTGHPKPKIFWTDDFGSTLTFTVTTIKVDYQFVSVLDVDIVNKNNTYICKASNSKGSDEKSVKVEIPYYFDVINLSKDKKVEYNKEEKLYCNVKAIPPANVTWYLNGKEVVTDDNLSISSDQMTLHIREMKPKYVGNFLCEIRNNMKRLVHNIQLTITGVEEDKSTSSEEERPRPPRPRSPRPRRHGEILLDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHR2</accession>
    <name>A0A194RHR2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_13721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHR2"/>
    <dbReference type="InParanoid" id="A0A194RHR2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ16865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="72" mass="7634" checksum="3ADA4659850EAA11" modified="2016-10-05" version="1">MSQLGSMSAIAALLHGADGLHHVDDEGGAVLSAAAATLERRLPVTAITIVVRILKYSNKWYVIFEAAVTGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RHT3</accession>
    <name>A0A194RHT3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_08574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460152">
        <property type="protein sequence ID" value="KPJ17388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RHT3"/>
    <dbReference type="InParanoid" id="A0A194RHT3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="356" mass="38933" checksum="A72F803E9F85E1B5" modified="2016-10-05" version="1">MTSVESSTIVLHEERKRFVSNRSEYNVDLWREFKKRWMVFGVLGAVALAVISPRLGAPGGNYPACKLRMEVVRCCALWSLYYITGRSTGLRGENGVHKIRVRLYVLSVLHAQVIAPILAAVSALALRDASLDRRLLEGALVARSRGPCGWLSLALCCDSSPTTPVLAALNYAVSLLAAPLAILFFCGRTALPPLGGIVWTVVTTATPFLIGCWRSQRLSPRTPRTITRLLALLLLYIDCSALLREAEGSLYITDVLATLFLEMSSVSLAAAGSSLYAHYGWLRRTESRALALAAVPKAVGLGWEMQVSCMSSGLAHLPTVFLAPTQALLMAALYGNDKEYQFDDELTFENLPLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RI81</accession>
    <name>A0A194RI81_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RR48_13891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Ya'a_city_454_Pm</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ17035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RI81"/>
    <dbReference type="FunCoup" id="A0A194RI81">
        <property type="interactions" value="1565"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RI81"/>
    <dbReference type="InParanoid" id="A0A194RI81"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KPJ17035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="802" mass="92454" checksum="B66BE5A83FE225DA" modified="2016-10-05" version="1">MPAPPPQTGPMPGDNQPNVAYQRVSVHGMHASGVPLEDLERSASLLTEALNGRRHYMALAGQSFQPDLGHVLASIDTNAPRYHISMNFSKILKEWDYDAAETYLPKEETSEDLSFPFNVQSRVSHNRSNTGNDAAETYLPKEETSEDLSFPFNVQSRVSHNRSNTGMPVIDELESEAITKLPESSRSSESQDRIPTEPTQEEMDSWACFTPPNKHYVFRWCEGVLRVYRNETDAEAAQPLPYECVSFTKYVEDLDKLCEMITDGPLSSFCFRRLCYLFSKFKMHVLLNEIHEQALQKAVPHRDFYNIRKVDTHIHAASCMNQKHLLRFMKRALRQRPSEVVAKTGARTLKSVFEEMRLDAHDLNVDLLDVHADRNTFHRFDKFNAKYNPIGESRLREVFLKTDNYMNGLYFASIIKEVIGDLSEGKYTYVEPRLSIYCKRMDEWARLASWALRHGVRSPHVRWLVQVPRLYDIYRNKKLLKNFQEFLSNMFEPLFEVSINPSSNLELHQFLTQVIGFDSVDDESKPENPHPQECMRRPTEWCDEENPPYAYYLYYMYANMTVLNHIRREQGMNTFVLRPHCGEAGPVAHLAVGFLLAENISHGLMLRKFPVMQYLYYLAQIYIAMSPLSNNSLFLRYHRNPLPEYFARGLRVTLSTDDPLQFHFTKEPLIEEYSIAAQAWKLSSCDMCELARNSVLMSGFPHEMKQRWVGEHYQRSGAAGNDITRTNVPDVRVAYRHETLLDELRNLFGKPVTCLSALCSSCGDMRRCARSSILKLAKPELNECSADEYPNNSDNGAMHSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RIV9</accession>
    <name>A0A194RIV9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate receptor-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_09922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460323">
        <property type="protein sequence ID" value="KPJ15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RIV9"/>
    <dbReference type="FunCoup" id="A0A194RIV9">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RIV9"/>
    <dbReference type="InParanoid" id="A0A194RIV9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="414"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="509"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="662"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1105" mass="120720" checksum="4466CB3F30C93E70" modified="2016-10-05" version="1">MPNYASQNSLYITTKLAEVPVEKVNGSLGVTIRGGLPENSAQSADLVLNSRSLDALPLVVTHVRPGGAAYHTSRIKPGDRLLKVDHISLTNKTLSEVHQILQNCPQVTSLTIEYDVSIMESVKLATGPLLIEIERPCNEDLGLFLTNHRYSDDVYSSGSDTYQRVGTCNAIYIDSILPASISDRCGALHPGDQLLAFDDHVIEGNNYTAEEVMCYLESCEAGFTRLHLAPRHVLAHGGRFTGTRENSISGSSTLNTKKRQRNYRQSSMPKLGSPEDYGNYNYLHKNTRKECINVVLYTNSNSICGALHPGDQLLAFDDHVIEGNNYTAEEVMCYLESCEAGFTRLHVAPRHVLAHGGRFTGTRENSMSGSSTLNTKKRQRNYRQSSMPKLGSPEDYDNQQSYMNVGVCRTESLSVQLEVPPGHCSGLALHDDNSQLIISHVQPHSPAYRSGCLQTRDRVMSINGHENLTLDVANEILQRRNDSHNPKYLTLNVEFSMPNTIEASSGVFNVKLTKTSAGLGVTITGCKQKLLSNEEPMMISDIKAGSVAHRSGALAAGDQLLAINGQPLHNLSLDTAFNILQNSPDDIITLKIRKRDLTEDWANVHKHNPKLSLQSFSNIETKAMIHSGEDSGHHTDSPNNSAKDSERSHGSCSEGGNAAVFVVELIRQENGPLGLTIAGSEDVTQPILLSGLVEGGLAEKCGKLAIGDELLSINGESVLNKPLSEAIKLLQQSGMRVQLQLCRKLTGPLESGETSARDSSHSTSSPGLSNDSAVESWDQNTPIRTSANCGNSEVIEYAVPDKSRIIDKQPYSPTDEDKLMASSFSSAAPYGVSDLPLPNYSLNNSLKTFHYENTCIIPDNTLKNKQNITREDDVHQIEILTTNMKDCQLHNMEKSSCKCDYVQMGPYGVVSPRSRRPNWDGDYLSGSGGGIYTVTTPQKSPLKASATASSFQFSTSPIYENDVPGLYSSETLSPARGSVHQVILYKDAIYDDYGFSVSDGLYERGVYINRIRKGGPADIVGLLRPYDRILQVNGTRTVDYDCCLTVPLIAAAGDRLEIVVQRLVTSKIYIEIAQQSCRSAGEEIHGQCELSGMNNSSGPNLIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJ35</accession>
    <name>A0A194RJ35_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pseudouridine-5'-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_06644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJ35"/>
    <dbReference type="FunCoup" id="A0A194RJ35">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RJ35"/>
    <dbReference type="KEGG" id="pmac:106707833"/>
    <dbReference type="InParanoid" id="A0A194RJ35"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ17838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="247" mass="27821" checksum="394C1894B3CFD831" modified="2016-10-05" version="1">MRIYLLQNLSKTIGRRFLATHNVRKVTHCIFDMDGLLLDTEQVYKKMITQLCANYGHKYTDELMMKVLGGTEQRLSEILCKELKLPVAPHEFRDQLLKLGDTMLAGTPLLDGAERLIRHLHKTQVPFALATSSSERSVQTKIASHKELFSLFNHMVMGSSDKEVKFGKPHPDIFLVAASRFLDKPDPSKCLVFEDSPHGVTAGIEAGMQVVMVPDPHLDKRLTKHATIVLPTLAKFQPEMFGLPAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RJG0</accession>
    <name>A0A194RJG0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_07365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460075">
        <property type="protein sequence ID" value="KPJ17968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RJG0"/>
    <dbReference type="KEGG" id="pmac:106707691"/>
    <dbReference type="InParanoid" id="A0A194RJG0"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ17968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="286" mass="33538" checksum="193609DB2BFE6560" modified="2016-10-05" version="1">MKKTSSLVWRFFDRLEENKRCVAVLCKLCDTQYKYFGNTTNLRTHLVNKHPIQWELLQNGTLEESTFRTFDDDENTNQTVAPKRRKYLKVDVLEHSEADIDNNDEVDTTMNEHERQNSDEEWLEDEWIETYEPKRNKLKYRRVKREVTTPTSPKSVRSYAFNRKPPTFKTNTHPRLSAVTTEVRKDEYAVFGEYIGNKLRKFKSYQTSVNVQQLITTILWQAEYGVYDNIESVKRIVLSTVQQMDTVHNTSTNNENIQVSAEGIVIDKDPDNIVQSVIDSVRVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RK29</accession>
    <name>A0A194RK29_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_12036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RK29"/>
    <dbReference type="InParanoid" id="A0A194RK29"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="102" mass="11276" checksum="C886012F90B71313" modified="2016-10-05" version="1">MLIVEAPGEVGAPPALAPLHLPMMTLTKLNFTDYSAKVNKQYNESEQRDNRGYDSALAARLSYEQSVCGAAKLNYNESNRLAFDQTFDNINTDPAFLLPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RKR8</accession>
    <name>A0A194RKR8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_11867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RKR8"/>
    <dbReference type="FunCoup" id="A0A194RKR8">
        <property type="interactions" value="1334"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RKR8"/>
    <dbReference type="KEGG" id="pmac:106721575"/>
    <dbReference type="InParanoid" id="A0A194RKR8"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="238" mass="28275" checksum="F0C6AC4F5B9CB5F5" modified="2016-10-05" version="1">MSSDAEENNLEENDSERIAIKNELSSLSFEDLQKLKERIGAKLYKEVVFGKKNNPETSPKAKFFKRENKNRPREMSSKRPVRMLRDTGKVKKTEIRDPRFDPLCGEFDKKEFAENYNFLSDMRYEDIKSIRAELKQTTDPEKVLKLKRLLQSLNEQHRASRKARVQREKVEKQKKDVEKVFREGKQPYFKNKSELRVETLVNQYEELKKEGTGRIQRHLKRRQQKIKKRSNKAPVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RL89</accession>
    <name>A0A194RL89_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RR48_11933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Ya'a_city_454_Pm</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RL89"/>
    <dbReference type="STRING" id="76193.A0A194RL89"/>
    <dbReference type="KEGG" id="pmac:106721502"/>
    <dbReference type="InParanoid" id="A0A194RL89"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="13">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="425"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="538"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="633"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KPJ18085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="891" mass="102317" checksum="3C05A9508BDC0521" modified="2016-10-05" version="1">MFCNVCGVVDDYYDEDALVDHNNTPKHICNKILEAYREKKRNFAKNRDGVIILGRGESAAIFGAEKTKVENTDHQKIRMNAKPTQPVKFSFTISNDMRNEDLLIVGIQLAHPQPQFLISDHPYIFGGEPNILEKKTTKKNIVFVTFAASEIGTYEMPIMFTFHRRSDEKNIIIIREMVVSVFEEESVHMFTRSPYTNEDWETADQIIPSIGLSPYPVKFKVPRLLKILLPHGLEEKALENIRAPREIMEQLRLVLISTRAIFDEGLTKSNYMAFFHHLLWWEEVKARINLRKYNMFSVMMEQRNGAYILEVPGLAEKRPSLLRGDRVYIKPQDTPKLNFECTIKDIELNRIVLTDLDETFEPHYKADALFDVRFLMSRVPAERMHEAVNSIHLSKQLCRVFPDRPKRQVSPALITKFYNKWIQNNKEQRSAVEHIVAGTSGRAPYIVFGPPGTGKTMTIVEAIIQLVVRNSRNRIMVCTDSNMAADHIALMLLRYNKQLNISNFLLRGCSQSREWSVMPQELARVSNGVSYETFYSLSNAHVSQYRVFVTTLLHAAKYGMEKCQAIFKLQMTHLFIDEAAQASEPATLVPVTGLLAPTGHLVLAGDPQQLGPVCISREAKDRGLGVSLLQRLRTTFENFYSDDPNFITMLVKNFRSHPDILAIPNELFYENNLQALAQFDPISEKSILNLPGGNRAVIFHAVNSKEQRMGKAPSFYNEKELDMLKKYVRALVDVHNVQHKDIGIIAPYIRQVYKMKEWLTASNYSEIEVGTVESFQGKEKRVILVSTVRANCRLLDYDAKYGLGFLVDDKRYNVTLTRAKAKLIIIGNPACLTRDVKWRKYMGFCNELNCYHGKENQQLERSSQMLVEIARTRFDRARISDELKQKNQSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLP4</accession>
    <name>A0A194RLP4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RR48_10702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Ya'a_city_454_Pm</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DRC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLP4"/>
    <dbReference type="FunCoup" id="A0A194RLP4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RLP4"/>
    <dbReference type="KEGG" id="pmac:106720969"/>
    <dbReference type="InParanoid" id="A0A194RLP4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="6">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KPJ18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="818" mass="93994" checksum="9C9C4793703A1826" modified="2016-10-05" version="1">MAGNFRGFDDEEDVLAPKEPQVTSQDPNERKAGRALRIKRRQEALKRAEQAAEEVRAEEEPGPIEQATATAAEELQRLTLDGAAKVTNVRVTTDEREVLRRELFSEKMKNALEKIEEEAAEAQIQYDAITSNWDAMLKIKDPLDIDLEISEQRKKCDALLEQKNKLIEDLKLELKRTDEAYYEDLDKQDKEIKELSDRIEKQVTIMQRAYEKQLSLIEQAINMERDAMVEHNNKRWEALYKQRDKEELVHMDYKYEQLEEHKKEVEAIMWDHHTKYREARIELENLIQELQKEQEKLKTTCLINTEKIGYNYQVLKKREEENVFVRSQQKRKLNKMSDVANSLRAKIRKAAEDGAIEEMKADAEIIKLMQAMDDLEKKCRHFSKVNNYKFTQVWRMSESQCAQLSRDIRNTEVALHAHILAEPPPPPPPKFPKNPLIKYEYEGPPIVRRETKEDSANAVTKDAKDKLIQHILKLVSDNTGFLVEDRLLKLIEKHQPSSRNLCTLDSIFMALEIQAEEDIELLCKTFLNYAFCPICVGMEFGTMSDSLEQLSGVSIPVKDESHPSVYKGSRVERSSTKVRSSVIARSVSASTSRSIHVGFKSHELSSEERELMQEADEIIQKCGEQQGSSTATGITSETGASAPGRRAGRGVTVSSFQTLAMDKDHPFLCPVGHLLEIEPMQVLTALNEFMSVFVPPDRKILNDILDSVTPPDFTTPSRRLTPDEIEQYWSQCKNVFSPEKDRFWEGLLAGLNSYLPILQERERLHEEVVELRDRNAALRRLVRGALPELPAPRRRNQRRVFTATMPDLAPSPAFPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RLT5</accession>
    <name>A0A194RLT5_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_13802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KQ460205">
        <property type="protein sequence ID" value="KPJ16946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RLT5"/>
    <dbReference type="STRING" id="76193.A0A194RLT5"/>
    <dbReference type="InParanoid" id="A0A194RLT5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ16946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="266" mass="30055" checksum="E605FD2AF9713E72" modified="2016-10-05" version="1">MSSTTSPKSSLAKLVLYPKQKPFKVMVLGQSGESEYANLESNIRWAEAFILMYSVTDKCSFDECHRLKFLINYNKRRRRLSATKDSVLETPVVLVGNKTDQIGDRMVTTEEGQRRSKEIGCVCFHEISVRESIDQVWGVFRDARRFWRVGSKWTRGRGDARVSTALARPLARAASDSAPEPPTTPFCRRWTEVDLEEEHEMGVVRSDSTSSSGLSEGVEEFRARASTDSRLPPRPARPRHPVPTRPMAPPVRRMSVSMKGNNASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RND5</accession>
    <name>A0A194RND5_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative malate dehydrogenase 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_12533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RND5"/>
    <dbReference type="STRING" id="76193.A0A194RND5"/>
    <dbReference type="InParanoid" id="A0A194RND5"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ19022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="614" mass="69574" checksum="B5035BAE49C89B44" modified="2016-10-05" version="1">MGVQIIISGESQCESFAKICAIADYLSQNLPNFCYRIIEKSVIEWKTWLCKINLRNKWHHNESPLIWKELLIEGSKPYYIGGASEFLDYCYSYYQFETYISCDRFEGLIENFNQYKKKIKKGVNIDDHESKRAAEDSAKNITVCISGASHPLTMYIISGLLDMPLGHKSIAKIFIYDKEYSQTFLEYVETECSYVGNNYPGKVVKYTNKMGMALASCDLLIIMDYVPFSLDLSIGDWLALNARCLKTLAPMINASASRNMYIVLPNLGPACYNATLLTKILTSINKKNIVVVTSDLGLELAPIAAEVAEVEMKNMFCPPVWGFVGINHLVDIRNTIHKYNAFQPYNRYVKVRKSSLCVGVLTPEFRTLEYLLHFNENLWTKLLEAKKKANNEELSINKAIALLKFVQVWLSGPNSDDILCLGVVCNGSFGLSFDGVFSQPVKFTDGFWQPAFDYLVPKDPHLNILYLEEITKKIIVVMWLWDMWGVLWVVQAVAQLIAVLGTPLEPALNLRGERNLAASAVISPLVNIALHFVVKNQFIWLRNYGGKSLQIAWRDDNLAIGEALDRDALPSSARQSPLRDGDEVRGAICNDVEKFTFADSFSSLVDLKRKMYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RP23</accession>
    <name>A0A194RP23_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_06577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460106">
        <property type="protein sequence ID" value="KPJ17771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RP23"/>
    <dbReference type="InParanoid" id="A0A194RP23"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1349"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1394"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
            <begin position="1518"/>
            <end position="1529"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ17771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="172626" checksum="9E456DDA05C7E156" modified="2016-10-05" version="1">MLGGGNLVRCERYRKTPRTPRSCHARYYYTRSLVLDTRNRPRQQRLRCQSAPKVMDRSHSRSASPREPARPQHRPPSPPSPPAAFDNRAYEHDDYDPNHNDFDSTGPNQNGHTKEVNGDTKTLEAVNLELINLTPKNGTTKQRKDVEVDMNTSNPYDEYFVPVNEHRKYMRGEKLYVTADKRGEKGGCKRPLCWTLLGLVVATIIALIVLAATGILFTNSPTPLEPYNASISSARALGGISNAMSNEQSHEHDRDHETDQGQDENHSHVHGHDHGNNEQNSESEQYGENDQTTEHGNNQDQDNSPEDMSRENQEILRTQYRTTPPSIDQGPQMQNDDSINPSSASEETGDKSIYVPRTLEGELKIDNDDFTAALEDPESDGYRDFVNAFGHALKQVLFNKNSNINKLEYNENDIALEIVKIRRGSIIVTYRIHWNPKHNTQTSDNLLTPNTLKESLDLYLAQNNRMISIYHIAEDDMATRRILDICQINKNDCDYGCQFDKRTLDFTCTCPPGQIIDMKQPKKCMLLFDNQDQINNNFTSDLSTTTVNPNPEDRKSNTDIIYSKQTATPLSEATTENDSDVNFSHIFGSSVNENEKHVTEKYQPEEHNNIATQYISFLETTQGPTTDNAMMEKNNEPVAEPEPTSEPQHEVKTTVTSYSFDHTTPNKDMQPTPTLMPEDHGRSSEPQPTPEPTTETFLYQTTETKTFSEENPNFIESNKMIKNKDLSNSDHLSTTETASSFTHYTNMHDNKFHMTTMIPSEIDTTQTEMMSEKYAQETTTEDEWLDDSSEKVSKSDKSSTEQVIYEKSSKSYESIYEISPTTLQDTEKEIESYTKSGIAKEIINEADHTTNAVSISQFLGKKPSEETTANSLLDTTVSVLTGIEESRHFFNNETTENNISGETTPSQISLFGITSGRPMIYEHADATTSAFETSTEYSIAKQTKDVNVVDPNFMTILKNTNNTEFDKNMNFNVTTEKDFAEGDIIFDAINKLYNRSSKSFVNDKESVAIGTEANYMFKETTETTTSADWLSETVTEINYQDIIDENKNKLTTETSATKVDEIMSRGLNKDDFEPDYLNMGSNTTKNIEHDMPQYGMLHDYDNDDMVVKRVKNAPVSMIEETTAMNVVQIASKENQMDELTPIPTVETNDTFETTTVSDYIYKMLNNSNENLSSVVSTTQPVPQVWENSEDDMNFIRHLATSMVTDDVSDITTTLATTTQDNIDKSNNENMINISESNIQSSNTSQANNLNVNIYEISNPPDNHTTEKSVNHQPIEFVDHETEMNPFLPEIENNKSLVKKLQEGHDLEPSNVNETQNETTEDQLHRVSDENITVNNQTDSNGPTPTTTENTTLKAEDNEAILKEMLMQQDISSNEEKSRTSLGERNNNAETTTSVDSLVDDAKDLSVRNDAVPLTTFLLDTDDLDTTKDPFEKETVKSGLVGNYDTTMMSITLPETTATTTDNKIKINYNNDILSVVPIEPEVINDQDNLKKNYDGENIAELNQISDSPKKSDRRTVDSDNTNSLIYNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RPY1</accession>
    <name>A0A194RPY1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Na(+)/K(+)-exchanging ATPase</fullName>
            <ecNumber evidence="20">7.2.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">RR48_11929</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">Ya'a_city_454_Pm</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.13" evidence="20"/>
    <dbReference type="EMBL" id="KQ460045">
        <property type="protein sequence ID" value="KPJ18081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RPY1"/>
    <dbReference type="FunCoup" id="A0A194RPY1">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RPY1"/>
    <dbReference type="InParanoid" id="A0A194RPY1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1108"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KPJ18081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130616" checksum="F995D542AF3F7B99" modified="2016-10-05" version="1">MGEHGRSDSYRVATVAPVKDDNRTADGQYKTRRKPPAKKRKPGDLDDLKQELDIDYHKVTPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFALLLWIGAILCFIAYGIQASTVEEPADDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDIVEVKFGDRIPADIRIIEARGFKVDNSSLTGESEPQSRGPEFTNENPLETKNLAFFSTNAVEGTAKGIVICCGDNTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFLIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALAKIATLCNRAEFKGGQDGVPILKKEVAGDASEAALLKCMELALGDVMSIRKRNKKVCEIPFNSTNKYQVSIHESDDPSDPRHLLVMKGAPERILERCSTIFIGGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDLQLPSDKYPIGYKFNTDDPNFPLENLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSEVNPREAKAAVVHGTELRELNSDQLDEILKFHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAIALAYEAAEADIMKRPPRNPFCDKLVNERSLCVFTVCACSVNGICCVFDVVHIVPAISLAYEEAESDIMKRQPRNPFTDKLVNERVASRRVCDFEAFVAERCVFVCIRLERRLPIMNVGVRVCGFAIGFVICADCLVLPKVPAISLAYEAPESDIMKRQPRDPYRDNLVNRRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPLKLFGIRKQWDSKAINDLTDSYGQEWTYRDRKALEFTCHTAFFVSIVVVQWADLIICKTRRNSIVHQGMRNWALNFGLIFETALAAFLSYTPGMDKGLRMYPLKFVWWLPAIPFMLSIFIYDEIRRFYLRRNPGGWLEQETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQ74</accession>
    <name>A0A194RQ74_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and SOCS box protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_07483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459765">
        <property type="protein sequence ID" value="KPJ20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQ74"/>
    <dbReference type="STRING" id="76193.A0A194RQ74"/>
    <dbReference type="InParanoid" id="A0A194RQ74"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="504" mass="56158" checksum="637AA63E4356A3D4" modified="2016-10-05" version="1">MDFSSLNPTTSNALNLAARSNDVEKVKRLIKKINPNCVDNRGWTCLHEAAAADSYESLLVILNHPDCRHLAEDHEGCTALQVACSNGASIRTITALLDHAPDIANYGTYENVTPLHIASCQGNLDLVQLLIEYGAMLDVQDFDGHTALHGAVLAKQPEAVKILLCAGADPEIRDESDFTAFHFACYKGCLESVKALLPYVNNINQVSINGDSPLMLAVIGVCDDVVSYLIEVGADIHVKDVDNDMALNIALKSGHSSIFKKLLFATDREKINNDIILYACKPHYLKVDILESLLSYDLGPKFYDLVEPFHVVLEKIGNIRPTYLTSAPLNSYLNICEYIFQMSPKRFEEYFYIFLANGVFNILCCHGCNVDYCTTKLPSSKELCIPDAFIASLTSNPSTIPVMLPYSLACDPDFLLKFAYQNNILPRIPLQVQEYLLVLIGVDLDKTTAETLSCTVLPLKHLSRIKIRESLRNQLGNKLSSQRYLEVLNTLKVPQIIKDYLRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RQZ9</accession>
    <name>A0A194RQZ9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Glutamate receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_07423</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459833">
        <property type="protein sequence ID" value="KPJ19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RQZ9"/>
    <dbReference type="KEGG" id="pmac:106714162"/>
    <dbReference type="InParanoid" id="A0A194RQZ9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008265389" evidence="21">
        <location>
            <begin position="22"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="410"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="863"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="733"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="907" mass="102983" checksum="85C63D1C0D85EB13" modified="2016-10-05" version="1">MSPISSLLILFITYLCVKVDTLSRFPVGALFNHETKSRSEEVFKVLSSLDTSKPFQGRILHPNVINSLSVSQELCSDTLENRGIVALIDVRPTNGICDITCLLCNKLHVSHLSVAWEIPDTSDQDEFSFFYHPPSELISKAYATLIKELEWDRFTFFYEDDGSFIRLQEVINSWPYNNDRIQFEKLEPEGDNRKTFKNVFGVLRISYHLIDCEVNNIQKYMKEIVSVNNSTQYQSFILTALDSYLIKLDEISQLRANVSTLHLTKSNEPIWRDFGINTAEMPVTIETALTADALNHFEKAIRTMRQENMMEYIDPPEICFAENKAAYKEKAWIHGDALKEVLLQTTFRGTTGNITFDENGKRTNFTLYYSKLDKESQFVHVGTWDSKTDSFLTINSAVTDRSKAITSDSVVRVAMKVGMPYFDVEEANGTIIQKGYAVDLIDAIFKHIRQQKGYGDIKHEIYKTNANSAGNPIVGTKKWDGLIGEVLELNAEMAVSDITITSERSAVVEFSMPFMSLGISMLVRERDPQQPDMFSFIKPLALDVWLYLATAYIIVSFVLLICARMSQGDWVNPHPCNQHPENLQNIWSLYNCMWLTVGAIMTQGCDILPRAAGSRWVTGMWWFFALIVTASYTANMSTFLSNSRRDNEIKDVKELSEQNEVSYGVLINGSTYNFFANSNDSVYQKIWTVMKSAKPTVFTNNNDEGRDRVVRSKGNYVFFMESTAIEYYMQRNCDLKMVGSKLDSKDYGIALHKNSPYKRLVDNAILALQETGDLLAMKKKWWESDVKEGNCEKSTNEAEDNGSLQMKNTSGIFLVLGFGGILGFFVAIINFLLHARQISVKEKVTFKEAVLSEWRASLDPRVLHKPAAPPRSAPPSASPSLRRERSQSRAVSVLRAATSFINFDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RR50</accession>
    <name>A0A194RR50_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">RR48_07240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Ya'a_city_454_Pm</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ459995">
        <property type="protein sequence ID" value="KPJ18516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RR50"/>
    <dbReference type="STRING" id="76193.A0A194RR50"/>
    <dbReference type="InParanoid" id="A0A194RR50"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KPJ18516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="423" mass="48437" checksum="D75CC98CD75986D9" modified="2016-10-05" version="1">MRDLYGRVSTPYLGLWLFWRPALLVNSPDIARRILVKDSAVFRDRFLSSGTKDPIGGRNLFTVNDPTWSEMRRRLTVMFTAARLRHLQTFMTLKSKQLMQRIHNDMEMNGQVDVKLMYTDFSTDVIGTTSFGVDSDATLTGQSALRTVTKEFMKYSALRGIGWACIFFFPEMVDVFGFSLFPKSTVAYFRKVYHKIITQRGGYNGDISENKDLIDLLRKIKQDFEKEDKDIPEDTLIAQAAIFLQGGFDTVSSTLSFCTNELAFLPQLQEKLYKEVCEVKKRYGNKDLDPNALNELTLMQCVMKGYDKLTIPAGTPVYVNGLGLHYDPNIYPEPMQFNPDRFLPENEKKIPPFTYIPFGEGPRMCIGRRFGEQTFLTALSHVIVNYRILPTPNAKLPADIDIEKKGIFVSPGEKIYTMFKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RRL2</accession>
    <name>A0A194RRL2_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459989">
        <property type="protein sequence ID" value="KPJ18686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RRL2"/>
    <dbReference type="InParanoid" id="A0A194RRL2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ18686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="105" mass="11594" checksum="DE9209B408161A0D" modified="2016-10-05" version="1">MKELYAVDSTFADLRVELKRVGLLTFPDLTADATKRRNRGQRCAFVWGPLGAVGAQPGSGRPALPFTVSPCVVCVRRTCERRLSVSPLVSPRITARPHMRCEPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194RSQ6</accession>
    <name>A0A194RSQ6_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_12617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459984">
        <property type="protein sequence ID" value="KPJ19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194RSQ6"/>
    <dbReference type="FunCoup" id="A0A194RSQ6">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A194RSQ6"/>
    <dbReference type="KEGG" id="pmac:106720709"/>
    <dbReference type="InParanoid" id="A0A194RSQ6"/>
    <dbReference type="OrthoDB" id="9939609at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="187" mass="21618" checksum="7460A9A03CB805EF" modified="2016-10-05" version="1">MLRKTLINITRANFQINFVRNAQKRYPKVDKKLQAAAESLAARGFLRPNKPWQPPTNINETIEKICSQYGLKSDSEFESLEVKFNVLKTCFEETGHGVPNSLLHTIENVDNLQEFYETPVEVLTPFDALKKMDLPKNLHIQEDYVRFHPDKDTLFNGQSAFPKSSTIVSGLKTRRKYEGYTAKTYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PB70</accession>
    <name>A0A0N0PB70_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_04966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461133">
        <property type="protein sequence ID" value="KPJ08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PB70"/>
    <dbReference type="STRING" id="76193.A0A0N0PB70"/>
    <dbReference type="InParanoid" id="A0A0N0PB70"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="328" mass="36968" checksum="32938CD61E6E73FD" modified="2015-12-09" version="1">MPPLWQNVHSLAAKEKRYIILHSTKCSYEALQALSFREFKQVGKVVIVTGGNNGIGFETAKDLAERGARVILACRDESRGTAARDKIIAATGNNDVHYRHLDLASLTSVKKFAEEFIRDEKCLDILINNAGMNGSRNVRTEDGLLLGMQTNHFAPFLLTCLLVPLLKSSAPSRIINVSSMAHNRATLNLDNLNMEKETEETFSKNHVYALSKLCNILFTVELSRRLKGSKVTTNSLHPGVVDTDILDEMDFKYVHLIKRLARPLLKNRWEGSQTTIYLAVSPEVENVSGKYFRDCKMVDVSTEQARDVELARKLWEKSEKLLNFKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PBU8</accession>
    <name>A0A0N0PBU8_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prothoracicostatic peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RR48_04227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Ya'a_city_454_Pm</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460889">
        <property type="protein sequence ID" value="KPJ11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PBU8"/>
    <dbReference type="STRING" id="76193.A0A0N0PBU8"/>
    <dbReference type="InParanoid" id="A0A0N0PBU8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KPJ11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="288" mass="33119" checksum="3EFD85523436D77A" modified="2015-12-09" version="1">MDAEGWPPAPFVVMDADLELTDEEKRAWSSLHGGGGWGKRGWQDMSSVWGKRAWQDLNPAWGKRGWQDLNSAWGKRGWQDLNSAWGKRGWQDLNSAWGKRGWQDLNSAWGKRSSNDVNQAPWEKRGWQDMSSAWGKRSWQDMSSAWGKRGWHDMSSAWGKRSPTSKWANFHGSWGKRAMTEPEIEDYEMAVESVVPIRQVEEAADKDAMEHPEKKAWSALHGAWGKRPAKQPYASGSYYWKREPGWTNLRGMWGKRAQWLPDIHVLSMDEHGNTPWRAAACTRTTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PC38</accession>
    <name>A0A0N0PC38_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_02483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460786">
        <property type="protein sequence ID" value="KPJ12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PC38"/>
    <dbReference type="KEGG" id="pmac:106713882"/>
    <dbReference type="InParanoid" id="A0A0N0PC38"/>
    <dbReference type="OMA" id="CIIMRNK"/>
    <dbReference type="OrthoDB" id="686784at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="248" mass="27593" checksum="802962CACC0F0A7D" modified="2015-12-09" version="1">MDHYLTTYRKDYLWPDLPKAPGAEQHGGIAEIPKLSGEEMAFYQACMQQTRPPDCRCPQYSGGEMPQLPPGKEGGWSRIEIMGPLLDPKLYPARVAAAPETPTSRYNQPNAFLDKLQSKYPMLYSILQNEASPELKQRIDRDRNKTTYHVDYCESGPGAKFDNLQRAADESGSGPCSQPMRLPGDPCRVAPKIRMTTPKTISKQAGGGPDPRAKCETTSLVPPLGKTEYQDNVSKLGGIIMRDKLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCG6</accession>
    <name>A0A0N0PCG6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ataxin-7-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_05403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460651">
        <property type="protein sequence ID" value="KPJ13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCG6"/>
    <dbReference type="STRING" id="76193.A0A0N0PCG6"/>
    <dbReference type="KEGG" id="pmac:106712977"/>
    <dbReference type="InParanoid" id="A0A0N0PCG6"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052237">
        <property type="entry name" value="Ataxin-7-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117">
        <property type="entry name" value="ATAXIN 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117:SF24">
        <property type="entry name" value="SCA7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="350"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="682" mass="73792" checksum="5953CDFB9E7C8566" modified="2015-12-09" version="1">MSGEFPFTAKIVSPVKCNEKPWDLWVSEIGHLSPRRDDDSGVFTTPAAVEPKGGASVRRVHESHPYKATERGQARYRRAGVNRLKYQSMSLHGLFPQMDNLNAAVCHMCGVVVKCSAAYRHLLDYHTDCEPILPPPPPAPTVKLKSTPSRSRHKKDIHPPLVPPDFLPKMETSPAHNATAPLSRIVLPQPEMQYLDEPSTSTGVTGEVQVSMESGGLPVVSIQDPDELPLGENITDDILAIMNSEGIQSADDITNAADWKDIIRDIGSMQDMNFQSTDSQQSQDLYTSVDDNSLYTLADTDLSSLQFASNTPPILSTVIDNNLINAQALKVAVPSTPTTKSQSRTKTSKSKFVPREYDPNKHCGVVTAENPKPCTRSLTCKAHALSLRRTVEGRSKPFDTLLAEHRASKDPNSAAAAATPIKHHVPVHSTPTQFNNPPPLDLNDLNGLAADLQVNDIYASLLSVEDPNALLPDTSNITSLLSQPLPPGAFLLPEDAELATDVPILSIATPVEPEVRPEGPPPLVPSDVCWYSSCPRPLALCTFNASHAGSAITLGKKFATVRSNIKSSLSRTSKSSGVSNNYYYQNSLSLSKTMHLNNTNKANKPEVRKLIVTCSATSGGKDVQQTFSDMFGGGEVRHTLNGHVGHAERRPRPGALKAGKRPAPAVLDLGFALDPLLADEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCJ8</accession>
    <name>A0A0N0PCJ8_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_05214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460650">
        <property type="protein sequence ID" value="KPJ13105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCJ8"/>
    <dbReference type="InParanoid" id="A0A0N0PCJ8"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ13105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="272" mass="31222" checksum="3ED6D9D8934846BA" modified="2015-12-09" version="1">MITIFSSNKQYFMHRKYTYCYRSKARGGFRWRCTNTSDCKAYVILSADGSSFTAYGIHSHNPPNYHILPNGTLVQEITMTSGKRYKYIYGYTYGAPVPVKGGLKYRCTRGCELKLIEMDNGRVYYLYDGYTYTYGYKSRKGGTFLWTKRGVKHPLLLLDGFTYSYQKQNANGRVSWYCSRRLKGCRASAISIGDKAYAYKPHDHPPPKRQDSTADIKPLQSSYLFFGIGRRQQQHQLHELAGSPGEIPRPHRRQASSESNSAFRLRSVVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PCW9</accession>
    <name>A0A0N0PCW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RR48_04491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Ya'a_city_454_Pm</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460448">
        <property type="protein sequence ID" value="KPJ14665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PCW9"/>
    <dbReference type="STRING" id="76193.A0A0N0PCW9"/>
    <dbReference type="InParanoid" id="A0A0N0PCW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KPJ14665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="150" mass="16511" checksum="CDEB0B9BBB95698A" modified="2015-12-09" version="1">MSIKYNGHHIVGSPFKVEAIGENLAEIGAQETSSVTVETVQKVSKSAQKLGPVLPHFKSDASKVTSKGMGLKKAYLNKHNQFTVHAGDAGNNILYVGIYGPKGPCDEVQLKHKGKNNYECWYVVRDRGEYIVIVKWGDEHIPGSPYKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PDL6</accession>
    <name>A0A0N0PDL6_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine protease snake</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_01864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460130">
        <property type="protein sequence ID" value="KPJ17530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PDL6"/>
    <dbReference type="FunCoup" id="A0A0N0PDL6">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N0PDL6"/>
    <dbReference type="InParanoid" id="A0A0N0PDL6"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="101"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ17530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="343" mass="38032" checksum="8C8A2E529749B3CC" modified="2015-12-09" version="1">MSQTRVAERRRRESTDGRVRSFYPNVRPNWLVCPAIRTTPQVNQNGCPPVSPELTSRKTGRKAWDKCIDYQEQLVYPCVKGSGYSGMVRARRCHHNTDALIVGGSDAAKREFPHMVLLGFGSSPSEATWDCGGTLISEWYILTAGHCTSSNRILVSYARLGVLDKRQLDNSQLYKIQNIIKHPEYKSPSKYNDIALLKTAIEMKLSHEAVPACLPVDTVSDEKAVATGWGATRNKGDNSDLLEKVTLTKFSERECSSSHRPQRKLERGFDANTQICYGDKYQSKDTCQGDSGGPLQVKNPHINCMYTVIGVTSFGSGCGTVGLPGVYTKVTAYVSWIEGIVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFF7</accession>
    <name>A0A0N0PFF7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_00543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01028355">
        <property type="protein sequence ID" value="KPJ21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFF7"/>
    <dbReference type="STRING" id="76193.A0A0N0PFF7"/>
    <dbReference type="InParanoid" id="A0A0N0PFF7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="97" mass="10891" checksum="D54FC42136D87EEF" modified="2015-12-09" version="1">MSTRRLSEDNTREVSPAAGKVNRNWWRGRGRGRGRRGRRGRGRASQSVSRPAQDNETPTSDSETPMAARKSVERKLVTPDKSPVKQNDASPSKYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFK3</accession>
    <name>A0A0N0PFK3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein capicua-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LADJ01039080">
        <property type="protein sequence ID" value="KPJ21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFK3"/>
    <dbReference type="STRING" id="76193.A0A0N0PFK3"/>
    <dbReference type="InParanoid" id="A0A0N0PFK3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="62" mass="7766" checksum="C4C3A2127107A800" modified="2015-12-09" version="1" fragment="single">KERRIRRPMNAFMIFSKRHRQMVHQRHPNQDNRTVSKILGEWWYSLKPEEKQKYNELASEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N0PFV2</accession>
    <name>A0A0N0PFV2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_00868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="LADJ01066115">
        <property type="protein sequence ID" value="KPJ21681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N0PFV2"/>
    <dbReference type="InParanoid" id="A0A0N0PFV2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="49"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ21681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="232" mass="26104" checksum="BC3C6B83E20B7DEA" modified="2015-12-09" version="1">MYIISSIKNMESMSALEREAQDHQHDVAKIIASGASDVERFYAGSNIFLTGGTGFIGKHIIEKLFRCCNVNKVYLLLRSKKGKTVQQRIDQILKDPVFESLQKYKPDFVTNIIPIEGDISEKELGIGADDRNIITEQVNVIIHAAANVNFNENVKAATLINVRGIREIVRLAKCCKQLRSIVHVSTAYSHASKSRVRQAVKEQFYDSPVPPNAIIEMAETIEKNKLENMMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I5A4</accession>
    <name>A0A0N1I5A4_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_03418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461072">
        <property type="protein sequence ID" value="KPJ09814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I5A4"/>
    <dbReference type="FunCoup" id="A0A0N1I5A4">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1I5A4"/>
    <dbReference type="InParanoid" id="A0A0N1I5A4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin C-terminal" evidence="11">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ09814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="191" mass="21364" checksum="B0F8BF58C9B642DD" modified="2015-12-09" version="1">MKLLPRPSAAHNRRSLPDVHTSRLETLSDLQLSARVSGPPSTLGRKTIRRSRSADASRMLSVSKTQNRSRSVYRTPMYNKNPMNYPAITPKVAPHTSLTVLRQPRQGEMVVSMSGSPVLVPSVYSMQKDEKASCNIMLNDGTMLSLQPRQLRQSQAFIPFSLMDSQVLSQLKTLKDNLVKMVELGEKTIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1I826</accession>
    <name>A0A0N1I826_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RR48_04481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Ya'a_city_454_Pm</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="KQ460466">
        <property type="protein sequence ID" value="KPJ14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1I826"/>
    <dbReference type="STRING" id="76193.A0A0N1I826"/>
    <dbReference type="KEGG" id="pmac:106711293"/>
    <dbReference type="InParanoid" id="A0A0N1I826"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KPJ14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="273" mass="30160" checksum="BF6CE0E1BBFC0F88" modified="2015-12-09" version="1">MASKVAVVTGGNKGIGFAIVRGLCKRFEGDVYLTSRDEERGKKAVSELNKEGLSPLYHQLDITVKESVEVFRDYIKQKYGGIDVLVNNAAIAFKVNAKESVAVQAAETLRVNYFSVLTTCEVLFPILRNGARVVNVSSSAGHLSHIKSESLRNRLKDPKLTIPELSELMNQYIDDAKQGIHSDKWGNSSYVVSKVGLTALTKIQQRELNDRDIKVNAVHPGYVDTDMTSHKGRLSIDEGAVAPLFLALDAPDSVRGQYVWCDKRIVDWDGPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IB30</accession>
    <name>A0A0N1IB30_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pupal cuticle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RR48_02793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Ya'a_city_454_Pm</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460208">
        <property type="protein sequence ID" value="KPJ16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IB30"/>
    <dbReference type="STRING" id="76193.A0A0N1IB30"/>
    <dbReference type="InParanoid" id="A0A0N1IB30"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012610481" evidence="2">
        <location>
            <begin position="16"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KPJ16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="233" mass="24294" checksum="A11AA782AEE6D6DD" modified="2015-12-09" version="1" fragment="single">QIVVACLALACGAHASGWAGPPANIALSQDGRNILDTPEVAQARAAHIAALQQASQNNPNPQDDGSYDPRWDNEEYWQGQQQQRSWNGAPAASWNSAPASSWNGAPANQWNAAPATPSWNSGAPAPVAETPEVAQARAAHLAALSAAKPAGQQWNAAANNQWNAPANNQWDAPAHNQWNGAPSWQGPPAQIRLAQNGNGILETPEVAAARAAHLAAHAQAGHGGSAHAPQQHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IDI0</accession>
    <name>A0A0N1IDI0_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zyxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_03752</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ461153">
        <property type="protein sequence ID" value="KPJ08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IDI0"/>
    <dbReference type="FunCoup" id="A0A0N1IDI0">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IDI0"/>
    <dbReference type="KEGG" id="pmac:106717681"/>
    <dbReference type="InParanoid" id="A0A0N1IDI0"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09357">
        <property type="entry name" value="LIM3_Zyxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000027">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000057">
        <property type="entry name" value="Zyxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF2">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="342"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="46313" checksum="4B5B51ACAFAEF8B3" modified="2015-12-09" version="1">MNTLDKQLADLRIYANELDAKLQDDINSAKIKPSIPPKKSKAPQPQIPQSYTVKSACEPSYSSRLEYGSRTSSTYSNLVPVKSCIVRNSSRLRSGDVLLYSNLLPPGGTNHVYSNIPMQRASESIYGDRDARSEMSRISDLGAQSNYSELRRPGSAYPPSSASVNAQDFSTYGGSQTSSTYESLYEPINPRPCSQLSGTSLYGGYVGTAEPTPEPDDALYCGNCYRCGEKIMGETTGCTAMERIYHIKCFCCQQCGINLQGRPFYAVQGKALCERDYLDTLEKCCVCGDPILDRILRATGKPYHPRCFTCVVCQKSLDGIPFTVDAVNRIHCIEDFHKRYAPRCARCREPIVPEGGAEETVRIVALDKSFHFACYACEDCGASLCSREEGRGCYPLDGHLYCKQCNARRIQDLSRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IED3</accession>
    <name>A0A0N1IED3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtubule-actin cross-linking factor 1, isoform 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460547">
        <property type="protein sequence ID" value="KPJ14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A0N1IED3">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IED3"/>
    <dbReference type="InParanoid" id="A0A0N1IED3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="36"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="4266"/>
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            <begin position="4716"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IFT7</accession>
    <name>A0A0N1IFT7_PAPMA</name>
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        <submittedName>
            <fullName evidence="8">Transmembrane protein 135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_01160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KPJ17226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="203"/>
        </location>
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            <end position="330"/>
        </location>
    </feature>
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        <location>
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            <end position="353"/>
        </location>
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    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KPJ17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="418" mass="47540" checksum="272446C6ECFD00AC" modified="2015-12-09" version="1">MKSNDRKRTGHLVINCRLHRLGVKCFTMVEVSKHLFDEKCRDVSCQLLLHPWHSSCLMSTLPAYKHSFLGSAKFYLIVHLVQNVLRGRKVLKKKELIQMGEYYMRSTILGGLISGSCVTFGCLFRWLLGKKMNYYTYMFLPNVINGVCILLEPPSRRGLIINLFSNLTIEFMLRSWERSGHLSLTTTKKTLMFMVGSAVLFYLMRLEGDKATRTPLLWLFTPEKVKRKTDNSNTICPHEDDCWKYMLKGTATYFGIGAAVSLAQVILPKITSPLKALSSIRGSHLKLALFFGSYIGIYRSVICYLCRKRKVDSALYALPAGYLAGLSFIFKPSLGFAIASLTGAFKLYSTILYEKKMLPENIPLTVILYCLCQGTLFHARFMHPDVCPSYVFKLMKSVSNGTSEQIYSNFLEILKSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IGT1</accession>
    <name>A0A0N1IGT1_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 41 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RR48_05954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Ya'a_city_454_Pm</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ459890">
        <property type="protein sequence ID" value="KPJ19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A0N1IGT1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF26">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="364"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KPJ19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="525" mass="57472" checksum="63498BE66CC3F8C8" modified="2015-12-09" version="1">MASINSNGDLKSPGDPEKKVPETDAEKQPLSGKKEERWWTTLMQVAVPFFIAGCGTIGAGLVLGSVRNWEVFQNVSAIFVLVPSLSGLKGNLDMCLASRLSTQANLGNMETPREVISMVVGNISLVQVQAIVAATVVSMFAIVVNSITDRAFNGSFVLLLIASAVFTATTTCFVLDFVMVLVIFGSQKFKVNPDNVATPLAASIGDIVSNSVLAVTAQYMYDQIKISLWQPIALMCVYYSLLPLWVFIVWRNKYTKKVLMTGWTPVISALFISGIGGIVLDQAVEKYQGYEVFQPIVNGIGGNLVCVQSSRLTTHLHQTAILGILPEETRIVEWPWKTLFFGSDIGGIVLDQAVEKYQGYEVFQPIVNGIGGNLVCVQSSRLTTHLHQTAILGILPEETRIVEWPWKTLFFGTAAAKVARMLLVLALCGQVVFMIVADFIYQGLVSIQFAFGLTYLLCSMLQVMMLLYLAYMLIHFMWKKKKDPDNAAIPYLTALGDLLGSVFLGLAFVILSIFGLQYGNNVPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IJI1</accession>
    <name>A0A0N1IJI1_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RR48_00216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Ya'a_city_454_Pm</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LADJ01017996">
        <property type="protein sequence ID" value="KPJ21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IJI1"/>
    <dbReference type="InParanoid" id="A0A0N1IJI1"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KPJ21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="234" mass="25583" checksum="60243DD9C108FF84" modified="2015-12-09" version="1" fragment="single">APLPPPTWTVPFEAINKNIICLQMKNQLMAYPNLTESEDCLIANIYVPDTKTNKLPVLVYVHGGAYQIGHGEFAVAKNLIREKKMIIVNFNYRLGPHGFLCLGTPDVPGNAGMKDQVALLRWVKKNIASFGGNSDDITIMGSSAGSSAVDLLMLSPMTKGLFSKVIPESGSNMAVFSAQGNPVENAKAYAKLINFTGNEDDVYALEEFYKTVPEEVLHSFDVLGQKDSTFFFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1INW9</accession>
    <name>A0A0N1INW9_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterogeneous nuclear ribonucleoprotein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_04352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460772">
        <property type="protein sequence ID" value="KPJ12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1INW9"/>
    <dbReference type="STRING" id="76193.A0A0N1INW9"/>
    <dbReference type="InParanoid" id="A0A0N1INW9"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="277" mass="30056" checksum="DD0BE5AF9F4BE744" modified="2015-12-09" version="1">MCDAGAPESRAPLLTPVRSPTAASRSAHASRAGHLPTCQPAHWCSSIHYALLTYSHHHVRERPLNHSNRTKCVDLIGISLVLAGGDMKRDAYSEDGPVHKRQRQTDDEVTFLIPSKVAGSIIGKGGSNISKLRNEYKASITVPDCPGPERVLSISASDIDTILEIVKDILPNLADGGLKGGNEDLDIRLLIHQSRAGCVIGKAGAKIKELRESCVLPTPRVSGAVKHSCERRVRQLRPRGGRQVREQPPEGRTKTRAPGPYPLAQCSAMRAPLYNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPB4</accession>
    <name>A0A0N1IPB4_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RR48_04402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Ya'a_city_454_Pm</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460636">
        <property type="protein sequence ID" value="KPJ13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPB4"/>
    <dbReference type="STRING" id="76193.A0A0N1IPB4"/>
    <dbReference type="InParanoid" id="A0A0N1IPB4"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF46">
        <property type="entry name" value="ZINC FINGER PROTEIN GFI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KPJ13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="387" mass="45401" checksum="EB86860AA47C0F21" modified="2015-12-09" version="1">MLSNCERNNTIDAISCRACLETNNEGFVSLENKSELSQLFEFCVGLSVEPDDMYQILCQPCTTIVKKFADFKVQCHTSHEILKSIANNRNNICMEKSSTIEEVDIDNKCDLNTLNLIQDENSSDNKESNHHFNTKDMEKSRSNEKENPSLCRFSTSCREDLVVHLSEHWNNNDLRCKLCSYVGRDLAELFGHRFLFRSMIETHMAEHANVRDNVCHICGKAFKRASYLKVHFNTVHIKEPVKCTHCNKTFKSPASLKDHLNYVNKEKKFQCDVCFKYFVSELSLKKHKFWHTEMRPFSCKDCGIKYKAKSYLKIHMRKHTGQRPYTCDQCDKCFPTTMQLKRHRMVHTGERPHKCKNCNQSFYYKKQLLRHIGLKHKDEEKPEINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPF3</accession>
    <name>A0A0N1IPF3_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fat-like cadherin-related tumor suppressor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RR48_02686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Ya'a_city_454_Pm</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ460545">
        <property type="protein sequence ID" value="KPJ14085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPF3"/>
    <dbReference type="STRING" id="76193.A0A0N1IPF3"/>
    <dbReference type="InParanoid" id="A0A0N1IPF3"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF118">
        <property type="entry name" value="DE-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="97"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="222"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KPJ14085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="363" mass="38785" checksum="4FFEC4AF316F0B0E" modified="2015-12-09" version="1">MGEPRLPPAGADSTATVTVEVTNENDCPPQFSQAAYEAEVLLPTAAGVRVLVLEAQDADGPPAGALVFDILEGDPEGASEAEVSVRAWGGGATPRWPRAHYELEAREDAAPGRALTPTLQAEPPLGRALIYTLHEGPAELFEVHFETDRSAEQIRSAVHKQNRVVLCAVFAGAVVPRAALDYEAAREHRLGVRATDTVSGAFADVTVLVRVLDVNDCAPRFERDEYRVSVREAAPVGASLLTVQAADDDQGDNGNVTYSLSAWGSGAATVGAVGALPFAVGAHSGEVTVAGALDREQCAEHHLLLTAADAGQPALHTTAHLFITIRSFKKEEHEEIELYLLEFARNLFWLQFNKKIIDKIQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPW7</accession>
    <name>A0A0N1IPW7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription elongation regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_02561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ459988">
        <property type="protein sequence ID" value="KPJ18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPW7"/>
    <dbReference type="STRING" id="76193.A0A0N1IPW7"/>
    <dbReference type="InParanoid" id="A0A0N1IPW7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF5">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005874081" evidence="3">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KPJ18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="175" mass="20194" checksum="B00A5335EB0E9859" modified="2015-12-09" version="1">MSSQTGWSVRLVVHFVFATNAYALQKTRTYYCVHFNALLADLVRNPDLTWREAKKQLKKDHRYKLAELLSKEDKERLFSQHISVLSNKRRDKLRALLTELGVTSTARWRDVKDQLQQQPAPPVYASASQVEKNRYTALDHAPGERLQTIMAHLEELHKKGPPPPPTASEPTRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPY7</accession>
    <name>A0A0N1IPY7_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RR48_03522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Ya'a_city_454_Pm</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ460129">
        <property type="protein sequence ID" value="KPJ17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPY7"/>
    <dbReference type="InParanoid" id="A0A0N1IPY7"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KPJ17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="268" mass="29620" checksum="C1ED6C13E447CB85" modified="2015-12-09" version="1">MERKLTREDFMRKSFRAPRAAQSPETQGNGPQPPLVSLAMLERTPQPSRAQYEVTASGIAPKRLEINRTHPIHLKSFQTPDPPDENGPTPPSDDVLRKLERQIGEMERGLERAQNGNVSVDERVRYAEHENLLRTGVSSVGGGGYLPTDSDTEHDTVPFNRNETTRSSTGATAPATRPATRLARTHSDTQQHNVAATARLMRKLADGGTKDEKSKVISRKAIQARMERVKNSVVGTKHEHRVLAEHKAEPPARTPTSPVSPRSSVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IPZ2</accession>
    <name>A0A0N1IPZ2_PAPMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">RR48_01082</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Ya'a_city_454_Pm</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="EMBL" id="KQ460120">
        <property type="protein sequence ID" value="KPJ17681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IPZ2"/>
    <dbReference type="FunCoup" id="A0A0N1IPZ2">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="76193.A0A0N1IPZ2"/>
    <dbReference type="InParanoid" id="A0A0N1IPZ2"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KPJ17681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053240"/>
        </source>
    </evidence>
    <sequence length="221" mass="24416" checksum="97CD916400A76B1A" modified="2015-12-09" version="1">MAAKWEPKNKNILITGAASGLGAAYAEALLKEGAKNIAVLDIDVKTGENFVSKLNETYNNKAIFIKCDVSKEEDIKNSFNIVLNKFKRIDLLINNAGIMSDTDSMWRLACDVNWQGLVSFTMKAVKHMRKDEGGDGGTIVNISSTAGICKLNFLPIYCGSKGAVLHFSQSLAVCIPLMYNLLHTRSALGKCRYQKKATIDKLLCFLPTSKRRRVSIRMCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0N1IQ25</accession>
    <name>A0A0N1IQ25_PAPMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein diaphanous</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RR48_05599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Papilio machaon</name>
        <name type="common">Old World swallowtail butterfly</name>
        <dbReference type="NCBI Taxonomy" id="76193"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Papilionoidea</taxon>
            <taxon>Papilionidae</taxon>
            <taxon>Papilioninae</taxon>
            <taxon>Papilio</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="8212" last="8212">
            <title>Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.</title>
            <authorList>
                <person name="Li X."/>
                <person name="Fan D."/>
                <person name="Zhang W."/>
                <person name="Liu G."/>
                <person name="Zhang L."/>
                <person name="Zhao L."/>
                <person name="Fang X."/>
                <person name="Chen L."/>
                <person name="Dong Y."/>
                <person name="Chen Y."/>
                <person name="Ding Y."/>
                <person name="Zhao R."/>
                <person name="Feng M."/>
                <person name="Zhu Y."/>
                <person name="Feng Y."/>
                <person name="Jiang X."/>
                <person name="Zhu D."/>
                <person name="Xiang H."/>
                <person name="Feng X."/>
                <person name="Li S."/>
                <person name="Wang J."/>
                <person name="Zhang G."/>
                <person name="Kronforst M.R."/>
                <person name="Wang W."/>
            </authorList>
            <dbReference type="PubMed" id="26354079"/>
            <dbReference type="DOI" id="10.1038/ncomms9212"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Ya'a_city_454_Pm</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. Diaphanous subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ460036">
        <property type="protein sequence ID" value="KPJ18420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0N1IQ25"/>
    <dbReference type="STRING" id="76193.A0A0N1IQ25"/>
    <dbReference type="InParanoid" id="A0A0N1IQ25"/>
    <dbReference type="Proteomes" id="UP000053240">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.40">
        <property type="entry name" value="Formin, diaphanous GTPase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044933">
        <property type="entry name" value="DIA_GBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Dia
[file cut: first 33554432 bytes kept]
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